Design von Biomaterialien mit Biotechnologie – Institut f眉r Technische Chemie

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<div class="column"> <h1 class="c-headline c-headline--h1 u-text--hyphens"> Arbeitsgruppe Design von Biomaterialien mit Biotechnologie </h1> <div class="c-text-media "> <div class="c-text-media__text"> <h2 class="c-headline--h2">AG-Leitung Dr. Iliyana Pepelanova</h2> </div> </div> </div> </div> </div> </div> <main class="c-section__wrapper"> <div id="c71001" class="c-section"> <div class="row"> <div class="column"> <div class="row c-section-grid--50-50"> <div class="small-12 medium-6 c-section-grid__column column "> <div id="c70999" class="c-section__element"> <div class="c-headline__equalizer" data-mh="ce-headline-71001"> </div> <div class="c-text-media "> <figure class="c-figure "> <div data-responsive-image="1" class="c-figure__image"> <img data-src="https://www.tci.uni-hannover.de/fileadmin/_processed_/d/d/csm_AG-Pepelanova_Biomedizintechnik_b40a536c64.jpg" /> <img min-width="570" data-src="https://www.tci.uni-hannover.de/fileadmin/_processed_/d/d/csm_AG-Pepelanova_Biomedizintechnik_479138e62a.jpg" /> <img min-width="700" data-src="https://www.tci.uni-hannover.de/fileadmin/_processed_/d/d/csm_AG-Pepelanova_Biomedizintechnik_5dea72693c.jpg" /> </div> </figure> <figure class="c-figure "> <div data-responsive-image="1" class="c-figure__image"> <img data-src="https://www.tci.uni-hannover.de/fileadmin/_processed_/0/8/csm_AG-Pepelanova_Toolkit_9612936463.jpg" /> <img min-width="570" data-src="https://www.tci.uni-hannover.de/fileadmin/_processed_/0/8/csm_AG-Pepelanova_Toolkit_4c6582a3a2.jpg" /> <img min-width="700" data-src="https://www.tci.uni-hannover.de/fileadmin/_processed_/0/8/csm_AG-Pepelanova_Toolkit_d3523dd858.jpg" /> </div> </figure> </div> </div> </div> <div class="small-12 medium-6 c-section-grid__column column "> <div id="c71000" class="c-section__element"> <div class="c-headline__equalizer" data-mh="ce-headline-71001"> </div> <div class="c-text-media "> <div class="c-text-media__text"> <p>Wir arbeiten an der Entwicklung von biotechnologischen Prozessen zur Bereitstellung von Materialien f眉r die regenerative Medizin. Die Herstellung von rekombinanten Proteinen aus der extrazellul盲ren Matrix f眉r Anwendungen im Bereich des Tissue Engineering und der 3D Zellkultivierung ist unser Schwerpunkt. Dabei werden biologisch aktive Teilsequenzen aus humanen Strukturproteinen wie Kollagen oder Fibrinogen in GRAS Organismen wie <em>E. coli</em> oder <em>P. pastoris</em> produziert. Durch die Produktion in einfachen Mikroorganismen kann eine virusfreie, skalierbare und kosteneffektive Herstellung der humanen Strukturproteine erfolgen. Gew眉nschte mechanische oder stimulus-responsive Eigenschaften der Strukturproteine werden durch chemische Modifizierung erzielt. Ein zus盲tzlicher Fokus der Arbeiten der Gruppe liegt auf der Produktion und Charakterisierung von rekombinanten Enzymen und Wachstumsfaktoren, die eine Rolle bei Regenerations- und Heilungsprozessen spielen.</p> <p>Ein weiteres Forschungsthema der Gruppe bildet die Synthese von semi-synthetischen Proteinhydrogelen (GelMA und rekombinante Strukturproteine) und deren Anwendung als Bioinks und 3D Zellkulturmatrices. Unsere Arbeiten sind in der Forschungslinie SMART BIOTECS angesiedelt und werden in enger Kooperation mit klinischen Forschergruppen durchgef眉hrt.  </p> </div> </div> </div> </div> </div> </div> </div> </div> <div id="c74763" class="c-section"> <div class="row"> <div class="column"> <div class="row align-center c-section__grid-indent" > <div class="small-12 medium-8 column c-section-grid__column"> <div id="c74762" class="c-section__element"> <div class="c-headline__equalizer" data-mh="ce-headline-74763"> </div> <div class="c-text-media "> <div class="c-text-media__text"> <h3 class="c-headline--h3">Kernkompetenzen der AG Pepelanova</h3><ul> <li>Biotechnologische Herstellung von humanen Strukturproteinen (Fibrinogen, Kollagensequenzen) in einfachen Mikroorganismen</li> <li>Biotechnologische Herstellung von bioaktiven Nanopills (Lipoxygenasen)</li> <li>Semi-synthetische Hydrogele f眉r Bioprinting und 3D Zellkultivierung (GelMA Hydrogele)</li> </ul> </div> </div> </div> </div> </div> </div> </div> </div> <div id="c74276" class="c-section"> <div class="c-section c-section--bg-color"> <div class="row"> <div class="column"> <div id="c70997" class="c-section__element"> <div class="c-headline__equalizer" data-mh="ce-headline-74276"> </div> <div class="row c-section-grid--33-33-33"> <div class="column small-12 medium-4 large-4 c-section-grid__column "> <div id="c70995" class="c-section__element"> <div class="c-card c-card--icon"> <div class="c-card__image-wrap c-card__spacer-h"> <div class="c-card__icon u-icon u-icon--user15"></div> <img class="c-card__image" src="/typo3conf/ext/luh_website/Resources/Public/Images/icon_background.gif" width="16" height="9" alt="" /> </div> <div class="c-card__text-content" data-mh="ce-image-card-70997"> <div class="c-card__title"> Dr. Iliyana Pepelanova </div> </div> </div> </div> </div> <div class="column small-12 medium-4 large-4 c-section-grid__column "> <div id="c70993" class="c-section__element"> <div class="c-card c-card--icon"> <div 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