TNF-alpha Products

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <noscript><style>form.antibot * :not(.antibot-message) { display: none !important; }</style> </noscript><meta name="applicable-device" content="pc,mobile" /> <link rel="canonical" href="https://www.bio-techne.com/t/tnf-alpha?species=Primate|Cynomolgus" /> <meta property="og:site_name" content="Bio-Techne" /> <meta property="og:type" content="Website" /> <meta property="og:url" content="https://www.bio-techne.com/" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <script type="application/ld+json">{ "@context": "https://schema.org", "@graph": [ { "@type": "WebPage", "@id": "https://www.bio-techne.com/t/tnf-alpha", "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://www.bio-techne.com/" } ] } } ] }</script> <meta http-equiv="x-dns-prefetch-control" content="on" /> <meta http-equiv="x-ua-compatible" content="ie=edge" /> <meta name="description" content="View 5 TNF-alpha products. Bio-Techne offers high-quality reagents, instruments, custom manufacturing and testing services." /> <meta name="robots" content="noindex, nofollow" /> <link rel="icon" href="/themes/custom/bio_techne_global/favicon.ico" type="image/vnd.microsoft.icon" /> <link rel="preconnect" href="https://resources.bio-techne.com" /> <link rel="preconnect" href="https://resources.tocris.com" /> <link rel="preconnect" href="https://i.icomoon.io" /> <link rel="preconnect" href="https://cdn.icomoon.io" /> <link rel="dns-prefetch" href="https://connect.facebook.net" /> <link rel="dns-prefetch" href="https://resources.bio-techne.com" /> <link rel="dns-prefetch" href="https://snap.licdn.com" /> <link rel="dns-prefetch" href="https://www.google-analytics.com" /> <link rel="dns-prefetch" href="https://munchkin.marketo.net" /> <link rel="dns-prefetch" href="https://resources.tocris.com" /> <link rel="dns-prefetch" href="https://i.icomoon.io" /> <link rel="dns-prefetch" href="https://cdn.icomoon.io" /> <title>TNF-alpha Products</title> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_xjKUVyejREpIQpQXk9gHxlqgAggu86kEHbu2DYYV1Uo.css?delta=0&language=en&theme=bio_techne_global&include=eJx9kFGOwzAIRC8U10eysEMdFAJZTHaV29dt2rQ_2y_gDUIzGLZVpdEvJofMmK7Ejhbt5OHBh7Y3xyVmaDhk0uRYJsFUWTNwPEpovjNJHYrqTJhEna5UwEklHix8spBZyzyspuNWPDUEK1M8SuoONvbWby0LWsH4agJTNrD9rqxg3bgqx88hVfAJDe08fVdVULzFJwqCf4GKyrcdWqDit4VuRMbAWvWfFBnsTJB-Niqz2tj_e4Z5s8vjGzcXeZ8j" /> <link rel="stylesheet" media="all" href="/sites/default/files/css/css_d9gn2GRzRb_AMxXfgjVqY5zLMXvuwkXc1qKvoeAAIxE.css?delta=1&language=en&theme=bio_techne_global&include=eJx9kFGOwzAIRC8U10eysEMdFAJZTHaV29dt2rQ_2y_gDUIzGLZVpdEvJofMmK7Ejhbt5OHBh7Y3xyVmaDhk0uRYJsFUWTNwPEpovjNJHYrqTJhEna5UwEklHix8spBZyzyspuNWPDUEK1M8SuoONvbWby0LWsH4agJTNrD9rqxg3bgqx88hVfAJDe08fVdVULzFJwqCf4GKyrcdWqDit4VuRMbAWvWfFBnsTJB-Niqz2tj_e4Z5s8vjGzcXeZ8j" /> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"t\/tnf-alpha","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en","currentQuery":{"species":"Primate|Cynomolgus"}},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"gtm":{"tagId":null,"settings":{"data_layer":"dataLayer","include_environment":false},"tagIds":["GTM-N2MWQDR"]},"gtag":{"tagId":"","consentMode":false,"otherIds":[],"events":[],"additionalConfigInfo":[]},"ajaxPageState":{"libraries":"eJyVk1Fy4yAMhi8E5UiMAAWzwcgr5LTu6Ve2YyfbZjuzLxZ8ErL0I0IhLxiHhj5XClBdIJIuDJOPqZnwzb8b22WppeUXASXSSPTqaIXPxVaCtPrurlpu6CFjE3dCu0K7QV0GBl5MWA-7tBndEI2MEAc_lQ-sLoFAhQXZTnMfkE0Qj22AFjF51IJG5IguiD2oPantCBwHy9jnKt3iTf_7fwmK4HtJuB_t5gw_I3YBXjiO9g7gf88lXokT8iPowd6083hdoydg9EJU3fPGZxBtXwWIRNeCvpGUS4kghZrbmX1mdk946ucCDnArxN1ghS4l-klT-rkje4iRZm3Q3Rcqmczc7KRXpZ20q8lEuWopkF3Wz9f9G_yCj7_haEoT5LZVA7V8HqVqfl70bipG2au0U4WIA1UVwkxMaY7i1-6prbK7PE42QMr4ynlHVuVuSYcw009RZYSf0zR8tzro7YzZh8jtxgfgf3juU2bUas6-Tr9AUDkupaoO7sHtxk1fuuDoAnQ02y2UdiEed5lWYJ_A8Sz_AKFDgoE","theme":"bio_techne_global","theme_token":null},"ajaxTrustedUrl":[],"dataLayer":{"defaultLang":"en","languages":{"en":{"id":"en","name":"English","direction":"ltr","weight":0},"zh-hans":{"id":"zh-hans","name":"Chinese, Simplified","direction":"ltr","weight":1},"ja":{"id":"ja","name":"Japanese","direction":"ltr","weight":2}}},"internationalization":{"origin":{"id":"sg","label":"SG","country_name":"Singapore","alternate_spellings":"SG","country_enabled":true,"country_encased":false,"commerce_enabled":false,"credit_cards_enabled":true,"region":"North America - ROW","currency":"USD","localities":"","phone_pattern":"","country_shipping":"0","shipping_delay":3,"country_contact_message":"","product_block_message":"","default_language_setting":"none","default_contact_email":""},"languagePrefix":"\/"},"bloomreach_pixel":{"br_info":{"acct_id":"6368","domain_key":"biotechne"},"page_info":{"ptype":"other"},"order_info":{"order_id":""},"user_info":{"uid":0},"searchbar":{"enabled":"1","form":".product-search-form","input":"#edit-keywords"},"atc":{"enabled":"1","form":".add-to-cart-block"}},"user":{"uid":0,"permissionsHash":"085655eba91c5b5dd7808236555504ceb824f9fddd71e3c0265b4003df711142"}}</script> <script src="/sites/default/files/js/js_VXwrJf_GoEAY9I4SWeDh30VrU0-JgQhDzf_eoQcyzA4.js?scope=header&delta=0&language=en&theme=bio_techne_global&include=eJyVUu1yxCAIfCGpj-SgocaekQySa9OnL0kumevHn_5CFmdZFmJhpTQ2CrXcKWCmpj6eIGwg7KA9o6CsbkDFiiuJjzTivbB0RxW7lhRm1DEsnSRgSrw07f7xACFdpMFsZEbVbs6ahEfrXDli9ZFZuwrOIQ3tj_oRoOtqBNll5lwpKGafdfqeYv6Zv-AbfriogdqILdEQKPE0kSTyUeFE4UKhF6X3MhDQ3ebv7vp-_TgEWYFvhUJjLa8loRZu_sDgGYNYOd3cLDwsSUMnlDT6IwShvlRrEit-rn7Yw__U7jzw4Dk0_yH53KIBM4rZw1z9cxKy7ZCE5BK6VbltFvgHBGWyNZpW5kkITf5cPqj66zRgXvr4RPF91ojiSlOStvuCtXyeptmlyGqzVLIuu18wV0w0ch2M7_dNbD5BZRzcfnalvbJMB9sGwBNwHs4XCH4oTw"></script> <script src="/modules/contrib/google_tag/js/gtm.js?snbwxk"></script> <script src="/modules/contrib/google_tag/js/gtag.js?snbwxk"></script> <script src="/sites/default/files/js/js_noO6VL3JUON9fTBkbqcAjEkLsfpTqx94dWIfXpNxuMg.js?scope=header&delta=3&language=en&theme=bio_techne_global&include=eJyVUu1yxCAIfCGpj-SgocaekQySa9OnL0kumevHn_5CFmdZFmJhpTQ2CrXcKWCmpj6eIGwg7KA9o6CsbkDFiiuJjzTivbB0RxW7lhRm1DEsnSRgSrw07f7xACFdpMFsZEbVbs6ahEfrXDli9ZFZuwrOIQ3tj_oRoOtqBNll5lwpKGafdfqeYv6Zv-AbfriogdqILdEQKPE0kSTyUeFE4UKhF6X3MhDQ3ebv7vp-_TgEWYFvhUJjLa8loRZu_sDgGYNYOd3cLDwsSUMnlDT6IwShvlRrEit-rn7Yw__U7jzw4Dk0_yH53KIBM4rZw1z9cxKy7ZCE5BK6VbltFvgHBGWyNZpW5kkITf5cPqj66zRgXvr4RPF91ojiSlOStvuCtXyeptmlyGqzVLIuu18wV0w0ch2M7_dNbD5BZRzcfnalvbJMB9sGwBNwHs4XCH4oTw"></script> </head> <body> <a href="#main-content" class="visually-hidden focusable"> Skip to main content </a> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-N2MWQDR" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div id="page-wrapper"> <div id="page"> <header id="header" class="header" role="banner" aria-label="Site header"> <div class="section layout-container clearfix"> <section id="site-header__top"> <div class="container-fluid container-wide"> <div class="row m___navigation-utility-top"> <div class="col-xl-2 col-lg-12 text-xl-left text-lg-center"> <div id="site-header__logo" class="valign d-none d-lg-block mb-md-3"> <div> <div id="block-sitebranding" class="site-branding system_branding_block"> <a href="/" title="Home" rel="home" class="site-branding__logo"> <img width="160" height="28" src="/themes/custom/bio_techne_global/logo.svg" alt="Home" /> </a> </div> </div> </div> </div> <div class="col d-none d-xl-block text-lg-left text-md-center"> <div class="utility-bar-tagline rotating-text position-absolute"> <p class="ml-xl-4 bt-px_groteskbold text-white mb-0"> Global Developer, Manufacturer, and Supplier of High-Quality<br/> Reagents, Analytical Instruments, and Precision Diagnostics. </p> </div> <div class="utility-bar-brands rotating-text position-absolute ml-xl-4 text-white mb-0"> <div class="row"> <div class="col-2"> <div class="bt-px_groteskbold valign utility-bar-includes">INCLUDES</div> </div> <div class="col-lg-10 col-md-auto bt-inter"> <span class="mr-3">R&D Systems<sup>TM</sup></span> <span class="mr-3">Novus Biologicals<sup>TM</sup></span> <span class="mr-3">Tocris Bioscience<sup>TM</sup></span><br/> <span class="mr-3">ProteinSimple<sup>TM</sup></span> <span class="mr-3">ACD<sup>TM</sup></span> <span class="mr-3">ExosomeDx<sup>TM</sup></span> <span class="mr-3">Asuragen<sup style="font-size:11px;">®</sup></span> <span>Lunaphore<sup>TM</sup></span> </div> </div> </div> </div> <div class="col-xl-auto col-lg-12"> <div class="row"> <div class="col text-xl-left text-center"> </div> </div> <div class="row"> <div class="col text-xl-left text-center"> <nav id="site-header-top__left m___navigation-language"> <div> <div id="block-i18ncountryselect" class="i18n_country_select"> <div id="country-select-block-placeholder"> <div id="country-select-block-spinner" class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> </div> </div> </div> </nav> </div> </div> </div> </div> </div> </section> <div id="header-bg" class="bg-bt-secondary"> <section id="site-header__middle"> <div class="container-fluid container-wide"> <div class="row search-row"> <div id="hamburger-col" class="col-3 col-sm-3 col-md-2 d-block d-lg-none"> <button class="navbar-toggler collapsed" type="button" data-toggle="collapse" data-target="#navbarSupportedContent" aria-controls="navbarSupportedContent" aria-expanded="false" aria-label="Toggle navigation"> <span class="icon-bar top-bar"></span> <span class="icon-bar middle-bar"></span> <span class="icon-bar bottom-bar"></span> </button> </div> <div class="col-6 col-sm-6 col-md-8 d-block d-lg-none text-center"> <div id="site-header__logo" class="vertical-align mb-3"> <div> <div id="block-sitebranding" class="site-branding system_branding_block"> <a href="/" title="Home" rel="home" class="site-branding__logo"> <img width="160" height="28" src="/themes/custom/bio_techne_global/logo.svg" alt="Home" /> </a> </div> </div> </div> </div> <div id="tools-col" class="col-3 col-md-12 col-lg-auto order-sm-1 order-md-12 order-lg-12"> <div id="site-header__tools" class="vertical-align"> <div class="row"> <div class="col-md-12"> <div class="d-flex justify-content-end justify-content-md-center justify-content-lg-end"> <div class="text-right order-3 cart-not-available user_cart_information_block" id="block-biotechnecartinformation"> <span ></span> </div> <div class="mr-3 d-none d-md-block order-2 block-quickorderblock quick_order_block" id="block-quickorderblock"> </div> <div class="mr-3 order-1 user_account_information_block" id="block-biotechneuserinformation"> <a class="btn btn-primary" rel="nofollow" href="/account/login" role="button"> <span class="icon icon-bt-icon-user"></span> Sign In / Register </a> </div> </div> </div> </div> </div> </div> <div class="col order-sm-12 order-md-1 order-lg-1"> <div id="site-header__search">  <section role="search" class="vertical-align"> <div> <div class="block-product-search-form-block product_search_form_block" id="block-product-search-form-block"> <div class="row"> <div class="col-sm-12 search-bar mb-md-4"> <form class="product-search-form" action="/search" method="get" id="product-search-form" accept-charset="UTF-8" data-date="2024-11-23 12:11:22"> <div class="container-inline input-group" id="edit-container"> <div class="js-form-type-select"> <select class="dropdown-select text-dark-gray js-search-section-dropdown mr-2 pl-4 pr-5" id="edit-search-type" name="search_type" aria-label="Select search type"> <option value="products">Products</option> <option value="resources">Resources</option> </select> </div> <input placeholder="Search keyword, molecule name, target, catalog number, or product type..." autocomplete="off" class="form-control js-search-bar form-autocomplete form-text required ui-autocomplete-input" title="Search keyword, molecule name, target, catalog number, or product type..." data-autocomplete-path="/ajax/product-search/auto-suggest" type="text" id="product-search-keywords" name="keywords" value="" size="60" maxlength="256" required="required" aria-required="true" data-once="autocomplete" spellcheck="false"> <div class="form-actions" id="edit-actions"> <div class="input-group-append"> <input class="form-submit" type="submit" value=""> </div> </div> </div> </form> </div> </div> </div> </div> </section> </div> </div> </div> </div> </section> <section id="site-header__bottom"> <div class="container-fluid container-wide"> <div class="row"> <div class="col-md-12">  <nav id="main-nav"> <div> <div id="block-bio-techne-global-mainmenublock" class="main_menu_block"> <nav role="navigation" aria-labelledby="block-main-menu" id="block-main-menu" class="contextual-region navbar navbar-expand-md navbar-dark"> <div class="collapse navbar-collapse" id="navbarSupportedContent" data-date="2024-11-22 05:11:30"> <ul class="navbar-nav ml-auto"> <li class="nav-item dropdown d-md-none"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-quick-order" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Quick Order <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-quick-order" aria-labelledby="navbarDropdown-quick-order"> <div class="row"> <a href="/commerce/quickorder" class="dropdown-item text-wrap" title="Quick order form" data-drupal-link-system-path="commerce/quickorder">Quick Order Form</a> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-research-products" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Research Products <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-research-products" aria-labelledby="navbarDropdown-research-products"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Reagents & Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/reagents/antibodies" class="dropdown-item text-wrap" data-drupal-link-system-path="node/276">Antibodies</a> <a href="/reagents/cell-culture-reagents" class="dropdown-item text-wrap" data-drupal-link-system-path="node/156">Cell Culture Reagents</a> <a href="/reagents/compound-libraries" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1096">Compound Libraries</a> <a href="/reagents/elisa-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/176">ELISA Kits</a> <a href="/reagents/elispot-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/141">ELISpot Kits</a> <a href="/reagents/enzymes" class="dropdown-item text-wrap" data-drupal-link-system-path="node/246">Enzymes</a> <a href="/reagents/fluorescent-dyes-probes" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6191">Fluorescent Dyes and Probes</a> <a href="/reagents/luminex-assays" class="dropdown-item text-wrap" data-drupal-link-system-path="node/181">Luminex Assays</a> <a href="/reagents/proteins" class="dropdown-item text-wrap" data-drupal-link-system-path="node/236">Proteins</a> <a href="/reagents/proteome-profiler-antibody-arrays" class="dropdown-item text-wrap" data-drupal-link-system-path="node/206">Proteome Profiler Antibody Arrays</a> <a href="/reagents/rnascope-ish-technology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1626">RNAscope ISH Probes & Assays</a> <a href="/reagents/simple-plex-immunoassays" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1531">Simple Plex Immunoassays</a> <a href="/reagents/small-molecules-and-peptides" class="dropdown-item text-wrap" data-drupal-link-system-path="node/371">Small Molecules & Inhibitors</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> GMP Products<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/gmp-products/gmp-proteins" class="dropdown-item text-wrap" data-drupal-link-system-path="node/511">GMP Proteins</a> <a href="/gmp-products/gmp-small-molecules" class="dropdown-item text-wrap" data-drupal-link-system-path="node/366">GMP Small Molecules</a> <a href="/gmp-products/gmp-antibodies" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13266">GMP Antibodies</a> <a href="/gmp-products/gmp-capabilities" class="dropdown-item text-wrap" title="GMP Capabilities" data-drupal-link-system-path="node/1071">GMP Capabilities</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instruments<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/brands/proteinsimple" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3281">ProteinSimple Instruments</a> <a href="/instruments/ice" title="Our capillary electrophoresis instruments (icIEF and CE-SDS) provide reproducible quantitative analysis for thorough therapeutic protein characterization." class="dropdown-item text-wrap" data-drupal-link-system-path="node/256">iCE Maurice</a> <a href="/instruments/imagers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/536">Imagers</a> <a href="/instruments/luminex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/241">Luminex</a> <a href="/instruments/micro-flow-imaging" class="dropdown-item text-wrap" data-drupal-link-system-path="node/526">Micro-Flow Imaging</a> <a href="/instruments/simple-plex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/541">Simple Plex Ella</a> <a href="/instruments/simple-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/521">Simple Western</a> <a href="/instruments/single-cell-dispensers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6361">Single Cell Dispensers</a> <a href="/instruments/single-cell-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/531">Single-Cell Western</a> <a href="/instruments" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6731">View All Instruments</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Applications<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/methods/bioprocessing" class="dropdown-item text-wrap">Bioprocessing</a> <a href="/applications/crispr" class="dropdown-item text-wrap" data-drupal-link-system-path="node/9356">CRISPR</a> <a href="/applications/electrophysiology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/426">Electrophysiology</a> <a href="/applications/flow-cytometry" class="dropdown-item text-wrap" data-drupal-link-system-path="node/321">Flow Cytometry</a> <a href="/applications/imaging" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10181">Imaging </a> <a href="/applications/immunoassays" class="dropdown-item text-wrap" data-drupal-link-system-path="node/496">Immunoassays</a> <a href="/resources/instrument-applications" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3341">Instrument Applications</a> <a href="/applications/mass-cytometry" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10071">Mass Cytometry (CyTOF)</a> <a href="/applications/spatial-biology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13416">Spatial Biology</a> <a href="/applications/vaccine-development" class="dropdown-item text-wrap" data-drupal-link-system-path="node/566">Vaccine Development</a> <a href="/applications/western-blotting" class="dropdown-item text-wrap" data-drupal-link-system-path="node/281">Western Blotting</a> <a href="/applications" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6736">View All Applications</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Research Areas<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/research-areas/cancer" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8791">Cancer</a> <a href="/research-areas/cell-biology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10661">Cell Biology</a> <a href="/research-areas/cell-and-gene-therapy" class="dropdown-item text-wrap" data-drupal-link-system-path="node/51">Cell & Gene Therapy</a> <a href="/research-areas/coronavirus" class="dropdown-item text-wrap" data-drupal-link-system-path="node/576">COVID-19</a> <a href="/research-areas/epigenetics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/9511">Epigenetics</a> <a href="/research-areas/hypoxia" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8846">Hypoxia</a> <a href="/research-areas/immunology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10601">Immunology</a> <a href="/research-areas/immuno-oncology" class="dropdown-item text-wrap" data-drupal-link-system-path="node/381">Immuno-Oncology</a> <a href="/research-areas/metabolism" class="dropdown-item text-wrap" data-drupal-link-system-path="node/406">Metabolism</a> <a href="/research-areas/neuroscience" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10591">Neuroscience</a> <a href="/research-areas/organoids-3d-culture" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1452">Organoid and 3-D Culture</a> <a href="/research-areas/stem-cells" class="dropdown-item text-wrap" data-drupal-link-system-path="node/161">Stem Cells</a> <a href="/research-areas/targeted-protein-degradation" class="dropdown-item text-wrap" data-drupal-link-system-path="node/376">Targeted Protein Degradation</a> <a href="/research-areas" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6741">View All Research Areas</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-therapeutic-manufacturing" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Therapeutic Manufacturing <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-therapeutic-manufacturing" aria-labelledby="navbarDropdown-therapeutic-manufacturing"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Reagents & Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/reagents/cell-culture-reagents/serum-free-animal-free" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3576">Animal-Free Cell Culture</a> <a href="/reagents/elisa-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/176">ELISA Kits</a> <a href="/therapeutic-manufacturing/simple-plex-assays" class="dropdown-item text-wrap" title="Bioprocess impurities and immunotitration" data-drupal-link-system-path="node/1311">Simple Plex Immunoassays</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> GMP Products<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/gmp-products/gmp-proteins" class="dropdown-item text-wrap" data-drupal-link-system-path="node/511">GMP Proteins</a> <a href="/gmp-products/gmp-small-molecules" class="dropdown-item text-wrap" data-drupal-link-system-path="node/366">GMP Small Molecules</a> <a href="/gmp-products/gmp-antibodies" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13266">GMP Antibodies</a> <a href="/gmp-products/gmp-capabilities" class="dropdown-item text-wrap" title="GMP Capabilities" data-drupal-link-system-path="node/1071">GMP Capabilities</a> <a href="/gmp-products/ruo-to-gmp" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3421">Transition to GMP </a> <a href="/gmp-products/loa-request" class="dropdown-item text-wrap" data-drupal-link-system-path="node/13326">DMF/LOA Request</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instruments<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/brands/proteinsimple" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3281">ProteinSimple Instruments</a> <a href="/instruments/ice" class="dropdown-item text-wrap" data-drupal-link-system-path="node/256">iCE Maurice</a> <a href="/instruments/imagers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/536">Imagers</a> <a href="/instruments/luminex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/241">Luminex</a> <a href="/instruments/micro-flow-imaging" class="dropdown-item text-wrap" data-drupal-link-system-path="node/526">Micro-Flow Imaging</a> <a href="/instruments/simple-plex" class="dropdown-item text-wrap" data-drupal-link-system-path="node/541">Simple Plex Ella</a> <a href="/instruments/simple-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/521">Simple Western</a> <a href="/instruments/single-cell-dispensers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6361">Single Cell Dispensers</a> <a href="/instruments/single-cell-western" class="dropdown-item text-wrap" data-drupal-link-system-path="node/531">Single Cell Western</a> <a href="/instruments" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6731">View All Instruments</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Applications<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/methods/bioprocessing" class="dropdown-item text-wrap">Bioprocessing</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Research Areas<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/research-areas/cell-and-gene-therapy" class="dropdown-item text-wrap" data-drupal-link-system-path="node/51">Cell & Gene Therapy</a> <a href="/applications/immuno-oncology-clinical" class="dropdown-item text-wrap" data-drupal-link-system-path="node/2066">Immuno-Oncology</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-diagnostics" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Diagnostics <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-diagnostics" aria-labelledby="navbarDropdown-diagnostics"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Controls & Reagents<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/clinical-quality-controls" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7606">Clinical Quality Controls</a> <a href="/diagnostics/molecular-quality-controls" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5596">Molecular Controls</a> <a href="/diagnostics/controls-reagents/rnascope-ish-probe-high-risk-hpv" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5981">RNAscope™ ISH Probe High Risk HPV</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Kits<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/amplidex-genetic-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5581">Genetics</a> <a href="/diagnostics/quantidex-oncology-testing-kits" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5586">Oncology</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Technology<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/exosome" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5486">Exosome Platform</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> OEM Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/ivd-assay-development" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10881">IVD Assay Development</a> <a href="/diagnostics/ivd-contract-manufacturing" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7381">IVD Contract Manufacturing</a> <a href="/diagnostics/molecular-quality-controls/oem-and-commercial-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6781">Molecular Diagnostic OEM Services</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Companion Diagnostics<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/diagnostics/companion-diagnostics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5631">Companion Diagnostics Services</a> <a href="/diagnostics/companion-diagnostics/multiomics" class="dropdown-item text-wrap" data-drupal-link-system-path="node/10616">Multiomics Platform</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-services" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Services <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-services" aria-labelledby="navbarDropdown-services"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom Quotes<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/bulk-quotes" class="dropdown-item text-wrap" data-drupal-link-system-path="services/bulk-quotes">Bulk Quote Discounts</a> <a href="/services/custom-formulation" class="dropdown-item text-wrap" data-drupal-link-system-path="services/custom-formulation">Custom Formulation Quotes</a> <a href="/reagents/rnascope-ish-technology/probes/custom" class="dropdown-item text-wrap" data-drupal-link-system-path="node/12571">RNAscope Custom Probe Design Quote</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Custom Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/custom-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1891">All Custom Services</a> <a href="/services/custom-antibody-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/906">Custom Antibody Services</a> <a href="/services/custom-cell-and-gene-therapy-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1281">Custom Cell & Gene Therapy Services</a> <a href="/services/custom-compound-library-service" class="dropdown-item text-wrap" data-drupal-link-system-path="node/2126">Custom Compound Library Services</a> <a href="/services/custom-elisa-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/261">Custom ELISA Services</a> <a href="/services/gene-engineering-services-tcbuster" class="dropdown-item text-wrap" title="Gene Engineering Services: Bio-Techne" data-drupal-link-system-path="node/1136">Custom Gene Engineering Services</a> <a href="/services/custom-luminex-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/271">Custom Luminex Services</a> <a href="/services/custom-protein-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1441">Custom Protein Services</a> <a href="/services/custom-simple-plex-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6296">Custom Simple Plex Services</a> <a href="/services/custom-targeted-protein-degradation-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/861">Custom Targeted Protein Degradation Services</a> <a href="/services/professional-assay-services-rnascope" class="dropdown-item text-wrap" data-drupal-link-system-path="node/12306">RNAscope Professional Assay Services</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instrument Services<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/certified-service-provider-program" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5446">Certified Service Provider (CSP) Program</a> <a href="/resources/instrument-services" class="dropdown-item text-wrap" data-drupal-link-system-path="node/5471">Contract Services</a> <a href="/services/instrument-services/simple-western-service-plans" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3181">Simple Western Service Plans</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Licensing<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/services/biotechnology-licensing-partnering" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1101">Biotechnology Licensing and Partnering</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-resources" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> Resources <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-resources" aria-labelledby="navbarDropdown-resources"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Product & Instrument Tools<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/cofa-finder-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/cofa-finder-tool">Certificate of Analysis (COA) Finder Tool</a> <a href="/resources/calculators" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7416">Calculators</a> <a href="/resources/flow-cytometry-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8821">Flow Cytometry Panel Builder</a> <a href="/luminex-assay-customization-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="luminex-assay-customization-tool">Luminex Assay Customization Tool</a> <a href="/resources/product-insert-lookup-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/product-insert-lookup-tool">Product Insert Lookup Tool</a> <a href="/resources/rnascope-citations" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/rnascope-citations">RNAscope Citations</a> <a href="/resources/simple-plex-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/simple-plex-panel-builder">Simple Plex Panel Builder</a> <a href="/resources/simple-western-kit-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/simple-western-kit-builder">Simple Western Kit Builder</a> <a href="/resources/simple-western-antibody-database" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/simple-western-antibody-database">Simple Western Antibody Database</a> <a href="/resources/single-cell-western-antibody-database" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/single-cell-western-antibody-database">Single-Cell Western Antibody Database</a> <a href="/resources/spectra-viewer" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6176">Spectra Viewer</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Scientific Resources<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/blogs" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/blogs">Blogs</a> <a href="/resources/literature" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/literature">Literature</a> <a href="/resources/podcasts/biotech-podcast-back-of-the-napkin" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8601">Podcasts</a> <a href="/resources/protocols-troubleshooting" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/protocols-troubleshooting">Protocols & Troubleshooting</a> <a href="/resources/scientific-articles" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/scientific-articles">Scientific Articles</a> <a href="/resources/signal-transduction-pathways" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/signal-transduction-pathways">Signal Transduction Pathways</a> <a href="/resources/testimonials" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/testimonials">Testimonials & Interviews</a> <a href="/resources/webinars" class="dropdown-item text-wrap" data-drupal-link-system-path="node/1596">Webinars</a> <a href="/resources/videos" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/videos">Videos</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Instrument Resources<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/instrument-applications" class="dropdown-item text-wrap" data-drupal-link-system-path="node/3341">Instrument Applications</a> <a href="/resources/instrument-citations" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/instrument-citations">Instrument Citations</a> <a href="/resources/protocols" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/protocols">Instrument Protocols</a> <a href="/resources/instrument-software-download-center" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/instrument-software-download-center">Instrument Software</a> </div> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="navbarDropdown-about" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"> About <span class="icon-bt-icon-caret-cropped menu-caret js-caret d-inline-block"></span> </a> <div class="dropdown-menu dropdown-menu-about" aria-labelledby="navbarDropdown-about"> <div class="row"> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> About Us<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/welcome-to-bio-techne" class="dropdown-item text-wrap" data-drupal-link-system-path="node/876">Welcome to Bio-Techne.com!</a> <a href="/about/about-bio-techne" class="dropdown-item text-wrap" data-drupal-link-system-path="node/16">About Bio-Techne</a> <a href="/brands" class="dropdown-item text-wrap" data-drupal-link-system-path="node/46">Bio-Techne Brands</a> <a href="/about/corporate-and-social-responsibility" class="dropdown-item text-wrap" data-drupal-link-system-path="node/61">Corporate & Social Responsibility</a> <a href="https://investors.bio-techne.com/" target="_blank" class="dropdown-item text-wrap">Investor Relations</a> <a href="/about/quality" class="dropdown-item text-wrap" data-drupal-link-system-path="node/6056">Quality</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Latest at Bio-Techne<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/about/careers" class="dropdown-item text-wrap" data-drupal-link-system-path="node/21">Careers</a> <a href="/about/events" class="dropdown-item text-wrap" data-drupal-link-system-path="node/786">Events</a> <a href="/programs" class="dropdown-item text-wrap" data-drupal-link-system-path="node/4621">Programs & Promotions</a> </div> </div> </div> <div class="col sub-menu-wrapper"> <div class="sub-menu-header"> Support<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/support/contact-us" class="dropdown-item text-wrap" data-drupal-link-system-path="node/96">Contact & Support</a> <a href="/distributors" class="dropdown-item text-wrap" data-drupal-link-system-path="node/9936">Distributors</a> </div> </div> </div> </div> </div> </li> </ul> </div> </nav> </div> </div> </nav> </div> </div> </div> </section> </div> </div> </header> </div> <div class="highlighted"> <aside class="container section clearfix" role="complementary"> <div> </div> </aside> </div> <div id="main" class="container-fluid container-wide "> <div class="row"> <div class="col-md-12"> <div> <div id="block-bio-techne-global-breadcrumbs" class="system_breadcrumb_block"> <nav role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/">Home</a> </li> <li> Products </li> <li> TNF-alpha Products </li> </ol> </nav> </div> </div> </div> </div> <div class="row"> <div class="col-md-12"> <main> <section class="section"> <div> <div id="block-bio-techne-global-content" class="system_main_block"> <div id="search_results_page"> <div class="d-sm-block d-xs-block d-lg-none d-xl-none"> <div class="d-lg-none"> <h1>TNF-alpha Products</h1> <div class="show-more" data-text="<p>TNF-alpha (Tumor necrosis factor alpha) plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. TNF-alpha was first identified as a cytotoxic factor produced by macrophages capable of killing mouse tumor cells.&nbsp;It is the prototypic ligand and along with Lymphotoxin-alpha, were identified as the first members of the TNF superfamily. Active TNF-alpha and other members of the TNF superfamily exist as a homotrimer with high structural homology. Receptor binding occurs at the interface of two TNF-alpha monomers. And receptor activation occurs when all three monomer interfaces are engaged with a receptor. For TNF-alpha, receptor binding and activation occurs through TNF R1 or TNF RII, and subsequently leads to activation of NF-kB or MAPK signaling pathways. Another pathway that TNF-alpha can activate utilizes the death domain of TNF RI to induce apoptosis. TNF-alpha promotes the inflammatory response largely through NF-kB signaling, and inhibition of TNF-alpha has proven successful in treating many autoimmune disorders. TNF-alpha is also present on the cell surface as membrane-bound TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells. TNF-alpha protein is translated as a type II transmembrane protein containing an N-terminal transmembrane domain. The soluble cytokine is released from its cell-anchoring TM domain by proteolytic processing by metalloproteases.</p>"> <div class="data-display"> <p>TNF-alpha (Tumor necrosis factor alpha) plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. TNF-alpha was first identified as a cytotoxic factor produced by macrophages capable of killing mouse tumor cells. It is the prototypic ligand and along with Lymphotoxin-alpha, were identified as the first members of the TNF superfamily. Active TNF-alpha and other members of the TNF superfamily exist as a homotrimer with high structural homology. Receptor binding occurs at the interface of two TNF-alpha monomers. And receptor activation occurs when all three monomer interfaces are engaged with a receptor. For TNF-alpha, receptor binding and activation occurs through TNF R1 or TNF RII, and subsequently leads to activation of NF-kB or MAPK signaling pathways. Another pathway that TNF-alpha can activate utilizes the death domain of TNF RI to induce apoptosis. TNF-alpha promotes the inflammatory response largely through NF-kB signaling, and inhibition of TNF-alpha has proven successful in treating many autoimmune disorders. TNF-alpha is also present on the cell surface as membrane-bound TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells. TNF-alpha protein is translated as a type II transmembrane protein containing an N-terminal transmembrane domain. The soluble cytokine is released from its cell-anchoring TM domain by proteolytic processing by metalloproteases.</p> </div> <a href="#" class="show-more-btn">Show More</a> </div> <p> <span class="search_num_results" data-search_results="5">5 results</span> for "<span class="search_term_text">TNF-alpha</span>" in <strong id="search_category">Products</strong> </p> </div> <div class="row"> <div class="col-12 col-sm-6 text-sm-right my-2"> <button id="sort-filter" class="border rounded btn w-100 text-left" type="button">Done</button> </div> </div> </div> <div class="row"> <div class="col-md-12 text-lg-right mb-2">  </div> </div> <div id="selected_search_categories" class="row mb-3 d-none d-xl-flex align-items-center"> <div class="col text-center search-category-logo" data-search-category-id="brg_dyn_qq3u5f5ecf"> <div class="icon-text" data-aos="fade-up" data-aos-delay="300"> <a class="hero-icon-group" href="#" data-filter="Antibodies"> <img class="hero-icon w-50" src="https://resources.bio-techne.com/bio-techne-assets/images/icons/Antibodies_Light.svg" alt="Antibodies Icon"/><br/> <span class="hero-icon-text text-center d-block">Antibodies</span> </a> </div> </div> <div class="col text-center search-category-logo" data-search-category-id="brg_dyn_4641d19eg9"> <div class="icon-text" data-aos="fade-up" data-aos-delay="300"> <a class="hero-icon-group" href="#" data-filter="Instruments & Consumables"> <img class="hero-icon w-50" src="https://resources.bio-techne.com/bio-techne-assets/images/icons/Instruments_Light.svg" alt="Instruments & Consumables Icon"/><br/> <span class="hero-icon-text text-center d-block">Instruments & Consumables</span> </a> </div> </div> <div class="col text-center search-category-logo" data-search-category-id="brg_dyn_pc0dyu495u"> <div class="icon-text" data-aos="fade-up" data-aos-delay="300"> <a class="hero-icon-group" href="#" data-filter="ELISAs & Immunoassays"> <img class="hero-icon w-50" src="https://resources.bio-techne.com/bio-techne-assets/images/icons/ELISAs_Light.svg" alt="ELISAs & Immunoassays Icon"/><br/> <span class="hero-icon-text text-center d-block">ELISAs & Immunoassays</span> </a> </div> </div> </div> <div id="search-facets-container" class="row mobile-filter-toggle"> <div id="search_facets" class="col-12 d-flex justify-content-left align-items-center"> <div class="mobile_facet_wrapper bg-white p-0 rounded m-0"> <div class="search_mobile_buttons position-relative"> <div class="search_toggle btn btn-tertiary">Back to Search Results</div> <div class="search_toggle btn btn-secondary right">Apply</div> </div> <div id="search_facets_block" class="d-flex flex-row flex-wrap"> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle horizontal-dropdown" type="button" id="dropdown-menu-button-category_attr" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Category </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-category_attr"> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&category_attr=Luminex Assays" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="Luminex Assays (2)" data-facet_lower="luminex assays" class="search_facet_name text-break category_attr"> Luminex Assays <span class="facet_count">(2)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&category_attr=Primary Antibodies" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="Primary Antibodies (2)" data-facet_lower="primary antibodies" class="search_facet_name text-break category_attr"> Primary Antibodies <span class="facet_count">(2)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&category_attr=ELISA Kits" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="ELISA Kits (1)" data-facet_lower="elisa kits" class="search_facet_name text-break category_attr"> ELISA Kits <span class="facet_count">(1)</span> </span> </a> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle horizontal-dropdown" type="button" id="dropdown-menu-button-sub_category" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Sub Category </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-sub_category"> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&sub_category=Luminex High Performance Assays" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="Luminex High Performance Assays (2)" data-facet_lower="luminex high performance assays" class="search_facet_name text-break sub_category"> Luminex High Performance Assays <span class="facet_count">(2)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&sub_category=DuoSet ELISA Development Systems" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="DuoSet ELISA Development Systems (1)" data-facet_lower="duoset elisa development systems" class="search_facet_name text-break sub_category"> DuoSet ELISA Development Systems <span class="facet_count">(1)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&sub_category=Monoclonal Antibodies" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="Monoclonal Antibodies (1)" data-facet_lower="monoclonal antibodies" class="search_facet_name text-break sub_category"> Monoclonal Antibodies <span class="facet_count">(1)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&sub_category=Polyclonal Antibodies" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="Polyclonal Antibodies (1)" data-facet_lower="polyclonal antibodies" class="search_facet_name text-break sub_category"> Polyclonal Antibodies <span class="facet_count">(1)</span> </span> </a> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle horizontal-dropdown" type="button" id="dropdown-menu-button-species" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Species </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-species"> <div class="facet search_facet_search_category facet_list p-1"> <input type="text" class="form-control w-100 my-2 facet_category_search species" data-facet_title="species" placeholder="Search Species..."/> </div> <div class="facets_wrapper"> <div class="m___radio-filter facet active"> <a href="/t/tnf-alpha?species=Cynomolgus" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Primate (5)" data-facet_lower="primate" class="search_facet_name text-break species"> Primate <span class="facet_count">(5)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Human" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Human (838)" data-facet_lower="human" class="search_facet_name text-break species"> Human <span class="facet_count">(838)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Mouse" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Mouse (207)" data-facet_lower="mouse" class="search_facet_name text-break species"> Mouse <span class="facet_count">(207)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Rat" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Rat (108)" data-facet_lower="rat" class="search_facet_name text-break species"> Rat <span class="facet_count">(108)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Porcine" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Porcine (12)" data-facet_lower="porcine" class="search_facet_name text-break species"> Porcine <span class="facet_count">(12)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Avian - Chicken" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Avian - Chicken (1)" data-facet_lower="avian - chicken" class="search_facet_name text-break species"> Avian - Chicken <span class="facet_count">(1)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Chicken" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Chicken (1)" data-facet_lower="chicken" class="search_facet_name text-break species"> Chicken <span class="facet_count">(1)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Fish" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Fish (55)" data-facet_lower="fish" class="search_facet_name text-break species"> Fish <span class="facet_count">(55)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Canine" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Canine (42)" data-facet_lower="canine" class="search_facet_name text-break species"> Canine <span class="facet_count">(42)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Rabbit" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Rabbit (36)" data-facet_lower="rabbit" class="search_facet_name text-break species"> Rabbit <span class="facet_count">(36)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Mouse (Negative)" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Mouse (Negative) (29)" data-facet_lower="mouse (negative)" class="search_facet_name text-break species"> Mouse (Negative) <span class="facet_count">(29)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Sheep" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Sheep (25)" data-facet_lower="sheep" class="search_facet_name text-break species"> Sheep <span class="facet_count">(25)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Feline" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Feline (11)" data-facet_lower="feline" class="search_facet_name text-break species"> Feline <span class="facet_count">(11)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Guinea Pig" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Guinea Pig (11)" data-facet_lower="guinea pig" class="search_facet_name text-break species"> Guinea Pig <span class="facet_count">(11)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Zebrafish" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Zebrafish (9)" data-facet_lower="zebrafish" class="search_facet_name text-break species"> Zebrafish <span class="facet_count">(9)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Rhesus Macaque" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Rhesus Macaque (8)" data-facet_lower="rhesus macaque" class="search_facet_name text-break species"> Rhesus Macaque <span class="facet_count">(8)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Monkey" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Monkey (7)" data-facet_lower="monkey" class="search_facet_name text-break species"> Monkey <span class="facet_count">(7)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Cotton Rat" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Cotton Rat (5)" data-facet_lower="cotton rat" class="search_facet_name text-break species"> Cotton Rat <span class="facet_count">(5)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Bovine" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Bovine (4)" data-facet_lower="bovine" class="search_facet_name text-break species"> Bovine <span class="facet_count">(4)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Equine" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Equine (3)" data-facet_lower="equine" class="search_facet_name text-break species"> Equine <span class="facet_count">(3)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Non-human Primate" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Non-human Primate (3)" data-facet_lower="non-human primate" class="search_facet_name text-break species"> Non-human Primate <span class="facet_count">(3)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Cynomolgus Monkey" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Cynomolgus Monkey (2)" data-facet_lower="cynomolgus monkey" class="search_facet_name text-break species"> Cynomolgus Monkey <span class="facet_count">(2)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Ferret" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Ferret (1)" data-facet_lower="ferret" class="search_facet_name text-break species"> Ferret <span class="facet_count">(1)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus|Primate - Macaca mulatta (Rhesus Macaque)" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Primate - Macaca mulatta (Rhesus Macaque) (1)" data-facet_lower="primate - macaca mulatta (rhesus macaque)" class="search_facet_name text-break species"> Primate - Macaca mulatta (Rhesus Macaque) <span class="facet_count">(1)</span> </span> </a> </div> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle horizontal-dropdown" type="button" id="dropdown-menu-button-applications" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Application </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-applications"> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&applications=ELISA" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="ELISA (4)" data-facet_lower="elisa" class="search_facet_name text-break applications"> ELISA <span class="facet_count">(4)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&applications=Immunocytochemistry/ Immunofluorescence" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Immunocytochemistry/ Immunofluorescence (2)" data-facet_lower="immunocytochemistry/ immunofluorescence" class="search_facet_name text-break applications"> Immunocytochemistry/ Immunofluorescence <span class="facet_count">(2)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&applications=Immunohistochemistry" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Immunohistochemistry (2)" data-facet_lower="immunohistochemistry" class="search_facet_name text-break applications"> Immunohistochemistry <span class="facet_count">(2)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&applications=Block/Neutralize" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Block/Neutralize (1)" data-facet_lower="block/neutralize" class="search_facet_name text-break applications"> Block/Neutralize <span class="facet_count">(1)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&applications=Flow Cytometry" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Flow Cytometry (1)" data-facet_lower="flow cytometry" class="search_facet_name text-break applications"> Flow Cytometry <span class="facet_count">(1)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&applications=Western Blot" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="Western Blot (1)" data-facet_lower="western blot" class="search_facet_name text-break applications"> Western Blot <span class="facet_count">(1)</span> </span> </a> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle horizontal-dropdown" type="button" id="dropdown-menu-button-conjugate_form" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Conjugates </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-conjugate_form"> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&conjugate_form=Unconjugated" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="Unconjugated (4)" data-facet_lower="unconjugated" class="search_facet_name text-break conjugate_form"> Unconjugated <span class="facet_count">(4)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&conjugate_form=Biotin" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="Biotin (1)" data-facet_lower="biotin" class="search_facet_name text-break conjugate_form"> Biotin <span class="facet_count">(1)</span> </span> </a> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle horizontal-dropdown" type="button" id="dropdown-menu-button-clonality" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Clonality </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-clonality"> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&clonality=Monoclonal" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="Monoclonal (1)" data-facet_lower="monoclonal" class="search_facet_name text-break clonality"> Monoclonal <span class="facet_count">(1)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&clonality=Polyclonal" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="Polyclonal (1)" data-facet_lower="polyclonal" class="search_facet_name text-break clonality"> Polyclonal <span class="facet_count">(1)</span> </span> </a> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle horizontal-dropdown" type="button" id="dropdown-menu-button-host" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Host Species </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-host"> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&host=Mouse" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="Mouse (1)" data-facet_lower="mouse" class="search_facet_name text-break host"> Mouse <span class="facet_count">(1)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&host=Rabbit" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="Rabbit (1)" data-facet_lower="rabbit" class="search_facet_name text-break host"> Rabbit <span class="facet_count">(1)</span> </span> </a> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle more-facet" type="button" id="dropdown-menu-button-isotype" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Isotype </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-isotype"> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&isotype=IgG1 kappa" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="IgG1 kappa (1)" data-facet_lower="igg1 kappa" class="search_facet_name text-break isotype"> IgG1 kappa <span class="facet_count">(1)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&isotype=Serum" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="Serum (1)" data-facet_lower="serum" class="search_facet_name text-break isotype"> Serum <span class="facet_count">(1)</span> </span> </a> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle more-facet" type="button" id="dropdown-menu-button-clone" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Clone </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-clone"> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&clone=MAb11" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="MAb11 (1)" data-facet_lower="mab11" class="search_facet_name text-break clone"> MAb11 <span class="facet_count">(1)</span> </span> </a> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle more-facet" type="button" id="dropdown-menu-button-low_endotoxin" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Low Endotoxin </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-low_endotoxin"> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&low_endotoxin=False" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="False (3)" data-facet_lower="false" class="search_facet_name text-break low_endotoxin"> No <span class="facet_count">(3)</span> </span> </a> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle more-facet" type="button" id="dropdown-menu-button-has_sample_size" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Sample Size </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-has_sample_size"> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&has_sample_size=False" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="False (4)" data-facet_lower="false" class="search_facet_name text-break has_sample_size"> No <span class="facet_count">(4)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&has_sample_size=True" rel="nofollow" class="facet_item"> <span class="styled_checkbox a___button-checkbox"> <span class="checkbox_square"></span> <span class="checkbox_square_inner"></span> </span> <span data-facet="True (1)" data-facet_lower="true" class="search_facet_name text-break has_sample_size"> Yes <span class="facet_count">(1)</span> </span> </a> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle more-facet" type="button" id="dropdown-menu-button-stars" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Reviews </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-stars"> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&stars=5.0" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="5.0 (2)" data-facet_lower="5.0" class="search_facet_name text-break stars"> <span class="searchImage_star5"></span> 5 (2) </span> </a> </div> </div> </div> </div> <div class="search_facet_category_block"> <div class="dropdown-container position-relative"> <button class="btn btn-secondary dropdown-toggle more-facet" type="button" id="dropdown-menu-button-brand" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false"> Brand </button> <div class="dropdown-menu" aria-labelledby="dropdown-menu-button-brand"> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&brand=rnd" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="rnd (3)" data-facet_lower="rnd" class="search_facet_name text-break brand"> R&D Systems <span class="facet_count">(3)</span> </span> </a> </div> <div class="m___radio-filter facet"> <a href="/t/tnf-alpha?species=Primate|Cynomolgus&brand=novus" rel="nofollow" class="facet_item"> <span class="styled_radio a___button-radio"> <span class="radio_circle"></span> <span class="radio_circle_inner"></span> </span> <span data-facet="novus (2)" data-facet_lower="novus" class="search_facet_name text-break brand"> Novus Biologicals <span class="facet_count">(2)</span> </span> </a> </div> </div> </div> </div> <div class="text-center mx-2 my-2"> <a href="#" id="show-more-less-facets" class="d-inline font-weight-bold h5">Show More</a> </div> </div> </div> </div> </div> <div class="row"> <div class="col-md-6 d-none d-lg-block"> <p> <span class="search_num_results" data-search_results="5">5 results</span> for "<span class="search_term_text">TNF-alpha</span>" in <strong id="search_category">Products</strong> </p> </div> <div class="col-md-6 text-lg-right"> <label for="sort_by_select">Sort by:</label> <select id="sort_by_select" class="sort_by_select rounded-0 p-0" aria-label="Sort by"> <option value="/t/tnf-alpha?species=Primate%7CCynomolgus&sort=ranking,desc" selected="selected" >Best Match </option> <option value="/t/tnf-alpha?species=Primate%7CCynomolgus&sort=title,asc" >Products (A-Z) </option> <option value="/t/tnf-alpha?species=Primate%7CCynomolgus&sort=product_created_date,desc" >Newest </option> <option value="/t/tnf-alpha?species=Primate%7CCynomolgus&sort=stars,desc" >Rating </option> </select> </div> </div> <div id="search_results" class="row mt-3" data-search_term="TNF-alpha"> <div class="col-lg-12"> <div class="d-none d-lg-block"> <p class="target_h1">TNF-alpha Products</p> <div class="show-more" data-text="<p>TNF-alpha (Tumor necrosis factor alpha) plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. TNF-alpha was first identified as a cytotoxic factor produced by macrophages capable of killing mouse tumor cells.&nbsp;It is the prototypic ligand and along with Lymphotoxin-alpha, were identified as the first members of the TNF superfamily. Active TNF-alpha and other members of the TNF superfamily exist as a homotrimer with high structural homology. Receptor binding occurs at the interface of two TNF-alpha monomers. And receptor activation occurs when all three monomer interfaces are engaged with a receptor. For TNF-alpha, receptor binding and activation occurs through TNF R1 or TNF RII, and subsequently leads to activation of NF-kB or MAPK signaling pathways. Another pathway that TNF-alpha can activate utilizes the death domain of TNF RI to induce apoptosis. TNF-alpha promotes the inflammatory response largely through NF-kB signaling, and inhibition of TNF-alpha has proven successful in treating many autoimmune disorders. TNF-alpha is also present on the cell surface as membrane-bound TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells. TNF-alpha protein is translated as a type II transmembrane protein containing an N-terminal transmembrane domain. The soluble cytokine is released from its cell-anchoring TM domain by proteolytic processing by metalloproteases.</p>"> <div class="data-display"> <p>TNF-alpha (Tumor necrosis factor alpha) plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. TNF-alpha was first identified as a cytotoxic factor produced by macrophages capable of killing mouse tumor cells. It is the prototypic ligand and along with Lymphotoxin-alpha, were identified as the first members of the TNF superfamily. Active TNF-alpha and other members of the TNF superfamily exist as a homotrimer with high structural homology. Receptor binding occurs at the interface of two TNF-alpha monomers. And receptor activation occurs when all three monomer interfaces are engaged with a receptor. For TNF-alpha, receptor binding and activation occurs through TNF R1 or TNF RII, and subsequently leads to activation of NF-kB or MAPK signaling pathways. Another pathway that TNF-alpha can activate utilizes the death domain of TNF RI to induce apoptosis. TNF-alpha promotes the inflammatory response largely through NF-kB signaling, and inhibition of TNF-alpha has proven successful in treating many autoimmune disorders. TNF-alpha is also present on the cell surface as membrane-bound TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells. TNF-alpha protein is translated as a type II transmembrane protein containing an N-terminal transmembrane domain. The soluble cytokine is released from its cell-anchoring TM domain by proteolytic processing by metalloproteases.</p> </div> <a href="#" class="show-more-btn">Show More</a> </div> </div> <div id="search_results_selected_facets" class="my-2"> <div id="search_results_selected_facet_legend" class="d-inline-block"> Filters: </div> <a class="search_results_selected_facet mx-1 py-1 px-2 clear_facet btn btn-default" href="/t/tnf-alpha?species=Cynomolgus" rel="nofollow"> Primate </a> <a href="/t/tnf-alpha" id="clear_filters">Clear All <strong>X</strong></a> </div> <div id="search_results_block"> <div class="search_result atc-container pb-3" data-brand="novus" data-category="Primary Antibodies" data-id="NB600-587" data-name="TNF-alpha Antibody - Azide Free" data-position="8"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/tnf-alpha-antibody_nb600-587" title="TNF-alpha Antibody - Azide Free"> <h4>TNF-alpha Antibody - Azide Free </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="Novus Biologicals, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-novus-biologicals.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/tnf-alpha-antibody_nb600-587" title="TNF-alpha Antibody - Azide Free"> NB600-587 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/tnf-alpha-antibody_nb600-587#reviews" class="searchImage_star5"> (1) </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/antibodies/tnf-alpha-antibody_nb600-587#citations"><span class="icon-icon-product-citations"></span>Citations (37)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/tnf-alpha-antibody_nb600-587#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (8)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> IHC, WB, ELISA, ICC/IF, B/N </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Human, Mouse, Rat, Primate, Chicken, +1 More </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-8" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-8"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Human, Mouse, Rat, Primate, Chicken, +1 More </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Rabbit Serum Polyclonal </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> IHC, WB, ELISA, ICC/IF, B/N </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="nb600-587"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="novus"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/TNF-alpha-Antibody---Azide-Free-Western-Blot-NB600-587-img0012.jpg data-srcset=https://resources.bio-techne.com/images/products/TNF-alpha-Antibody---Azide-Free-Western-Blot-NB600-587-img0012.jpg alt="Western Blot: TNF-alpha AntibodyAzide Free [NB600-587]" title="Western Blot: TNF-alpha AntibodyAzide Free [NB600-587]" data-caption="Western Blot: TNF-alpha Antibody - Azide Free [NB600-587] - Analysis using Azide/BSA FREE version of NB600-587. Membrane blocked in 1% BSA-TBS-T 30 min RT, 1:1000 dilution in 1% BSA-TBS-T 4C." data-badges="" data-application="Western Blot" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> <span class="image-count-text align-middle">(8)</span> </div> </div> </div> <i data-src="https://resources.bio-techne.com/images/products/TNF-alpha-Antibody---Azide-Free-Western-Blot-NB600-587-img0014.jpg" data-alt="Western Blot: TNF-alpha AntibodyAzide Free [NB600-587]" title="Western Blot: TNF-alpha AntibodyAzide Free [NB600-587]" data-caption="Western Blot: TNF-alpha Antibody - Azide Free [NB600-587] - Expression of TNF-alpha, IL-1beta and NF-kappaB in the brains of MCAO rats. Western blot confirmed that protein levels of TNF-alpha increased as early as 4 h after reperfusion, further increased at 24 h, peaked at 72 h and decreased at 7 days, respectively (*P" data-badges="" data-application="Western Blot" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/TNF-alpha-Antibody---Azide-Free-Immunocytochemistry-Immunofluorescence-NB600-587-img0015.jpg" data-alt="Immunocytochemistry/ Immunofluorescence: TNF-alpha Antibody - Azide Free [NB600-587]" title="Immunocytochemistry/ Immunofluorescence: TNF-alpha Antibody - Azide Free [NB600-587]" data-caption="Immunocytochemistry/Immunofluorescence: TNF-alpha Antibody - Azide Free [NB600-587] - LMP2 knockdown by shRNA reduced the expression of TNF-alpha and IL-1beta after MCAO. Immunofluorescence labeling revealed that both TNF-alpha and IL-1beta immunoreactivity was significantly upregulated in the ipsilateral ischemic hemisphere compared with sham-operated animals. In contrast, LMP2 knockdown by shRNA significantly reduced the expression of TNF-alpha and IL-1beta. Five rats in each group were used for immunofluorescent assays (n=5). Image collected and cropped by CiteAb from the following publication (https://www.nature.com/articles/cddis2014586), licensed under a CC-BY license." data-badges="<span class="knockout-validation"></span>" data-application="Immunocytochemistry/ Immunofluorescence" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/TNF-alpha-Antibody---Azide-Free-Immunohistochemistry-NB600-587-img0008.jpg" data-alt="Immunohistochemistry: TNF-alpha Antibody - Azide Free [NB600-587]" title="Immunohistochemistry: TNF-alpha Antibody - Azide Free [NB600-587]" data-caption="Immunohistochemistry: TNF-alpha Antibody - Azide Free [NB600-587] - Staining of formalin/PFA-fixed paraffin-embedded sections of human artery tissue sections. Sections were fixed in formaldehyde and subjected to heat mediated antigen retrieval in citrate buffer (pH 6.0). Slides were blocked for ten minutes with 1.5% serum. Primary antibody was diluted 1:100 and incubated with samples for 24 hours at 4C. HRP-conjugated goat anti-rabbit antibody was used as the secondary antibody." data-badges="" data-application="Immunohistochemistry" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/TNF-alpha-Antibody---Azide-Free-Western-Blot-NB600-587-img0013.jpg" data-alt="Western Blot: TNF-alpha AntibodyAzide Free [NB600-587]" title="Western Blot: TNF-alpha AntibodyAzide Free [NB600-587]" data-caption="Western Blot: TNF-alpha Antibody - Azide Free [NB600-587] - Expression of TNF-alpha, IL-1beta and NF-kappaB in the brains of MCAO rats. Western blot confirmed that protein levels of TNF-alpha increased as early as 4 h after reperfusion, further increased at 24 h, peaked at 72 h and decreased at 7 days, respectively (*P" data-badges="" data-application="Western Blot" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/nb600-587_rabbit-polyclonal-tnf-alpha-antibody-azide-free-23520231814584.jpg" data-alt="TNF-alpha Antibody - Azide Free" title="TNF-alpha Antibody - Azide Free" data-caption="Fluorescent immunohistochemistry showing staining of human colon by anti-TNF alpha (formalin/PFA-fixed paraffin-embedded sections). Samples were formaldehyde-fixed, then blocked in 10% serum for 2 hours at 20C. The primary antibody was diluted 1:100 and incubated with the sample for 2 hours at 20C. Alexa Fluor(R) 680 goat polyclonal secondary antibody was used diluted 1:5000." data-badges="" data-application="Immunohistochemistry" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/nb600-587_rabbit-polyclonal-tnf-alpha-antibody-azide-free-23520231814315.jpg" data-alt="TNF-alpha Antibody - Azide Free" title="TNF-alpha Antibody - Azide Free" data-caption="Immunohistochemistry using polyclonal TNFa antibody showing staining of formalin/PFA-fixed paraffin-embedded sections of human artery tissue sections. Sections were fixed in formaldehyde and subjected to heat mediated antigen retrieval in citrate buffer (pH 6.0). Slides were blocked for ten minutes with 1.5% serum. Primary antibody was diluted 1:100 and incubated with samples for 24 hours at 4C. HRP-conjugated goat anti-rabbit antibody was used as the secondary antibody." data-badges="" data-application="Immunohistochemistry" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/nb600-587_rabbit-polyclonal-tnf-alpha-antibody-azide-free-24520231056461.jpg" data-alt="TNF-alpha Antibody - Azide Free" title="TNF-alpha Antibody - Azide Free" data-caption="Western blot of TNF-alpha Antibody - Azide Free. Lane 1: 250ng human recombinant TNF. Lane 2: 500ng human recombinant TNF. Lane 3: 1000ng human recombinant TNF. Membrane blocked in Blotto" data-badges="" data-application="Western Blot" data-width="250" data-height="250" class="none"></i> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-NB600-587" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="NB600-587"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-NB600-587" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="NB600-587"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> NB600-587 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="NB600-587SS"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> NB600-587SS </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-NB600-587-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=NB600-587" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Luminex Assays" data-id="FCSTM21" data-name="NHP XL Cytokine Luminex® Performance Premixed Kit" data-position="6"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/luminex-assays/nhp-xl-cytokine-luminex-performance-premixed-kit_fcstm21" title="NHP XL Cytokine Luminex® Performance Premixed Kit"> <h4>NHP XL Cytokine Luminex® Performance Premixed Kit <span class="rounded align-middle p-1 badge best-seller" title="Best Seller">Best Seller</span> </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/luminex-assays/nhp-xl-cytokine-luminex-performance-premixed-kit_fcstm21" title="NHP XL Cytokine Luminex® Performance Premixed Kit"> FCSTM21 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/luminex-assays/nhp-xl-cytokine-luminex-performance-premixed-kit_fcstm21#reviews" class="searchImage_star5"> (3) </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/luminex-assays/nhp-xl-cytokine-luminex-performance-premixed-kit_fcstm21#citations"><span class="icon-icon-product-citations"></span>Citations (9)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/luminex-assays/nhp-xl-cytokine-luminex-performance-premixed-kit_fcstm21#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (2)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> ELISA </div> <div class="d-none d-md-block"> </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-6" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-6"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <p>Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.</p> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> ELISA </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="fcstm21"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/fcstm21_non-human-primate-xl-disc-premixed-luminex-perf-assay-kit-189202085348.png data-srcset=https://resources.bio-techne.com/images/products/fcstm21_non-human-primate-xl-disc-premixed-luminex-perf-assay-kit-189202085348.png alt="NHP Luminex Standard Curves (Cell Culture Supernates)" title="NHP Luminex Standard Curves (Cell Culture Supernates)" data-caption="" data-badges="" data-application="Multiplex Immunoassay" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> <span class="image-count-text align-middle">(2)</span> </div> </div> </div> <i data-src="https://resources.bio-techne.com/images/products/fcstm21_non-human-primate-xl-disc-premixed-luminex-perf-assay-kit-2872020163247.jpg" data-alt="NHP Luminex XL Cytokine Luminex Performance Premixed Kit" title="NHP Luminex XL Cytokine Luminex Performance Premixed Kit" data-caption="" data-badges="" data-application="Multiplex Immunoassay" data-width="250" data-height="250" class="none"></i> </div> </div> </div> </div> <div class="mt-2 text-right"> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="ELISA Kits" data-id="DY1070" data-name="Primate TNF-alpha DuoSet ELISA" data-position="2"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/elisa-kits/primate-tnf-alpha-duoset-elisa_dy1070" title="Primate TNF-alpha DuoSet ELISA"> <h4>Primate TNF-alpha DuoSet ELISA </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/elisa-kits/primate-tnf-alpha-duoset-elisa_dy1070" title="Primate TNF-alpha DuoSet ELISA"> DY1070 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold"> <a href="/p/elisa-kits/primate-tnf-alpha-duoset-elisa_dy1070#citations"><span class="icon-icon-product-citations"></span>Citations (3)</a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/elisa-kits/primate-tnf-alpha-duoset-elisa_dy1070#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (1)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> ELISA </div> <div class="d-none d-md-block"> </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-2" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-2"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Assay Range:</strong></td> <td class="pb-1 w-75 text-break"> 31.2 - 2,000 pg/mL </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> ELISA </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="dy1070"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.bio-techne.com/images/products/elisa/DATA_TNFalpha_DY1070_ELISA_1564.jpg data-srcset=https://resources.bio-techne.com/images/products/elisa/DATA_TNFalpha_DY1070_ELISA_1564.jpg alt="Primate TNF-alpha ELISA Standard Curve" title="Primate TNF-alpha ELISA Standard Curve" data-caption="" data-badges="" data-application="N/A" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-DY1070" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="DY1070"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-DY1070" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="DY1070"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> DY1070 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-DY1070-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=DY1070" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="rnd" data-category="Luminex Assays" data-id="LNHPXL10702" data-name="NHP XL TNF-alpha, Magnetic Luminex® Performance Assay" data-position="3"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/luminex-assays/nhp-xl-tnf-alpha-magnetic-luminex-performance-assay_lnhpxl10702" title="NHP XL TNF-alpha, Magnetic Luminex® Performance Assay"> <h4>NHP XL TNF-alpha, Magnetic Luminex® Performance Assay </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="R&D Systems, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/luminex-assays/nhp-xl-tnf-alpha-magnetic-luminex-performance-assay_lnhpxl10702" title="NHP XL TNF-alpha, Magnetic Luminex® Performance Assay"> LNHPXL10702 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/luminex-assays/nhp-xl-tnf-alpha-magnetic-luminex-performance-assay_lnhpxl10702#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> </div> <div class="d-none d-md-block"> </div> <div class="d-none d-md-block"> </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-3" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-3"> <div class="row"> <div class="search_result_description col-xs-12 col-sm-12"> <p>Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.</p> </div> </div> <div class="row"> <div class="search_result_product_details col-xs-12 col-sm-9"> <div class="compare_tool_select form-inline mb-2" data-sku="lnhpxl10702"></div> </div> </div> <div class="mt-2 text-right"> </div> </div> </div> </div> <div class="search_result atc-container pb-3" data-brand="novus" data-category="Primary Antibodies" data-id="NBP3-09105" data-name="TNF-alpha Antibody (MAb11) - BSA Free" data-position="14"> <div class="search_details border bg-white p-3 rounded"> <div class="row"> <div class="col-md-9"> <a href="/p/antibodies/tnf-alpha-antibody-mab11_nbp3-09105" title="TNF-alpha Antibody (MAb11) - BSA Free"> <h4>TNF-alpha Antibody (MAb11) - BSA Free </h4> </a> </div> <div class="search_result_brand_logo col-md-3 mb-1 d-flex justify-content-xl-end product-brand-logo"> <img alt="Novus Biologicals, a Bio-Techne brand" src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-novus-biologicals.svg" class="d-flex w-75"> </div> </div> <div class="row"> <div class="col-md-9"> <div class="mb-1 d-inline-flex"> <div class="align-middle my-1 mr-3 d-block d-md-inline"> Catalog #: <a href="/p/antibodies/tnf-alpha-antibody-mab11_nbp3-09105" title="TNF-alpha Antibody (MAb11) - BSA Free"> NBP3-09105 </a> </div> <div class="align-middle my-1 mr-3 d-block d-md-inline font-weight-bold text-nowrap"> <a href="/p/antibodies/tnf-alpha-antibody-mab11_nbp3-09105#product-documents"><span class="icon-icon-pdf text-error-red"></span> Product Documents</a> </div> <div class="d-none d-md-inline my-1"> <a href="#" class="search_result_images"><span class="icon-icon-image-camera-plus"></span> Images (1)</a> </div> </div> <div class="d-none d-md-block"> <span class="search_result_applications"></span><span class="applications_title"><strong>Applications:</strong></span> IHC, ELISA, ICC/IF, Flow </div> <div class="d-none d-md-block"> <span class="species_title"><strong>Reactivity:</strong></span> Human, Primate, Porcine </div> </div> <div class="col-md-3"> <button class="py-1 btn-default btn-block atc-view-more collapsed" data-toggle="collapse" href="#collapseButton-14" role="button" aria-expanded="false" aria-controls="collapseButton">View More</button> </div> </div> <div class="commerce-atc-search pt-3 collapse" id="collapseButton-14"> <div class="row"> <div class="search_result_description col-xs-12 col-md-9"> <table class="tablesaw tablesaw-stack mb-2"> <tbody> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Reactivity:</strong></td> <td class="pb-1 w-75 text-break"> Human, Primate, Porcine </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Details:</strong></td> <td class="pb-1 w-75 text-break"> Mouse IgG1 kappa Monoclonal Clone #MAb11 </td> </tr> <tr class="search_result_product_detail"> <td class="pb-1 align-top text-md-right"><strong>Applications:</strong></td> <td class="pb-1 w-75 text-break"> IHC, ELISA, ICC/IF, Flow </td> </tr> </tbody> </table> <div class="compare_tool_select form-inline mb-2" data-sku="nbp3-09105"></div> </div> <div class="search_result_image_wrapper col-xs-12 col-md-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="novus"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src=https://resources.rndsystems.com/categoryimages/novus_antibodies.jpg data-srcset=https://resources.rndsystems.com/categoryimages/novus_antibodies.jpg alt="Novus Antibodies" title="Novus Antibodies" data-caption="" data-badges="" data-application="" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> </div> <div class="atc-block-search atc-block-collapsible" data-type="search" data-blockid="ProductCart-NBP3-09105" > <form action="/commerce/addtocart" method="post" class="px-3 pt-3 add-to-cart-block" data-productcode="NBP3-09105"> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-4 font-weight-bold">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-3 font-weight-bold d-none d-md-block">Availability </div> <div class="commerce-atc-price atc-head col-5 col-md-3 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-3 col-md-2 text-right font-weight-bold">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart-NBP3-09105" class="atc-lines"> <div class="commerce-atc-search-productline productline col-four row py-2 m-0" data-catalog="NBP3-09105"> <div class="commerce-atc-catnum col-4 col-md-4 my-2"> NBP3-09105 </div> <div class="commerce-atc-availability col-md-3 my-2 d-none d-md-block"> </div> <div class="commerce-atc-price col-5 col-md-3 my-2"> </div> <div class="commerce-atc-quantity col-3 col-md-2 my-2 text-right"> </div> </div> <hr class="d-md-none bg-light"> </div> <div class="atc-control ProductCart-NBP3-09105-control text-right"> <div class="row d-flex justify-content-end mx-0 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=NBP3-09105" class="atc-bulk-button btn a___button-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </div> </div> </div> <div id="search_results_bottom" class="row py-2 mb-5"> <div id="search_results_per_page" class="col-lg-9 col-sm-8 col-8"> <div class="d-inline-flex pt-1"> <div id="search_results_per_page_legend">Results Per Page</div> <a class="search_results_per_page_link px-2" rel="nofollow" href="/t/tnf-alpha?species=Primate%7CCynomolgus&page=1&num_results=5">5</a> <a class="search_results_per_page_link px-2" rel="nofollow" href="/t/tnf-alpha?species=Primate%7CCynomolgus&page=1&num_results=10">10</a> <span class="search_results_per_page_selected px-2">25</span> <a class="search_results_per_page_link px-2" rel="nofollow" href="/t/tnf-alpha?species=Primate%7CCynomolgus&page=1&num_results=50">50</a> </div> </div> <div id="search_pager_block" class="col-lg-3 col-sm-4 col-4 text-right w-100"> <div id="search_pager"> <div class="searchImage_backGrey"></div> <input type="number" min="1" max="1" value="1" id="search_pager_text" class="d-inline-block border rounded" data-url="/t/tnf-alpha?species=Primate%7CCynomolgus&page=" aria-label="Page"/> / <span class="search_total_pages">1</span> <div class="searchImage_forwardGrey"></div> </div> </div> </div> </div> </div> </div> </div> </div> </section> </main> </div> </div> </div> <div id="brandsbar-footer" class="bg-bt-primary"> <div class="container-wide container-fluid text-white"> <div class="row py-5"> <div class="footer-logo col-xl-3 col-lg-auto d-flex"> <img class="brand-bar-footer-logo" src="/themes/custom/bio_techne_global/logo.svg" alt="Bio-techne logo"> </div> <div class="col-xl-9 col-lg-auto"> <p class="ml-xl-4 bt-px_groteskbold footer-tagline">Global Developer, Manufacturer, and Supplier of High-Quality Reagents, Analytical Instruments, and Precision Diagnostics.</p> </div> <div class="included-brands col"> <span class="font-weight-bold mr-3 bt-inter_regular">INCLUDES</span> <span class="mr-3 bt-inter_regular">R&D Systems™</span> <span class="mr-3 bt-inter_regular">Novus Biologicals™</span> <span class="mr-3 bt-inter_regular">Tocris Bioscience™</span> <span class="mr-3 bt-inter_regular">ProteinSimple™</span> <span class="mr-3 bt-inter_regular">ACD™</span> <span class="mr-3 bt-inter_regular">ExosomeDx™</span> <span class="mr-3 bt-inter_regular">Asuragen™</span> <span class="mr-3 bt-inter_regular">Lunaphore™</span> </div> </div> </div> </div> <div id="site-footer__top" class=" pt-4"> <div class="container-wide container-fluid pt-3"> <div> <div class="col-md-12"> <footer> <div> <div class="row"> <div class="col-xl-3 col-md-6 col-xs-12 p-0 text-white bt-inter_regular"> <div> <div id="block-footercolumn1" class="block_content:8da4adc8-094f-4085-8706-613703de4da6"> <div><h4>CONTACT INFORMATION</h4> <p>614 McKinley Place NE<br /> Minneapolis, MN 55413<br /> USA</p> <p>TEL <a href="tel:612 379 2956">612 379 2956</a><br /> Toll-free <a href="tel:800 343 7475">800 343 7475</a><br /> FAX 612 656 4400</p> </div> </div> </div> </div> <div class="col-xl-3 col-md-6 col-xs-12 p-0 bt-inter_regular"> <div> <nav role="navigation" aria-labelledby="block-footercolumn2-menu" id="block-footercolumn2"> <h4 id="block-footercolumn2-menu">Who We Are</h4> <ul> <li> <a href="/about/about-bio-techne" title="About Bio-Techne" data-drupal-link-system-path="node/16">About Bio-Techne</a> </li> <li> <a href="/brands" title="Brands" data-drupal-link-system-path="node/46">Bio-Techne Brands</a> </li> <li> <a href="/about/careers" title="History" data-drupal-link-system-path="node/21">Careers </a> </li> <li> <a href="/about/corporate-and-social-responsibility" title="Corporate Responsibility" data-drupal-link-system-path="node/61">Corporate & Social Responsibility </a> </li> <li> <a href="/terms-and-conditions" data-drupal-link-system-path="node/686">Terms and Conditions</a> </li> </ul> </nav> </div> </div> <div class="col-xl-3 col-md-6 col-xs-12 p-0 bt-inter_regular"> <div> <nav role="navigation" aria-labelledby="block-footercolumn3-menu" id="block-footercolumn3"> <h4 id="block-footercolumn3-menu">Investor Relations</h4> <ul> <li> <a href="https://investors.bio-techne.com/">Overview</a> </li> <li> <a href="https://investors.bio-techne.com/news-events">News / Events</a> </li> <li> <a href="https://investors.bio-techne.com/company-information">Company Information</a> </li> <li> <a href="https://investors.bio-techne.com/financial-information">Financial Information</a> </li> <li> <a href="https://investors.bio-techne.com/stock-data">Stock Data</a> </li> <li> <a href="https://investors.bio-techne.com/sec-filings">SEC Filings</a> </li> <li> <a href="https://investors.bio-techne.com/corporate-governance">Corporate Governance</a> </li> </ul> </nav> </div> </div> <div class="col-xl-3 col-md-6 col-xs-12 p-0 text-white bt-inter_regular"> <div> <div id="block-stayconnectedblock" class="block_content:3f9f347f-6b53-40fd-8dfa-25f57854770b"> <div><h4>Stay Connected</h4> <section class="social-icons mb-3"> <a href="https://www.linkedin.com/company/bio-techne" class="text-white mr-2" aria-label="Follow Bio-techne on LinkedIn"><span class="icon-linkedin rounded-pill p-3"></span></a> <a href="https://www.instagram.com/bio_techne/" class="text-white mr-2" aria-label="Follow Bio-techne on Instagram"><span class="icon-instagram rounded-pill p-3"></span></a> <a href="https://twitter.com/biotechne" class="text-white mr-2" aria-label="Follow Bio-techne on X"><span class="icon-x rounded-pill p-3"></span></a> <a href="https://www.youtube.com/channel/UCCE68f793S1eyQM2E1BH0Bw?reload=9" class="text-white mr-2" aria-label="Bio-techne YouTube channel"><span class="icon-youtube rounded-pill p-3"></span></a> <a href="https://www.facebook.com/BioTechne/" class="text-white" aria-label="Follow Bio-techne on Facebook"><span class="icon-facebook rounded-pill p-3"></span></a> </section></div> </div> </div> <div> <a href="/support/contact-us" class="py-2 mt-3 mb-4 text-center font-weight-bold text-decoration-none text-white">Contact Us </a> </div> </div> </div> </div> </footer> </div> <hr> <div class="pb-5 mt-4 d-flex flex-wrap legal-navigation"> <div class="mb-2"> <a href="https://www.bio-techne.com/privacy-and-cookie-policy" class="mr-4 text-white text-center">Privacy and Cookie Policy</a> </div> <div class="mb-2"> <a href="/sitemap" class="mr-4 text-white">Site Map</a> </div> <div class="text-white">© Copyright 2024 Bio-Techne. All Rights Reserved.</div> </div> </div> </div> </div> </div> <div> <div id="block-cookieblock" class="cookie_block"> <div class="cookie-notification-block" data-expires="100"> <div class="container"> <div class="row pt-4 pb-4 pl-5 pr-5"> <div class="col-lg-10 mb-1"> Bio-Techne uses cookies to provide you with a great website experience. By continuing to use this website you acknowledge this and agree to our cookie policy. <a class="cookie-notification-block__link text-white" href="/privacy-and-cookie-policy">Learn more</a>. </div> <div class="col-lg-2 text-lg-right text-center align-middle"> <a href="#" class="btn btn-primary text-nowrap js-cookies"> I Agree </a> </div> </div> </div> </div> </div> </div> </div> <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true" style="display: none;"> <div class="embeddedServiceInvitationHeader" aria-labelledby="snapins_titletext" aria-describedby="snapins_bodytext"> <img id="embeddedServiceAvatar"/> <span class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button type="button" id="closeInvite" class="embeddedServiceCloseIcon" aria-label="Exit invitation">×</button> </div> <div class="embeddedServiceInvitationBody"> <p id="snapins_bodytext">How can we help you?</p> </div> <div class="embeddedServiceInvitationFooter" aria-describedby="snapins_bodytext"> <button type="button" class="embeddedServiceActionButton" id="rejectInvite">Close</button> <button type="button" class="embeddedServiceActionButton" id="acceptInvite">Start Chat</button> </div> </div> <script>window.dataLayer = window.dataLayer || []; window.dataLayer.push({"drupalLanguage":"en","drupalCountry":"US","siteName":"Bio-Techne","brand":"R\u0026D","userUid":0});</script> <script src="/sites/default/files/js/js_mVdJA4ZLapieLfV1B3y5WMapm0UWgRaZG7aWi_fiUAc.js?scope=footer&delta=0&language=en&theme=bio_techne_global&include=eJyVUu1yxCAIfCGpj-SgocaekQySa9OnL0kumevHn_5CFmdZFmJhpTQ2CrXcKWCmpj6eIGwg7KA9o6CsbkDFiiuJjzTivbB0RxW7lhRm1DEsnSRgSrw07f7xACFdpMFsZEbVbs6ahEfrXDli9ZFZuwrOIQ3tj_oRoOtqBNll5lwpKGafdfqeYv6Zv-AbfriogdqILdEQKPE0kSTyUeFE4UKhF6X3MhDQ3ebv7vp-_TgEWYFvhUJjLa8loRZu_sDgGYNYOd3cLDwsSUMnlDT6IwShvlRrEit-rn7Yw__U7jzw4Dk0_yH53KIBM4rZw1z9cxKy7ZCE5BK6VbltFvgHBGWyNZpW5kkITf5cPqj66zRgXvr4RPF91ojiSlOStvuCtXyeptmlyGqzVLIuu18wV0w0ch2M7_dNbD5BZRzcfnalvbJMB9sGwBNwHs4XCH4oTw"></script> <script src="//resources.bio-techne.com/bio-techne-assets/css/bootstrap/js/bootstrap.bundle.min.js"></script> <script src="/sites/default/files/js/js_hk3w4Ahrg0WuSpyjSfn4hT0I53u2mDEFE7s_JmPDVQ4.js?scope=footer&delta=2&language=en&theme=bio_techne_global&include=eJyVUu1yxCAIfCGpj-SgocaekQySa9OnL0kumevHn_5CFmdZFmJhpTQ2CrXcKWCmpj6eIGwg7KA9o6CsbkDFiiuJjzTivbB0RxW7lhRm1DEsnSRgSrw07f7xACFdpMFsZEbVbs6ahEfrXDli9ZFZuwrOIQ3tj_oRoOtqBNll5lwpKGafdfqeYv6Zv-AbfriogdqILdEQKPE0kSTyUeFE4UKhF6X3MhDQ3ebv7vp-_TgEWYFvhUJjLa8loRZu_sDgGYNYOd3cLDwsSUMnlDT6IwShvlRrEit-rn7Yw__U7jzw4Dk0_yH53KIBM4rZw1z9cxKy7ZCE5BK6VbltFvgHBGWyNZpW5kkITf5cPqj66zRgXvr4RPF91ojiSlOStvuCtXyeptmlyGqzVLIuu18wV0w0ch2M7_dNbD5BZRzcfnalvbJMB9sGwBNwHs4XCH4oTw"></script> </body> </html>

CINXE.COM

TNF-alpha Products