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Friday, February 21, 2025</div><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD" href="/articles/716554-bioworld-by-clarivate-releases-comprehensive-2024-year-in-review">Breaking News: BioWorld by Clarivate releases comprehensive 2024 year in review</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_MEDTECH" href="/articles/717493-five-med-tech-trends-to-watch-in-2025">Breaking News: Five med-tech trends to watch in 2025</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_ASIA" href="/articles/716554-bioworld-by-clarivate-releases-comprehensive-2024-year-in-review">Breaking News: BioWorld by Clarivate releases comprehensive 2024 year in review</a></section><div id="section-2" class="main-body"> <script src="/javascripts/pages/article.js?v=1740151851"></script> <div id="breadcrumbs" class="breadcrumbs"><a class="" href="/">Home</a> » <a class="" href="/topics">Topics</a> » BioWorld Asia, Clinical</div> <div class="box1 article-topic"> <div class="records"> <h1 class="page-title"> BioWorld Asia, Clinical <div class="rss"> <a href="/rss/topic/86-bioworld-asia"> <img alt="BioWorld Asia, Clinical RSS Feed" height="16" width="16" loading="lazy" src="/images/icons/rss.gif" /> RSS </a> </div> </h1> <article class="record article-summary "> <div class="image"><a title="Kura/Kyowa Kirin’s ziftomenib hits phase II endpoints in AML" class="url" rel="" target="" href="https://www.bioworld.com/articles/717283-kura-kyowa-kirins-ziftomenib-hits-phase-ii-endpoints-in-aml"><img width="650" height="488" alt="3D illustration of acute myeloid leukemia cells" title="3D illustration of acute myeloid leukemia cells" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/AML-Acute-Myekoid-Leukemia-Cells.jpg?height=488&t=1718812728&width=650" /></a></div> <div class="article-summary__details has-image"> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/717283-kura-kyowa-kirins-ziftomenib-hits-phase-ii-endpoints-in-aml">Kura/Kyowa Kirin’s ziftomenib hits phase II endpoints in AML</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 11, 2025</div> <div class="author article-summary__author">By <a href="/authors/49-tamra-sami">Tamra Sami</a></div> <div class="comment-count article-summary__comment-count"><a title="Kura/Kyowa Kirin’s ziftomenib hits phase II endpoints in AML" class="more" href="https://www.bioworld.com/articles/717283-kura-kyowa-kirins-ziftomenib-hits-phase-ii-endpoints-in-aml#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Kura Oncology Inc. and Kyowa Kirin Co. Ltd.’s selective oral menin inhibitor, ziftomenib, met the primary endpoints in the phase II registrational Komet-001 trial in patients with relapsed/refractory NPM1-mutant acute myeloid leukemia (AML), and Kura expects to submit its NDA to the U.S. FDA in the second quarter of 2025.<br /></div><a title="Kura/Kyowa Kirin’s ziftomenib hits phase II endpoints in AML" class="more" href="https://www.bioworld.com/articles/717283-kura-kyowa-kirins-ziftomenib-hits-phase-ii-endpoints-in-aml">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="Alterity’s ATH-434 looks to be disease modifying in multiple system atrophy" class="url" rel="" target="" href="https://www.bioworld.com/articles/716991-alteritys-ath-434-looks-to-be-disease-modifying-in-multiple-system-atrophy"><img width="650" height="488" alt="Central nervous system" title="Central nervous system" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/CNS-illustration.png?height=488&t=1602704861&width=650" /></a></div> <div class="article-summary__details has-image"> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/716991-alteritys-ath-434-looks-to-be-disease-modifying-in-multiple-system-atrophy">Alterity’s ATH-434 looks to be disease modifying in multiple system atrophy</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 4, 2025</div> <div class="author article-summary__author">By <a href="/authors/49-tamra-sami">Tamra Sami</a></div> <div class="comment-count article-summary__comment-count"><a title="Alterity’s ATH-434 looks to be disease modifying in multiple system atrophy" class="more" href="https://www.bioworld.com/articles/716991-alteritys-ath-434-looks-to-be-disease-modifying-in-multiple-system-atrophy#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Alterity Therapeutics Ltd. reported positive top-line phase II results for lead candidate ATH-434 for treating multiple system atrophy, a rare neurological disorder similar to Parkinson's disease.<br /></div><a title="Alterity’s ATH-434 looks to be disease modifying in multiple system atrophy" class="more" href="https://www.bioworld.com/articles/716991-alteritys-ath-434-looks-to-be-disease-modifying-in-multiple-system-atrophy">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="Aussie spinout could change blood pressure paradigm with low-dose poly pill" class="url" rel="" target="" href="https://www.bioworld.com/articles/716988-aussie-spinout-could-change-blood-pressure-paradigm-with-low-dose-poly-pill"><img width="650" height="488" alt="Hand holding white pill" title="Hand holding white pill" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Drugs/Hand-holding-white-pill.jpg?height=488&t=1737662211&width=650" /></a></div> <div class="article-summary__details has-image"> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/716988-aussie-spinout-could-change-blood-pressure-paradigm-with-low-dose-poly-pill">Aussie spinout could change blood pressure paradigm with low-dose poly pill</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 4, 2025</div> <div class="author article-summary__author">By <a href="/authors/49-tamra-sami">Tamra Sami</a></div> <div class="comment-count article-summary__comment-count"><a title="Aussie spinout could change blood pressure paradigm with low-dose poly pill" class="more" href="https://www.bioworld.com/articles/716988-aussie-spinout-could-change-blood-pressure-paradigm-with-low-dose-poly-pill#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">George Medicines, a new spinout from Australia’s George Institute for Global Health, could offer patients better control of their blood pressure as well as fewer side effects thanks to an ultra-low-dose triple combination.<br /></div><a title="Aussie spinout could change blood pressure paradigm with low-dose poly pill" class="more" href="https://www.bioworld.com/articles/716988-aussie-spinout-could-change-blood-pressure-paradigm-with-low-dose-poly-pill">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="‘Exciting data’: S.Biomedics preps US IND of PD cell therapy" class="url" rel="" target="" href="https://www.bioworld.com/articles/716989-exciting-data-sbiomedics-preps-us-ind-of-pd-cell-therapy"><img width="650" height="488" alt="Stem cells" title="Stem cells" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Stem-cells1.png?height=488&t=1631914594&width=650" /></a></div> <div class="article-summary__details has-image"> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/716989-exciting-data-sbiomedics-preps-us-ind-of-pd-cell-therapy">‘Exciting data’: S.Biomedics preps US IND of PD cell therapy</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 4, 2025</div> <div class="author article-summary__author">By <a href="/authors/603-marian-yoonjee-chu">Marian (YoonJee) Chu</a></div> <div class="comment-count article-summary__comment-count"><a title="‘Exciting data’: S.Biomedics preps US IND of PD cell therapy" class="more" href="https://www.bioworld.com/articles/716989-exciting-data-sbiomedics-preps-us-ind-of-pd-cell-therapy#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">To realize the promise of cell therapy for neurodegenerative disorders, S.Biomedics Co. Ltd. is looking to expand clinical trials of TED-A9, its stem cell therapy for Parkinson’s disease (PD), to the U.S., having reaped positive results from a domestic phase I/IIa trial in November 2024.<br /></div><a title="‘Exciting data’: S.Biomedics preps US IND of PD cell therapy" class="more" href="https://www.bioworld.com/articles/716989-exciting-data-sbiomedics-preps-us-ind-of-pd-cell-therapy">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/716558-us-hhs-awards-shionogi-375m-to-develop-covid-19-prep-therapy">US HHS awards Shionogi $375M to develop COVID-19 PrEP therapy</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Jan. 21, 2025</div> <div class="author article-summary__author">By <a href="/authors/603-marian-yoonjee-chu">Marian (YoonJee) Chu</a></div> <div class="comment-count article-summary__comment-count"><a title="US HHS awards Shionogi $375M to develop COVID-19 PrEP therapy" class="more" href="https://www.bioworld.com/articles/716558-us-hhs-awards-shionogi-375m-to-develop-covid-19-prep-therapy#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Shionogi & Co. Ltd. won a $375 million project agreement from the Rapid Response Partnership Vehicle to develop its 3CL protease inhibitor, S-892216, as a long-acting injectable for COVID-19 pre-exposure prophylaxis. The project was awarded to New Jersey-based Shionogi Inc., a subsidiary of the Osaka, Japan-based pharmaceutical company. S-892216 is an investigational second-generation 3CL protease inhibitor in development as a long-acting injectable for prophylaxis treatment of SARS-CoV-2.<br /></div><a title="US HHS awards Shionogi $375M to develop COVID-19 PrEP therapy" class="more" href="https://www.bioworld.com/articles/716558-us-hhs-awards-shionogi-375m-to-develop-covid-19-prep-therapy">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="Drugs to Watch 2025: 11 potential blockbusters in the making" class="url" rel="" target="" href="https://www.bioworld.com/articles/716345-drugs-to-watch-2025-11-potential-blockbusters-in-the-making"><img width="650" height="488" alt="Drugs to Watch 2025 report cover" title="Drugs to Watch 2025 report cover" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/BW-source/2025/Drugs-to-Watch-2025-report-cover-1-8.jpg?height=488&t=1736371377&width=650" /></a></div> <div class="article-summary__details has-image"> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/716345-drugs-to-watch-2025-11-potential-blockbusters-in-the-making">Drugs to Watch 2025: 11 potential blockbusters in the making</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Jan. 14, 2025</div> <div class="author article-summary__author">By <a href="/authors/64-lee-landenberger">Lee Landenberger</a></div> <div class="comment-count article-summary__comment-count"><a title="Drugs to Watch 2025: 11 potential blockbusters in the making" class="more" href="https://www.bioworld.com/articles/716345-drugs-to-watch-2025-11-potential-blockbusters-in-the-making#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">The 2025 edition of Clarivate’s <em>Drugs to Watch</em> features 11 candidates or approved therapeutics that may well revolutionize treatments or become blockbusters. The 12<sup>th</sup> annual report has a strong track record. Twelve of the 13 drugs from the 2024 <em>Drugs to Watch</em> report have been approved and launched.<br /></div><a title="Drugs to Watch 2025: 11 potential blockbusters in the making" class="more" href="https://www.bioworld.com/articles/716345-drugs-to-watch-2025-11-potential-blockbusters-in-the-making">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/716340-yuhan-oscotec-stock-gains-as-j-and-j-hits-gold-standard-in-nsclc">Yuhan, Oscotec stock gains as J&J hits ‘gold standard’ in NSCLC</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Jan. 14, 2025</div> <div class="author article-summary__author">By <a href="/authors/603-marian-yoonjee-chu">Marian (YoonJee) Chu</a></div> <div class="comment-count article-summary__comment-count"><a title="Yuhan, Oscotec stock gains as J&J hits ‘gold standard’ in NSCLC" class="more" href="https://www.bioworld.com/articles/716340-yuhan-oscotec-stock-gains-as-j-and-j-hits-gold-standard-in-nsclc#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Yuhan Corp., Oscotec Inc. and Genosco Inc. were three companies with Asian ties to reap benefit from Johnson & Johnson’s stellar top-line Mariposa study results, wherein J&J’s Rybrevant (amivantamab-vmjw) and Lazcluze (lazertinib) combo regimen beat out Astrazeneca plc’s standard of care in non-small-cell lung cancer (NSCLC).<br /></div><a title="Yuhan, Oscotec stock gains as J&J hits ‘gold standard’ in NSCLC" class="more" href="https://www.bioworld.com/articles/716340-yuhan-oscotec-stock-gains-as-j-and-j-hits-gold-standard-in-nsclc">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="Sanofi expands SK Bio deal, starts phase III of GBP-410" class="url" rel="" target="" href="https://www.bioworld.com/articles/715763-sanofi-expands-sk-bio-deal-starts-phase-iii-of-gbp-410"><img width="650" height="488" alt="Photo of Jaeyong Ahn and Jean-Francois Toussant in signing ceremony" title="Photo of Jaeyong Ahn and Jean-Francois Toussant in signing ceremony" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/BW-source/2024/SK-Bioscience-Sanofi-12-23-hero.jpg?height=488&t=1734991626&width=650" /></a></div> <div class="article-summary__details has-image"> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/715763-sanofi-expands-sk-bio-deal-starts-phase-iii-of-gbp-410">Sanofi expands SK Bio deal, starts phase III of GBP-410</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Dec. 24, 2024</div> <div class="author article-summary__author">By <a href="/authors/603-marian-yoonjee-chu">Marian (YoonJee) Chu</a></div> <div class="comment-count article-summary__comment-count"><a title="Sanofi expands SK Bio deal, starts phase III of GBP-410" class="more" href="https://www.bioworld.com/articles/715763-sanofi-expands-sk-bio-deal-starts-phase-iii-of-gbp-410#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">SK Bioscience Co. Ltd. won €50 million (₩75.5 billion, US$52.03 million) up front from Sanofi SA to expand an earlier agreement to develop and commercialize novel pneumococcal conjugate vaccines (PCVs). The first deal resulted in GBP-410 (SP-0202), its pediatric 21-valent PCV candidate that moved into phase III study last week.<br /></div><a title="Sanofi expands SK Bio deal, starts phase III of GBP-410" class="more" href="https://www.bioworld.com/articles/715763-sanofi-expands-sk-bio-deal-starts-phase-iii-of-gbp-410">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/715764-china-gives-thumbs-up-to-innovents-taletrectinib-for-lung-cancer">China gives thumbs up to Innovent’s taletrectinib for lung cancer</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Dec. 24, 2024</div> <div class="author article-summary__author">By <a href="/authors/49-tamra-sami">Tamra Sami</a></div> <div class="comment-count article-summary__comment-count"><a title="China gives thumbs up to Innovent’s taletrectinib for lung cancer" class="more" href="https://www.bioworld.com/articles/715764-china-gives-thumbs-up-to-innovents-taletrectinib-for-lung-cancer#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">China's National Medical Products Administration (NMPA) approved Innovent Biologics Inc.’s NDA for Dovbleron (taletrectinib), a next-generation ROS1 tyrosine kinase inhibitor (TKI), for treating adults with locally advanced or metastatic ROS1-positive non-small cell lung cancer (NSCLC) who have been previously treated with ROS1 TKIs.<br /></div><a title="China gives thumbs up to Innovent’s taletrectinib for lung cancer" class="more" href="https://www.bioworld.com/articles/715764-china-gives-thumbs-up-to-innovents-taletrectinib-for-lung-cancer">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="Kura, Kyowa highlight positive combo data for ziftomenib" class="url" rel="" target="" href="https://www.bioworld.com/articles/715514-kura-kyowa-highlight-positive-combo-data-for-ziftomenib"><img width="650" height="488" alt="Acute myeloid leukemia" title="Acute myeloid leukemia" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Acute-myeloid-leukemia-(AML).png?height=488&t=1670008838&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">ASH 2024</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/715514-kura-kyowa-highlight-positive-combo-data-for-ziftomenib">Kura, Kyowa highlight positive combo data for ziftomenib</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Dec. 17, 2024</div> <div class="author article-summary__author">By <a href="/authors/49-tamra-sami">Tamra Sami</a></div> <div class="comment-count article-summary__comment-count"><a title="Kura, Kyowa highlight positive combo data for ziftomenib" class="more" href="https://www.bioworld.com/articles/715514-kura-kyowa-highlight-positive-combo-data-for-ziftomenib#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Kura Oncology, Inc. and Kyowa Kirin Co. Ltd.’s selective oral menin inhibitor ziftomenib showed encouraging data across multiple studies, the most encouraging of which were in combination with other standard of care therapies in patients with NPM1-mutant and KMT2A-rearranged acute myeloid leukemia.<br /></div><a title="Kura, Kyowa highlight positive combo data for ziftomenib" class="more" href="https://www.bioworld.com/articles/715514-kura-kyowa-highlight-positive-combo-data-for-ziftomenib">Read More</a> </div> </article> </div> <div class="pager"> <div role="navigation" aria-label="Pagination" class="pagination"><span class="previous_page disabled" aria-disabled="true">Previous</span> <em class="current" aria-label="Page 1" aria-current="page">1</em> <a rel="next" aria-label="Page 2" href="/articles/topic/86,153-clinical-bioworld-asia?page=2">2</a> <a aria-label="Page 3" href="/articles/topic/86,153-clinical-bioworld-asia?page=3">3</a> <a aria-label="Page 4" href="/articles/topic/86,153-clinical-bioworld-asia?page=4">4</a> <a aria-label="Page 5" href="/articles/topic/86,153-clinical-bioworld-asia?page=5">5</a> <a aria-label="Page 6" href="/articles/topic/86,153-clinical-bioworld-asia?page=6">6</a> <a aria-label="Page 7" href="/articles/topic/86,153-clinical-bioworld-asia?page=7">7</a> <a aria-label="Page 8" href="/articles/topic/86,153-clinical-bioworld-asia?page=8">8</a> <a aria-label="Page 9" href="/articles/topic/86,153-clinical-bioworld-asia?page=9">9</a> <span class="gap">…</span> <a aria-label="Page 45" href="/articles/topic/86,153-clinical-bioworld-asia?page=45">45</a> <a aria-label="Page 46" href="/articles/topic/86,153-clinical-bioworld-asia?page=46">46</a> <a class="next_page" rel="next" href="/articles/topic/86,153-clinical-bioworld-asia?page=2">Next</a></div> </div> </div> </div><aside class="main-interior-sidebar"><div class="main-interior-sidebar__column"><div id="article-recommendations"></div> </div><div class="main-interior-sidebar__column"><section class="popular-stories "> <h1 class="popular-stories__title">Popular Stories</h1><ul class="popular-stories__items"> <li class="popular-stories__item"> <article class="popular-stories__article popular-stories--article"><div class="popular-stories__details popular-stories__details-1"><h1 class="popular-stories__headline"><a class="popular-stories__article-title-link" href="https://www.bioworld.com/articles/432891-todays-news-in-brief">Today's news in brief</a></h1><div class="popular-stories__topics"><a class="popular-stories__topic-link" href="/topics/84-bioworld">BioWorld</a></div><div class="popular-stories__teaser"><em>BioWorld</em> briefs for Feb. 20, 2025.</div></div></article> </li> <li class="popular-stories__item"> <article class="popular-stories__article popular-stories--article"><div class="popular-stories__details popular-stories__details-1"><h1 class="popular-stories__headline"><a class="popular-stories__article-title-link" href="https://www.bioworld.com/articles/699574-todays-news-in-brief">Today's news in brief</a></h1><div class="popular-stories__topics"><a class="popular-stories__topic-link" href="/topics/85-bioworld-medtech">BioWorld MedTech</a></div><div class="popular-stories__teaser"><em>BioWorld MedTech</em> briefs for Feb. 20, 2025</div></div></article> </li> <li class="popular-stories__item"> <article class="popular-stories__article -has-image popular-stories--article"><figure class="popular-stories__image"><a class="popular-stories__thumbnail-link" data-eventname="popular-stories" data-eventcategory="click" data-eventaction="popular-stories-image" data-eventlabel="https://www.bioworld.com/articles/716928-european-vcs-bullish-on-med-tech-investments-in-2025" href="https://www.bioworld.com/articles/716928-european-vcs-bullish-on-med-tech-investments-in-2025"><img class="popular-stories__image-thumb" alt="White Euro symbol on blue background" title="White Euro symbol on blue background" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Money/Euro-currency-symbol-white.png?height=355&t=1669153720&width=640" /></a></figure><div class="popular-stories__details popular-stories__details-1"><h1 class="popular-stories__headline"><a class="popular-stories__article-title-link" href="https://www.bioworld.com/articles/716928-european-vcs-bullish-on-med-tech-investments-in-2025">European VCs bullish on med-tech investments in 2025</a></h1><div class="popular-stories__topics"><a class="popular-stories__topic-link" href="/topics/85-bioworld-medtech">BioWorld MedTech</a></div><div class="popular-stories__teaser">European companies looking for capital should find the fundraising environment more favorable in 2025. 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