A New Treatment Modality for Palliative Care Oncologists-Pro

<!DOCTYPE html> <html lang="ta"> <head> <title>A New Treatment Modality for Palliative Care Oncologists-Pro | 25460</title> <meta name="keywords" content="Jerome H Check , "/> <meta name="description" content="In the last 15 years, there has been several presentations at national and international cancer meetings and multiple publications showing marked palliativ..25460"/> <meta name="citation_publisher" content="அறிவியல்தொழில்நுட்பம்" /> <meta name="citation_journal_title" content="நர்சிங் & நோயாளி பராமரிப்பு இதழ்"> <meta name="citation_title" content="A New Treatment Modality for Palliative Care Oncologists-Progesterone Receptor Modulators for very Advanced Cancer"> <meta name="citation_author" content="Jerome H Check" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="9"> <meta name="citation_issue" content="1"> <meta name="citation_abstract" content="In the last 15 years, there has been several presentations at national and international cancer meetings and multiple publications showing marked palliative benefits with significant extension of life in patients with very advanced cancers especially those where the cancer is devoid of the classical nuclear progesterone receptor by treating the patients with the progesterone receptor antagonist/modulator mifepristone. The target appears to be the immunomodulatory protein known as the Progesterone Induced Blocking Factor (PIBF). This drug is very well tolerated and given as a simple daily oral pill. Unfortunately, oncologists seem to be reluctant to treat even end stage patients with cancer with an off-label drug. Thus, when the patient’s cancer has extensively metastasized, and there are no other treatment options, the patient is referred to hospice to relieve pain and suffering while the patient’s family and friends pray for a quick death. This perspective/ commentary will show that the use of mifepristone, and possibly even better progesterone receptor modulators that could be developed, is the proper next step before preparing for death so that the patient can still look forward to a functional extension of life without suffering. The hope lies in the palliative care group to hopefully substantiate the efficacy of the drug and thus revolutionize the treatment of end-stage cancer. 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Palliative Care Oncologists-Progesterone Receptor Modulators for very Advanced Cancer</h2> <p><i class="fas fa-user"></i> Jerome H Check </p> <p><p>In the last 15 years, there has been several presentations at national and international cancer meetings and multiple publications showing marked palliative benefits with significant extension of life in patients with very advanced cancers especially those where the cancer is devoid of the classical nuclear progesterone receptor by treating the patients with the progesterone receptor antagonist/modulator mifepristone. The target appears to be the immunomodulatory protein known as the Progesterone Induced Blocking Factor (PIBF). This drug is very well tolerated and given as a simple daily oral pill. Unfortunately, oncologists seem to be reluctant to treat even end stage patients with cancer with an off-label drug. Thus, when the patient’s cancer has extensively metastasized, and there are no other treatment options, the patient is referred to hospice to relieve pain and suffering while the patient’s family and friends pray for a quick death. This perspective/ commentary will show that the use of mifepristone, and possibly even better progesterone receptor modulators that could be developed, is the proper next step before preparing for death so that the patient can still look forward to a functional extension of life without suffering. The hope lies in the palliative care group to hopefully substantiate the efficacy of the drug and thus revolutionize the treatment of end-stage cancer.</p> </p> <div class="alert alert-info text-left"><b>மறுப்பு:</b> இந்த சுருக்கமானது செயற்கை நுண்ணறிவு கருவிகளைப் பயன்படுத்தி மொழிபெயர்க்கப்பட்டது மற்றும் இன்னும் மதிப்பாய்வு செய்யப்படவில்லை அல்லது சரிபார்க்கப்படவில்லை</div> </div> </div>  <div class="col-xs-12 col-md-3"> <div class="divider-v4 divider-v4-left-double bg-color-white padding-10 margin-b-10"> <h2 class="divider-v4-title">SciTechnol ஐ ஆராயுங்கள்</h2> <div> <ul class="list-unstyled angle-right"> <li class="color-base"><a href="https://tamil.scitechnol.com/author-guidelines.html" title="இங்கே கிளிக் செய்யவும்"> ஆசிரியர் வழிகாட்டுதல்கள்</a></li> <li class="color-base"><a href="https://tamil.scitechnol.com/reviewer-guidelines.html" title="இங்கே கிளிக் செய்யவும்"> மதிப்பாய்வாளர் வழிகாட்டுதல்கள்</a></li> <li class="color-base"><a 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