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eplerenone | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
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href="/about.jsp">About</a> <a href="/helpPage.jsp">Help</a> <div class="navbar-search-container"> <form method="get" action="/GRAC/DatabaseSearchForward" class="search_box_dropbar"> <input type="text" title="Quick Search Box" id="quick_search_dropnav" size="14" maxlength="200" name="searchString" placeholder="Search GtoPdb..."/> <input type="hidden" name="searchCategories" value="all"/> <input type="hidden" name="species" value="none"/> <input type="hidden" name="type" value="all"/> <input type="hidden" name="comments" value="includeComments"/> <input type="hidden" name="order" value="rank"/> <button type="submit" aria-label="Search button"><i class="fa fa-search"></i></button> </form> <script> $("#quick_search_dropnav").catcomplete({delay: 300, minLength: 2, source: "/GRAC/autocompleteAll.jsp", focus: function( event, ui ) { // $( "#ligand_text" ).val( ui.item.label ); // do nothing on mouse over return false; }, select: function( event, ui ) { //window.open(ui.item.value); self.location.href = ui.item.value; return false; } }); </script> </div> </div> </div> <!-- ========== SUPERFISH NAV END ============================================================ --> <div class="container_16"> <!-- ==================== BREADCRUMBS START - NEEDS TO BE UPDATED MANUALLY ==================== --> <div class="breadcrumbscont"> <ul class="crumbtext"> <li><a href="/index.jsp">Home</a></li> <li><a href="LigandListForward?database=all">Ligands</a></li> <li>eplerenone</li> </ul> </div> <!-- ==================== BREADCRUMBS END ======================================== --> <!-- ==================== CONTENT START ==================== --> <div class="grid_12"> <!-- ==================== GRID 16 START ==================== --> <!-- ==================== GRID 16 START ==================== --> <div class="grid_16 alpha"> <div id="ligandheader"> <h4 class="alignlefttitle">eplerenone <a href="JavaScript:callRef('helpPagePopup.jsp#ligand', 800, 400)" title="Click here for help"><img style="vertical-align:middle; height:22px;" src="images/white_transparent_help_icon.png" alt="Click here for help"/></a></h4> <h4 class="alignright">GtoPdb Ligand ID: 2876</h4> </div> <div style="clear: both;"></div> <div class="contentboxfullhelp"> <table class="fullwidth" style="position:relative; margin-bottom: 10px;"> <tr> <td style="width:453px;min-width:453px;text-align:left;vertical-align:top;"> <div class="textright_ligsum"> <b>Synonyms:</b> Inspra® | SC-66110 </div> <div class="textright_ligsum"> <a style="color:white; padding-right:8px;" title="Approved drug" ><img style="vertical-align:baseline;" src="images/approved.png" height="22px" alt="Approved drug"/></a> <a style="color:white; padding-right:8px;" title="Ligand has a PDB structure"><img src="images/protein_structure_icon.png" height="22px" alt="PDB Ligand"/></a> </div> <div class="textright_ligsum">eplerenone is an <b>approved drug</b> (FDA (2002))</div> <div class="textright_ligsum"><b>Compound class:</b> <a href="LigandListForward?type=Synthetic-organic" > Synthetic organic </a></div> <div class="textright_ligsum"> <b>Comment:</b> Eplerenone is a potassium-sparing diuretic, which works by antagonising the effects of aldosterone. </div> <div class="imageleft" style="margin-top:10px;"><a class="popup-trigger" rel="nofollow" title="Ligand activity charts help"><img style="vertical-align:baseline; height:20px;" src="images/gtopblue_transparent_help_icon.png" alt="Click here for help" onmouseover="this.src='images/gtopblue_transparent_help_icon_hover.png';" onmouseout="this.src='images/gtopblue_transparent_help_icon.png';")"/></a> <div class="popup" style="text-align:left;"> <h3>Ligand Activity Visualisation Charts</h3> <p>These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.</p> <span class="popup-btn-close">✖</span> <!-- add wee help video <p><video align="center" width="380" controls="true" autoplay="false" > <source src="videos/gtoimmupdb_processes_v1.mp4" type="video/mp4"> </video></p> --> </div> </div> <div class="textright_ligactchr" style="margin-top:18px;"><p style="font-weight: bold;"> <a href="LigandActivityRangeVisForward?ligandId=2876" target="_blank"> <!-- <i class="fa-solid fa-chart-bar" style="color: #1e3363;"></i> --> <i class="fa fa-bar-chart fa-2x" style="color: #1e3363;"></i> View interactive charts of activity data across species</a></p> </div> <div class="imageleft" style="margin-top:30px;"> <img style="vertical-align:baseline;" src="images/PEP_thumb.jpg" alt="IUPHAR Pharmacology Education Project (PEP) logo" width="55px"/> </div> <div class="textright" style="margin-top:50px;"> <p style="margin-bottom:30px;"> View more information in the IUPHAR Pharmacology Education Project: <a href="http://www.pharmacologyeducation.org/site-search-page/eplerenone" target="_blank" title="IUPHAR Pharmacology Education Project (PEP)" onClick="recordEvent(this, 'Ligand database links', 'http://www.pharmacologyeducation.org/site-search-page/eplerenone', 'IUPHAR Pharmacology Education Project (PEP)');return false;">eplerenone</a> </p> </div> <!-- new link - Sep 2022 - to jump to supplier logos/links if available --> <div class="textright_ligsum"> <p style="padding:0px;"> <a href="LigandDisplayForward?tab=summary&ligandId=2876#Suppliers"> <!--<i class="fa fa-shopping-bag fa-2x" style="color: #1e3363;"></i>--><b> eplerenone</b> is commercially available from our sponsors</a> </p> </div> </td> <td style="min-width:10px;width:10px;"></td> <td style="width:453px;min-width:453px;text-align:left;vertical-align:top;"> <table id="structure_and_props" class="tablesorter inner_receptor_data_tables" style="width:453px;margin:0px;"> <tbody> <tr class="info"> <td class="ligand_header_category" colspan="2"><div class="imageleft">2D Structure </div><div><a class="popup-trigger" rel="nofollow" title="2D structure help"><img style="vertical-align:middle; height:19px;margin-left:5px;" src="images/gtopblue_transparent_help_icon.png" alt="Click here for help" onmouseover="this.src='images/gtopblue_transparent_help_icon_hover.png';" onmouseout="this.src='images/gtopblue_transparent_help_icon.png';")"/></a> <div class="popup" style="text-align:left;"> <h3>2D Structure</h3> <p>An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.</p> <span class="popup-btn-close">✖</span> <!-- add wee help video <p><video align="center" width="380" controls="true" autoplay="false" > <source src="videos/gtoimmupdb_processes_v1.mp4" type="video/mp4"> </video></p> --> </div> </div></td> </tr> <tr class="info"> <td style="vertical-align:middle;text-align:center;height:250px;" colspan="2"> <a style="color:white;" href="RefineChemicalStructureSearchForward?ligandId=2876" title="Click here for structure editor"> <img id="ligand_structure_display" src="https://www.guidetopharmacology.org/CHEMSTRUCT/iuphar/2876.gif" onerror="this.src='https://www.simolecule.com/cdkdepict/depict/cot/svg?smi=COC%28%3DO%29%5BC%40%40H%5D1CC2%3DCC%28%3DO%29CC%5BC%40%40%5D2%28%5BC%40%40%5D23%5BC%40%40H%5D1%5BC%40%40H%5D1CC%5BC%40%5D4%28%5BC%40%40%5D1%28C%29C%5BC%40H%5D3O2%29CCC%28%3DO%29O4%29C&abbr=on&hdisp=bridgehead&showtitle=false&annotate=none'" alt="Click here for structure editor"/> </a> </td> </tr> <tr class="info"> <td class="ligand_header_category"><div class="imageleft">Physico-chemical Properties </div><div><a class="popup-trigger" rel="nofollow" title="Physico-chemical properties help"><img style="vertical-align:middle; height:19px;margin-left:5px;" src="images/gtopblue_transparent_help_icon.png" alt="Click here for help" onmouseover="this.src='images/gtopblue_transparent_help_icon_hover.png';" onmouseout="this.src='images/gtopblue_transparent_help_icon.png';")"/></a> <div class="popup" style="text-align:left;"> <h3>Physico-chemical Properties</h3> <p>Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the <a href="JavaScript:callRef('helpPagePopup.jsp#ligProperties', 800, 400)">help pages</a>.</p> <span class="popup-btn-close">✖</span> <!-- add wee help video <p><video align="center" width="380" controls="true" autoplay="false" > <source src="videos/gtoimmupdb_processes_v1.mp4" type="video/mp4"> </video></p> --> </div> </div></td> <td title="toggle" style="min-width:30px;width:30px;background-color:#CCCCCC" valign="middle"> <a name="chemprops" title="view physico-chemical properties" class="toggle"><div class="arrow"></div></a> </td> </tr> <tr class="tablesorter-childRow info"> <td colspan="2"> <table style="width: 100%; border: none; border-collapse: collapse;" class="info"> <tr class="info"> <td> Hydrogen bond acceptors </td> <td style="text-align:center"> 6 </td> </tr> <tr class="info"> <td> Hydrogen bond donors </td> <td style="text-align:center"> 0 </td> </tr> <tr class="info"> <td> Rotatable bonds </td> <td style="text-align:center"> 2 </td> </tr> <tr class="info"> <td> Topological polar surface area </td> <td style="text-align:center"> 82.2 </td> </tr> <tr class="info"> <td> Molecular weight </td> <td style="text-align:center"> 414.2 </td> </tr> <tr class="info"> <td> XLogP </td> <td style="text-align:center"> 1.32 </td> </tr> <tr class="info"> <td> No. Lipinski's rules broken </td> <td style="text-align:center"> 0 </td> </tr> </table> </td> </tr> <tr class="info"> <td class="ligand_header_category"><div class="imageleft">SMILES / InChI / InChIKey </div><div><a class="popup-trigger" rel="nofollow" title="SMILES and InChI help"><img style="vertical-align:middle; height:19px;margin-left:5px;" src="images/gtopblue_transparent_help_icon.png" alt="Click here for help" onmouseover="this.src='images/gtopblue_transparent_help_icon_hover.png';" onmouseout="this.src='images/gtopblue_transparent_help_icon.png';")"/></a> <div class="popup" style="text-align:left;"> <h3>SMILES / InChI / InChIKey</h3> <p><b>SMILES</b> (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.<br><br> <b>Standard InChI</b> (IUPAC International Chemical Identifier) and <b>InChIKey</b> InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.</p> <span class="popup-btn-close">✖</span> <!-- add wee help video <p><video align="center" width="380" controls="true" autoplay="false" > <source src="videos/gtoimmupdb_processes_v1.mp4" type="video/mp4"> </video></p> --> </div> </div></td> <td title="toggle" style="min-width:30px;width:30px;background-color:#CCCCCC" valign="middle"> <a name="smilesinchi" title="view SMILES, InchI and InChI Key" class="toggle"><div class="arrow"></div></a> </td> </tr> <tr class="tablesorter-childRow info"> <td colspan="2"> <table style="width: 100%; border: none; border-collapse: collapse; word-break:break-word;" class="info"> <tr class="info"> <td style="text-align:left; min-width:60px;"> Canonical SMILES </td> <td style="text-align:left;" > COC(=O)C1CC2=CC(=O)CCC2(C23C1C1CCC4(C1(C)CC3O2)CCC(=O)O4)C </td> </tr> <tr class="info"> <td style="text-align:left; min-width:60px;"> Isomeric SMILES </td> <td style="text-align:left;" > COC(=O)[C@@H]1CC2=CC(=O)CC[C@@]2([C@@]23[C@@H]1[C@@H]1CC[C@]4([C@@]1(C)C[C@H]3O2)CCC(=O)O4)C </td> </tr> <tr class="info"> <td style="text-align:left; min-width:60px;"> InChI </td> <td style="text-align:left; min-width:60px;" > InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1 </td> </tr> <tr class="info"> <td style="text-align:left;"> InChI Key </td> <td style="text-align:left;" > JUKPWJGBANNWMW-VWBFHTRKSA-N </td> </tr> </table> </td> </tr> </tbody> </table> <script type="text/javascript"> $(function(){ $("#structure_and_props").tablesorter(); }); </script> </td> </tr> </table> </div> </div> <!-- ==================== GRID 16 START ==================== --> <div class="grid_16 alpha"> <div class="contentboxfullhelp"> <div id='cssmenu'> <ul > <li class='active'><a href="LigandDisplayForward?tab=summary&ligandId=2876">Summary</a></li> <li ><a href="LigandDisplayForward?tab=biology&ligandId=2876">Biological activity</a></li> <li ><a href="LigandDisplayForward?tab=clinical&ligandId=2876">Clinical data</a></li> <li ><a href="LigandDisplayForward?tab=refs&ligandId=2876">References</a></li> <li ><a href="LigandDisplayForward?tab=structure&ligandId=2876">Structure</a></li> <li ><a href="LigandDisplayForward?tab=similarity&ligandId=2876">Similar ligands</a></li> </ul> </div> <div class="clear"></div> <div class="data_tables_container" style="padding-top:10px; padding-bottom: 10px;"><!-- === DATA TABLES START - this div is only needed to give some space around the tables === --> <table class="receptor_data_tables" style="width:100%;"> <tr> <td class="category" colspan="2">Classification <a style="color:#CCCCCC;" href="JavaScript:callRef('helpPagePopup.jsp#ligClass', 800, 400)" title="Click here for help"><img style="vertical-align:baseline;" src="images/help_blue_small_transparent_bkground.png" alt="Click here for help"/></a></td> </tr> <tr> <td class="info" align="left" style="min-width:250px;max-width:250px;width:250px;">Compound class</td> <td class="info"> <a href="LigandListForward?type=Synthetic-organic" > Synthetic organic </a> </td> </tr> <tr> <td class="info" align="left" style="min-width:250px;max-width:250px;width:250px;">Approved drug?</td> <td class="info">Yes (FDA (2002))</td> </tr> </table> <table class="receptor_data_tables" style="width:100%;"> <tr> <td class="category">IUPAC Name <a style="color:#CCCCCC;" href="JavaScript:callRef('helpPagePopup.jsp#ligIUPAC', 800, 400)" title="Click here for help"><img style="vertical-align:baseline;" src="images/help_blue_small_transparent_bkground.png" alt="Click here for help"/></a></td> </tr> <tr class="info"> <td>methyl (1'R,2R,2'S,9'R,10'R,11'S,15'S,17'R)-2',15'-dimethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo[8.8.0.0^{1,17}.0^{2,7}.0^{11,15}]octadecan]-6'-ene-9'-carboxylate</td> </tr> </table> <table class="receptor_data_tables" style="width:100%;"> <tr> <td class="category" colspan="2">International Nonproprietary Names <a style="color:#CCCCCC;" href="JavaScript:callRef('helpPagePopup.jsp#INN', 800, 400)" title="Click here for help"><img style="vertical-align:baseline;" src="images/help_blue_small_transparent_bkground.png" alt="Click here for help"/></a></td> </tr> <tr> <td class="heading">INN number</td> <td class="heading">INN</td> </tr> <tr class="info"> <td>7596</td> <td>eplerenone </tr> </table> <table class="receptor_data_tables" style="width:100%;"> <tr> <td class="category" >Synonyms <a style="color:#CCCCCC;" href="JavaScript:callRef('helpPagePopup.jsp#ligSynonyms', 800, 400)" title="Click here for help"><img style="vertical-align:baseline;" src="images/help_blue_small_transparent_bkground.png" alt="Click here for help"/></a></td> </tr> <tr class="info"> <td> Inspra® | SC-66110 </td> </tr> </table> <a name="DatabaseLinks"></a> <table class="receptor_data_tables" style="width:100%;"> <tr> <td class="category" colspan="2">Database Links <a style="color:#CCCCCC;" href="JavaScript:callRef('helpPagePopup.jsp#ligDBLinks', 800, 400)" title="Click here for help"><img style="vertical-align:baseline;" src="images/help_blue_small_transparent_bkground.png" alt="Click here for help"/></a></td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> BindingDB Ligand </td> <td class="info"> <a href="http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324120" target="_blank" title="Database of measured binding affinities" onClick="recordEvent(this, 'Ligand database links', 'http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324120', 'BindingDB Ligand');return false;">50324120</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> CAS Registry No. </td> <td class="info"> 107724-20-9 </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> ChEBI </td> <td class="info"> <a href="http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:31547" target="_blank" title="Chemical Entities of Biological Interest: dictionary of molecular entities focused on 'small' chemical compounds" onClick="recordEvent(this, 'Ligand database links', 'http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:31547', 'ChEBI');return false;">CHEBI:31547</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> ChEMBL Ligand </td> <td class="info"> <a href="https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1095097" target="_blank" title="Database of bioactive drug-like small molecules and targets" onClick="recordEvent(this, 'Ligand database links', 'https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1095097', 'ChEMBL Ligand');return false;">CHEMBL1095097</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> DrugBank Ligand </td> <td class="info"> <a href="http://www.drugbank.ca/drugs/DB00700" target="_blank" title="Detailed drug (chemical, pharmacological and pharmaceutical) data with information on drug target/enzyme/transporter/carrier proteins" onClick="recordEvent(this, 'Ligand database links', 'http://www.drugbank.ca/drugs/DB00700', 'DrugBank Ligand');return false;">DB00700</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> DrugCentral Ligand </td> <td class="info"> <a href="http://drugcentral.org/drugcard/1032" target="_blank" title="DrugCentral is created and maintained by Division of Translational Informatics at University of New Mexico in collaboration with the IDG program. DrugCentral provides information on active ingredients chemical entities, pharmaceutical products, drug mode of action, indications, pharmacologic action." onClick="recordEvent(this, 'Ligand database links', 'http://drugcentral.org/drugcard/1032', 'DrugCentral Ligand');return false;">1032</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> GtoPdb PubChem SID </td> <td class="info"> <a href="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=135650235" target="_blank" title="Database of chemical structures and information on their biological activities. This link is to the GtoPdb-deposited PubChem Substance entry." onClick="recordEvent(this, 'Ligand database links', 'http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=135650235', 'GtoPdb PubChem SID');return false;">135650235</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> PubChem CID </td> <td class="info"> <a href="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=443872" target="_blank" title="Database of chemical structures and information on their biological activities. The PubChem Compound Database contains validated chemical depiction information." onClick="recordEvent(this, 'Ligand database links', 'http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=443872', 'PubChem CID');return false;">443872</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> RCSB PDB Ligand </td> <td class="info"> <a href="http://www.rcsb.org/ligand/YNU" target="_blank" title="RCSB Protein Data Bank ligand" onClick="recordEvent(this, 'Ligand database links', 'http://www.rcsb.org/ligand/YNU', 'RCSB PDB Ligand');return false;">YNU</a>, <a href="http://www.rcsb.org/ligand/YNU" target="_blank" title="RCSB Protein Data Bank ligand" onClick="recordEvent(this, 'Ligand database links', 'http://www.rcsb.org/ligand/YNU', 'RCSB PDB Ligand');return false;">YNU</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> Search Google for chemical match using the InChIKey </td> <td class="info"> <a href="https://www.google.com/search?q=JUKPWJGBANNWMW-VWBFHTRKSA-N" target="_blank" title="Search Google for exact chemical matches using the InChI key" onClick="recordEvent(this, 'Ligand database links', 'https://www.google.com/search?q=JUKPWJGBANNWMW-VWBFHTRKSA-N', 'Google InChIKey exact match search');return false;">JUKPWJGBANNWMW-VWBFHTRKSA-N</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> Search Google for chemicals with the same backbone </td> <td class="info"> <a href="https://www.google.com/search?q=JUKPWJGBANNWMW" target="_blank" title="Search Google for chemicals with the same backbone structure using the InChI key outer layer" onClick="recordEvent(this, 'Ligand database links', 'https://www.google.com/search?q=JUKPWJGBANNWMW', 'Google InChIKey backbone search');return false;">JUKPWJGBANNWMW</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> Search PubMed clinical trials </td> <td class="info"> <a href='http://www.ncbi.nlm.nih.gov/pubmed/?term=eplerenone[Title]+AND+("clinical+trial+phase+i"[Filter]+OR+"clinical+trial+phase+ii"[Filter]+OR+"clinical+trial+phase+iii"[Filter]+OR+"clinical+trial+phase+iv"[Filter])' target="_blank" title="Search PubMed for articles describing phase I, II, III or IV clinical trials involving this drug" onClick="recordEvent(this, 'Ligand database links', 'NCBI PubMed Clinical Trials INN search: eplerenone', 'NCBI PubMed Clinical Trials INN search');return false;">eplerenone</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> Search PubMed titles </td> <td class="info"> <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=eplerenone[Title]&cmd=DetailsSearch" target="_blank" title="Search PubMed for articles mentioning this chemical name in the title" onClick="recordEvent(this, 'Ligand database links', 'NCBI PubMed Title INN search: eplerenone', 'NCBI PubMed Title INN search');return false;">eplerenone</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> Search PubMed titles/abstracts </td> <td class="info"> <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=eplerenone[Title%2FAbstract]&cmd=DetailsSearch" target="_blank" title="Search PubMed for articles mentioning this chemical name in the title or abstract" onClick="recordEvent(this, 'Ligand database links', 'NCBI PubMed Title and Abstract INN search: eplerenone', 'NCBI PubMed Title and Abstract INN search');return false;">eplerenone</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> UniChem Compound Search for chemical match using the InChIKey </td> <td class="info"> <a href="https://www.ebi.ac.uk/unichem/compoundsources?type=inchikey&compound=JUKPWJGBANNWMW-VWBFHTRKSA-N" target="_blank" title="UniChem Compound Search finds source for a given compound via InChIkey" onClick="recordEvent(this, 'Ligand database links', 'https://www.ebi.ac.uk/unichem/compoundsources?type=inchikey&compound=JUKPWJGBANNWMW-VWBFHTRKSA-N', 'UniChem InChIKey Compound Search');return false;">JUKPWJGBANNWMW-VWBFHTRKSA-N</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> UniChem Connectivity Search for chemical match using the InChIKey </td> <td class="info"> <a href="https://www.ebi.ac.uk/unichem/search/connectivity?type=inchikey&compound=JUKPWJGBANNWMW-VWBFHTRKSA-N" target="_blank" title="UniChem Connectivity Search fetches multiple source data sets for a given compound with common connectivity to a given InChIkey" onClick="recordEvent(this, 'Ligand database links', 'https://www.ebi.ac.uk/unichem/search/connectivity?type=inchikey&compound=JUKPWJGBANNWMW-VWBFHTRKSA-N', 'UniChem InChIKey Connectivity Search');return false;">JUKPWJGBANNWMW-VWBFHTRKSA-N</a> </td> </tr> <tr> <td class="info" style="min-width:250px;max-width:250px;width:250px;"> Wikipedia </td> <td class="info"> <a href="http://en.wikipedia.org/wiki/Eplerenone" target="_blank" title="The Free Encyclopedia" onClick="recordEvent(this, 'Ligand database links', 'http://en.wikipedia.org/wiki/Eplerenone', 'Wikipedia');return false;">Eplerenone</a> </td> </tr> </table> <a id="Suppliers"></a> <div style="display: flex;"> <div style="max-width:500px;"> <h3>Product suppliers</h3> </div> <div style="flex-grow: 1;"> <h3 style="text-align:left;"> <a class="popup-trigger" rel="nofollow" title="Click to display GtoPdb sponsored products disclaimer" style="padding-left:40px; color:#1e3363;">View disclaimer</a> <div class="popup" style="text-align:left;"><h3>Sponsored products disclaimer</h3> <p>Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.</p><p>Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please <a href="/revealEmail.jsp" onclick="window.open('/revealEmail.jsp', '', 'toolbar=0,scrollbars=0,location=0,statusbar=0,menubar=0,resizable=0,width=550,height=300'); return false;" title="Reveal this e-mail address">contact us</a>.</p><span class="popup-btn-close">✖</span> </div> </h3> </div> </div> <table class="receptor_data_tables" style="width:100%;margin-top:10px;"> <tr> <td style="width: 33%; vertical-align: top; padding-top: 10px; padding-left: 5px; padding-right:5px;" > <div style="margin-bottom:10px;"> <a style="color:white;" href="https://www.tocris.com/products/eplerenone_2397" target="_blank" onClick="recordEvent(this, 'Supplier links', 'https://www.tocris.com/products/eplerenone_2397', 'Tocris Outbound Link 2397 Eplerenone');return false;"><img src="images/Tocris-Biotechne_200.png" alt="Tocris" style="border-style:none;"/></a> </div> <div style="margin-bottom:10px;"> <a style="font-size: 110%; font-weight: bold;" href="https://www.tocris.com/products/eplerenone_2397" target="_blank" onClick="recordEvent(this, 'Supplier links', 'https://www.tocris.com/products/eplerenone_2397', 'Tocris Outbound Link 2397 Eplerenone');return false;">Eplerenone</a> <i>(links to external site)</i><br/> <i>Cat. No. 2397</i> </div> </td> </tr> </table> </div> </div> </div> <!-- ==================== GRID 16 END ==================== --> </div> <!-- BioSchemas Mark-Up For Ligands --> <script type="application/ld+json"> { "@context": "http://schema.org", "@id": "https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2876", "@type": "DataRecord", "dct:conformsTo": "https://bioschemas.org/profiles/MolecularEntity/0.5-RELEASE", "includedInDataset" : { "@type": "Dataset", "@id": "https://www.guidetopharmacology.org/index.jsp#dataset" }, "mainEntity": { "@id": "https://identifiers.org/iuphar.ligand:2876", "@type": "MolecularEntity", "name": "eplerenone", "alternateName": ["Inspra®","SC-66110"], "description": "Eplerenone is a potassium-sparing diuretic, which works by antagonising the effects of aldosterone.", "identifier": "2876", "inChI": "InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1", "inChIKey": "JUKPWJGBANNWMW-VWBFHTRKSA-N", "iupacName": "methyl (1'R,2R,2'S,9'R,10'R,11'S,15'S,17'R)-2',15'-dimethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo[8.8.0.0^{1,17}.0^{2,7}.0^{11,15}]octadecan]-6'-ene-9'-carboxylate", "molecularWeight": 414.2, "smiles": "COC(=O)C1CC2=CC(=O)CCC2(C23C1C1CCC4(C1(C)CC3O2)CCC(=O)O4)C", "url": "https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2876" } } </script> <script> // Popup Window var scrollTop = ''; 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