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PAD widely prevalent, consequences could be dire | Cardiology Today

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2UsIGlzIHBsYXRlbGV0IHJlYWN0aXZpdHkgYW5kIGdlbm90eXBlIHRlc3RpbmcgYW4gYWlkIHRvIGNsaW5pY2FsIGRlY2lzaW9uIG1ha2luZyBvciBhbiBpbnZlc3RpZ2F0aW9uYWwgdG9vbD88L2E+PC9ub3NjcmlwdD4NCg0KPHAgY2xhc3M9InBvbGwtcmVsYXRlZC1saW5rIj48YSBocmVmPSIvY2FyZGlvbG9neS9wb2xsLWFyY2hpdmUiPlZpZXcgcGFzdCBwb2xscyAmcmFxdW87PC9hPjwvcD5kAgcPZBYEAgEPZBYCAgEPZBYCZg8WAh8ABcoBPCEtLSBDYXJkaW9sb2d5X1RleHRMaW5rMSAtLT4KPGRpdiBpZD0nZGl2LWdwdC1hZC0xMzY5MTY5MTM0MzA2LTYnPgo8c2NyaXB0IHR5cGU9J3RleHQvamF2YXNjcmlwdCc+Cmdvb2dsZXRhZy5jbWQucHVzaChmdW5jdGlvbigpIHsKZ29vZ2xldGFnLmRpc3BsYXkoJ2Rpdi1ncHQtYWQtMTM2OTE2OTEzNDMwNi02Jyk7Cn0pOwo8L3NjcmlwdD4KPC9kaXY+CmQCAg9kFgICAQ9kFgJmDxYCHwAFygE8IS0tIENhcmRpb2xvZ3lfVGV4dExpbmsyIC0tPgo8ZGl2IGlkPSdkaXYtZ3B0LWFkLTEzNjkxNjkxMzQzMDYtNyc+CjxzY3JpcHQgdHlwZT0ndGV4dC9qYXZhc2NyaXB0Jz4KZ29vZ2xldGFnLmNtZC5wdXNoKGZ1bmN0aW9uKCkgewpnb29nbGV0YWcuZGlzcGxheSgnZGl2LWdwdC1hZC0xMzY5MTY5MTM0MzA2LTcnKTsKfSk7Cjwvc2NyaXB0Pgo8L2Rpdj4KZAIJD2QWAmYPFgIfAAXlATwhLS0gQ2FyZGlvbG9neV9WYXNjdWxhck1lZGljaW5lX01hcmtldGluZ1JlY3RhbmdsZTEgLS0+CjxkaXYgaWQ9J2Rpdi1ncHQtYWQtMTM2OTE2OTEzNDMwNi0xJz4KPHNjcmlwdCB0eXBlPSd0ZXh0L2phdmFzY3JpcHQnPgpnb29nbGV0YWcuY21kLnB1c2goZnVuY3Rpb24oKSB7Cmdvb2dsZXRhZy5kaXNwbGF5KCdkaXYtZ3B0LWFkLTEzNjkxNjkxMzQzMDYtMScpOwp9KTsKPC9zY3JpcHQ+CjwvZGl2PgpkAgsPZBYCZg8WAh8ABeUBPCEtLSBDYXJkaW9sb2d5X1Zhc2N1bGFyTWVkaWNpbmVfTWFya2V0aW5nUmVjdGFuZ2xlMiAtLT4KPGRpdiBpZD0nZGl2LWdwdC1hZC0xMzY5MTY5MTM0MzA2LTInPgo8c2NyaXB0IHR5cGU9J3RleHQvamF2YXNjcmlwdCc+Cmdvb2dsZXRhZy5jbWQucHVzaChmdW5jdGlvbigpIHsKZ29vZ2xldGFnLmRpc3BsYXkoJ2Rpdi1ncHQtYWQtMTM2OTE2OTEzNDMwNi0yJyk7Cn0pOwo8L3NjcmlwdD4KPC9kaXY+CmQCEQ9kFgICAQ9kFgJmDxYCHwAF4wE8IS0tIENhcmRpb2xvZ3lfVmFzY3VsYXJNZWRpY2luZV9Cb3R0b21MZWFkZXJib2FyZCAtLT4KPGRpdiBpZD0nZGl2LWdwdC1hZC0xMzY5MTY5MTM0MzA2LTAnPgo8c2NyaXB0IHR5cGU9J3RleHQvamF2YXNjcmlwdCc+Cmdvb2dsZXRhZy5jbWQucHVzaChmdW5jdGlvbigpIHsKZ29vZ2xldGFnLmRpc3BsYXkoJ2Rpdi1ncHQtYWQtMTM2OTE2OTEzNDMwNi0wJyk7Cn0pOwo8L3NjcmlwdD4KPC9kaXY+CmQCDw8PFgIfAWdkZBgDBRtIb3Jpem9udGFsTWVudSRNdWx0aVZpZXdOYXYPD2QCAWQFMGxheW91dF8wJGN0bDAxJHNpZGViYXJiZWxvd2FkXzAkTXVsdGlWaWV3Q29udGVudA8PZAIBZAUITVZIZWFkZXIPD2RmZA2m2EoLGLXdjUodocMpT4IzeakYGEariUzZVNveHH+B"/> 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id="breadcrumbs"> <a href="/web/20131105185104/http://www.healio.com/"> Healio</a> <span>&#8250;</span> <a href="/web/20131105185104/http://www.healio.com/cardiology"> Cardiology</a> <span>&#8250;</span> <a href="/web/20131105185104/http://www.healio.com/cardiology/vascular-medicine"> Vascular Medicine</a> <span>&#8250;</span> <a href="/web/20131105185104/http://www.healio.com/cardiology/vascular-medicine/news"> News</a> </p> <!-- /breadcrumbs --> <!-- related links --> <!--googleoff: index--><div id="SeeAlso" class="related-links"><h3>See Also</h3><ul><li><a href="https://web.archive.org/web/20131105185104/http://www.healio.com/cardiology/vascular-medicine/news/online/%7Ba440c7d2-9b59-4aa4-8f25-37d567b4737f%7D/ht-linked-to-reduced-risk-for-pad-in-postmenopausal-women">HT linked to reduced risk for PAD in postmenopausal women ...</a></li><li><a href="https://web.archive.org/web/20131105185104/http://www.healio.com/cardiology/vascular-medicine/news/online/%7B32aaea9a-65c6-4d4a-972a-d70dc1664493%7D/pure-hypertension-prevalent-but-uncontrolled-worldwide">PURE: Hypertension prevalent but uncontrolled worldwide ...</a></li><li><a href="https://web.archive.org/web/20131105185104/http://www.healio.com/cardiology/vascular-medicine/news/online/%7B0f610450-218b-44e6-a80e-ad4bb630485a%7D/sharp-increase-in-global-prevalence-of-pad">Sharp increase in global prevalence of PAD</a></li></ul></div><!-- /related links --><!--googleon: index> <!-- /related links --> <input name="layout_0$maincontent_0$seeAlsoInsertUnderParagraph" type="hidden" id="layout_0_maincontent_0_seeAlsoInsertUnderParagraph" value="1"/> <!-- content --> <div class="content"> <h2> PAD widely prevalent, consequences could be dire</h2> <h3 class="deck"> </h3> <p class="main-subtitle"> </p> <div class="social-links-top"> <ul class="share"> <li class="l1"><a href="javascript:void(0)" class="facebook-link" target="_new">Facebook</a></li> <li class="l2"><a href="javascript:void(0)" class="twitter-link" target="_new">Tweet</a></li> <li class="l3"><a href="javascript:void(0)" class="linkedin-link">Share</a></li> </ul> </div> <ul class="meta-info"> <li> Cardiology Today, October 2013</li> </ul> <div class="wyContent"> <p>New reports have suggested that the prevalence of peripheral artery disease is increasing sharply. According to a recent meta-analysis, an estimated 202 million people worldwide had peripheral artery disease in 2010, up 23.5% from 164 million in 2000.</p> <div class="mug right"><img alt="" width="90" height="120" src="/web/20131105185104im_/http://www.healio.com/~/media/News/Print/Cardiology Today/2013/10_October/10_3928_1081_597x_20130101_00_1313999/Fowkes_Gerry.jpg"/>&nbsp; <p class="name"><strong>F. Gerald R. Fowkes</strong></p> </div> <p><!-- /mug right --></p> <p>&ldquo;There is a general lack of awareness of this condition among health professionals, yet it is an indicator of high risk for major cardiovascular events and death, requiring preventive measures,&rdquo; said <strong>F. Gerald R. Fowkes, PhD, FRCPE, FFPH,</strong> one of the researchers of the meta-analysis that was published online by <i>The Lancet</i> in August.</p> <div class="figure"><a href="/web/20131105185104/http://www.healio.com/~/media/News/Print/Cardiology Today/2013/10_October/10_3928_1081_597x_20130101_00_1313999/Jaff_Michael.jpg"><img name="/~/media/News/Print/Cardiology Today/2013/10_October/10_3928_1081_597x_20130101_00_1313999/Jaff_Michael.jpg" style="border: #000000 1px solid;" alt="Michael R. Jaff, DO, Cardiology Today Editorial Board member, discusses new treatment options for PAD." src="/web/20131105185104im_/http://www.healio.com/cardiology/vascular-medicine/news/print/cardiology-today/%7B03effe2f-98c6-4f1c-b394-bbf3c0dcce85%7D/~/media/News/Print/Cardiology Today/2013/10_October/10_3928_1081_597x_20130101_00_1313999/Jaff_Michael.jpg"/></a> <p class="figcaption">Michael R. Jaff, DO, <em>Cardiology Today</em> Editorial<br/> Board member, discusses new treatment<br/> options for PAD.</p> <p class="photo-credit">Photo courtesy of: MGH Institute for Heart, Vascular<br/> and Stroke Care; reprinted with permission</p> </div> <p>In the United States and other developed countries, research and development is being invested for ways to better diagnose and treat PAD. Patients who 20 years ago would have had limbs amputated because of PAD are now having their limbs saved because physicians are better able to recognize symptoms of PAD and have more numerous and advanced treatments at their disposal. Additional treatments, including drug-coated balloons and stem cell therapy, are on the way.</p> <p>&ldquo;PAD is out there much more so in the public eye than it had been before,&rdquo; <strong>Peter Schneider, MD,</strong> chief of vascular therapy at Kaiser Foundation Hospital, Honolulu, told <i>Cardiology Today</i>. &ldquo;We have many more people interested in it, more people studying it and more dollars to pay for studies to look at it.&rdquo; </p> <p>The question for many is whether advancements in PAD awareness, diagnosis and treatment can keep up with the increasing prevalence.</p> <h4><section/>Widespread prevalence</h4> <p>Several factors may help explain why there has been a sharp growth in PAD rates since 2000. </p> <p>&ldquo;There are four major reasons,&rdquo; 
<strong>Michael R. Jaff, DO, </strong>chair of the Institute for Heart, Vascular and Stroke Care and medical director of the Vascular Center at Massachusetts General Hospital, said in an interview. &ldquo;First, the population is getting older. Most PAD is atherosclerotic in nature, and that occurs in an older population. Second, diabetes is out of control. If you look around the world for places where PAD prevalence is rising, those are also places where diabetes is highly prevalent. Third, in many places around the world, tobacco use continues to be a major risk factor for PAD, and it continues to be highly prevalent. Fourth, people are looking for PAD more. There are more therapies available now that weren&rsquo;t before. The ability to make this diagnosis is easier than it was in the past.&rdquo;</p> <p>However, Fowkes said &ldquo;none of the increase in PAD in our study can be attributed to increased detection because the results are all based on population surveys using the same detection technique.&rdquo; </p> <div class="figure"><a href="/web/20131105185104/http://www.healio.com/~/media/News/Print/Cardiology Today/2013/10_October/10_3928_1081_597x_20130101_00_1313999/Schneider_Peter.jpg"><img name="/~/media/News/Print/Cardiology Today/2013/10_October/10_3928_1081_597x_20130101_00_1313999/Schneider_Peter.jpg" alt="Peter Schneider" src="/web/20131105185104im_/http://www.healio.com/cardiology/vascular-medicine/news/print/cardiology-today/%7B03effe2f-98c6-4f1c-b394-bbf3c0dcce85%7D/~/media/News/Print/Cardiology Today/2013/10_October/10_3928_1081_597x_20130101_00_1313999/Schneider_Peter.jpg"/></a> <p class="figcaption">Peter Schneider</p> </div> <p>More likely, according to the experts, is that PAD was always prevalent but, because of shorter lifespans, symptoms did not present before death as often in earlier generations. &ldquo;I cannot prove this, but this population with PAD in an earlier generation might have died young of heart disease,&rdquo; Schneider said. &ldquo;With better medical management [and intervention techniques], you have this whole population that has lived for many years with all the risk factors for cardiovascular death. In the United States, the cardiovascular mortality rates have dropped significantly, and a lot of those people who would have passed away in a previous generation are now turning up with these signs and symptoms of atherosclerosis in other beds.&rdquo; </p> <p>Fowkes agreed, citing better survival rates for MI and stroke in high-income countries and better survival rates for infectious diseases in low- and middle-income countries. </p> </div> <!-- figure --> <div class="fig left"> <p class="figcaption"> </p> </div> <div class="wyPagination"> <!-- pagination --> <div id="layout_0_maincontent_1_pagination_divPagination" class="pagination"> <ul> <li> <a class="current page" href="/web/20131105185104/http://www.healio.com/cardiology/vascular-medicine/news/print/cardiology-today/{03effe2f-98c6-4f1c-b394-bbf3c0dcce85}/pad-widely-prevalent-consequences-could-be-dire?Filter=&amp;page=0"> 1 </a> </li> <li> <a class="page" href="/web/20131105185104/http://www.healio.com/cardiology/vascular-medicine/news/print/cardiology-today/{03effe2f-98c6-4f1c-b394-bbf3c0dcce85}/pad-widely-prevalent-consequences-could-be-dire?Filter=&amp;page=1"> 2 </a> </li> <li> <a class="page" href="/web/20131105185104/http://www.healio.com/cardiology/vascular-medicine/news/print/cardiology-today/{03effe2f-98c6-4f1c-b394-bbf3c0dcce85}/pad-widely-prevalent-consequences-could-be-dire?Filter=&amp;page=2"> 3 </a> </li> <li> <a class="page" href="/web/20131105185104/http://www.healio.com/cardiology/vascular-medicine/news/print/cardiology-today/{03effe2f-98c6-4f1c-b394-bbf3c0dcce85}/pad-widely-prevalent-consequences-could-be-dire?Filter=&amp;page=3"> 4 </a> </li> <li> <a class="page" href="/web/20131105185104/http://www.healio.com/cardiology/vascular-medicine/news/print/cardiology-today/{03effe2f-98c6-4f1c-b394-bbf3c0dcce85}/pad-widely-prevalent-consequences-could-be-dire?Filter=&amp;page=4"> 5 </a> </li> </ul> </div> <!-- /pagination --> </div> <!-- /figure --> <div class="follow"> <img src="/web/20131105185104im_/http://www.healio.com/~/media/Images/News/FollowUs.jpg" id="layout_0_maincontent_1_SocialFollow_socialfollow" name="socialfollow" alt="Follow us" usemap="#followus" border="0"/> <map id="followus" name="followus"> <area id="layout_0_maincontent_1_SocialFollow_followfb" shape="rect" coords="51,5,5,51" target="_blank" href="https://web.archive.org/web/20131105185104/http://www.facebook.com/cardiologytoday" alt="Follow us on Facebook"></area> <area id="layout_0_maincontent_1_SocialFollow_followtw" shape="rect" coords="270,3,320,50" target="_blank" href="https://web.archive.org/web/20131105185104/http://www.twitter.com/cardiologytoday" alt="Follow us on Twitter"></area> </map> </div> </div> <!-- /content --> <div class="social-links"> <div class="fb-like" data-send="false" data-width="300" data-show-faces="true" data-action="recommend"></div> <ul class="share"> <li><a href="javascript:void(0)" id="twitter" class="twitter-link" target="_new">Tweet</a></li> <li><a href="javascript:void(0)" id="facebook" class="facebook-link" target="_new">Share</a></li> <li class="linkedin"><a href="javascript:void(0)" id="linkedin" class="linkedin-link">Link</a></li> <li><span class="db-wrapper"><span class="g-plusone" data-size="tall" data-annotation="none"></span></span></li> <li><a href="javascript:void(0)" id="email">Email</a></li> <li class="last"><a href="javascript:void(0)" id="print">Print</a></li> </ul> <input name="layout_0$maincontent_1$SocialMedia$articleItemForTweet" type="hidden" id="layout_0_maincontent_1_SocialMedia_articleItemForTweet" value="{03EFFE2F-98C6-4F1C-B394-BBF3C0DCCE85}"/> <input name="layout_0$maincontent_1$SocialMedia$tweettext" type="hidden" id="layout_0_maincontent_1_SocialMedia_tweettext" class="tweettext" value="PAD widely prevalent, consequences could be dire "/> <input name="layout_0$maincontent_1$SocialMedia$tweeturl" type="hidden" id="layout_0_maincontent_1_SocialMedia_tweeturl" class="tweeturl" value="http://goo.gl/fjUe9g"/> </div> <!-- comment form --> <div id="respond"> <h4> Comments</h4> <script language="javascript" type="text/javascript"> var idcomments_acct = 'aa6ff53f9870e40f92f83e1b5df3cddf'; var idcomments_post_id = '{03EFFE2F-98C6-4F1C-B394-BBF3C0DCCE85}'; var idcomments_post_url; </script> <span id="IDCommentsPostTitle" style="display: none"></span> <script type="text/javascript" src="https://web.archive.org/web/20131105185104js_/http://www.intensedebate.com/js/genericCommentWrapperV2.js"></script> <p class="comment-notes"> Healio is intended for health care provider use and all comments will be posted at the discretion of the editors. 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