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class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://sfu.academia.edu/GhassanHamarneh">Ghassan Hamarneh</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Simon Fraser University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://umed.academia.edu/MaciejBanach"><img class="profile-avatar u-positionAbsolute" alt="Maciej Banach" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/781527/926542/1160097/s200_maciej.banach.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://umed.academia.edu/MaciejBanach">Maciej Banach</a><p class="suggested-user-card__user-info__subheader 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src="https://0.academia-photos.com/24846723/6724855/7595859/s200_garumma.feyissa.jpg_oh_50317d6eae2887a02885ad21337fedc7_oe_55652f32___gda___1429814415_279af1c50b9c99c8de29a7c2bd46a7ea" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://drexel.academia.edu/GarummaFeyissa">Garumma T Feyissa</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Drexel University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://louisville.academia.edu/AdelElmaghraby"><img class="profile-avatar u-positionAbsolute" alt="Adel S Elmaghraby" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/27108977/7648798/8582030/s200_adel.elmaghraby.jpg" 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social-profile-avatar-container"><a href="https://bg.academia.edu/RadmilaObrenovic"><img class="profile-avatar u-positionAbsolute" alt="Radmila Obrenovic" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/39887235/18685011/18642889/s200_radmila.obrenovic.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://bg.academia.edu/RadmilaObrenovic">Radmila Obrenovic</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Belgrade</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://jeffersonhospital.academia.edu/JoshuaMarks"><img class="profile-avatar u-positionAbsolute" border="0" alt="" 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Calgary</p></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="42758412" href="https://www.academia.edu/Documents/in/Medical_Research"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/GoranSamsioe","location":"/GoranSamsioe","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/GoranSamsioe","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Medical Research"]}" data-trace="false" data-dom-id="Pill-react-component-da039acb-ed61-4eb0-9643-5e85b796cc0f"></div> <div 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data-dom-id="Pill-react-component-77303d24-626b-4f09-8ca3-63e76f177aae"></div> <div id="Pill-react-component-77303d24-626b-4f09-8ca3-63e76f177aae"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Göran Samsioe</h3></div><div class="js-work-strip profile--work_container" data-work-id="75660518"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660518/Research_Environmental_Medicine_Tubular_and_Glomerular_Kidney_Effects_in_Swedish_Women_with_Low_Environmental_Cadmium_Exposure"><img alt="Research paper thumbnail of Research | Environmental Medicine Tubular and Glomerular Kidney Effects in Swedish Women with Low Environmental Cadmium Exposure" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660518/Research_Environmental_Medicine_Tubular_and_Glomerular_Kidney_Effects_in_Swedish_Women_with_Low_Environmental_Cadmium_Exposure">Research | Environmental Medicine Tubular and Glomerular Kidney Effects in Swedish Women with Low Environmental Cadmium Exposure</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cadmium is a well-known nephrotoxic agent in food and tobacco, but the exposure level that is cri...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cadmium is a well-known nephrotoxic agent in food and tobacco, but the exposure level that is critical for kidney effects in the general population is not defined. Within a population-based women’s health survey in southern Sweden (Women’s Health in the Lund Area, WHILA), we investigated cadmium exposure in relation to tubular and glomerular function, from 1999 through early 2000 in 820 women (71 % participation rate) 53–64 years of age. Multiple linear regression showed cadmium in blood (median, 0.38 µg/L) and urine (0.52 µg/L; density adjusted = 0.67 µg/g creatinine) to be significantly associated with effects on renal tubules (as indicated by increased levels of human complex-forming protein and N-acetyl-β-D-glucosaminidase in urine), after adjusting for age, body mass index, blood lead, diabetes, hypertension, and regular use of nephrotoxic drugs. The associations remained significant even at the low exposure in women who had never smoked. We also found associations with markers...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660518"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660518"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660518; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660518]").text(description); $(".js-view-count[data-work-id=75660518]").attr('title', description).tooltip(); 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</script> <div class="js-work-strip profile--work_container" data-work-id="75660517"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660517/Association_between_forearm_BMD_and_urinary_cadmium_U_Cd_adjusted_to_density"><img alt="Research paper thumbnail of Association between forearm BMD and urinary cadmium (U-Cd) adjusted to density" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660517/Association_between_forearm_BMD_and_urinary_cadmium_U_Cd_adjusted_to_density">Association between forearm BMD and urinary cadmium (U-Cd) adjusted to density</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Copyright information: Taken from &quot;Cadmium-Induced Effects on Bone in a Population-Based Stu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Copyright information: Taken from &quot;Cadmium-Induced Effects on Bone in a Population-Based Study of Women&quot;Environmental Health Perspectives 2006;114(6):830-834.Published online 2 Feb 2006PMCID:PMC1480481.This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article&#39;s original DOI</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660517"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660517"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660517; 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660512]").text(description); $(".js-view-count[data-work-id=75660512]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660512; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660512']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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} }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660510"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660510/Contingency_in_Teacher_Child_Emotional_State_Talk_during_Shared_Book_Reading_in_Early_Childhood_Classrooms"><img alt="Research paper thumbnail of Contingency in Teacher-Child Emotional State Talk during Shared Book Reading in Early Childhood Classrooms" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660510/Contingency_in_Teacher_Child_Emotional_State_Talk_during_Shared_Book_Reading_in_Early_Childhood_Classrooms">Contingency in Teacher-Child Emotional State Talk during Shared Book Reading in Early Childhood Classrooms</a></div><div class="wp-workCard_item"><span>Early Education and Development</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Research Findings: The aim of this study was to investigate emotional state talk between...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Research Findings: The aim of this study was to investigate emotional state talk between teachers and their students in 81 early childhood classrooms during shared book reading. Teachers shared with their students an experimental emotion narrative book. Preliminary analysis of teachers’ and children’s transcribed utterances during reading addressed the frequencies of emotional terms, form (question vs. comment), and content (emotion identification, emotion causality, emotion inference, or non-emotional content). Sequential analysis evaluated contingent relations between the book text and teachers’ comments and questions about emotions as well as between teachers’ and children’s contingent responses to each other. Results showed emotional excerpts from the book were significantly associated with teachers’ questions and comments about emotion identification. Children were highly specific and responsive to teachers’ emotional state talk, and children’s comments about emotions evoked further considerations from teachers about the same topics. Practice or Policy: Our results highlight the importance of the presence of emotional terms in the book text to stimulate emotional state talk. Given the value of emotional state talk for children’s emotional development, teachers must be informed of preschoolers’ ability to consistently participate in classroom discussions about emotions, even when complex topics like causality and inferences are addressed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660510"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660510"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660510; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660510]").text(description); $(".js-view-count[data-work-id=75660510]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660510; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660510']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="75660509"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/75660509/Primary_screening_for_increased_fracture_risk_by_the_FRAX_questionnaire_uptake_rates_in_relation_to_invitation_method"><img alt="Research paper thumbnail of Primary screening for increased fracture risk by the FRAX® questionnaire—uptake rates in relation to invitation method" class="work-thumbnail" src="https://attachments.academia-assets.com/83341388/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/75660509/Primary_screening_for_increased_fracture_risk_by_the_FRAX_questionnaire_uptake_rates_in_relation_to_invitation_method">Primary screening for increased fracture risk by the FRAX® questionnaire—uptake rates in relation to invitation method</a></div><div class="wp-workCard_item"><span>Archives of Osteoporosis</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of the study was to evaluate the feasibility and most efficient way of offering middle-ag...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of the study was to evaluate the feasibility and most efficient way of offering middle-aged Swedish women a primary fracture screening program via a questionnaire. Two out of five invited women returned the FRAX questionnaire and those contacted directly by mail were most prone to respond. Purpose Osteoporosis and its associated fractures are increasing, and this study aims to explore ways to identify women at an increased risk of fracture using the FRAX® algorithm. Methods Three thousand middle-aged women were invited and presented a questionnaire distributed by three different methodsby mail, at routine mammography, or internet-based. Results In total, 1120 (37.3%) women responded to the questionnaire and agreed to participate. The response rates for the mail, mammography, and internet-based groups were 39.1%, 35.7%, and 25.2% respectively. Women in the mammography group weighed more, were slightly older than the other women, and also had a higher BMI than women from the mail and internetbased groups. No difference was observed between the groups regarding previous fracture, family history for fracture, current smoking, glucocorticoid use, and alcohol usage. The mammography group had a higher median (interquartile range) major osteoporotic FRAX® score (10.0% (7.8-17.0)) than the mail group (9.7% (7.1-15.0); p = 0.005) and the internet-based group (8.7% (6.7-14.0); p = 0.001). Conclusions Two out of five early postmenopausal women returned the questionnaire and women contacted directly by mail were more prone to respond. Out of the participants, 26.6% had a 10-year fracture risk score ≥ 15% according to the FRAX® algorithm.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="aea25f6ea25a072962ae70c7cbbec822" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83341388,"asset_id":75660509,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83341388/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660509"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660509"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660509; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660509]").text(description); $(".js-view-count[data-work-id=75660509]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660509; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660509']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660508"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660508/Routes_of_HRT_Administration_When_to_Use_Oral_or_Transdermal_Administration"><img alt="Research paper thumbnail of Routes of HRT Administration. When to Use Oral or Transdermal Administration" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660508/Routes_of_HRT_Administration_When_to_Use_Oral_or_Transdermal_Administration">Routes of HRT Administration. When to Use Oral or Transdermal Administration</a></div><div class="wp-workCard_item"><span>Medical Science Symposia Series</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">As with most pharmacologic agents, estrogens and progestogens can be administered by several mode...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">As with most pharmacologic agents, estrogens and progestogens can be administered by several modes of administration. Indeed such steroids could be given as eye drops, intranasal spray, tablets, transdermal patches, transdermal cream, implants, depo injections, intrauterine devices, vaginal pessaries, or suppositories.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660508"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660508"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660508; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660508]").text(description); $(".js-view-count[data-work-id=75660508]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660508; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660508']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=75660508]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75660508,"title":"Routes of HRT Administration. When to Use Oral or Transdermal Administration","internal_url":"https://www.academia.edu/75660508/Routes_of_HRT_Administration_When_to_Use_Oral_or_Transdermal_Administration","owner_id":42758412,"coauthors_can_edit":true,"owner":{"id":42758412,"first_name":"Göran","middle_initials":null,"last_name":"Samsioe","page_name":"GoranSamsioe","domain_name":"independent","created_at":"2016-02-06T02:51:22.678-08:00","display_name":"Göran Samsioe","url":"https://independent.academia.edu/GoranSamsioe"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660507"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660507/Lipid_metabolism_in_women_with_polycystic_ovary_syndrome_possible_implications_for_an_increased_risk_of_coronary_heart_disease_Supported_by_grants_from_the_G%C3%B6teborg_Medical_Society_The_Medical_Faculty_University_of_G%C3%B6teborg_and_Organon_Oss_The_Netherlands"><img alt="Research paper thumbnail of Lipid metabolism in women with polycystic ovary syndrome: possible implications for an increased risk of coronary heart disease**Supported by grants from the Göteborg Medical Society, The Medical Faculty, University of Göteborg, and Organon, Oss, The Netherlands" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660507/Lipid_metabolism_in_women_with_polycystic_ovary_syndrome_possible_implications_for_an_increased_risk_of_coronary_heart_disease_Supported_by_grants_from_the_G%C3%B6teborg_Medical_Society_The_Medical_Faculty_University_of_G%C3%B6teborg_and_Organon_Oss_The_Netherlands">Lipid metabolism in women with polycystic ovary syndrome: possible implications for an increased risk of coronary heart disease**Supported by grants from the Göteborg Medical Society, The Medical Faculty, University of Göteborg, and Organon, Oss, The Netherlands</a></div><div class="wp-workCard_item"><span>Fertility and Sterility</span><span>, 1984</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This study reports values of serum lipids, lipoproteins, and the relative fatty acid composition ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This study reports values of serum lipids, lipoproteins, and the relative fatty acid composition of lecithin and cholesterol ester in 20 women with typical polycystic ovary syndrome (PCO). These values were compared with values of 22 regularly menstruating women without clinical evidence of androgen excess. Higher levels of triglycerides in serum (P less than 0.05) and very low-density lipoproteins (P less than 0.01) and lower concentrations of free cholesterol in low-density lipoproteins (P less than 0.05) were found in the PCO women. In serum lecithin the PCO patients had higher palmitic and lower stearic acid levels compared with those of the normal women. This finding was interpreted as a reduction of the excretory capacity of the liver in the PCO group. No correlations between lipids and sex hormones were found. Body weights and blood pressures were higher in the PCO group. The results indicate that PCO women could be at increased risk for coronary heart disease, because an increased serum triglyceride level, body weight, and blood pressure are considered to be risk factors of coronary heart disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660507"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660507"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660507; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660507]").text(description); $(".js-view-count[data-work-id=75660507]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660507; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660507']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=75660507]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75660507,"title":"Lipid metabolism in women with polycystic ovary syndrome: possible implications for an increased risk of coronary heart disease**Supported by grants from the Göteborg Medical Society, The Medical Faculty, University of Göteborg, and Organon, Oss, The Netherlands","internal_url":"https://www.academia.edu/75660507/Lipid_metabolism_in_women_with_polycystic_ovary_syndrome_possible_implications_for_an_increased_risk_of_coronary_heart_disease_Supported_by_grants_from_the_G%C3%B6teborg_Medical_Society_The_Medical_Faculty_University_of_G%C3%B6teborg_and_Organon_Oss_The_Netherlands","owner_id":42758412,"coauthors_can_edit":true,"owner":{"id":42758412,"first_name":"Göran","middle_initials":null,"last_name":"Samsioe","page_name":"GoranSamsioe","domain_name":"independent","created_at":"2016-02-06T02:51:22.678-08:00","display_name":"Göran Samsioe","url":"https://independent.academia.edu/GoranSamsioe"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660506"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660506/Cardioprotection_by_Hormone_Replacement_Therapy"><img alt="Research paper thumbnail of Cardioprotection by Hormone Replacement Therapy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660506/Cardioprotection_by_Hormone_Replacement_Therapy">Cardioprotection by Hormone Replacement Therapy</a></div><div class="wp-workCard_item"><span>Hormonal Carcinogenesis II</span><span>, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cardiovascular disease, especially myocardial infarction, is more common in men than in women bef...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cardiovascular disease, especially myocardial infarction, is more common in men than in women before the age of fifty. Oophorectomy in premenopausal women leads to an increase in cardiovascular morbidity and mortality (1, 2). Based on these observations, it can be inferred that female gonadal hormones may confer protection against cardiovascular disease irrespective of age (3). Experimental studies on several risk factors of cardiovascular disease carried out in both animals and humans further support this notion. These observations provide the rationale for exogenous estrogen administration in order to reduce cardiovascular disease in women.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660506"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660506"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660506; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660506]").text(description); $(".js-view-count[data-work-id=75660506]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660506; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660506']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=75660506]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75660506,"title":"Cardioprotection by Hormone Replacement Therapy","internal_url":"https://www.academia.edu/75660506/Cardioprotection_by_Hormone_Replacement_Therapy","owner_id":42758412,"coauthors_can_edit":true,"owner":{"id":42758412,"first_name":"Göran","middle_initials":null,"last_name":"Samsioe","page_name":"GoranSamsioe","domain_name":"independent","created_at":"2016-02-06T02:51:22.678-08:00","display_name":"Göran Samsioe","url":"https://independent.academia.edu/GoranSamsioe"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660505"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660505/Estrogen_based_treatments_for_genitourinary_syndrome"><img alt="Research paper thumbnail of Estrogen based treatments for genitourinary syndrome" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660505/Estrogen_based_treatments_for_genitourinary_syndrome">Estrogen based treatments for genitourinary syndrome</a></div><div class="wp-workCard_item"><span>Maturitas</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">condition to enjoy enhanced health, well-being and quality of life. Moreover, these options are a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">condition to enjoy enhanced health, well-being and quality of life. Moreover, these options are accompanied by important cost reductions in pharmaceutical investment and healthcare. Nevertheless, several issues remain controversial or have scarcely been investigated, and additional high-quality research should address these issues properly in the future. Thus, we encourage women-focused institutions and policies (e.g., healthcare centres, public organisations andwomen’s associations) tooffer psychosocial interventions to periand postmenopausal women within a comprehensive healthcare paradigm.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660505"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660505"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660505; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660505]").text(description); $(".js-view-count[data-work-id=75660505]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660505; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660505']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=75660505]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75660505,"title":"Estrogen based treatments for genitourinary syndrome","internal_url":"https://www.academia.edu/75660505/Estrogen_based_treatments_for_genitourinary_syndrome","owner_id":42758412,"coauthors_can_edit":true,"owner":{"id":42758412,"first_name":"Göran","middle_initials":null,"last_name":"Samsioe","page_name":"GoranSamsioe","domain_name":"independent","created_at":"2016-02-06T02:51:22.678-08:00","display_name":"Göran Samsioe","url":"https://independent.academia.edu/GoranSamsioe"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660504"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/75660504/Medication_Use_of_European_Women_Seeking_Treatment_for_Ui_Findings_from_the_Pure_Observational_Study"><img alt="Research paper thumbnail of Medication Use of European Women Seeking Treatment for Ui: Findings from the Pure Observational Study" class="work-thumbnail" src="https://attachments.academia-assets.com/83341449/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/75660504/Medication_Use_of_European_Women_Seeking_Treatment_for_Ui_Findings_from_the_Pure_Observational_Study">Medication Use of European Women Seeking Treatment for Ui: Findings from the Pure Observational Study</a></div><div class="wp-workCard_item"><span>European Urology Supplements</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We performed a large cohort study to assess the prognostic relevance of grade, stage, focality, d...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We performed a large cohort study to assess the prognostic relevance of grade, stage, focality, dimension, KI67 immunostaining and p53 immunostaining to predict the overall, cause-specifi c and progression free survival of patients with superfi cial bladder cancer. MATERIAL & METHODS: Since 1990 data regarding KI67, p53 have been collected in all patients with a diagnosis of superfi cial (Ta-T1), intermediate or high risk (G2-G3, multifocal or more than 2 cm in diameter) bladder cancer. All the patients have been treated with at least one course of 6 intravesical instillations with BCG. All the surgical specimens from TURBT have been examined by a single pathology team. The main end points were: overall survival, cause specifi c survival and progression free survival. The Log Rank test was used to compare the survival curves in the univariate analysis and the Cox regression model to weight the prognostic factors in the multivariate analysis. RESULTS: 345 patients, median age 72 (31-93) years, median follow-up 34 (1-170) months. 322 patients had a intermediate or high risk superfi cial bladder cancer, 23 had an in-situ carcinoma. Median KI67 was 22.5% (1-80), median p53 was 6% (0-80). During the follow-up time 38 patients had a progression to muscle invasive disease. The univariate statistical analysis showed signifi cant difference in overall survival between G2 versus G3 tumours. In cause specifi c survival the differences were between Ta and CIS versus T1 tumours. In progression free survival we found signifi cant differences between G2 versus G3, Ta and CIS versus T1, KI67 < 17% versus KI67 > 17% and tumours smaller than 2 cm versus tumours bigger than 2 cm. No prognostic relevance was found for p53 and focality. The multivariate analysis confi rmed an independent prognostic value for grade on overall survival; for grade and stage on cause specifi c survival; for grade, stage and KI67 on progression free survival. CONCLUSIONS: We analysed a huge sample of patients with intermediate or high risk superfi cial bladder cancer followed for a long period and treated in a homogeneous way. We found independent and signifi cant prognostic value for stage, grade, KI67 status and dimension of tumours in predicting the risk of progression to muscle invasive disease. Stage and grade remain the only characteristics able to predict cause specifi c survival.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="229be1259e919d89a423b8afca1e08cc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83341449,"asset_id":75660504,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83341449/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660504"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660504"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660504; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660503"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/75660503/The_relative_fatty_acid_composition_of_serum_lecithin_and_cholesterol_ester_Influence_of_an_estrogen_progestogen_regimen_in_climacteric_women"><img alt="Research paper thumbnail of The relative fatty acid composition of serum lecithin and cholesterol ester: Influence of an estrogen-progestogen regimen in climacteric women" class="work-thumbnail" src="https://attachments.academia-assets.com/83341537/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/75660503/The_relative_fatty_acid_composition_of_serum_lecithin_and_cholesterol_ester_Influence_of_an_estrogen_progestogen_regimen_in_climacteric_women">The relative fatty acid composition of serum lecithin and cholesterol ester: Influence of an estrogen-progestogen regimen in climacteric women</a></div><div class="wp-workCard_item"><span>American Journal of Obstetrics and Gynecology</span><span>, 1986</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Inoue et a!. and motor activity patterns in the newborn infant and the fetus antepartum-a compara...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Inoue et a!. and motor activity patterns in the newborn infant and the fetus antepartum-a comparative study. I. Technique, illustration of recordings and general results.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="0309bc3a04c3f5d6dcda56603ccc24ca" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83341537,"asset_id":75660503,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83341537/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660503"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660503"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660503; 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Changes in lipid- and lipoprotein metabolism induced by high doses of medroxyprogesterone acetate (MPA)" class="work-thumbnail" src="https://attachments.academia-assets.com/83341447/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/75660499/266_Changes_in_lipid_and_lipoprotein_metabolism_induced_by_high_doses_of_medroxyprogesterone_acetate_MPA_">266. Changes in lipid- and lipoprotein metabolism induced by high doses of medroxyprogesterone acetate (MPA)</a></div><div class="wp-workCard_item"><span>Journal of Steroid Biochemistry</span><span>, 1982</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="daefc9c28ff912ce9c0135d7ff29433a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83341447,"asset_id":75660499,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83341447/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660499"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660499"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660499; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660499]").text(description); $(".js-view-count[data-work-id=75660499]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660499; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660499']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "daefc9c28ff912ce9c0135d7ff29433a" } } $('.js-work-strip[data-work-id=75660499]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75660499,"title":"266. Changes in lipid- and lipoprotein metabolism induced by high doses of medroxyprogesterone acetate (MPA)","internal_url":"https://www.academia.edu/75660499/266_Changes_in_lipid_and_lipoprotein_metabolism_induced_by_high_doses_of_medroxyprogesterone_acetate_MPA_","owner_id":42758412,"coauthors_can_edit":true,"owner":{"id":42758412,"first_name":"Göran","middle_initials":null,"last_name":"Samsioe","page_name":"GoranSamsioe","domain_name":"independent","created_at":"2016-02-06T02:51:22.678-08:00","display_name":"Göran Samsioe","url":"https://independent.academia.edu/GoranSamsioe"},"attachments":[{"id":83341447,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/83341447/thumbnails/1.jpg","file_name":"0022-4731_2882_2990480-020220406-32623-jyps41.pdf","download_url":"https://www.academia.edu/attachments/83341447/download_file","bulk_download_file_name":"266_Changes_in_lipid_and_lipoprotein_met.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/83341447/0022-4731_2882_2990480-020220406-32623-jyps41-libre.pdf?1649280308=\u0026response-content-disposition=attachment%3B+filename%3D266_Changes_in_lipid_and_lipoprotein_met.pdf\u0026Expires=1739757514\u0026Signature=gCgHCh-yBc1OmCkE4IT7mb-Z2QTxVvQ39J9AQa1-zWSH1S-Tp6Oatoqzf-lfQP1C6V6lgRP8XZ9v6UHV1IssPs4~fBfJN6Ly16-eishVhG2JTopQeobVze0va1tqjNPLz98WG3kXgGzpcjjtn34vg0YTozzVQEKrhW6htcvn2HxD1JX6SrD~hdIFGuDRtjo-wm9WB0sL~Fn0JFc7262GqGb5AHt-PK4iEJoRBhBfDIWRRRqnZtzJbu3r0D5wMVN-USSusKYz37cJdmuUwW~01nqFL8UCiejrw7hteTNNdKUUe0BxRtfI~-oiRd67ROZZes-pfTsBdIcXl05G39siZg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660496"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660496/Could_quality_of_life_impact_the_prevalence_of_metabolic_syndrome_Results_from_a_population_based_study_of_Swedish_women_the_Womens_Health_in_the_Lund_Area_Study"><img alt="Research paper thumbnail of Could quality of life impact the prevalence of metabolic syndrome? Results from a population-based study of Swedish women: the Women's Health in the Lund Area Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660496/Could_quality_of_life_impact_the_prevalence_of_metabolic_syndrome_Results_from_a_population_based_study_of_Swedish_women_the_Womens_Health_in_the_Lund_Area_Study">Could quality of life impact the prevalence of metabolic syndrome? Results from a population-based study of Swedish women: the Women's Health in the Lund Area Study</a></div><div class="wp-workCard_item"><span>Metabolic syndrome and related disorders</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The metabolic syndrome is regarded as an important risk factor for diabetes mellitus and cardiova...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The metabolic syndrome is regarded as an important risk factor for diabetes mellitus and cardiovascular disease. Metabolic syndrome could be associated with impaired quality of life (QoL). The Women&#39;s Health in the Lund Area (WHILA) project covers 10,766 women born between December 2, 1935, and December 1, 1945, living in the Lund area, of Sweden by December 1, 1995. The primary objectives of this project were to survey perimenopausal women in this area and to evaluate their health status and lifestyles. We used the criteria for the metabolic syndrome, as defined by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III), which include three or more of five risk factors: central obesity, elevated serum triglycerides, low high-density lipoprotein cholesterol (HDL-C), and elevated blood pressure and fasting glucose. Analysis of most aspects of daily life and QoL according to the Gothenburg Quality of Life Instrument (GQL) was done. GQL refers to the W...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660496"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660496"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660496; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660496]").text(description); $(".js-view-count[data-work-id=75660496]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660496; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660496']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=75660496]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75660496,"title":"Could quality of life impact the prevalence of metabolic syndrome? Results from a population-based study of Swedish women: the Women's Health in the Lund Area Study","internal_url":"https://www.academia.edu/75660496/Could_quality_of_life_impact_the_prevalence_of_metabolic_syndrome_Results_from_a_population_based_study_of_Swedish_women_the_Womens_Health_in_the_Lund_Area_Study","owner_id":42758412,"coauthors_can_edit":true,"owner":{"id":42758412,"first_name":"Göran","middle_initials":null,"last_name":"Samsioe","page_name":"GoranSamsioe","domain_name":"independent","created_at":"2016-02-06T02:51:22.678-08:00","display_name":"Göran Samsioe","url":"https://independent.academia.edu/GoranSamsioe"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660494"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/75660494/Characteristics_of_European_Women_Consulting_a_Physician_for_the_First_Time_Results_from_the_Pure_Study_on_Urinary_Incontinence"><img alt="Research paper thumbnail of Characteristics of European Women Consulting a Physician for the First Time: Results from the Pure Study on Urinary Incontinence" class="work-thumbnail" src="https://attachments.academia-assets.com/83341452/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/75660494/Characteristics_of_European_Women_Consulting_a_Physician_for_the_First_Time_Results_from_the_Pure_Study_on_Urinary_Incontinence">Characteristics of European Women Consulting a Physician for the First Time: Results from the Pure Study on Urinary Incontinence</a></div><div class="wp-workCard_item"><span>European Urology Supplements</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We performed a large cohort study to assess the prognostic relevance of grade, stage, focality, d...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We performed a large cohort study to assess the prognostic relevance of grade, stage, focality, dimension, KI67 immunostaining and p53 immunostaining to predict the overall, cause-specifi c and progression free survival of patients with superfi cial bladder cancer. MATERIAL & METHODS: Since 1990 data regarding KI67, p53 have been collected in all patients with a diagnosis of superfi cial (Ta-T1), intermediate or high risk (G2-G3, multifocal or more than 2 cm in diameter) bladder cancer. All the patients have been treated with at least one course of 6 intravesical instillations with BCG. All the surgical specimens from TURBT have been examined by a single pathology team. The main end points were: overall survival, cause specifi c survival and progression free survival. The Log Rank test was used to compare the survival curves in the univariate analysis and the Cox regression model to weight the prognostic factors in the multivariate analysis. RESULTS: 345 patients, median age 72 (31-93) years, median follow-up 34 (1-170) months. 322 patients had a intermediate or high risk superfi cial bladder cancer, 23 had an in-situ carcinoma. Median KI67 was 22.5% (1-80), median p53 was 6% (0-80). During the follow-up time 38 patients had a progression to muscle invasive disease. The univariate statistical analysis showed signifi cant difference in overall survival between G2 versus G3 tumours. In cause specifi c survival the differences were between Ta and CIS versus T1 tumours. In progression free survival we found signifi cant differences between G2 versus G3, Ta and CIS versus T1, KI67 < 17% versus KI67 > 17% and tumours smaller than 2 cm versus tumours bigger than 2 cm. No prognostic relevance was found for p53 and focality. The multivariate analysis confi rmed an independent prognostic value for grade on overall survival; for grade and stage on cause specifi c survival; for grade, stage and KI67 on progression free survival. CONCLUSIONS: We analysed a huge sample of patients with intermediate or high risk superfi cial bladder cancer followed for a long period and treated in a homogeneous way. We found independent and signifi cant prognostic value for stage, grade, KI67 status and dimension of tumours in predicting the risk of progression to muscle invasive disease. Stage and grade remain the only characteristics able to predict cause specifi c survival.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a9a8d29eb058b91b68b30a526ab4143d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83341452,"asset_id":75660494,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83341452/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660494"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660494"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660494; 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Within a population-based women’s health survey in southern Sweden (Women’s Health in the Lund Area, WHILA), we investigated cadmium exposure in relation to tubular and glomerular function, from 1999 through early 2000 in 820 women (71 % participation rate) 53–64 years of age. Multiple linear regression showed cadmium in blood (median, 0.38 µg/L) and urine (0.52 µg/L; density adjusted = 0.67 µg/g creatinine) to be significantly associated with effects on renal tubules (as indicated by increased levels of human complex-forming protein and N-acetyl-β-D-glucosaminidase in urine), after adjusting for age, body mass index, blood lead, diabetes, hypertension, and regular use of nephrotoxic drugs. The associations remained significant even at the low exposure in women who had never smoked. We also found associations with markers...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660518"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660518"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660518; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660518]").text(description); $(".js-view-count[data-work-id=75660518]").attr('title', description).tooltip(); 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</script> <div class="js-work-strip profile--work_container" data-work-id="75660517"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660517/Association_between_forearm_BMD_and_urinary_cadmium_U_Cd_adjusted_to_density"><img alt="Research paper thumbnail of Association between forearm BMD and urinary cadmium (U-Cd) adjusted to density" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660517/Association_between_forearm_BMD_and_urinary_cadmium_U_Cd_adjusted_to_density">Association between forearm BMD and urinary cadmium (U-Cd) adjusted to density</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Copyright information: Taken from &quot;Cadmium-Induced Effects on Bone in a Population-Based Stu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Copyright information: Taken from &quot;Cadmium-Induced Effects on Bone in a Population-Based Study of Women&quot;Environmental Health Perspectives 2006;114(6):830-834.Published online 2 Feb 2006PMCID:PMC1480481.This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article&#39;s original DOI</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660517"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660517"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660517; 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660512]").text(description); $(".js-view-count[data-work-id=75660512]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660512; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660512']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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} }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660510"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660510/Contingency_in_Teacher_Child_Emotional_State_Talk_during_Shared_Book_Reading_in_Early_Childhood_Classrooms"><img alt="Research paper thumbnail of Contingency in Teacher-Child Emotional State Talk during Shared Book Reading in Early Childhood Classrooms" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660510/Contingency_in_Teacher_Child_Emotional_State_Talk_during_Shared_Book_Reading_in_Early_Childhood_Classrooms">Contingency in Teacher-Child Emotional State Talk during Shared Book Reading in Early Childhood Classrooms</a></div><div class="wp-workCard_item"><span>Early Education and Development</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT Research Findings: The aim of this study was to investigate emotional state talk between...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">ABSTRACT Research Findings: The aim of this study was to investigate emotional state talk between teachers and their students in 81 early childhood classrooms during shared book reading. Teachers shared with their students an experimental emotion narrative book. Preliminary analysis of teachers’ and children’s transcribed utterances during reading addressed the frequencies of emotional terms, form (question vs. comment), and content (emotion identification, emotion causality, emotion inference, or non-emotional content). Sequential analysis evaluated contingent relations between the book text and teachers’ comments and questions about emotions as well as between teachers’ and children’s contingent responses to each other. Results showed emotional excerpts from the book were significantly associated with teachers’ questions and comments about emotion identification. Children were highly specific and responsive to teachers’ emotional state talk, and children’s comments about emotions evoked further considerations from teachers about the same topics. Practice or Policy: Our results highlight the importance of the presence of emotional terms in the book text to stimulate emotional state talk. Given the value of emotional state talk for children’s emotional development, teachers must be informed of preschoolers’ ability to consistently participate in classroom discussions about emotions, even when complex topics like causality and inferences are addressed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660510"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660510"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660510; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660510]").text(description); $(".js-view-count[data-work-id=75660510]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660510; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660510']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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</script> <div class="js-work-strip profile--work_container" data-work-id="75660509"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/75660509/Primary_screening_for_increased_fracture_risk_by_the_FRAX_questionnaire_uptake_rates_in_relation_to_invitation_method"><img alt="Research paper thumbnail of Primary screening for increased fracture risk by the FRAX® questionnaire—uptake rates in relation to invitation method" class="work-thumbnail" src="https://attachments.academia-assets.com/83341388/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/75660509/Primary_screening_for_increased_fracture_risk_by_the_FRAX_questionnaire_uptake_rates_in_relation_to_invitation_method">Primary screening for increased fracture risk by the FRAX® questionnaire—uptake rates in relation to invitation method</a></div><div class="wp-workCard_item"><span>Archives of Osteoporosis</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of the study was to evaluate the feasibility and most efficient way of offering middle-ag...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of the study was to evaluate the feasibility and most efficient way of offering middle-aged Swedish women a primary fracture screening program via a questionnaire. Two out of five invited women returned the FRAX questionnaire and those contacted directly by mail were most prone to respond. Purpose Osteoporosis and its associated fractures are increasing, and this study aims to explore ways to identify women at an increased risk of fracture using the FRAX® algorithm. Methods Three thousand middle-aged women were invited and presented a questionnaire distributed by three different methodsby mail, at routine mammography, or internet-based. Results In total, 1120 (37.3%) women responded to the questionnaire and agreed to participate. The response rates for the mail, mammography, and internet-based groups were 39.1%, 35.7%, and 25.2% respectively. Women in the mammography group weighed more, were slightly older than the other women, and also had a higher BMI than women from the mail and internetbased groups. No difference was observed between the groups regarding previous fracture, family history for fracture, current smoking, glucocorticoid use, and alcohol usage. The mammography group had a higher median (interquartile range) major osteoporotic FRAX® score (10.0% (7.8-17.0)) than the mail group (9.7% (7.1-15.0); p = 0.005) and the internet-based group (8.7% (6.7-14.0); p = 0.001). Conclusions Two out of five early postmenopausal women returned the questionnaire and women contacted directly by mail were more prone to respond. Out of the participants, 26.6% had a 10-year fracture risk score ≥ 15% according to the FRAX® algorithm.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="aea25f6ea25a072962ae70c7cbbec822" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83341388,"asset_id":75660509,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83341388/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660509"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660509"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660509; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660509]").text(description); $(".js-view-count[data-work-id=75660509]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660509; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660509']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660508"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660508/Routes_of_HRT_Administration_When_to_Use_Oral_or_Transdermal_Administration"><img alt="Research paper thumbnail of Routes of HRT Administration. When to Use Oral or Transdermal Administration" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660508/Routes_of_HRT_Administration_When_to_Use_Oral_or_Transdermal_Administration">Routes of HRT Administration. When to Use Oral or Transdermal Administration</a></div><div class="wp-workCard_item"><span>Medical Science Symposia Series</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">As with most pharmacologic agents, estrogens and progestogens can be administered by several mode...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">As with most pharmacologic agents, estrogens and progestogens can be administered by several modes of administration. Indeed such steroids could be given as eye drops, intranasal spray, tablets, transdermal patches, transdermal cream, implants, depo injections, intrauterine devices, vaginal pessaries, or suppositories.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660508"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660508"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660508; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660508]").text(description); $(".js-view-count[data-work-id=75660508]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660508; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660508']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=75660508]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75660508,"title":"Routes of HRT Administration. When to Use Oral or Transdermal Administration","internal_url":"https://www.academia.edu/75660508/Routes_of_HRT_Administration_When_to_Use_Oral_or_Transdermal_Administration","owner_id":42758412,"coauthors_can_edit":true,"owner":{"id":42758412,"first_name":"Göran","middle_initials":null,"last_name":"Samsioe","page_name":"GoranSamsioe","domain_name":"independent","created_at":"2016-02-06T02:51:22.678-08:00","display_name":"Göran Samsioe","url":"https://independent.academia.edu/GoranSamsioe"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660507"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660507/Lipid_metabolism_in_women_with_polycystic_ovary_syndrome_possible_implications_for_an_increased_risk_of_coronary_heart_disease_Supported_by_grants_from_the_G%C3%B6teborg_Medical_Society_The_Medical_Faculty_University_of_G%C3%B6teborg_and_Organon_Oss_The_Netherlands"><img alt="Research paper thumbnail of Lipid metabolism in women with polycystic ovary syndrome: possible implications for an increased risk of coronary heart disease**Supported by grants from the Göteborg Medical Society, The Medical Faculty, University of Göteborg, and Organon, Oss, The Netherlands" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660507/Lipid_metabolism_in_women_with_polycystic_ovary_syndrome_possible_implications_for_an_increased_risk_of_coronary_heart_disease_Supported_by_grants_from_the_G%C3%B6teborg_Medical_Society_The_Medical_Faculty_University_of_G%C3%B6teborg_and_Organon_Oss_The_Netherlands">Lipid metabolism in women with polycystic ovary syndrome: possible implications for an increased risk of coronary heart disease**Supported by grants from the Göteborg Medical Society, The Medical Faculty, University of Göteborg, and Organon, Oss, The Netherlands</a></div><div class="wp-workCard_item"><span>Fertility and Sterility</span><span>, 1984</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This study reports values of serum lipids, lipoproteins, and the relative fatty acid composition ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This study reports values of serum lipids, lipoproteins, and the relative fatty acid composition of lecithin and cholesterol ester in 20 women with typical polycystic ovary syndrome (PCO). These values were compared with values of 22 regularly menstruating women without clinical evidence of androgen excess. Higher levels of triglycerides in serum (P less than 0.05) and very low-density lipoproteins (P less than 0.01) and lower concentrations of free cholesterol in low-density lipoproteins (P less than 0.05) were found in the PCO women. In serum lecithin the PCO patients had higher palmitic and lower stearic acid levels compared with those of the normal women. This finding was interpreted as a reduction of the excretory capacity of the liver in the PCO group. No correlations between lipids and sex hormones were found. Body weights and blood pressures were higher in the PCO group. The results indicate that PCO women could be at increased risk for coronary heart disease, because an increased serum triglyceride level, body weight, and blood pressure are considered to be risk factors of coronary heart disease.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660507"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660507"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660507; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660507]").text(description); $(".js-view-count[data-work-id=75660507]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660507; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660507']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=75660507]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75660507,"title":"Lipid metabolism in women with polycystic ovary syndrome: possible implications for an increased risk of coronary heart disease**Supported by grants from the Göteborg Medical Society, The Medical Faculty, University of Göteborg, and Organon, Oss, The Netherlands","internal_url":"https://www.academia.edu/75660507/Lipid_metabolism_in_women_with_polycystic_ovary_syndrome_possible_implications_for_an_increased_risk_of_coronary_heart_disease_Supported_by_grants_from_the_G%C3%B6teborg_Medical_Society_The_Medical_Faculty_University_of_G%C3%B6teborg_and_Organon_Oss_The_Netherlands","owner_id":42758412,"coauthors_can_edit":true,"owner":{"id":42758412,"first_name":"Göran","middle_initials":null,"last_name":"Samsioe","page_name":"GoranSamsioe","domain_name":"independent","created_at":"2016-02-06T02:51:22.678-08:00","display_name":"Göran Samsioe","url":"https://independent.academia.edu/GoranSamsioe"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660506"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660506/Cardioprotection_by_Hormone_Replacement_Therapy"><img alt="Research paper thumbnail of Cardioprotection by Hormone Replacement Therapy" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660506/Cardioprotection_by_Hormone_Replacement_Therapy">Cardioprotection by Hormone Replacement Therapy</a></div><div class="wp-workCard_item"><span>Hormonal Carcinogenesis II</span><span>, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cardiovascular disease, especially myocardial infarction, is more common in men than in women bef...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cardiovascular disease, especially myocardial infarction, is more common in men than in women before the age of fifty. Oophorectomy in premenopausal women leads to an increase in cardiovascular morbidity and mortality (1, 2). Based on these observations, it can be inferred that female gonadal hormones may confer protection against cardiovascular disease irrespective of age (3). Experimental studies on several risk factors of cardiovascular disease carried out in both animals and humans further support this notion. These observations provide the rationale for exogenous estrogen administration in order to reduce cardiovascular disease in women.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660506"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660506"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660506; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660506]").text(description); $(".js-view-count[data-work-id=75660506]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660506; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660506']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=75660506]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75660506,"title":"Cardioprotection by Hormone Replacement Therapy","internal_url":"https://www.academia.edu/75660506/Cardioprotection_by_Hormone_Replacement_Therapy","owner_id":42758412,"coauthors_can_edit":true,"owner":{"id":42758412,"first_name":"Göran","middle_initials":null,"last_name":"Samsioe","page_name":"GoranSamsioe","domain_name":"independent","created_at":"2016-02-06T02:51:22.678-08:00","display_name":"Göran Samsioe","url":"https://independent.academia.edu/GoranSamsioe"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660505"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660505/Estrogen_based_treatments_for_genitourinary_syndrome"><img alt="Research paper thumbnail of Estrogen based treatments for genitourinary syndrome" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660505/Estrogen_based_treatments_for_genitourinary_syndrome">Estrogen based treatments for genitourinary syndrome</a></div><div class="wp-workCard_item"><span>Maturitas</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">condition to enjoy enhanced health, well-being and quality of life. Moreover, these options are a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">condition to enjoy enhanced health, well-being and quality of life. Moreover, these options are accompanied by important cost reductions in pharmaceutical investment and healthcare. Nevertheless, several issues remain controversial or have scarcely been investigated, and additional high-quality research should address these issues properly in the future. Thus, we encourage women-focused institutions and policies (e.g., healthcare centres, public organisations andwomen’s associations) tooffer psychosocial interventions to periand postmenopausal women within a comprehensive healthcare paradigm.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660505"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660505"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660505; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660505]").text(description); $(".js-view-count[data-work-id=75660505]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660505; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660505']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=75660505]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75660505,"title":"Estrogen based treatments for genitourinary syndrome","internal_url":"https://www.academia.edu/75660505/Estrogen_based_treatments_for_genitourinary_syndrome","owner_id":42758412,"coauthors_can_edit":true,"owner":{"id":42758412,"first_name":"Göran","middle_initials":null,"last_name":"Samsioe","page_name":"GoranSamsioe","domain_name":"independent","created_at":"2016-02-06T02:51:22.678-08:00","display_name":"Göran Samsioe","url":"https://independent.academia.edu/GoranSamsioe"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660504"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/75660504/Medication_Use_of_European_Women_Seeking_Treatment_for_Ui_Findings_from_the_Pure_Observational_Study"><img alt="Research paper thumbnail of Medication Use of European Women Seeking Treatment for Ui: Findings from the Pure Observational Study" class="work-thumbnail" src="https://attachments.academia-assets.com/83341449/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/75660504/Medication_Use_of_European_Women_Seeking_Treatment_for_Ui_Findings_from_the_Pure_Observational_Study">Medication Use of European Women Seeking Treatment for Ui: Findings from the Pure Observational Study</a></div><div class="wp-workCard_item"><span>European Urology Supplements</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We performed a large cohort study to assess the prognostic relevance of grade, stage, focality, d...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We performed a large cohort study to assess the prognostic relevance of grade, stage, focality, dimension, KI67 immunostaining and p53 immunostaining to predict the overall, cause-specifi c and progression free survival of patients with superfi cial bladder cancer. MATERIAL & METHODS: Since 1990 data regarding KI67, p53 have been collected in all patients with a diagnosis of superfi cial (Ta-T1), intermediate or high risk (G2-G3, multifocal or more than 2 cm in diameter) bladder cancer. All the patients have been treated with at least one course of 6 intravesical instillations with BCG. All the surgical specimens from TURBT have been examined by a single pathology team. The main end points were: overall survival, cause specifi c survival and progression free survival. The Log Rank test was used to compare the survival curves in the univariate analysis and the Cox regression model to weight the prognostic factors in the multivariate analysis. RESULTS: 345 patients, median age 72 (31-93) years, median follow-up 34 (1-170) months. 322 patients had a intermediate or high risk superfi cial bladder cancer, 23 had an in-situ carcinoma. Median KI67 was 22.5% (1-80), median p53 was 6% (0-80). During the follow-up time 38 patients had a progression to muscle invasive disease. The univariate statistical analysis showed signifi cant difference in overall survival between G2 versus G3 tumours. In cause specifi c survival the differences were between Ta and CIS versus T1 tumours. In progression free survival we found signifi cant differences between G2 versus G3, Ta and CIS versus T1, KI67 < 17% versus KI67 > 17% and tumours smaller than 2 cm versus tumours bigger than 2 cm. No prognostic relevance was found for p53 and focality. The multivariate analysis confi rmed an independent prognostic value for grade on overall survival; for grade and stage on cause specifi c survival; for grade, stage and KI67 on progression free survival. CONCLUSIONS: We analysed a huge sample of patients with intermediate or high risk superfi cial bladder cancer followed for a long period and treated in a homogeneous way. We found independent and signifi cant prognostic value for stage, grade, KI67 status and dimension of tumours in predicting the risk of progression to muscle invasive disease. Stage and grade remain the only characteristics able to predict cause specifi c survival.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="229be1259e919d89a423b8afca1e08cc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83341449,"asset_id":75660504,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83341449/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660504"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660504"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660504; 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I. 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Changes in lipid- and lipoprotein metabolism induced by high doses of medroxyprogesterone acetate (MPA)" class="work-thumbnail" src="https://attachments.academia-assets.com/83341447/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/75660499/266_Changes_in_lipid_and_lipoprotein_metabolism_induced_by_high_doses_of_medroxyprogesterone_acetate_MPA_">266. Changes in lipid- and lipoprotein metabolism induced by high doses of medroxyprogesterone acetate (MPA)</a></div><div class="wp-workCard_item"><span>Journal of Steroid Biochemistry</span><span>, 1982</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="daefc9c28ff912ce9c0135d7ff29433a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83341447,"asset_id":75660499,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83341447/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660499"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660499"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660499; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660499]").text(description); $(".js-view-count[data-work-id=75660499]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660499; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660499']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "daefc9c28ff912ce9c0135d7ff29433a" } } $('.js-work-strip[data-work-id=75660499]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75660499,"title":"266. Changes in lipid- and lipoprotein metabolism induced by high doses of medroxyprogesterone acetate (MPA)","internal_url":"https://www.academia.edu/75660499/266_Changes_in_lipid_and_lipoprotein_metabolism_induced_by_high_doses_of_medroxyprogesterone_acetate_MPA_","owner_id":42758412,"coauthors_can_edit":true,"owner":{"id":42758412,"first_name":"Göran","middle_initials":null,"last_name":"Samsioe","page_name":"GoranSamsioe","domain_name":"independent","created_at":"2016-02-06T02:51:22.678-08:00","display_name":"Göran Samsioe","url":"https://independent.academia.edu/GoranSamsioe"},"attachments":[{"id":83341447,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/83341447/thumbnails/1.jpg","file_name":"0022-4731_2882_2990480-020220406-32623-jyps41.pdf","download_url":"https://www.academia.edu/attachments/83341447/download_file","bulk_download_file_name":"266_Changes_in_lipid_and_lipoprotein_met.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/83341447/0022-4731_2882_2990480-020220406-32623-jyps41-libre.pdf?1649280308=\u0026response-content-disposition=attachment%3B+filename%3D266_Changes_in_lipid_and_lipoprotein_met.pdf\u0026Expires=1739757514\u0026Signature=gCgHCh-yBc1OmCkE4IT7mb-Z2QTxVvQ39J9AQa1-zWSH1S-Tp6Oatoqzf-lfQP1C6V6lgRP8XZ9v6UHV1IssPs4~fBfJN6Ly16-eishVhG2JTopQeobVze0va1tqjNPLz98WG3kXgGzpcjjtn34vg0YTozzVQEKrhW6htcvn2HxD1JX6SrD~hdIFGuDRtjo-wm9WB0sL~Fn0JFc7262GqGb5AHt-PK4iEJoRBhBfDIWRRRqnZtzJbu3r0D5wMVN-USSusKYz37cJdmuUwW~01nqFL8UCiejrw7hteTNNdKUUe0BxRtfI~-oiRd67ROZZes-pfTsBdIcXl05G39siZg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660496"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/75660496/Could_quality_of_life_impact_the_prevalence_of_metabolic_syndrome_Results_from_a_population_based_study_of_Swedish_women_the_Womens_Health_in_the_Lund_Area_Study"><img alt="Research paper thumbnail of Could quality of life impact the prevalence of metabolic syndrome? Results from a population-based study of Swedish women: the Women's Health in the Lund Area Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/75660496/Could_quality_of_life_impact_the_prevalence_of_metabolic_syndrome_Results_from_a_population_based_study_of_Swedish_women_the_Womens_Health_in_the_Lund_Area_Study">Could quality of life impact the prevalence of metabolic syndrome? Results from a population-based study of Swedish women: the Women's Health in the Lund Area Study</a></div><div class="wp-workCard_item"><span>Metabolic syndrome and related disorders</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The metabolic syndrome is regarded as an important risk factor for diabetes mellitus and cardiova...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The metabolic syndrome is regarded as an important risk factor for diabetes mellitus and cardiovascular disease. Metabolic syndrome could be associated with impaired quality of life (QoL). The Women&#39;s Health in the Lund Area (WHILA) project covers 10,766 women born between December 2, 1935, and December 1, 1945, living in the Lund area, of Sweden by December 1, 1995. The primary objectives of this project were to survey perimenopausal women in this area and to evaluate their health status and lifestyles. We used the criteria for the metabolic syndrome, as defined by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III), which include three or more of five risk factors: central obesity, elevated serum triglycerides, low high-density lipoprotein cholesterol (HDL-C), and elevated blood pressure and fasting glucose. Analysis of most aspects of daily life and QoL according to the Gothenburg Quality of Life Instrument (GQL) was done. GQL refers to the W...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660496"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660496"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660496; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=75660496]").text(description); $(".js-view-count[data-work-id=75660496]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 75660496; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='75660496']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=75660496]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":75660496,"title":"Could quality of life impact the prevalence of metabolic syndrome? Results from a population-based study of Swedish women: the Women's Health in the Lund Area Study","internal_url":"https://www.academia.edu/75660496/Could_quality_of_life_impact_the_prevalence_of_metabolic_syndrome_Results_from_a_population_based_study_of_Swedish_women_the_Womens_Health_in_the_Lund_Area_Study","owner_id":42758412,"coauthors_can_edit":true,"owner":{"id":42758412,"first_name":"Göran","middle_initials":null,"last_name":"Samsioe","page_name":"GoranSamsioe","domain_name":"independent","created_at":"2016-02-06T02:51:22.678-08:00","display_name":"Göran Samsioe","url":"https://independent.academia.edu/GoranSamsioe"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="75660494"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/75660494/Characteristics_of_European_Women_Consulting_a_Physician_for_the_First_Time_Results_from_the_Pure_Study_on_Urinary_Incontinence"><img alt="Research paper thumbnail of Characteristics of European Women Consulting a Physician for the First Time: Results from the Pure Study on Urinary Incontinence" class="work-thumbnail" src="https://attachments.academia-assets.com/83341452/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/75660494/Characteristics_of_European_Women_Consulting_a_Physician_for_the_First_Time_Results_from_the_Pure_Study_on_Urinary_Incontinence">Characteristics of European Women Consulting a Physician for the First Time: Results from the Pure Study on Urinary Incontinence</a></div><div class="wp-workCard_item"><span>European Urology Supplements</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We performed a large cohort study to assess the prognostic relevance of grade, stage, focality, d...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We performed a large cohort study to assess the prognostic relevance of grade, stage, focality, dimension, KI67 immunostaining and p53 immunostaining to predict the overall, cause-specifi c and progression free survival of patients with superfi cial bladder cancer. MATERIAL & METHODS: Since 1990 data regarding KI67, p53 have been collected in all patients with a diagnosis of superfi cial (Ta-T1), intermediate or high risk (G2-G3, multifocal or more than 2 cm in diameter) bladder cancer. All the patients have been treated with at least one course of 6 intravesical instillations with BCG. All the surgical specimens from TURBT have been examined by a single pathology team. The main end points were: overall survival, cause specifi c survival and progression free survival. The Log Rank test was used to compare the survival curves in the univariate analysis and the Cox regression model to weight the prognostic factors in the multivariate analysis. RESULTS: 345 patients, median age 72 (31-93) years, median follow-up 34 (1-170) months. 322 patients had a intermediate or high risk superfi cial bladder cancer, 23 had an in-situ carcinoma. Median KI67 was 22.5% (1-80), median p53 was 6% (0-80). During the follow-up time 38 patients had a progression to muscle invasive disease. The univariate statistical analysis showed signifi cant difference in overall survival between G2 versus G3 tumours. In cause specifi c survival the differences were between Ta and CIS versus T1 tumours. In progression free survival we found signifi cant differences between G2 versus G3, Ta and CIS versus T1, KI67 < 17% versus KI67 > 17% and tumours smaller than 2 cm versus tumours bigger than 2 cm. No prognostic relevance was found for p53 and focality. The multivariate analysis confi rmed an independent prognostic value for grade on overall survival; for grade and stage on cause specifi c survival; for grade, stage and KI67 on progression free survival. CONCLUSIONS: We analysed a huge sample of patients with intermediate or high risk superfi cial bladder cancer followed for a long period and treated in a homogeneous way. We found independent and signifi cant prognostic value for stage, grade, KI67 status and dimension of tumours in predicting the risk of progression to muscle invasive disease. Stage and grade remain the only characteristics able to predict cause specifi c survival.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a9a8d29eb058b91b68b30a526ab4143d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":83341452,"asset_id":75660494,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/83341452/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="75660494"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="75660494"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 75660494; 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Rees, L. Keith (Eds.), The Year in Postmenopausal Health, 312 pp., 234 mm × 156 mm, Illustrations, Hardback, Price: £59.99/US $99.95, ISBN: 1-904392-27-X" class="work-thumbnail" src="https://attachments.academia-assets.com/83341462/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/75660493/M_Rees_L_Keith_Eds_The_Year_in_Postmenopausal_Health_312_pp_234_mm_156_mm_Illustrations_Hardback_Price_59_99_US_99_95_ISBN_1_904392_27_X">M. Rees, L. 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