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<!DOCTYPE html><html data-wf-domain="www.ascilion.com" data-wf-page="645b61127889fc9323e235e7" data-wf-site="5a2e5fada298f500011268d5"><head><meta charset="utf-8"/><title>Ascilion – Technology</title><meta content="A needle chip optimized for sampling of dermal interstitial fluid designed by world leading MEMS expertise and manufactured in a tier one volume foundry using a combination of deep reactive ion etching and wet etching of silicon, as well as other MEMS processes." name="description"/><meta content="Ascilion – Technology" property="og:title"/><meta content="A needle chip optimized for sampling of dermal interstitial fluid designed by world leading MEMS expertise and manufactured in a tier one volume foundry using a combination of deep reactive ion etching and wet etching of silicon, as well as other MEMS processes." property="og:description"/><meta content="https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/6461e05098f338eb3fc5c0fd_social1200px-10.jpg" property="og:image"/><meta content="Ascilion – Technology" property="twitter:title"/><meta content="A needle chip optimized for sampling of dermal interstitial fluid designed by world leading MEMS expertise and manufactured in a tier one volume foundry using a combination of deep reactive ion etching and wet etching of silicon, as well as other MEMS processes." property="twitter:description"/><meta content="https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/6461e05098f338eb3fc5c0fd_social1200px-10.jpg" property="twitter:image"/><meta property="og:type" content="website"/><meta content="summary_large_image" name="twitter:card"/><meta content="width=device-width, initial-scale=1" name="viewport"/><meta content="NVHdyLU8mHEgDs1oi58Pt75xrvdtL9ko5jETVYSw-cU" name="google-site-verification"/><meta content="Webflow" name="generator"/><link href="https://assets-global.website-files.com/5a2e5fada298f500011268d5/css/ascilion.webflow.450617b11.css" rel="stylesheet" type="text/css"/><link href="https://fonts.googleapis.com" rel="preconnect"/><link href="https://fonts.gstatic.com" rel="preconnect" crossorigin="anonymous"/><script src="https://ajax.googleapis.com/ajax/libs/webfont/1.6.26/webfont.js" type="text/javascript"></script><script type="text/javascript">WebFont.load({ google: { families: ["Open Sans:300,300italic,400,400italic,600,600italic,700,700italic,800,800italic","Lato:100,100italic,300,300italic,400,400italic,700,700italic,900,900italic","Roboto:300,regular,500"] }});</script><script type="text/javascript">!function(o,c){var n=c.documentElement,t=" w-mod-";n.className+=t+"js",("ontouchstart"in o||o.DocumentTouch&&c instanceof DocumentTouch)&&(n.className+=t+"touch")}(window,document);</script><link href="https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/5a2e9f707cc425000195188b_fav.jpg" rel="shortcut icon" type="image/x-icon"/><link href="https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/5a2e9fbda298f5000112b457_weblarge.jpg" rel="apple-touch-icon"/> <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-KJMMWVVG');</script>  <style type="text/css"> @media screen and (min-width: 1350px) { .w-container { max-width: 1350px; } } </style> <meta name="google-site-verification" content="NVHdyLU8mHEgDs1oi58Pt75xrvdtL9ko5jETVYSw-cU" /> </head><body class="body"><div data-w-id="8fc2c70b-9445-059e-9a99-47516183c453" data-animation="default" data-collapse="medium" data-duration="400" data-easing="ease" data-easing2="ease" role="banner" class="navbar w-nav"><div class="navbar-container w-container"><a href="/" class="logotype-link w-nav-brand"><img src="https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/645b62ec8c124f1151141509_ascilion_white.svg" loading="lazy" alt="" class="logotype-top"/></a><nav role="navigation" class="nav-menu w-nav-menu"><a href="/" class="nav-link w-nav-link">Home</a><a href="/products" class="nav-link w-nav-link">Products</a><a href="/technology" aria-current="page" class="nav-link w-nav-link w--current">Technology</a><a href="/applications" class="nav-link w-nav-link">Application areas</a><a href="/about" class="nav-link w-nav-link">About us</a><a href="/contactus" class="nav-link w-nav-link">Contact</a></nav><div class="menu-button w-nav-button"><div class="w-icon-nav-menu"></div></div></div></div><section class="_23-hero"><div class="_23-hero-container w-container"><div class="_23-hero-div-subpages"><h1 data-w-id="01efa84b-d931-46d9-5e8e-a9afa1a952b9" style="opacity:0" class="h1-hero">Sampling of dermal Interstitial Fluid (dISF)</h1><h2 data-w-id="630c03ab-cc23-b9d9-6b63-696d3949c2f3" style="opacity:0" class="h2-hero center">Technology</h2><div data-w-id="8c1215b0-3115-57b0-3826-e0e72d543a86" style="opacity:0" class="line center"></div><div data-w-id="11366be4-fbf9-6c50-68b4-979a350e79a9" style="opacity:0" class="text-main bold">A needle chip optimized for sampling of dermal interstitial fluid designed by world leading MEMS expertise and manufactured in a tier one volume foundry using a combination of deep reactive ion etching and wet etching of silicon, as well as other MEMS processes.<br/></div></div></div></section><div class="_23-section-white"><div class="_90-90 tight w-container"><h3 class="h3">The Challenge</h3><div data-w-id="d5fd6d0c-73ba-32a5-6d3c-3c6a62795884" style="opacity:0" class="line smallred"></div><div data-w-id="a8d568fe-91fe-6aaa-4ba0-90a6c53d4c7d" style="opacity:0" class="richtext-main w-richtext"><p>Dermal interstitial fluid, as opposed to the bloodstream, is not under positive pressure. The fluid isn’t easy to sample. All parts of a system intended for sampling of dermal interstitial fluid need to be highly optimized and work in conjunction for an efficient sampling process. </p><h6>Ascilion has spent over a decade refining every part of the system from the needle chip to the instrument controlling the process via the method for how the parts fit together with maintained sterility.</h6></div></div></div><div class="_23-section-grid"><div class="w-layout-grid _2-grid nospace"><div id="w-node-_7b4802dc-45e3-f344-ec3d-fcf5adf1a771-23e235e7" data-w-id="7b4802dc-45e3-f344-ec3d-fcf5adf1a771" style="opacity:0" class="griddiv p4"></div><div id="w-node-e5e72ab6-51b3-160e-acf7-e36f939c3a3f-23e235e7" data-w-id="e5e72ab6-51b3-160e-acf7-e36f939c3a3f" style="opacity:0" class="griddiv isf2"><h3 class="h3">Dermal Interstitial Fluid</h3><div class="line smallred"></div><div class="text-main bold">Biomarkers found in dermal interstitial fluid, a compartment close to cell activity, are often more relevant for analysis compared to those collected from blood sampling.</div><div class="text-main">Dermal interstitial fluid is still largely unexplored because it has traditionally been very difficult to access. Furthermore, sampling processes have caused pain and discomfort, often resulting in an unwanted alteration of the content of the sample due to use of for instance local anesthesia or simply the invasive nature of the method.</div><div class="text-main bold">This all changes with the simplicity of Ascilion’s microneedle system.</div></div></div></div><div class="_23-section-grid"><div class="w-layout-grid _2-grid nospace"><div id="w-node-b855c25b-db2c-c7ae-fdbb-620add87273e-23e235e7" data-w-id="b855c25b-db2c-c7ae-fdbb-620add87273e" style="opacity:0" class="griddiv benefits1"><h3 class="h3">Hollow Silicon Microneedles</h3><div class="line smallred"></div><div class="text-main">Microneedles made from monocrystalline silicon are at the core of Ascilion's dISF sampling solution. Multiple hollow microneedles, fabricated to form a precisely engineered pattern, are combined with a capillary system that enables robust sampling and collection of the fluid.</div><div class="text-main bold">With a needle length of less than 0.5 mm, the sampling process is truly minimally invasive.</div></div><div id="w-node-eabe6bf9-fb89-6ac8-f111-a26d5da2a27a-23e235e7" data-w-id="eabe6bf9-fb89-6ac8-f111-a26d5da2a27a" style="opacity:0" class="griddiv needles"></div></div></div><div class="_23-section-grid"><div class="w-layout-grid _2-grid nospace"><div id="w-node-_8119e749-e69b-f39c-d12c-418462f5022a-23e235e7" data-w-id="8119e749-e69b-f39c-d12c-418462f5022a" style="opacity:0" class="griddiv benefits2"><div data-poster-url="https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/645b7c5f40e38a231ef952ec_ChipFillsUp-1-poster-00001.jpg" data-video-urls="https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/645b7c5f40e38a231ef952ec_ChipFillsUp-1-transcode.mp4,https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/645b7c5f40e38a231ef952ec_ChipFillsUp-1-transcode.webm" data-autoplay="true" data-loop="true" data-wf-ignore="true" class="video-benefits w-background-video w-background-video-atom"><video id="8119e749-e69b-f39c-d12c-418462f5022b-video" autoplay="" loop="" style="background-image:url("https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/645b7c5f40e38a231ef952ec_ChipFillsUp-1-poster-00001.jpg")" muted="" playsinline="" data-wf-ignore="true" data-object-fit="cover"><source src="https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/645b7c5f40e38a231ef952ec_ChipFillsUp-1-transcode.mp4" data-wf-ignore="true"/><source src="https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/645b7c5f40e38a231ef952ec_ChipFillsUp-1-transcode.webm" data-wf-ignore="true"/></video></div></div><div id="w-node-_8119e749-e69b-f39c-d12c-418462f5022c-23e235e7" data-w-id="8119e749-e69b-f39c-d12c-418462f5022c" style="opacity:0" class="griddiv isf2"><h3 class="h3">Integrated Capillary System</h3><div class="line smallred"></div><div class="text-main">All needles are connected using an integrated capillary system that drives the fluid towards a collection reservoir. The capillaries are manufactured for optimal fluidic properties by a combination of deep reactive ion etching of silicon and anodic bonding of glass utilizing state of the art MEMS processing.</div></div></div></div><div class="_23-section-white space hide"><div class="_50-50 tight w-container"><h3 data-w-id="d6380d8b-5b31-c00a-f423-b6c94cc2f756" style="opacity:0" class="h3">Lorum ipsum<br/></h3><div data-w-id="d6380d8b-5b31-c00a-f423-b6c94cc2f759" style="opacity:0" class="line smallred"></div><div data-w-id="d6380d8b-5b31-c00a-f423-b6c94cc2f75a" style="opacity:0" class="richtext-main w-richtext"><h4>Lorum ipsum</h4><p>Lorum ipsum dolor sit amet. Sed dium nonum nibb euismod tincidunt ut laorect dolore magna aliquam erat volutpat. Ust wist enim ad minim. Venium quis nostrud exertci tation. Lorum ipsum dolor sit amet. Sed dium nonum nibb euismod tincidunt ut laorect dolore magna aliquam erat volutpat.</p><p>Lorum ipsum dolor sit amet. 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Sed dium nonum nibb euismod tincidunt ut laorect dolore magna aliquam erat volutpat.</p></div></div></div><div class="_23-section-bigvideo hide"><div data-poster-url="https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/645b7db154132aa29355250b_INTERSTITIAL-FLUID-1-poster-00001.jpg" data-video-urls="https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/645b7db154132aa29355250b_INTERSTITIAL-FLUID-1-transcode.mp4,https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/645b7db154132aa29355250b_INTERSTITIAL-FLUID-1-transcode.webm" data-autoplay="true" data-loop="true" data-wf-ignore="true" class="background-video w-background-video w-background-video-atom"><video id="61348d32-21f9-1e60-f25a-2060bfb21f50-video" autoplay="" loop="" style="background-image:url("https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/645b7db154132aa29355250b_INTERSTITIAL-FLUID-1-poster-00001.jpg")" muted="" playsinline="" data-wf-ignore="true" data-object-fit="cover"><source src="https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/645b7db154132aa29355250b_INTERSTITIAL-FLUID-1-transcode.mp4" data-wf-ignore="true"/><source src="https://cdn.prod.website-files.com/5a2e5fada298f500011268d5/645b7db154132aa29355250b_INTERSTITIAL-FLUID-1-transcode.webm" data-wf-ignore="true"/></video><div class="_50-50 white w-container"><div class="_50"><h3 data-w-id="401e7839-73b7-e802-46fc-fac55dec3903" style="opacity:0" class="h3 white">Lorum ipsum<br/></h3><div data-w-id="401e7839-73b7-e802-46fc-fac55dec3906" style="opacity:0" class="line smallwhite"></div><div data-w-id="401e7839-73b7-e802-46fc-fac55dec3907" style="opacity:0" class="text-main">Lorum ipsum dolor sit amet. Sed dium nonum nibb euismod tincidunt ut laorect dolore magna aliquam erat volutpat. Ust wist enim ad minim. Venium quis nostrud exertci tation. Lorum ipsum dolor sit amet. Sed dium nonum nibb euismod tincidunt ut laorect dolore magna aliquam erat volutpat.</div><a data-w-id="893fa54f-a1b1-0503-a8b9-ebd8ca37db89" style="opacity:0" href="#" class="textlink white">Read more</a></div></div></div></div><div class="_23-section-grid hide"><div class="w-layout-grid _2-grid nospace"><div id="w-node-_1808d292-d7db-3353-51b8-cafc2218848b-23e235e7" data-w-id="1808d292-d7db-3353-51b8-cafc2218848b" style="opacity:0" class="griddiv red"><h3 class="h3 white">Lorum ipsum</h3><div class="line smallwhite"></div><div class="text-main">Lorum ipsum dolor sit amet. Sed dium nonum nibb euismod tincidunt ut laorect dolore magna aliquam erat volutpat. Ust wist enim ad minim. Venium quis nostrud exertci tation. Lorum ipsum dolor sit amet. 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