CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Frank Gruijl - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="dB3BRful-1Oax_UkOH3IqovaM6lA4yRzYvQ_iqQzNcpn6bYtDnAUFfpikzlHIk4NPWaUH1ZJczgTzu5CNVkKPA" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-3d36c19b4875b226bfed0fcba1dcea3f2fe61148383d97c0465c016b8c969290.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-79e78ce59bef0a338eb6540ec3d93b4a7952115b56c57f1760943128f4544d42.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-95367dc03b794f6737f30123738a886cf53b7a65cdef98a922a98591d60063e3.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-bfbac2a470372e2f3a6661a65fa7ff0a0fbf7aa32534d9a831d683d2a6f9e01b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-170d1319f0e354621e81ca17054bb147da2856ec0702fe440a99af314a6338c5.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-2b6f90dbd75f5941bc38f4ad716615f3ac449e7398313bb3bc225fba451cd9fa.css" /> <meta name="author" content="frank gruijl" /> <meta name="description" content="Frank Gruijl: 36 Followers, 14 Following, 269 Research papers. Research interests: Tics and education, Tecnologías emergentes, and El uso de las TIC en…" /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = 'b092bf3a3df71cf13feee7c143e83a57eb6b94fb'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":14016,"monthly_visitors":"99 million","monthly_visitor_count":99567017,"monthly_visitor_count_in_millions":99,"user_count":283016545,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1739838695000); window.Aedu.timeDifference = new Date().getTime() - 1739838695000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link rel="preload" href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" as="style" onload="this.rel='stylesheet'"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-40698df34f913bd208bb70f09d2feb7c6286046250be17a4db35bba2c08b0e2f.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-a22f75d8519394c21253dae46c8c5d60ad36ea68c7d494347ec64229d8c1cf85.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-5708a105dd66b4c7d0ef30b7c094b1048423f0042bd2a7b123f2d99ee3cf46d9.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://independent.academia.edu/FrankGruijl" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-c0b60aedadfb9d46b698730fbbcb2e70645c886b405d825adeba3a031c02455d.js" defer="defer"></script><script>$viewedUser = Aedu.User.set_viewed( {"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl","photo":"/images/s65_no_pic.png","has_photo":false,"is_analytics_public":false,"interests":[{"id":262825,"name":"Tics and education","url":"https://www.academia.edu/Documents/in/Tics_and_education"},{"id":501578,"name":"Tecnologías emergentes","url":"https://www.academia.edu/Documents/in/Tecnolog%C3%ADas_emergentes"},{"id":527148,"name":"El uso de las TIC en Educación Primaria","url":"https://www.academia.edu/Documents/in/El_uso_de_las_TIC_en_Educacion_Primaria"},{"id":48852,"name":"Usos didácticos de la pizarra digital","url":"https://www.academia.edu/Documents/in/Usos_didacticos_de_la_pizarra_digital"},{"id":68309,"name":"Uso pedagógico de las tecnologías de la información y la comunicación","url":"https://www.academia.edu/Documents/in/Uso_pedagogico_de_las_tecnologias_de_la_informacion_y_la_comunicacion"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/FrankGruijl","location":"/FrankGruijl","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/FrankGruijl","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-0d74adb8-22a5-4d64-9eec-00ba3f3fd31a"></div> <div id="ProfileCheckPaperUpdate-react-component-0d74adb8-22a5-4d64-9eec-00ba3f3fd31a"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Frank Gruijl</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Frank" data-follow-user-id="35121385" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="35121385"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">36</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">14</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">13</p></div></a><div class="js-mentions-count-container" style="display: none;"><a href="/FrankGruijl/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data"></p></div></a></div><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/SeijiKawana"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/SeijiKawana">Seiji Kawana</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/JohanGarssen"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/JohanGarssen">Johan Garssen</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/CamillaLieske"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/CamillaLieske">Camilla Lieske</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/pAskenase"><img class="profile-avatar u-positionAbsolute" alt="phil Askenase" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/6165691/51102712/39160521/s200_phil.askenase.jpeg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/pAskenase">phil Askenase</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://erasmusmc.academia.edu/AdriVanOudenaren"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://erasmusmc.academia.edu/AdriVanOudenaren">Adri Van Oudenaren</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">ErasmusMC Rotterdam</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/FrankDeGruijl"><img class="profile-avatar u-positionAbsolute" alt="Frank De Gruijl" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/44133183/160793146/150501701/s200_frank.de_gruijl.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/FrankDeGruijl">Frank De Gruijl</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/LindaRogers8"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/LindaRogers8">Linda Rogers</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://wur.academia.edu/HuubSavelkoul"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://wur.academia.edu/HuubSavelkoul">Huub Savelkoul</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Wageningen University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://utas.academia.edu/KonradMuller"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://utas.academia.edu/KonradMuller">Konrad Muller</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Tasmania</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://healthfoodinnovationmanagement.academia.edu/HenkVanLoveren"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://healthfoodinnovationmanagement.academia.edu/HenkVanLoveren">Henk Van Loveren</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Maastricht University, Faculty of Health Medicine and Life sciences</p></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="35121385" href="https://www.academia.edu/Documents/in/Tics_and_education"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/FrankGruijl","location":"/FrankGruijl","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/FrankGruijl","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Tics and education"]}" data-trace="false" data-dom-id="Pill-react-component-6372168e-c099-4780-85fc-3af8d71914c4"></div> <div id="Pill-react-component-6372168e-c099-4780-85fc-3af8d71914c4"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="35121385" href="https://www.academia.edu/Documents/in/Tecnolog%C3%ADas_emergentes"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Tecnologías emergentes"]}" data-trace="false" data-dom-id="Pill-react-component-b69b7460-24e6-4250-96c8-6e6ff49b3717"></div> <div id="Pill-react-component-b69b7460-24e6-4250-96c8-6e6ff49b3717"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="35121385" href="https://www.academia.edu/Documents/in/El_uso_de_las_TIC_en_Educacion_Primaria"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["El uso de las TIC en Educación Primaria"]}" data-trace="false" data-dom-id="Pill-react-component-f1fe8643-24e6-4d72-a270-d756c8f419ed"></div> <div id="Pill-react-component-f1fe8643-24e6-4d72-a270-d756c8f419ed"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="35121385" href="https://www.academia.edu/Documents/in/Usos_didacticos_de_la_pizarra_digital"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Usos didácticos de la pizarra digital"]}" data-trace="false" data-dom-id="Pill-react-component-efe2315b-2b41-4202-b4e4-946c8ebb0258"></div> <div id="Pill-react-component-efe2315b-2b41-4202-b4e4-946c8ebb0258"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="35121385" href="https://www.academia.edu/Documents/in/Uso_pedagogico_de_las_tecnologias_de_la_informacion_y_la_comunicacion"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Uso pedagógico de las tecnologías de la información y la comun..."]}" data-trace="false" data-dom-id="Pill-react-component-bcf13c33-bbe9-4ca5-a0b6-bbc41dc91d50"></div> <div id="Pill-react-component-bcf13c33-bbe9-4ca5-a0b6-bbc41dc91d50"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Frank Gruijl</h3></div><div class="js-work-strip profile--work_container" data-work-id="110872782"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872782/Ultraviolet_Radiation_Induced_Impairment_of_the_Early_Initiating_and_the_Late_Effector_Phases_of_Contact_Hypersensitivity_to_Picrylcholoride_Regulation_by_Different_Mechanisms"><img alt="Research paper thumbnail of Ultraviolet Radiation-Induced Impairment of the Early Initiating and the Late Effector Phases of Contact Hypersensitivity to Picrylcholoride: Regulation by Different Mechanisms" class="work-thumbnail" src="https://attachments.academia-assets.com/108555426/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872782/Ultraviolet_Radiation_Induced_Impairment_of_the_Early_Initiating_and_the_Late_Effector_Phases_of_Contact_Hypersensitivity_to_Picrylcholoride_Regulation_by_Different_Mechanisms">Ultraviolet Radiation-Induced Impairment of the Early Initiating and the Late Effector Phases of Contact Hypersensitivity to Picrylcholoride: Regulation by Different Mechanisms</a></div><div class="wp-workCard_item"><span>Journal of Investigative Dermatology</span><span>, Jun 1, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">'fwo types of antigen-specific T cells are needed for the elicitation of contact hypersensitivity...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">'fwo types of antigen-specific T cells are needed for the elicitation of contact hypersensitivity reactions. They act in an obligate sequence to mediate the early initiating and late effector phases of contact hypersensitivity, which are accompanied by skin-swelling responses at 2 and 24 h after challenge, respectively. The magnitude of the late ear swelling depends on that of the early swelling. We studied the influence of ultraviolet radiation on both phases of contact hypersensitivity to picrylchloride. Mice were exposed to subedemal doses of ultraviolet radiation on the shaved backs for four consecutive days. Four days later mice were sensitized on non-irradiated skin. Four days after sensitization mice were challenged on the ears, and swelling was measured 2, 4, and 24 h after challenge. The early and T he immunosuppressive properties of ultraviolet radiation (UVR) have been known for several years. Studies of Fisher and Kripke [1,2] and of Spellman et af [3] showed in inbred mice that the UVR-induced suppression of rejection of highly antigenic, UVR-induced tumors is transferable with lymphoid cells. UVR also suppresses delayed-type hypersensitivity (DTH) to a variety of antigens such as haptens [4,5], allogeneic sfleen cells [6,7], viruses [S], bacteria [9], fungi [10] , and parasites 11]. DTH assays are convenient assays to study the mechanisms of UVR-induced suppression of cellular immunity because they are relatively easy to perform. In the above-mentioned studies, the suppression of the "classical" DTH reaction, measurable as a skin-swelling reaction that peaks 24-4S h after antigen challenge, was investigated. However, Van Loveren and colleagues reported that elicitation of murine DTH reactions is dependent on the sequential activities of at least two different antigen-specific Thy-1+, CDS+, CDS-cells [12,13]. These two different T cells medii\te separate ea rly and late steps in the DTH reaction that are accompanied by maximum skin swellings at 2 and 24 h after challenge lI2-1S]. More recently the phenotype of these cells was more extensively characterized [14]. The early DTH-initiating cell , which has recently been cloned [16], is Manuscript</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bf84d81c5cbeb0a163d30fd13b607874" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555426,"asset_id":110872782,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555426/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872782"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872782"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872782; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872782]").text(description); $(".js-view-count[data-work-id=110872782]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872782; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872782']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bf84d81c5cbeb0a163d30fd13b607874" } } $('.js-work-strip[data-work-id=110872782]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872782,"title":"Ultraviolet Radiation-Induced Impairment of the Early Initiating and the Late Effector Phases of Contact Hypersensitivity to Picrylcholoride: Regulation by Different Mechanisms","internal_url":"https://www.academia.edu/110872782/Ultraviolet_Radiation_Induced_Impairment_of_the_Early_Initiating_and_the_Late_Effector_Phases_of_Contact_Hypersensitivity_to_Picrylcholoride_Regulation_by_Different_Mechanisms","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555426,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555426/thumbnails/1.jpg","file_name":"82733693.pdf","download_url":"https://www.academia.edu/attachments/108555426/download_file","bulk_download_file_name":"Ultraviolet_Radiation_Induced_Impairment.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555426/82733693-libre.pdf?1702051123=\u0026response-content-disposition=attachment%3B+filename%3DUltraviolet_Radiation_Induced_Impairment.pdf\u0026Expires=1739842295\u0026Signature=WshsnuG7HrLJPuscohM1cAEDXgcfEQCQPP9aztSaE-cPAASIcBitJzfan-P-sMvnJlUAj03OlM2K2yzbydVtOJd9iIAoNGKYv9AnG5ry5HmwcF6OD3Wts6AsEdqwFGEz8v39bqT2Jzsc0j57DHxWEw0u8QZxH1BNooXXWHkq~sjZdhi4npk412aAwef29Hfc2rNcSR12MKNM6xltjR6XLTOsS-BIPEAEWbzqSBHVo4a4W6UtaDasOFcWKkYa1pbMUeQO5bwC12i3qCFF05DkGLgp-0h7NBQLZgMCZmyehiGXpEOwwDnxZoD9oVme0sYHksdnzGJ9JVHs8CzGkwqXOw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872781"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872781/Mismatch_repair_protein_Msh2_contributes_to_UVB_induced_cell_cycle_arrest_in_epidermal_and_cultured_mouse_keratinocytes"><img alt="Research paper thumbnail of Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes" class="work-thumbnail" src="https://attachments.academia-assets.com/108555427/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872781/Mismatch_repair_protein_Msh2_contributes_to_UVB_induced_cell_cycle_arrest_in_epidermal_and_cultured_mouse_keratinocytes">Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes</a></div><div class="wp-workCard_item"><span>DNA Repair</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Nucleotide excision repair (NER), cell cycle regulation and apoptosis are major defence mechanism...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Nucleotide excision repair (NER), cell cycle regulation and apoptosis are major defence mechanisms against the carcinogenic effects of UVB radiation. NER eliminates UVB-induced DNA photolesions via two subpathways: global genome repair (GGR) and transcription-coupled repair (TCR). In a previous study, we found UVB-induced accumulation of tetraploid (4N) keratinocytes in the epidermis of Xpc −/− mice (no GGR), but not in Xpa −/− (no TCR and no GGR) or in wild-type (WT) mice. We inferred that this arrest in Xpc −/− mice is caused by erroneous replication past photolesions, leading to 'compound lesions' known to be recognised by mismatch repair (MMR). MMR-induced futile cycles of breakage and resynthesis at sites of compound lesions may then sustain a cell cycle arrest. The present experiments with Xpc −/− Msh2 −/− mice and derived keratinocytes show that the MMR protein Msh2 indeed plays a role in the generation of the UVB-induced arrested cells: a Msh2-deficiency lowered significantly the percentage of arrested cells in vivo (40-50%) and in vitro (30-40%). Analysis of calyculin A (CA)-induced premature chromosome condensation (PCC) of cultured Xpc −/− keratinocytes showed that the delayed arrest occurred in late S phase rather than in G 2-phase. Taken together, the results indicate that in mouse epidermis and cultured keratinocytes, the MMR protein Msh2 plays a role in the UVB-induced S-phase arrest. This indicates that MMR plays a role in the UVB-induced S-phase arrest. Alternatively, Msh2 may have a more direct signalling function.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="39a757b73fb6b4ca56a653762a738e4f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555427,"asset_id":110872781,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555427/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872781"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872781"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872781; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872781]").text(description); $(".js-view-count[data-work-id=110872781]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872781; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872781']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "39a757b73fb6b4ca56a653762a738e4f" } } $('.js-work-strip[data-work-id=110872781]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872781,"title":"Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes","internal_url":"https://www.academia.edu/110872781/Mismatch_repair_protein_Msh2_contributes_to_UVB_induced_cell_cycle_arrest_in_epidermal_and_cultured_mouse_keratinocytes","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555427,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555427/thumbnails/1.jpg","file_name":"j.dnarep.2004.08.00820231208-1-97xcx6.pdf","download_url":"https://www.academia.edu/attachments/108555427/download_file","bulk_download_file_name":"Mismatch_repair_protein_Msh2_contributes.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555427/j.dnarep.2004.08.00820231208-1-97xcx6-libre.pdf?1702051106=\u0026response-content-disposition=attachment%3B+filename%3DMismatch_repair_protein_Msh2_contributes.pdf\u0026Expires=1739842295\u0026Signature=Ztqbak3Mw3roveyR~hwLUyo~GmVit4yZRGYRKUDPBD2lTlfF2mA9muKUMRAs9oDTm0mzNyn0gKBBNxpB6q1PMFevBET6WWNYSXxsh2mAXa~wwQa8O~hVK6FzBHQZ76Kiq7fIkGZXnvSUXw0P9xc4r5o7bxiOhI1jwclFqmoYQL95D7NOlGpYwnW0iTBWSXjSXtzrhIc6OfUKqwvFd8kd8WDo0q5ymDS93awJizcdTfXsYtwWCQK0c46Pdf7c3Rvi2kP9ViDO6jNBt4WXeDBulpYNQyIcM3qocSsBP88WYUeSpvATnYMqrSBbsHhMPwR6UyOFdm9vweoO1MMmq~zeRA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872780"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872780/Effects_of_Ultraviolet_B_Exposure_on_the_Resistance_to_Listeria_monocytogenes_in_the_Rat"><img alt="Research paper thumbnail of Effects of Ultraviolet-B Exposure on the Resistance to Listeria monocytogenes in the Rat" class="work-thumbnail" src="https://attachments.academia-assets.com/108555433/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872780/Effects_of_Ultraviolet_B_Exposure_on_the_Resistance_to_Listeria_monocytogenes_in_the_Rat">Effects of Ultraviolet-B Exposure on the Resistance to Listeria monocytogenes in the Rat</a></div><div class="wp-workCard_item"><span>Photochemistry and Photobiology</span><span>, May 1, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A rat infection model using the bacterial pathogen Listeria monocytogenes was employed to analyze...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A rat infection model using the bacterial pathogen Listeria monocytogenes was employed to analyze the immunosuppressive activity of UVB radiation. Rats were exposed to suberythemal doses of UVB radiation for 5 or 7 consecutive days, using Kromayer or FS40 lamps respectively. Subsequently, the rats were infected subcutaneously or intravenously with Listeria. Exposure to UVB resulted in an increased number of bacteria in the spleen 4 days after infection. Listeria-specific lymphocyte proliferation assays as well as delayed-type hypersensitivity reactions demonstrated that T cell-mediated immunity to Listeria was impaired by UVB as measured 4 and 8 days after infection. In addition, UVB exposure decreased phagocytotic activity of peripheral blood macrophages. This study demonstrated that suberythemal doses of UVB radiation caused a delay in the clearance of Listeria bacteria from the spleen of the rats and that this was probably caused by impaired nonspecific phagocytosis of Listeria by macrophages in addition to an impaired activity of Listeria-specific T cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ba8a47f821ae3ed8fe6d4ec09409ed1a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555433,"asset_id":110872780,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555433/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872780"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872780"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872780; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872780]").text(description); $(".js-view-count[data-work-id=110872780]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872780; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872780']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ba8a47f821ae3ed8fe6d4ec09409ed1a" } } $('.js-work-strip[data-work-id=110872780]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872780,"title":"Effects of Ultraviolet-B Exposure on the Resistance to Listeria monocytogenes in the Rat","internal_url":"https://www.academia.edu/110872780/Effects_of_Ultraviolet_B_Exposure_on_the_Resistance_to_Listeria_monocytogenes_in_the_Rat","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555433,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555433/thumbnails/1.jpg","file_name":"j.1751-1097.1996.tb05672.x20231208-1-lpizfa.pdf","download_url":"https://www.academia.edu/attachments/108555433/download_file","bulk_download_file_name":"Effects_of_Ultraviolet_B_Exposure_on_the.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555433/j.1751-1097.1996.tb05672.x20231208-1-lpizfa-libre.pdf?1702051107=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Ultraviolet_B_Exposure_on_the.pdf\u0026Expires=1739842295\u0026Signature=a3vTAPRHItJkqmbBlfTuMHFKUUtnFTGrMluNy-lzZiGmd-toQxqOUoKkeBS-rkslWyUaLVqQBXoznh7318cEBJMZBioLsdnEUxr7QAqm19eSA0kQYfKn6e2wc4qUb9hwm8y11K~NdIDlLnZ3PR3OmKkH5tHKZetIoWVd5yuAvJrhEALu-9PDnkUaR0U3rW4aZ76JUUdsV-hGUg1e1YvHoO6lnWuk-LNoj8i4xYePl5raomZFJ9TkLe74J14ZRkxkE0aFZDcpUzJtnewjw23ZO~AEBPRbiIw9vtwNjFVBFeZDNje0WBB6nG8Y0zv0Lo0jTgYbs0-wmiOCzQ0Xt9txLA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872779"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872779/Epidermal_cis_Urocanic_Acid_Levels_Correlate_with_Lower_Specific_Cellular_Immune_Responses_After_Hepatitis_B_Vaccination_of_Ultraviolet_B_exposed_Humans_"><img alt="Research paper thumbnail of Epidermal cis-Urocanic Acid Levels Correlate with Lower Specific Cellular Immune Responses After Hepatitis B Vaccination of Ultraviolet B-exposed Humans¶" class="work-thumbnail" src="https://attachments.academia-assets.com/108555424/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872779/Epidermal_cis_Urocanic_Acid_Levels_Correlate_with_Lower_Specific_Cellular_Immune_Responses_After_Hepatitis_B_Vaccination_of_Ultraviolet_B_exposed_Humans_">Epidermal cis-Urocanic Acid Levels Correlate with Lower Specific Cellular Immune Responses After Hepatitis B Vaccination of Ultraviolet B-exposed Humans¶</a></div><div class="wp-workCard_item"><span>Photochemistry and Photobiology</span><span>, May 1, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Urocanic acid (UCA) is a major UV-absorbing chromophore in the epidermis and has been suggested t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Urocanic acid (UCA) is a major UV-absorbing chromophore in the epidermis and has been suggested to act as one of the initiators of UV-induced immunosuppression. cis-UCA, the isomer from UCA that is formed upon UV exposure, has been shown to impair some cellular immune responses. cis-UCA levels were determined in a study in which the influence of ultraviolet B (UVB) exposure on immune responses after hepatitis B vaccination in human volunteers was established. A significant increase in cis-UCA levels was found in the skin of UVB-exposed volunteers compared with controls. cis-UCA levels, calculated as the percentage of the total UCA amount, in UVB-exposed volunteers correlated significantly with the cumulative UVB dose received in 5 consecutive days, i.e. the higher the UVB dose (J/m 2), the higher the cis-UCA levels (until a cis-UCA plateau was reached in the so-called photostationary state). Correlations between skin cis-UCA levels and immune responses were determined, and they revealed no statistically significant correlations among lymphocyte proliferation responses after either mitogenic stimulation or stimulation with recall antigens. No correlation was found between cis-UCA levels and hepatitis B-specific antibody titers. However, we found a statistically significant negative correlation between cis-UCA levels and hepatitis Bspecific lymphocyte proliferation responses when volunteers were irradiated with UVB before hepatitis B vaccination. In other words, volunteers with high cis-UCA levels caused by UVB exposure showed lower cellular immune responses against hepatitis B antigen after hepatitis B vaccination.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b8e2923538d36267a9c53ef028378ee5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555424,"asset_id":110872779,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555424/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872779"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872779"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872779; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872779]").text(description); $(".js-view-count[data-work-id=110872779]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872779; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872779']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b8e2923538d36267a9c53ef028378ee5" } } $('.js-work-strip[data-work-id=110872779]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872779,"title":"Epidermal cis-Urocanic Acid Levels Correlate with Lower Specific Cellular Immune Responses After Hepatitis B Vaccination of Ultraviolet B-exposed Humans¶","internal_url":"https://www.academia.edu/110872779/Epidermal_cis_Urocanic_Acid_Levels_Correlate_with_Lower_Specific_Cellular_Immune_Responses_After_Hepatitis_B_Vaccination_of_Ultraviolet_B_exposed_Humans_","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555424,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555424/thumbnails/1.jpg","file_name":"0031-8655282003290770271ecualc2.0.co220231208-1-wjwmjv.pdf","download_url":"https://www.academia.edu/attachments/108555424/download_file","bulk_download_file_name":"Epidermal_cis_Urocanic_Acid_Levels_Corre.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555424/0031-8655282003290770271ecualc2.0.co220231208-1-wjwmjv-libre.pdf?1702051105=\u0026response-content-disposition=attachment%3B+filename%3DEpidermal_cis_Urocanic_Acid_Levels_Corre.pdf\u0026Expires=1739842295\u0026Signature=Bm6koTS1mPpPzj1C58wlGIrfUwpQPmiMGBRErkoWe3XSB-UHLHvhoA5bcauEpyywA7D1xvdod2flop0Vteow6pbtToS7EJH18R6ajIwo~2nP3m32dG7ZH~0V45T70f3894TVcktre5qCtdwJV2EZB3d3z71tWAWT7YrQkLttOm6pVuocINX38vf0RdcMyKkUTFs3TBsfVe0XIUgBtQETekgn0k4bRHyog16jirSiIcIlYvC2YYf-uJbOGw-PrtkbFS6gMMY6hQeRcXGYgCeXa-AHRj0SP1eO8w6D1J9Qcygj7I2HRWpPAtRT38fhymfKwRuPtUYnW7ke~yK17JwyEA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872778"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872778/UVB_Exposure_Impairs_Immune_Responses_After_Hepatitis_B_Vaccination_in_Two_Different_Mouse_Strains_"><img alt="Research paper thumbnail of UVB Exposure Impairs Immune Responses After Hepatitis B Vaccination in Two Different Mouse Strains¶" class="work-thumbnail" src="https://attachments.academia-assets.com/108555449/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872778/UVB_Exposure_Impairs_Immune_Responses_After_Hepatitis_B_Vaccination_in_Two_Different_Mouse_Strains_">UVB Exposure Impairs Immune Responses After Hepatitis B Vaccination in Two Different Mouse Strains¶</a></div><div class="wp-workCard_item"><span>Photochemistry and Photobiology</span><span>, May 1, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ultraviolet light exposure can impair immune responses that are not restricted to the exposed ski...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ultraviolet light exposure can impair immune responses that are not restricted to the exposed skin but is also found at other sites, i.e. systemic immunosuppression. Therefore, we investigated the UV-induced modulating effects on vaccination against hepatitis B in a mouse model. Two different mouse strains, BALB/c and C57Bl/ 6, were vaccinated intramuscularly against hepatitis B. Mice were exposed to different doses of ultraviolet B (UVB) for five consecutive days on shaved back skin before the vaccination. Vaccination against hepatitis B induced cellular (delayed-type hypersensitivity [DTH] and lymphocyte stimulation test) as well as humoral immune responses in both mouse strains. The DTH responses in C57Bl/6 mice were statistically significantly higher compared with BALB/c mice. UVB exposure induced a dosedependent suppression of cellular immunity in both strains of mice. C57Bl/6 mice seemed to be more susceptible to this suppression. Anti-hepatitis B surface antibodies (total-Ig) were only marginally suppressed after UVB exposure. IgG2a and interferon-␥ levels, both indicators for Th1 immune response, were suppressed in both mouse strains after UVB exposure. In summary, UVB exposure induced a dose-dependent suppression of both cellular and humoral immune responses after hep-¶Posted on the web site on</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3a04ee0ac3612cda0deb7340b4edc5be" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555449,"asset_id":110872778,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555449/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872778"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872778"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872778; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872778]").text(description); $(".js-view-count[data-work-id=110872778]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872778; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872778']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3a04ee0ac3612cda0deb7340b4edc5be" } } $('.js-work-strip[data-work-id=110872778]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872778,"title":"UVB Exposure Impairs Immune Responses After Hepatitis B Vaccination in Two Different Mouse Strains¶","internal_url":"https://www.academia.edu/110872778/UVB_Exposure_Impairs_Immune_Responses_After_Hepatitis_B_Vaccination_in_Two_Different_Mouse_Strains_","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555449,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555449/thumbnails/1.jpg","file_name":"0031-8655282002290750541ueiira2.0.co220231208-1-2kb29d.pdf","download_url":"https://www.academia.edu/attachments/108555449/download_file","bulk_download_file_name":"UVB_Exposure_Impairs_Immune_Responses_Af.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555449/0031-8655282002290750541ueiira2.0.co220231208-1-2kb29d-libre.pdf?1702051108=\u0026response-content-disposition=attachment%3B+filename%3DUVB_Exposure_Impairs_Immune_Responses_Af.pdf\u0026Expires=1739842295\u0026Signature=UUFPcFtN~7tVX-JC8eehYhIwSvpqS~nzOt1C0caZVqh9DC~Baz114oCCxacYwOALBPoISeGNcDSprWX7c7-9Qh1-dwLKK8NmeuI9sKhkjgQNZRyqWz4CchJmBvNlbOZXT1ZPc4cThrKr1cDzdM-4SYmtslXOpeZsyfYrr9l9-uEm5YCLUNNFCRfIccSr0RCxnyiazqxGH6xKa37l0f3kULneBwqlGA~DQpAcMB7ev2N~DPzUQ0vihSeRC7mjOIFXrpsIoijZQxUrOPcNUZMEtY~Fk~yguLZFhKooJnnFYiMELwyX7Q8ZnKKFDFwopnFQUsqbNSEYQ8oq7bc7zW3xkg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872777"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872777/Association_of_Transcription_Coupled_Repair_but_Not_Global_Genome_Repair_with_Ultraviolet_B_Induced_Langerhans_Cell_Depletion_and_Local_Immunosuppression"><img alt="Research paper thumbnail of Association of Transcription-Coupled Repair but Not Global Genome Repair with Ultraviolet-B-Induced Langerhans Cell Depletion and Local Immunosuppression" class="work-thumbnail" src="https://attachments.academia-assets.com/108555343/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872777/Association_of_Transcription_Coupled_Repair_but_Not_Global_Genome_Repair_with_Ultraviolet_B_Induced_Langerhans_Cell_Depletion_and_Local_Immunosuppression">Association of Transcription-Coupled Repair but Not Global Genome Repair with Ultraviolet-B-Induced Langerhans Cell Depletion and Local Immunosuppression</a></div><div class="wp-workCard_item"><span>Journal of Investigative Dermatology</span><span>, Oct 1, 2003</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="583fc2e3353413c44263f97bb0962848" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555343,"asset_id":110872777,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555343/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872777"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872777"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872777; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872777]").text(description); $(".js-view-count[data-work-id=110872777]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872777; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872777']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "583fc2e3353413c44263f97bb0962848" } } $('.js-work-strip[data-work-id=110872777]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872777,"title":"Association of Transcription-Coupled Repair but Not Global Genome Repair with Ultraviolet-B-Induced Langerhans Cell Depletion and Local Immunosuppression","internal_url":"https://www.academia.edu/110872777/Association_of_Transcription_Coupled_Repair_but_Not_Global_Genome_Repair_with_Ultraviolet_B_Induced_Langerhans_Cell_Depletion_and_Local_Immunosuppression","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555343,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555343/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/108555343/download_file","bulk_download_file_name":"Association_of_Transcription_Coupled_Rep.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555343/pdf-libre.pdf?1702051115=\u0026response-content-disposition=attachment%3B+filename%3DAssociation_of_Transcription_Coupled_Rep.pdf\u0026Expires=1739842295\u0026Signature=hJIc0aZAu3NszLj4m3Xj77e~r9nUghBYAXCrgSogs3vbFaFJxQ3wasccyunkSwg0svyxUgbPDQJ2O~7Pcrdcz5gD3A9fiq~XcVOzoSTDC33HP2kukMv7VkczsfBlrsgjY5qPCbF0R6lB3G0SqIGemjzS4pGOdEKM9Mb~d200HyMLQOul5xbgtnLYvERo6jypSRxiVt1rLh--oQ4AdCIhd~WgAx2QjzUCAnpKmLZ0XwV94sca-52WRY-OHDpbQVHSLqcC28SFm1bXX2h6THPvkZjuprkuvxcAqUbvt28rezR37xOZVuHj-uX7dSDv0ffeUY-yS0q8OyiBDDUabTkBWw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":108555342,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555342/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/108555342/download_file","bulk_download_file_name":"Association_of_Transcription_Coupled_Rep.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555342/pdf-libre.pdf?1702051115=\u0026response-content-disposition=attachment%3B+filename%3DAssociation_of_Transcription_Coupled_Rep.pdf\u0026Expires=1739842295\u0026Signature=BAsNOIwTdqAq8QO5IESLQZnQwJOpqNt3rxx6F6AMzZv1GysGU9ULNaxuclafU~rWGyCjslGwVdXq7MNEYM2ZCNXIQsWu9IwWDpROO5Pzf2NVPtAbW4bntdzcWoWfarKOk~FNyc8QAAWia0jURrsXwI-QLj1xdTeoeIsQnNmovMHg0fnk5vG6mYM0~t~24jvsxRvFy5RHzl5Ev0dCYvSnVNMieMDMzlw2qHk9ptE7eZEiDPrv3Pdn36jexPB7nzOl0O112hhZnnHrbHHhVzSr2Fo-~GYX7GsNSx8LBoe6N55TmgIxnSSVTQHvfC8~XQhmQwegyX5NZfi~lgBIK2rj3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872773"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872773/Supplementary_Table_1_Figures_1_4_from_Dietary_Immunosuppressants_Do_Not_Enhance_UV_Induced_Skin_Carcinogenesis_and_Reveal_Discordance_between_p53_Mutant_Early_Clones_and_Carcinomas"><img alt="Research paper thumbnail of Supplementary Table 1, Figures 1 - 4 from Dietary Immunosuppressants Do Not Enhance UV-Induced Skin Carcinogenesis, and Reveal Discordance between p53-Mutant Early Clones and Carcinomas" class="work-thumbnail" src="https://attachments.academia-assets.com/108555425/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872773/Supplementary_Table_1_Figures_1_4_from_Dietary_Immunosuppressants_Do_Not_Enhance_UV_Induced_Skin_Carcinogenesis_and_Reveal_Discordance_between_p53_Mutant_Early_Clones_and_Carcinomas">Supplementary Table 1, Figures 1 - 4 from Dietary Immunosuppressants Do Not Enhance UV-Induced Skin Carcinogenesis, and Reveal Discordance between p53-Mutant Early Clones and Carcinomas</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Supplementary figure 1; Effects of immunosuppressive drugs on epidermal proliferation in HSEs (n=...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Supplementary figure 1; Effects of immunosuppressive drugs on epidermal proliferation in HSEs (n=3-4) as % of Ki-67 positive (supra-)basal cells. ANOVA shows only Rapa to differ from control (p<0.05). Results for two concentrations of immunosuppressants are combined. Error bars depict SEM.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d1f07092edbbb10d3925ee089fa0b8e0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555425,"asset_id":110872773,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555425/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872773"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872773"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872773; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872773]").text(description); $(".js-view-count[data-work-id=110872773]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872773; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872773']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d1f07092edbbb10d3925ee089fa0b8e0" } } $('.js-work-strip[data-work-id=110872773]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872773,"title":"Supplementary Table 1, Figures 1 - 4 from Dietary Immunosuppressants Do Not Enhance UV-Induced Skin Carcinogenesis, and Reveal Discordance between p53-Mutant Early Clones and Carcinomas","internal_url":"https://www.academia.edu/110872773/Supplementary_Table_1_Figures_1_4_from_Dietary_Immunosuppressants_Do_Not_Enhance_UV_Induced_Skin_Carcinogenesis_and_Reveal_Discordance_between_p53_Mutant_Early_Clones_and_Carcinomas","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555425,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555425/thumbnails/1.jpg","file_name":"19406207capr120361-sup-capr-12-0361tab1fig1-4.pdf","download_url":"https://www.academia.edu/attachments/108555425/download_file","bulk_download_file_name":"Supplementary_Table_1_Figures_1_4_from_D.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555425/19406207capr120361-sup-capr-12-0361tab1fig1-4-libre.pdf?1702051104=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Table_1_Figures_1_4_from_D.pdf\u0026Expires=1739842295\u0026Signature=MEgQ9Rx1851-1uM1-Q-AvJBRHBtes-sBVxL5Kyzi-LICfOEkbD1x7UPm8T1UjnzZiTJO3RpK~4JaoduQxjIpIwrQzMclQgd4Zz1HLeMADRz4KlcEX-kMBFe~bWMN34iPvNie7vZ3-89H7RH2Af6S4RQPEJAW0I4~jN3v~bRH9~P~ucvxeyw9N5EzcXIZJzyEvKNuRf4MgYTHoJvNHN02ZCqdJdscChgIpdljf7Bvu7jP6AddAyW~tEc9xZHaA4IAI2PAy6vr2WoxmWve9m-ZND5ueOHwadamzbUIdk3vLyXKRiMBW5vqc2~EPnZAgQFLrylXaQpg~Ah4nOSsstUChg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872772"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872772/Risk_assessment_of_UVB_effects_on_resistance_to_infectious_diseases"><img alt="Research paper thumbnail of Risk assessment of UVB effects on resistance to infectious diseases" class="work-thumbnail" src="https://attachments.academia-assets.com/108555423/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872772/Risk_assessment_of_UVB_effects_on_resistance_to_infectious_diseases">Risk assessment of UVB effects on resistance to infectious diseases</a></div><div class="wp-workCard_item"><span>Toxicology Letters</span><span>, Aug 1, 1995</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="03c226294c34ea0c1bc9f91c24d3f04f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555423,"asset_id":110872772,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555423/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872772"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872772"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872772; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872772]").text(description); $(".js-view-count[data-work-id=110872772]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872772; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872772']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "03c226294c34ea0c1bc9f91c24d3f04f" } } $('.js-work-strip[data-work-id=110872772]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872772,"title":"Risk assessment of UVB effects on resistance to infectious diseases","internal_url":"https://www.academia.edu/110872772/Risk_assessment_of_UVB_effects_on_resistance_to_infectious_diseases","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555423,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555423/thumbnails/1.jpg","file_name":"03784-27492859294639X-20231208-1-368azp.pdf","download_url":"https://www.academia.edu/attachments/108555423/download_file","bulk_download_file_name":"Risk_assessment_of_UVB_effects_on_resist.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555423/03784-27492859294639X-20231208-1-368azp-libre.pdf?1702051105=\u0026response-content-disposition=attachment%3B+filename%3DRisk_assessment_of_UVB_effects_on_resist.pdf\u0026Expires=1739842295\u0026Signature=Pp4bCaakOSqScj3blkWAvV64OxyxjspuuJZJlHvEvLTBanEHXM3EbL~mcn5iu25DMDVURWZa9H88Pkv6b88oQVx0u1MvVK31xQi5mzWEhz5ZOp1eEUqcWRdnDmTj6wwfYf1PeYF5swk10sS7pti6wkvJAyGjgyMIb-4FeF4Lgi1ZfOJ1-WwOMFwRiNifYa-CpKYLPISLxF9YX2wSwrHGSIbYZSKs9VpIXBth3ZASFay2Hd61HFVjvjzqs5fXM2aFuUSKcxVvBpxd1gSLdk6UOnvEMh94F2MbQmG3am8-7x6fk2oVhutsyjwf37DrrFCHTfHdfQ9V7TI4y~5QjSDPqw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872770"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872770/Single_UVB_Overexposure_Stimulates_Melanocyte_Proliferation_in_Murine_Skin_in_Contrast_to_Fractionated_or_UVA_1_Exposure"><img alt="Research paper thumbnail of Single UVB Overexposure Stimulates Melanocyte Proliferation in Murine Skin, in Contrast to Fractionated or UVA-1 Exposure" class="work-thumbnail" src="https://attachments.academia-assets.com/108555432/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872770/Single_UVB_Overexposure_Stimulates_Melanocyte_Proliferation_in_Murine_Skin_in_Contrast_to_Fractionated_or_UVA_1_Exposure">Single UVB Overexposure Stimulates Melanocyte Proliferation in Murine Skin, in Contrast to Fractionated or UVA-1 Exposure</a></div><div class="wp-workCard_item"><span>Journal of Investigative Dermatology</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Overexposure to short-and long-wave ultraviolet radiations (UVB, UVA) may contribute to melanoma ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Overexposure to short-and long-wave ultraviolet radiations (UVB, UVA) may contribute to melanoma development through combined genotoxic and mitogenic effects in melanocytes. This study compares the impact of UVA-1 versus UVB, and single versus fractionated exposures on melanocyte proliferation in hairless SKH-2 mice. A single erythemal dose was compared with an equal dose fractionated over 8 d, and dose-dependency was studied. Proliferation (Ki-67 positive-sign) in melanocytes (melanoma antigen recognized by T-cells-1 positive or micropthalmia transcription factor positive) was ascertained in double-labeled skin sections. Single erythemal UVB exposures caused a delayed, dose-dependent increase of melanocyte proliferation. The highest, 17-fold, increase (from 0.05% to 0.8% of melanocytes) occurred 4 d after UVB exposure, without any detectable effect on overall melanocyte numbers. Correspondingly, DNA repair-deficient xeroderma pigmentosum A (Xpa) mice proved exquisitely sensitive to melanocyte proliferation induction by UVB exposure. No discernable effects were measured from fractionated suberythemal UVB exposures, or from any UVA-1 exposure regimen. Hence, melanocyte proliferation appears to be most efficiently induced by a single UVB overexposure. Moreover, the ineffectiveness of UVA-1 radiation and the enhanced sensitivity of Xpa mice point at pyrimidine dimers as causative DNA lesions. Consequently, murine nevi and melanoma are expected to be most effectively induced by intermittent UVB overexposures.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3f3391066ade74dc35659fb56a415feb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555432,"asset_id":110872770,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555432/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872770"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872770"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872770; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872770]").text(description); $(".js-view-count[data-work-id=110872770]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872770; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872770']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3f3391066ade74dc35659fb56a415feb" } } $('.js-work-strip[data-work-id=110872770]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872770,"title":"Single UVB Overexposure Stimulates Melanocyte Proliferation in Murine Skin, in Contrast to Fractionated or UVA-1 Exposure","internal_url":"https://www.academia.edu/110872770/Single_UVB_Overexposure_Stimulates_Melanocyte_Proliferation_in_Murine_Skin_in_Contrast_to_Fractionated_or_UVA_1_Exposure","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555432,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555432/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/108555432/download_file","bulk_download_file_name":"Single_UVB_Overexposure_Stimulates_Melan.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555432/pdf-libre.pdf?1702051109=\u0026response-content-disposition=attachment%3B+filename%3DSingle_UVB_Overexposure_Stimulates_Melan.pdf\u0026Expires=1739842295\u0026Signature=bkrk1Yx41CZEuGPE8iHjGBXcvN5VBBXW9ulzrbYVkbcGN2MECQm5JCCL5Q0x9JqZfOX2zAznAoo6vEujTmzPZ0PBNnHXkC6tDacUdTEa9OmDnE3wyQVa2ElAxNh0JxAEtV2Kk2VMxZAwKHYZkI~r~TG2rZtrKNJrimXBZHHo0aOtIRi3JSUvc5a6X6Lm2~wQ9dj6GAUO8ErQmfNcqkkgGh-71gBrr0Nrxi8vfBi~EPZKMyDzOBS3roy-sh1D8s7VWaTejxcAXRW8oqQ7YnzC45qffl5h5B7WrhoBSa9rrjQ0nbkDyNDUyAYtE7OzW~VxeapYsGGBrJSdPw-NTUF7gg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872769"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/110872769/UVB_can_affect_the_immune_system_resulting_in_decreased_resistance_to_infections_and_tumors"><img alt="Research paper thumbnail of UVB can affect the immune system resulting in decreased resistance to infections and tumors" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/110872769/UVB_can_affect_the_immune_system_resulting_in_decreased_resistance_to_infections_and_tumors">UVB can affect the immune system resulting in decreased resistance to infections and tumors</a></div><div class="wp-workCard_item"><span>Studies in Environmental Science</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract As a result of depletion of the ozone layer by industrial waste compounds, all living or...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract As a result of depletion of the ozone layer by industrial waste compounds, all living organisms on the earth&#39;s surface may be exposed to increased amounts of UVB radiation. In man UVB radiation can cause deleterious effects on the skin and the eyes. During the last years it has become clear that UVB can affect the immune system also. Hence, UVB may affect the resistance against infectious diseases. It is demonstrated that UVB can inhibit the immune response against skin-associated infectious diseases. However, recently it became clear that UVB can also induce immunosuppression at other loci than the exposed skin. Hence, also the immunological resistance against non-skin associated infectious diseases and tumors can be affected. Recently we demonstrated that low doses of UVB can induce immunosuppression in rodents and man. This suppression was not restricted to the exposed skin. Finally we demonstrated that this immunosuppression leads to a significant suppression of the resistance against non-skin associated infections in the rat. It is noteworthy that the resistance against bacterial (Listeria monocytogenes), viral (cytomegalo virus) as well as parasitic (Trichinella spiralis) infections was inhibited and that this inhibition was correlated to a suppression of the cellular immune system. Because these data demonstrate that low doses of UVB can affect the immune system in man and rodents and because animal studies showed that this immunosuppression inhibits the resistance to infections it is worthwile to analyse the risk for increased UVB levels with respect to infectious diseases in man.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872769"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872769"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872769; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872769]").text(description); $(".js-view-count[data-work-id=110872769]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872769; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872769']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=110872769]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872769,"title":"UVB can affect the immune system resulting in decreased resistance to infections and tumors","internal_url":"https://www.academia.edu/110872769/UVB_can_affect_the_immune_system_resulting_in_decreased_resistance_to_infections_and_tumors","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872768"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872768/Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types"><img alt="Research paper thumbnail of Concurrent health risks and benefits of low level sunlight exposure in different skin types" class="work-thumbnail" src="https://attachments.academia-assets.com/108555336/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872768/Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types">Concurrent health risks and benefits of low level sunlight exposure in different skin types</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1ae0749f15bc16327132ce2405d6d443" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555336,"asset_id":110872768,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555336/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872768"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872768"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872768; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872768]").text(description); $(".js-view-count[data-work-id=110872768]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872768; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872768']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1ae0749f15bc16327132ce2405d6d443" } } $('.js-work-strip[data-work-id=110872768]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872768,"title":"Concurrent health risks and benefits of low level sunlight exposure in different skin types","internal_url":"https://www.academia.edu/110872768/Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555336,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555336/thumbnails/1.jpg","file_name":"Rhodes_ESP_2017_Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types.do.pdf","download_url":"https://www.academia.edu/attachments/108555336/download_file","bulk_download_file_name":"Concurrent_health_risks_and_benefits_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555336/Rhodes_ESP_2017_Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types.do-libre.pdf?1702051110=\u0026response-content-disposition=attachment%3B+filename%3DConcurrent_health_risks_and_benefits_of.pdf\u0026Expires=1739842295\u0026Signature=GkvlC2aPtYL1wa0WiVCrbOL~kwIE4DiIvqP0aHiRGr31oI4yu7T5u40sFwMbDjNpngsR8n05SoTMLxo0~lHKe43ODaINIUtqlB9VrxYMB6uisViM8ewcnSMm8P6Dzsm5sME-wf9u7Oez2pi8Np4pjKVrYez5t6xHjxjau~1LKALDd9ktCb9bjqWwozW6pHz4mpzybm1ncY1pmCx9OLGNJqQMSc9G2i0UeVK5LjnpWUh0UR1EFpE3PBP62MFTRp8GSkJeaMJBOYUhnMLQzEUDB949XOGkYdujERcp5Gg9PcDNNGmVTJ08StYpb~EmyPeA2joXfrnlxyuLjqoOC3PhTg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":108555335,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555335/thumbnails/1.jpg","file_name":"Rhodes_ESP_2017_Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types.do.pdf","download_url":"https://www.academia.edu/attachments/108555335/download_file","bulk_download_file_name":"Concurrent_health_risks_and_benefits_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555335/Rhodes_ESP_2017_Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types.do-libre.pdf?1702051110=\u0026response-content-disposition=attachment%3B+filename%3DConcurrent_health_risks_and_benefits_of.pdf\u0026Expires=1739842295\u0026Signature=RhGZACkt8EaLbbvHMeKAErVjpaVYVaKw9rk6T7ykNEW7Sq2pFTnMhSOJCf1ALC22c7n9Uw243uWpmlskRk1ESsZ9QhT1NCjxFw5OaG3VbP~MMuw~WPJ-Mi~zqXmIWENVXZFp5FQIxHlAslAI-IdM3KzHgNMtfUq52EgYGN5Nqs1c1g4FRRAvOJbCVBYodaG2cbKPxOuu~iWF125QNynbgUPCQzviBiEUiYh-9snrWvOWdKLemNZkC6Ln9xSLD34TbqfyFbCxRbM4Z70jzxlzOHSHUHNpa8Y6dkghSrrNDJlYDuvG70jZ2nd1mJeiHsHd7RldfM5UaxT-ItKoDV77Jg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872766"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872766/Human_health_in_relation_to_exposure_to_solar_ultraviolet_radiation_under_changing_stratospheric_ozone_and_climate"><img alt="Research paper thumbnail of Human health in relation to exposure to solar ultraviolet radiation under changing stratospheric ozone and climate" class="work-thumbnail" src="https://attachments.academia-assets.com/108555334/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872766/Human_health_in_relation_to_exposure_to_solar_ultraviolet_radiation_under_changing_stratospheric_ozone_and_climate">Human health in relation to exposure to solar ultraviolet radiation under changing stratospheric ozone and climate</a></div><div class="wp-workCard_item"><span>Photochemical &amp; Photobiological Sciences</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The Montreal Protocol has limited increases in the UV-B (280–315 nm) radiation reaching the Earth...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The Montreal Protocol has limited increases in the UV-B (280–315 nm) radiation reaching the Earth&#39;s surface as a result of depletion of stratospheric ozone. Exposure to UV-B radiation has both risks and benefits for human health.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="81f50b263eb7568e6b2e9fa7f95159f1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555334,"asset_id":110872766,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555334/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872766"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872766"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872766; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872766]").text(description); $(".js-view-count[data-work-id=110872766]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872766; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872766']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "81f50b263eb7568e6b2e9fa7f95159f1" } } $('.js-work-strip[data-work-id=110872766]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872766,"title":"Human health in relation to exposure to solar ultraviolet radiation under changing stratospheric ozone and climate","internal_url":"https://www.academia.edu/110872766/Human_health_in_relation_to_exposure_to_solar_ultraviolet_radiation_under_changing_stratospheric_ozone_and_climate","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555334,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555334/thumbnails/1.jpg","file_name":"c8pp90060d.pdf","download_url":"https://www.academia.edu/attachments/108555334/download_file","bulk_download_file_name":"Human_health_in_relation_to_exposure_to.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555334/c8pp90060d-libre.pdf?1702051137=\u0026response-content-disposition=attachment%3B+filename%3DHuman_health_in_relation_to_exposure_to.pdf\u0026Expires=1739842295\u0026Signature=VpCkJ9G2B2pai3xWGN7wxnlqV5JDULZuClKDDJP-Hah5NSV1cUQEb8XdvxLtZix85DHYc-94AFwXsjz~HkoD-UhV0668aYqaQdFIAofykgXHewAdhmdYnLNvBYo2SwkV~puZsa1mESUnT4IYvnFSkwZzgbVgWrVk-pfkJUtlrf-h2KUCWOiWJ0TsusGGXVRZAYCfoV9E0G471JS7CPF9gdU15GshlCnoQmDeGTWVm7X6k9iq1VQoEUs3x2g~KJV7qGH-hckUIfd0okwIe7bfyQq1tx~jrkSfurRUenN1WVHwgQmuBKqnMaePLocR5pavTSOXY9OOI9oI5oZd4UqX5g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872765"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/110872765/Lgr5_and_Lgr6_epidermal_stem_cells_in_mouse_and_man"><img alt="Research paper thumbnail of Lgr5+ and Lgr6+ epidermal stem cells in mouse and man" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/110872765/Lgr5_and_Lgr6_epidermal_stem_cells_in_mouse_and_man">Lgr5+ and Lgr6+ epidermal stem cells in mouse and man</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dermatology-oncolog</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872765"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872765"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872765; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872765]").text(description); $(".js-view-count[data-work-id=110872765]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872765; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872765']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=110872765]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872765,"title":"Lgr5+ and Lgr6+ epidermal stem cells in mouse and man","internal_url":"https://www.academia.edu/110872765/Lgr5_and_Lgr6_epidermal_stem_cells_in_mouse_and_man","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872764"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872764/Early_p53_alterations_in_mouse_skin_carcinogenesis_by_UVB_radiation_immunohistochemical_detection_of_mutant_p53_protein_in_clusters_of_preneoplastic_epidermal_cells"><img alt="Research paper thumbnail of Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells" class="work-thumbnail" src="https://attachments.academia-assets.com/108555416/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872764/Early_p53_alterations_in_mouse_skin_carcinogenesis_by_UVB_radiation_immunohistochemical_detection_of_mutant_p53_protein_in_clusters_of_preneoplastic_epidermal_cells">Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells</a></div><div class="wp-workCard_item"><span>Proceedings of the National Academy of Sciences</span><span>, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">High levels of the p53 protein are immunohistochemically detectable in a majority of human nonmel...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">High levels of the p53 protein are immunohistochemically detectable in a majority of human nonmelanoma skin cancers and UVB-induced murine skin tumors. These increased protein levels are often associated with mutations in the conserved domains of the p53 gene. To investigate the timing of the p53 alterations in the process of UVB carcinogenesis, we used a well defined murine model (SKH:HR1 hairless mice) in which the time that tumors appear is predictable from the UVB exposures. The mice were subjected to a series of daily UVB exposures, either for 17 days or for 30 days, which would cause skin tumors to appear around 80 or 30 weeks, respectively. In the epidermis of these mice, we detected clusters of cells showing a strong immunostaining of the p53 protein, as measured with the CM-5 polyclonal antiserum. This cannot be explained by transient accumulation of the normal p53 protein as a physiological response to UVB-induced DNA damage. In single exposure experiments the observed tra...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dddf9e5d0a37df45fe2b0cbe63c85745" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555416,"asset_id":110872764,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555416/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872764"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872764"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872764; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872764]").text(description); $(".js-view-count[data-work-id=110872764]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872764; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872764']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dddf9e5d0a37df45fe2b0cbe63c85745" } } $('.js-work-strip[data-work-id=110872764]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872764,"title":"Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells","internal_url":"https://www.academia.edu/110872764/Early_p53_alterations_in_mouse_skin_carcinogenesis_by_UVB_radiation_immunohistochemical_detection_of_mutant_p53_protein_in_clusters_of_preneoplastic_epidermal_cells","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555416,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555416/thumbnails/1.jpg","file_name":"274.full.pdf","download_url":"https://www.academia.edu/attachments/108555416/download_file","bulk_download_file_name":"Early_p53_alterations_in_mouse_skin_carc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555416/274.full-libre.pdf?1702051109=\u0026response-content-disposition=attachment%3B+filename%3DEarly_p53_alterations_in_mouse_skin_carc.pdf\u0026Expires=1739842295\u0026Signature=I37rBoF4V0-M5WM3wT2bHDauyu9IpG9fOgIK4YUaDBk9hBwdLSFvAiyprBNBCIV0OolntoiQyoXkYWtpP~YFr1kNdiMmoOw1pmp55PbVNsKKxFwp86g214ODO-S0tzUVG-691FPdIbjOKa9T9j7gLGZOpPSpyPv9Et5MqaJMmAGa3Mq9eRdzks1ZlKr~7UEsvFix9QyMtHrci4C5IlEMdQanzL9bsueZSJckkSV6Yfa8un~oFY9ItDcjVjmTXrbN4pJpwKpygKzweDODOpxPKQLe5tJcGAzbAu3lp4f4kCGvawUmv4Wjqugqbif8ey-AJE8TUXdLvVsRmRAgZ3j~Rg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872763"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872763/Lifetime_prevalence_and_characteristics_of_photodermatoses_in_europe"><img alt="Research paper thumbnail of Lifetime prevalence and characteristics of photodermatoses in europe" class="work-thumbnail" src="https://attachments.academia-assets.com/108555415/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872763/Lifetime_prevalence_and_characteristics_of_photodermatoses_in_europe">Lifetime prevalence and characteristics of photodermatoses in europe</a></div><div class="wp-workCard_item"><span>Journal of Investigative Dermatology</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="200d91870dfc7c971889362b6d5d118d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555415,"asset_id":110872763,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555415/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872763"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872763"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872763; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872763]").text(description); $(".js-view-count[data-work-id=110872763]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872763; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872763']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "200d91870dfc7c971889362b6d5d118d" } } $('.js-work-strip[data-work-id=110872763]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872763,"title":"Lifetime prevalence and characteristics of photodermatoses in europe","internal_url":"https://www.academia.edu/110872763/Lifetime_prevalence_and_characteristics_of_photodermatoses_in_europe","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555415,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555415/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/108555415/download_file","bulk_download_file_name":"Lifetime_prevalence_and_characteristics.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555415/pdf-libre.pdf?1702051105=\u0026response-content-disposition=attachment%3B+filename%3DLifetime_prevalence_and_characteristics.pdf\u0026Expires=1739842295\u0026Signature=dZleVKQcv9GsySPqR9Z~HneZuQIXVqY4FSAe0gLXqPpSDTBRH9QPQHUL4d5Aoa~SDaNBdg83cKy8uFESs9-KNZpDENuYyczEKmAgR9XQ~LVgruoGkpzNep23LOB9huhZ7XV7biMyJ--ARKCYYJX7r3U2V8j0~--dM128wd-48FuRUWE8HBOpW~mgVD6t3Umjo-tJ99IqkiUBBQH32-MOjboxLF5zW9ngv6bUXuU89FI6LqvzMQYaxgG7BSnD6DfPrDQWagug3jAK2xmK4EFpZ2VF1UmVPEWodR4yFFMjrQsyV3Qr0kIcm7W3XYSU6J5cnKUgBUvKp2M51aTFfLlHQg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872762"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872762/Rapamycin_impairs_UV_induction_of_mutant_p53_overexpressing_cell_clusters_without_affecting_tumor_onset"><img alt="Research paper thumbnail of Rapamycin impairs UV induction of mutant‐p53 overexpressing cell clusters without affecting tumor onset" class="work-thumbnail" src="https://attachments.academia-assets.com/108555422/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872762/Rapamycin_impairs_UV_induction_of_mutant_p53_overexpressing_cell_clusters_without_affecting_tumor_onset">Rapamycin impairs UV induction of mutant‐p53 overexpressing cell clusters without affecting tumor onset</a></div><div class="wp-workCard_item"><span>International Journal of Cancer</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Because of its antitumor effect, the immunosuppressant rapamycin holds great promise for organ tr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Because of its antitumor effect, the immunosuppressant rapamycin holds great promise for organ transplant recipients in that it may lower their cancer risk. In a mouse model, we showed previously that rapamycin inhibits the outgrowth of primary skin carcinomas induced by UV radiation. However, the tumors that did grow out showed an altered p53 mutation spectrum. Here, we investigated whether this shift in p53 mutations already occurred in the smallest tumors, which were not affected in onset. We found that rapamycin did not alter the mutational spectrum in small tumors and in preceding microscopic clusters of cells expressing mutant‐p53. However, rapamycin did reduce the number of these cell clusters. As this reduction did not affect tumor onset, we subsequently investigated whether rapamycin merely suppressed expression of mutated p53. This was not the case, as we could demonstrate that switching from a diet with rapamycin to one without, or vice versa, did not affect the number of...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d16ec898809e40dea1cb631059edfeb1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555422,"asset_id":110872762,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555422/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872762"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872762"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872762; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872762]").text(description); $(".js-view-count[data-work-id=110872762]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872762; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872762']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d16ec898809e40dea1cb631059edfeb1" } } $('.js-work-strip[data-work-id=110872762]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872762,"title":"Rapamycin impairs UV induction of mutant‐p53 overexpressing cell clusters without affecting tumor onset","internal_url":"https://www.academia.edu/110872762/Rapamycin_impairs_UV_induction_of_mutant_p53_overexpressing_cell_clusters_without_affecting_tumor_onset","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555422,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555422/thumbnails/1.jpg","file_name":"ijc.2739120231208-1-bvrq9h.pdf","download_url":"https://www.academia.edu/attachments/108555422/download_file","bulk_download_file_name":"Rapamycin_impairs_UV_induction_of_mutant.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555422/ijc.2739120231208-1-bvrq9h-libre.pdf?1702051119=\u0026response-content-disposition=attachment%3B+filename%3DRapamycin_impairs_UV_induction_of_mutant.pdf\u0026Expires=1739842295\u0026Signature=RXIWhO3pBwzSTTEib1CYRBYR6wLt0Mp2EKfh-uardUbq5Fb6NJbXcZRxZt2p2fBW2wRobyFOJbfjeQCgvU0JHMyh9oqDRGHqzOtZ5u0OkGBygEzSZbfeG~71vl5G4zAEbHwwTfLsUGUdnQbXrL2E5G43vNHJ9N7J0bHTO7EP3fq-VrjFEMcxf7hBfgL45KB0VQ8FhD3-xaP28eAExbRBkr1hO8ERkG~Y6uKZWbJFhxBHZ-IoGfU3dkOb9QudaEyG21HArbHTgh8nuODvnSFDndmX~KUSyFI09JRUdNz~IvYsn-NKh8Uw5jzxRDGSjTIB5mmvYFSiDuBGMVdyjPJ9zg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872761"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872761/UV_induced_ablation_of_the_epidermal_basal_layer_including_p53_mutant_clones_resets_UV_carcinogenesis_showing_squamous_cell_carcinomas_to_originate_from_interfollicular_epidermis"><img alt="Research paper thumbnail of UV-induced ablation of the epidermal basal layer including p53-mutant clones resets UV carcinogenesis showing squamous cell carcinomas to originate from interfollicular epidermis" class="work-thumbnail" src="https://attachments.academia-assets.com/108555338/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872761/UV_induced_ablation_of_the_epidermal_basal_layer_including_p53_mutant_clones_resets_UV_carcinogenesis_showing_squamous_cell_carcinomas_to_originate_from_interfollicular_epidermis">UV-induced ablation of the epidermal basal layer including p53-mutant clones resets UV carcinogenesis showing squamous cell carcinomas to originate from interfollicular epidermis</a></div><div class="wp-workCard_item"><span>Carcinogenesis</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Chronic ultraviolet (UV) exposure induces clones of cells overexpressing mutant p53 in the interf...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Chronic ultraviolet (UV) exposure induces clones of cells overexpressing mutant p53 in the interfollicular (IF) epidermis and subsequently squamous cell carcinomas (SCCs) with similar p53 mutations. Mutated p53 may give cells growth advantage over neighbouring cells by impaired apoptosis. We tested this by UV overexposure of skin laden with p53-mutant clones and assessed the impact on subsequent tumour development. P53mutant clones were induced in two groups of hairless SKH1 mice by daily exposures (500 J/m 2 UV from TL12 lamps) for 28 days. On day 29, one group was overexposed (to 10 kJ/m 2 UV), whereas the control group received the regular daily dose. After 1 week of recovery, the daily exposures were resumed in both groups to induce SCCs. UV overexposure forced the entire IF basal layer into caspase-3-driven apoptosis while leaving overlying layers with sunburn cells intact. No apparent regions were spared from apoptosis. Pulse-chase BrdU labelling showed the IF epidermis to be repopulated from the hair follicles (remaining p63 positive). One week after overexposure, the p53-mutant clones had virtually disappeared (0.6, 95% confidence interval 0.5-0.8 per mouse versus 102, 59-179, without overexposure). Tumour development was significantly delayed after UV overexposure (P < 0.0001) by an average of 27 days (standard error of the mean 3); a period matching that of daily exposures preceding the overexposure. Thus, we found that UV-induced ablation of the IF epidermal basal layer eliminates p53-mutant clones and resets UV carcinogenesis. Furthermore, and in contrast with earlier reports, our data show that UV-induced p53-mutant clones and SCCs originate from the IF epidermis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cd53a74a9b98e36db639568124870e49" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555338,"asset_id":110872761,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555338/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872761"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872761"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872761; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872761]").text(description); $(".js-view-count[data-work-id=110872761]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872761; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872761']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cd53a74a9b98e36db639568124870e49" } } $('.js-work-strip[data-work-id=110872761]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872761,"title":"UV-induced ablation of the epidermal basal layer including p53-mutant clones resets UV carcinogenesis showing squamous cell carcinomas to originate from interfollicular epidermis","internal_url":"https://www.academia.edu/110872761/UV_induced_ablation_of_the_epidermal_basal_layer_including_p53_mutant_clones_resets_UV_carcinogenesis_showing_squamous_cell_carcinomas_to_originate_from_interfollicular_epidermis","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555338,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555338/thumbnails/1.jpg","file_name":"bgs004.pdf","download_url":"https://www.academia.edu/attachments/108555338/download_file","bulk_download_file_name":"UV_induced_ablation_of_the_epidermal_bas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555338/bgs004-libre.pdf?1702051111=\u0026response-content-disposition=attachment%3B+filename%3DUV_induced_ablation_of_the_epidermal_bas.pdf\u0026Expires=1739842295\u0026Signature=ACIMb-rnz7Ug98zo8rEeFyAmIDeTBpMvMta-xRCKbrEMYimbVefcwGZzz716-82qkOpdGdu~atn~qeP6iI3ALJ6Ti--nqTI7rR90k5eVrzL1iy6nJPePjS~P6pAyZlP7vIqE3VpzIKrZmMga4sz34Ey7Oh3YP1GAeDT4ZtkygyCTnK1Be-rvbUj~JpMIjpcxfzTQ~M8Dlq44J~6HZBSN7-TLZJd0vluuu0NJStFOLZlaO9fqLrxAb4DiHJOTQPKm-KScJ5yPnQuIQ2KlkDywBTWeyBxXNh31h6lhRZyY2GqeQf-~rv3s7uLHQJ-rughGacgk~XL3yh5fBXOQESnmqA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":108555337,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555337/thumbnails/1.jpg","file_name":"bgs004.pdf","download_url":"https://www.academia.edu/attachments/108555337/download_file","bulk_download_file_name":"UV_induced_ablation_of_the_epidermal_bas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555337/bgs004-libre.pdf?1702051117=\u0026response-content-disposition=attachment%3B+filename%3DUV_induced_ablation_of_the_epidermal_bas.pdf\u0026Expires=1739842295\u0026Signature=OfRv8pmoK1khpggzo2NWbDjXCK4-tGv6hkJG2~8evO0JMmjuLZuRwesuHq0r00u5YsrTl8NT9gCh0m1fiHGEXGj6lI67INo~7gsIoPLb8FnqWQHDYWBkvEGim1eGRUjrbWLwhK2m1D4MyvWy91klZHuEbbBUHJsqo1OoKt6omCznrZwRhvbf-UNA7oWLYYg4Ce6MYx8Cl9o8mF1ElU3io6cWKghE5OgInKaAgGBzzqCwOwUPRGdiNnUaamJzCH4dn60aR648Rstyla7Lw0Lvd0BC-n5yc5ZeWbyaSOMNxrbsDJubSu9kb0hOwacj7-1lmxidbxlqcCFBnqoT51lv0g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872554"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872554/Environmental_effects_of_ozone_depletion_and_its_interactions_with_climate_change_2002_assessment"><img alt="Research paper thumbnail of Environmental effects of ozone depletion and its interactions with climate change: 2002 assessment" class="work-thumbnail" src="https://attachments.academia-assets.com/108555193/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872554/Environmental_effects_of_ozone_depletion_and_its_interactions_with_climate_change_2002_assessment">Environmental effects of ozone depletion and its interactions with climate change: 2002 assessment</a></div><div class="wp-workCard_item"><span>Photochemical and Photobiological Sciences</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This quadrennial Assessment was prepared by the Environmental Effects Assessment Panel (EEAP) for...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This quadrennial Assessment was prepared by the Environmental Effects Assessment Panel (EEAP) for the Parties to the Montreal Protocol. The Assessment reports on key findings on environment and health since the last full Assessment of 2006, paying attention to the interactions between ozone depletion and climate change. Simultaneous publication of the Assessment in the scientific literature aims to inform the scientific community how their data, modeling and interpretations are playing a role in information dissemination to the Parties to the Montreal Protocol, other policymakers and scientists.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="636019843a29ca47b1005064011acfa3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555193,"asset_id":110872554,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555193/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872554"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872554"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872554; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872554]").text(description); $(".js-view-count[data-work-id=110872554]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872554; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872554']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "636019843a29ca47b1005064011acfa3" } } $('.js-work-strip[data-work-id=110872554]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872554,"title":"Environmental effects of ozone depletion and its interactions with climate change: 2002 assessment","internal_url":"https://www.academia.edu/110872554/Environmental_effects_of_ozone_depletion_and_its_interactions_with_climate_change_2002_assessment","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555193,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555193/thumbnails/1.jpg","file_name":"viewcontent.pdf","download_url":"https://www.academia.edu/attachments/108555193/download_file","bulk_download_file_name":"Environmental_effects_of_ozone_depletion.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555193/viewcontent-libre.pdf?1702054370=\u0026response-content-disposition=attachment%3B+filename%3DEnvironmental_effects_of_ozone_depletion.pdf\u0026Expires=1739842295\u0026Signature=NBAhBzgSV-Cbf76m96B~QN9O08-RYoAliwWm6bdAhbBgUlXYmq4v3mzHBCvrgMUL-6cvPeWRPe~-nCVIG0OCs1CbJ1FprTjysx-iOvGiovvsme9cKI1oNgl2XyUmnYeCmAnT-GVqiLPU2rjlXS-2nDZZgb~chTDxzM457l-R1K11xUNDj3a4kDxsWXB4uWZIdiy2fFDNzwPseCa4VjnuU7fQEjMeoMCLksVmmQwhU3gw1WdhBZf5ynie6lb-VPD24kRf1jsETja5A~KQUbm7YHSiYpIh~xlC91q67oOelakPjQoQvKNr5pUyaNKBsqQFB7QJVymPIS1wmiHShB10zQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":108555192,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555192/thumbnails/1.jpg","file_name":"viewcontent.pdf","download_url":"https://www.academia.edu/attachments/108555192/download_file","bulk_download_file_name":"Environmental_effects_of_ozone_depletion.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555192/viewcontent-libre.pdf?1702052963=\u0026response-content-disposition=attachment%3B+filename%3DEnvironmental_effects_of_ozone_depletion.pdf\u0026Expires=1739842295\u0026Signature=f5mxSzK7kfS6NRxvHz~pbMnZ2xf1T5cRvs2Ldo-DBhW9FzFvdgufm1TgDkxmXCfK1PRal4eDUhKNNN2FtxS1inhFtCqzUYEHnVv3K5t-Pjrba6E~-rbT4rgV6O-2wb3cVtf05c18XaKFQaOTNH48qwz6HMItIB-ecmH~zfqYNaEoOyKvJKGaFugdxlHfF3XpcLNES-B7IezFN~yCQoJwQ8oPl5zz~xpwJTRp5oEyX8bYSGtfIiCOqtJmAho1tVtbKg9Vw4RX6SQkgsE~FaM1-snxE8eRNJ9CS8tixeNK-z6OpC4K6Jl7wd75pw3pCB4T~QxiHRtYi~sac8qQ4t~v0Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79440649"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/79440649/Climate_change_and_human_skin_cancer"><img alt="Research paper thumbnail of Climate change and human skin cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/79440649/Climate_change_and_human_skin_cancer">Climate change and human skin cancer</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FGruijl">Frank De Gruijl</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://ifir.academia.edu/Rub%C3%A9nDPiacentini">Rubén D Piacentini</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FrankGruijl">Frank Gruijl</a></span></div><div class="wp-workCard_item"><span>Photochemical & Photobiological Sciences</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79440649"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79440649"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79440649; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79440649]").text(description); $(".js-view-count[data-work-id=79440649]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79440649; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79440649']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=79440649]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79440649,"title":"Climate change and human skin cancer","internal_url":"https://www.academia.edu/79440649/Climate_change_and_human_skin_cancer","owner_id":622973,"coauthors_can_edit":true,"owner":{"id":622973,"first_name":"Rubén D","middle_initials":"","last_name":"Piacentini","page_name":"RubénDPiacentini","domain_name":"ifir","created_at":"2011-07-29T02:13:02.660-07:00","display_name":"Rubén D Piacentini","url":"https://ifir.academia.edu/Rub%C3%A9nDPiacentini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103885677"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103885677/Repeat_UVA_exposure_of_human_skin_fibroblasts_induces_both_a_transitionary_and_recovery_DNA_methylation_response"><img alt="Research paper thumbnail of Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response" class="work-thumbnail" src="https://attachments.academia-assets.com/103766942/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103885677/Repeat_UVA_exposure_of_human_skin_fibroblasts_induces_both_a_transitionary_and_recovery_DNA_methylation_response">Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response</a></div><div class="wp-workCard_item"><span>Epigenomics</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim: UVA radiation drives skin photoaging in the dermis, plausibly via persistent changes to DNA ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim: UVA radiation drives skin photoaging in the dermis, plausibly via persistent changes to DNA methylation in dermal fibroblasts. Methods: Genome-wide DNA methylation changes after five repeated daily UVA doses were determined at 48 h (transitionary) and 1 week (recovery) post final irradiation. Results: Differential methylation was found at the transitionary time point in active chromatin states near genes that are highly expressed in fibroblasts and are involved in cellular defensive mechanisms; the majority of these methylation differences were restored to control levels after 7 day recovery. At the recovery time point, new differential methylation occurred at repressed regions near developmental genes, normally weakly expressed in fibroblasts. Conclusion: UVA irradiation induces transitionary and recovery-associated DNA methylation responses in fibroblasts with contrasting functional characteristics.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ca35be1f17b530adcd075e7d1a54347e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103766942,"asset_id":103885677,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103766942/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103885677"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103885677"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103885677; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103885677]").text(description); $(".js-view-count[data-work-id=103885677]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103885677; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103885677']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ca35be1f17b530adcd075e7d1a54347e" } } $('.js-work-strip[data-work-id=103885677]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103885677,"title":"Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response","internal_url":"https://www.academia.edu/103885677/Repeat_UVA_exposure_of_human_skin_fibroblasts_induces_both_a_transitionary_and_recovery_DNA_methylation_response","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":103766942,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/103766942/thumbnails/1.jpg","file_name":"epi-2019-025120230626-1-yg2xy9.pdf","download_url":"https://www.academia.edu/attachments/103766942/download_file","bulk_download_file_name":"Repeat_UVA_exposure_of_human_skin_fibrob.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/103766942/epi-2019-025120230626-1-yg2xy9-libre.pdf?1687779672=\u0026response-content-disposition=attachment%3B+filename%3DRepeat_UVA_exposure_of_human_skin_fibrob.pdf\u0026Expires=1739842295\u0026Signature=G1Uq7-Umqnv8wcazTBPD9jakYieBqj-GcsnOlbRAS8YBOpKs6HagvsS8iAJvNUFy2WGaoZ6PpD9VhgXpnq9mL8J5WGvzGO4S5ZmgsijU0vbhSw0nZ0X-DuZHEkVdPOqxdsHr59fkuXOlFN2XrVyNfsTyoFkC1bD8YmYxhSKFlU-1M3y35w~fK5LjaFkAqKmKUazYuoDkOeztjCm2bNcAbmmQoe-hP-vAGS~0CONJBmPcJAOd-V968DlIGhp9jugH9JIUklwApRdLbtHJc1OtDwYhNWhpSIDUmM73N0G~uA5fgfY3dwe17eK~tvkexaB-pLWrZ3iyLnaRX8wqydZr3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3586240" id="papers"><div class="js-work-strip profile--work_container" data-work-id="110872782"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872782/Ultraviolet_Radiation_Induced_Impairment_of_the_Early_Initiating_and_the_Late_Effector_Phases_of_Contact_Hypersensitivity_to_Picrylcholoride_Regulation_by_Different_Mechanisms"><img alt="Research paper thumbnail of Ultraviolet Radiation-Induced Impairment of the Early Initiating and the Late Effector Phases of Contact Hypersensitivity to Picrylcholoride: Regulation by Different Mechanisms" class="work-thumbnail" src="https://attachments.academia-assets.com/108555426/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872782/Ultraviolet_Radiation_Induced_Impairment_of_the_Early_Initiating_and_the_Late_Effector_Phases_of_Contact_Hypersensitivity_to_Picrylcholoride_Regulation_by_Different_Mechanisms">Ultraviolet Radiation-Induced Impairment of the Early Initiating and the Late Effector Phases of Contact Hypersensitivity to Picrylcholoride: Regulation by Different Mechanisms</a></div><div class="wp-workCard_item"><span>Journal of Investigative Dermatology</span><span>, Jun 1, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">'fwo types of antigen-specific T cells are needed for the elicitation of contact hypersensitivity...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">'fwo types of antigen-specific T cells are needed for the elicitation of contact hypersensitivity reactions. They act in an obligate sequence to mediate the early initiating and late effector phases of contact hypersensitivity, which are accompanied by skin-swelling responses at 2 and 24 h after challenge, respectively. The magnitude of the late ear swelling depends on that of the early swelling. We studied the influence of ultraviolet radiation on both phases of contact hypersensitivity to picrylchloride. Mice were exposed to subedemal doses of ultraviolet radiation on the shaved backs for four consecutive days. Four days later mice were sensitized on non-irradiated skin. Four days after sensitization mice were challenged on the ears, and swelling was measured 2, 4, and 24 h after challenge. The early and T he immunosuppressive properties of ultraviolet radiation (UVR) have been known for several years. Studies of Fisher and Kripke [1,2] and of Spellman et af [3] showed in inbred mice that the UVR-induced suppression of rejection of highly antigenic, UVR-induced tumors is transferable with lymphoid cells. UVR also suppresses delayed-type hypersensitivity (DTH) to a variety of antigens such as haptens [4,5], allogeneic sfleen cells [6,7], viruses [S], bacteria [9], fungi [10] , and parasites 11]. DTH assays are convenient assays to study the mechanisms of UVR-induced suppression of cellular immunity because they are relatively easy to perform. In the above-mentioned studies, the suppression of the "classical" DTH reaction, measurable as a skin-swelling reaction that peaks 24-4S h after antigen challenge, was investigated. However, Van Loveren and colleagues reported that elicitation of murine DTH reactions is dependent on the sequential activities of at least two different antigen-specific Thy-1+, CDS+, CDS-cells [12,13]. These two different T cells medii\te separate ea rly and late steps in the DTH reaction that are accompanied by maximum skin swellings at 2 and 24 h after challenge lI2-1S]. More recently the phenotype of these cells was more extensively characterized [14]. The early DTH-initiating cell , which has recently been cloned [16], is Manuscript</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bf84d81c5cbeb0a163d30fd13b607874" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555426,"asset_id":110872782,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555426/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872782"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872782"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872782; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872782]").text(description); $(".js-view-count[data-work-id=110872782]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872782; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872782']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "bf84d81c5cbeb0a163d30fd13b607874" } } $('.js-work-strip[data-work-id=110872782]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872782,"title":"Ultraviolet Radiation-Induced Impairment of the Early Initiating and the Late Effector Phases of Contact Hypersensitivity to Picrylcholoride: Regulation by Different Mechanisms","internal_url":"https://www.academia.edu/110872782/Ultraviolet_Radiation_Induced_Impairment_of_the_Early_Initiating_and_the_Late_Effector_Phases_of_Contact_Hypersensitivity_to_Picrylcholoride_Regulation_by_Different_Mechanisms","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555426,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555426/thumbnails/1.jpg","file_name":"82733693.pdf","download_url":"https://www.academia.edu/attachments/108555426/download_file","bulk_download_file_name":"Ultraviolet_Radiation_Induced_Impairment.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555426/82733693-libre.pdf?1702051123=\u0026response-content-disposition=attachment%3B+filename%3DUltraviolet_Radiation_Induced_Impairment.pdf\u0026Expires=1739842295\u0026Signature=WshsnuG7HrLJPuscohM1cAEDXgcfEQCQPP9aztSaE-cPAASIcBitJzfan-P-sMvnJlUAj03OlM2K2yzbydVtOJd9iIAoNGKYv9AnG5ry5HmwcF6OD3Wts6AsEdqwFGEz8v39bqT2Jzsc0j57DHxWEw0u8QZxH1BNooXXWHkq~sjZdhi4npk412aAwef29Hfc2rNcSR12MKNM6xltjR6XLTOsS-BIPEAEWbzqSBHVo4a4W6UtaDasOFcWKkYa1pbMUeQO5bwC12i3qCFF05DkGLgp-0h7NBQLZgMCZmyehiGXpEOwwDnxZoD9oVme0sYHksdnzGJ9JVHs8CzGkwqXOw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872781"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872781/Mismatch_repair_protein_Msh2_contributes_to_UVB_induced_cell_cycle_arrest_in_epidermal_and_cultured_mouse_keratinocytes"><img alt="Research paper thumbnail of Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes" class="work-thumbnail" src="https://attachments.academia-assets.com/108555427/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872781/Mismatch_repair_protein_Msh2_contributes_to_UVB_induced_cell_cycle_arrest_in_epidermal_and_cultured_mouse_keratinocytes">Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes</a></div><div class="wp-workCard_item"><span>DNA Repair</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Nucleotide excision repair (NER), cell cycle regulation and apoptosis are major defence mechanism...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Nucleotide excision repair (NER), cell cycle regulation and apoptosis are major defence mechanisms against the carcinogenic effects of UVB radiation. NER eliminates UVB-induced DNA photolesions via two subpathways: global genome repair (GGR) and transcription-coupled repair (TCR). In a previous study, we found UVB-induced accumulation of tetraploid (4N) keratinocytes in the epidermis of Xpc −/− mice (no GGR), but not in Xpa −/− (no TCR and no GGR) or in wild-type (WT) mice. We inferred that this arrest in Xpc −/− mice is caused by erroneous replication past photolesions, leading to 'compound lesions' known to be recognised by mismatch repair (MMR). MMR-induced futile cycles of breakage and resynthesis at sites of compound lesions may then sustain a cell cycle arrest. The present experiments with Xpc −/− Msh2 −/− mice and derived keratinocytes show that the MMR protein Msh2 indeed plays a role in the generation of the UVB-induced arrested cells: a Msh2-deficiency lowered significantly the percentage of arrested cells in vivo (40-50%) and in vitro (30-40%). Analysis of calyculin A (CA)-induced premature chromosome condensation (PCC) of cultured Xpc −/− keratinocytes showed that the delayed arrest occurred in late S phase rather than in G 2-phase. Taken together, the results indicate that in mouse epidermis and cultured keratinocytes, the MMR protein Msh2 plays a role in the UVB-induced S-phase arrest. This indicates that MMR plays a role in the UVB-induced S-phase arrest. Alternatively, Msh2 may have a more direct signalling function.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="39a757b73fb6b4ca56a653762a738e4f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555427,"asset_id":110872781,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555427/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872781"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872781"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872781; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872781]").text(description); $(".js-view-count[data-work-id=110872781]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872781; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872781']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "39a757b73fb6b4ca56a653762a738e4f" } } $('.js-work-strip[data-work-id=110872781]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872781,"title":"Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes","internal_url":"https://www.academia.edu/110872781/Mismatch_repair_protein_Msh2_contributes_to_UVB_induced_cell_cycle_arrest_in_epidermal_and_cultured_mouse_keratinocytes","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555427,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555427/thumbnails/1.jpg","file_name":"j.dnarep.2004.08.00820231208-1-97xcx6.pdf","download_url":"https://www.academia.edu/attachments/108555427/download_file","bulk_download_file_name":"Mismatch_repair_protein_Msh2_contributes.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555427/j.dnarep.2004.08.00820231208-1-97xcx6-libre.pdf?1702051106=\u0026response-content-disposition=attachment%3B+filename%3DMismatch_repair_protein_Msh2_contributes.pdf\u0026Expires=1739842295\u0026Signature=Ztqbak3Mw3roveyR~hwLUyo~GmVit4yZRGYRKUDPBD2lTlfF2mA9muKUMRAs9oDTm0mzNyn0gKBBNxpB6q1PMFevBET6WWNYSXxsh2mAXa~wwQa8O~hVK6FzBHQZ76Kiq7fIkGZXnvSUXw0P9xc4r5o7bxiOhI1jwclFqmoYQL95D7NOlGpYwnW0iTBWSXjSXtzrhIc6OfUKqwvFd8kd8WDo0q5ymDS93awJizcdTfXsYtwWCQK0c46Pdf7c3Rvi2kP9ViDO6jNBt4WXeDBulpYNQyIcM3qocSsBP88WYUeSpvATnYMqrSBbsHhMPwR6UyOFdm9vweoO1MMmq~zeRA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872780"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872780/Effects_of_Ultraviolet_B_Exposure_on_the_Resistance_to_Listeria_monocytogenes_in_the_Rat"><img alt="Research paper thumbnail of Effects of Ultraviolet-B Exposure on the Resistance to Listeria monocytogenes in the Rat" class="work-thumbnail" src="https://attachments.academia-assets.com/108555433/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872780/Effects_of_Ultraviolet_B_Exposure_on_the_Resistance_to_Listeria_monocytogenes_in_the_Rat">Effects of Ultraviolet-B Exposure on the Resistance to Listeria monocytogenes in the Rat</a></div><div class="wp-workCard_item"><span>Photochemistry and Photobiology</span><span>, May 1, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A rat infection model using the bacterial pathogen Listeria monocytogenes was employed to analyze...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A rat infection model using the bacterial pathogen Listeria monocytogenes was employed to analyze the immunosuppressive activity of UVB radiation. Rats were exposed to suberythemal doses of UVB radiation for 5 or 7 consecutive days, using Kromayer or FS40 lamps respectively. Subsequently, the rats were infected subcutaneously or intravenously with Listeria. Exposure to UVB resulted in an increased number of bacteria in the spleen 4 days after infection. Listeria-specific lymphocyte proliferation assays as well as delayed-type hypersensitivity reactions demonstrated that T cell-mediated immunity to Listeria was impaired by UVB as measured 4 and 8 days after infection. In addition, UVB exposure decreased phagocytotic activity of peripheral blood macrophages. This study demonstrated that suberythemal doses of UVB radiation caused a delay in the clearance of Listeria bacteria from the spleen of the rats and that this was probably caused by impaired nonspecific phagocytosis of Listeria by macrophages in addition to an impaired activity of Listeria-specific T cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ba8a47f821ae3ed8fe6d4ec09409ed1a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555433,"asset_id":110872780,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555433/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872780"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872780"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872780; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872780]").text(description); $(".js-view-count[data-work-id=110872780]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872780; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872780']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ba8a47f821ae3ed8fe6d4ec09409ed1a" } } $('.js-work-strip[data-work-id=110872780]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872780,"title":"Effects of Ultraviolet-B Exposure on the Resistance to Listeria monocytogenes in the Rat","internal_url":"https://www.academia.edu/110872780/Effects_of_Ultraviolet_B_Exposure_on_the_Resistance_to_Listeria_monocytogenes_in_the_Rat","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555433,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555433/thumbnails/1.jpg","file_name":"j.1751-1097.1996.tb05672.x20231208-1-lpizfa.pdf","download_url":"https://www.academia.edu/attachments/108555433/download_file","bulk_download_file_name":"Effects_of_Ultraviolet_B_Exposure_on_the.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555433/j.1751-1097.1996.tb05672.x20231208-1-lpizfa-libre.pdf?1702051107=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Ultraviolet_B_Exposure_on_the.pdf\u0026Expires=1739842295\u0026Signature=a3vTAPRHItJkqmbBlfTuMHFKUUtnFTGrMluNy-lzZiGmd-toQxqOUoKkeBS-rkslWyUaLVqQBXoznh7318cEBJMZBioLsdnEUxr7QAqm19eSA0kQYfKn6e2wc4qUb9hwm8y11K~NdIDlLnZ3PR3OmKkH5tHKZetIoWVd5yuAvJrhEALu-9PDnkUaR0U3rW4aZ76JUUdsV-hGUg1e1YvHoO6lnWuk-LNoj8i4xYePl5raomZFJ9TkLe74J14ZRkxkE0aFZDcpUzJtnewjw23ZO~AEBPRbiIw9vtwNjFVBFeZDNje0WBB6nG8Y0zv0Lo0jTgYbs0-wmiOCzQ0Xt9txLA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872779"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872779/Epidermal_cis_Urocanic_Acid_Levels_Correlate_with_Lower_Specific_Cellular_Immune_Responses_After_Hepatitis_B_Vaccination_of_Ultraviolet_B_exposed_Humans_"><img alt="Research paper thumbnail of Epidermal cis-Urocanic Acid Levels Correlate with Lower Specific Cellular Immune Responses After Hepatitis B Vaccination of Ultraviolet B-exposed Humans¶" class="work-thumbnail" src="https://attachments.academia-assets.com/108555424/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872779/Epidermal_cis_Urocanic_Acid_Levels_Correlate_with_Lower_Specific_Cellular_Immune_Responses_After_Hepatitis_B_Vaccination_of_Ultraviolet_B_exposed_Humans_">Epidermal cis-Urocanic Acid Levels Correlate with Lower Specific Cellular Immune Responses After Hepatitis B Vaccination of Ultraviolet B-exposed Humans¶</a></div><div class="wp-workCard_item"><span>Photochemistry and Photobiology</span><span>, May 1, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Urocanic acid (UCA) is a major UV-absorbing chromophore in the epidermis and has been suggested t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Urocanic acid (UCA) is a major UV-absorbing chromophore in the epidermis and has been suggested to act as one of the initiators of UV-induced immunosuppression. cis-UCA, the isomer from UCA that is formed upon UV exposure, has been shown to impair some cellular immune responses. cis-UCA levels were determined in a study in which the influence of ultraviolet B (UVB) exposure on immune responses after hepatitis B vaccination in human volunteers was established. A significant increase in cis-UCA levels was found in the skin of UVB-exposed volunteers compared with controls. cis-UCA levels, calculated as the percentage of the total UCA amount, in UVB-exposed volunteers correlated significantly with the cumulative UVB dose received in 5 consecutive days, i.e. the higher the UVB dose (J/m 2), the higher the cis-UCA levels (until a cis-UCA plateau was reached in the so-called photostationary state). Correlations between skin cis-UCA levels and immune responses were determined, and they revealed no statistically significant correlations among lymphocyte proliferation responses after either mitogenic stimulation or stimulation with recall antigens. No correlation was found between cis-UCA levels and hepatitis B-specific antibody titers. However, we found a statistically significant negative correlation between cis-UCA levels and hepatitis Bspecific lymphocyte proliferation responses when volunteers were irradiated with UVB before hepatitis B vaccination. In other words, volunteers with high cis-UCA levels caused by UVB exposure showed lower cellular immune responses against hepatitis B antigen after hepatitis B vaccination.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b8e2923538d36267a9c53ef028378ee5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555424,"asset_id":110872779,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555424/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872779"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872779"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872779; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872779]").text(description); $(".js-view-count[data-work-id=110872779]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872779; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872779']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b8e2923538d36267a9c53ef028378ee5" } } $('.js-work-strip[data-work-id=110872779]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872779,"title":"Epidermal cis-Urocanic Acid Levels Correlate with Lower Specific Cellular Immune Responses After Hepatitis B Vaccination of Ultraviolet B-exposed Humans¶","internal_url":"https://www.academia.edu/110872779/Epidermal_cis_Urocanic_Acid_Levels_Correlate_with_Lower_Specific_Cellular_Immune_Responses_After_Hepatitis_B_Vaccination_of_Ultraviolet_B_exposed_Humans_","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555424,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555424/thumbnails/1.jpg","file_name":"0031-8655282003290770271ecualc2.0.co220231208-1-wjwmjv.pdf","download_url":"https://www.academia.edu/attachments/108555424/download_file","bulk_download_file_name":"Epidermal_cis_Urocanic_Acid_Levels_Corre.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555424/0031-8655282003290770271ecualc2.0.co220231208-1-wjwmjv-libre.pdf?1702051105=\u0026response-content-disposition=attachment%3B+filename%3DEpidermal_cis_Urocanic_Acid_Levels_Corre.pdf\u0026Expires=1739842295\u0026Signature=Bm6koTS1mPpPzj1C58wlGIrfUwpQPmiMGBRErkoWe3XSB-UHLHvhoA5bcauEpyywA7D1xvdod2flop0Vteow6pbtToS7EJH18R6ajIwo~2nP3m32dG7ZH~0V45T70f3894TVcktre5qCtdwJV2EZB3d3z71tWAWT7YrQkLttOm6pVuocINX38vf0RdcMyKkUTFs3TBsfVe0XIUgBtQETekgn0k4bRHyog16jirSiIcIlYvC2YYf-uJbOGw-PrtkbFS6gMMY6hQeRcXGYgCeXa-AHRj0SP1eO8w6D1J9Qcygj7I2HRWpPAtRT38fhymfKwRuPtUYnW7ke~yK17JwyEA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872778"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872778/UVB_Exposure_Impairs_Immune_Responses_After_Hepatitis_B_Vaccination_in_Two_Different_Mouse_Strains_"><img alt="Research paper thumbnail of UVB Exposure Impairs Immune Responses After Hepatitis B Vaccination in Two Different Mouse Strains¶" class="work-thumbnail" src="https://attachments.academia-assets.com/108555449/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872778/UVB_Exposure_Impairs_Immune_Responses_After_Hepatitis_B_Vaccination_in_Two_Different_Mouse_Strains_">UVB Exposure Impairs Immune Responses After Hepatitis B Vaccination in Two Different Mouse Strains¶</a></div><div class="wp-workCard_item"><span>Photochemistry and Photobiology</span><span>, May 1, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Ultraviolet light exposure can impair immune responses that are not restricted to the exposed ski...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Ultraviolet light exposure can impair immune responses that are not restricted to the exposed skin but is also found at other sites, i.e. systemic immunosuppression. Therefore, we investigated the UV-induced modulating effects on vaccination against hepatitis B in a mouse model. Two different mouse strains, BALB/c and C57Bl/ 6, were vaccinated intramuscularly against hepatitis B. Mice were exposed to different doses of ultraviolet B (UVB) for five consecutive days on shaved back skin before the vaccination. Vaccination against hepatitis B induced cellular (delayed-type hypersensitivity [DTH] and lymphocyte stimulation test) as well as humoral immune responses in both mouse strains. The DTH responses in C57Bl/6 mice were statistically significantly higher compared with BALB/c mice. UVB exposure induced a dosedependent suppression of cellular immunity in both strains of mice. C57Bl/6 mice seemed to be more susceptible to this suppression. Anti-hepatitis B surface antibodies (total-Ig) were only marginally suppressed after UVB exposure. IgG2a and interferon-␥ levels, both indicators for Th1 immune response, were suppressed in both mouse strains after UVB exposure. In summary, UVB exposure induced a dose-dependent suppression of both cellular and humoral immune responses after hep-¶Posted on the web site on</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3a04ee0ac3612cda0deb7340b4edc5be" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555449,"asset_id":110872778,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555449/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872778"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872778"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872778; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872778]").text(description); $(".js-view-count[data-work-id=110872778]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872778; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872778']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3a04ee0ac3612cda0deb7340b4edc5be" } } $('.js-work-strip[data-work-id=110872778]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872778,"title":"UVB Exposure Impairs Immune Responses After Hepatitis B Vaccination in Two Different Mouse Strains¶","internal_url":"https://www.academia.edu/110872778/UVB_Exposure_Impairs_Immune_Responses_After_Hepatitis_B_Vaccination_in_Two_Different_Mouse_Strains_","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555449,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555449/thumbnails/1.jpg","file_name":"0031-8655282002290750541ueiira2.0.co220231208-1-2kb29d.pdf","download_url":"https://www.academia.edu/attachments/108555449/download_file","bulk_download_file_name":"UVB_Exposure_Impairs_Immune_Responses_Af.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555449/0031-8655282002290750541ueiira2.0.co220231208-1-2kb29d-libre.pdf?1702051108=\u0026response-content-disposition=attachment%3B+filename%3DUVB_Exposure_Impairs_Immune_Responses_Af.pdf\u0026Expires=1739842295\u0026Signature=UUFPcFtN~7tVX-JC8eehYhIwSvpqS~nzOt1C0caZVqh9DC~Baz114oCCxacYwOALBPoISeGNcDSprWX7c7-9Qh1-dwLKK8NmeuI9sKhkjgQNZRyqWz4CchJmBvNlbOZXT1ZPc4cThrKr1cDzdM-4SYmtslXOpeZsyfYrr9l9-uEm5YCLUNNFCRfIccSr0RCxnyiazqxGH6xKa37l0f3kULneBwqlGA~DQpAcMB7ev2N~DPzUQ0vihSeRC7mjOIFXrpsIoijZQxUrOPcNUZMEtY~Fk~yguLZFhKooJnnFYiMELwyX7Q8ZnKKFDFwopnFQUsqbNSEYQ8oq7bc7zW3xkg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872777"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872777/Association_of_Transcription_Coupled_Repair_but_Not_Global_Genome_Repair_with_Ultraviolet_B_Induced_Langerhans_Cell_Depletion_and_Local_Immunosuppression"><img alt="Research paper thumbnail of Association of Transcription-Coupled Repair but Not Global Genome Repair with Ultraviolet-B-Induced Langerhans Cell Depletion and Local Immunosuppression" class="work-thumbnail" src="https://attachments.academia-assets.com/108555343/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872777/Association_of_Transcription_Coupled_Repair_but_Not_Global_Genome_Repair_with_Ultraviolet_B_Induced_Langerhans_Cell_Depletion_and_Local_Immunosuppression">Association of Transcription-Coupled Repair but Not Global Genome Repair with Ultraviolet-B-Induced Langerhans Cell Depletion and Local Immunosuppression</a></div><div class="wp-workCard_item"><span>Journal of Investigative Dermatology</span><span>, Oct 1, 2003</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="583fc2e3353413c44263f97bb0962848" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555343,"asset_id":110872777,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555343/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872777"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872777"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872777; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872777]").text(description); $(".js-view-count[data-work-id=110872777]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872777; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872777']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "583fc2e3353413c44263f97bb0962848" } } $('.js-work-strip[data-work-id=110872777]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872777,"title":"Association of Transcription-Coupled Repair but Not Global Genome Repair with Ultraviolet-B-Induced Langerhans Cell Depletion and Local Immunosuppression","internal_url":"https://www.academia.edu/110872777/Association_of_Transcription_Coupled_Repair_but_Not_Global_Genome_Repair_with_Ultraviolet_B_Induced_Langerhans_Cell_Depletion_and_Local_Immunosuppression","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555343,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555343/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/108555343/download_file","bulk_download_file_name":"Association_of_Transcription_Coupled_Rep.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555343/pdf-libre.pdf?1702051115=\u0026response-content-disposition=attachment%3B+filename%3DAssociation_of_Transcription_Coupled_Rep.pdf\u0026Expires=1739842295\u0026Signature=hJIc0aZAu3NszLj4m3Xj77e~r9nUghBYAXCrgSogs3vbFaFJxQ3wasccyunkSwg0svyxUgbPDQJ2O~7Pcrdcz5gD3A9fiq~XcVOzoSTDC33HP2kukMv7VkczsfBlrsgjY5qPCbF0R6lB3G0SqIGemjzS4pGOdEKM9Mb~d200HyMLQOul5xbgtnLYvERo6jypSRxiVt1rLh--oQ4AdCIhd~WgAx2QjzUCAnpKmLZ0XwV94sca-52WRY-OHDpbQVHSLqcC28SFm1bXX2h6THPvkZjuprkuvxcAqUbvt28rezR37xOZVuHj-uX7dSDv0ffeUY-yS0q8OyiBDDUabTkBWw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":108555342,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555342/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/108555342/download_file","bulk_download_file_name":"Association_of_Transcription_Coupled_Rep.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555342/pdf-libre.pdf?1702051115=\u0026response-content-disposition=attachment%3B+filename%3DAssociation_of_Transcription_Coupled_Rep.pdf\u0026Expires=1739842295\u0026Signature=BAsNOIwTdqAq8QO5IESLQZnQwJOpqNt3rxx6F6AMzZv1GysGU9ULNaxuclafU~rWGyCjslGwVdXq7MNEYM2ZCNXIQsWu9IwWDpROO5Pzf2NVPtAbW4bntdzcWoWfarKOk~FNyc8QAAWia0jURrsXwI-QLj1xdTeoeIsQnNmovMHg0fnk5vG6mYM0~t~24jvsxRvFy5RHzl5Ev0dCYvSnVNMieMDMzlw2qHk9ptE7eZEiDPrv3Pdn36jexPB7nzOl0O112hhZnnHrbHHhVzSr2Fo-~GYX7GsNSx8LBoe6N55TmgIxnSSVTQHvfC8~XQhmQwegyX5NZfi~lgBIK2rj3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872773"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872773/Supplementary_Table_1_Figures_1_4_from_Dietary_Immunosuppressants_Do_Not_Enhance_UV_Induced_Skin_Carcinogenesis_and_Reveal_Discordance_between_p53_Mutant_Early_Clones_and_Carcinomas"><img alt="Research paper thumbnail of Supplementary Table 1, Figures 1 - 4 from Dietary Immunosuppressants Do Not Enhance UV-Induced Skin Carcinogenesis, and Reveal Discordance between p53-Mutant Early Clones and Carcinomas" class="work-thumbnail" src="https://attachments.academia-assets.com/108555425/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872773/Supplementary_Table_1_Figures_1_4_from_Dietary_Immunosuppressants_Do_Not_Enhance_UV_Induced_Skin_Carcinogenesis_and_Reveal_Discordance_between_p53_Mutant_Early_Clones_and_Carcinomas">Supplementary Table 1, Figures 1 - 4 from Dietary Immunosuppressants Do Not Enhance UV-Induced Skin Carcinogenesis, and Reveal Discordance between p53-Mutant Early Clones and Carcinomas</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Supplementary figure 1; Effects of immunosuppressive drugs on epidermal proliferation in HSEs (n=...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Supplementary figure 1; Effects of immunosuppressive drugs on epidermal proliferation in HSEs (n=3-4) as % of Ki-67 positive (supra-)basal cells. ANOVA shows only Rapa to differ from control (p<0.05). Results for two concentrations of immunosuppressants are combined. Error bars depict SEM.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d1f07092edbbb10d3925ee089fa0b8e0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555425,"asset_id":110872773,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555425/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872773"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872773"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872773; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872773]").text(description); $(".js-view-count[data-work-id=110872773]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872773; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872773']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d1f07092edbbb10d3925ee089fa0b8e0" } } $('.js-work-strip[data-work-id=110872773]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872773,"title":"Supplementary Table 1, Figures 1 - 4 from Dietary Immunosuppressants Do Not Enhance UV-Induced Skin Carcinogenesis, and Reveal Discordance between p53-Mutant Early Clones and Carcinomas","internal_url":"https://www.academia.edu/110872773/Supplementary_Table_1_Figures_1_4_from_Dietary_Immunosuppressants_Do_Not_Enhance_UV_Induced_Skin_Carcinogenesis_and_Reveal_Discordance_between_p53_Mutant_Early_Clones_and_Carcinomas","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555425,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555425/thumbnails/1.jpg","file_name":"19406207capr120361-sup-capr-12-0361tab1fig1-4.pdf","download_url":"https://www.academia.edu/attachments/108555425/download_file","bulk_download_file_name":"Supplementary_Table_1_Figures_1_4_from_D.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555425/19406207capr120361-sup-capr-12-0361tab1fig1-4-libre.pdf?1702051104=\u0026response-content-disposition=attachment%3B+filename%3DSupplementary_Table_1_Figures_1_4_from_D.pdf\u0026Expires=1739842295\u0026Signature=MEgQ9Rx1851-1uM1-Q-AvJBRHBtes-sBVxL5Kyzi-LICfOEkbD1x7UPm8T1UjnzZiTJO3RpK~4JaoduQxjIpIwrQzMclQgd4Zz1HLeMADRz4KlcEX-kMBFe~bWMN34iPvNie7vZ3-89H7RH2Af6S4RQPEJAW0I4~jN3v~bRH9~P~ucvxeyw9N5EzcXIZJzyEvKNuRf4MgYTHoJvNHN02ZCqdJdscChgIpdljf7Bvu7jP6AddAyW~tEc9xZHaA4IAI2PAy6vr2WoxmWve9m-ZND5ueOHwadamzbUIdk3vLyXKRiMBW5vqc2~EPnZAgQFLrylXaQpg~Ah4nOSsstUChg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872772"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872772/Risk_assessment_of_UVB_effects_on_resistance_to_infectious_diseases"><img alt="Research paper thumbnail of Risk assessment of UVB effects on resistance to infectious diseases" class="work-thumbnail" src="https://attachments.academia-assets.com/108555423/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872772/Risk_assessment_of_UVB_effects_on_resistance_to_infectious_diseases">Risk assessment of UVB effects on resistance to infectious diseases</a></div><div class="wp-workCard_item"><span>Toxicology Letters</span><span>, Aug 1, 1995</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="03c226294c34ea0c1bc9f91c24d3f04f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555423,"asset_id":110872772,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555423/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872772"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872772"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872772; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872772]").text(description); $(".js-view-count[data-work-id=110872772]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872772; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872772']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "03c226294c34ea0c1bc9f91c24d3f04f" } } $('.js-work-strip[data-work-id=110872772]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872772,"title":"Risk assessment of UVB effects on resistance to infectious diseases","internal_url":"https://www.academia.edu/110872772/Risk_assessment_of_UVB_effects_on_resistance_to_infectious_diseases","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555423,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555423/thumbnails/1.jpg","file_name":"03784-27492859294639X-20231208-1-368azp.pdf","download_url":"https://www.academia.edu/attachments/108555423/download_file","bulk_download_file_name":"Risk_assessment_of_UVB_effects_on_resist.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555423/03784-27492859294639X-20231208-1-368azp-libre.pdf?1702051105=\u0026response-content-disposition=attachment%3B+filename%3DRisk_assessment_of_UVB_effects_on_resist.pdf\u0026Expires=1739842295\u0026Signature=Pp4bCaakOSqScj3blkWAvV64OxyxjspuuJZJlHvEvLTBanEHXM3EbL~mcn5iu25DMDVURWZa9H88Pkv6b88oQVx0u1MvVK31xQi5mzWEhz5ZOp1eEUqcWRdnDmTj6wwfYf1PeYF5swk10sS7pti6wkvJAyGjgyMIb-4FeF4Lgi1ZfOJ1-WwOMFwRiNifYa-CpKYLPISLxF9YX2wSwrHGSIbYZSKs9VpIXBth3ZASFay2Hd61HFVjvjzqs5fXM2aFuUSKcxVvBpxd1gSLdk6UOnvEMh94F2MbQmG3am8-7x6fk2oVhutsyjwf37DrrFCHTfHdfQ9V7TI4y~5QjSDPqw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872770"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872770/Single_UVB_Overexposure_Stimulates_Melanocyte_Proliferation_in_Murine_Skin_in_Contrast_to_Fractionated_or_UVA_1_Exposure"><img alt="Research paper thumbnail of Single UVB Overexposure Stimulates Melanocyte Proliferation in Murine Skin, in Contrast to Fractionated or UVA-1 Exposure" class="work-thumbnail" src="https://attachments.academia-assets.com/108555432/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872770/Single_UVB_Overexposure_Stimulates_Melanocyte_Proliferation_in_Murine_Skin_in_Contrast_to_Fractionated_or_UVA_1_Exposure">Single UVB Overexposure Stimulates Melanocyte Proliferation in Murine Skin, in Contrast to Fractionated or UVA-1 Exposure</a></div><div class="wp-workCard_item"><span>Journal of Investigative Dermatology</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Overexposure to short-and long-wave ultraviolet radiations (UVB, UVA) may contribute to melanoma ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Overexposure to short-and long-wave ultraviolet radiations (UVB, UVA) may contribute to melanoma development through combined genotoxic and mitogenic effects in melanocytes. This study compares the impact of UVA-1 versus UVB, and single versus fractionated exposures on melanocyte proliferation in hairless SKH-2 mice. A single erythemal dose was compared with an equal dose fractionated over 8 d, and dose-dependency was studied. Proliferation (Ki-67 positive-sign) in melanocytes (melanoma antigen recognized by T-cells-1 positive or micropthalmia transcription factor positive) was ascertained in double-labeled skin sections. Single erythemal UVB exposures caused a delayed, dose-dependent increase of melanocyte proliferation. The highest, 17-fold, increase (from 0.05% to 0.8% of melanocytes) occurred 4 d after UVB exposure, without any detectable effect on overall melanocyte numbers. Correspondingly, DNA repair-deficient xeroderma pigmentosum A (Xpa) mice proved exquisitely sensitive to melanocyte proliferation induction by UVB exposure. No discernable effects were measured from fractionated suberythemal UVB exposures, or from any UVA-1 exposure regimen. Hence, melanocyte proliferation appears to be most efficiently induced by a single UVB overexposure. Moreover, the ineffectiveness of UVA-1 radiation and the enhanced sensitivity of Xpa mice point at pyrimidine dimers as causative DNA lesions. Consequently, murine nevi and melanoma are expected to be most effectively induced by intermittent UVB overexposures.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="3f3391066ade74dc35659fb56a415feb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555432,"asset_id":110872770,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555432/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872770"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872770"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872770; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872770]").text(description); $(".js-view-count[data-work-id=110872770]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872770; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872770']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "3f3391066ade74dc35659fb56a415feb" } } $('.js-work-strip[data-work-id=110872770]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872770,"title":"Single UVB Overexposure Stimulates Melanocyte Proliferation in Murine Skin, in Contrast to Fractionated or UVA-1 Exposure","internal_url":"https://www.academia.edu/110872770/Single_UVB_Overexposure_Stimulates_Melanocyte_Proliferation_in_Murine_Skin_in_Contrast_to_Fractionated_or_UVA_1_Exposure","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555432,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555432/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/108555432/download_file","bulk_download_file_name":"Single_UVB_Overexposure_Stimulates_Melan.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555432/pdf-libre.pdf?1702051109=\u0026response-content-disposition=attachment%3B+filename%3DSingle_UVB_Overexposure_Stimulates_Melan.pdf\u0026Expires=1739842295\u0026Signature=bkrk1Yx41CZEuGPE8iHjGBXcvN5VBBXW9ulzrbYVkbcGN2MECQm5JCCL5Q0x9JqZfOX2zAznAoo6vEujTmzPZ0PBNnHXkC6tDacUdTEa9OmDnE3wyQVa2ElAxNh0JxAEtV2Kk2VMxZAwKHYZkI~r~TG2rZtrKNJrimXBZHHo0aOtIRi3JSUvc5a6X6Lm2~wQ9dj6GAUO8ErQmfNcqkkgGh-71gBrr0Nrxi8vfBi~EPZKMyDzOBS3roy-sh1D8s7VWaTejxcAXRW8oqQ7YnzC45qffl5h5B7WrhoBSa9rrjQ0nbkDyNDUyAYtE7OzW~VxeapYsGGBrJSdPw-NTUF7gg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872769"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/110872769/UVB_can_affect_the_immune_system_resulting_in_decreased_resistance_to_infections_and_tumors"><img alt="Research paper thumbnail of UVB can affect the immune system resulting in decreased resistance to infections and tumors" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/110872769/UVB_can_affect_the_immune_system_resulting_in_decreased_resistance_to_infections_and_tumors">UVB can affect the immune system resulting in decreased resistance to infections and tumors</a></div><div class="wp-workCard_item"><span>Studies in Environmental Science</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abstract As a result of depletion of the ozone layer by industrial waste compounds, all living or...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abstract As a result of depletion of the ozone layer by industrial waste compounds, all living organisms on the earth&#39;s surface may be exposed to increased amounts of UVB radiation. In man UVB radiation can cause deleterious effects on the skin and the eyes. During the last years it has become clear that UVB can affect the immune system also. Hence, UVB may affect the resistance against infectious diseases. It is demonstrated that UVB can inhibit the immune response against skin-associated infectious diseases. However, recently it became clear that UVB can also induce immunosuppression at other loci than the exposed skin. Hence, also the immunological resistance against non-skin associated infectious diseases and tumors can be affected. Recently we demonstrated that low doses of UVB can induce immunosuppression in rodents and man. This suppression was not restricted to the exposed skin. Finally we demonstrated that this immunosuppression leads to a significant suppression of the resistance against non-skin associated infections in the rat. It is noteworthy that the resistance against bacterial (Listeria monocytogenes), viral (cytomegalo virus) as well as parasitic (Trichinella spiralis) infections was inhibited and that this inhibition was correlated to a suppression of the cellular immune system. Because these data demonstrate that low doses of UVB can affect the immune system in man and rodents and because animal studies showed that this immunosuppression inhibits the resistance to infections it is worthwile to analyse the risk for increased UVB levels with respect to infectious diseases in man.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872769"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872769"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872769; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872769]").text(description); $(".js-view-count[data-work-id=110872769]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872769; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872769']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=110872769]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872769,"title":"UVB can affect the immune system resulting in decreased resistance to infections and tumors","internal_url":"https://www.academia.edu/110872769/UVB_can_affect_the_immune_system_resulting_in_decreased_resistance_to_infections_and_tumors","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872768"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872768/Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types"><img alt="Research paper thumbnail of Concurrent health risks and benefits of low level sunlight exposure in different skin types" class="work-thumbnail" src="https://attachments.academia-assets.com/108555336/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872768/Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types">Concurrent health risks and benefits of low level sunlight exposure in different skin types</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1ae0749f15bc16327132ce2405d6d443" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555336,"asset_id":110872768,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555336/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872768"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872768"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872768; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872768]").text(description); $(".js-view-count[data-work-id=110872768]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872768; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872768']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1ae0749f15bc16327132ce2405d6d443" } } $('.js-work-strip[data-work-id=110872768]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872768,"title":"Concurrent health risks and benefits of low level sunlight exposure in different skin types","internal_url":"https://www.academia.edu/110872768/Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555336,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555336/thumbnails/1.jpg","file_name":"Rhodes_ESP_2017_Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types.do.pdf","download_url":"https://www.academia.edu/attachments/108555336/download_file","bulk_download_file_name":"Concurrent_health_risks_and_benefits_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555336/Rhodes_ESP_2017_Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types.do-libre.pdf?1702051110=\u0026response-content-disposition=attachment%3B+filename%3DConcurrent_health_risks_and_benefits_of.pdf\u0026Expires=1739842295\u0026Signature=GkvlC2aPtYL1wa0WiVCrbOL~kwIE4DiIvqP0aHiRGr31oI4yu7T5u40sFwMbDjNpngsR8n05SoTMLxo0~lHKe43ODaINIUtqlB9VrxYMB6uisViM8ewcnSMm8P6Dzsm5sME-wf9u7Oez2pi8Np4pjKVrYez5t6xHjxjau~1LKALDd9ktCb9bjqWwozW6pHz4mpzybm1ncY1pmCx9OLGNJqQMSc9G2i0UeVK5LjnpWUh0UR1EFpE3PBP62MFTRp8GSkJeaMJBOYUhnMLQzEUDB949XOGkYdujERcp5Gg9PcDNNGmVTJ08StYpb~EmyPeA2joXfrnlxyuLjqoOC3PhTg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":108555335,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555335/thumbnails/1.jpg","file_name":"Rhodes_ESP_2017_Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types.do.pdf","download_url":"https://www.academia.edu/attachments/108555335/download_file","bulk_download_file_name":"Concurrent_health_risks_and_benefits_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555335/Rhodes_ESP_2017_Concurrent_health_risks_and_benefits_of_low_level_sunlight_exposure_in_different_skin_types.do-libre.pdf?1702051110=\u0026response-content-disposition=attachment%3B+filename%3DConcurrent_health_risks_and_benefits_of.pdf\u0026Expires=1739842295\u0026Signature=RhGZACkt8EaLbbvHMeKAErVjpaVYVaKw9rk6T7ykNEW7Sq2pFTnMhSOJCf1ALC22c7n9Uw243uWpmlskRk1ESsZ9QhT1NCjxFw5OaG3VbP~MMuw~WPJ-Mi~zqXmIWENVXZFp5FQIxHlAslAI-IdM3KzHgNMtfUq52EgYGN5Nqs1c1g4FRRAvOJbCVBYodaG2cbKPxOuu~iWF125QNynbgUPCQzviBiEUiYh-9snrWvOWdKLemNZkC6Ln9xSLD34TbqfyFbCxRbM4Z70jzxlzOHSHUHNpa8Y6dkghSrrNDJlYDuvG70jZ2nd1mJeiHsHd7RldfM5UaxT-ItKoDV77Jg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872766"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872766/Human_health_in_relation_to_exposure_to_solar_ultraviolet_radiation_under_changing_stratospheric_ozone_and_climate"><img alt="Research paper thumbnail of Human health in relation to exposure to solar ultraviolet radiation under changing stratospheric ozone and climate" class="work-thumbnail" src="https://attachments.academia-assets.com/108555334/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872766/Human_health_in_relation_to_exposure_to_solar_ultraviolet_radiation_under_changing_stratospheric_ozone_and_climate">Human health in relation to exposure to solar ultraviolet radiation under changing stratospheric ozone and climate</a></div><div class="wp-workCard_item"><span>Photochemical &amp; Photobiological Sciences</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The Montreal Protocol has limited increases in the UV-B (280–315 nm) radiation reaching the Earth...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The Montreal Protocol has limited increases in the UV-B (280–315 nm) radiation reaching the Earth&#39;s surface as a result of depletion of stratospheric ozone. Exposure to UV-B radiation has both risks and benefits for human health.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="81f50b263eb7568e6b2e9fa7f95159f1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555334,"asset_id":110872766,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555334/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872766"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872766"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872766; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872766]").text(description); $(".js-view-count[data-work-id=110872766]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872766; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872766']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "81f50b263eb7568e6b2e9fa7f95159f1" } } $('.js-work-strip[data-work-id=110872766]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872766,"title":"Human health in relation to exposure to solar ultraviolet radiation under changing stratospheric ozone and climate","internal_url":"https://www.academia.edu/110872766/Human_health_in_relation_to_exposure_to_solar_ultraviolet_radiation_under_changing_stratospheric_ozone_and_climate","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555334,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555334/thumbnails/1.jpg","file_name":"c8pp90060d.pdf","download_url":"https://www.academia.edu/attachments/108555334/download_file","bulk_download_file_name":"Human_health_in_relation_to_exposure_to.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555334/c8pp90060d-libre.pdf?1702051137=\u0026response-content-disposition=attachment%3B+filename%3DHuman_health_in_relation_to_exposure_to.pdf\u0026Expires=1739842295\u0026Signature=VpCkJ9G2B2pai3xWGN7wxnlqV5JDULZuClKDDJP-Hah5NSV1cUQEb8XdvxLtZix85DHYc-94AFwXsjz~HkoD-UhV0668aYqaQdFIAofykgXHewAdhmdYnLNvBYo2SwkV~puZsa1mESUnT4IYvnFSkwZzgbVgWrVk-pfkJUtlrf-h2KUCWOiWJ0TsusGGXVRZAYCfoV9E0G471JS7CPF9gdU15GshlCnoQmDeGTWVm7X6k9iq1VQoEUs3x2g~KJV7qGH-hckUIfd0okwIe7bfyQq1tx~jrkSfurRUenN1WVHwgQmuBKqnMaePLocR5pavTSOXY9OOI9oI5oZd4UqX5g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872765"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/110872765/Lgr5_and_Lgr6_epidermal_stem_cells_in_mouse_and_man"><img alt="Research paper thumbnail of Lgr5+ and Lgr6+ epidermal stem cells in mouse and man" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/110872765/Lgr5_and_Lgr6_epidermal_stem_cells_in_mouse_and_man">Lgr5+ and Lgr6+ epidermal stem cells in mouse and man</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dermatology-oncolog</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872765"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872765"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872765; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872765]").text(description); $(".js-view-count[data-work-id=110872765]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872765; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872765']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=110872765]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872765,"title":"Lgr5+ and Lgr6+ epidermal stem cells in mouse and man","internal_url":"https://www.academia.edu/110872765/Lgr5_and_Lgr6_epidermal_stem_cells_in_mouse_and_man","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872764"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872764/Early_p53_alterations_in_mouse_skin_carcinogenesis_by_UVB_radiation_immunohistochemical_detection_of_mutant_p53_protein_in_clusters_of_preneoplastic_epidermal_cells"><img alt="Research paper thumbnail of Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells" class="work-thumbnail" src="https://attachments.academia-assets.com/108555416/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872764/Early_p53_alterations_in_mouse_skin_carcinogenesis_by_UVB_radiation_immunohistochemical_detection_of_mutant_p53_protein_in_clusters_of_preneoplastic_epidermal_cells">Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells</a></div><div class="wp-workCard_item"><span>Proceedings of the National Academy of Sciences</span><span>, 1996</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">High levels of the p53 protein are immunohistochemically detectable in a majority of human nonmel...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">High levels of the p53 protein are immunohistochemically detectable in a majority of human nonmelanoma skin cancers and UVB-induced murine skin tumors. These increased protein levels are often associated with mutations in the conserved domains of the p53 gene. To investigate the timing of the p53 alterations in the process of UVB carcinogenesis, we used a well defined murine model (SKH:HR1 hairless mice) in which the time that tumors appear is predictable from the UVB exposures. The mice were subjected to a series of daily UVB exposures, either for 17 days or for 30 days, which would cause skin tumors to appear around 80 or 30 weeks, respectively. In the epidermis of these mice, we detected clusters of cells showing a strong immunostaining of the p53 protein, as measured with the CM-5 polyclonal antiserum. This cannot be explained by transient accumulation of the normal p53 protein as a physiological response to UVB-induced DNA damage. In single exposure experiments the observed tra...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="dddf9e5d0a37df45fe2b0cbe63c85745" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555416,"asset_id":110872764,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555416/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872764"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872764"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872764; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872764]").text(description); $(".js-view-count[data-work-id=110872764]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872764; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872764']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "dddf9e5d0a37df45fe2b0cbe63c85745" } } $('.js-work-strip[data-work-id=110872764]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872764,"title":"Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells","internal_url":"https://www.academia.edu/110872764/Early_p53_alterations_in_mouse_skin_carcinogenesis_by_UVB_radiation_immunohistochemical_detection_of_mutant_p53_protein_in_clusters_of_preneoplastic_epidermal_cells","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555416,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555416/thumbnails/1.jpg","file_name":"274.full.pdf","download_url":"https://www.academia.edu/attachments/108555416/download_file","bulk_download_file_name":"Early_p53_alterations_in_mouse_skin_carc.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555416/274.full-libre.pdf?1702051109=\u0026response-content-disposition=attachment%3B+filename%3DEarly_p53_alterations_in_mouse_skin_carc.pdf\u0026Expires=1739842295\u0026Signature=I37rBoF4V0-M5WM3wT2bHDauyu9IpG9fOgIK4YUaDBk9hBwdLSFvAiyprBNBCIV0OolntoiQyoXkYWtpP~YFr1kNdiMmoOw1pmp55PbVNsKKxFwp86g214ODO-S0tzUVG-691FPdIbjOKa9T9j7gLGZOpPSpyPv9Et5MqaJMmAGa3Mq9eRdzks1ZlKr~7UEsvFix9QyMtHrci4C5IlEMdQanzL9bsueZSJckkSV6Yfa8un~oFY9ItDcjVjmTXrbN4pJpwKpygKzweDODOpxPKQLe5tJcGAzbAu3lp4f4kCGvawUmv4Wjqugqbif8ey-AJE8TUXdLvVsRmRAgZ3j~Rg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872763"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872763/Lifetime_prevalence_and_characteristics_of_photodermatoses_in_europe"><img alt="Research paper thumbnail of Lifetime prevalence and characteristics of photodermatoses in europe" class="work-thumbnail" src="https://attachments.academia-assets.com/108555415/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872763/Lifetime_prevalence_and_characteristics_of_photodermatoses_in_europe">Lifetime prevalence and characteristics of photodermatoses in europe</a></div><div class="wp-workCard_item"><span>Journal of Investigative Dermatology</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="200d91870dfc7c971889362b6d5d118d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555415,"asset_id":110872763,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555415/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872763"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872763"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872763; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872763]").text(description); $(".js-view-count[data-work-id=110872763]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872763; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872763']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "200d91870dfc7c971889362b6d5d118d" } } $('.js-work-strip[data-work-id=110872763]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872763,"title":"Lifetime prevalence and characteristics of photodermatoses in europe","internal_url":"https://www.academia.edu/110872763/Lifetime_prevalence_and_characteristics_of_photodermatoses_in_europe","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555415,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555415/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/108555415/download_file","bulk_download_file_name":"Lifetime_prevalence_and_characteristics.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555415/pdf-libre.pdf?1702051105=\u0026response-content-disposition=attachment%3B+filename%3DLifetime_prevalence_and_characteristics.pdf\u0026Expires=1739842295\u0026Signature=dZleVKQcv9GsySPqR9Z~HneZuQIXVqY4FSAe0gLXqPpSDTBRH9QPQHUL4d5Aoa~SDaNBdg83cKy8uFESs9-KNZpDENuYyczEKmAgR9XQ~LVgruoGkpzNep23LOB9huhZ7XV7biMyJ--ARKCYYJX7r3U2V8j0~--dM128wd-48FuRUWE8HBOpW~mgVD6t3Umjo-tJ99IqkiUBBQH32-MOjboxLF5zW9ngv6bUXuU89FI6LqvzMQYaxgG7BSnD6DfPrDQWagug3jAK2xmK4EFpZ2VF1UmVPEWodR4yFFMjrQsyV3Qr0kIcm7W3XYSU6J5cnKUgBUvKp2M51aTFfLlHQg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872762"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872762/Rapamycin_impairs_UV_induction_of_mutant_p53_overexpressing_cell_clusters_without_affecting_tumor_onset"><img alt="Research paper thumbnail of Rapamycin impairs UV induction of mutant‐p53 overexpressing cell clusters without affecting tumor onset" class="work-thumbnail" src="https://attachments.academia-assets.com/108555422/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872762/Rapamycin_impairs_UV_induction_of_mutant_p53_overexpressing_cell_clusters_without_affecting_tumor_onset">Rapamycin impairs UV induction of mutant‐p53 overexpressing cell clusters without affecting tumor onset</a></div><div class="wp-workCard_item"><span>International Journal of Cancer</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Because of its antitumor effect, the immunosuppressant rapamycin holds great promise for organ tr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Because of its antitumor effect, the immunosuppressant rapamycin holds great promise for organ transplant recipients in that it may lower their cancer risk. In a mouse model, we showed previously that rapamycin inhibits the outgrowth of primary skin carcinomas induced by UV radiation. However, the tumors that did grow out showed an altered p53 mutation spectrum. Here, we investigated whether this shift in p53 mutations already occurred in the smallest tumors, which were not affected in onset. We found that rapamycin did not alter the mutational spectrum in small tumors and in preceding microscopic clusters of cells expressing mutant‐p53. However, rapamycin did reduce the number of these cell clusters. As this reduction did not affect tumor onset, we subsequently investigated whether rapamycin merely suppressed expression of mutated p53. This was not the case, as we could demonstrate that switching from a diet with rapamycin to one without, or vice versa, did not affect the number of...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d16ec898809e40dea1cb631059edfeb1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555422,"asset_id":110872762,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555422/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872762"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872762"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872762; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872762]").text(description); $(".js-view-count[data-work-id=110872762]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872762; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872762']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d16ec898809e40dea1cb631059edfeb1" } } $('.js-work-strip[data-work-id=110872762]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872762,"title":"Rapamycin impairs UV induction of mutant‐p53 overexpressing cell clusters without affecting tumor onset","internal_url":"https://www.academia.edu/110872762/Rapamycin_impairs_UV_induction_of_mutant_p53_overexpressing_cell_clusters_without_affecting_tumor_onset","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555422,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555422/thumbnails/1.jpg","file_name":"ijc.2739120231208-1-bvrq9h.pdf","download_url":"https://www.academia.edu/attachments/108555422/download_file","bulk_download_file_name":"Rapamycin_impairs_UV_induction_of_mutant.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555422/ijc.2739120231208-1-bvrq9h-libre.pdf?1702051119=\u0026response-content-disposition=attachment%3B+filename%3DRapamycin_impairs_UV_induction_of_mutant.pdf\u0026Expires=1739842295\u0026Signature=RXIWhO3pBwzSTTEib1CYRBYR6wLt0Mp2EKfh-uardUbq5Fb6NJbXcZRxZt2p2fBW2wRobyFOJbfjeQCgvU0JHMyh9oqDRGHqzOtZ5u0OkGBygEzSZbfeG~71vl5G4zAEbHwwTfLsUGUdnQbXrL2E5G43vNHJ9N7J0bHTO7EP3fq-VrjFEMcxf7hBfgL45KB0VQ8FhD3-xaP28eAExbRBkr1hO8ERkG~Y6uKZWbJFhxBHZ-IoGfU3dkOb9QudaEyG21HArbHTgh8nuODvnSFDndmX~KUSyFI09JRUdNz~IvYsn-NKh8Uw5jzxRDGSjTIB5mmvYFSiDuBGMVdyjPJ9zg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872761"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872761/UV_induced_ablation_of_the_epidermal_basal_layer_including_p53_mutant_clones_resets_UV_carcinogenesis_showing_squamous_cell_carcinomas_to_originate_from_interfollicular_epidermis"><img alt="Research paper thumbnail of UV-induced ablation of the epidermal basal layer including p53-mutant clones resets UV carcinogenesis showing squamous cell carcinomas to originate from interfollicular epidermis" class="work-thumbnail" src="https://attachments.academia-assets.com/108555338/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872761/UV_induced_ablation_of_the_epidermal_basal_layer_including_p53_mutant_clones_resets_UV_carcinogenesis_showing_squamous_cell_carcinomas_to_originate_from_interfollicular_epidermis">UV-induced ablation of the epidermal basal layer including p53-mutant clones resets UV carcinogenesis showing squamous cell carcinomas to originate from interfollicular epidermis</a></div><div class="wp-workCard_item"><span>Carcinogenesis</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Chronic ultraviolet (UV) exposure induces clones of cells overexpressing mutant p53 in the interf...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Chronic ultraviolet (UV) exposure induces clones of cells overexpressing mutant p53 in the interfollicular (IF) epidermis and subsequently squamous cell carcinomas (SCCs) with similar p53 mutations. Mutated p53 may give cells growth advantage over neighbouring cells by impaired apoptosis. We tested this by UV overexposure of skin laden with p53-mutant clones and assessed the impact on subsequent tumour development. P53mutant clones were induced in two groups of hairless SKH1 mice by daily exposures (500 J/m 2 UV from TL12 lamps) for 28 days. On day 29, one group was overexposed (to 10 kJ/m 2 UV), whereas the control group received the regular daily dose. After 1 week of recovery, the daily exposures were resumed in both groups to induce SCCs. UV overexposure forced the entire IF basal layer into caspase-3-driven apoptosis while leaving overlying layers with sunburn cells intact. No apparent regions were spared from apoptosis. Pulse-chase BrdU labelling showed the IF epidermis to be repopulated from the hair follicles (remaining p63 positive). One week after overexposure, the p53-mutant clones had virtually disappeared (0.6, 95% confidence interval 0.5-0.8 per mouse versus 102, 59-179, without overexposure). Tumour development was significantly delayed after UV overexposure (P < 0.0001) by an average of 27 days (standard error of the mean 3); a period matching that of daily exposures preceding the overexposure. Thus, we found that UV-induced ablation of the IF epidermal basal layer eliminates p53-mutant clones and resets UV carcinogenesis. Furthermore, and in contrast with earlier reports, our data show that UV-induced p53-mutant clones and SCCs originate from the IF epidermis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cd53a74a9b98e36db639568124870e49" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555338,"asset_id":110872761,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555338/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872761"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872761"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872761; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872761]").text(description); $(".js-view-count[data-work-id=110872761]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872761; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872761']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cd53a74a9b98e36db639568124870e49" } } $('.js-work-strip[data-work-id=110872761]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872761,"title":"UV-induced ablation of the epidermal basal layer including p53-mutant clones resets UV carcinogenesis showing squamous cell carcinomas to originate from interfollicular epidermis","internal_url":"https://www.academia.edu/110872761/UV_induced_ablation_of_the_epidermal_basal_layer_including_p53_mutant_clones_resets_UV_carcinogenesis_showing_squamous_cell_carcinomas_to_originate_from_interfollicular_epidermis","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555338,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555338/thumbnails/1.jpg","file_name":"bgs004.pdf","download_url":"https://www.academia.edu/attachments/108555338/download_file","bulk_download_file_name":"UV_induced_ablation_of_the_epidermal_bas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555338/bgs004-libre.pdf?1702051111=\u0026response-content-disposition=attachment%3B+filename%3DUV_induced_ablation_of_the_epidermal_bas.pdf\u0026Expires=1739842295\u0026Signature=ACIMb-rnz7Ug98zo8rEeFyAmIDeTBpMvMta-xRCKbrEMYimbVefcwGZzz716-82qkOpdGdu~atn~qeP6iI3ALJ6Ti--nqTI7rR90k5eVrzL1iy6nJPePjS~P6pAyZlP7vIqE3VpzIKrZmMga4sz34Ey7Oh3YP1GAeDT4ZtkygyCTnK1Be-rvbUj~JpMIjpcxfzTQ~M8Dlq44J~6HZBSN7-TLZJd0vluuu0NJStFOLZlaO9fqLrxAb4DiHJOTQPKm-KScJ5yPnQuIQ2KlkDywBTWeyBxXNh31h6lhRZyY2GqeQf-~rv3s7uLHQJ-rughGacgk~XL3yh5fBXOQESnmqA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":108555337,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555337/thumbnails/1.jpg","file_name":"bgs004.pdf","download_url":"https://www.academia.edu/attachments/108555337/download_file","bulk_download_file_name":"UV_induced_ablation_of_the_epidermal_bas.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555337/bgs004-libre.pdf?1702051117=\u0026response-content-disposition=attachment%3B+filename%3DUV_induced_ablation_of_the_epidermal_bas.pdf\u0026Expires=1739842295\u0026Signature=OfRv8pmoK1khpggzo2NWbDjXCK4-tGv6hkJG2~8evO0JMmjuLZuRwesuHq0r00u5YsrTl8NT9gCh0m1fiHGEXGj6lI67INo~7gsIoPLb8FnqWQHDYWBkvEGim1eGRUjrbWLwhK2m1D4MyvWy91klZHuEbbBUHJsqo1OoKt6omCznrZwRhvbf-UNA7oWLYYg4Ce6MYx8Cl9o8mF1ElU3io6cWKghE5OgInKaAgGBzzqCwOwUPRGdiNnUaamJzCH4dn60aR648Rstyla7Lw0Lvd0BC-n5yc5ZeWbyaSOMNxrbsDJubSu9kb0hOwacj7-1lmxidbxlqcCFBnqoT51lv0g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="110872554"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/110872554/Environmental_effects_of_ozone_depletion_and_its_interactions_with_climate_change_2002_assessment"><img alt="Research paper thumbnail of Environmental effects of ozone depletion and its interactions with climate change: 2002 assessment" class="work-thumbnail" src="https://attachments.academia-assets.com/108555193/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/110872554/Environmental_effects_of_ozone_depletion_and_its_interactions_with_climate_change_2002_assessment">Environmental effects of ozone depletion and its interactions with climate change: 2002 assessment</a></div><div class="wp-workCard_item"><span>Photochemical and Photobiological Sciences</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This quadrennial Assessment was prepared by the Environmental Effects Assessment Panel (EEAP) for...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This quadrennial Assessment was prepared by the Environmental Effects Assessment Panel (EEAP) for the Parties to the Montreal Protocol. The Assessment reports on key findings on environment and health since the last full Assessment of 2006, paying attention to the interactions between ozone depletion and climate change. Simultaneous publication of the Assessment in the scientific literature aims to inform the scientific community how their data, modeling and interpretations are playing a role in information dissemination to the Parties to the Montreal Protocol, other policymakers and scientists.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="636019843a29ca47b1005064011acfa3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":108555193,"asset_id":110872554,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/108555193/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="110872554"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="110872554"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 110872554; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=110872554]").text(description); $(".js-view-count[data-work-id=110872554]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 110872554; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='110872554']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "636019843a29ca47b1005064011acfa3" } } $('.js-work-strip[data-work-id=110872554]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":110872554,"title":"Environmental effects of ozone depletion and its interactions with climate change: 2002 assessment","internal_url":"https://www.academia.edu/110872554/Environmental_effects_of_ozone_depletion_and_its_interactions_with_climate_change_2002_assessment","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":108555193,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555193/thumbnails/1.jpg","file_name":"viewcontent.pdf","download_url":"https://www.academia.edu/attachments/108555193/download_file","bulk_download_file_name":"Environmental_effects_of_ozone_depletion.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555193/viewcontent-libre.pdf?1702054370=\u0026response-content-disposition=attachment%3B+filename%3DEnvironmental_effects_of_ozone_depletion.pdf\u0026Expires=1739842295\u0026Signature=NBAhBzgSV-Cbf76m96B~QN9O08-RYoAliwWm6bdAhbBgUlXYmq4v3mzHBCvrgMUL-6cvPeWRPe~-nCVIG0OCs1CbJ1FprTjysx-iOvGiovvsme9cKI1oNgl2XyUmnYeCmAnT-GVqiLPU2rjlXS-2nDZZgb~chTDxzM457l-R1K11xUNDj3a4kDxsWXB4uWZIdiy2fFDNzwPseCa4VjnuU7fQEjMeoMCLksVmmQwhU3gw1WdhBZf5ynie6lb-VPD24kRf1jsETja5A~KQUbm7YHSiYpIh~xlC91q67oOelakPjQoQvKNr5pUyaNKBsqQFB7QJVymPIS1wmiHShB10zQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":108555192,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/108555192/thumbnails/1.jpg","file_name":"viewcontent.pdf","download_url":"https://www.academia.edu/attachments/108555192/download_file","bulk_download_file_name":"Environmental_effects_of_ozone_depletion.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/108555192/viewcontent-libre.pdf?1702052963=\u0026response-content-disposition=attachment%3B+filename%3DEnvironmental_effects_of_ozone_depletion.pdf\u0026Expires=1739842295\u0026Signature=f5mxSzK7kfS6NRxvHz~pbMnZ2xf1T5cRvs2Ldo-DBhW9FzFvdgufm1TgDkxmXCfK1PRal4eDUhKNNN2FtxS1inhFtCqzUYEHnVv3K5t-Pjrba6E~-rbT4rgV6O-2wb3cVtf05c18XaKFQaOTNH48qwz6HMItIB-ecmH~zfqYNaEoOyKvJKGaFugdxlHfF3XpcLNES-B7IezFN~yCQoJwQ8oPl5zz~xpwJTRp5oEyX8bYSGtfIiCOqtJmAho1tVtbKg9Vw4RX6SQkgsE~FaM1-snxE8eRNJ9CS8tixeNK-z6OpC4K6Jl7wd75pw3pCB4T~QxiHRtYi~sac8qQ4t~v0Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79440649"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/79440649/Climate_change_and_human_skin_cancer"><img alt="Research paper thumbnail of Climate change and human skin cancer" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/79440649/Climate_change_and_human_skin_cancer">Climate change and human skin cancer</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FGruijl">Frank De Gruijl</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://ifir.academia.edu/Rub%C3%A9nDPiacentini">Rubén D Piacentini</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/FrankGruijl">Frank Gruijl</a></span></div><div class="wp-workCard_item"><span>Photochemical & Photobiological Sciences</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79440649"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79440649"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79440649; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79440649]").text(description); $(".js-view-count[data-work-id=79440649]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79440649; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79440649']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=79440649]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79440649,"title":"Climate change and human skin cancer","internal_url":"https://www.academia.edu/79440649/Climate_change_and_human_skin_cancer","owner_id":622973,"coauthors_can_edit":true,"owner":{"id":622973,"first_name":"Rubén D","middle_initials":"","last_name":"Piacentini","page_name":"RubénDPiacentini","domain_name":"ifir","created_at":"2011-07-29T02:13:02.660-07:00","display_name":"Rubén D Piacentini","url":"https://ifir.academia.edu/Rub%C3%A9nDPiacentini"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103885677"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103885677/Repeat_UVA_exposure_of_human_skin_fibroblasts_induces_both_a_transitionary_and_recovery_DNA_methylation_response"><img alt="Research paper thumbnail of Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response" class="work-thumbnail" src="https://attachments.academia-assets.com/103766942/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103885677/Repeat_UVA_exposure_of_human_skin_fibroblasts_induces_both_a_transitionary_and_recovery_DNA_methylation_response">Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response</a></div><div class="wp-workCard_item"><span>Epigenomics</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aim: UVA radiation drives skin photoaging in the dermis, plausibly via persistent changes to DNA ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aim: UVA radiation drives skin photoaging in the dermis, plausibly via persistent changes to DNA methylation in dermal fibroblasts. Methods: Genome-wide DNA methylation changes after five repeated daily UVA doses were determined at 48 h (transitionary) and 1 week (recovery) post final irradiation. Results: Differential methylation was found at the transitionary time point in active chromatin states near genes that are highly expressed in fibroblasts and are involved in cellular defensive mechanisms; the majority of these methylation differences were restored to control levels after 7 day recovery. At the recovery time point, new differential methylation occurred at repressed regions near developmental genes, normally weakly expressed in fibroblasts. Conclusion: UVA irradiation induces transitionary and recovery-associated DNA methylation responses in fibroblasts with contrasting functional characteristics.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ca35be1f17b530adcd075e7d1a54347e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103766942,"asset_id":103885677,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103766942/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103885677"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103885677"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103885677; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103885677]").text(description); $(".js-view-count[data-work-id=103885677]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103885677; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103885677']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ca35be1f17b530adcd075e7d1a54347e" } } $('.js-work-strip[data-work-id=103885677]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103885677,"title":"Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response","internal_url":"https://www.academia.edu/103885677/Repeat_UVA_exposure_of_human_skin_fibroblasts_induces_both_a_transitionary_and_recovery_DNA_methylation_response","owner_id":35121385,"coauthors_can_edit":true,"owner":{"id":35121385,"first_name":"Frank","middle_initials":null,"last_name":"Gruijl","page_name":"FrankGruijl","domain_name":"independent","created_at":"2015-09-21T05:16:12.839-07:00","display_name":"Frank Gruijl","url":"https://independent.academia.edu/FrankGruijl"},"attachments":[{"id":103766942,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/103766942/thumbnails/1.jpg","file_name":"epi-2019-025120230626-1-yg2xy9.pdf","download_url":"https://www.academia.edu/attachments/103766942/download_file","bulk_download_file_name":"Repeat_UVA_exposure_of_human_skin_fibrob.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/103766942/epi-2019-025120230626-1-yg2xy9-libre.pdf?1687779672=\u0026response-content-disposition=attachment%3B+filename%3DRepeat_UVA_exposure_of_human_skin_fibrob.pdf\u0026Expires=1739842295\u0026Signature=G1Uq7-Umqnv8wcazTBPD9jakYieBqj-GcsnOlbRAS8YBOpKs6HagvsS8iAJvNUFy2WGaoZ6PpD9VhgXpnq9mL8J5WGvzGO4S5ZmgsijU0vbhSw0nZ0X-DuZHEkVdPOqxdsHr59fkuXOlFN2XrVyNfsTyoFkC1bD8YmYxhSKFlU-1M3y35w~fK5LjaFkAqKmKUazYuoDkOeztjCm2bNcAbmmQoe-hP-vAGS~0CONJBmPcJAOd-V968DlIGhp9jugH9JIUklwApRdLbtHJc1OtDwYhNWhpSIDUmM73N0G~uA5fgfY3dwe17eK~tvkexaB-pLWrZ3iyLnaRX8wqydZr3Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; } .sign-in-with-apple-button > div { margin: 0 auto; / This centers the Apple-rendered button horizontally }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "0e14b1c1550f40f40b9453af72d8f74635b52032d7dc8d0fb870115defbbdf10", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="3KOmU_h85M87SwF6U2GD50LoNVKlpJGqfKkaF1l9S9HPV9E7DakLiVvuZ2csPgVA9FSS5LMOxuENk8vfyBd0Jw" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://independent.academia.edu/FrankGruijl" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="eDIChjcl26wIoPWC0NIN4lrL-O0k8EhBOUH7XD5ryw1rxnXuwvA06mgFk5-vjYtF7HdfWzJaHwpIeyqUrwH0-w" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2025</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>