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class="vector-toc-list"> </ul> </li> <li id="toc-Izoprenoidinių_molekulių_kondensacija_ir_skvaleno_sintezė" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Izoprenoidinių_molekulių_kondensacija_ir_skvaleno_sintezė"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.3</span> <span>Izoprenoidinių molekulių kondensacija ir skvaleno sintezė</span> </div> </a> <ul id="toc-Izoprenoidinių_molekulių_kondensacija_ir_skvaleno_sintezė-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Skvaleno_ciklizacija_ir_lanosterolio_susidarymas" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Skvaleno_ciklizacija_ir_lanosterolio_susidarymas"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.4</span> <span>Skvaleno ciklizacija ir lanosterolio susidarymas</span> </div> </a> <ul id="toc-Skvaleno_ciklizacija_ir_lanosterolio_susidarymas-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Lanosterolio_virtimas_cholesteroliu" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Lanosterolio_virtimas_cholesteroliu"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.5</span> <span>Lanosterolio virtimas cholesteroliu</span> </div> </a> <ul id="toc-Lanosterolio_virtimas_cholesteroliu-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Literatūra" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Literatūra"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Literatūra</span> </div> </a> <ul id="toc-Literatūra-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Turinys" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Cholesterolis</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 100 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-100" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">100 kalbų</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-af mw-list-item"><a href="https://af.wikipedia.org/wiki/Cholesterol" title="Cholesterol – afrikanų" lang="af" hreflang="af" data-title="Cholesterol" data-language-autonym="Afrikaans" data-language-local-name="afrikanų" class="interlanguage-link-target"><span>Afrikaans</span></a></li><li class="interlanguage-link interwiki-am mw-list-item"><a href="https://am.wikipedia.org/wiki/%E1%8A%AE%E1%88%8C%E1%88%B5%E1%89%B5%E1%88%AE%E1%88%8D" title="ኮሌስትሮል – amharų" lang="am" hreflang="am" data-title="ኮሌስትሮል" data-language-autonym="አማርኛ" data-language-local-name="amharų" class="interlanguage-link-target"><span>አማርኛ</span></a></li><li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%83%D9%88%D9%84%D8%B3%D8%AA%D8%B1%D9%88%D9%84" title="كولسترول – arabų" lang="ar" hreflang="ar" data-title="كولسترول" data-language-autonym="العربية" data-language-local-name="arabų" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-as mw-list-item"><a href="https://as.wikipedia.org/wiki/%E0%A6%95%E0%A6%B2%E0%A7%87%E0%A6%B7%E0%A7%8D%E0%A6%9F%E0%A7%87%E0%A7%B0%E0%A6%B2" title="কলেষ্টেৰল – asamų" lang="as" hreflang="as" data-title="কলেষ্টেৰল" data-language-autonym="অসমীয়া" data-language-local-name="asamų" class="interlanguage-link-target"><span>অসমীয়া</span></a></li><li class="interlanguage-link interwiki-ast mw-list-item"><a href="https://ast.wikipedia.org/wiki/Colesterol" title="Colesterol – asturianų" lang="ast" hreflang="ast" data-title="Colesterol" data-language-autonym="Asturianu" data-language-local-name="asturianų" class="interlanguage-link-target"><span>Asturianu</span></a></li><li class="interlanguage-link interwiki-az mw-list-item"><a href="https://az.wikipedia.org/wiki/Xolesterin" title="Xolesterin – azerbaidžaniečių" lang="az" hreflang="az" data-title="Xolesterin" data-language-autonym="Azərbaycanca" data-language-local-name="azerbaidžaniečių" class="interlanguage-link-target"><span>Azərbaycanca</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%DA%A9%D9%84%D8%B3%D8%AA%D8%B1%D9%88%D9%84" title="کلسترول – South Azerbaijani" lang="azb" hreflang="azb" data-title="کلسترول" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-bcl mw-list-item"><a href="https://bcl.wikipedia.org/wiki/Kolesterol" title="Kolesterol – Central Bikol" lang="bcl" hreflang="bcl" data-title="Kolesterol" data-language-autonym="Bikol Central" data-language-local-name="Central Bikol" class="interlanguage-link-target"><span>Bikol Central</span></a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/%D0%A5%D0%B0%D0%BB%D0%B5%D1%81%D1%82%D1%8D%D1%80%D1%8B%D0%BD" title="Халестэрын – baltarusių" lang="be" hreflang="be" data-title="Халестэрын" data-language-autonym="Беларуская" data-language-local-name="baltarusių" class="interlanguage-link-target"><span>Беларуская</span></a></li><li class="interlanguage-link interwiki-be-x-old mw-list-item"><a href="https://be-tarask.wikipedia.org/wiki/%D0%A5%D0%B0%D0%BB%D0%B5%D1%81%D1%82%D1%8D%D1%80%D1%8B%D0%BD" title="Халестэрын – Belarusian (Taraškievica orthography)" lang="be-tarask" hreflang="be-tarask" data-title="Халестэрын" data-language-autonym="Беларуская (тарашкевіца)" data-language-local-name="Belarusian (Taraškievica orthography)" class="interlanguage-link-target"><span>Беларуская (тарашкевіца)</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%A5%D0%BE%D0%BB%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%BE%D0%BB" title="Холестерол – bulgarų" lang="bg" hreflang="bg" data-title="Холестерол" data-language-autonym="Български" data-language-local-name="bulgarų" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%95%E0%A7%8B%E0%A6%B2%E0%A7%87%E0%A6%B8%E0%A7%8D%E0%A6%9F%E0%A7%87%E0%A6%B0%E0%A6%B2" title="কোলেস্টেরল – bengalų" lang="bn" hreflang="bn" data-title="কোলেস্টেরল" data-language-autonym="বাংলা" data-language-local-name="bengalų" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-br mw-list-item"><a href="https://br.wikipedia.org/wiki/Kolesterol" title="Kolesterol – bretonų" lang="br" hreflang="br" data-title="Kolesterol" data-language-autonym="Brezhoneg" data-language-local-name="bretonų" class="interlanguage-link-target"><span>Brezhoneg</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Holesterol" title="Holesterol – bosnių" lang="bs" hreflang="bs" data-title="Holesterol" data-language-autonym="Bosanski" data-language-local-name="bosnių" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Colesterol" title="Colesterol – katalonų" lang="ca" hreflang="ca" data-title="Colesterol" data-language-autonym="Català" data-language-local-name="katalonų" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-ckb mw-list-item"><a href="https://ckb.wikipedia.org/wiki/%DA%A9%DB%86%D9%84%DB%8C%D8%B3%D8%AA%DA%95%DB%86%DA%B5" title="کۆلیستڕۆڵ – soranių kurdų" lang="ckb" hreflang="ckb" data-title="کۆلیستڕۆڵ" data-language-autonym="کوردی" data-language-local-name="soranių kurdų" class="interlanguage-link-target"><span>کوردی</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Cholesterol" title="Cholesterol – čekų" lang="cs" hreflang="cs" data-title="Cholesterol" data-language-autonym="Čeština" data-language-local-name="čekų" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-cv mw-list-item"><a href="https://cv.wikipedia.org/wiki/%D0%A5%D0%BE%D0%BB%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%B8%D0%BD" title="Холестерин – čiuvašų" lang="cv" hreflang="cv" data-title="Холестерин" data-language-autonym="Чӑвашла" data-language-local-name="čiuvašų" class="interlanguage-link-target"><span>Чӑвашла</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Cholesterol" title="Cholesterol – valų" lang="cy" hreflang="cy" data-title="Cholesterol" data-language-autonym="Cymraeg" data-language-local-name="valų" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Kolesterol" title="Kolesterol – danų" lang="da" hreflang="da" data-title="Kolesterol" data-language-autonym="Dansk" data-language-local-name="danų" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Cholesterin" title="Cholesterin – vokiečių" lang="de" hreflang="de" data-title="Cholesterin" data-language-autonym="Deutsch" data-language-local-name="vokiečių" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-dv mw-list-item"><a href="https://dv.wikipedia.org/wiki/%DE%86%DE%AE%DE%8D%DE%AC%DE%90%DE%B0%DE%93%DE%B0%DE%83%DE%AF%DE%8D%DE%B0" title="ކޮލެސްޓްރޯލް – divehų" lang="dv" hreflang="dv" data-title="ކޮލެސްޓްރޯލް" data-language-autonym="ދިވެހިބަސް" data-language-local-name="divehų" class="interlanguage-link-target"><span>ދިވެހިބަސް</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%A7%CE%BF%CE%BB%CE%B7%CF%83%CF%84%CE%B5%CF%81%CF%8C%CE%BB%CE%B7" title="Χοληστερόλη – graikų" lang="el" hreflang="el" data-title="Χοληστερόλη" data-language-autonym="Ελληνικά" data-language-local-name="graikų" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Cholesterol" title="Cholesterol – anglų" lang="en" hreflang="en" data-title="Cholesterol" data-language-autonym="English" data-language-local-name="anglų" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Kolesterolo" title="Kolesterolo – esperanto" lang="eo" hreflang="eo" data-title="Kolesterolo" data-language-autonym="Esperanto" data-language-local-name="esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Colesterol" title="Colesterol – ispanų" lang="es" hreflang="es" data-title="Colesterol" data-language-autonym="Español" data-language-local-name="ispanų" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Kolesterool" title="Kolesterool – estų" lang="et" hreflang="et" data-title="Kolesterool" data-language-autonym="Eesti" data-language-local-name="estų" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Kolesterol" title="Kolesterol – baskų" lang="eu" hreflang="eu" data-title="Kolesterol" data-language-autonym="Euskara" data-language-local-name="baskų" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%A9%D9%84%D8%B3%D8%AA%D8%B1%D9%88%D9%84" title="کلسترول – persų" lang="fa" hreflang="fa" data-title="کلسترول" data-language-autonym="فارسی" data-language-local-name="persų" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Kolesteroli" title="Kolesteroli – suomių" lang="fi" hreflang="fi" data-title="Kolesteroli" data-language-autonym="Suomi" data-language-local-name="suomių" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Cholest%C3%A9rol" title="Cholestérol – prancūzų" lang="fr" hreflang="fr" data-title="Cholestérol" data-language-autonym="Français" data-language-local-name="prancūzų" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ga mw-list-item"><a href="https://ga.wikipedia.org/wiki/Colaist%C3%A9ar%C3%B3l" title="Colaistéaról – airių" lang="ga" hreflang="ga" data-title="Colaistéaról" data-language-autonym="Gaeilge" data-language-local-name="airių" class="interlanguage-link-target"><span>Gaeilge</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Colesterol" title="Colesterol – galisų" lang="gl" hreflang="gl" data-title="Colesterol" data-language-autonym="Galego" data-language-local-name="galisų" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%9B%D7%95%D7%9C%D7%A1%D7%98%D7%A8%D7%95%D7%9C" title="כולסטרול – hebrajų" lang="he" hreflang="he" data-title="כולסטרול" data-language-autonym="עברית" data-language-local-name="hebrajų" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hi mw-list-item"><a href="https://hi.wikipedia.org/wiki/%E0%A4%95%E0%A5%8B%E0%A4%B2%E0%A5%87%E0%A4%B8%E0%A5%8D%E0%A4%9F%E0%A5%87%E0%A4%B0%E0%A5%89%E0%A4%B2" title="कोलेस्टेरॉल – hindi" lang="hi" hreflang="hi" data-title="कोलेस्टेरॉल" data-language-autonym="हिन्दी" data-language-local-name="hindi" class="interlanguage-link-target"><span>हिन्दी</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Kolesterol" title="Kolesterol – kroatų" lang="hr" hreflang="hr" data-title="Kolesterol" data-language-autonym="Hrvatski" data-language-local-name="kroatų" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Koleszterin" title="Koleszterin – vengrų" lang="hu" hreflang="hu" data-title="Koleszterin" data-language-autonym="Magyar" data-language-local-name="vengrų" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%BD%D5%B8%D5%AC%D5%A5%D5%BD%D5%A9%D5%A5%D6%80%D5%AB%D5%B6" title="Խոլեսթերին – armėnų" lang="hy" hreflang="hy" data-title="Խոլեսթերին" data-language-autonym="Հայերեն" data-language-local-name="armėnų" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-ia mw-list-item"><a href="https://ia.wikipedia.org/wiki/Cholesterol" title="Cholesterol – tarpinė" lang="ia" hreflang="ia" data-title="Cholesterol" data-language-autonym="Interlingua" data-language-local-name="tarpinė" class="interlanguage-link-target"><span>Interlingua</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Kolesterol" title="Kolesterol – indoneziečių" lang="id" hreflang="id" data-title="Kolesterol" data-language-autonym="Bahasa Indonesia" data-language-local-name="indoneziečių" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-is mw-list-item"><a href="https://is.wikipedia.org/wiki/K%C3%B3lester%C3%B3l" title="Kólesteról – islandų" lang="is" hreflang="is" data-title="Kólesteról" data-language-autonym="Íslenska" data-language-local-name="islandų" class="interlanguage-link-target"><span>Íslenska</span></a></li><li class="interlanguage-link interwiki-it badge-Q17437798 badge-goodarticle mw-list-item" title="vertingas straipsnis"><a href="https://it.wikipedia.org/wiki/Colesterolo" title="Colesterolo – italų" lang="it" hreflang="it" data-title="Colesterolo" data-language-autonym="Italiano" data-language-local-name="italų" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja badge-Q17437796 badge-featuredarticle mw-list-item" title="pavyzdinis straipsnis"><a href="https://ja.wikipedia.org/wiki/%E3%82%B3%E3%83%AC%E3%82%B9%E3%83%86%E3%83%AD%E3%83%BC%E3%83%AB" title="コレステロール – japonų" lang="ja" hreflang="ja" data-title="コレステロール" data-language-autonym="日本語" data-language-local-name="japonų" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-jv mw-list-item"><a href="https://jv.wikipedia.org/wiki/Kolesterol" title="Kolesterol – javiečių" lang="jv" hreflang="jv" data-title="Kolesterol" data-language-autonym="Jawa" data-language-local-name="javiečių" class="interlanguage-link-target"><span>Jawa</span></a></li><li class="interlanguage-link interwiki-ka mw-list-item"><a href="https://ka.wikipedia.org/wiki/%E1%83%A5%E1%83%9D%E1%83%9A%E1%83%94%E1%83%A1%E1%83%A2%E1%83%94%E1%83%A0%E1%83%98%E1%83%9C%E1%83%98" title="ქოლესტერინი – gruzinų" lang="ka" hreflang="ka" data-title="ქოლესტერინი" data-language-autonym="ქართული" data-language-local-name="gruzinų" class="interlanguage-link-target"><span>ქართული</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%A5%D0%BE%D0%BB%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%B8%D0%BD" title="Холестерин – kazachų" lang="kk" hreflang="kk" data-title="Холестерин" data-language-autonym="Қазақша" data-language-local-name="kazachų" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-kn mw-list-item"><a href="https://kn.wikipedia.org/wiki/%E0%B2%95%E0%B3%8A%E0%B2%B2%E0%B3%86%E0%B2%B8%E0%B3%8D%E0%B2%9F%E0%B2%B0%E0%B2%BE%E0%B2%B2%E0%B3%8D%E2%80%8C" title="ಕೊಲೆಸ್ಟರಾಲ್‌ – kanadų" lang="kn" hreflang="kn" data-title="ಕೊಲೆಸ್ಟರಾಲ್‌" data-language-autonym="ಕನ್ನಡ" data-language-local-name="kanadų" class="interlanguage-link-target"><span>ಕನ್ನಡ</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%BD%9C%EB%A0%88%EC%8A%A4%ED%85%8C%EB%A1%A4" title="콜레스테롤 – korėjiečių" lang="ko" hreflang="ko" data-title="콜레스테롤" data-language-autonym="한국어" data-language-local-name="korėjiečių" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ks mw-list-item"><a href="https://ks.wikipedia.org/wiki/%DA%A9%D9%88%D9%84%DB%8C%D8%B3%D9%B9%D8%B1%D8%A7%D9%84" title="کولیسٹرال – kašmyrų" lang="ks" hreflang="ks" data-title="کولیسٹرال" data-language-autonym="कॉशुर / کٲشُر" data-language-local-name="kašmyrų" class="interlanguage-link-target"><span>कॉशुर / کٲشُر</span></a></li><li class="interlanguage-link interwiki-ky mw-list-item"><a href="https://ky.wikipedia.org/wiki/%D0%A5%D0%BE%D0%BB%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%B8%D0%BD" title="Холестерин – kirgizų" lang="ky" hreflang="ky" data-title="Холестерин" data-language-autonym="Кыргызча" data-language-local-name="kirgizų" class="interlanguage-link-target"><span>Кыргызча</span></a></li><li class="interlanguage-link interwiki-la mw-list-item"><a href="https://la.wikipedia.org/wiki/Cholesterolum" title="Cholesterolum – lotynų" lang="la" hreflang="la" data-title="Cholesterolum" data-language-autonym="Latina" data-language-local-name="lotynų" class="interlanguage-link-target"><span>Latina</span></a></li><li class="interlanguage-link interwiki-lo mw-list-item"><a href="https://lo.wikipedia.org/wiki/%E0%BB%82%E0%BA%81%E0%BB%81%E0%BA%A5%E0%BA%AA%E0%BA%B0%E0%BB%80%E0%BA%95%E0%BB%82%E0%BA%A5%E0%BA%99" title="ໂກແລສະເຕໂລນ – laosiečių" lang="lo" hreflang="lo" data-title="ໂກແລສະເຕໂລນ" data-language-autonym="ລາວ" data-language-local-name="laosiečių" class="interlanguage-link-target"><span>ລາວ</span></a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Holester%C4%ABns" title="Holesterīns – latvių" lang="lv" hreflang="lv" data-title="Holesterīns" data-language-autonym="Latviešu" data-language-local-name="latvių" class="interlanguage-link-target"><span>Latviešu</span></a></li><li class="interlanguage-link interwiki-mg mw-list-item"><a href="https://mg.wikipedia.org/wiki/K%C3%B4lesterola" title="Kôlesterola – malagasų" lang="mg" hreflang="mg" data-title="Kôlesterola" data-language-autonym="Malagasy" data-language-local-name="malagasų" class="interlanguage-link-target"><span>Malagasy</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%A5%D0%BE%D0%BB%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%BE%D0%BB" title="Холестерол – makedonų" lang="mk" hreflang="mk" data-title="Холестерол" data-language-autonym="Македонски" data-language-local-name="makedonų" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%95%E0%B5%8A%E0%B4%B3%E0%B4%B8%E0%B5%8D%E0%B4%9F%E0%B5%8D%E0%B4%B0%E0%B5%8B%E0%B5%BE" title="കൊളസ്ട്രോൾ – malajalių" lang="ml" hreflang="ml" data-title="കൊളസ്ട്രോൾ" data-language-autonym="മലയാളം" data-language-local-name="malajalių" class="interlanguage-link-target"><span>മലയാളം</span></a></li><li class="interlanguage-link interwiki-mr mw-list-item"><a href="https://mr.wikipedia.org/wiki/%E0%A4%95%E0%A5%89%E0%A4%B2%E0%A5%87%E0%A4%B8%E0%A5%8D%E0%A4%9F%E0%A5%87%E0%A4%B0%E0%A5%89%E0%A4%B2" title="कॉलेस्टेरॉल – maratų" lang="mr" hreflang="mr" data-title="कॉलेस्टेरॉल" data-language-autonym="मराठी" data-language-local-name="maratų" class="interlanguage-link-target"><span>मराठी</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Kolesterol" title="Kolesterol – malajiečių" lang="ms" hreflang="ms" data-title="Kolesterol" data-language-autonym="Bahasa Melayu" data-language-local-name="malajiečių" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-my mw-list-item"><a href="https://my.wikipedia.org/wiki/%E1%80%80%E1%80%AD%E1%80%AF%E1%80%9C%E1%80%80%E1%80%BA%E1%80%85%E1%80%91%E1%80%9B%E1%80%B1%E1%80%AC" title="ကိုလက်စထရော – birmiečių" lang="my" hreflang="my" data-title="ကိုလက်စထရော" data-language-autonym="မြန်မာဘာသာ" data-language-local-name="birmiečių" class="interlanguage-link-target"><span>မြန်မာဘာသာ</span></a></li><li class="interlanguage-link interwiki-ne mw-list-item"><a href="https://ne.wikipedia.org/wiki/%E0%A4%95%E0%A5%8B%E0%A4%B2%E0%A5%87%E0%A4%B8%E0%A5%8D%E0%A4%9F%E0%A5%87%E0%A4%B0%E0%A5%8B%E0%A4%B2" title="कोलेस्टेरोल – nepaliečių" lang="ne" hreflang="ne" data-title="कोलेस्टेरोल" data-language-autonym="नेपाली" data-language-local-name="nepaliečių" class="interlanguage-link-target"><span>नेपाली</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Cholesterol" title="Cholesterol – olandų" lang="nl" hreflang="nl" data-title="Cholesterol" data-language-autonym="Nederlands" data-language-local-name="olandų" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-nn mw-list-item"><a href="https://nn.wikipedia.org/wiki/Kolesterol" title="Kolesterol – naujoji norvegų" lang="nn" hreflang="nn" data-title="Kolesterol" data-language-autonym="Norsk nynorsk" data-language-local-name="naujoji norvegų" class="interlanguage-link-target"><span>Norsk nynorsk</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Kolesterol" title="Kolesterol – norvegų bukmolas" lang="nb" hreflang="nb" data-title="Kolesterol" data-language-autonym="Norsk bokmål" data-language-local-name="norvegų bukmolas" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-oc mw-list-item"><a href="https://oc.wikipedia.org/wiki/Colester%C3%B2l" title="Colesteròl – očitarų" lang="oc" hreflang="oc" data-title="Colesteròl" data-language-autonym="Occitan" data-language-local-name="očitarų" class="interlanguage-link-target"><span>Occitan</span></a></li><li class="interlanguage-link interwiki-om mw-list-item"><a href="https://om.wikipedia.org/wiki/Kolestroolii" title="Kolestroolii – oromų" lang="om" hreflang="om" data-title="Kolestroolii" data-language-autonym="Oromoo" data-language-local-name="oromų" class="interlanguage-link-target"><span>Oromoo</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%95%E0%AD%8B%E0%AC%B2%E0%AD%87%E0%AC%B7%E0%AD%8D%E0%AC%9F%E0%AD%87%E0%AC%B0%E0%AD%8B%E0%AC%B2" title="କୋଲେଷ୍ଟେରୋଲ – odijų" lang="or" hreflang="or" data-title="କୋଲେଷ୍ଟେରୋଲ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="odijų" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Cholesterol" title="Cholesterol – lenkų" lang="pl" hreflang="pl" data-title="Cholesterol" data-language-autonym="Polski" data-language-local-name="lenkų" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Colesterol" title="Colesterol – portugalų" lang="pt" hreflang="pt" data-title="Colesterol" data-language-autonym="Português" data-language-local-name="portugalų" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-rn mw-list-item"><a href="https://rn.wikipedia.org/wiki/Kolesterole" title="Kolesterole – rundi" lang="rn" hreflang="rn" data-title="Kolesterole" data-language-autonym="Ikirundi" data-language-local-name="rundi" class="interlanguage-link-target"><span>Ikirundi</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Colesterol" title="Colesterol – rumunų" lang="ro" hreflang="ro" data-title="Colesterol" data-language-autonym="Română" data-language-local-name="rumunų" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A5%D0%BE%D0%BB%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%B8%D0%BD" title="Холестерин – rusų" lang="ru" hreflang="ru" data-title="Холестерин" data-language-autonym="Русский" data-language-local-name="rusų" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-rw mw-list-item"><a href="https://rw.wikipedia.org/wiki/Cholest%C3%A9rol" title="Cholestérol – kinjaruandų" lang="rw" hreflang="rw" data-title="Cholestérol" data-language-autonym="Ikinyarwanda" data-language-local-name="kinjaruandų" class="interlanguage-link-target"><span>Ikinyarwanda</span></a></li><li class="interlanguage-link interwiki-sah mw-list-item"><a href="https://sah.wikipedia.org/wiki/%D0%A5%D0%BE%D0%BB%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%B8%D0%BD" title="Холестерин – jakutų" lang="sah" hreflang="sah" data-title="Холестерин" data-language-autonym="Саха тыла" data-language-local-name="jakutų" class="interlanguage-link-target"><span>Саха тыла</span></a></li><li class="interlanguage-link interwiki-sd mw-list-item"><a href="https://sd.wikipedia.org/wiki/%DA%AA%D9%88%D9%84%D9%8A%D8%B3%D9%BD%D8%B1%D9%88%D9%84" title="ڪوليسٽرول – sindų" lang="sd" hreflang="sd" data-title="ڪوليسٽرول" data-language-autonym="سنڌي" data-language-local-name="sindų" class="interlanguage-link-target"><span>سنڌي</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Holesterol" title="Holesterol – serbų-kroatų" lang="sh" hreflang="sh" data-title="Holesterol" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbų-kroatų" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-si mw-list-item"><a href="https://si.wikipedia.org/wiki/%E0%B6%9A%E0%B7%9C%E0%B6%BD%E0%B7%99%E0%B7%83%E0%B7%8A%E0%B6%A7%E0%B6%BB%E0%B7%9D%E0%B6%BD%E0%B7%8A" title="කොලෙස්ටරෝල් – sinhalų" lang="si" hreflang="si" data-title="කොලෙස්ටරෝල්" data-language-autonym="සිංහල" data-language-local-name="sinhalų" class="interlanguage-link-target"><span>සිංහල</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Cholesterol" title="Cholesterol – Simple English" lang="en-simple" hreflang="en-simple" data-title="Cholesterol" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Cholesterol" title="Cholesterol – slovakų" lang="sk" hreflang="sk" data-title="Cholesterol" data-language-autonym="Slovenčina" data-language-local-name="slovakų" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Holesterol" title="Holesterol – slovėnų" lang="sl" hreflang="sl" data-title="Holesterol" data-language-autonym="Slovenščina" data-language-local-name="slovėnų" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sq mw-list-item"><a href="https://sq.wikipedia.org/wiki/Kolesteroli" title="Kolesteroli – albanų" lang="sq" hreflang="sq" data-title="Kolesteroli" data-language-autonym="Shqip" data-language-local-name="albanų" class="interlanguage-link-target"><span>Shqip</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%A5%D0%BE%D0%BB%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%BE%D0%BB" title="Холестерол – serbų" lang="sr" hreflang="sr" data-title="Холестерол" data-language-autonym="Српски / srpski" data-language-local-name="serbų" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-su mw-list-item"><a href="https://su.wikipedia.org/wiki/Kolesterol" title="Kolesterol – sundų" lang="su" hreflang="su" data-title="Kolesterol" data-language-autonym="Sunda" data-language-local-name="sundų" class="interlanguage-link-target"><span>Sunda</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Kolesterol" title="Kolesterol – švedų" lang="sv" hreflang="sv" data-title="Kolesterol" data-language-autonym="Svenska" data-language-local-name="švedų" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-sw mw-list-item"><a href="https://sw.wikipedia.org/wiki/Kolesteroli" title="Kolesteroli – suahilių" lang="sw" hreflang="sw" data-title="Kolesteroli" data-language-autonym="Kiswahili" data-language-local-name="suahilių" class="interlanguage-link-target"><span>Kiswahili</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%95%E0%AF%8A%E0%AE%B2%E0%AE%B8%E0%AF%8D%E0%AE%9F%E0%AE%BF%E0%AE%B0%E0%AE%BE%E0%AE%B2%E0%AF%8D" title="கொலஸ்டிரால் – tamilų" lang="ta" hreflang="ta" data-title="கொலஸ்டிரால்" data-language-autonym="தமிழ்" data-language-local-name="tamilų" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-te badge-Q70893996 mw-list-item" title=""><a href="https://te.wikipedia.org/wiki/%E0%B0%95%E0%B1%8A%E0%B0%B2%E0%B1%86%E0%B0%B8%E0%B1%8D%E0%B0%9F%E0%B1%8D%E0%B0%B0%E0%B0%BE%E0%B0%B2%E0%B1%8D" title="కొలెస్ట్రాల్ – telugų" lang="te" hreflang="te" data-title="కొలెస్ట్రాల్" data-language-autonym="తెలుగు" data-language-local-name="telugų" class="interlanguage-link-target"><span>తెలుగు</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%84%E0%B8%AD%E0%B9%80%E0%B8%A5%E0%B8%AA%E0%B9%80%E0%B8%95%E0%B8%AD%E0%B8%A3%E0%B8%AD%E0%B8%A5" title="คอเลสเตอรอล – tajų" lang="th" hreflang="th" data-title="คอเลสเตอรอล" data-language-autonym="ไทย" data-language-local-name="tajų" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tl mw-list-item"><a href="https://tl.wikipedia.org/wiki/Kolesterol" title="Kolesterol – tagalogų" lang="tl" hreflang="tl" data-title="Kolesterol" data-language-autonym="Tagalog" data-language-local-name="tagalogų" class="interlanguage-link-target"><span>Tagalog</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Kolesterol" title="Kolesterol – turkų" lang="tr" hreflang="tr" data-title="Kolesterol" data-language-autonym="Türkçe" data-language-local-name="turkų" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/%D0%A5%D0%BE%D0%BB%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%B8%D0%BD" title="Холестерин – totorių" lang="tt" hreflang="tt" data-title="Холестерин" data-language-autonym="Татарча / tatarça" data-language-local-name="totorių" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A5%D0%BE%D0%BB%D0%B5%D1%81%D1%82%D0%B5%D1%80%D0%BE%D0%BB" title="Холестерол – ukrainiečių" lang="uk" hreflang="uk" data-title="Холестерол" data-language-autonym="Українська" data-language-local-name="ukrainiečių" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-ur mw-list-item"><a href="https://ur.wikipedia.org/wiki/%DA%A9%D9%88%D9%84%DB%8C%D8%B3%D9%B9%D8%B1%D8%A7%D9%84" title="کولیسٹرال – urdų" lang="ur" hreflang="ur" data-title="کولیسٹرال" data-language-autonym="اردو" data-language-local-name="urdų" class="interlanguage-link-target"><span>اردو</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Xolesterin" title="Xolesterin – uzbekų" lang="uz" hreflang="uz" data-title="Xolesterin" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="uzbekų" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Cholesterol" title="Cholesterol – vietnamiečių" lang="vi" hreflang="vi" data-title="Cholesterol" data-language-autonym="Tiếng Việt" data-language-local-name="vietnamiečių" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-wa mw-list-item"><a href="https://wa.wikipedia.org/wiki/Colesterol" title="Colesterol – valonų" lang="wa" hreflang="wa" data-title="Colesterol" data-language-autonym="Walon" data-language-local-name="valonų" class="interlanguage-link-target"><span>Walon</span></a></li><li class="interlanguage-link interwiki-war mw-list-item"><a href="https://war.wikipedia.org/wiki/Kolesterol" title="Kolesterol – varai" lang="war" hreflang="war" data-title="Kolesterol" data-language-autonym="Winaray" data-language-local-name="varai" class="interlanguage-link-target"><span>Winaray</span></a></li><li class="interlanguage-link interwiki-wuu mw-list-item"><a href="https://wuu.wikipedia.org/wiki/%E8%83%86%E5%9B%BA%E9%86%87" title="胆固醇 – kinų kalbos vu tarmė" lang="wuu" hreflang="wuu" data-title="胆固醇" data-language-autonym="吴语" data-language-local-name="kinų kalbos vu tarmė" class="interlanguage-link-target"><span>吴语</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a 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<tbody><tr> <td> <span typeof="mw:File"><a href="/wiki/Vaizdas:NoFonti.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b5/NoFonti.svg/46px-NoFonti.svg.png" decoding="async" width="46" height="46" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b5/NoFonti.svg/69px-NoFonti.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b5/NoFonti.svg/92px-NoFonti.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span>  </td> <td><b>Šiam straipsniui ar jo daliai <a href="/wiki/Vikipedija:Patikrinamumas" title="Vikipedija:Patikrinamumas">trūksta išnašų į patikimus šaltinius</a>.</b><br /><small>Jūs galite padėti Vikipedijai pridėdami <a href="/wiki/Vikipedija:%C5%A0altini%C5%B3_nurodymas" class="mw-redirect" title="Vikipedija:Šaltinių nurodymas">tinkamas išnašas</a> su šaltiniais.</small> </td></tr></tbody></table> <table class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;"> <tbody><tr> <th align="center" style="border: 1px solid #C0C090; background-color: #F8EABA; margin-bottom: 3px;" colspan="2">Cholesterolis </th></tr> <tr> <td align="center" colspan="2" bgcolor="#ffffff"><span typeof="mw:File"><a href="/wiki/Vaizdas:Cholesterol.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Cholesterol.svg/200px-Cholesterol.svg.png" decoding="async" width="200" height="127" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Cholesterol.svg/300px-Cholesterol.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Cholesterol.svg/400px-Cholesterol.svg.png 2x" data-file-width="613" data-file-height="390" /></a></span> </td></tr> <tr> <th align="center" style="border: 1px solid #C0C090; background-color: #F8EABA; margin-bottom: 3px;" colspan="2">Bendra informacija </th></tr> <tr> <td><a href="/wiki/IUPAC_nomenklat%C5%ABra" title="IUPAC nomenklatūra">Sisteminis pavadinimas</a> </td> <td>10,13-dimetil-17-<br /> <p>(2,6-dimetilheptanil)-<br /> 2,3,4,7,8,9,11,12,14,15,16,17-<br /> dodekahidro-1H-<br /> ciklopenta[a]fenantren-3-olis </p> </td></tr> <tr> <td><a href="/wiki/Chemin%C4%97_formul%C4%97" title="Cheminė formulė">Cheminė formulė</a> </td> <td>C<sub>27</sub>H<sub>46</sub>O </td></tr> <tr> <td><a href="/wiki/Molin%C4%97_mas%C4%97" class="mw-redirect" title="Molinė masė">Molinė masė</a> </td> <td>386.65 g/mol </td></tr> <tr> <td><a href="/wiki/CAS_registracijos_numeris" title="CAS registracijos numeris">CAS numeris</a> </td> <td>[57-88-5] </td></tr> <tr> <td><a href="/wiki/Lydymosi_temperat%C5%ABra" title="Lydymosi temperatūra">Lydymosi temperatūra</a> </td> <td>146–147 °C </td></tr> <tr> <td>SMILES </td> <td><small>C[C@H]3C4[C@](CC[C@@H]4<br /> <p>[C@H](C)CCCC(C)C)([H])[C@]2<br /> ([H])CC=C1C[C@@H](O)CC[C@]1<br /> (C)[C@@]2([H])C3<small> </small></p><small> </small></small></td></tr></tbody></table> <p><b>Cholesterolis</b> (<b>cholesterinas</b>) – gyvūnų audinių steroidinis <a href="/wiki/Alkoholis" title="Alkoholis">alkoholis</a> C<sub>27</sub>H<sub>45</sub>OH. Cholesterolis <a href="/wiki/XVIII_am%C5%BEius" title="XVIII amžius">XVIII a.</a> išskirtas iš <a href="/wiki/Tul%C5%BEies_p%C5%ABsl%C4%97s_akmenlig%C4%97" title="Tulžies pūslės akmenligė">tulžies akmenų</a>. Aptinkamas beveik visose <a href="/wiki/%C5%BDmogus" title="Žmogus">žmogaus</a> ir <a href="/wiki/Gyv%C5%ABnas" class="mw-redirect" title="Gyvūnas">gyvūnų</a> <a href="/wiki/L%C4%85stel%C4%97" title="Ląstelė">ląstelėse</a>. Cholesterolis ir sintetinamas organizme, ir patenka į jį su maistu. Sutrikus cholesterolio metabolizmui, kraujagyslėse ima kauptis riebalinės kilmės nuosėdos, mažinančios kraujagyslių pralaidumą ir gebėjimą pulsuoti – išsivysto <a href="/wiki/Ateroskleroz%C4%97" title="Aterosklerozė">aterosklerozė</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Cholesterolio_de_novo_sintezė"><span id="Cholesterolio_de_novo_sintez.C4.97"></span>Cholesterolio <i>de novo</i> sintezė</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Cholesterolis&veaction=edit&section=1" title="Redaguoti skyrelį: Cholesterolio de novo sintezė" class="mw-editsection-visualeditor"><span>redaguoti</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Cholesterolis&action=edit&section=1" title="Edit section's source code: Cholesterolio de novo sintezė"><span>redaguoti vikitekstą</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Cholesterolis sintetinamas daugelyje žmogaus organizmo ląstelių, tačiau intensyviausiai jo sintezė vyksta kepenų ir žarnyno ląstelėse. Cholesterolis susidaro endoplazminiame tinkle ir citozolyje. Kaip ir riebalų rūgštys, sintetinamas iš citozolinio acetil-KoA, kuris susidaro <a href="/wiki/Mitochondrija" title="Mitochondrija">mitochondrijose</a> <a href="/wiki/Gliukoz%C4%97" title="Gliukozė">gliukozės</a>, riebalų rūgščių, <a href="/wiki/Aminor%C5%ABg%C5%A1tys" title="Aminorūgštys">aminorūgščių</a> katabolizmo metu. Iš <a href="/wiki/Mitochondrija" title="Mitochondrija">mitochondrijų</a> acetil-KoA į citozolį perneša citratas. Citratas citozolyje suskyla, susidaro oksaloacetatas ir acetil-KoA. Visą cholesterolio sintezę galima suskirstyti į kelias stadijas: </p> <ol><li>Mevalonato susidarymas iš acetil-KoA</li> <li>Mevalonato fosforilinimas, dekarboksilinimas ir aktyviojo izoprenoidinio vieneto susidarymas</li> <li>Šešių izoprenoidinių molekulių kondensacija ir tarpinio junginio skvaleno sintezė</li> <li>Skvaleno ciklizacija ir steroido lanosterolio susidarymas</li> <li>Lanosterolio virtimas cholesteroliu</li></ol> <div class="mw-heading mw-heading3"><h3 id="Mevalonato_susidarymas_iš_acetil-KoA"><span id="Mevalonato_susidarymas_i.C5.A1_acetil-KoA"></span>Mevalonato susidarymas iš acetil-KoA</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Cholesterolis&veaction=edit&section=2" title="Redaguoti skyrelį: Mevalonato susidarymas iš acetil-KoA" class="mw-editsection-visualeditor"><span>redaguoti</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Cholesterolis&action=edit&section=2" title="Edit section's source code: Mevalonato susidarymas iš acetil-KoA"><span>redaguoti vikitekstą</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Perneštos acetil-KoA molekulės iš mitochondrijų matrikso į citozolį kondensuojasi, veikiant <a href="/wiki/Fermentai" class="mw-redirect" title="Fermentai">fermentui</a> <i>tiolazei</i> (EC 2.3.1.9) ir susidaro acetoacetil-KoA ir atskyla KoA (<a href="/wiki/Kofermentas_A" title="Kofermentas A">kofermentas A</a>). Susidaręs acetoacetil-KoA gali būti panaudojamas <a href="/wiki/Ketonai" title="Ketonai">ketoninių kūnų</a> ir cholesterolio biosintezėje. </p><p>Toliau prie acetoacetil-KoA jungiasi dar viena acetil-KoA <a href="/wiki/Molekul%C4%97" title="Molekulė">molekulė</a>, veikiant fermentui <i>3-hidroksi-3-metilglutaril-CoA sinatzei</i> (EC 2.3.3.10). Susidaro 3-hidroksi-3-metilglutaril-CoA ir KoA </p><p>Katalizuojant mikrosominiam fermentui <i>3-hidroksi-3-metilglutaril-CoA reduktazei</i> (EC 1.1.1.34) ir dalyvaujant <a href="/wiki/NADPH" class="mw-redirect" title="NADPH">nikotinamido adenino dinukleotido fosfatui</a> (NADPH), redukuojama viena karboksigrupė, atskyla KoA ir susidaro mevalonato rūgštis. Tai pirmoji negrįžtama cholesterolio biosintezės reakcija. <i>3-hidroksi-3-metilglutaril-CoA reduktazė</i> vadinama cholesterolio biosintezės greitį reguliuojančiu fermentu. Ją inhibuoja cholesterolis ir <a href="/wiki/Grybai" title="Grybai">grybų</a> metabolitai: kompaktinas bei mevinolinas, konkuruojantys su <i>3-hidroksi-3-metilglutaril-CoA reduktaze</i>, taip pat <a href="/wiki/Vaistai" class="mw-redirect" title="Vaistai">vaistų</a> grupės šeima – statinai (lovastatinas, simvastatinas ir kt.) </p><p><span class="mw-default-size" typeof="mw:File"><a href="/wiki/Vaizdas:Mevalonatas.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/lt/4/4a/Mevalonatas.jpg" decoding="async" width="722" height="111" class="mw-file-element" data-file-width="722" data-file-height="111" /></a></span> </p> <div class="mw-heading mw-heading3"><h3 id="Mevalonato_fosforilinimas_ir_dekarboksilinimas">Mevalonato fosforilinimas ir dekarboksilinimas</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Cholesterolis&veaction=edit&section=3" title="Redaguoti skyrelį: Mevalonato fosforilinimas ir dekarboksilinimas" class="mw-editsection-visualeditor"><span>redaguoti</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Cholesterolis&action=edit&section=3" title="Edit section's source code: Mevalonato fosforilinimas ir dekarboksilinimas"><span>redaguoti vikitekstą</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Mevalono rūgštis (mevalonatas) fosforilinama dalyvaujant ATP (adenozintrifosfatas). Mevalonato fosforilinimą vykdo <a href="/wiki/Fermentas" title="Fermentas">fermentas</a> <i>mevalonatkinazė</i> (EC 2.7.1.36) – <a href="/wiki/Kofermentas" title="Kofermentas">kofermentas</a> magnio jonas. Susidaro 5-fosfomevalonatas. </p><p>5-fosfomevalonatas veikiant fermentui <i>fosfomevalonatkinazei</i> (EC 2.7.4.2), dalyvaujant <a href="/wiki/ATP" title="ATP">ATP</a> ir magnio jonams fosforilinmas iki 5,5-difosfomevalonato. Pastarąjį veikia <a href="/wiki/Fermentas" title="Fermentas">fermentas</a> <i>difosfomevalonatkinazė</i> ir susidaro 3,5,5- trifosfomevalonatas. Jis yra nestabilus ir, katalizuojant fermentui <i>difosfomevalonatdekarboksilazei</i> (EC 4.1.1.33) dekarboksilinamas. Susidaro izopentenildifosfatas – aktyvus izoprenoidinis vienetas ir anglies <a href="/wiki/Anglies_dioksidas" title="Anglies dioksidas">dioksido</a> <a href="/wiki/Molekul%C4%97" title="Molekulė">molekulė</a>. </p><p>Izopentenildifosfatas naudojamas ne tik tolimesnei cholesterolio sintezei, bet ir kitų izoprenoidinių junginių, tokių kaip <a href="/wiki/Vitaminas_A" title="Vitaminas A">vitamino A</a>, <a href="/wiki/Vitaminas_E" title="Vitaminas E">vitamino E</a>, <a href="/wiki/Vitaminas_K" title="Vitaminas K">vitamino K</a>, karotinoidų, fitolio, <a href="/wiki/Kau%C4%8Diukas" title="Kaučiukas">kaučiuko</a>, poliizoprenoidų (ubichinono, dolicholio) sintezei. </p><p><span class="mw-default-size" typeof="mw:File"><a href="/wiki/Vaizdas:Izopentenildifosfatas.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/lt/4/49/Izopentenildifosfatas.jpg" decoding="async" width="727" height="182" class="mw-file-element" data-file-width="727" data-file-height="182" /></a></span> </p> <div class="mw-heading mw-heading3"><h3 id="Izoprenoidinių_molekulių_kondensacija_ir_skvaleno_sintezė"><span id="Izoprenoidini.C5.B3_molekuli.C5.B3_kondensacija_ir_skvaleno_sintez.C4.97"></span>Izoprenoidinių molekulių kondensacija ir skvaleno sintezė</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Cholesterolis&veaction=edit&section=4" title="Redaguoti skyrelį: Izoprenoidinių molekulių kondensacija ir skvaleno sintezė" class="mw-editsection-visualeditor"><span>redaguoti</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Cholesterolis&action=edit&section=4" title="Edit section's source code: Izoprenoidinių molekulių kondensacija ir skvaleno sintezė"><span>redaguoti vikitekstą</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Procesas prasideda nuo izopentenildifosfato izomerizacijos (pasikeičia dvigubojo ryšio padėtis). Jis virsta 3,3-dimetilalildifosfatu, kuris kondensuojasi su kita izopentenildifosfato molekule, veikiant fermentui <i>dimetilaliltranstransferasei</i> (EC 2.5.1.1) ir susidaro junginys iš dešimties anglies atomų – geranildifosfatas ir difosfatas. Geranildifosfatas jungiasi dar su viena izopentenildifosfato molekule, veikiant fermentui <i>geraniltranstransferasei</i> (EC 2.5.1.10) ir susidaro 15 <a href="/wiki/Anglis" title="Anglis">anglies</a> atomų turintis junginys farnezildifosfatas (iš jo sintetinami poliizoprenoidi dolicholis, ubichinonas, menachinonas, plastochinonas). Tada, katalizuojant fermentui <i>skvalensintetazei</i> (EC 2.5.1.25), kondensuojsi dvi farnezildifosfato <a href="/wiki/Molekul%C4%97" title="Molekulė">molekulės</a> ir susidaro preskvalendifosfatas, kuris redukuojamas NADPH, atskiriant difosfatą. Susidaro skvalenas. </p><p><span class="mw-default-size" typeof="mw:File"><a href="/wiki/Vaizdas:Skvaleno_susidarymas.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/lt/4/41/Skvaleno_susidarymas.jpg" decoding="async" width="1048" height="344" class="mw-file-element" data-file-width="1048" data-file-height="344" /></a></span> </p> <div class="mw-heading mw-heading3"><h3 id="Skvaleno_ciklizacija_ir_lanosterolio_susidarymas">Skvaleno ciklizacija ir lanosterolio susidarymas</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Cholesterolis&veaction=edit&section=5" title="Redaguoti skyrelį: Skvaleno ciklizacija ir lanosterolio susidarymas" class="mw-editsection-visualeditor"><span>redaguoti</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Cholesterolis&action=edit&section=5" title="Edit section's source code: Skvaleno ciklizacija ir lanosterolio susidarymas"><span>redaguoti vikitekstą</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Prieš ciklizaciją, katalizuojant <a href="/wiki/Fermentas" title="Fermentas">fermentui</a> <i>skvaleno monooksigenazei</i> (skvalenepoksidazei, „mišriosios funkcijos oksidazei“) (EC 1.14.99.7), skvalenas <a href="/wiki/Endoplazminis_tinklas" title="Endoplazminis tinklas">endoplazminiame tinkle</a> virsta skvaleno-2,3-oksidu. Toliau katalizuojant fermentui <i>lanosterolio sintazei</i> (EC 5.4.99.7), pernašamos metilo grupės nuo 14 iki 13 ir nuo 8 prie 14 grupių. Skvaleno-2,3-oksidas ciklizuojasi ir susidaro lanosterolis. </p><p><span typeof="mw:File"><a href="/wiki/Vaizdas:Lanosterolio_susidarymas.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/lt/thumb/1/1a/Lanosterolio_susidarymas.jpg/1000px-Lanosterolio_susidarymas.jpg" decoding="async" width="1000" height="235" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/lt/1/1a/Lanosterolio_susidarymas.jpg 1.5x" data-file-width="1143" data-file-height="269" /></a></span> </p> <div class="mw-heading mw-heading3"><h3 id="Lanosterolio_virtimas_cholesteroliu">Lanosterolio virtimas cholesteroliu</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Cholesterolis&veaction=edit&section=6" title="Redaguoti skyrelį: Lanosterolio virtimas cholesteroliu" class="mw-editsection-visualeditor"><span>redaguoti</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Cholesterolis&action=edit&section=6" title="Edit section's source code: Lanosterolio virtimas cholesteroliu"><span>redaguoti vikitekstą</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Cholesterolio sintezė iš lanosterolio yra daugiastadijinis procesas susidedantis daugiau nei iš 20 reakcijų. Pradžioje vyksta anglies grandinės sutrumpėjimas nuo 30 iki 27 anglies atomų – metilo grupė esanti prie C-14 oksiduojama iki anglies dioksido, susidaro 14-demetillanosterolis. Panašiai pašalinus dar dvi metilo grupes nuo C-4 susidaro zimosterolis. Vėliau vyksta dvigubojo ryšio emigracija nuo C8 ir C9 iki C8 ir C7, susidarant Δ7,24 cholestadienoliui, veliau nuo C8 ir C7 iki C5 ir C6, susidarant desmosteroliui ir galiausiai dvigubo ryšio tarp C-24 ir C-25 redukcija, po kurios ir sudaro cholesterolis. </p><p><span class="mw-default-size" typeof="mw:File"><a href="/wiki/Vaizdas:Cholesterolio_susidarymas.gif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/lt/a/ae/Cholesterolio_susidarymas.gif" decoding="async" width="854" height="422" class="mw-file-element" data-file-width="854" data-file-height="422" /></a></span> </p><p><br /> </p> <div class="mw-heading mw-heading2"><h2 id="Literatūra"><span id="Literat.C5.ABra"></span>Literatūra</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Cholesterolis&veaction=edit&section=7" title="Redaguoti skyrelį: Literatūra" class="mw-editsection-visualeditor"><span>redaguoti</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Cholesterolis&action=edit&section=7" title="Edit section's source code: Literatūra"><span>redaguoti vikitekstą</span></a><span class="mw-editsection-bracket">]</span></span></div> <ol><li>R. Baltrušis, G. Dienys, V. Mickevičius, A. Šačkus, P. Vainilavičius. (1999) Organinė chemija (2 dalis). p. 167–168.</li> <li>A. Praškevičius, L. Ivanovienė, N. Stasiūnienė, J. Burneckienė, H. Radovičius „Biochemija“, leidykla „Vitae litera“, Kaunas 2006 m. <a href="/wiki/Specialus:Knyg%C5%B3_%C5%A1altiniai/9955686030" class="internal mw-magiclink-isbn">ISBN 9955-686-03-0</a></li></ol>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Rodomas puslapis "<a dir="ltr" href="https://lt.wikipedia.org/w/index.php?title=Cholesterolis&oldid=6757980">https://lt.wikipedia.org/w/index.php?title=Cholesterolis&oldid=6757980</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Specialus:Kategorijos" title="Specialus:Kategorijos">Kategorijos</a>: <ul><li><a href="/wiki/Kategorija:Angliavandeniai" title="Kategorija:Angliavandeniai">Angliavandeniai</a></li><li><a href="/wiki/Kategorija:Kraujotakos_sistema" title="Kategorija:Kraujotakos sistema">Kraujotakos sistema</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Paslėptos kategorijos: <ul><li><a href="/wiki/Kategorija:Straipsniai_be_%C5%A1altini%C5%B3_nenurodyta_nuo_kada" title="Kategorija:Straipsniai be šaltinių nenurodyta nuo kada">Straipsniai be šaltinių nenurodyta nuo kada</a></li><li><a href="/wiki/Kategorija:Straipsniai_be_%C5%A1altini%C5%B3_be_skydelio_datos" title="Kategorija:Straipsniai be šaltinių be skydelio datos">Straipsniai be šaltinių be skydelio datos</a></li><li><a href="/wiki/Kategorija:Straipsniai_be_%C5%A1altini%C5%B3" title="Kategorija:Straipsniai be šaltinių">Straipsniai be šaltinių</a></li><li><a href="/wiki/Kategorija:Puslapiai,_naudojantys_ISBN_magi%C5%A1kas_nuorodas" title="Kategorija:Puslapiai, naudojantys ISBN magiškas nuorodas">Puslapiai, naudojantys ISBN magiškas nuorodas</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> Šis puslapis paskutinį kartą keistas 26 lapkričio 2022 12:14.</li> <li id="footer-info-copyright">Tekstas pateikiamas pagal <a rel="nofollow" class="external text" href="//creativecommons.org/licenses/by-sa/4.0/">Creative Commons Attribution/Share-Alike Licenciją</a>; gali būti taikomos papildomos sąlygos. 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