Article - Kne Open

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the impact of global warming on cancer development, specifically focusing on the intensified effects of environmental carcinogens such as ultraviolet (UV) radiation and air pollutants. 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Our review elucidates the intricate interplay between global warming, ecological carcinogens, h..."><meta name="twitter:image" content="https://knepublishing.com/public/journals/52/cover_issue_494_en_US.png"><meta name="gs_meta_revision" content="1.1"/><meta name="citation_journal_title" content="West Kazakhstan Medical Journal"/><meta name="citation_journal_abbrev" content="WKMJ"/><meta name="citation_issn" content="2707-6180 (Print) 2707-6199 (Online)"/><meta name="citation_author" content="Pardis Shirkani"/><meta name="citation_author_institution" content="Department of Science, University of British Columbia, Vancouver, British Columbia V6T 1Z4"/><meta name="citation_author" content="Afshin Shirkani"/><meta name="citation_author_institution" content="Allergy and Clinical Immunology Department, Bushehr University of Medical Science, School of Medicine, Bushehr"/><meta name="citation_title" content="Impact of Global Warming on Cancer Development: A Review of Environmental Carcinogens and Human Immunogenetics"/><meta name="citation_date" content="2024/09/26"/><meta name="citation_volume" content="66"/><meta name="citation_issue" content="3"/><meta name="citation_firstpage" content="210–238"/><meta name="citation_lastpage" content="210–238"/><meta name="citation_doi" content="10.18502/wkmj.v66i3.15772"/><meta name="citation_abstract_html_url" content="kneopen.com/wkmj/article/view/15772/"/><meta name="citation_language" content="en"/><meta name="citation_pdf_url" content="https://knepublishing.com/index.php/wkmj/article/view/15772/27040"/><meta name="citation_fulltext_html_url" content="http://kneopen.com/article/html/wkmj/15772/27041"/><link rel="icon" href="https://kneopen.com/wp-content/uploads/2024/05/KneOpen_ico_no_bg-150x150.png" sizes="32x32" /> <link rel="icon" href="https://kneopen.com/wp-content/uploads/2024/05/KneOpen_ico_no_bg-300x300.png" sizes="192x192" /> <link rel="apple-touch-icon" href="https://kneopen.com/wp-content/uploads/2024/05/KneOpen_ico_no_bg-300x300.png" /> <meta name="msapplication-TileImage" content="https://kneopen.com/wp-content/uploads/2024/05/KneOpen_ico_no_bg-300x300.png" /> <style type="text/css" id="wp-custom-css"> .about-menu-class ul { list-style: none; 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display: inline-block; cursor: pointer; } .auth_tooltip small{ display: block; text-align: left; margin-bottom: 8px; line-height: 16px; word-wrap: break-word; } .auth_tooltip .auth_tooltip-text { visibility: hidden; width: 200px; background-color: #fff; color: #555; text-align: center; border-radius: 6px; padding: 10px; position: absolute; z-index: 1; box-shadow: 0px 4px 8px rgba(0, 0, 0, 0.2); transition: opacity 0.3s; opacity: 0; border: 1px solid #407bbf; bottom: -8px; margin-left: 14px; } .auth_tooltip:hover .auth_tooltip-text { visibility: visible; opacity: 1; } .auth_tooltip .auth_tooltip-text::after { content: ' '; position: absolute; bottom: 6px; left: -22px; margin-top: 0; border-width: 11px; border-style: solid; border-color: transparent #407bbf transparent transparent; } </style> <div id="authors-list-new"> <p><span class="auth_tooltip"><a href="https://orcid.org/0009-0002-8969-1807" target="_blank">Pardis Shirkani</a><span class="auth_tooltip-text"><small><a href='mailto:pardisshirkani@yahoo.com'>pardisshirkani@yahoo.com</a></small><small>Department of Science, University of British Columbia, Vancouver, British Columbia V6T 1Z4</small></span></span></p><p><span class="auth_tooltip"><a href="https://orcid.org/0000-0002-0514-3620" target="_blank">Afshin Shirkani</a><span class="auth_tooltip-text"><small><a href='mailto:a.shirkani@bpums.ac.ir'>a.shirkani@bpums.ac.ir</a></small><small>Allergy and Clinical Immunology Department, Bushehr University of Medical Science, School of Medicine, Bushehr</small></span></span></p></div> <h5>Abstract:</h5> <div id="abstract-div"> <p>This paper examines the impact of global warming on cancer development, specifically focusing on the intensified effects of environmental carcinogens such as ultraviolet (UV) radiation and air pollutants. Our review elucidates the intricate interplay between global warming, ecological carcinogens, human immunogenetics, and cancer susceptibility. The analysis highlights the exacerbating effects of rising temperatures and changes in atmospheric conditions on exposure to UV radiation and air pollutants, including particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs), nitrogen dioxide (NO<sub>2</sub>), nitrogen oxides (NOx), and ground-level ozone (O<sub>3</sub>). Furthermore, the study explores the pivotal role of human immunogenetics in modulating individual responses to carcinogen exposure and shaping cancer susceptibility and progression. Genetic variations in key immune-related genes and their influence on the interplay between environmental carcinogens and cancer development are discussed. The paper underscores the importance of longitudinal cohort studies, integrative approaches, and interdisciplinary collaborations to advance our understanding of the complex interactions between global warming, environmental carcinogens, human immunogenetics, and cancer biology. Additionally, evidence-based public health interventions targeting environmental carcinogens and personalized prevention strategies based on genetic susceptibility profiles and environmental exposure assessments are proposed to address the growing challenges of environmentally induced cancers.</p> <p><strong>Keywords:</strong> global warming, environmental carcinogens, cancer immunogenetics, ultraviolet radiation, air pollutants, genetic susceptibility</p> </div> <h5>References:</h5> <div id="references-div"> <p> [1] Berrang-Ford L, Sietsma AJ, Callaghan M, Minx JC, Scheelbeek PF, Haddaway NR, et al. Systematic mapping of global research on climate and health: a machine learning review. 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