Regulation of RON-Receptor Tyrosine Kinase Functions by Epstein-Barr-Virus (EBV) Nuclear Antigen 3C

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publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Regulation of RON-Receptor Tyrosine Kinase Functions by Epstein-Barr-Virus (EBV) Nuclear Antigen 3C</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Roshika%20Tyagi">Roshika Tyagi</a>, <a href="https://publications.waset.org/abstracts/search?q=Shuvomoy%20Banerjee"> Shuvomoy Banerjee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Among various diseases, cancer has become a huge threat to human beings globally. In the context of viral infection, Epstein鈥揃arr virus (EBV) infection is ubiquitous in nature world-wide as well as in India. Recepteur d鈥橭rigine Nantais (RON) receptor tyrosine kinase is overexpressed in Lymphoblastoid cell lines (LCLs) but undetectable in primary B-cells. Biologically, RON expression was found to be essential for EBV transformed LCLs proliferation. In our study, we investigated whether EBV latent antigen EBNA3C is playing a crucial role in regulating RON receptor tyrosine kinase function in EBV-induced malignancies. Interestingly, we observed that expression pattern of RON was modulated by EBNA3C in EBV transformed LCLs compared with EBV negative BJAB cell line by PCR and western blot analysis. Moreover, in the absence of EBNA3C, RON expression was found low in western blot and immunofluorescence analysis and cell proliferation rate was significantly reduced in LCLs by cell viability assays. Therefore, our study clearly indicating the potential role of EBNA3C expressed in EBV-infected B-cells for modulating the functions of oncogenic kinases that leads to EBV induced B-cell transformation. <iframe src="https://publications.waset.org/abstracts/66176.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=apoptosis" title="apoptosis">apoptosis</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20proliferation" title=" cell proliferation"> cell proliferation</a>, <a href="https://publications.waset.org/abstracts/search?q=Epstein%E2%80%93barr%20virus" title=" Epstein鈥揵arr virus"> Epstein鈥揵arr virus</a>, <a href="https://publications.waset.org/abstracts/search?q=receptor%20tyrosine%20kinase" title=" receptor tyrosine kinase"> receptor tyrosine kinase</a> </p> <a href="https://publications.waset.org/abstracts/66176/regulation-of-ron-receptor-tyrosine-kinase-functions-by-epstein-barr-virus-ebv-nuclear-antigen-3c" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66176.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">229</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> 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Regulation of RON-Receptor Tyrosine Kinase Functions by Epstein-Barr-Virus (EBV) Nuclear Antigen 3C