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for="searchright"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"> <title>Search icon</title> <use xlink:href="#icon-search"></use> </svg> </label> </form> </div>       </div> </div> </header> <div class="hero"> <div class="hero__top" style="background-image: url('https://admescope.com/wp-content/uploads/sites/2/2023/05/080-Admescope-lab.jpg');"> <div class="hero__content"> <div class="hero__heading"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"><use xlink:href="#icon-services-invivodmpk"></use></svg> <h1>In vivo DMPK</h1> </div> </div> </div> </div> <main class="wp-block-group main main--page is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group main__content is-layout-constrained wp-block-group-is-layout-constrained"> <div id="ez-toc-container" class="ez-toc-v2_0_69_1 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction"> <div class="ez-toc-title-container"> <p class="ez-toc-title" style="cursor:inherit">Table of Contents</p> <span class="ez-toc-title-toggle"></span></div> <nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-1" href="#Our_services_for_in_vivo_DMPK_research" title="Our services for in vivo DMPK research">Our services for in vivo DMPK research</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-2" href="#Animal_Pharmacokinetics" title="Animal Pharmacokinetics">Animal Pharmacokinetics</a></li></ul></nav></div> <div class="entry-content wp-block-post-content is-layout-flow wp-block-post-content-is-layout-flow"> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Our_services_for_in_vivo_DMPK_research"></span>Our services for <em>in vivo</em> DMPK research<span class="ez-toc-section-end"></span></h2> <figure class="wp-block-image alignright size-full"><img fetchpriority="high" decoding="async" width="336" height="386" src="https://www.admescope.com/wp-content/uploads/sites/2/2023/06/in-vivo-dmpk-1.png" alt="Admescope lab team members working with in vivo DMPK research services" class="wp-image-1495" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/06/in-vivo-dmpk-1.png 336w, https://admescope.com/wp-content/uploads/sites/2/2023/06/in-vivo-dmpk-1-261x300.png 261w" sizes="(max-width: 336px) 100vw, 336px" /></figure> <p class="has-medium-font-size">Our <em>in vivo</em> drug metabolism and pharmacokinetic (DMPK) services cover a complete range of different animal studies in several species. The <em>in vivo</em> DMPK services are available for all drug modalities, e.g., small molecules, peptides, oligonucleotides, antibodies and ADCs.</p> <p class="has-medium-font-size">We have AAALAC-accredited in-house animal facilities housing mice and rats, and studies with other species are performed together with chosen European in-life partners. The partner for each study is chosen based on the study requirements (animal species, sample type, radiolabeled vs non-labeled compound). We manage the whole process for you; from study planning to bioanalytical tasks (LC/MS/MS, LC/HR-MS, LC/radiodetection), pharmacokinetic evaluation and reporting.</p> <p class="has-medium-font-size">Samples for bioanalytics and pharmacokinetic evaluation from animal work performed by the customer or other in-life-site are also accepted. These studies often include identification of circulating or excreted metabolites, analyzing known biomarkers, as well as evaluation of metabolites’ pharmacokinetics with respect to the parent drug or multispecies metabolite profiling.</p> <p class="has-medium-font-size">From a drug safety perspective, we offer correlation of metabolite exposure between human and preclinical species and thus identification of metabolites disproportionate or unique in human. This can be done by comparing the <em>in vivo</em> metabolite profiles from animal species to <em>in vitro</em> human models and characterizing <em>in vivo</em> human metabolites from FIM, SAD, MAD or human ADME studies with cold or radiolabeled compounds against the preclinical animal samples. More detailed description of this service can be found on our <a data-type="URL" data-id="https://www.admescope.com/services/safety-metabolism/" href="https://www.admescope.com/services/safety-metabolism/">Safety Metabolism</a> page.</p> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-text-color has-symeres-font-color has-alpha-channel-opacity has-symeres-font-background-color has-background is-style-wide" /> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Animal_Pharmacokinetics"></span>Animal Pharmacokinetics<span class="ez-toc-section-end"></span></h2> <ul class="wp-block-list"> <li class="has-medium-font-size"><strong>In-house AAALAC accredited animal facilities to house mice and rats</strong></li> <li class="has-medium-font-size"><strong>Studies with other species are conducted with AAALAC accredited/GLP partner companies</strong></li> <li class="has-medium-font-size"><strong>Single or repeated dosing (i.p., i.v., p.o., s.c., i.m.)</strong></li> <li class="has-medium-font-size"><strong>Single compound or cassette dosing</strong></li> <li class="has-medium-font-size"><strong>Studies with small molecules, peptides and proteins</strong></li> <li class="has-medium-font-size"><strong>Plasma sampling, tissue and CSF collection</strong></li> <li class="has-medium-font-size"><strong>Metabolic cages</strong></li> <li class="has-medium-font-size"><strong>Metabolite identification and profiling</strong></li> <li class="has-medium-font-size"><strong>Bioanalysis by LC/MS/MS or UPLC/High-resolution-MS analysis</strong></li> <li class="has-medium-font-size"><strong>On-line and off-line radiodetection</strong></li> <li class="has-medium-font-size"><strong>Full pharmacokinetic evaluation using Phoenix® WinNonlin®</strong></li> </ul> <figure class="wp-block-image alignleft size-full"><img decoding="async" width="336" height="386" src="https://www.admescope.com/wp-content/uploads/sites/2/2023/06/in-vivo-dmpk-2.png" alt="Animal Pharmacokinetics services from Admescope - a preclinical contract research organization (CRO)" class="wp-image-1496" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/06/in-vivo-dmpk-2.png 336w, https://admescope.com/wp-content/uploads/sites/2/2023/06/in-vivo-dmpk-2-261x300.png 261w" sizes="(max-width: 336px) 100vw, 336px" /></figure> <p class="has-medium-font-size">In <em>in vivo</em> DMPK studies, compounds are administered to rodents and samples collected over a pre-defined time period. The dosing regimen and sampling are designed according to the project needs and prior information available on the study compounds, and the concentration-time data can be summarized using non-compartmental analysis (NCA) or compartmental modelling. Several options are available for bioanalytics, and the methods are always optimized for the study compounds instead of using generic methods. Furthermore, when LC/HR-MS is used, the same data can be used later for metabolite identification and profiling.</p> <p class="has-medium-font-size">The experiments can be designed e.g., for initial PK screening of multiple compounds, <em>in vivo</em> BBB permeability or for more advanced PK profiling. Metabolic cages are available for investigating the excretion of the compound to urine and feces. Also radiolabeled compounds can be used. 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src="//js-eu1.hs-scripts.com/25214463.js"></script>  </div></div> <section class="downloads__aside" id="sidebar-downloads"> <button class="downloads__label"> <span>0</span> <svg><use xlink:href="#icon-download"></use></svg> </button> <div class="downloads__content"> <button class="downloads__close" id="downloads-close"><svg xmlns:xlink="http://www.w3.org/1999/xlink"><title>Close this panel</title><use xlink:href="#icon-times"></use></svg></button> <div id="selected-files" class="downloads__files"> <h3>Files</h3> <div> <ul></ul> </div> <button style="margin-top:20px;" id="remove-all-files" type="submit" class="button">Remove all</button> </div> <form class="downloads__form form" action="https://admescope.com/wp-admin/admin-ajax.php" method="POST" id="symeresdownloads"> <p>Please, provide us your email address so that we can send you a link for downloading the requested files.</p> <div class="form__row"> <div class="form__col"> <label for="email">Email</label> <input id="email" name="email" type="email" placeholder="Email" required> </div> </div> <div class="form__row"> <div class="form__col"> <label for="agreement"> <input id="agreement" name="agreement" type="checkbox" required> <div>By downloading, I agree to the <a href='/privacy-policy/'>privacy policy</a></div> </label> </div> </div> <div class="form__row"> <div class="form__col"> <input type="text" name="downloaded_files" value="" style="opacity: 0;height: 0;overflow: hidden;"> <button type="submit" class="button button--primary">Download file(s)</button> <input type="hidden" name="action" value="symeresdownloads"> </div> </div> </form> </div> </section><script> jQuery( document ).ready(function() { jQuery(function ($) { let downloads = {}; $('body').on('click', '#downloads-close', function(){ $('.downloads__label').css('display', 'flex'); $('.downloads__content').css('display', 'none'); }); $('body').on('click', '.downloads__label', function(){ $('.downloads__label').css('display', 'none'); $('.downloads__content').css('display', 'flex'); }); $('body').on('change', 'form.downloads', function(){ let downloadsList = ''; let filenames = {}; $('input:checkbox[name=download]').each(function(){ filenames[$(this).data('filename')] = $(this).data('filetitle'); if (this.checked) { downloads[$(this).data('download')] = $(this).data('filename'); } else { if ($(this).data('download') in downloads) { delete downloads[$(this).data('download')]; } if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsFromLocalStorage) { delete downloadsFromLocalStorage[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsFromLocalStorage)); } } } $('input[name="downloaded_files"]').val(Object.values(filenames).join(',')); }); // set filenames + titles in localStorage if (Object.keys(filenames).length) { let filenamesJson = JSON.stringify(filenames); if (localStorage.getItem('filenames')) { let currentFilenames = JSON.parse(localStorage.getItem('filenames')); filenames = { ...currentFilenames, ...filenames }; filenamesJson = JSON.stringify(filenames); } localStorage.setItem('filenames', filenamesJson); } if (Object.keys(downloads).length) { $('.downloads__aside').css('display', 'block'); let downloadsJson = JSON.stringify(downloads); if (localStorage.getItem('downloads')) { let currentDownloads = JSON.parse(localStorage.getItem('downloads')); downloads = { ...currentDownloads, ...downloads }; downloadsJson = JSON.stringify(downloads); } localStorage.setItem('downloads', downloadsJson); } else { if (!localStorage.getItem('downloads')) { localStorage.removeItem('downloads'); } } Object.keys(downloads).forEach(key => { let label = $('.downloads li label[for="download-file-' + downloads[key] + '"]').text(); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloads).length); $('#selected-files ul').html(downloadsList); // if (Object.keys(downloads).length) { //if (localStorage.getItem('downloads')) { // $('.downloads__aside').css('display', 'block'); // } else { // $('.downloads__aside').css('display', 'none'); // } }); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); let downloadsList = ''; $("input[name='downloaded_files']").val(Object.values(downloadsFromLocalStorage).join(',')); Object.keys(downloadsFromLocalStorage).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsFromLocalStorage[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsFromLocalStorage).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } else { $('.downloads__aside').css('display', 'none'); } $('body').on('click', '#remove-all-files', function(){ localStorage.removeItem('downloads'); $('#selected-files div ul li').remove(); $('.downloads__aside').css('display', 'none'); location.reload(); }); $('body').on('click', '#selected-files button', function(){ $('form.downloads input[data-download=' + $(this).data('download') + ']').prop('checked', false).trigger('change'); if (localStorage.getItem('downloads')) { let downloadsLocalObj = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsLocalObj) { delete downloadsLocalObj[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsLocalObj)); //reload sidebar html let downloadsList = ''; Object.keys(downloadsLocalObj).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsLocalObj[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsLocalObj[key] in filenames) { label = filenames[downloadsLocalObj[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsLocalObj[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsLocalObj).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } } }); $('#symeresdownloads').on('submit', function (e) { e.preventDefault(); if (localStorage.getItem('downloads')) { downloads = JSON.parse(localStorage.getItem('downloads')); $("input[name='downloaded_files']").val(''); $("input[name='downloaded_files']").val(Object.values(downloads).join(',')); } var symeresdownloads = $('#symeresdownloads'); var email = $("#symeresdownloads :input[name='email']").val(); var firstName = $("#symeresdownloads :input[name='first-name']").val(); var lastName = $("#symeresdownloads :input[name='last-name']").val(); var company = $("#symeresdownloads :input[name='company']").val(); var action = $("#symeresdownloads :input[name='action']").val(); downloads['email'] = email; downloads['first-name'] = firstName; downloads['last-name'] = lastName; downloads['company'] = company; downloads['action'] = action; runAjaxCall(symeresdownloads, downloads); // Clean up the downloads object delete downloads['email']; delete downloads['first-name']; delete downloads['last-name']; delete downloads['company']; delete downloads['action']; e.preventDefault(); }); function runAjaxCall(symeresdownloads, downloads) { var array = Object.keys(downloads).map((key) => [String(key), downloads[key]]); $.ajax({ url: symeresdownloads.attr('action'), data: downloads, // form data type: symeresdownloads.attr('method'), // POST beforeSend: function (xhr) { jQuery('#symeresdownloads button').hide(); jQuery('<p class="download-status">Your file(s) are being processed.</p>').insertAfter('#symeresdownloads button'); }, success: function (data) { let error = false; if (data.includes('address') || data.includes('download')) { if (!data.includes('Thank you')) { error = true; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } } if (data.includes('Thank you')) { error = false; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } setTimeout(function(){ jQuery('.status-msg').remove(); if (error) { jQuery('input#email').css('border-color', '#d63637'); location.reload(); } if (!error) { localStorage.removeItem('downloads'); $('.downloads__aside').css('display', 'none'); location.reload(); } }, 5000); } }); } if ($('.downloads__label span').text() == '0') { $('.downloads__aside').css('display', 'none'); } $('body').on('change', '.downloads__label span', function(){ if ($('.downloads__label span').text() == '0') { $('.downloads__aside').css('display', 'none'); } }); }); }); </script><script id="wp-block-template-skip-link-js-after"> ( function() { var skipLinkTarget = document.querySelector( 'main' ), sibling, skipLinkTargetID, skipLink; // Early exit if a skip-link target can't be located. if ( ! skipLinkTarget ) { return; } /* * Get the site wrapper. * The skip-link will be injected in the beginning of it. */ sibling = document.querySelector( '.wp-site-blocks' ); // Early exit if the root element was not found. if ( ! sibling ) { 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