Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications

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Versatile Tools for Biotechnological Applications</title> <meta name="description" content="Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications"> <meta name="keywords" content="bacterial gene expression, biotechnology, caged compounds, carbohydrates, optogenetics, photo-removable protecting group"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img 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publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Claus%20Bier">Claus Bier</a>, <a href="https://publications.waset.org/abstracts/search?q=Dennis%20Binder"> Dennis Binder</a>, <a href="https://publications.waset.org/abstracts/search?q=Alexander%20Gruenberger"> Alexander Gruenberger</a>, <a href="https://publications.waset.org/abstracts/search?q=Dagmar%20Drobietz"> Dagmar Drobietz</a>, <a href="https://publications.waset.org/abstracts/search?q=Dietrich%20Kohlheyer"> Dietrich Kohlheyer</a>, <a href="https://publications.waset.org/abstracts/search?q=Anita%20Loeschcke"> Anita Loeschcke</a>, <a href="https://publications.waset.org/abstracts/search?q=Karl%20Erich%20Jaeger"> Karl Erich Jaeger</a>, <a href="https://publications.waset.org/abstracts/search?q=Thomas%20Drepper"> Thomas Drepper</a>, <a href="https://publications.waset.org/abstracts/search?q=Joerg%20Pietruszka"> Joerg Pietruszka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Light absorbing chromophoric systems are important optogenetic tools for biotechnical and biophysical investigations. Processes such as fluorescence or photolysis can be triggered by light-absorption of chromophores. These play a central role in life science. Photocaged compounds belong to such chromophoric systems. The photo-labile protecting groups enable them to release biologically active substances with high temporal and spatial resolution. The properties of photocaged compounds are specified by the characteristics of the caging group as well as the characteristics of the linked effector molecule. In our research, we work with different types of photo-labile protecting groups and various effector molecules giving us possible access to a large library of caged compounds. As a function of the caged effector molecule, a nearly limitless number of biological systems can be directed. Our main interest focusses on photocaging carbohydrates (e.g. arabinose) and their derivatives as effector molecules. Based on these resulting photocaged compounds a precisely controlled photoinduced gene expression will give us access to studies of numerous biotechnological and synthetic biological applications. It could be shown, that the regulation of gene expression via light is possible with photocaged carbohydrates achieving a higher-order control over this processes. With the one-step cleavable photocaged carbohydrate, a homogeneous expression was achieved in comparison to free carbohydrates. <iframe src="https://publications.waset.org/abstracts/55557.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bacterial%20gene%20expression" title="bacterial gene expression">bacterial gene expression</a>, <a href="https://publications.waset.org/abstracts/search?q=biotechnology" title=" biotechnology"> biotechnology</a>, <a href="https://publications.waset.org/abstracts/search?q=caged%20compounds" title=" caged compounds"> caged compounds</a>, <a href="https://publications.waset.org/abstracts/search?q=carbohydrates" title=" carbohydrates"> carbohydrates</a>, <a href="https://publications.waset.org/abstracts/search?q=optogenetics" title=" optogenetics"> optogenetics</a>, <a href="https://publications.waset.org/abstracts/search?q=photo-removable%20protecting%20group" title=" photo-removable protecting group"> photo-removable protecting group</a> </p> <a href="https://publications.waset.org/abstracts/55557/photocaged-carbohydrates-versatile-tools-for-biotechnological-applications" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/55557.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">227</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" 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Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications