Small Business | Grants & Funding

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Learn about assistance programs, how to identify a potential funding organization, and past NIH funding." class="nav-link position-relative px-0 btn btn-primary rounded-0 text-lg-center text-uppercase fw-bold me-0 py-2 px-3 py-lg-3 d-flex collapsed justify-content-between d-lg-block bg-gradient shadow" data-bs-toggle="collapse" data-bs-target="#Funding" aria-expanded="false" data-drupal-link-system-path="node/23"> Funding <i class="bi bi-caret-down-fill"></i> </a> <div> <div class="container-fluid rounded-0 w-100 start-0 bg-white text-black shadow position-absolute collapse z-3" id="Funding" data-bs-parent="#block-nihod5-subtheme-main-navigation"> <div class="container"> <div class="row"> <div class="col-12 col-lg-6 px-4 p-lg-5"> <strong class="h4 d-none d-lg-block text-secondary">Funding</strong> <p class="d-none d-lg-block">As the largest public funder of biomedical research in the world, NIH supports a variety of programs from grants and contracts to loan repayment. Learn about assistance programs, how to identify a potential funding organization, and past NIH funding.</p> <a href="/funding" title="As the largest public funder of biomedical research in the world, NIH supports a variety of programs from grants and contracts to loan repayment. Learn about assistance programs, how to identify a potential funding organization, and past NIH funding." class="btn btn-block btn-primary ms-0 my-3 my-lg-0 px-4" data-drupal-link-system-path="node/23">Explore Funding</a> </div> <div class="col-12 col-lg-6 px-4 pb-3 p-lg-5 ps-lg-0"> <div class="border-start ps-4"> <ul class="bg-white p-0 start-0 ps-lg-5 border-lg-start border-light h-100 menu-level-1"> <li class="nav-item d-flex flex-wrap flex-column position-static mb-2"> <a href="/funding/nih-guide-for-grants-and-contracts" class="1 nav-link position-relative px-0 py-2 py-lg-1 fw-bold" data-drupal-link-system-path="node/45">NIH Guide for Grants and Contracts</a> </li> <li class="nav-item d-flex flex-wrap flex-column position-static mb-2"> <a href="/funding/funding-categories" class="1 nav-link position-relative px-0 py-2 py-lg-1 fw-bold" data-drupal-link-system-path="node/21">Funding Categories</a> </li> <li class="nav-item d-flex flex-wrap flex-column position-static mb-2"> <a href="/funding/find-a-fit-for-your-research-nih-institutes-centers-offices" class="1 nav-link position-relative px-0 py-2 py-lg-1 fw-bold" data-drupal-link-system-path="node/25">Find a Fit for Your Research: NIH Institutes, Centers, and Offices</a> </li> <li class="nav-item d-flex flex-wrap flex-column position-static mb-2"> <a href="/funding/explore-data-on-funded-projects" class="1 nav-link position-relative px-0 py-2 py-lg-1 fw-bold" data-drupal-link-system-path="node/24">Explore Who and What NIH Funds</a> </li> </ul> </div> </div> </div> </div> </div> </div> </li> <li class="nav-item d-flex flex-wrap flex-column position-static d-lg-block flex-grow-1"> <a href="/grants-process" title="Take time to learn about each step in the grants process from planning to apply through developing and submitting your application to award and post-award reporting." class="nav-link position-relative px-0 btn btn-primary rounded-0 text-lg-center text-uppercase fw-bold me-0 py-2 px-3 py-lg-3 d-flex collapsed justify-content-between d-lg-block" data-bs-toggle="collapse" data-bs-target="#GrantsProcess" aria-expanded="false" data-drupal-link-system-path="node/49"> Grants Process <i class="bi bi-caret-down-fill"></i> </a> <div> <div class="container-fluid rounded-0 w-100 start-0 bg-white text-black shadow position-absolute collapse z-3" id="GrantsProcess" data-bs-parent="#block-nihod5-subtheme-main-navigation"> <div class="container"> <div class="row"> <div class="col-12 col-lg-6 px-4 p-lg-5"> <strong class="h4 d-none d-lg-block text-secondary">Grants Process</strong> <p class="d-none d-lg-block">Take time to learn about each step in the grants process from planning to apply through developing and submitting your application to award and post-award reporting.</p> <a href="/grants-process" title="Take time to learn about each step in the grants process from planning to apply through developing and submitting your application to award and post-award reporting." class="btn btn-block btn-primary ms-0 my-3 my-lg-0 px-4" data-drupal-link-system-path="node/49">Explore Grants Process</a> </div> <div class="col-12 col-lg-6 px-4 pb-3 p-lg-5 ps-lg-0"> <div class="border-start ps-4"> <ul class="bg-white p-0 start-0 ps-lg-5 border-lg-start border-light h-100 menu-level-1"> <li class="nav-item d-flex flex-wrap flex-column position-static mb-2"> <a href="/grants-process/plan-to-apply" title="Plan ahead, assess funding opportunities, and take other early steps. Learn to work with your organization, assess resources and teammates, identify a funding opportunity, check application policies, and lay out your timeline." class="1 nav-link position-relative px-0 py-2 py-lg-1 fw-bold" data-drupal-link-system-path="node/1073">Plan to Apply</a> </li> <li class="nav-item d-flex flex-wrap flex-column position-static mb-2"> <a href="/grants-process/write-application" title="Find the official grant application instructions, preview application forms, get advice on grant writing, check out sample grant applications, and read our tips on specific application attachments and sections." class="1 nav-link position-relative px-0 py-2 py-lg-1 fw-bold" data-drupal-link-system-path="node/670">Write Application</a> </li> <li class="nav-item d-flex flex-wrap flex-column position-static mb-2"> <a href="/grants-process/submit" title="Learn about the steps you must take after filling out your application forms to complete the submission process, how NIH checks your application for completeness prior to review, and NIH submission policies." class="1 nav-link position-relative px-0 py-2 py-lg-1 fw-bold" data-drupal-link-system-path="node/43">Submit</a> </li> <li class="nav-item d-flex flex-wrap flex-column position-static mb-2"> <a href="/grants-process/review" title="What happens between the time you submit the application and NIH lets you know you will be funded? Learn more about receipt and referral and NIH’s peer review process." class="1 nav-link position-relative px-0 py-2 py-lg-1 fw-bold" data-drupal-link-system-path="node/1082">Review</a> </li> <li class="nav-item d-flex flex-wrap flex-column position-static mb-2"> <a href="/grants-process/award" title="When NIH awards a grant, we are formalizing our partnership with the recipient to ensure compliance with federal laws, regulations and policies." class="1 nav-link position-relative px-0 py-2 py-lg-1 fw-bold" data-drupal-link-system-path="node/1083">Award</a> </li> <li class="nav-item d-flex flex-wrap flex-column position-static mb-2"> <a href="/grants-process/post-award-monitoring-and-reporting" title="If your organization is the recipient of a grant from the NIH, you will need to pay close attention to the terms of award to be successful stewards of federal funds. Learn about reporting and monitoring requirements." class="1 nav-link position-relative px-0 py-2 py-lg-1 fw-bold" data-drupal-link-system-path="node/349">Post-Award Monitoring and Reporting</a> </li> </ul> </div> </div> </div> </div> </div> </div> </li> <li class="nav-item d-flex flex-wrap flex-column position-static d-lg-block flex-grow-1"> <a href="/policy-and-compliance" title="By accepting a grant award, recipients agree to comply with the requirements in the NIH Grants Policy Statement unless the notice of award states otherwise." class="nav-link position-relative px-0 btn btn-primary rounded-0 text-lg-center text-uppercase fw-bold me-0 py-2 px-3 py-lg-3 d-flex collapsed justify-content-between d-lg-block" data-bs-toggle="collapse" data-bs-target="#PolicyCompliance" aria-expanded="false" data-drupal-link-system-path="node/3"> Policy & Compliance <i class="bi bi-caret-down-fill"></i> </a> <div> <div class="container-fluid rounded-0 w-100 start-0 bg-white text-black shadow position-absolute collapse z-3" id="PolicyCompliance" data-bs-parent="#block-nihod5-subtheme-main-navigation"> <div class="container"> <div class="row"> <div class="col-12 col-lg-6 px-4 p-lg-5"> <strong class="h4 d-none d-lg-block text-secondary">Policy & Compliance</strong> <p class="d-none d-lg-block">By accepting a grant award, recipients agree to comply with the requirements in the NIH Grants Policy Statement unless the notice of award states otherwise.</p> <a href="/policy-and-compliance" title="By accepting a grant award, recipients agree to comply with the requirements in the NIH Grants Policy Statement unless the notice of award states otherwise." class="btn btn-block btn-primary ms-0 my-3 my-lg-0 px-4" data-drupal-link-system-path="node/3">Explore Policy & Compliance</a> </div> <div class="col-12 col-lg-6 px-4 pb-3 p-lg-5 ps-lg-0"> <div class="border-start ps-4"> <ul class="bg-white p-0 start-0 ps-lg-5 border-lg-start border-light h-100 menu-level-1"> <li class="nav-item 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</div> </li> <li class="level-2 py-0 px-0 border-0 list-inline"> <a href="/funding/funding-categories/challenges-and-prizes" class="dropdown-item py-2 ps-2 text-wrap" role="button" title="Expand menu Challenges and Prizes" data-drupal-link-system-path="node/32">Challenges and Prizes</a> <div class="d-none"> </div> </li> </ul> </div> </li> <li class="level-1 py-0 px-0 border-0 list-inline"> <a href="/funding/find-a-fit-for-your-research-nih-institutes-centers-offices" class="dropdown-item py-2 ps-2 text-wrap fw-bold" role="button" title="Expand menu Find a Fit for Your Research: NIH Institutes, Centers, and Offices" data-drupal-link-system-path="node/25">Find a Fit for Your Research: NIH Institutes, Centers, and Offices</a> <div class="d-none"> </div> </li> <li class="level-1 py-0 px-0 border-0 list-inline"> <a href="/funding/explore-data-on-funded-projects" class="dropdown-item py-2 ps-2 text-wrap fw-bold" role="button" title="Expand menu Explore Who and What NIH Funds" data-drupal-link-system-path="node/24">Explore Who and What NIH Funds</a> <div class="d-none"> </div> </li> </ul> </div> </li> </ul> </nav> </div> </div> <div class="order-1 order-lg-2 syndicate col-12 col-lg-9 ps-0 ps-lg-5"> <div class="region region-content"> <div data-drupal-messages-fallback class="hidden"></div> <div id="block-nihod5-subtheme-page-title" class="block block-core block-page-title-block"> <h1><strong><span class="field field--name-title field--type-string field--label-hidden">Small Business</span> </strong></h1> </div> <div id="block-nihod5-subtheme-content" class="block block-system block-system-main-block"> <article class="node node--type-page node--view-mode-full"> <div class="node__content"> <div class="layout layout--twocol-section layout--twocol-section--67-33"> <div class="layout__region layout__region--first"> <div class="block block-layout-builder block-field-block-node-page-field-scope-note"> <div class="clearfix text-formatted field field--name-field-scope-note field--type-text-long field--label-hidden field__item"><p>Small businesses are eligible to apply to many of NIH’s standard programs. In addition, NIH has funding programs specifically aimed at small businesses.</p></div> </div> <div class="block block-layout-builder block-field-block-node-page-body"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>NIH is required by statute to reserve a portion of its annual extramural budget for projects under the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. These programs, also known as America’s Seed Fund, offer small business entrepreneurs a chance to obtain non-dilutive funding for early-stage research and development.</p><p>The goals of our small business program are to:</p><ul><li>Stimulate technological innovation</li><li>Meet federal research and development needs</li><li>Increase private sector commercialization of innovations developed through federal R&D funding</li><li>Foster and encourage participation in innovation and entrepreneurship by <a href="https://diversity.nih.gov/about-us/population-underrepresented">socially and economically disadvantaged (SDB) persons and women-owned small businesses (WOSB)</a>.</li></ul><p>Although the goals are the same and the money always goes to the small business, a key difference between the SBIR and STTR programs is whether partnerships with a non-profit research institution are allowed (SBIR) or required (STTR).  </p></div> </div> </div> <div class="layout__region layout__region--second"> <div class="block block-layout-builder block-field-block-node-page-field-body-3"> <div class="clearfix text-formatted field field--name-field-body-3 field--type-text-long field--label-hidden field__item"><div data-ds-id="1ysql345" class="card mb-3 text-center ms-0 ms-lg-5 rounded"> <div class="bg-primary h1 mx-auto p-3 rounded-circle text-white mt-4"> <i class="bi bi-search d-flex"></i> </div> <div class="card-body"> <h5 class="card-title">Search for Small Business Funding Opportunities</h5> <p class="card-text my-3">The NIH Guide for Grants and Contracts is NIH's official publication of notices of grant policies, guidelines, and funding opportunities.</p> <a class="btn btn-primary mx-auto mb-0" href="/funding/nih-guide-for-grants-and-contracts?query=&type=active,activenosis&foa=all&parent_orgs=all&orgs=all&ac=R41,R42,R43,R44,SB1,U43,U44,UB1,UT1,UT2&ct=all&pfoa=all&date=01021991-09172024&fields=all&spons=true&noticeSubject=all" target="_blank">View Current Funding Opportunities</a> </div> </div></div> </div> <div class="block block-block-content block-block-content-990b0cd8-84f7-42bc-a7d0-62d82f8bd758"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"> <div data-ds-id="1ysql345" class="bg-secondary-subtle border-secondary card mb-3 text-center pt-4 ms-0 ms-lg-5 rounded"> <div class="bg-secondary h1 mx-auto p-3 rounded-circle text-white"> <i class="bi bi-card-checklist d-flex"></i> </div> <div class="card-body"> <h5 class="card-title">Grants Process</h5> <p class="card-text my-3">Ready to develop your application? Learn from a step-by-step guide.</p> <a class="btn btn-secondary mx-auto mb-0 p-2 px-5" href="/grants-process">Learn Process</a> </div> </div></div> </div> </div> </div> <div class="layout layout--onecol"> <div class="layout__region layout__region--content"> <div class="block block-layout-builder block-field-block-node-page-field-body-2"> <div class="clearfix text-formatted field field--name-field-body-2 field--type-text-long field--label-hidden field__item"><div class="card my-4" data-ds-id="pb43iac5"><div class="card-body"><p class="card-text">Visit our dedicated <a href="https://seed.nih.gov/">Small business Education and Entrepreneurial Development (SEED)</a> website for an in-depth explanation of:</p><ul><li>Available small business funding</li><li>Technical and business assistance</li><li>Commercialization programs</li><li>Supplement programs to promote diversity in small business research and development</li></ul></div></div><h2>Review Criteria</h2><p>To find the criteria reviewers will use to evaluate your application, see Section V of your funding opportunity.</p><p>Still looking for a funding opportunity? Check out the <a href="/funding/nih-guide-for-grants-and-contracts/parent-announcements#res">Small Business Parent Announcements</a>, which are broad funding opportunities allowing applicants to submit investigator-initiated applications. Parent Announcements include the minimum standard review criteria appropriate for their program.</p></div> </div> <div class="block block-layout-builder block-field-block-node-page-field-body-4"> <div class="clearfix text-formatted field field--name-field-body-4 field--type-text-long field--label-hidden field__item"><h2>Programs</h2> <p>The SBIR and STTR programs are divided into several phases that support applicants at different stages of development. Phase I awards support projects to establish technical merit and feasibility while Phase II awards support projects to continue R&D efforts initiated in Phase I. Some opportunities also accept Phase IIB applications requesting additional funding for Phase II projects that require extraordinary time and effort in the R&D phase.</p> <p>Small businesses awarded Phase II and Phase IIB funding may be interested in our Commercialization Readiness Program which offers assistance to pursue commercialization.</p> <div data-ds-id="k4p5mvp5" class="accordion accordion-flush" id="career-stage"> <div class="accordion-item border border-light border-2 mb-2"> <h2 class="accordion-header" id="headingOne1"> <button class="accordion-button bg-tertiary bg-opacity-50" type="button" data-bs-toggle="collapse" data-bs-target="#collapseOne1" aria-expanded="true" aria-controls="collapseOne1"><strong class="text-dark"> Small Business Innovation Research Grants (SBIR)</strong></button> </h2> <div class="accordion-collapse collapse show" id="collapseOne1" aria-labelledby="headingOne1" data-bs-parent="#career-stage"> <div class="accordion-body"> <ul> <li><a href="/funding/activity-codes/R43">Small Business Innovation Research Grants (SBIR) - Phase I (R43)</a></li> <li><a href="/funding/activity-codes/R44">Small Business Innovation Research Grants (SBIR) - Phase II (R44)</a></li> <li><a href="/funding/activity-codes/U43">Small Business Innovation Research (SBIR) Cooperative Agreements - Phase I (U43)</a></li> <li><a href="/funding/activity-codes/U44">Small Business Innovation Research (SBIR) Cooperative Agreements - Phase II (U44)</a></li> </ul> </div> </div> </div> <div class="accordion-item border border-light border-2 mb-2"> <h2 class="accordion-header" id="headingTwo"> <button class="accordion-button bg-tertiary bg-opacity-50 collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseTwo1" aria-expanded="false" aria-controls="collapseTwo1"><strong class="text-dark"> Small Business Technology Transfer (STTR)</strong></button> </h2> <div class="accordion-collapse collapse" id="collapseTwo1" aria-labelledby="headingTwo" data-bs-parent="#career-stage"> <div class="accordion-body"> <ul> <li><a href="/funding/activity-codes/R41">Small Business Technology Transfer (STTR) Grants - Phase I (R41)</a></li> <li><a href="/funding/activity-codes/R42">Small Business Technology Transfer (STTR) Grants - Phase II (R42)</a></li> <li><a href="/funding/activity-codes/UT1">Small Business Technology Transfer (STTR) - Cooperative Agreements - Phase I (UT1)</a></li> <li><a href="/funding/activity-codes/UT2">Small Business Technology Transfer (STTR) - Cooperative Agreements - Phase II (UT2)</a></li> </ul> </div> </div> </div> <div class="accordion-item border border-light border-2 mb-2"> <h2 class="accordion-header" id="headingThree"> <button class="accordion-button bg-tertiary bg-opacity-50 collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapseThree1" aria-expanded="false" aria-controls="collapseThree1"><strong class="text-dark"> Commercialization Readiness Program</strong></button> </h2> <div class="accordion-collapse collapse" id="collapseThree1" aria-labelledby="headingThree" data-bs-parent="#career-stage"> <div class="accordion-body"> <ul> <li><a href="/funding/activity-codes/SB1">Commercialization Readiness Program (SB1)</a></li> <li><a href="/funding/activity-codes/UB1">Commercialization Readiness Program - Cooperative Agreement (UB1)</a></li> </ul> </div> </div> </div> </div></div> </div> <div class="block block-layout-builder block-extra-field-block-node-page-workbench-moderation-control"> </div> </div> </div> </div> </article> </div> <div id="block-grants-learningcenterresources" class="block block-oer-resources-module block-learning-center-resources-block"> <div class="border-2 border-secondary border-top container mb-5" id="general-resource-wrapper"> <div class="row"> <h3 class="border-5 border-secondary border-top col-12 col-md-3 pt-3 text-secondary">Resources</h3> <div class="border-5 border-top border-white col-12 col-md-9 pt-3"> <div class="upcoming-events-block mb-4"> <h4> <strong>Upcoming Events</strong> </h4> <ul id="upcoming-events"></ul> </div> <div class="general-resources-block mb-4"> <h4> <strong>General</strong> </h4> <p> <ul><li><a href="https://seed.nih.gov/">NIH SEED website</a></li><li><a href="/grants/policy/nihgps/HTML5/section_18/18.5_small_business_innovation_research_and_small_business_technology_transfer_programs.htm">NIH Grants Policy Statement Section 18.5 Small Business Innovation Research and Small Business Technology Transfer Programs</a></li><li><a href="/funding/activity-codes">Full list of Activity Codes</a></li><li>PHS Act <a href="/grants/authorization.htm">Authorization</a> to collection information</li></ul> </p> </div> <div class="videos-block mb-4"> <h4> <strong>Videos</strong> </h4> <ul id="videos" class="videos-see-more"></ul> </div> </div> </div> </div> <script> function collapseMore(collapseList, addDiv, btnName) { if (collapseList) { const items = collapseList.querySelectorAll("li"); 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