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</div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r1268415487">.mw-parser-output .ib-chembox{border-collapse:collapse;text-align:left}.mw-parser-output .ib-chembox td,.mw-parser-output .ib-chembox th{border:1px solid #a2a9b1;width:40%}.mw-parser-output .ib-chembox td+td{width:60%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .ib-chembox figure:not(.skin-invert-image):not(.skin-invert):not(.bg-transparent){background:var(--background-color-inverted,#f8f9fa)}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .ib-chembox figure:not(.skin-invert-image):not(.skin-invert):not(.bg-transparent){background:var(--background-color-inverted,#f8f9fa)}}</style> <table class="infobox ib-chembox"> <caption>Met-enkephalin </caption> <tbody><tr> <td colspan="2" style="text-align:center; padding:2px;"><figure class="mw-halign-center skin-invert-image" typeof="mw:File"><a href="/wiki/File:Met-enkephalin_Structure.svg" class="mw-file-description" title="Skeletal formula of Met-enkphalin"><img alt="Skeletal formula of Met-enkphalin" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/ca/Met-enkephalin_Structure.svg/250px-Met-enkephalin_Structure.svg.png" decoding="async" width="250" height="72" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/ca/Met-enkephalin_Structure.svg/375px-Met-enkephalin_Structure.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/ca/Met-enkephalin_Structure.svg/500px-Met-enkephalin_Structure.svg.png 2x" data-file-width="512" data-file-height="148" /></a><figcaption>Skeletal formula of Met-enkphalin</figcaption></figure> </td></tr> <tr> <td colspan="2" style="text-align:center; padding:2px;"><figure class="mw-halign-center bg-transparent" typeof="mw:File"><a href="/wiki/File:Met-enkephalin_ball-and-stick.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f5/Met-enkephalin_ball-and-stick.png/250px-Met-enkephalin_ball-and-stick.png" decoding="async" width="250" height="93" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f5/Met-enkephalin_ball-and-stick.png/375px-Met-enkephalin_ball-and-stick.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f5/Met-enkephalin_ball-and-stick.png/500px-Met-enkephalin_ball-and-stick.png 2x" data-file-width="3000" data-file-height="1114" /></a><figcaption></figcaption></figure> </td></tr> <tr> <th colspan="2" style="background: #f8eaba;color:inherit; text-align: center;">Names </th></tr> <tr> <td colspan="2" style="text-align:left;"><a href="/wiki/Chemical_nomenclature" title="Chemical nomenclature">IUPAC name</a> <div style="max-width:22em; word-wrap:break-word; padding-left:1.7em;">(2<i>S</i>)-2-[[(2<i>S</i>)-2-[[2-[[2-[[(2<i>S</i>)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid</div> </td></tr> <tr> <td colspan="2" style="text-align:left;">Other names <div style="max-width:22em; word-wrap:break-word; padding-left:1.7em;">[Met]enkephalin; [Met<sup>5</sup>]enkephalin; <small>L</small>-Tyrosylglycylglycyl-<small>L</small>-phenylalanyl-<small>L</small>-methionine</div> </td></tr> <tr> <th colspan="2" style="background: #f8eaba;color:inherit; text-align: center;">Identifiers </th></tr> <tr> <td><div style="display: inline-block; line-height: 1.2em; padding: .1em 0;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></div> </td> <td><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=58569-55-4">58569-55-4</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div> </td></tr> <tr> <td><div style="display: inline-block; line-height: 1.2em; padding: .1em 0;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</div> </td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=CSCCC%28NC%28%3DO%29C%28Cc1ccccc1%29NC%28%3DO%29CNC%28%3DO%29CNC%28%3DO%29C%28N%29Cc1ccc%28O%29cc1%29C%28O%29%3DO">Interactive image</a></span></li><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=CSCCC%28NC%28%3DO%29C%28CC1%3DCC%3DCC%3DC1%29NC%28%3DO%29CNC%28%3DO%29CNC%28%3DO%29C%28N%29CC1%3DCC%3DC%28O%29C%3DC1%29C%28O%29%3DO">Interactive image</a></span></li></ul></div> </td></tr> <tr> <td><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a> </td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=6618">CHEBI:6618</a></span></li></ul></div> </td></tr> <tr> <td><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a> </td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL13786">ChEMBL13786</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div> </td></tr> <tr> <td><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a> </td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.391597.html">391597</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div> </td></tr> <tr> <td><a href="/wiki/ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard"><span title="echa.europa.eu">ECHA InfoCard</span></a> </td> <td><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.055.741">100.055.741</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q1960495#P2566" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span> </td></tr> <tr> <td><a href="/wiki/European_Community_number" title="European Community number"><span title="European Community number (chemical identifier)">EC Number</span></a> </td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li>261-335-8</li></ul></div> </td></tr> <tr> <td><div style="display: inline-block; line-height: 1.2em; padding: .1em 0;"><a href="/wiki/IUPHAR/BPS" class="mw-redirect" title="IUPHAR/BPS">IUPHAR/BPS</a></div> </td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="www.guidetopharmacology.org"><a rel="nofollow" class="external text" href="http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=summary&ligandId=1614">1614</a></span></li></ul></div> </td></tr> <tr> <td><a href="/wiki/KEGG" title="KEGG">KEGG</a> </td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/C11684">C11684</a></span><sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></li></ul></div> </td></tr> <tr> <td><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a> </td> <td><span title="www.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?mode=&term=Enkephalin,+Methionine">Enkephalin,+Methionine</a></span> </td></tr> <tr> <td><div style="display: inline-block; line-height: 1.2em; padding: .1em 0;"><a href="/wiki/PubChem" title="PubChem">PubChem</a> <abbr title="Compound ID">CID</abbr></div> </td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/443363">443363</a></span></li></ul></div> </td></tr> <tr> <td><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a> </td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/9JEZ9OD3AS">9JEZ9OD3AS</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div> </td></tr> <tr> <td><div style="display: inline-block; line-height: 1.2em; padding: .1em 0;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></div> </td> <td><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID80332078">DTXSID80332078</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q1960495#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div> </td></tr> <tr> <td colspan="2"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold; text-align:left; font-weight:normal;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="border-top:1px solid #ccc; padding:0.2em 0 0.2em 1.5em; text-align:left;"><div style="word-wrap:break-word; text-indent:-1.5em; font-size:97%; line-height:120%;">InChI=1S/C27H35N5O7S/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18/h2-10,20-22,33H,11-16,28H2,1H3,(H,29,34)(H,30,36)(H,31,35)(H,32,37)(H,38,39)<sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></div><div style="word-wrap:break-word; text-indent:-1.5em; font-size:97%; line-height:120%;">Key: YFGBQHOOROIVKG-UHFFFAOYSA-N<sup> <span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup></div></div></li></ul> </div> </td></tr> <tr> <td colspan="2"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold; text-align:left; font-weight:normal;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="border-top:1px solid #ccc; padding:0.2em 0 0.2em 1.6em; word-wrap:break-word; text-indent:-1.5em; text-align:left; font-size:97%; line-height:120%;">CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(O)=O</div></li><li style="line-height: inherit; margin: 0"><div style="border-top:1px solid #ccc; padding:0.2em 0 0.2em 1.6em; word-wrap:break-word; text-indent:-1.5em; text-align:left; font-size:97%; line-height:120%;">CSCCC(NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(N)CC1=CC=C(O)C=C1)C(O)=O</div></li></ul> </div> </td></tr> <tr> <th colspan="2" style="background: #f8eaba;color:inherit; text-align: center;">Properties </th></tr> <tr> <td><div style="display: inline-block; line-height: 1.2em; padding: .1em 0;"><a href="/wiki/Chemical_formula" title="Chemical formula">Chemical formula</a></div> </td> <td><span title="Carbon">C</span><sub>27</sub><span title="Hydrogen">H</span><sub>35</sub><span title="Nitrogen">N</span><sub>5</sub><span title="Oxygen">O</span><sub>7</sub><span title="Sulfur">S</span> </td></tr> <tr> <td><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a> </td> <td><span class="nowrap"><span data-sort-value="7002573670000000000♠"></span>573.67</span> g·mol<sup>−1</sup>   </td></tr> <tr> <td><a href="/wiki/Partition_coefficient" title="Partition coefficient">log <i>P</i></a> </td> <td>0.607 </td></tr> <tr> <td><a href="/wiki/Acid_dissociation_constant" title="Acid dissociation constant">Acidity</a> (p<i>K</i><sub>a</sub>) </td> <td>3.234 </td></tr> <tr> <td><a href="/wiki/Acid_dissociation_constant" title="Acid dissociation constant">Basicity</a> (p<i>K</i><sub>b</sub>) </td> <td>10.763 </td></tr> <tr> <td colspan="2" style="text-align:left; background:#f8eaba; color:inherit; border:1px solid #a2a9b1;"><div style="display: inline-block; line-height: 1.2em; padding: .1em 0;">Except where otherwise noted, data are given for materials in their <a href="/wiki/Standard_state" title="Standard state">standard state</a> (at 25 °C [77 °F], 100 kPa).</div> <div style="margin-top: 0.3em;"><div style="text-align:center;"><span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/12px-X_mark.svg.png" decoding="async" width="12" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/18px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/24px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span> <span class="reflink plainlinks nourlexpansion"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=458949133&page2=Met-enkephalin">verify</a></span> (<a href="/wiki/Wikipedia:WikiProject_Chemicals/Chembox_validation" title="Wikipedia:WikiProject Chemicals/Chembox validation">what is</a> <sup><span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span><span typeof="mw:File"><span><img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" /></span></span><span style="display:none">N</span></sup> ?) </div></div> <div style="margin-top: 0.3em; text-align: center;"><a href="/wiki/Wikipedia:Chemical_infobox#References" title="Wikipedia:Chemical infobox">Infobox references</a></div> </td></tr> </tbody></table><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Chemical compound</div> <p><b>Met-enkephalin</b>, also known as <b>metenkefalin</b> (<a href="/wiki/International_Nonproprietary_Name" class="mw-redirect" title="International Nonproprietary Name">INN</a>), sometimes referred to as <b>opioid growth factor</b> (<b>OGF</b>),<sup id="cite_ref-pmid8164525_1-0" class="reference"><a href="#cite_note-pmid8164525-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> is a <a href="/wiki/Natural_product" title="Natural product">naturally occurring</a>, <a href="/wiki/Endogenous" class="mw-redirect" title="Endogenous">endogenous</a> <a href="/wiki/Opioid_peptide" title="Opioid peptide">opioid peptide</a> that has <a href="/wiki/Opioid" title="Opioid">opioid</a> effects of a relatively short duration. It is one of the two forms of <a href="/wiki/Enkephalin" title="Enkephalin">enkephalin</a>, the other being <a href="/wiki/Leu-enkephalin" title="Leu-enkephalin">leu-enkephalin</a>. The enkephalins are considered to be the primary endogenous ligands of the <a href="/wiki/Delta-opioid_receptor" class="mw-redirect" title="Delta-opioid receptor">δ-opioid receptor</a>, due to their high <a href="/wiki/Potency_(pharmacology)" title="Potency (pharmacology)">potency</a> and <a href="/wiki/Binding_selectivity" title="Binding selectivity">selectivity</a> for the site over the other <a href="/wiki/Endogenous_opioid" class="mw-redirect" title="Endogenous opioid">endogenous opioids</a>.<sup id="cite_ref-Stein1999_2-0" class="reference"><a href="#cite_note-Stein1999-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Met-enkephalin&action=edit&section=1" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Met-enkephalin was discovered and characterized by <a href="/wiki/John_Hughes_(neuroscientist)" title="John Hughes (neuroscientist)">John Hughes</a>, <a href="/wiki/Hans_Kosterlitz" title="Hans Kosterlitz">Hans Kosterlitz</a>, <i>et al</i>. in 1975 after a search for endogenous ligands of the opioid receptors.<sup id="cite_ref-Moore1993_3-0" class="reference"><a href="#cite_note-Moore1993-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Chemistry">Chemistry</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Met-enkephalin&action=edit&section=2" title="Edit section: Chemistry"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Met-enkephalin is a <a href="/wiki/Pentapeptide_(oligopeptide)" class="mw-redirect" title="Pentapeptide (oligopeptide)">pentapeptide</a> with the <a href="/wiki/Amino_acid_sequence" class="mw-redirect" title="Amino acid sequence">amino acid sequence</a> tyr-gly-gly-phe-met. The <a href="/wiki/Tyrosine" title="Tyrosine">tyrosine</a> <a href="/wiki/Residue_(chemistry)" title="Residue (chemistry)">residue</a> at position 1 is thought to be <a href="/wiki/Structural_analog" title="Structural analog">analogous</a> to the 3-<a href="/wiki/Hydroxyl" class="mw-redirect" title="Hydroxyl">hydroxyl</a> <a href="/wiki/Functional_group" title="Functional group">group</a> on <a href="/wiki/Morphine" title="Morphine">morphine</a>.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (November 2011)">citation needed</span></a></i>]</sup> </p> <div class="mw-heading mw-heading2"><h2 id="Biochemistry">Biochemistry</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Met-enkephalin&action=edit&section=3" title="Edit section: Biochemistry"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Distribution">Distribution</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Met-enkephalin&action=edit&section=4" title="Edit section: Distribution"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Met-enkephalin is found mainly in the <a href="/wiki/Adrenal_medulla" title="Adrenal medulla">adrenal medulla</a> and throughout the <a href="/wiki/Central_nervous_system" title="Central nervous system">central nervous system</a> (CNS), including in the <a href="/wiki/Striatum" title="Striatum">striatum</a>, <a href="/wiki/Cerebral_cortex" title="Cerebral cortex">cerebral cortex</a>, <a href="/wiki/Olfactory_tubercle" title="Olfactory tubercle">olfactory tubercle</a>, <a href="/wiki/Hippocampus" title="Hippocampus">hippocampus</a>, <a href="/wiki/Septum" title="Septum">septum</a>, <a href="/wiki/Thalamus" title="Thalamus">thalamus</a>, and <a href="/wiki/Periaqueductal_gray" title="Periaqueductal gray">periaqueductal gray</a>, as well as the <a href="/wiki/Posterior_horn_of_spinal_cord" class="mw-redirect" title="Posterior horn of spinal cord">dorsal horn</a> of the <a href="/wiki/Spinal_cord" title="Spinal cord">spinal cord</a>.<sup id="cite_ref-Stein1999_2-1" class="reference"><a href="#cite_note-Stein1999-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> It is also present in the periphery, notably in some <a href="/wiki/Type_Ia_sensory_fiber" title="Type Ia sensory fiber">primary afferent fibers</a> that <a href="/wiki/Innervate" class="mw-redirect" title="Innervate">innervate</a> the <a href="/wiki/Pelvic_viscera" class="mw-redirect" title="Pelvic viscera">pelvic viscera</a>.<sup id="cite_ref-Stein1999_2-2" class="reference"><a href="#cite_note-Stein1999-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Biosynthesis">Biosynthesis</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Met-enkephalin&action=edit&section=5" title="Edit section: Biosynthesis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Met-enkephalin is <a href="/wiki/Synthesis_(chemistry)" class="mw-redirect" title="Synthesis (chemistry)">synthesized</a> from <a href="/wiki/Proenkephalin" title="Proenkephalin">proenkephalin</a> via <a href="/wiki/Proteolysis" title="Proteolysis">proteolytic</a> <a href="/wiki/Bond_cleavage" title="Bond cleavage">cleavage</a><sup id="cite_ref-Strand1999_4-0" class="reference"><a href="#cite_note-Strand1999-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> in two <a href="/wiki/Metabolism" title="Metabolism">metabolic</a> steps. Proenkephalin A is first reduced by either one of two <a href="/wiki/Trypsin" title="Trypsin">trypsin</a>-like <a href="/wiki/Endopeptidase" title="Endopeptidase">endopeptidase</a> <a href="/wiki/Enzyme" title="Enzyme">enzymes</a>, <a href="/wiki/Prohormone_convertase_1" class="mw-redirect" title="Prohormone convertase 1">prohormone convertase 1</a> (PC1) or <a href="/wiki/Prohormone_convertase_2" class="mw-redirect" title="Prohormone convertase 2">prohormone convertase 2</a> (PC2); then, the resulting <a href="/wiki/Reaction_intermediate" title="Reaction intermediate">intermediates</a> are further reduced by the enzyme <a href="/wiki/Carboxypeptidase_E" title="Carboxypeptidase E">carboxypeptidase E</a> (CPE; previously known as enkephalin convertase (EC)).<sup id="cite_ref-pmid3111927_5-0" class="reference"><a href="#cite_note-pmid3111927-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid20040394_6-0" class="reference"><a href="#cite_note-pmid20040394-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Proenkephalin A contains four sequences of met-enkephalin (at the following positions: 100–104; 107–111; 136–140; 210–214), and as a result, its cleavage generates four copies of met-enkephalin peptides at once.<sup id="cite_ref-Strand1999_4-1" class="reference"><a href="#cite_note-Strand1999-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> In addition, anabolism of proenkephalin A results in the production of one copy each of two <a href="/wiki/C-terminus" title="C-terminus">C-terminal</a>-extended met-enkephalin <a href="/wiki/Derivative_(chemistry)" title="Derivative (chemistry)">derivatives</a>, the <a href="/wiki/Heptapeptide" class="mw-redirect" title="Heptapeptide">heptapeptide</a> met-enkephalin-arg-phe (261–267), and the <a href="/wiki/Octapeptide" class="mw-redirect" title="Octapeptide">octapeptide</a> met-enkephalin-arg-gly-leu (186–193),<sup id="cite_ref-Strand1999_4-2" class="reference"><a href="#cite_note-Strand1999-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> though whether they affect the opioid receptors in a similar manner as met-enkephalin is not entirely clear.<sup id="cite_ref-pmid19716174_7-0" class="reference"><a href="#cite_note-pmid19716174-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Clearance">Clearance</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Met-enkephalin&action=edit&section=6" title="Edit section: Clearance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Met- and leu-enkephalin are metabolized by a variety of different enzymes, including <a href="/wiki/Aminopeptidase_N" class="mw-redirect" title="Aminopeptidase N">aminopeptidase N</a> (APN),<sup id="cite_ref-pmid18855623_8-0" class="reference"><a href="#cite_note-pmid18855623-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Neutral_endopeptidase" class="mw-redirect" title="Neutral endopeptidase">neutral endopeptidase</a> (NEP),<sup id="cite_ref-pmid18855623_8-1" class="reference"><a href="#cite_note-pmid18855623-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Dipeptidyl_peptidase_3" class="mw-redirect" title="Dipeptidyl peptidase 3">dipeptidyl peptidase 3</a> (DPP3),<sup id="cite_ref-pmid18855623_8-2" class="reference"><a href="#cite_note-pmid18855623-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Carboxypeptidase_A6" title="Carboxypeptidase A6">carboxypeptidase A6</a> (CPA6),<sup id="cite_ref-pmid18178555_9-0" class="reference"><a href="#cite_note-pmid18178555-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> and <a href="/wiki/Angiotensin-converting_enzyme" title="Angiotensin-converting enzyme">angiotensin-converting enzyme</a> (ACE).<sup id="cite_ref-pmid20487892_10-0" class="reference"><a href="#cite_note-pmid20487892-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> These enzymes are sometimes referred to as <a href="/wiki/Enkephalinase" title="Enkephalinase">enkephalinases</a>. </p> <div class="mw-heading mw-heading3"><h3 id="Biological_activity">Biological activity</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Met-enkephalin&action=edit&section=7" title="Edit section: Biological activity"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Met-enkephalin is a <a href="/wiki/Potency_(pharmacology)" title="Potency (pharmacology)">potent</a> <a href="/wiki/Agonist" title="Agonist">agonist</a> of the <a href="/wiki/Delta-opioid_receptor" class="mw-redirect" title="Delta-opioid receptor">δ-opioid receptor</a>, and to a lesser extent the <a href="/wiki/Mu-opioid_receptor" class="mw-redirect" title="Mu-opioid receptor">μ-opioid receptor</a>, with little to no effect on the <a href="/wiki/Kappa-opioid_receptor" class="mw-redirect" title="Kappa-opioid receptor">κ-opioid receptor</a>. It is through these receptors that met-enkephalin produces its opioid effects, such as <a href="/wiki/Analgesia" class="mw-redirect" title="Analgesia">analgesia</a> and <a href="/wiki/Antidepressant" title="Antidepressant">antidepressant</a>-like effects. </p><p>It is also the endogenous <a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligand</a> of the <a href="/wiki/Opioid_growth_factor_receptor" class="mw-redirect" title="Opioid growth factor receptor">opioid growth factor receptor</a> (OGFR; formerly known as the ζ-opioid receptor), which plays a role in the regulation of tissue growth and regeneration; hence why met-enkephalin is sometimes called OGF instead. </p> <div class="mw-heading mw-heading3"><h3 id="Pharmacokinetics">Pharmacokinetics</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Met-enkephalin&action=edit&section=8" title="Edit section: Pharmacokinetics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Met-enkephalin has low <a href="/wiki/Bioavailability" title="Bioavailability">bioavailability</a>, is rapidly <a href="/wiki/Metabolized" class="mw-redirect" title="Metabolized">metabolized</a>, and has a very short <a href="/wiki/Half-life" title="Half-life">half-life</a> (minutes).<sup id="cite_ref-Moore1993_3-1" class="reference"><a href="#cite_note-Moore1993-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-KraemerRogol2005_11-0" class="reference"><a href="#cite_note-KraemerRogol2005-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> These properties are considered undesirable in pharmaceuticals as large doses would need to be administered multiple times an hour to maintain a therapeutically relevant effect, making it unlikely that met-enkephalin will ever be used as a medicine. </p><p>[D-Ala2]-Met-enkephalinamide (DALA), is a synthetic enkephalin analog which is not susceptible to degradation by brain enzymes and at low doses (5 to 10 micrograms) caused profound, long-lasting, morphine-like analgesia when microinjected into a rat’s brain.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Met-enkephalin&action=edit&section=9" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Leu-enkephalin" title="Leu-enkephalin">Leu-enkephalin</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Met-enkephalin&action=edit&section=10" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 30em;"> <ol class="references"> <li id="cite_note-pmid8164525-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid8164525_1-0">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFZagonIsayamaMcLaughlin1994" class="citation journal cs1">Zagon IS, Isayama T, McLaughlin PJ (January 1994). "Preproenkephalin mRNA expression in the developing and adult rat brain". <i>Brain Research. Molecular Brain Research</i>. <b>21</b> (<span class="nowrap">1–</span>2): <span class="nowrap">85–</span>98. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0169-328x%2894%2990381-6">10.1016/0169-328x(94)90381-6</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8164525">8164525</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Brain+Research.+Molecular+Brain+Research&rft.atitle=Preproenkephalin+mRNA+expression+in+the+developing+and+adult+rat+brain&rft.volume=21&rft.issue=%3Cspan+class%3D%22nowrap%22%3E1%E2%80%93%3C%2Fspan%3E2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E85-%3C%2Fspan%3E98&rft.date=1994-01&rft_id=info%3Adoi%2F10.1016%2F0169-328x%2894%2990381-6&rft_id=info%3Apmid%2F8164525&rft.aulast=Zagon&rft.aufirst=IS&rft.au=Isayama%2C+T&rft.au=McLaughlin%2C+PJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMet-enkephalin" class="Z3988"></span></span> </li> <li id="cite_note-Stein1999-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-Stein1999_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Stein1999_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Stein1999_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFChristoph_Stein1999" class="citation book cs1">Christoph Stein (1999). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=4Rfr8cQayvgC&pg=PA22"><i>Opioids in pain control: basic and clinical aspects</i></a>. Cambridge University Press. pp. <span class="nowrap">22–</span>23. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-521-62269-1" title="Special:BookSources/978-0-521-62269-1"><bdi>978-0-521-62269-1</bdi></a><span class="reference-accessdate">. Retrieved <span class="nowrap">25 November</span> 2011</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Opioids+in+pain+control%3A+basic+and+clinical+aspects&rft.pages=%3Cspan+class%3D%22nowrap%22%3E22-%3C%2Fspan%3E23&rft.pub=Cambridge+University+Press&rft.date=1999&rft.isbn=978-0-521-62269-1&rft.au=Christoph+Stein&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3D4Rfr8cQayvgC%26pg%3DPA22&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMet-enkephalin" class="Z3988"></span></span> </li> <li id="cite_note-Moore1993-3"><span class="mw-cite-backlink">^ <a href="#cite_ref-Moore1993_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Moore1993_3-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFThomas_Carleton_Moore1993" class="citation book cs1">Thomas Carleton Moore (1993). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=dJyJGevjkzQC&pg=PA179"><i>Neurovascular immunology: vasoactive neurotransmitters and modulators in cellular immunity and memory</i></a>. CRC Press. p. 179. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-8493-6894-3" title="Special:BookSources/978-0-8493-6894-3"><bdi>978-0-8493-6894-3</bdi></a><span class="reference-accessdate">. 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href="/wiki/Template:Neuropeptides" title="Template:Neuropeptides"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Neuropeptides" title="Template talk:Neuropeptides"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Neuropeptides" title="Special:EditPage/Template:Neuropeptides"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Peptides:_neuropeptides82" style="font-size:114%;margin:0 4em"><a href="/wiki/Peptide" title="Peptide">Peptides</a>: <a href="/wiki/Neuropeptide" title="Neuropeptide">neuropeptides</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Hormones</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"><i>see <a href="/wiki/Template:Hormones" title="Template:Hormones">hormones</a></i></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Opioid_peptide" title="Opioid peptide">Opioid peptides</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12em"><a href="/wiki/Dynorphin" title="Dynorphin">Dynorphins</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dynorphin_A" title="Dynorphin A">Dynorphin A</a> <ul><li><a href="/wiki/Dynorphin_A1%E2%80%938" class="mw-redirect" title="Dynorphin A1–8">Dynorphin A<sub>1–8</sub></a></li></ul></li> <li><a href="/wiki/Dynorphin_B" title="Dynorphin B">Dynorphin B</a></li> <li><a href="/wiki/Big_dynorphin" title="Big dynorphin">Big dynorphin</a></li> <li><a href="/wiki/Leumorphin" title="Leumorphin">Leumorphin</a></li> <li><a href="/wiki/Alpha-Neoendorphin" class="mw-redirect" title="Alpha-Neoendorphin">α-Neoendorphin</a></li> <li><a href="/wiki/Beta-Neoendorphin" class="mw-redirect" title="Beta-Neoendorphin">β-Neoendorphin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:12em"><a href="/wiki/Endomorphin" title="Endomorphin">Endomorphins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Endomorphin-1" title="Endomorphin-1">Endomorphin-1</a></li> <li><a href="/wiki/Endomorphin-2" title="Endomorphin-2">Endomorphin-2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:12em"><a href="/wiki/Endorphins" title="Endorphins">Endorphins</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alpha-Endorphin" class="mw-redirect" title="Alpha-Endorphin">α-Endorphin</a></li> <li><a href="/wiki/Beta-Endorphin" class="mw-redirect" title="Beta-Endorphin">β-Endorphin</a></li> <li><a href="/wiki/Gamma-Endorphin" class="mw-redirect" title="Gamma-Endorphin">γ-Endorphin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:12em"><a href="/wiki/Enkephalin" title="Enkephalin">Enkephalins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Met-enkephalin</a></li> <li><a href="/wiki/Leu-enkephalin" title="Leu-enkephalin">Leu-enkephalin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:12em">Others</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adrenorphin" title="Adrenorphin">Adrenorphin</a></li> <li><a href="/wiki/Amidorphin" title="Amidorphin">Amidorphin</a></li> <li><a href="/wiki/Hemorphin" title="Hemorphin">Hemorphin</a> <ul><li><a href="/wiki/Hemorphin-4" title="Hemorphin-4">Hemorphin-4</a></li></ul></li> <li><a href="/wiki/Nociceptin" title="Nociceptin">Nociceptin</a></li> <li><a href="/wiki/Opiorphin" title="Opiorphin">Opiorphin</a></li> <li><a href="/wiki/Spinorphin" title="Spinorphin">Spinorphin</a></li> <li><a href="/wiki/Valorphin" title="Valorphin">Valorphin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other<br /> neuropeptides</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:12em"><a href="/wiki/Kinin" title="Kinin">Kinins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <dl><dd><a href="/wiki/Bradykinin" title="Bradykinin">Bradykinins</a></dd> <dd><a href="/wiki/Tachykinin_peptides" title="Tachykinin peptides">Tachykinins</a>: mammal <ul><li><a href="/wiki/Substance_P" title="Substance P">Substance P</a></li> <li><a href="/wiki/Neurokinin_A" title="Neurokinin A">Neurokinin A</a></li> <li><a href="/wiki/Neurokinin_B" title="Neurokinin B">Neurokinin B</a></li></ul></dd> <dd>amphibian <ul><li><a href="/wiki/Kassinin" title="Kassinin">Kassinin</a></li> <li><a href="/wiki/Physalaemin" title="Physalaemin">Physalaemin</a></li></ul></dd></dl> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:12em">Neuromedins</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Neuromedin_B" title="Neuromedin B">B</a></li> <li><a href="/wiki/Neuromedin_N" title="Neuromedin N">N</a></li> <li><a href="/wiki/Neuromedin_S" title="Neuromedin S">S</a></li> <li><a href="/wiki/Neuromedin_U" title="Neuromedin U">U</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:12em"><a href="/wiki/Orexin" title="Orexin">Orexins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Orexin-A" title="Orexin-A">A</a></li> <li><a href="/wiki/Orexin_B" class="mw-redirect" title="Orexin B">B</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:12em">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Angiotensin" title="Angiotensin">Angiotensin</a></li> <li><a href="/wiki/Bombesin" title="Bombesin">Bombesin</a></li> <li><a href="/wiki/Calcitonin_gene-related_peptide" title="Calcitonin gene-related peptide">Calcitonin gene-related peptide</a></li> <li><a href="/wiki/Carnosine" title="Carnosine">Carnosine</a></li> <li><a href="/wiki/Cocaine_and_amphetamine_regulated_transcript" title="Cocaine and amphetamine regulated transcript">Cocaine- and amphetamine-regulated transcript</a></li> <li><a href="/wiki/Delta-sleep-inducing_peptide" title="Delta-sleep-inducing peptide">Delta-sleep-inducing peptide</a></li> <li><a href="/wiki/FMRFamide" title="FMRFamide">FMRFamide</a></li> <li><a href="/wiki/Galanin" title="Galanin">Galanin</a></li> <li><a href="/wiki/Galanin-like_peptide" title="Galanin-like peptide">Galanin-like peptide</a></li> <li><a href="/wiki/Gastrin-releasing_peptide" title="Gastrin-releasing peptide">Gastrin-releasing peptide</a></li> <li><a href="/wiki/Ghrelin" title="Ghrelin">Ghrelin</a></li> <li><a href="/w/index.php?title=Neuropeptide_AF&action=edit&redlink=1" class="new" title="Neuropeptide AF (page does not exist)">Neuropeptide AF</a></li> <li><a href="/wiki/Neuropeptide_FF" title="Neuropeptide FF">Neuropeptide FF</a></li> <li><a href="/w/index.php?title=Neuropeptide_SF&action=edit&redlink=1" class="new" title="Neuropeptide SF (page does not exist)">Neuropeptide SF</a></li> <li><a href="/w/index.php?title=Neuropeptide_VF&action=edit&redlink=1" class="new" title="Neuropeptide VF (page does not exist)">Neuropeptide VF</a></li> <li><a href="/wiki/Neuropeptide_S" title="Neuropeptide S">Neuropeptide S</a></li> <li><a href="/wiki/Neuropeptide_Y" title="Neuropeptide Y">Neuropeptide Y</a></li> <li><a href="/wiki/Neurophysins" title="Neurophysins">Neurophysins</a></li> <li><a href="/wiki/Neurotensin" title="Neurotensin">Neurotensin</a></li> <li><a href="/wiki/Pancreatic_polypeptide" title="Pancreatic polypeptide">Pancreatic polypeptide</a></li> <li><a href="/wiki/Pituitary_adenylate_cyclase-activating_peptide" title="Pituitary adenylate cyclase-activating peptide">Pituitary adenylate cyclase-activating peptide</a></li> <li><a href="/wiki/RVD-Hp%CE%B1" title="RVD-Hpα">RVD-Hpα</a></li> <li><a href="/wiki/VGF" title="VGF">VGF</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Opioid_receptor_modulators225" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Opioid_receptor_modulators" title="Template:Opioid receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Opioid_receptor_modulators" title="Template talk:Opioid receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Opioid_receptor_modulators" title="Special:EditPage/Template:Opioid receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Opioid_receptor_modulators225" style="font-size:114%;margin:0 4em"><a href="/wiki/Opioid_receptor" title="Opioid receptor">Opioid receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/%CE%9C-opioid_receptor" title="Μ-opioid receptor">μ-opioid</a><br />(MOR)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Agonists(abridged;full_list)67" scope="row" class="navbox-group" style="width:1%">Agonists<br />(abridged;<br /><a href="/wiki/List_of_opioids" title="List of opioids">full list</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/3-HO-PCP" title="3-HO-PCP">3-HO-PCP</a></li> <li><a href="/w/index.php?title=7-Acetoxymitragynine&action=edit&redlink=1" class="new" title="7-Acetoxymitragynine (page does not exist)">7-Acetoxymitragynine</a></li> <li><a href="/wiki/7-Hydroxymitragynine" title="7-Hydroxymitragynine">7-Hydroxymitragynine</a></li> <li><a href="/w/index.php?title=%CE%A8-Akuammigine&action=edit&redlink=1" class="new" title="Ψ-Akuammigine (page does not exist)">ψ-Akuammigine</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">α-Chlornaltrexamine</a></li> <li><a href="/w/index.php?title=Alpha-Narcotine&action=edit&redlink=1" class="new" title="Alpha-Narcotine (page does not exist)">α-Narcotine</a></li> <li><a href="/wiki/Acetyldihydrocodeine" title="Acetyldihydrocodeine">Acetyldihydrocodeine</a></li> <li><a href="/wiki/Acetylfentanyl" title="Acetylfentanyl">Acetylfentanyl</a></li> <li><a href="/wiki/Acrylfentanyl" title="Acrylfentanyl">Acrylfentanyl</a></li> <li><a href="/wiki/Adrenorphin" title="Adrenorphin">Adrenorphin (metorphamide)</a></li> <li><a href="/wiki/AH-7921" title="AH-7921">AH-7921</a></li> <li><a href="/wiki/Akuammicine" title="Akuammicine">Akuammicine</a></li> <li><a href="/w/index.php?title=Akuammidine&action=edit&redlink=1" class="new" title="Akuammidine (page does not exist)">Akuammidine</a></li> <li><a href="/wiki/Alfentanil" title="Alfentanil">Alfentanil</a></li> <li><a href="/wiki/Anileridine" title="Anileridine">Anileridine</a></li> <li><a href="/wiki/Apparicine" title="Apparicine">Apparicine</a></li> <li><a href="/wiki/Beta-Endorphin" class="mw-redirect" title="Beta-Endorphin">β-Endorphin</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-12P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-12P (page does not exist)">BAM-12P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-18P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-18P (page does not exist)">BAM-18P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-22P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-22P (page does not exist)">BAM-22P</a></li> <li><a href="/wiki/Benzhydrocodone" title="Benzhydrocodone">Benzhydrocodone</a></li> <li><a href="/wiki/Benzylmorphine" title="Benzylmorphine">Benzylmorphine</a></li> <li><a href="/wiki/Bezitramide" title="Bezitramide">Bezitramide</a></li> <li><a href="/wiki/Biphalin" title="Biphalin">Biphalin</a></li> <li><a href="/w/index.php?title=BU08070&action=edit&redlink=1" class="new" title="BU08070 (page does not exist)">BU08070</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Butorphan" class="mw-redirect" title="Butorphan">Butorphan</a></li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/Butyrfentanyl" title="Butyrfentanyl">Butyrfentanyl</a></li> <li><a href="/wiki/BW373U86" title="BW373U86">BW373U86</a></li> <li><a href="/wiki/Carfentanil" title="Carfentanil">Carfentanil</a></li> <li><a href="/wiki/Casokefamide" title="Casokefamide">Casokefamide</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Chloroxymorphamine" title="Chloroxymorphamine">Chloroxymorphamine</a></li> <li><a href="/wiki/Codeine" title="Codeine">Codeine</a></li> <li><a href="/wiki/DADLE" title="DADLE">DADLE</a></li> <li><a href="/wiki/DAMGO" title="DAMGO">DAMGO (DAGO)</a></li> <li><a href="/wiki/Dermorphin" title="Dermorphin">Dermorphin</a></li> <li><a href="/wiki/Desmetramadol" title="Desmetramadol">Desmetramadol</a> (desmethyltramadol)</li> <li><a href="/wiki/Desomorphine" title="Desomorphine">Desomorphine</a></li> <li><a href="/wiki/Deumitragynine" class="mw-redirect" title="Deumitragynine">Deumitragynine</a></li> <li><a href="/wiki/Dextromoramide" title="Dextromoramide">Dextromoramide</a></li> <li><a href="/wiki/Dextropropoxyphene" title="Dextropropoxyphene">Dextropropoxyphene</a> (propoxyphene)</li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/wiki/Dimenoxadol" title="Dimenoxadol">Dimenoxadol</a></li> <li><a href="/wiki/Dimethylaminopivalophenone" title="Dimethylaminopivalophenone">Dimethylaminopivalophenone</a></li> <li><a href="/wiki/Eluxadoline" title="Eluxadoline">Eluxadoline</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine</a> (heroin)</li> <li><a href="/wiki/Dihydrocodeine" title="Dihydrocodeine">Dihydrocodeine</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/Dinalbuphine_sebacate" title="Dinalbuphine sebacate">Dinalbuphine sebacate</a></li> <li><a href="/wiki/Diphenoxylate" title="Diphenoxylate">Diphenoxylate</a></li> <li><a href="/wiki/Dipipanone" title="Dipipanone">Dipipanone</a></li> <li><a href="/wiki/Dynorphin_A" title="Dynorphin A">Dynorphin A</a></li> <li><a href="/wiki/Embutramide" title="Embutramide">Embutramide</a></li> <li><a href="/wiki/Endomorphin-1" title="Endomorphin-1">Endomorphin-1</a></li> <li><a href="/wiki/Endomorphin-2" title="Endomorphin-2">Endomorphin-2</a></li> <li><a href="/wiki/Eseroline" title="Eseroline">Eseroline</a></li> <li><a href="/wiki/Ethylmorphine" title="Ethylmorphine">Ethylmorphine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a></li> <li><a href="/wiki/Fluorophen" title="Fluorophen">Fluorophen</a></li> <li><a href="/wiki/Frakefamide" title="Frakefamide">Frakefamide</a></li> <li><a href="/wiki/Furanylfentanyl" title="Furanylfentanyl">Furanylfentanyl</a></li> <li><a href="/wiki/Hemorphin-4" title="Hemorphin-4">Hemorphin-4</a></li> <li><a href="/wiki/Herkinorin" title="Herkinorin">Herkinorin</a></li> <li><a href="/wiki/Hodgkinsine" title="Hodgkinsine">Hodgkinsine</a></li> <li><a href="/wiki/Hydrocodone" title="Hydrocodone">Hydrocodone</a></li> <li><a href="/wiki/Hydromorphinol" title="Hydromorphinol">Hydromorphinol</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/IBNtxA" title="IBNtxA">IBNtxA</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/Ketobemidone" title="Ketobemidone">Ketobemidone</a></li> <li><a href="/wiki/Mitragyna_speciosa" title="Mitragyna speciosa">Kratom</a></li> <li><a href="/wiki/Laudanosine" title="Laudanosine">Laudanosine</a></li> <li><a href="/wiki/Lefetamine" title="Lefetamine">Lefetamine</a></li> <li><a href="/wiki/Leu-enkephalin" title="Leu-enkephalin">Leu-enkephalin</a></li> <li><a href="/wiki/Levacetylmethadol" title="Levacetylmethadol">Levacetylmethadol</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/Loperamide" title="Loperamide">Loperamide</a></li> <li><a href="/wiki/Loxicodegol" class="mw-redirect" title="Loxicodegol">Loxicodegol</a></li> <li><a href="/wiki/LS-115509" title="LS-115509">LS-115509</a></li> <li><a href="/wiki/Matrine" title="Matrine">Matrine</a></li> <li><a href="/wiki/Meptazinol" title="Meptazinol">Meptazinol</a></li> <li><a class="mw-selflink selflink">Met-enkephalin</a> (metenkefalin)</li> <li><a href="/wiki/Methadone" title="Methadone">Methadone</a></li> <li><a href="/wiki/Metkefamide" title="Metkefamide">Metkefamide</a></li> <li><a href="/wiki/Metopon" title="Metopon">Metopon</a></li> <li><a href="/wiki/Mitragynine" title="Mitragynine">Mitragynine</a></li> <li><a href="/wiki/Mitragynine_pseudoindoxyl" title="Mitragynine pseudoindoxyl">Mitragynine pseudoindoxyl</a></li> <li><a href="/wiki/Morphiceptin" title="Morphiceptin">Morphiceptin</a></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a></li> <li><a href="/wiki/Nalbuphine" title="Nalbuphine">Nalbuphine</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">Naloxone benzoylhydrazone</a> (NalBzOH)</li> <li><a href="/wiki/Nalmexone" title="Nalmexone">Nalmexone</a></li> <li><a href="/wiki/Naltalimide" title="Naltalimide">Naltalimide</a></li> <li><a href="/w/index.php?title=Neopine&action=edit&redlink=1" class="new" title="Neopine (page does not exist)">Neopine</a></li> <li><a href="/wiki/NFEPP" title="NFEPP">NFEPP</a></li> <li><a href="/wiki/Nicocodeine" title="Nicocodeine">Nicocodeine</a></li> <li><a href="/wiki/Nicodicodine" title="Nicodicodine">Nicodicodine</a></li> <li><a href="/wiki/Nicomorphine" title="Nicomorphine">Nicomorphine</a></li> <li><a href="/wiki/Norketamine" title="Norketamine">Norketamine</a></li> <li><a href="/wiki/Nufenoxole" title="Nufenoxole">Nufenoxole</a></li> <li><a href="/wiki/Octreotide" title="Octreotide">Octreotide</a></li> <li><a href="/wiki/Oliceridine" title="Oliceridine">Oliceridine</a></li> <li><a href="/wiki/Oxycodegol" title="Oxycodegol">Oxycodegol</a></li> <li><a href="/wiki/Oxymorphone-3-methoxynaltrexonazine" title="Oxymorphone-3-methoxynaltrexonazine">Oxymorphone-3-methoxynaltrexonazine</a> (OM-3-MNZ)</li> <li><a href="/wiki/Oripavine" title="Oripavine">Oripavine</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a></li> <li><a href="/wiki/Oxymorphazone" title="Oxymorphazone">Oxymorphazone</a></li> <li><a href="/w/index.php?title=Oxymorphonazine&action=edit&redlink=1" class="new" title="Oxymorphonazine (page does not exist)">Oxymorphonazine</a></li> <li><a href="/wiki/Oxymorphone" title="Oxymorphone">Oxymorphone</a></li> <li><a href="/w/index.php?title=Oxymorphone_phenylhydrazone&action=edit&redlink=1" class="new" title="Oxymorphone phenylhydrazone (page does not exist)">Oxymorphone phenylhydrazone</a></li> <li><a href="/w/index.php?title=Oxymorphone_p-nitrophenylhydrazone&action=edit&redlink=1" class="new" title="Oxymorphone p-nitrophenylhydrazone (page does not exist)">OxyPNPH</a></li> <li><i><a href="/wiki/Papaver_somniferum" title="Papaver somniferum">Papaver somniferum</a></i> (<a href="/wiki/Opium" title="Opium">opium</a>)</li> <li><a href="/wiki/Pentazocine" title="Pentazocine">Pentazocine</a></li> <li><a href="/wiki/Pericine" title="Pericine">Pericine</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Phenazocine" title="Phenazocine">Phenazocine</a></li> <li><a href="/wiki/Phencyclidine" title="Phencyclidine">Phencyclidine</a></li> <li><a href="/wiki/Piminodine" title="Piminodine">Piminodine</a></li> <li><a href="/wiki/Piritramide" title="Piritramide">Piritramide</a></li> <li><a href="/w/index.php?title=PL-017&action=edit&redlink=1" class="new" title="PL-017 (page does not exist)">PL-017</a></li> <li><a href="/wiki/Prodine" title="Prodine">Prodine</a></li> <li><a href="/wiki/Propiram" title="Propiram">Propiram</a></li> <li><a href="/wiki/PZM21" title="PZM21">PZM21</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/Remifentanil" title="Remifentanil">Remifentanil</a></li> <li><a href="/wiki/Salsolinol" title="Salsolinol">Salsolinol</a></li> <li><a href="/wiki/SC-17599" title="SC-17599">SC-17599</a></li> <li><a href="/wiki/Sinomenine" title="Sinomenine">Sinomenine</a></li> <li><a href="/wiki/Sufentanil" title="Sufentanil">Sufentanil</a></li> <li><a href="/wiki/Tapentadol" title="Tapentadol">Tapentadol</a></li> <li><a href="/wiki/Tetrahydropapaveroline" title="Tetrahydropapaveroline">Tetrahydropapaveroline</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li> <li><a href="/wiki/Thebaine" title="Thebaine">Thebaine</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li> <li><a href="/wiki/Tianeptine" title="Tianeptine">Tianeptine</a></li> <li><a href="/wiki/Tilidine" title="Tilidine">Tilidine</a></li> <li><a href="/wiki/Tramadol" title="Tramadol">Tramadol</a></li> <li><a href="/wiki/Trimebutine" title="Trimebutine">Trimebutine</a></li> <li><a href="/wiki/TRIMU_5" title="TRIMU 5">TRIMU 5</a></li> <li><a href="/wiki/TRV734" title="TRV734">TRV734</a></li> <li><a href="/w/index.php?title=Tubotaiwine&action=edit&redlink=1" class="new" title="Tubotaiwine (page does not exist)">Tubotaiwine</a></li> <li><a href="/wiki/U-47700" title="U-47700">U-47700</a></li> <li><a href="/wiki/Valorphin" title="Valorphin">Valorphin</a></li> <li><a href="/wiki/Viminol" title="Viminol">Viminol</a></li> <li><a href="/wiki/Xorphanol" title="Xorphanol">Xorphanol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Picenadol" title="Picenadol">(3S,4S)-Picenadol</a></li> <li><a href="/wiki/Viminol" title="Viminol">2-(S)-N,N-(R)-Viminol</a></li> <li><a href="/w/index.php?title=3CS-nalmefene&action=edit&redlink=1" class="new" title="3CS-nalmefene (page does not exist)">3CS-nalmefene</a></li> <li><a href="/wiki/4-Caffeoyl-1,5-quinide" title="4-Caffeoyl-1,5-quinide">4-Caffeoyl-1,5-quinide</a></li> <li><a href="/wiki/4%E2%80%B2-Hydroxyflavanone" class="mw-redirect" title="4′-Hydroxyflavanone">4′-Hydroxyflavanone</a></li> <li><a href="/wiki/4%27,7-Dihydroxyflavone" title="4',7-Dihydroxyflavone">4',7-Dihydroxyflavone</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol" title="6β-Naltrexol">6β-Naltrexol</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol-d4" title="6β-Naltrexol-d4">6β-Naltrexol-d4</a></li> <li><a href="/wiki/18-Methoxycoronaridine" title="18-Methoxycoronaridine">18-MC</a></li> <li><a href="/wiki/Alpha-Gliadin" class="mw-redirect" title="Alpha-Gliadin">α-Gliadin</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Beta-Funaltrexamine" class="mw-redirect" title="Beta-Funaltrexamine">β-Funaltrexamine</a></li> <li><a href="/wiki/Akuammine" title="Akuammine">Akuammine</a></li> <li><a href="/wiki/Alvimopan" title="Alvimopan">Alvimopan</a></li> <li><a href="/wiki/AM-251_(drug)" title="AM-251 (drug)">AM-251</a></li> <li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/wiki/Axelopran" title="Axelopran">Axelopran</a></li> <li><a href="/wiki/Bevenopran" title="Bevenopran">Bevenopran</a></li> <li><a href="/wiki/Catechin" title="Catechin">Catechin</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">Catechin gallate</a></li> <li><a href="/wiki/Clocinnamox" title="Clocinnamox">Clocinnamox</a></li> <li>CTAP</li> <li><a href="/w/index.php?title=CTOP&action=edit&redlink=1" class="new" title="CTOP (page does not exist)">CTOP</a></li> <li><a href="/w/index.php?title=Cyclofoxy&action=edit&redlink=1" class="new" title="Cyclofoxy (page does not exist)">Cyclofoxy</a></li> <li><a href="/wiki/Cyprodime" title="Cyprodime">Cyprodime</a></li> <li><a href="/wiki/Diacetylnalorphine" title="Diacetylnalorphine">Diacetylnalorphine</a></li> <li><a href="/wiki/Diprenorphine" title="Diprenorphine">Diprenorphine</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a></li> <li><a href="/wiki/Gallocatechol" title="Gallocatechol">EGC</a></li> <li><a href="/wiki/Epicatechin" class="mw-redirect" title="Epicatechin">Epicatechin</a></li> <li><a href="/wiki/Eptazocine" title="Eptazocine">Eptazocine</a></li> <li><a href="/wiki/Gemazocine" title="Gemazocine">Gemazocine</a></li> <li><a href="/w/index.php?title=Ginsenoside_R&action=edit&redlink=1" class="new" title="Ginsenoside R (page does not exist)">Ginsenoside R</a></li> <li><a href="/wiki/Hyperoside" title="Hyperoside">Hyperoside</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/JDTic" title="JDTic">JDTic</a></li> <li><a href="/wiki/Levallorphan" title="Levallorphan">Levallorphan</a></li> <li><a href="/wiki/Lobeline" title="Lobeline">Lobeline</a></li> <li><a href="/wiki/LY-255582" title="LY-255582">LY-255582</a></li> <li><a href="/wiki/LY-2196044" class="mw-redirect" title="LY-2196044">LY-2196044</a></li> <li><a href="/wiki/Methocinnamox" title="Methocinnamox">Methocinnamox</a></li> <li><a href="/wiki/Methylnaltrexone" title="Methylnaltrexone">Methylnaltrexone</a></li> <li><a href="/w/index.php?title=Methylsamidorphan_chloride&action=edit&redlink=1" class="new" title="Methylsamidorphan chloride (page does not exist)">Methylsamidorphan chloride</a></li> <li><a href="/wiki/Naldemedine" title="Naldemedine">Naldemedine</a></li> <li><a href="/wiki/Nalmefene" title="Nalmefene">Nalmefene</a></li> <li><a href="/wiki/Nalodeine" title="Nalodeine">Nalodeine (N-allylnorcodeine)</a></li> <li><a href="/wiki/Nalorphine" title="Nalorphine">Nalorphine</a></li> <li><a href="/wiki/Nalorphine_dinicotinate" title="Nalorphine dinicotinate">Nalorphine dinicotinate</a></li> <li><a href="/wiki/Naloxazone" title="Naloxazone">Naloxazone</a></li> <li><a href="/wiki/Naloxegol" title="Naloxegol">Naloxegol</a></li> <li><a href="/wiki/Naloxol" title="Naloxol">Naloxol</a></li> <li><a href="/wiki/Naloxonazine" title="Naloxonazine">Naloxonazine</a></li> <li><a href="/wiki/Naloxone" title="Naloxone">Naloxone</a></li> <li><a href="/w/index.php?title=Naltrexazone&action=edit&redlink=1" class="new" title="Naltrexazone (page does not exist)">Naltrexazone</a></li> <li><a href="/w/index.php?title=Naltrexonazine&action=edit&redlink=1" class="new" title="Naltrexonazine (page does not exist)">Naltrexonazine</a></li> <li><a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a></li> <li><a href="/wiki/Naltrindole" title="Naltrindole">Naltrindole</a></li> <li><a href="/wiki/Naringenin" title="Naringenin">Naringenin</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Oxilorphan" title="Oxilorphan">Oxilorphan</a></li> <li><a href="/wiki/Pawhuskin_A" title="Pawhuskin A">Pawhuskin A</a></li> <li><a href="/wiki/Rimonabant" title="Rimonabant">Rimonabant</a></li> <li><a href="/wiki/Quadazocine" title="Quadazocine">Quadazocine</a></li> <li><a href="/wiki/Samidorphan" title="Samidorphan">Samidorphan</a></li> <li><a href="/wiki/Taxifolin" title="Taxifolin">Taxifolin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/%CE%94-opioid_receptor" title="Δ-opioid receptor">δ-opioid</a><br />(DOR)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=3CS-nalmefene&action=edit&redlink=1" class="new" title="3CS-nalmefene (page does not exist)">3CS-nalmefene</a></li> <li><a href="/wiki/6%27-Guanidinonaltrindole" title="6'-Guanidinonaltrindole">6'-GNTI</a></li> <li><a href="/wiki/7-Spiroindanyloxymorphone" title="7-Spiroindanyloxymorphone">7-SIOM</a></li> <li><a href="/wiki/ADL-5747" title="ADL-5747">ADL-5747 (PF-04856881)</a></li> <li><a href="/wiki/ADL-5859" title="ADL-5859">ADL-5859</a></li> <li><a href="/wiki/Alazocine" title="Alazocine">Alazocine (SKF-10047)</a></li> <li><a href="/wiki/Amoxapine" title="Amoxapine">Amoxapine</a></li> <li><a href="/wiki/ARM390" title="ARM390">AR-M100390 (ARM390)</a></li> <li><a href="/wiki/AZD2327" class="mw-redirect" title="AZD2327">AZD2327</a></li> <li><a href="/wiki/Beta-Endorphin" class="mw-redirect" title="Beta-Endorphin">β-Endorphin</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-18P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-18P (page does not exist)">BAM-18P</a></li> <li><a href="/wiki/Biphalin" title="Biphalin">Biphalin</a></li> <li><a href="/wiki/BU-48" title="BU-48">BU-48</a></li> <li><a href="/wiki/Butorphan" class="mw-redirect" title="Butorphan">Butorphan</a></li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/BW373U86" title="BW373U86">BW373U86</a></li> <li><a href="/wiki/Casokefamide" title="Casokefamide">Casokefamide</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Codeine" title="Codeine">Codeine</a></li> <li><a href="/wiki/Cyclazocine" title="Cyclazocine">Cyclazocine</a></li> <li><a href="/wiki/DADLE" title="DADLE">DADLE</a></li> <li><a href="/wiki/Deltorphin" title="Deltorphin">Deltorphin A</a></li> <li><a href="/wiki/Deltorphin_I" title="Deltorphin I">Deltorphin I</a></li> <li><a href="/w/index.php?title=Deltorphin_II&action=edit&redlink=1" class="new" title="Deltorphin II (page does not exist)">Deltorphin II</a></li> <li><a href="/wiki/Desmethylclozapine" title="Desmethylclozapine">Desmethylclozapine</a></li> <li><a href="/wiki/Desmetramadol" title="Desmetramadol">Desmetramadol (desmethyltramadol)</a></li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine (heroin)</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/DPDPE" title="DPDPE">DPDPE</a></li> <li><a href="/wiki/DPI-221" title="DPI-221">DPI-221</a></li> <li><a href="/wiki/DPI-3290" title="DPI-3290">DPI-3290</a></li> <li><a href="/w/index.php?title=(D-Ser2,_Leu5,_Thr6)-Enkephalin&action=edit&redlink=1" class="new" title="(D-Ser2, Leu5, Thr6)-Enkephalin (page does not exist)">DSLET</a></li> <li><a href="/wiki/Ethylketazocine" title="Ethylketazocine">Ethylketazocine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a></li> <li><a href="/w/index.php?title=Fentanyl_isothiocyanate&action=edit&redlink=1" class="new" title="Fentanyl isothiocyanate (page does not exist)">FIT</a></li> <li><a href="/wiki/Fluorophen" title="Fluorophen">Fluorophen</a></li> <li><a href="/wiki/Hemorphin-4" title="Hemorphin-4">Hemorphin-4</a></li> <li><a href="/wiki/Hydrocodone" title="Hydrocodone">Hydrocodone</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/Isomethadone" title="Isomethadone">Isomethadone</a></li> <li><a href="/wiki/JNJ-20788560" title="JNJ-20788560">JNJ-20788560</a></li> <li><a href="/wiki/KNT-127" title="KNT-127">KNT-127</a></li> <li><a href="/wiki/Mitragyna_speciosa" title="Mitragyna speciosa">Kratom</a></li> <li><a href="/wiki/Laudanosine" title="Laudanosine">Laudanosine</a></li> <li><a href="/wiki/Leu-enkephalin" title="Leu-enkephalin">Leu-enkephalin</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/Lofentanil" title="Lofentanil">Lofentanil</a></li> <li><a class="mw-selflink selflink">Met-enkephalin (metenkefalin)</a></li> <li><a href="/wiki/Metazocine" title="Metazocine">Metazocine</a></li> <li><a href="/wiki/Metkefamide" title="Metkefamide">Metkefamide</a></li> <li><a href="/wiki/Mitragynine" title="Mitragynine">Mitragynine</a></li> <li><a href="/wiki/Mitragynine_pseudoindoxyl" title="Mitragynine pseudoindoxyl">Mitragynine pseudoindoxyl</a></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a></li> <li><a href="/wiki/N-Phenethyl-14-ethoxymetopon" title="N-Phenethyl-14-ethoxymetopon">N-Phenethyl-14-ethoxymetopon</a></li> <li><a href="/wiki/Norbuprenorphine" title="Norbuprenorphine">Norbuprenorphine</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/wiki/Oripavine" title="Oripavine">Oripavine</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a></li> <li><a href="/wiki/Oxymorphone" title="Oxymorphone">Oxymorphone</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Proglumide" title="Proglumide">Proglumide</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/RWJ-394674" title="RWJ-394674">RWJ-394674</a></li> <li><a href="/wiki/Samidorphan" title="Samidorphan">Samidorphan</a></li> <li><a href="/w/index.php?title=SB-235863&action=edit&redlink=1" class="new" title="SB-235863 (page does not exist)">SB-235863</a></li> <li><a href="/wiki/SNC-80" title="SNC-80">SNC-80</a></li> <li><a href="/w/index.php?title=SNC-162&action=edit&redlink=1" class="new" title="SNC-162 (page does not exist)">SNC-162</a></li> <li><a href="/wiki/TAN-67" title="TAN-67">TAN-67 (SB-205,607)</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li> <li><a href="/wiki/Thebaine" title="Thebaine">Thebaine</a></li> <li><a href="/wiki/C-8813" title="C-8813">Thiobromadol (C-8813)</a></li> <li><a href="/wiki/Tonazocine" title="Tonazocine">Tonazocine</a></li> <li><a href="/wiki/Tramadol" title="Tramadol">Tramadol</a></li> <li><a href="/w/index.php?title=TRV250&action=edit&redlink=1" class="new" title="TRV250 (page does not exist)">TRV250</a></li> <li><a href="/wiki/Xorphanol" title="Xorphanol">Xorphanol</a></li> <li><a href="/wiki/Zenazocine" title="Zenazocine">Zenazocine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/4%27,7-Dihydroxyflavone" title="4',7-Dihydroxyflavone">4',7-Dihydroxyflavone</a></li> <li><a href="/w/index.php?title=Naltrindole-5%27-isothiocyanate&action=edit&redlink=1" class="new" title="Naltrindole-5'-isothiocyanate (page does not exist)">5'-NTII</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol" title="6β-Naltrexol">6β-Naltrexol</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol-d4" title="6β-Naltrexol-d4">6β-Naltrexol-d4</a></li> <li><a href="/w/index.php?title=Alpha-Santolol&action=edit&redlink=1" class="new" title="Alpha-Santolol (page does not exist)">α-Santolol</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/wiki/Axelopran" title="Axelopran">Axelopran</a></li> <li><a href="/wiki/Bevenopran" title="Bevenopran">Bevenopran</a></li> <li><a href="/w/index.php?title=7-Benzylidenenaltrexone&action=edit&redlink=1" class="new" title="7-Benzylidenenaltrexone (page does not exist)">BNTX</a></li> <li><a href="/wiki/Catechin" title="Catechin">Catechin</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">Catechin gallate</a></li> <li><a href="/wiki/Clocinnamox" title="Clocinnamox">Clocinnamox</a></li> <li><a href="/wiki/Diacetylnalorphine" title="Diacetylnalorphine">Diacetylnalorphine</a></li> <li><a href="/wiki/Diprenorphine" title="Diprenorphine">Diprenorphine</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a></li> <li><a href="/wiki/Gallocatechol" title="Gallocatechol">EGC</a></li> <li><a href="/wiki/Eluxadoline" title="Eluxadoline">Eluxadoline</a></li> <li><a href="/wiki/Epicatechin" class="mw-redirect" title="Epicatechin">Epicatechin</a></li> <li><a href="/w/index.php?title=ICI-154129&action=edit&redlink=1" class="new" title="ICI-154129 (page does not exist)">ICI-154129</a></li> <li><a href="/w/index.php?title=ICI-174864&action=edit&redlink=1" class="new" title="ICI-174864 (page does not exist)">ICI-174864</a></li> <li><a href="/wiki/LY-255582" title="LY-255582">LY-255582</a></li> <li><a href="/wiki/LY-2196044" class="mw-redirect" title="LY-2196044">LY-2196044</a></li> <li><a href="/wiki/Methylnaltrexone" title="Methylnaltrexone">Methylnaltrexone</a></li> <li><a href="/w/index.php?title=Methylnaltrindole&action=edit&redlink=1" class="new" title="Methylnaltrindole (page does not exist)">Methylnaltrindole</a></li> <li><a href="/w/index.php?title=N-Benzylnaltrindole&action=edit&redlink=1" class="new" title="N-Benzylnaltrindole (page does not exist)">N-Benzylnaltrindole</a></li> <li><a href="/wiki/Nalmefene" title="Nalmefene">Nalmefene</a></li> <li><a href="/wiki/Nalorphine" title="Nalorphine">Nalorphine</a></li> <li><a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a></li> <li><a href="/wiki/Naltriben" title="Naltriben">Naltriben</a></li> <li><a href="/wiki/Naltrindole" title="Naltrindole">Naltrindole</a></li> <li><a href="/wiki/Naloxone" title="Naloxone">Naloxone</a></li> <li><a href="/wiki/Naringenin" title="Naringenin">Naringenin</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Pawhuskin_A" title="Pawhuskin A">Pawhuskin A</a></li> <li><a href="/wiki/Quadazocine" title="Quadazocine">Quadazocine</a></li> <li><a href="/w/index.php?title=SDM25N&action=edit&redlink=1" class="new" title="SDM25N (page does not exist)">SDM25N</a></li> <li><a href="/wiki/SoRI-9409" title="SoRI-9409">SoRI-9409</a></li> <li><a href="/wiki/Taxifolin" title="Taxifolin">Taxifolin</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/%CE%9A-opioid_receptor" title="Κ-opioid receptor">κ-opioid</a><br />(KOR)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=3CS-nalmefene&action=edit&redlink=1" class="new" title="3CS-nalmefene (page does not exist)">3CS-nalmefene</a></li> <li><a href="/wiki/6%27-Guanidinonaltrindole" title="6'-Guanidinonaltrindole">6'-GNTI</a></li> <li><a href="/wiki/8-Carboxamidocyclazocine" title="8-Carboxamidocyclazocine">8-CAC</a></li> <li><a href="/wiki/18-Methoxycoronaridine" title="18-Methoxycoronaridine">18-MC</a></li> <li><a href="/wiki/14-Methoxymetopon" title="14-Methoxymetopon">14-Methoxymetopon</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Beta-Funaltrexamine" class="mw-redirect" title="Beta-Funaltrexamine">β-Funaltrexamine</a></li> <li><a href="/wiki/Adrenorphin" title="Adrenorphin">Adrenorphin (metorphamide)</a></li> <li><a href="/wiki/Akuammicine" title="Akuammicine">Akuammicine</a></li> <li><a href="/wiki/Alazocine" title="Alazocine">Alazocine (SKF-10047)</a></li> <li><a href="/wiki/Allomatrine" class="mw-redirect" title="Allomatrine">Allomatrine</a></li> <li><a href="/w/index.php?title=Apadoline&action=edit&redlink=1" class="new" title="Apadoline (page does not exist)">Apadoline</a></li> <li><a href="/wiki/Asimadoline" title="Asimadoline">Asimadoline</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-12P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-12P (page does not exist)">BAM-12P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-18P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-18P (page does not exist)">BAM-18P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-22P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-22P (page does not exist)">BAM-22P</a></li> <li><a href="/wiki/Big_dynorphin" title="Big dynorphin">Big dynorphin</a></li> <li><a href="/wiki/Bremazocine" title="Bremazocine">Bremazocine</a></li> <li><a href="/wiki/BRL-52537" title="BRL-52537">BRL-52537</a></li> <li><a href="/wiki/Butorphan" class="mw-redirect" title="Butorphan">Butorphan</a></li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/BW373U86" title="BW373U86">BW373U86</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Ciprefadol" title="Ciprefadol">Ciprefadol</a></li> <li><a href="/wiki/CR665" title="CR665">CR665</a></li> <li><a href="/wiki/Cyclazocine" title="Cyclazocine">Cyclazocine</a></li> <li><a href="/wiki/Cyclorphan" title="Cyclorphan">Cyclorphan</a></li> <li><a href="/wiki/Cyprenorphine" title="Cyprenorphine">Cyprenorphine</a></li> <li><a href="/wiki/Desmetramadol" title="Desmetramadol">Desmetramadol (desmethyltramadol)</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine (heroin)</a></li> <li><a href="/wiki/Diacetylnalorphine" title="Diacetylnalorphine">Diacetylnalorphine</a></li> <li><a href="/wiki/Difelikefalin" title="Difelikefalin">Difelikefalin</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/Dinalbuphine_sebacate" title="Dinalbuphine sebacate">Dinalbuphine sebacate</a></li> <li><a href="/wiki/Diprenorphine" title="Diprenorphine">Diprenorphine</a></li> <li><a href="/wiki/Dynorphin_A" title="Dynorphin A">Dynorphin A</a></li> <li><a href="/wiki/Dynorphin_B" title="Dynorphin B">Dynorphin B (rimorphin)</a></li> <li><a href="/wiki/Eluxadoline" title="Eluxadoline">Eluxadoline</a></li> <li><a href="/wiki/Enadoline" title="Enadoline">Enadoline</a></li> <li><a href="/wiki/Eptazocine" title="Eptazocine">Eptazocine</a></li> <li><a href="/w/index.php?title=Erinacine_E&action=edit&redlink=1" class="new" title="Erinacine E (page does not exist)">Erinacine E</a></li> <li><a href="/wiki/Ethylketazocine" title="Ethylketazocine">Ethylketazocine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Fedotozine" title="Fedotozine">Fedotozine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a></li> <li><a href="/wiki/Gemazocine" title="Gemazocine">Gemazocine</a></li> <li><a href="/wiki/GR-89696" title="GR-89696">GR-89696</a></li> <li><a href="/w/index.php?title=GR-103545&action=edit&redlink=1" class="new" title="GR-103545 (page does not exist)">GR-103545</a></li> <li><a href="/wiki/Hemorphin-4" title="Hemorphin-4">Hemorphin-4</a></li> <li><a href="/wiki/Herkinorin" title="Herkinorin">Herkinorin</a></li> <li><a href="/wiki/HS665" title="HS665">HS665</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/HZ-2" title="HZ-2">HZ-2</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/ICI-199,441" title="ICI-199,441">ICI-199,441</a></li> <li><a href="/wiki/ICI-204,448" title="ICI-204,448">ICI-204,448</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/Ketazocine" title="Ketazocine">Ketazocine</a></li> <li><a href="/wiki/Laudanosine" title="Laudanosine">Laudanosine</a></li> <li><a href="/wiki/Leumorphin" title="Leumorphin">Leumorphin (dynorphin B-29)</a></li> <li><a href="/wiki/Levallorphan" title="Levallorphan">Levallorphan</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/Lofentanil" title="Lofentanil">Lofentanil</a></li> <li><a href="/wiki/LPK-26" title="LPK-26">LPK-26</a></li> <li><a href="/wiki/Lufuradom" title="Lufuradom">Lufuradom</a></li> <li><a href="/wiki/Matrine" title="Matrine">Matrine</a></li> <li><a href="/w/index.php?title=MB-1C-OH&action=edit&redlink=1" class="new" title="MB-1C-OH (page does not exist)">MB-1C-OH</a></li> <li><a href="/wiki/Menthol" title="Menthol">Menthol</a></li> <li><a href="/wiki/Metazocine" title="Metazocine">Metazocine</a></li> <li><a href="/wiki/Metkefamide" title="Metkefamide">Metkefamide</a></li> <li><a href="/wiki/Mianserin" title="Mianserin">Mianserin</a></li> <li><a href="/wiki/Mirtazapine" title="Mirtazapine">Mirtazapine</a></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a></li> <li><a href="/wiki/Moxazocine" title="Moxazocine">Moxazocine</a></li> <li><a href="/w/index.php?title=MR-2034&action=edit&redlink=1" class="new" title="MR-2034 (page does not exist)">MR-2034</a></li> <li><a href="/w/index.php?title=N-MPPP&action=edit&redlink=1" class="new" title="N-MPPP (page does not exist)">N-MPPP</a></li> <li><a href="/wiki/Nalbuphine" title="Nalbuphine">Nalbuphine</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/wiki/Nalfurafine" title="Nalfurafine">Nalfurafine</a></li> <li><a href="/wiki/Nalmefene" title="Nalmefene">Nalmefene</a></li> <li><a href="/wiki/Nalodeine" title="Nalodeine">Nalodeine (N-allylnorcodeine)</a></li> <li><a href="/wiki/Nalorphine" title="Nalorphine">Nalorphine</a></li> <li><a href="/wiki/Naltriben" title="Naltriben">Naltriben</a></li> <li><a href="/wiki/Niravoline" title="Niravoline">Niravoline</a></li> <li><a href="/wiki/Norbuprenorphine" title="Norbuprenorphine">Norbuprenorphine</a></li> <li><a href="/wiki/Norbuprenorphine-3-glucuronide" title="Norbuprenorphine-3-glucuronide">Norbuprenorphine-3-glucuronide</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Norketamine" title="Norketamine">Norketamine</a></li> <li><a href="/wiki/Oripavine" title="Oripavine">Oripavine</a></li> <li><a href="/wiki/Oxilorphan" title="Oxilorphan">Oxilorphan</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a></li> <li><a href="/wiki/Pentazocine" title="Pentazocine">Pentazocine</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Phenazocine" title="Phenazocine">Phenazocine</a></li> <li><a href="/wiki/Proxorphan" title="Proxorphan">Proxorphan</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/RB-64" title="RB-64">RB-64</a></li> <li><a href="/wiki/Salvinorin_A" title="Salvinorin A">Salvinorin A</a> (<a href="/wiki/Salvia_divinorum" title="Salvia divinorum">salvia</a>)</li> <li><a href="/wiki/Salvinorin_B_ethoxymethyl_ether" class="mw-redirect" title="Salvinorin B ethoxymethyl ether">Salvinorin B ethoxymethyl ether</a></li> <li><a href="/wiki/Salvinorin_B_methoxymethyl_ether" title="Salvinorin B methoxymethyl ether">Salvinorin B methoxymethyl ether</a></li> <li><a href="/wiki/Samidorphan" title="Samidorphan">Samidorphan</a></li> <li><a href="/wiki/Spiradoline" title="Spiradoline">Spiradoline</a> (U-62066)</li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li> <li><a href="/wiki/Tifluadom" title="Tifluadom">Tifluadom</a></li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="/wiki/Amitriptyline" title="Amitriptyline">amitriptyline</a>, <a href="/wiki/Desipramine" title="Desipramine">desipramine</a>, <a href="/wiki/Imipramine" title="Imipramine">imipramine</a>, <a href="/wiki/Nortriptyline" title="Nortriptyline">nortriptyline</a>)</li> <li><a href="/wiki/U-50488" title="U-50488">U-50488</a></li> <li><a href="/w/index.php?title=U-54494A&action=edit&redlink=1" class="new" title="U-54494A (page does not exist)">U-54494A</a></li> <li><a href="/wiki/U-69593" class="mw-redirect" title="U-69593">U-69593</a></li> <li><a href="/wiki/Xorphanol" title="Xorphanol">Xorphanol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/4%E2%80%B2-Hydroxyflavanone" class="mw-redirect" title="4′-Hydroxyflavanone">4′-Hydroxyflavanone</a></li> <li><a href="/wiki/4%27,7-Dihydroxyflavone" title="4',7-Dihydroxyflavone">4',7-Dihydroxyflavone</a></li> <li><a href="/wiki/5%27-Guanidinonaltrindole" title="5'-Guanidinonaltrindole">5'-GNTI</a></li> <li><a href="/wiki/6%27-Guanidinonaltrindole" title="6'-Guanidinonaltrindole">6'-GNTI</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol" title="6β-Naltrexol">6β-Naltrexol</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol-d4" title="6β-Naltrexol-d4">6β-Naltrexol-d4</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Buprenorphine/samidorphan" title="Buprenorphine/samidorphan">Buprenorphine/samidorphan</a></li> <li><a href="/wiki/Amentoflavone" title="Amentoflavone">Amentoflavone</a></li> <li><a href="/w/index.php?title=5%27-Acetamidinoethylnaltrindole&action=edit&redlink=1" class="new" title="5'-Acetamidinoethylnaltrindole (page does not exist)">ANTI</a></li> <li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a></li> <li><a href="/w/index.php?title=Arodyne&action=edit&redlink=1" class="new" title="Arodyne (page does not exist)">Arodyne</a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/wiki/Aticaprant" title="Aticaprant">Aticaprant</a></li> <li><a href="/wiki/Axelopran" title="Axelopran">Axelopran</a></li> <li><a href="/w/index.php?title=AZ-MTAB&action=edit&redlink=1" class="new" title="AZ-MTAB (page does not exist)">AZ-MTAB</a></li> <li><a href="/wiki/Binaltorphimine" title="Binaltorphimine">Binaltorphimine</a></li> <li><a href="/wiki/BU09059" title="BU09059">BU09059</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Catechin" title="Catechin">Catechin</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">Catechin gallate</a></li> <li><a href="/wiki/CERC-501" class="mw-redirect" title="CERC-501">CERC-501 (LY-2456302)</a></li> <li><a href="/wiki/Clocinnamox" title="Clocinnamox">Clocinnamox</a></li> <li><a href="/wiki/Icalcaprant" title="Icalcaprant">CVL-354</a></li> <li><a href="/w/index.php?title=Cyclofoxy&action=edit&redlink=1" class="new" title="Cyclofoxy (page does not exist)">Cyclofoxy</a></li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/w/index.php?title=DIPPA&action=edit&redlink=1" class="new" title="DIPPA (page does not exist)">DIPPA</a></li> <li><a href="/wiki/Gallocatechol" title="Gallocatechol">EGC</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a></li> <li><a href="/wiki/Epicatechin" class="mw-redirect" title="Epicatechin">Epicatechin</a></li> <li><a href="/wiki/Hyperoside" title="Hyperoside">Hyperoside</a></li> <li><a href="/wiki/JDTic" title="JDTic">JDTic</a></li> <li><a href="/wiki/LY-255582" title="LY-255582">LY-255582</a></li> <li><a href="/wiki/LY-2196044" class="mw-redirect" title="LY-2196044">LY-2196044</a></li> <li><a href="/w/index.php?title=LY-2444296&action=edit&redlink=1" class="new" title="LY-2444296 (page does not exist)">LY-2444296</a></li> <li><a href="/wiki/LY-2459989" title="LY-2459989">LY-2459989</a></li> <li><a href="/w/index.php?title=LY-2795050&action=edit&redlink=1" class="new" title="LY-2795050 (page does not exist)">LY-2795050</a></li> <li><a href="/w/index.php?title=MeJDTic&action=edit&redlink=1" class="new" title="MeJDTic (page does not exist)">MeJDTic</a></li> <li><a href="/wiki/Methylnaltrexone" title="Methylnaltrexone">Methylnaltrexone</a></li> <li><a href="/w/index.php?title=ML190&action=edit&redlink=1" class="new" title="ML190 (page does not exist)">ML190</a></li> <li><a href="/w/index.php?title=ML350&action=edit&redlink=1" class="new" title="ML350 (page does not exist)">ML350</a></li> <li><a href="/w/index.php?title=MR-2266&action=edit&redlink=1" class="new" title="MR-2266 (page does not exist)">MR-2266</a></li> <li><a href="/w/index.php?title=N-Fluoropropyl-JDTic&action=edit&redlink=1" class="new" title="N-Fluoropropyl-JDTic (page does not exist)">N-Fluoropropyl-JDTic</a></li> <li><a href="/wiki/Naloxone" title="Naloxone">Naloxone</a></li> <li><a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a></li> <li><a href="/wiki/Naltrindole" title="Naltrindole">Naltrindole</a></li> <li><a href="/wiki/Naringenin" title="Naringenin">Naringenin</a></li> <li><a href="/wiki/Navacaprant" title="Navacaprant">Navacaprant</a></li> <li><a href="/wiki/Norbinaltorphimine" title="Norbinaltorphimine">Norbinaltorphimine</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Pawhuskin_A" title="Pawhuskin A">Pawhuskin A</a></li> <li><a href="/wiki/PF-4455242" class="mw-redirect" title="PF-4455242">PF-4455242</a></li> <li><a href="/wiki/RB-64" title="RB-64">RB-64</a></li> <li><a href="/wiki/Quadazocine" title="Quadazocine">Quadazocine</a></li> <li><a href="/wiki/Taxifolin" title="Taxifolin">Taxifolin</a></li> <li><a href="/w/index.php?title=UPHIT&action=edit&redlink=1" class="new" title="UPHIT (page does not exist)">UPHIT</a></li> <li><a href="/wiki/Zyklophin" title="Zyklophin">Zyklophin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Nociceptin_receptor" title="Nociceptin receptor">Nociceptin</a><br />(NOP)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=(Arg14,Lys15)Nociceptin&action=edit&redlink=1" class="new" title="(Arg14,Lys15)Nociceptin (page does not exist)">(Arg14,Lys15)Nociceptin</a></li> <li><a href="/w/index.php?title=((pF)Phe4)Nociceptin(1-13)NH2&action=edit&redlink=1" class="new" title="((pF)Phe4)Nociceptin(1-13)NH2 (page does not exist)">((pF)Phe<sup>4</sup>)Nociceptin(1-13)NH<sub>2</sub></a></li> <li><a href="/w/index.php?title=(Phe1%CE%A8(CH2-NH)Gly2)Nociceptin(1-13)NH2&action=edit&redlink=1" class="new" title="(Phe1Ψ(CH2-NH)Gly2)Nociceptin(1-13)NH2 (page does not exist)">(Phe<sup>1</sup>Ψ(CH<sub>2</sub>-NH)Gly<sup>2</sup>)Nociceptin(1-13)NH<sub>2</sub></a></li> <li><a href="/w/index.php?title=Ac-RYYRWK-NH2&action=edit&redlink=1" class="new" title="Ac-RYYRWK-NH2 (page does not exist)">Ac-RYYRWK-NH<sub>2</sub></a></li> <li><a href="/w/index.php?title=Ac-RYYRIK-NH2&action=edit&redlink=1" class="new" title="Ac-RYYRIK-NH2 (page does not exist)">Ac-RYYRIK-NH<sub>2</sub></a></li> <li><a href="/w/index.php?title=BU08070&action=edit&redlink=1" class="new" title="BU08070 (page does not exist)">BU08070</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/w/index.php?title=JNJ-19385899&action=edit&redlink=1" class="new" title="JNJ-19385899 (page does not exist)">JNJ-19385899</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/MCOPPB" title="MCOPPB">MCOPPB</a></li> <li><a href="/wiki/MT-7716" title="MT-7716">MT-7716</a></li> <li><a href="/wiki/NNC_63-0532" title="NNC 63-0532">NNC 63-0532</a></li> <li><a href="/wiki/Nociceptin" title="Nociceptin">Nociceptin (orphanin FQ)</a></li> <li><a href="/w/index.php?title=Nociceptin_(1-11)&action=edit&redlink=1" class="new" title="Nociceptin (1-11) (page does not exist)">Nociceptin (1-11)</a></li> <li><a href="/w/index.php?title=Nociceptin_(1-13)NH2&action=edit&redlink=1" class="new" title="Nociceptin (1-13)NH2 (page does not exist)">Nociceptin (1-13)NH<sub>2</sub></a></li> <li><a href="/wiki/Norbuprenorphine" title="Norbuprenorphine">Norbuprenorphine</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/Ro64-6198" title="Ro64-6198">Ro64-6198</a></li> <li><a href="/wiki/Ro65-6570" title="Ro65-6570">Ro65-6570</a></li> <li><a href="/wiki/SCH-221510" title="SCH-221510">SCH-221510</a></li> <li><a href="/w/index.php?title=SCH-486757&action=edit&redlink=1" class="new" title="SCH-486757 (page does not exist)">SCH-486757</a></li> <li><a href="/w/index.php?title=SR-8993&action=edit&redlink=1" class="new" title="SR-8993 (page does not exist)">SR-8993</a></li> <li><a href="/wiki/SR-16435" title="SR-16435">SR-16435</a></li> <li><a href="/wiki/Sunobinop" title="Sunobinop">Sunobinop (S-117957)</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=(Nphe1)Nociceptin(1-13)NH2&action=edit&redlink=1" class="new" title="(Nphe1)Nociceptin(1-13)NH2 (page does not exist)">(Nphe<sup>1</sup>)Nociceptin(1-13)NH<sub>2</sub></a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/w/index.php?title=BAN-ORL-24&action=edit&redlink=1" class="new" title="BAN-ORL-24 (page does not exist)">BAN-ORL-24</a></li> <li><a href="/wiki/BTRX-246040" title="BTRX-246040">BTRX-246040 (LY-2940094)</a></li> <li><a href="/wiki/J-113397" class="mw-redirect" title="J-113397">J-113397</a></li> <li><a href="/wiki/JTC-801" title="JTC-801">JTC-801</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/w/index.php?title=Nociceptin_(1-7)&action=edit&redlink=1" class="new" title="Nociceptin (1-7) (page does not exist)">Nociceptin (1-7)</a></li> <li><a href="/w/index.php?title=Nocistatin&action=edit&redlink=1" class="new" title="Nocistatin (page does not exist)">Nocistatin</a></li> <li><a href="/wiki/SB-612111" class="mw-redirect" title="SB-612111">SB-612111</a></li> <li><a href="/w/index.php?title=SR-16430&action=edit&redlink=1" class="new" title="SR-16430 (page does not exist)">SR-16430</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li> <li><a href="/w/index.php?title=Trap-101&action=edit&redlink=1" class="new" title="Trap-101 (page does not exist)">Trap-101</a></li> <li><a href="/w/index.php?title=UFP-101&action=edit&redlink=1" class="new" title="UFP-101 (page does not exist)">UFP-101</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Enkephalinase_inhibitor" title="Enkephalinase inhibitor">Enkephalinase inhibitors</a>:</i> <a href="/wiki/Amastatin" title="Amastatin">Amastatin</a></li> <li><a href="/w/index.php?title=BL-2401&action=edit&redlink=1" class="new" title="BL-2401 (page does not exist)">BL-2401</a></li> <li><a href="/wiki/Candoxatril" title="Candoxatril">Candoxatril</a></li> <li><a href="/wiki/Phenylalanine#D-,_L-_and_DL-phenylalanine" title="Phenylalanine"><span style="font-size:85%;">D</span>-Phenylalanine</a></li> <li><a href="/w/index.php?title=Dexecadotril&action=edit&redlink=1" class="new" title="Dexecadotril (page does not exist)">Dexecadotril (retorphan)</a></li> <li><a href="/wiki/Ecadotril" title="Ecadotril">Ecadotril (sinorphan)</a></li> <li><a href="/wiki/Kelatorphan" title="Kelatorphan">Kelatorphan</a></li> <li><a href="/wiki/Racecadotril" title="Racecadotril">Racecadotril (acetorphan)</a></li> <li><a href="/wiki/RB-101" title="RB-101">RB-101</a></li> <li><a href="/wiki/RB-120" title="RB-120">RB-120</a></li> <li><a href="/wiki/RB-3007" title="RB-3007">RB-3007</a></li> <li><a href="/w/index.php?title=Opiorphan&action=edit&redlink=1" class="new" title="Opiorphan (page does not exist)">Opiorphan</a></li> <li><a href="/wiki/Selank" title="Selank">Selank</a></li> <li><a href="/wiki/Semax" title="Semax">Semax</a></li> <li><a href="/wiki/Spinorphin" title="Spinorphin">Spinorphin</a></li> <li><a href="/wiki/Thiorphan" title="Thiorphan">Thiorphan</a></li> <li><a href="/wiki/Tynorphin" title="Tynorphin">Tynorphin</a></li> <li><a href="/wiki/Ubenimex" title="Ubenimex">Ubenimex (bestatin)</a></li></ul> <ul><li><i>Propeptides:</i> <a href="/wiki/Lipotropin" title="Lipotropin">β-Lipotropin (proendorphin)</a></li> <li><a href="/wiki/Prodynorphin" title="Prodynorphin">Prodynorphin</a></li> <li><a href="/wiki/Proenkephalin" title="Proenkephalin">Proenkephalin</a></li> <li><a href="/w/index.php?title=Pronociceptin&action=edit&redlink=1" class="new" title="Pronociceptin (page does not exist)">Pronociceptin</a></li> <li><a href="/wiki/Proopiomelanocortin" title="Proopiomelanocortin">Proopiomelanocortin (POMC)</a></li></ul> <ul><li><i>Others:</i> <a href="/wiki/Kyotorphin" title="Kyotorphin">Kyotorphin</a> (met-enkephalin releaser/degradation stabilizer)</li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img 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