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</ul> </nav> </div> </div> </div> </aside> </div> <main class="main-content col" id="content" role="main"> <section class="section"> <a id="main-content" tabindex="-1"></a> <div data-drupal-messages-fallback class="hidden"></div> <div data-drupal-messages>  </div> <div id="block-custom-base-theme-page-title" class="block block-core block-page-title-block"> <div class="content"> <h1 class="title"><span class="field field--name-title field--type-string field--label-hidden">Translational Liver Cancer (TLC) Consortium</span> </h1> </div> </div> <div id="block-custom-base-theme-content" class="block block-system block-system-main-block"> <div class="content"> <article data-history-node-id="922" about="/major-programs/translational-liver-cancer-tlc-consortium" class="node node--type-research-area node--view-mode-full clearfix"> <header> </header> <div class="node__content clearfix"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="align-right" media-view-mode="medium_size_image"> <div class="field field--name-field-media-image field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/medium/public/2023-02/mp-tlc.jpg?itok=vLDhDIQ4" width="300" height="200" typeof="foaf:Image" class="image-style-medium" alt> </div> </div> <p>The Translational Liver Cancer (TLC) Consortium was established to advance translational research focused on early detection of liver cancer. The consortium goals are to conduct studies to improve the surveillance of liver cancer in high-risk populations, increase the fraction of liver cancer detected at an early stage, and better stratify patients at risk of developing liver cancer.</p> <div id="nci-onthipage-list"> <p><strong>On This Page</strong></p> <ul> <li>All Headings will automatically be pulled in to this list.</li> <li>Do not edit the content on this template.</li> </ul> </div> <h2>About TLC</h2> <p>Liver cancer is the third most common cause of cancer-related death worldwide, and in the United States, liver cancer represents about 5% of all cancer deaths. The incidence of hepatocellular carcinoma (HCC) is three times higher in men than women, and there are racial and ethnic differences in liver cancer occurrence. The liver cancer burden is higher in African Americans, Hispanics, and Asians. The etiological/risk factors for liver cancer include viral hepatitis (Hepatitis B virus and Hepatitis C virus), non-alcoholic steatohepatitis (NASH), and alcoholic liver disease (ALD). Approximately 80-90% of HCC occurs in patients with underlying liver cirrhosis. Patients with advanced cirrhosis represent a high-risk group for liver cancer. This Consortium consists of five Translational Research Centers (supported by <a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-22-031.html">RFA-CA-22-031</a>, previously by <a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-17-025.html">RFA-CA-17-025</a>) and one Data Management and Coordinating Center (supported by <a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-22-032.html">RFA-CA-22-032</a>, previously by <a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-CA-17-028.html">RFA-CA-17-028</a>).</p> <p>These multidisciplinary teams address the following areas:</p> <ul> <li>Improving the surveillance for liver cancers in patients with cirrhosis;</li> <li>Increasing the detectability of liver cancers at early stages; and/or</li> <li>Approaches to better stratify patients with cirrhosis, who are at risk of developing liver cancer.</li> </ul> <p>To achieve these goals, the consortium consists of clinical researchers with multidisciplinary expertise in such areas as early cancer detection, biomarkers, surveillance, imaging, and biospecimen science.</p> <h2>Grantee Details</h2></div> <div class="field field--name-field-boxes field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--regular-row paragraph--view-mode--default _1col-100"> <div class="field field--name-field-add-a-box field--type-entity-reference-revisions field--label-hidden paragraph--type--columns__2col row field__items"> <div class="field__item mw-100" style="flex: 1;"> <div class="paragraph paragraph--type--view-box paragraph--view-mode--default card-bg-color-none"> <div class="field field--name-field-view field--type-viewsreference field--label-hidden"> <div class="field__item h-100"> <div class="views-element-container"> <div class="view view-grants view-id-grants view-display-id-grants_by_major_program 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class="field__item mw-100" style="flex: 1;"> <div class="paragraph paragraph--type--text-box paragraph--view-mode--default card-bg-color-none"> <div class="clearfix text-formatted field field--name-field-body-no-summary field--type-text-long field--label-hidden field__item"><h2>Program Contact(s)</h2> <p><strong>Sudhir Srivastava, Ph.D., M.P.H.</strong><br> <strong>Email:</strong> <a href="mailto:sudhir.srivastava@nih.gov">sudhir.srivastava@nih.gov</a></p> <p><strong>Sidney Fu, M.D.</strong><br> <strong>Email: </strong><a href="mailto:sidney.fu@nih.gov">sidney.fu@nih.gov</a></p> <p><strong>Matthew Young, Ph.D.</strong><br> <strong>Email:</strong> <a href="mailto:matthew.young@nih.gov">matthew.young@nih.gov</a></p> <p><strong>Guillermo Marquez, Ph.D.</strong><br> <strong>Email:</strong> <a href="mailto:guillermo.marquez@nih.gov">guillermo.marquez@nih.gov</a></p></div> </div> </div> </div> </div> </div> </div> </div> </article> </div> </div> </section> </main> </div> </div> </div> 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