Optimization of Radiation Therapy with a Nanotechnology Based Enzymatic Therapy

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Therapy with a Nanotechnology Based Enzymatic Therapy</title> <meta name="description" content="Optimization of Radiation Therapy with a Nanotechnology Based Enzymatic Therapy"> <meta name="keywords" content="D-amino Acid Oxidase (DAO) enzyme, magnetic particles, nanotechnology, radiation therapy enhancement"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img 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publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Optimization of Radiation Therapy with a Nanotechnology Based Enzymatic Therapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20D.%20Esposito">R. D. Esposito</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20M.%20Barber%C3%A1"> V. M. Barber谩</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Garc%C3%ADa%20Morales"> P. Garc铆a Morales</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Dorado%20Rodr%C3%ADguez"> P. Dorado Rodr铆guez</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Sanz"> J. Sanz</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Fuentes"> M. Fuentes</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Planes%20Meseguer"> D. Planes Meseguer</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Saceda"> M. Saceda</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20Fern%C3%A1ndez%20Fornos"> L. Fern谩ndez Fornos</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20P.%20Ventero"> M. P. Ventero</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Results obtained by our group on glioblastoma multiforme (GBM) primary cultures , show a dramatic potentiation of radiation effects when 2 units/ml of D-amino acid oxidase (DAO) enzyme are added, free or immobilized in magnetic nanoparticles, to irradiated samples just after the irradiation. Cell cultures were exposed to radiation doses of 7Gy and 15Gy of 6 MV photons from a clinical linear accelerator. At both doses, we observed a clear enhancing effect of radiation-induced damages due to the addition of DAO. <iframe src="https://publications.waset.org/abstracts/29814.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=D-amino%20Acid%20Oxidase%20%28DAO%29%20enzyme" title="D-amino Acid Oxidase (DAO) enzyme">D-amino Acid Oxidase (DAO) enzyme</a>, <a href="https://publications.waset.org/abstracts/search?q=magnetic%20particles" title=" magnetic particles"> magnetic particles</a>, <a href="https://publications.waset.org/abstracts/search?q=nanotechnology" title=" nanotechnology"> nanotechnology</a>, <a href="https://publications.waset.org/abstracts/search?q=radiation%20therapy%20enhancement" title=" radiation therapy enhancement"> radiation therapy enhancement</a> </p> <a 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Optimization of Radiation Therapy with a Nanotechnology Based Enzymatic Therapy