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rs2910164 polymorphism</title> <meta name="description" content="Search results for: miR-146a rs2910164 polymorphism"> <meta name="keywords" content="miR-146a rs2910164 polymorphism"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="miR-146a rs2910164 polymorphism"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 253</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: miR-146a rs2910164 polymorphism</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">253</span> Association of MIR146A rs2910164 Variation with a Predisposition to Sporadic Breast Cancer in a Pakistani Cohort</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mushtaq%20Ahmad">Mushtaq Ahmad</a>, <a href="https://publications.waset.org/abstracts/search?q=Bashir%20Rahman"> Bashir Rahman</a>, <a href="https://publications.waset.org/abstracts/search?q=Taqweem-ul-Haq"> Taqweem-ul-Haq</a>, <a href="https://publications.waset.org/abstracts/search?q=Fazal%20Jalil"> Fazal Jalil</a>, <a href="https://publications.waset.org/abstracts/search?q=Aftab%20Ali%20Shah"> Aftab Ali Shah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Single nucleotide polymorphisms (SNPs) in genes coding for microRNAs (miRNAs) play a pivotal role in the progression of breast cancer (BC). We investigated the association of miR-146a rs2910164 G/C polymorphism with the risk of BC in the Pakistani population. The miR-146a rs2910164 polymorphism was genotyped in 300 BC-cases and 300 age- and gender-matched healthy controls using T-ARMS-PCR. Genotype and allele frequencies were calculated, and the association between genotypes and the risk of BC was calculated by odds ratios (OR) and confidence intervals (95%). A significant difference in genotypic frequencies (χ2=63.10; p ≤ 0.0001) and allelic frequencies (OR=0.3955 (0.3132-0.4993); p ≤ 0.0001) was observed between cases and controls. Furthermore, we also found that miR-146 rs2910164 CC homozygote increased the risk of breast cancer in the dominant (OR=0.2397 (0.1629-0.3526); p=0.0001; GG vs GC+CC) and recessive (OR=2.803 (1.865- 4.213); P ≤ 0.0001; CC vs GC+GG) inheritance models. In summary, miR-146a rs2910164 G/C is significantly associated with BC in the Pakistani population. To our knowledge, this is the first study that assessed MIR146a rs2910164 G > C SNP in Pakistani population. By analyzing the secondary structure of MIR146A variant, a significant structural modification was noted. Study with a larger sample size is needed to further confirm these findings. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=MIR146A" title=" MIR146A"> MIR146A</a>, <a href="https://publications.waset.org/abstracts/search?q=microRNA" title=" microRNA"> microRNA</a>, <a href="https://publications.waset.org/abstracts/search?q=SNP" title=" SNP"> SNP</a> </p> <a href="https://publications.waset.org/abstracts/106333/association-of-mir146a-rs2910164-variation-with-a-predisposition-to-sporadic-breast-cancer-in-a-pakistani-cohort" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/106333.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">136</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">252</span> Investigation p53 Codon 72 Polymorphism and miR-146a rs2910164 Polymorphism in Breast Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marjan%20Moradi%20Fard">Marjan Moradi Fard</a>, <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Rassi"> Hossein Rassi</a>, <a href="https://publications.waset.org/abstracts/search?q=Masoud%20Houshmand"> Masoud Houshmand </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: Breast cancer is one of the most common cancers affecting the morbidity and mortality of Iranian women. This disease is a result of collective alterations of oncogenes and tumor suppressor genes. Studies have produced conflicting results concerning the role of p53 codon 72 polymorphism (G>C) and miR-146a rs2910164 polymorphism (G>C) on the risk of several cancers; therefore, a research was performed to estimate the association between the p53 codon 72 polymorphism and miR-146a rs2910164 polymorphism in breast cancer. Methods and Materials: A total of 45 archival breast cancer samples from khatam hospital and 40 healthy samples were collected. Verification of each cancer reported in a relative was sought through the pathology reports of the hospital records. Then, DNA extracted from all samples by standard methods and p53 codon 72 polymorphism genotypes and miR-146a rs2910164 polymorphism genotypes were analyzed using multiplex PCR. The tubules, mitotic activity, necrosis, polymorphism and grade of breast cancer were staged by Nottingham histological grading and immunohistochemical staining of the sections from the paraffin wax embedded tissues for the expression of ER, PR and p53 was carried out using a standard method. Finally, data analysis was performed using the 7 version of the Epi Info(TM) 2012 software and test chi-square(x2) for trend. Results: Successful DNA extraction was assessed by PCR amplification of b-actin gene (99 bp). According to the results, p53 GG genotype and miR-146a rs2910164 CC genotype was significantly associated with increased risk of breast cancer in the study population. In this study, we established that tumors of p53 GG genotype and miR-146a rs2910164 CC genotype exhibited higher mitotic activity, higher polymorphism, lower necrosis, lower tubules, higher ER- and PR-negatives and lower TP53-positives than the other genotypes. Conclusion: The present study provided preliminary evidence that a p53 GG genotype may effect breast cancer risk in the study population, interacting synergistically with miR-146a rs2910164 CC genotype. Our results demonstrate that the testing of p53 codon 72 polymorphism genotypes and miR-146a rs2910164 polymorphism genotypes in combination with clinical parameters can serve as major risk factors in the early identification of breast cancers. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=p53%20codon%2072%20polymorphism" title=" p53 codon 72 polymorphism"> p53 codon 72 polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=miR-146a%20rs2910164%20polymorphism" title=" miR-146a rs2910164 polymorphism"> miR-146a rs2910164 polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=genotypes" title=" genotypes "> genotypes </a> </p> <a href="https://publications.waset.org/abstracts/28547/investigation-p53-codon-72-polymorphism-and-mir-146a-rs2910164-polymorphism-in-breast-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28547.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">336</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">251</span> Role of P53 Codon 72 Polymorphism and miR-146a Rs2910164 Polymorphism in Breast Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marjan%20Moradi%20fard">Marjan Moradi fard</a>, <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Rassi"> Hossein Rassi</a>, <a href="https://publications.waset.org/abstracts/search?q=Masoud%20Houshmand"> Masoud Houshmand</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Aim: Breast cancer is one of the most common cancers affecting the morbidity and mortality of Iranian women. This disease is a result of collective alterations of oncogenes and tumor suppressor genes. Studies have produced conflicting results concerning the role of p53 codon 72 polymorphism (G>C) and miR-146a rs2910164 polymorphism (G>C) on the risk of several cancers; therefore, a research was performed to estimate the association between the p53 codon 72 polymorphism and miR-146a rs2910164 polymorphism in breast cancer. Methods and Materials: A total of 45 archival breast cancer samples from Khatam hospital and 40 healthy samples were collected. Verification of each cancer reported in a relative was sought through the pathology reports of the hospital records. Then, DNA extracted from all samples by standard methods and p53 codon 72 polymorphism genotypes and miR-146a rs2910164 polymorphism genotypes were analyzed using multiplex PCR. The tubules, mitotic activity, necrosis, polymorphism and grade of breast cancer were staged by Nottingham histological grading and immunohistochemical staining of the sections from the paraffin wax embedded tissues for the expression of ER, PR and p53 was carried out using a standard method. Finally, data analysis was performed using the 7 version of the Epi Info(TM) 2012 software and test chi-square(x2) for trend. Results: Successful DNA extraction was assessed by PCR amplification of b-actin gene (99 bp). According to the results, p53 GG genotype and miR-146a rs2910164 CC genotype was significantly associated with increased risk of breast cancer in the study population. In this study, we established that tumors of p53 GG genotype and miR-146a rs2910164 CC genotype exhibited higher mitotic activity, higher polymorphism, lower necrosis, lower tubules, higher ER- and PR-negatives and lower TP53-positives than the other genotypes. Conclusion: The present study provided preliminary evidence that a p53 GG genotype may effect breast cancer risk in the study population, interacting synergistically with miR-146a rs2910164 CC genotype. Our results demonstrate that the testing of p53 codon 72 polymorphism genotypes and miR-146a rs2910164 polymorphism genotypes in combination with clinical parameters can serve as major risk factors in the early identification of breast cancers. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=miR-146a%20rs2910164%20polymorphism" title=" miR-146a rs2910164 polymorphism"> miR-146a rs2910164 polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=p53%20codon%2072%20polymorphism" title=" p53 codon 72 polymorphism"> p53 codon 72 polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=tumors" title=" tumors"> tumors</a>, <a href="https://publications.waset.org/abstracts/search?q=pathology%20reports" title=" pathology reports"> pathology reports</a> </p> <a href="https://publications.waset.org/abstracts/27756/role-of-p53-codon-72-polymorphism-and-mir-146a-rs2910164-polymorphism-in-breast-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/27756.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">371</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">250</span> Association of miRNA146a rs2910164 Polymorphism and Helicobacter pylori Infection in Colorectal Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Zahra%20Solgi">Zahra Solgi</a>, <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Rassi"> Hossein Rassi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Colorectal cancer (CRC) is a multi-step disease, and chronic gastric infection with H. pylori could play a role in one or more of the steps in this pathogenic process. Polymorphisms in several miRNAs are considered to increase the risk for the development of CRC by controlling proliferation, apoptosis and H. pylori pathogenesis. Therefore, the aim of this study was to investigate miRNA146a rs2910164 polymorphism and Helicobacter pylori infection in CRC. A total of 65 patients with CRC were divided into 2 groups: 28 patients < 50 years of age and 37 patients ≥ 50 years of age. DNA was extracted from all samples by a standard method and H. pylori cagA and miRNA146a rs2910164 genotypes were determined by PCR method. The results show that there was no significant difference in the frequency of H. pylori cagA gene between the two groups but there was a significant difference in the distribution of rs2910164 genotypes in patients < 50 years of age with the p-value of 0.05 and odds ratio equal to 2.69. On other hand, patients < 50 years of age with genotype CC of miRNA146a showed a significant difference in CRC risk. Furthermore, there was a significant correlation between rs2910164 CC genotype with Helicobacter pylori infection in patients < 50 years of age. The present study suggests that the CC genotype of miRNA146a in combination with H. pylori infection can be effective as risk factors and molecular markers for early diagnosis and treatment of CRC. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=colorectal%20cancer" title="colorectal cancer">colorectal cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=Helicobacter%20pylori" title=" Helicobacter pylori"> Helicobacter pylori</a>, <a href="https://publications.waset.org/abstracts/search?q=miRNA146a" title=" miRNA146a"> miRNA146a</a>, <a href="https://publications.waset.org/abstracts/search?q=rs2910164%20polymorphism" title=" rs2910164 polymorphism"> rs2910164 polymorphism</a> </p> <a href="https://publications.waset.org/abstracts/96049/association-of-mirna146a-rs2910164-polymorphism-and-helicobacter-pylori-infection-in-colorectal-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/96049.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">152</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">249</span> Role of P53 Codon 72 Polymorphism and Mir-146a Rs2910164 Polymorphism in Cervical Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Rassi">Hossein Rassi</a>, <a href="https://publications.waset.org/abstracts/search?q=Marjan%20Moradi%20Fard"> Marjan Moradi Fard</a>, <a href="https://publications.waset.org/abstracts/search?q=Masoud%20Houshmand"> Masoud Houshmand </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Cervical cancer is multistep disease that is thought to result from an interaction between genetic background and environmental factors. Human papillomavirus (HPV) infection is the leading risk factor for cervical intraepithelial neoplasia (CIN) and cervical cancer. In other hand, some of p53 and miRNA polymorphism may plays an important role in carcinogenesis. This study attempts to clarify the relation of p53 genotypes and miR-146a rs2910164 polymorphism in cervical lesions. Method: Forty two archival samples with cervical lesion retired from Khatam hospital and 40 sample from healthy persons used as control group. A simple and rapid method was used to detect the simultaneous amplification of the HPV consensus L1 region and HPV-16,-18, -11, -31, 33 and -35 along with the b-globin gene as an internal control. We use Multiplex PCR for detection of P53 and miR-146a rs2910164 genotypes in our lab. Finally, data analysis was performed using the 7 version of the Epi Info(TM) 2012 software and test chi-square(x2) for trend. Results: Cervix lesions were collected from 42 patients with Squamous metaplasia, cervical intraepithelial neoplasia, and cervical carcinoma. Successful DNA extraction was assessed by PCR amplification of b-actin gene (99bp). According to the results, p53 GG genotype and miR-146a rs2910164 CC genotype was significantly associated with increased risk of cervical lesions in the study population. In this study, we detected 13 HPV 18 from 42 cervical cancer. Conclusion: The connection between several SNP polymorphism and human virus papilloma in rare researches were seen. The reason of these differences in researches' findings can result in different kinds of races and geographic situations and also differences in life grooves in every region. The present study provided preliminary evidence that a p53 GG genotype and miR-146a rs2910164 CC genotype may effect cervical cancer risk in the study population, interacting synergistically with HPV 18 genotype. Our results demonstrate that the testing of p53 codon 72 polymorphism genotypes and miR-146a rs2910164 polymorphism genotypes in combination with HPV18 can serve as major risk factors in the early identification of cervical cancers. Furthermore, the results indicate the possibility of primary prevention of cervical cancer by vaccination against HPV18 in Iran. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cervical%20cancer" title="cervical cancer">cervical cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=HPV18" title=" HPV18"> HPV18</a>, <a href="https://publications.waset.org/abstracts/search?q=p53%20codon%2072%20polymorphism" title=" p53 codon 72 polymorphism"> p53 codon 72 polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=miR-146a%20rs2910164%20polymorphism" title=" miR-146a rs2910164 polymorphism"> miR-146a rs2910164 polymorphism</a> </p> <a href="https://publications.waset.org/abstracts/27790/role-of-p53-codon-72-polymorphism-and-mir-146a-rs2910164-polymorphism-in-cervical-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/27790.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">456</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">248</span> Investigation p53 and miR-146a rs2910164 Polymorphism in Cervical Lesion</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Rassi">Hossein Rassi</a>, <a href="https://publications.waset.org/abstracts/search?q=Marjan%20Moradi%20fard"> Marjan Moradi fard</a>, <a href="https://publications.waset.org/abstracts/search?q=Masoud%20Houshmand"> Masoud Houshmand</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Cervical cancer is multistep disease that is thought to result from an interaction between genetic background and environmental factors. Human Papillomavirus (HPV) infection is the leading risk factor for Cervical Intraepithelial Neoplasia (CIN) and cervical cancer. In other hand, some of p53 and miRNA polymorphism may plays an important role in carcinogenesis. This study attempts to clarify the relation of p53 genotypes and miR-146a rs2910164 polymorphism in cervical lesions. Method: Forty two archival samples with cervical lesion retired from Khatam hospital and 40 sample from healthy persons used as control group. A simple and rapid method was used to detect the simultaneous amplification of the HPV consensus L1 region and HPV-16,-18, -11, -31, 33, and -35 along with the b-globin gene as an internal control. We use Multiplex PCR for detection of P53 and miR-146a rs2910164 genotypes in our lab. Finally, data analysis was performed using the 7 version of the Epi Info(TM) 2012 software and test chi-square(x2) for trend. Results: Cervix lesions were collected from 42 patients with Squamous metaplasia, cervical intraepithelial neoplasia, and cervical carcinoma. Successful DNA extraction was assessed by PCR amplification of b-actin gene (99 bp). According to the results, p53 GG genotype and miR-146a rs2910164 CC genotype was significantly associated with increased risk of cervical lesions in the study population. In this study, we detected 13 HPV 18 from 42 cervical cancer. Conclusion: The connection between several SNP polymorphism and human virus papilloma in rare researches were seen. The reason of these differences in researches' findings can result in different kinds of races and geographic situations and also differences in life grooves in every region. The present study provided preliminary evidence that a p53 GG genotype and miR-146a rs2910164 CC genotype may effect cervical cancer risk in the study population, interacting synergistically with HPV 18 genotype. Our results demonstrate that the testing of p53 codon 72 polymorphism genotypes and miR-146a rs2910164 polymorphism genotypes in combination with HPV18 can serve as major risk factors in the early identification of cervical cancers. Furthermore, the results indicate the possibility of primary prevention of cervical cancer by vaccination against HPV18 in Iran. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cervical%20cancer" title="cervical cancer">cervical cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=miR-146a%20rs2910164%20polymorphism" title=" miR-146a rs2910164 polymorphism"> miR-146a rs2910164 polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=p53%20polymorphism" title=" p53 polymorphism"> p53 polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=intraepithelial" title=" intraepithelial"> intraepithelial</a>, <a href="https://publications.waset.org/abstracts/search?q=neoplasia" title=" neoplasia"> neoplasia</a>, <a href="https://publications.waset.org/abstracts/search?q=HPV" title=" HPV"> HPV</a> </p> <a href="https://publications.waset.org/abstracts/27789/investigation-p53-and-mir-146a-rs2910164-polymorphism-in-cervical-lesion" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/27789.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">398</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">247</span> Study of Relation between P53 and Mir-146a Rs2910164 Polymorphism in Cervical Lesion</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Rassi">Hossein Rassi</a>, <a href="https://publications.waset.org/abstracts/search?q=Marjan%20Moradi%20Fard"> Marjan Moradi Fard</a>, <a href="https://publications.waset.org/abstracts/search?q=Masoud%20Houshmand"> Masoud Houshmand </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Cervical cancer is multistep disease that is thought to result from an interaction between genetic background and environmental factors. Human papillomavirus (HPV) infection is the leading risk factor for cervical intraepithelial neoplasia(CIN)and cervical cancer. In other hand, some of p53 and miRNA polymorphism may plays an important role in carcinogenesis. This study attempts to clarify the relation of p53 genotypes and miR-146a rs2910164 polymorphism in cervical lesions. Method: Forty two archival samples with cervical lesion retired from Khatam hospital and 40 sample from healthy persons used as control group. A simple and rapid method was used to detect the simultaneous amplification of the HPV consensus L1 region and HPV-16,-18, -11, -31, 33 and -35 along with the b-globin gene as an internal control. We use Multiplex PCR for detection of P53 and miR-146a rs2910164 genotypes in our lab. Finally, data analysis was performed using the 7 version of the Epi Info(TM) 2012 software and test chi-square(x2) for trend. Results: Cervix lesions were collected from 42 patients with Squamous metaplasia, cervical intraepithelial neoplasia, and cervical carcinoma. Successful DNA extraction was assessed by PCR amplification of b-actin gene (99bp). According to the results, p53 GG genotype and miR-146a rs2910164 CC genotype was significantly associated with increased risk of cervical lesions in the study population. In this study, we detected 13 HPV 18 from 42 cervical cancer. Conclusion: The connection between several SNP polymorphism and human virus papilloma in rare researches were seen. The reason of these differences in researches' findings can result in different kinds of races and geographic situations and also differences in life grooves in every region. The present study provided preliminary evidence that a p53 GG genotype and miR-146a rs2910164 CC genotype may effect cervical cancer risk in the study population, interacting synergistically with HPV 18 genotype. Our results demonstrate that the testing of p53 codon 72 polymorphism genotypes and miR-146a rs2910164 polymorphism genotypes in combination with HPV18 can serve as major risk factors in the early identification of cervical cancers. Furthermore, the results indicate the possibility of primary prevention of cervical cancer by vaccination against HPV18 in Iran. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cervical%20cancer" title="cervical cancer">cervical cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=p53" title=" p53"> p53</a>, <a href="https://publications.waset.org/abstracts/search?q=miR-146a" title=" miR-146a"> miR-146a</a>, <a href="https://publications.waset.org/abstracts/search?q=rs2910164" title=" rs2910164"> rs2910164</a>, <a href="https://publications.waset.org/abstracts/search?q=polymorphism" title=" polymorphism "> polymorphism </a> </p> <a href="https://publications.waset.org/abstracts/27788/study-of-relation-between-p53-and-mir-146a-rs2910164-polymorphism-in-cervical-lesion" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/27788.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">468</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">246</span> Investigation Two Polymorphism of hTERT Gene (Rs 2736098 and Rs 2736100) and miR- 146a rs2910164 Polymorphism in Cervical Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Rassi">Hossein Rassi</a>, <a href="https://publications.waset.org/abstracts/search?q=Alaheh%20Gholami%20Roud-Majany"> Alaheh Gholami Roud-Majany</a>, <a href="https://publications.waset.org/abstracts/search?q=Zahra%20Razavi"> Zahra Razavi</a>, <a href="https://publications.waset.org/abstracts/search?q=Massoud%20Hoshmand"> Massoud Hoshmand </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cervical cancer is multi step disease that is thought to result from an interaction between genetic background and environmental factors. Human papillomavirus (HPV) infection is the leading risk factor for cervical intraepithelial neoplasia (CIN)and cervical cancer. In other hand, some of hTERT and miRNA polymorphism may plays an important role in carcinogenesis. This study attempts to clarify the relation of hTERT genotypes and miR-146a genotypes in cervical cancer. Forty two archival samples with cervical lesion retired from Khatam hospital and 40 sample from healthy persons used as control group. A simple and rapid method was used to detect the simultaneous amplification of the HPV consensus L1 region and HPV-16,-18, -11, -31, 33 and -35 along with the b-globin gene as an internal control. We use Multiplex PCR for detection of hTERT and miR-146a rs2910164 genotypes in our lab. Finally, data analysis was performed using the 7 version of the Epi Info(TM) 2012 software and test chi-square(x2) for trend. Cervix lesions were collected from 42 patients with Squamous metaplasia, cervical intraepithelial neoplasia, and cervical carcinoma. Successful DNA extraction was assessed by PCR amplification of b-actin gene (99bp). According to the results, hTERT ( rs 2736098) GG genotype and miR-146a rs2910164 CC genotype was significantly associated with increased risk of cervical cancer in the study population. In this study, we detected 13 HPV 18 from 42 cervical cancer. The connection between several SNP polymorphism and human virus papilloma in rare researches were seen. The reason of these differences in researches' findings can result in different kinds of races and geographic situations and also differences in life grooves in every region. The present study provided preliminary evidence that a p53 GG genotype and miR-146a rs2910164 CC genotype may effect cervical cancer risk in the study population, interacting synergistically with HPV 18 genotype. Our results demonstrate that the testing of hTERT rs 2736098 genotypes and miR-146a rs2910164 genotypes in combination with HPV18 can serve as major risk factors in the early identification of cervical cancers. Furthermore, the results indicate the possibility of primary prevention of cervical cancer by vaccination against HPV18 in Iran. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=polymorphism%20of%20hTERT%20gene" title="polymorphism of hTERT gene">polymorphism of hTERT gene</a>, <a href="https://publications.waset.org/abstracts/search?q=miR-146a%20rs2910164%20polymorphism" title=" miR-146a rs2910164 polymorphism"> miR-146a rs2910164 polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=cervical%20cancer" title=" cervical cancer"> cervical cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=virus" title=" virus"> virus</a> </p> <a href="https://publications.waset.org/abstracts/28545/investigation-two-polymorphism-of-htert-gene-rs-2736098-and-rs-2736100-and-mir-146a-rs2910164-polymorphism-in-cervical-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28545.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">321</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">245</span> Angiotensin Converting Enzyme Gene Polymorphism Studies: A Case-Control Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Salina%20Y.%20Saddick">Salina Y. Saddick</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Mild gestational hyperglycemia (MGH) is a very common complication of pregnancy that is characterized by intolerance to glucose. The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism to MGH has been previously reported. In this study, we evaluated the association between ACE polymorphism and the risk of MGH in a Saudi population. We conducted a case-control study in a population of 100 MGH patients and 100 control subjects. ACE gene polymorphism was analyzed by the novel approach of tetraprimer amplification refractory mutation system (ARMS)-polymerase chain reaction (PCR). The frequency of ACE polymorphism was not associated with either alleles or genotypes in MGH patients. Glucose concentration was found to be significantly associated with the MGH group. Our study suggests that ACE genotypes were not associated with ACE polymorphism in a Saudi population. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=MGH" title="MGH">MGH</a>, <a href="https://publications.waset.org/abstracts/search?q=ACE" title=" ACE"> ACE</a>, <a href="https://publications.waset.org/abstracts/search?q=insertion%20polymorphism" title=" insertion polymorphism"> insertion polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=deletion%20polymorphism" title=" deletion polymorphism"> deletion polymorphism</a> </p> <a href="https://publications.waset.org/abstracts/38316/angiotensin-converting-enzyme-gene-polymorphism-studies-a-case-control-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/38316.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">319</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">244</span> Detection of Polymorphism of Growth Hormone Gene in Holstein Cattle</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Emine%20%C5%9Eahin">Emine Şahin</a>, <a href="https://publications.waset.org/abstracts/search?q=Murat%20Soner%20Balc%C4%B1o%C4%9Flu"> Murat Soner Balcıoğlu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this study was to determine the growth hormone (bGH) gene polymorphism in the Holstein cattle growing around Antalya in Turkey. In order to determine the bGH-AluI polymorphism, polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method was performed. A 891 bp fragment of bGH was amplified and two types of alleles C and D for bGH were observed. In this study, the frequencies of C and D alleles were 0.8438 and 0.1562, respectively. The genotype frequencies for CC, CD and DD were 0.787, 0.191 and 0.022, respectively. According to the results of the chi-square test, a significant deviation from the Hardy-Weinberg equilibrium was not determined for the bGH locus in the population. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Growth%20Hormone%20Gene" title="Growth Hormone Gene">Growth Hormone Gene</a>, <a href="https://publications.waset.org/abstracts/search?q=Holstein" title=" Holstein "> Holstein </a>, <a href="https://publications.waset.org/abstracts/search?q=Polymorphism" title=" Polymorphism"> Polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=RFLP" title=" RFLP"> RFLP</a> </p> <a href="https://publications.waset.org/abstracts/63845/detection-of-polymorphism-of-growth-hormone-gene-in-holstein-cattle" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/63845.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">371</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">243</span> Analysis of OPG Gene Polymorphism T245G (rs3134069) in Slovak Postmenopausal Women</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I.%20Boro%C5%88ov%C3%A1">I. Boroňová</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Bernasovsk%C3%A1"> J. Bernasovská</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20K%C4%BEoc"> J. Kľoc</a>, <a href="https://publications.waset.org/abstracts/search?q=Z.%20Tomkov%C3%A1"> Z. Tomková</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Petrej%C4%8D%C3%ADkov%C3%A1"> E. Petrejčíková</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Ma%C4%8Dekov%C3%A1"> S. Mačeková</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Por%C3%A1%C4%8Dov%C3%A1"> J. Poráčová</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20M.%20Bla%C5%A1%C4%8D%C3%A1kov%C3%A1"> M. M. Blaščáková</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Osteoporosis is a common multifactorial disease with a strong genetic component characterized by reduced bone mass and increased risk of fractures. Genetic factors play an important role in the pathogenesis of osteoporosis. The aim of our study was to identify the genotype and allele distribution of T245G polymorphism in OPG gene in Slovak postmenopausal women. A total of 200 unrelated Slovak postmenopausal women with diagnosed osteoporosis and 200 normal controls were genotyped for T245G (rs3134069) polymorphism of OPG gene. Genotyping was performed using the Custom Taqman®SNP Genotyping assays. Genotypes and alleles frequencies showed no significant differences (p=0.5551; p=0.6022). The results of the present study confirm the importance of T245G polymorphism in OPG gene in the pathogenesis of osteoporosis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=OPG%20gene" title="OPG gene">OPG gene</a>, <a href="https://publications.waset.org/abstracts/search?q=T245G%20polymorphism" title=" T245G polymorphism"> T245G polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=osteoporosis" title=" osteoporosis"> osteoporosis</a>, <a href="https://publications.waset.org/abstracts/search?q=T245G%20polymorphism" title=" T245G polymorphism"> T245G polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=real-time%20PCR" title=" real-time PCR "> real-time PCR </a> </p> <a href="https://publications.waset.org/abstracts/12859/analysis-of-opg-gene-polymorphism-t245g-rs3134069-in-slovak-postmenopausal-women" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/12859.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">409</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">242</span> Association of Xeroderma pigmentosum Group D Gene Polymorphism with Colorectal Cancer Risk in Kashmiri Population</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Syed%20Sameer%20Aga">Syed Sameer Aga</a>, <a href="https://publications.waset.org/abstracts/search?q=Saniya%20Nissar"> Saniya Nissar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The Xeroderma pigmentosum group D gene (XPD) plays a key role in nucleotide excision repair (NER) pathway of the damaged DNA. Genetic polymorphisms in the coding region of the XPD gene may alter DNA repair capacity of the protein and hence can modulate the risk of colorectal cancer (CRC) risk. The aim of the study was to determine the genetic association of XPD Lys751Gln polymorphism with the risk of colorectal cancer (CRC) development. 120 CRC patients and 160 normal controls were assessed for genotype frequencies of XPD Lys751Gln polymorphism using PCR-RFLP technique. We observed a significant association (p < 0.05) between the XPD Lys751Gln polymorphism and the risk of developing CRC (p < 0.05). Additionally, Gln/Gln genotype of the XPD gene doubled the risk for the development of CRC [p < 0.05; OR=2.25 95% CI (1.07-4.7)]. Our results suggest that there is a significant association between the XPD Lys751Gln polymorphism and the risk of CRC. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=colorectal%20cancer" title="colorectal cancer">colorectal cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=polymorphism" title=" polymorphism"> polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=RFLP" title=" RFLP"> RFLP</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20Repair" title=" DNA Repair"> DNA Repair</a>, <a href="https://publications.waset.org/abstracts/search?q=NER" title=" NER"> NER</a>, <a href="https://publications.waset.org/abstracts/search?q=XPD" title=" XPD"> XPD</a> </p> <a href="https://publications.waset.org/abstracts/105947/association-of-xeroderma-pigmentosum-group-d-gene-polymorphism-with-colorectal-cancer-risk-in-kashmiri-population" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/105947.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">216</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">241</span> RAPD Analysis of the Genetic Polymorphism in the Collection of Rye Cultivars </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=L.%20Petrovi%C4%8Dov%C3%A1">L. Petrovičová</a>, <a href="https://publications.waset.org/abstracts/search?q=%C5%BD.%20Bal%C3%A1%C5%BEov%C3%A1"> Ž. Balážová</a>, <a href="https://publications.waset.org/abstracts/search?q=Z.%20G%C3%A1lov%C3%A1"> Z. Gálová</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20W%C3%B3jcik-Jag%C5%82a"> M. Wójcik-Jagła</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Rapacz"> M. Rapacz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the present study, RAPD-PCR was used to assess genetic diversity of the rye including landrances and new rye cultivars coming from Central Europe and the Union of Soviet Socialist Republics (SUN). Five arbitrary random primers were used to determine RAPD polymorphism in the set of 38 rye genotypes. These primers amplified altogether 43 different DNA fragments with an average number of 8.6 fragments per genotypes. The number of fragments ranged from 7 (RLZ 8, RLZ 9 and RLZ 10) to 12 (RLZ 6). DI and PIC values of all RAPD markers were higher than 0.8 that generally means high level of polymorphism detected between rye genotypes. The dendrogram based on hierarchical cluster analysis using UPGMA algorithm was prepared. The cultivars were grouped into two main clusters. In this experiment, RAPD proved to be a rapid, reliable and practicable method for revealing of polymorphism in the rye cultivars. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=genetic%20diversity" title="genetic diversity">genetic diversity</a>, <a href="https://publications.waset.org/abstracts/search?q=polymorphism" title=" polymorphism"> polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=RAPD%20markers" title=" RAPD markers"> RAPD markers</a>, <a href="https://publications.waset.org/abstracts/search?q=Secale%20cereale%20L." title=" Secale cereale L."> Secale cereale L.</a> </p> <a href="https://publications.waset.org/abstracts/6448/rapd-analysis-of-the-genetic-polymorphism-in-the-collection-of-rye-cultivars" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/6448.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">444</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">240</span> Identification of Mx Gene Polymorphism in Indragiri Hulu duck by PCR-RFLP</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Restu%20Misrianti">Restu Misrianti</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The amino acid variation of Asn (allele A) at position 631 in Mx gene was specific to positive antiviral to avian viral desease. This research was aimed at identifying polymorphism of Mx gene in duck using molecular technique. Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) technique was used to select the genotype of AA, AG and GG. There were thirteen duck from Indragiri Hulu regency (Riau Province) used in this experiment. DNA amplification results showed that the Mx gene in duck is found in a 73 bp fragment. Mx gene in duck did not show any polymorphism. The frequency of the resistant allele (AA) was 0%, while the frequency of the susceptible allele (GG) was 100%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=duck" title="duck">duck</a>, <a href="https://publications.waset.org/abstracts/search?q=Mx%20gene" title=" Mx gene"> Mx gene</a>, <a href="https://publications.waset.org/abstracts/search?q=PCR" title=" PCR"> PCR</a>, <a href="https://publications.waset.org/abstracts/search?q=RFLP" title=" RFLP"> RFLP</a> </p> <a href="https://publications.waset.org/abstracts/37764/identification-of-mx-gene-polymorphism-in-indragiri-hulu-duck-by-pcr-rflp" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37764.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">324</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">239</span> Cognitive Weighted Polymorphism Factor: A New Cognitive Complexity Metric</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=T.%20Francis%20Thamburaj">T. Francis Thamburaj</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Aloysius"> A. Aloysius</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Polymorphism is one of the main pillars of the object-oriented paradigm. It induces hidden forms of class dependencies which may impact software quality, resulting in higher cost factor for comprehending, debugging, testing, and maintaining the software. In this paper, a new cognitive complexity metric called Cognitive Weighted Polymorphism Factor (CWPF) is proposed. Apart from the software structural complexity, it includes the cognitive complexity on the basis of type. The cognitive weights are calibrated based on 27 empirical studies with 120 persons. A case study and experimentation of the new software metric shows positive results. Further, a comparative study is made and the correlation test has proved that CWPF complexity metric is a better, more comprehensive, and more realistic indicator of the software complexity than Abreu’s Polymorphism Factor (PF) complexity metric. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cognitive%20complexity%20metric" title="cognitive complexity metric">cognitive complexity metric</a>, <a href="https://publications.waset.org/abstracts/search?q=object-oriented%20metrics" title=" object-oriented metrics"> object-oriented metrics</a>, <a href="https://publications.waset.org/abstracts/search?q=polymorphism%20factor" title=" polymorphism factor"> polymorphism factor</a>, <a href="https://publications.waset.org/abstracts/search?q=software%20metrics" title=" software metrics"> software metrics</a> </p> <a href="https://publications.waset.org/abstracts/36961/cognitive-weighted-polymorphism-factor-a-new-cognitive-complexity-metric" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/36961.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">458</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">238</span> The Distribution of rs5219 Polymorphism in the Non-Diabetic Elderly Jordanian Subject</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Foad%20Alzoughool">Foad Alzoughool</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Conflicting studies on the association between the rs5219 polymorphism and type 2 diabetes, some studies have confirmed a strong relationship between this variant and type2 diabetes, on the other hand, many studies denied the existence of this association. This study aimed to provide evidence about whether the rs5219 polymorphism has or hasn't a role as a risk factor for diabetes and meta-analysis to investigate the role of the control age group in the association. Genotyping of the rs5219 polymorphism was performed in a cohort of 266 healthy elderly subjects with a mean age (60.2 ± 5.1) with no history of diabetes (HbA1c < 6%) using standard Sanger sequencing methods. Lys/Lys alleles were detected in 20 persons (7.5%), Lys/Glu alleles in 96 persons (36.1%), and Glu/Glu in 150 persons (56.4%). The genotype distribution was consistent with Hardy–Weinberg equilibrium (P =0.7). Meta-analysis notably indicates no association between rs5219 polymorphism and type 2 diabetes in all studies used the younger age of the control group compared to the patient's age. In conclusion, our study sheds light on the importance of age factor among the control group recruited in case-control studies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Type%202%20diabetes" title="Type 2 diabetes">Type 2 diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=rs5219%20polymorphism" title=" rs5219 polymorphism"> rs5219 polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=E23K" title=" E23K"> E23K</a>, <a href="https://publications.waset.org/abstracts/search?q=KCNJ11%20gene" title=" KCNJ11 gene"> KCNJ11 gene</a> </p> <a href="https://publications.waset.org/abstracts/123613/the-distribution-of-rs5219-polymorphism-in-the-non-diabetic-elderly-jordanian-subject" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/123613.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">159</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">237</span> Showing Broccoli and Cabbage Genotypes Biodiversity Using Randomly Amplified Polymorphic DNAs (RAPD)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20M.%20A.%20Abdalla">M. M. A. Abdalla</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20H.%20Aboul-Nasr"> M. H. Aboul-Nasr</a>, <a href="https://publications.waset.org/abstracts/search?q=Shimaa%20H.%20Mosallam"> Shimaa H. Mosallam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ten RAPD markers were used to detect the genetic variability and relationships among four broccoli and three cabbage genotypes. The results of RAPD analysis showed that all the five primers surveyed detected polymorphism for all broccoli genotypes. A total of 39 DNA bands were amplified by the 5 primers from all genotype and 21 of these fragments showed polymorphism (53.85%). The rest of these bands (46.15%) were common between the four genotypes. On the other hand, all of the 7 primers surveyed, used with cabbage, detected polymorphism among all cabbage genotype. A total of 69 DNA bands were amplified by the 7 primers from all genotypes and 23 of these fragments showed polymorphism (33.33%). The rest of these bands (66.67%) were common between the three genotypes. The investigation suggested that the RAPD approach showed considerable potential for identifying and discriminating broccoli and cabbage genotypes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Brassica%20oleracea" title="Brassica oleracea">Brassica oleracea</a>, <a href="https://publications.waset.org/abstracts/search?q=genotypes" title=" genotypes"> genotypes</a>, <a href="https://publications.waset.org/abstracts/search?q=genetic%20markers" title=" genetic markers"> genetic markers</a>, <a href="https://publications.waset.org/abstracts/search?q=varietal%20identification" title=" varietal identification"> varietal identification</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20polymorphism" title=" DNA polymorphism"> DNA polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=RAPD%20markers" title=" RAPD markers"> RAPD markers</a> </p> <a href="https://publications.waset.org/abstracts/40295/showing-broccoli-and-cabbage-genotypes-biodiversity-using-randomly-amplified-polymorphic-dnas-rapd" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40295.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">320</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">236</span> CAG Repeat Polymorphism of Androgen Receptor and Female Sexual Functions in Egyptian Female Population</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Azza%20Gaber%20Farag">Azza Gaber Farag</a>, <a href="https://publications.waset.org/abstracts/search?q=Yasser%20Atta%20Shehata"> Yasser Atta Shehata</a>, <a href="https://publications.waset.org/abstracts/search?q=Sara%20Elsayed%20Elghazouly"> Sara Elsayed Elghazouly</a>, <a href="https://publications.waset.org/abstracts/search?q=Mustafa%20Elsayed%20Elshaib"> Mustafa Elsayed Elshaib</a>, <a href="https://publications.waset.org/abstracts/search?q=Nesreen%20Gamal%20Elden%20Elhelbawy"> Nesreen Gamal Elden Elhelbawy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Androgen receptor (AR) polymorphism in cytosine adenineguanine (CAG) repeat has an effect on the functional capacity of AR in males. However, little researches in this field are available regarding female sexual function. Aim: To investigate the possible link between polymorphism in the CAG repeat of AR gene and female sexual function in a sample of the Egyptian population. Materials and methods: 500 Egyptian married females completed a questionnaire regarding sociodemographic, reproductive, and sexual data. AR CAG repeat length was analyzed for those having female sexual dysfunctions (FSD) using real-time PCR. Results: The most sensitive domain to AR CAG repeat length was the orgasm domain that showed significant positive correlations with short allele (p=0.001), long allele (p=.015), biallellic mean (p=.000), and X weighted biallelic mean (p=.000). The satisfaction domain had significant positive correlations with the biallelic mean (p=.035), and the X weighted biallelic mean (p=. 032). However, the pain domain was of significant negative correlations with AR polymorphism of short allele (p=.002), biallelic mean (p=.013), and X weighted biallelic mean (p = . 011). Conclusions: AR polymorphism could represent a non-negligible aspect in female sexual function. The lower AR CAG repeat polymorphism was of significant impact on FSD, affecting mainly female orgasm followed by pain disorders that finally reflected On her sexual satisfaction. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=female%20sexual%20dysfunction" title="female sexual dysfunction">female sexual dysfunction</a>, <a href="https://publications.waset.org/abstracts/search?q=androgen%20receptor" title=" androgen receptor"> androgen receptor</a>, <a href="https://publications.waset.org/abstracts/search?q=CAG%20repeat%20polymorphism" title=" CAG repeat polymorphism"> CAG repeat polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=androgen" title=" androgen"> androgen</a> </p> <a href="https://publications.waset.org/abstracts/142676/cag-repeat-polymorphism-of-androgen-receptor-and-female-sexual-functions-in-egyptian-female-population" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/142676.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">182</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">235</span> ZBTB17 Gene rs10927875 Polymorphism in Slovak Patients with Dilated Cardiomyopathy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I.%20Boro%C5%88ov%C3%A1">I. Boroňová</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Bernasovsk%C3%A1"> J. Bernasovská</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Kmec"> J. Kmec</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Petrej%C4%8D%C3%ADkov%C3%A1"> E. Petrejčíková</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Dilated cardiomyopathy (DCM) is a severe cardiovascular disorder characterized by progressive systolic dysfunction due to cardiac chamber dilatation and inefficient myocardial contractility often leading to chronic heart failure. Recently, a genome-wide association studies (GWASs) on DCM indicate that the ZBTB17 gene rs10927875 single nucleotide polymorphism is associated with DCM. The aim of the study was to identify the distribution of ZBTB17 gene rs10927875 polymorphism in 50 Slovak patients with DCM and 80 healthy control subjects using the Custom Taqman®SNP Genotyping assays. Risk factors detected at baseline in each group included age, sex, body mass index, smoking status, diabetes and blood pressure. The mean age of patients with DCM was 52.9±6.3 years; the mean age of individuals in control group was 50.3±8.9 years. The distribution of investigated genotypes of rs10927875 polymorphism within ZBTB17 gene in the cohort of Slovak patients with DCM was as follows: CC (38.8%), CT (55.1%), TT (6.1%), in controls: CC (43.8%), CT (51.2%), TT (5.0%). The risk allele T was more common among the patients with dilated cardiomyopathy than in normal controls (33.7% versus 30.6%). The differences in genotype or allele frequencies of ZBTB17 gene rs10927875 polymorphism were not statistically significant (p=0.6908; p=0.6098). The results of this study suggest that ZBTB17 gene rs10927875 polymorphism may be a risk factor for susceptibility to DCM in Slovak patients with DCM. Studies of numerous files and additional functional investigations are needed to fully understand the roles of genetic associations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ZBTB17%20gene" title="ZBTB17 gene">ZBTB17 gene</a>, <a href="https://publications.waset.org/abstracts/search?q=rs10927875%20polymorphism" title=" rs10927875 polymorphism"> rs10927875 polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=dilated%20cardiomyopathy" title=" dilated cardiomyopathy"> dilated cardiomyopathy</a>, <a href="https://publications.waset.org/abstracts/search?q=cardiovascular%20disorder" title=" cardiovascular disorder"> cardiovascular disorder</a> </p> <a href="https://publications.waset.org/abstracts/12860/zbtb17-gene-rs10927875-polymorphism-in-slovak-patients-with-dilated-cardiomyopathy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/12860.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">405</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">234</span> Deleterious SNP’s Detection Using Machine Learning</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hamza%20Zidoum">Hamza Zidoum</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper investigates the impact of human genetic variation on the function of human proteins using machine-learning algorithms. Single-Nucleotide Polymorphism represents the most common form of human genome variation. We focus on the single amino-acid polymorphism located in the coding region as they can affect the protein function leading to pathologic phenotypic change. We use several supervised Machine Learning methods to identify structural properties correlated with increased risk of the missense mutation being damaging. SVM associated with Principal Component Analysis give the best performance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=single-nucleotide%20polymorphism" title="single-nucleotide polymorphism">single-nucleotide polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=machine%20learning" title=" machine learning"> machine learning</a>, <a href="https://publications.waset.org/abstracts/search?q=feature%20selection" title=" feature selection"> feature selection</a>, <a href="https://publications.waset.org/abstracts/search?q=SVM" title=" SVM"> SVM</a> </p> <a href="https://publications.waset.org/abstracts/45046/deleterious-snps-detection-using-machine-learning" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/45046.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">377</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">233</span> Effect of Functional Group Position in Co-Formers and Solvent on Cocrystal Polymorphism/Stoichiomorphism: A Case Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Luguang%20Qi">Luguang Qi</a>, <a href="https://publications.waset.org/abstracts/search?q=Chuang%20Xie"> Chuang Xie</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In recent years, there has been an increase in the number of reports on cocrystal polymorphism and stoichiomorphism. However, the research on the factors that influence these phenomena is limited. Herein, picolinamide (PAM), nicotinamide (NAM), and isonicotinamide (INA) were selected as co-formers to form multicomponent solids with 4-chloro-3-sulfamoylbenzoic acid (CSBA). Six new cocrystal forms of CSBA were discovered, and their crystal structures were determined. It was found that PAM and NAM can only form one cocrystal with CSBA, while INA can form up to four cocrystals, including both cocrystal polymorphism and stoichiomorphism. Molecular electrostatic potential analysis and crystal structure analysis showed that the functional group position of PAM limited the diversity of cocrystal synthons, while the lattice energy limited the diversity of cocrystal synthons when NAM acted as a co-former. Only INA was not subject to these restrictions when forming cocrystals. Finally, the influence of solvents on cocrystals was illustrated by determining the ternary phase diagrams. The mechanism of two similar solvents, ethyl acetate, and acetone, controlling the crystallization of cocrystal polymorphism was analyzed by molecular simulations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cocrystal%20polymorphism" title="cocrystal polymorphism">cocrystal polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=cocrystal%20stoichiomorphism" title=" cocrystal stoichiomorphism"> cocrystal stoichiomorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=phase%20diagram" title=" phase diagram"> phase diagram</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20simulation" title=" molecular simulation"> molecular simulation</a> </p> <a href="https://publications.waset.org/abstracts/168142/effect-of-functional-group-position-in-co-formers-and-solvent-on-cocrystal-polymorphismstoichiomorphism-a-case-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/168142.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">73</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">232</span> Study of Phenotypic Polymorphism and Detection of Genotypic Polymorphism in Menochilus sexmaculatus (Coleoptera: Insecta) Using RAPD PCR</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Huma%20Balouch">Huma Balouch</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Menochilus sexmaculatus commonly known as six spotted zig zag ladybird, is an aphidophagus and the most misidentified Coccinellids due to the occurrence of numerous color variants. The correct identification of Menochilus sexmaculatus and its strains is necessary to implement the use of biological control. In the present study phenotypic and genotypic polymorphism was investigated in Menochilus sexmaculatus collected from Punjab, NWFP and Sindh provinces of Pakistan. Six different morphs of the species were distinguished by analyzing its Elytral color and spot pattern and then Polymerase Chain Reaction was used to generate random amplification of polymorphic DNA (RAPD) from six different types of Menochilus sexmaculatus. Forty primers (OPA & OPC Kit) were used to perform RAPD PCR on six different types of Menochilus sexmaculatus of which, seven primers revealed different patterns related to the Menochilus sexmaculatus types. These seven primers (OPA-04, OPA-09, OPA-18, OPC-04, OPC-12, OPC-15 and OPC-18) produced 111 clear polymorphic bands and 6 scorable strain specific markers. The cluster analysis applied to RAPD data showed high polymorphism among six types and it can be concluded that these six types are six polymorphic strains of the same species. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Menochilus%20sexmaculatus" title="Menochilus sexmaculatus">Menochilus sexmaculatus</a>, <a href="https://publications.waset.org/abstracts/search?q=aphidophagus" title=" aphidophagus"> aphidophagus</a>, <a href="https://publications.waset.org/abstracts/search?q=coccinellids" title=" coccinellids"> coccinellids</a>, <a href="https://publications.waset.org/abstracts/search?q=phenotypic%20and%20genotypic%20polymorphism" title=" phenotypic and genotypic polymorphism"> phenotypic and genotypic polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=RAPD-PCR" title=" RAPD-PCR"> RAPD-PCR</a>, <a href="https://publications.waset.org/abstracts/search?q=strain%20specific%20markers" title=" strain specific markers"> strain specific markers</a> </p> <a href="https://publications.waset.org/abstracts/9155/study-of-phenotypic-polymorphism-and-detection-of-genotypic-polymorphism-in-menochilus-sexmaculatus-coleoptera-insecta-using-rapd-pcr" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9155.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">494</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">231</span> Polymorphism of Candidate Genes for Meat Production in Lori Sheep </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shahram%20Nanekarania">Shahram Nanekarania</a>, <a href="https://publications.waset.org/abstracts/search?q=Majid%20Goodarzia"> Majid Goodarzia</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Calpastatin and callipyge have been known as one of the candidate genes in meat quality and quantity. Calpastatin gene has been located to chromosome 5 of sheep and callipyge gene has been localized in the telomeric region on ovine chromosome 18. The objective of this study was identification of calpastatin and callipyge genes polymorphism and analysis of genotype structure in population of Lori sheep kept in Iran. Blood samples were taken from 120 Lori sheep breed and genomic DNA was extracted by salting out method. Polymorphism was identified using the PCR-RFLP technique. The PCR products were digested with MspI and FaqI restriction enzymes for calpastatin gene and callipyge gene, respectively. In this population, three patterns were observed and AA, AB, BB genotype have been identified with the 0.32, 0.63, 0.05 frequencies for calpastatin gene. The results obtained for the callipyge gene revealed that only the wild-type allele A was observed, indicating that only genotype AA was present in the population under consideration. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=polymorphism" title="polymorphism">polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=calpastatin" title=" calpastatin"> calpastatin</a>, <a href="https://publications.waset.org/abstracts/search?q=callipyge" title=" callipyge"> callipyge</a>, <a href="https://publications.waset.org/abstracts/search?q=PCR-RFLP" title=" PCR-RFLP"> PCR-RFLP</a>, <a href="https://publications.waset.org/abstracts/search?q=Lori%20sheep" title=" Lori sheep"> Lori sheep</a> </p> <a href="https://publications.waset.org/abstracts/8594/polymorphism-of-candidate-genes-for-meat-production-in-lori-sheep" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8594.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">611</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">230</span> Association of 1565C/T Polymorphism of Integrin Beta-3 (ITGB3) Gene and Increased Risk for Myocardial Infarction in Patients with Premature Coronary Artery Disease among Iranian Population</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mehrdad%20Sheikhvatan">Mehrdad Sheikhvatan</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Ali%20Boroumand"> Mohammad Ali Boroumand</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehrdad%20Behmanesh"> Mehrdad Behmanesh</a>, <a href="https://publications.waset.org/abstracts/search?q=Shayan%20Ziaee"> Shayan Ziaee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Contradictory results have been obtained regarding the role of integrin, beta 3 (ITGB3) gene polymorphisms in occurrence of acute myocardial infarction (MI) in patients with coronary artery disease (CAD). Hence, we aimed to assess the association between 1565C/T polymorphism of ITGB3 gene and increased risk for acute MI in patients who suffered premature CAD in Iranian population. Our prospective study included 1000 patients (492 men and 508 women aged 21 to 55 years) referred to Tehran Heart center during a period of four years from 2008 to 2011 with the final diagnosis of premature CAD and classified into two groups with history of MI (n = 461) and without of MI (n = 539). The polymorphism variants were determined by PCR-RFLP technique by entering 10% of randomized samples and then genotyping of the polymorphism was also conducted by High Resolution Melting (HRM) method. Among study samples, 640 were followed with a median follow-up time 45.74 months for determining association of long-term major adverse cardiac events (MACE) and genotypes of polymorphisms. There was no significant difference in the frequency of 1565C/T polymorphism between the MI and non-MI groups. The frequency of wild genotype was 69.2% and 72.2%, the frequency of homozygous genotype was 21.3% and 18.4%, and the frequency of mutant genotype was 9.5% and 9.5%, respectively (p=0.505). Results were also similar when adjusted for covariates in a multivariate logistic regression model. No significant difference was also found in total-MACE free survival rate between the patients with different genotypes of 1565C/T polymorphism in both MI and non-MI group. The carriage of the 1565C/T polymorphism of ITGB3 gene seems unlikely to be a significant risk factor for the development of MI in Iranian patients with premature CAD. The presence of this ITGB3 gene polymorphism may not also predict long-term cardiac events. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=coronary%20artery%20disease" title="coronary artery disease">coronary artery disease</a>, <a href="https://publications.waset.org/abstracts/search?q=myocardial%20infarction" title=" myocardial infarction"> myocardial infarction</a>, <a href="https://publications.waset.org/abstracts/search?q=gene" title=" gene"> gene</a>, <a href="https://publications.waset.org/abstracts/search?q=integrin" title=" integrin"> integrin</a>, <a href="https://publications.waset.org/abstracts/search?q=beta%203" title=" beta 3"> beta 3</a>, <a href="https://publications.waset.org/abstracts/search?q=polymorphism" title=" polymorphism"> polymorphism</a> </p> <a href="https://publications.waset.org/abstracts/24248/association-of-1565ct-polymorphism-of-integrin-beta-3-itgb3-gene-and-increased-risk-for-myocardial-infarction-in-patients-with-premature-coronary-artery-disease-among-iranian-population" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24248.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">399</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">229</span> Analysis of Endogenous Sirevirus in Germinating Barley (Hordeum vulgare L.)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nermin%20Gozukirmizi">Nermin Gozukirmizi</a>, <a href="https://publications.waset.org/abstracts/search?q=Buket%20Cakmak"> Buket Cakmak</a>, <a href="https://publications.waset.org/abstracts/search?q=Sevgi%20Marakli"> Sevgi Marakli </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sireviruses are genera of copia LTR retrotransposons with a unique genome structure among retrotransposons. Barley (Hordeum vulgare L.) is an economically important plant and has been studied as a model plant regarding its short annual life cycle and seven chromosome pairs. In this study, we used mature barley embryos, 10-day-old roots and 10-day-old leaves derived from the same barley plant to investigate SIRE1 retrotransposon movements by Inter-Retrotransposon Amplified Polymorphism (IRAP) technique. We found polymorphism rates between 0-64% among embryos, roots and leaves. Polymorphism rates were detected to be 0-27% among embryos, 8-60% among roots, and 11-50% among leaves. Polymorphisms were observed not only among the parts of different individuals, but also on the parts of the same plant (23-64%). The internal domains of SIRE1 (gag, env and rt) were also analyzed in the embryos, roots and leaves. Analysis of band profiles showed no polymorphism for gag, however, different band patterns were observed among samples for rt and env. The sequencing of SIRE1 gag, env and rt domains revealed 79% similarity for gag, 95% for env and 84% for rt to Ty1-copia retrotransposons. SIRE1 retrotransposon was identified in the soybean genome and has been studied on other plants (maize, rice, tomatoe etc.). This study is the first detailed investigation of SIRE1 in barley genome. The obtained findings are expected to contribute to the comprehension of SIRE1 retrotransposon and its role in barley genome. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=barley" title="barley">barley</a>, <a href="https://publications.waset.org/abstracts/search?q=polymorphism" title=" polymorphism"> polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=retrotransposon" title=" retrotransposon"> retrotransposon</a>, <a href="https://publications.waset.org/abstracts/search?q=SIRE1%20virus" title=" SIRE1 virus "> SIRE1 virus </a> </p> <a href="https://publications.waset.org/abstracts/15188/analysis-of-endogenous-sirevirus-in-germinating-barley-hordeum-vulgare-l" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15188.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">308</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">228</span> Association of Gln223Arg Polymorphism of Gene LEPR, Levels of Leptin and Nourishing Habits in Mexican Adolescents with Morbid Obesity </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Claudia%20Patricia%20Beltran%20Miranda">Claudia Patricia Beltran Miranda</a>, <a href="https://publications.waset.org/abstracts/search?q=M%C3%B3nica%20L%C3%B3pez%20Anaya"> Mónica López Anaya</a>, <a href="https://publications.waset.org/abstracts/search?q=M%C3%B3nica%20Navarro%20Meza"> Mónica Navarro Meza</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Leonor%20Valderrama%20Chairez"> Maria Leonor Valderrama Chairez </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Mexico occupies the second world-wide place of morbid obese people (10- 12 million). Factors that predispose the development of MO are genetic, environmental, physiological, psycho-social and behavioral (nourishing habits). Objective: Associate Gln223Arg polymorphism of gene LEPR, levels of leptina and nourishing habits with the presence of morbid obesity in adolescents of the south of Jalisco (México). Methods: In 41 adolescents (18 normal weight and 23 morbid obesity) of 12 to 19 years of age, both sexes that were measure size and weight with tanita scale and stadimeter to determine IMC. Morbid obesity was determined by tables of the WHO and was established with a standard deviation >3. The Gln223Arg polymorphism have been identify by PCR and leptina levels by ELISA. Nourishing habits were evaluate by the questionnaire the Adolescent Food Habits Checklist. The statistical analysis was performed to compare mean scores obtained from the questionnaire when we compare morbid obesity vs. normal weight adolescents with p=0.03 and a significance of 95%. Results: frequencies alellics and genics were not stadistics significatives p= 0,011 and p=0,279 respectly when were compared between normal weight adolescents and morbib obesity Leptin levels and nourishing habits were associated with morbid obesity. The polymorphism not shown significance with morbid obesity. Conclusions: Dietary habits and leptin levels in adolescents are important factor that predisposes the development of obesity in adolescents. The presence of the polymorphism are not associated with morbid obesity in these subjects. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=leptin" title="leptin">leptin</a>, <a href="https://publications.waset.org/abstracts/search?q=nourishing%20habits" title=" nourishing habits"> nourishing habits</a>, <a href="https://publications.waset.org/abstracts/search?q=morbid%20obesity" title=" morbid obesity"> morbid obesity</a>, <a href="https://publications.waset.org/abstracts/search?q=polymorphism" title=" polymorphism"> polymorphism</a> </p> <a href="https://publications.waset.org/abstracts/28023/association-of-gln223arg-polymorphism-of-gene-lepr-levels-of-leptin-and-nourishing-habits-in-mexican-adolescents-with-morbid-obesity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28023.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">573</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">227</span> Postprandial Satiety, Sweets Intake, Physical Activity, and Depressive Symptoms in Relation to Rs9939609 Polymorphism of the FTO Gene</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ma%C5%82gorzata%20Wrzosek">Małgorzata Wrzosek</a>, <a href="https://publications.waset.org/abstracts/search?q=Nina%20Baruch"> Nina Baruch</a>, <a href="https://publications.waset.org/abstracts/search?q=Beata%20Jab%C5%82onowska-Lietz"> Beata Jabłonowska-Lietz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: The fat mass & obesity-associated (FTO) gene is linked to an increased risk of obesity. However, the relation between rs9939609 and eating behaviors or energy expenditure is not fully elucidated. The aim of this study was to investigate the relationship between the rs9939609 polymorphism of the FTO gene and the postprandial satiety, sweets intake, physical activity and depressive symptoms in patients with obesity. Methods: The study group consisted of 585 subjects with a BMI of 42.97.0 kg/m². The rs9939609 polymorphism of the FTO gene was examined using real time – PCR method. The severity of depressive symptoms was assessed with the Beck Depression Inventory (BDI-II). Information was obtained about demographics, eating habits and lifestyle. Results: More than half (63.5%) of the patients reported consumption of sweets between main meals and 30% declared high and very high postprandial satiety and the frequency of TA/AA carriers in rs9939609 (FTO) compared with TT carriers was similar. Significantly lower BDI-II scores were found in subjects with higher level of physical activity and it was seen amongst patients with the AA and AT genotypes of the FTO rs9939609 polymorphism. Conclusion: Obesity is a highly heritable trait, but eating habits also appear as major factors affecting obesity development. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=FTO%20polymorphism" title="FTO polymorphism">FTO polymorphism</a>, <a href="https://publications.waset.org/abstracts/search?q=physical%20activity" title=" physical activity"> physical activity</a>, <a href="https://publications.waset.org/abstracts/search?q=obesity" title=" obesity"> obesity</a>, <a href="https://publications.waset.org/abstracts/search?q=depression" title=" depression"> depression</a>, <a href="https://publications.waset.org/abstracts/search?q=postprandial%20satiety" title=" postprandial satiety"> postprandial satiety</a>, <a href="https://publications.waset.org/abstracts/search?q=sugary%20foods" title=" sugary foods"> sugary foods</a>, <a href="https://publications.waset.org/abstracts/search?q=sweets" title=" sweets"> sweets</a> </p> <a href="https://publications.waset.org/abstracts/153873/postprandial-satiety-sweets-intake-physical-activity-and-depressive-symptoms-in-relation-to-rs9939609-polymorphism-of-the-fto-gene" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/153873.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">128</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">226</span> Xeroderma Pigmentosum Group G: Gene Polymorphism and Risk of Breast Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Malik%20SS">Malik SS</a>, <a href="https://publications.waset.org/abstracts/search?q=Masood%20N"> Masood N</a>, <a href="https://publications.waset.org/abstracts/search?q=Mubarik%20S"> Mubarik S</a>, <a href="https://publications.waset.org/abstracts/search?q=Khadim%20TM"> Khadim TM</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Xeroderma pigmentosum group G (XPG) gene plays a crucial role in the correction of UV-induced DNA damage through nucleotide excision repair pathway. Single nucleotide polymorphisms in XPG gene have been reported to be associated with different cancers. Current case-control study was designed to evaluate the relationship between one of the most frequently found XPG (rs1047768 T>C) polymorphism and breast cancer risk. Methodology: A total of 200 individuals were screened for this polymorphism including 100 pathologically confirmed breast cancer cases and age-matched 100 controls. Genotyping was carried out using Tetra amplification-refractory mutation system (ARMS) PCR and results were confirmed by gel electrophoresis. Results: Conditional logistic regression analysis showed significant association between TC genotype (OR: 8.9, CI: 2.0 – 38.7) and increased breast cancer risk. Although homozygous CC genotype was more frequent in patients as compared to controls, but it was statistically non-significant (OR: 3.9, CI: 0.4 – 35.7). Conclusion: In conclusion, XPG (rs1047768 T>C) polymorphism may contribute towards increased risk of breast cancer but other polymorphisms may also be evaluated to elucidate their role in breast cancer. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=XPG" title="XPG">XPG</a>, <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title=" breast cancer"> breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=NER" title=" NER"> NER</a>, <a href="https://publications.waset.org/abstracts/search?q=ARMS-PCR" title=" ARMS-PCR"> ARMS-PCR</a> </p> <a href="https://publications.waset.org/abstracts/89352/xeroderma-pigmentosum-group-g-gene-polymorphism-and-risk-of-breast-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/89352.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">188</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">225</span> A C/T Polymorphism at the 5’ Untranslated Region of CD40 Gene in Patients Associated with Graves’ Disease in Kumaon Region</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sanjeev%20Kumar%20Shukla">Sanjeev Kumar Shukla</a>, <a href="https://publications.waset.org/abstracts/search?q=Govind%20Singh"> Govind Singh</a>, <a href="https://publications.waset.org/abstracts/search?q=Prabhat%20Pant%20%20%20%20%20%20Shahzad%20Ahmad"> Prabhat Pant Shahzad Ahmad</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Graves’ disease is an autoimmune disorder with a genetic predisposition, and CD40 plays a pathogenic role in various autoimmune diseases. A single nucleotide polymorphism at position –1 of the Kozak sequence of the 5 untranslated regions of the CD40 gene of exon 1 has been reported to be associated with the development of Graves’ Disease. Objective: The aim of the present study was to investigate whether CD40 gene polymorphism confers susceptibility to Graves’ disease in the Kumaon region. CD40 gene polymorphisms were studied in Graves’ Disease patients (n=50) and healthy control subjects without anti-thyroid autoantibodies or a family history of autoimmune disorders (n=50). Material and Method: CD40 gene polymorphisms were studied in fifty Graves’ Disease patients and fifty healthy control subjects. All samples were collected from STG Hospital, Haldwani, Nainital. A C/T polymorphism at position –1 of the CD40 gene was measured using the polymerase chain reaction-restriction fragment length polymorphism. Results: There was no significant difference in allele or genotype frequency of the CD40 SNP between Graves’ Disease and control subjects. There was a significant decrease in the TT genotype frequency in the Graves’ Disease patients who developed Graves’ Disease after 40 years old than those under 40 years of age. These data suggest that the SNP of the CD40 gene is associated with susceptibility to the later onset of Graves’ Disease. Conclusion: The CD40 gene was a different susceptibility gene for Graves’ Disease within certain families because it was both linked and associated with Graves’ Disease. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=autoimmune%20%20%20diseases" title="autoimmune diseases">autoimmune diseases</a>, <a href="https://publications.waset.org/abstracts/search?q=pathogenesis" title=" pathogenesis"> pathogenesis</a>, <a href="https://publications.waset.org/abstracts/search?q=diagnosis" title=" diagnosis"> diagnosis</a>, <a href="https://publications.waset.org/abstracts/search?q=therapy" title=" therapy"> therapy</a> </p> <a href="https://publications.waset.org/abstracts/185356/a-ct-polymorphism-at-the-5-untranslated-region-of-cd40-gene-in-patients-associated-with-graves-disease-in-kumaon-region" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/185356.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">51</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">224</span> Evaluation of Genetic Diversity in Iranian Native Silkworm Bombyx mori Using RAPD (Random Amplification of Polymorphic DNA) Molecular Marker</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rouhollah%20Radjabi">Rouhollah Radjabi</a>, <a href="https://publications.waset.org/abstracts/search?q=Mojtaba%20Zarei"> Mojtaba Zarei</a>, <a href="https://publications.waset.org/abstracts/search?q=Elham%20Sanatgar"> Elham Sanatgar</a>, <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Shouhani"> Hossein Shouhani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> RAPD molecular markers in order to discrimination of the Iranian native Bombyx mori silkworm breeds were used. DNA extraction using phenol - chloroform was and the qualitative and quantitative measurements of extracted DNA and its dilution, the obtained bands on agarose gel 1.5 percent were marked and analyzed. Results showed that the bands are observed between 250-2500 bp and most bands have been observed as Gilani-orange, the lowest bands observed are Khorasani-lemon. Primer 3 with 100% polymorphism with the highest polymorphism and primer 2 with 61.5 polymorphism had the lowest percentage of polymorphism. Cluster analysis of races and placed them in three main groups, races Gilani - orange, Baghdad and Khorasani -pink if the first group, camel's thorn, Herati - yellow race was alone in the second group and Khorasani – lemon was alone in the third group. The greatest similarity between the races, between Khorasani- pink and Baghdad (0.64). RAPD markers have been determined different silkworm races based on various morphological or economic characteristics except geographic origin. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=silkworm" title="silkworm">silkworm</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20marker" title=" molecular marker"> molecular marker</a>, <a href="https://publications.waset.org/abstracts/search?q=RAPD" title=" RAPD"> RAPD</a>, <a href="https://publications.waset.org/abstracts/search?q=Iran" title=" Iran"> Iran</a> </p> <a href="https://publications.waset.org/abstracts/37569/evaluation-of-genetic-diversity-in-iranian-native-silkworm-bombyx-mori-using-rapd-random-amplification-of-polymorphic-dna-molecular-marker" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37569.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 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