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значајних жена\u003C/a\u003E\u003C/b\u003E на Викицитату.\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\n\u003Cdiv class=\"noticebanner\"\u003E\u003Cdiv class=\"plainlinks\" style=\"background-color: #FBEBEA; border-radius:5px; margin-top:10px; position:relative; border: 1px solid #aaa; font-family: \u0026#39;Helvetica\u0026#39;, \u0026#39;Arial\u0026#39;, sans-serif; line-height: 18px; box-shadow: 0 1px 1px rgba( 0, 0, 0, 0.15 ); overflow:hidden;\"\u003E\u003Cdiv style=\"display:block; top:4px; width:100%; text-align:center;;\"\u003E\u003Cdiv style=\"color:#000085; font-size:25px; line-height:25px\"\u003E\u003Cdiv style=\"padding-left:50px;\"\u003E\u003C/div\u003E\u003C/div\u003E\u003Cdiv style=\"padding-top:2px; color:#444; font-size:1.15em; line-height:1.5;\"\u003E\u003Cdiv style=\"padding-left:8px; padding-right:8px;\"\u003EПридружите се \u003Cb\u003E\u003Ca href=\"/wiki/%D0%92%D0%B8%D0%BA%D0%B8%D0%BF%D0%B5%D0%B4%D0%B8%D1%98%D0%B0:%D0%90%D0%BA%D1%86%D0%B8%D1%98%D0%B0_%D0%BF%D1%80%D0%BE%D1%88%D0%B8%D1%80%D0%B8%D0%B2%D0%B0%D1%9A%D0%B0_%D0%BA%D0%BB%D0%B8%D1%86%D0%B0\" title=\"Википедија:Акција проширивања клица\"\u003Eакцији проширивања клица\u003C/a\u003E\u003C/b\u003E.\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E\u003C/div\u003E";}}());</script></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Сајт"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Садржај" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" 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href="#Sinteza"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Sinteza</span> </div> </a> <ul id="toc-Sinteza-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Receptori" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Receptori"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Receptori</span> </div> </a> <ul id="toc-Receptori-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Značaj_i_funkcionisanje_kod_bolesti" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Značaj_i_funkcionisanje_kod_bolesti"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Značaj i funkcionisanje kod bolesti</span> </div> </a> <button aria-controls="toc-Značaj_i_funkcionisanje_kod_bolesti-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Садржај одељка Značaj i funkcionisanje kod bolesti</span> </button> <ul id="toc-Značaj_i_funkcionisanje_kod_bolesti-sublist" class="vector-toc-list"> <li id="toc-Odbrana_organizma_od_parazitskih_helminata" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Odbrana_organizma_od_parazitskih_helminata"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Odbrana organizma od parazitskih helminata</span> </div> </a> <ul id="toc-Odbrana_organizma_od_parazitskih_helminata-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Reakcija_rane_preosetljivosti" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Reakcija_rane_preosetljivosti"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Reakcija rane preosetljivosti</span> </div> </a> <ul id="toc-Reakcija_rane_preosetljivosti-sublist" class="vector-toc-list"> <li id="toc-Procesi_u_reakciji_rane_preosetljivosti" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Procesi_u_reakciji_rane_preosetljivosti"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2.1</span> <span>Procesi u reakciji rane preosetljivosti</span> </div> </a> <ul id="toc-Procesi_u_reakciji_rane_preosetljivosti-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-Reference" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Reference"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Reference</span> </div> </a> <ul id="toc-Reference-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Literatura" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Literatura"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Literatura</span> </div> </a> <ul id="toc-Literatura-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Spoljašnje_veze" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Spoljašnje_veze"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Spoljašnje veze</span> </div> </a> <ul id="toc-Spoljašnje_veze-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Садржај" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Прикажи/сакриј садржај" > <label 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Доступан на: 27" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-27" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">27 језика</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%BA%D9%84%D9%88%D8%A8%D9%8A%D9%88%D9%84%D9%8A%D9%86_%D9%85%D9%86%D8%A7%D8%B9%D9%8A_%D9%87%D9%80" title="غلوبيولين مناعي هـ — арапски" lang="ar" hreflang="ar" data-title="غلوبيولين مناعي هـ" data-language-autonym="العربية" data-language-local-name="арапски" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Antibodi_E" title="Antibodi E — индонежански" lang="id" hreflang="id" data-title="Antibodi E" data-language-autonym="Bahasa Indonesia" data-language-local-name="индонежански" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Immunoglobulina_E" title="Immunoglobulina E — каталонски" lang="ca" hreflang="ca" data-title="Immunoglobulina E" data-language-autonym="Català" data-language-local-name="каталонски" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Imunoglobulin_E" title="Imunoglobulin E — чешки" lang="cs" hreflang="cs" data-title="Imunoglobulin E" data-language-autonym="Čeština" data-language-local-name="чешки" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Immunoglobulin_E" title="Immunoglobulin E — дански" lang="da" hreflang="da" data-title="Immunoglobulin E" data-language-autonym="Dansk" data-language-local-name="дански" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Immunglobulin_E" title="Immunglobulin E — немачки" lang="de" hreflang="de" data-title="Immunglobulin E" data-language-autonym="Deutsch" data-language-local-name="немачки" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%91%CE%BD%CE%BF%CF%83%CE%BF%CF%83%CF%86%CE%B1%CE%B9%CF%81%CE%AF%CE%BD%CE%B7_%CE%95" title="Ανοσοσφαιρίνη Ε — грчки" lang="el" hreflang="el" data-title="Ανοσοσφαιρίνη Ε" data-language-autonym="Ελληνικά" data-language-local-name="грчки" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Immunoglobulin_E" title="Immunoglobulin E — енглески" lang="en" hreflang="en" data-title="Immunoglobulin E" data-language-autonym="English" data-language-local-name="енглески" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Inmunoglobulina_E" title="Inmunoglobulina E — шпански" lang="es" hreflang="es" data-title="Inmunoglobulina E" data-language-autonym="Español" data-language-local-name="шпански" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/E_immunoglobulina" title="E immunoglobulina — баскијски" lang="eu" hreflang="eu" data-title="E immunoglobulina" data-language-autonym="Euskara" data-language-local-name="баскијски" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A7%DB%8C%D9%85%D9%88%D9%86%D9%88%DA%AF%D9%84%D9%88%D8%A8%D9%88%D9%84%DB%8C%D9%86_%D8%A6%DB%8C" title="ایمونوگلوبولین ئی — персијски" lang="fa" hreflang="fa" data-title="ایمونوگلوبولین ئی" data-language-autonym="فارسی" data-language-local-name="персијски" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Immunoglobuline_E" title="Immunoglobuline E — француски" lang="fr" hreflang="fr" data-title="Immunoglobuline E" data-language-autonym="Français" data-language-local-name="француски" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Inmunoglobulina_E" title="Inmunoglobulina E — галицијски" lang="gl" hreflang="gl" data-title="Inmunoglobulina E" data-language-autonym="Galego" data-language-local-name="галицијски" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/IgE" title="IgE — италијански" lang="it" hreflang="it" data-title="IgE" data-language-autonym="Italiano" data-language-local-name="италијански" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E5%85%8D%E7%96%AB%E3%82%B0%E3%83%AD%E3%83%96%E3%83%AA%E3%83%B3E" title="免疫グロブリンE — јапански" lang="ja" hreflang="ja" data-title="免疫グロブリンE" data-language-autonym="日本語" data-language-local-name="јапански" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%98%D0%B3%D0%B5" title="Иге — казашки" lang="kk" hreflang="kk" data-title="Иге" data-language-autonym="Қазақша" data-language-local-name="казашки" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%A9%B4%EC%97%AD%EA%B8%80%EB%A1%9C%EB%B6%88%EB%A6%B0_E" title="면역글로불린 E — корејски" lang="ko" hreflang="ko" data-title="면역글로불린 E" data-language-autonym="한국어" data-language-local-name="корејски" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%87%E0%B4%AE%E0%B5%8D%E0%B4%AE%E0%B5%8D%E0%B4%AF%E0%B5%82%E0%B4%A3%E0%B5%8B%E0%B4%97%E0%B5%8D%E0%B4%B2%E0%B5%8B%E0%B4%AC%E0%B5%81%E0%B4%B2%E0%B4%BF%E0%B5%BB_%E0%B4%87" title="ഇമ്മ്യൂണോഗ്ലോബുലിൻ ഇ — малајалам" lang="ml" hreflang="ml" data-title="ഇമ്മ്യൂണോഗ്ലോബുലിൻ ഇ" data-language-autonym="മലയാളം" data-language-local-name="малајалам" class="interlanguage-link-target"><span>മലയാളം</span></a></li><li class="interlanguage-link interwiki-uz mw-list-item"><a href="https://uz.wikipedia.org/wiki/Immunoglobulin_E" title="Immunoglobulin E — узбечки" lang="uz" hreflang="uz" data-title="Immunoglobulin E" data-language-autonym="Oʻzbekcha / ўзбекча" data-language-local-name="узбечки" class="interlanguage-link-target"><span>Oʻzbekcha / ўзбекча</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Immunoglobuliny_E" title="Immunoglobuliny E — пољски" lang="pl" hreflang="pl" data-title="Immunoglobuliny E" data-language-autonym="Polski" data-language-local-name="пољски" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Imunoglobulina_E" title="Imunoglobulina E — португалски" lang="pt" hreflang="pt" data-title="Imunoglobulina E" data-language-autonym="Português" data-language-local-name="португалски" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru badge-Q17559452 badge-recommendedarticle mw-list-item" title="препоручен чланак"><a href="https://ru.wikipedia.org/wiki/%D0%98%D0%BC%D0%BC%D1%83%D0%BD%D0%BE%D0%B3%D0%BB%D0%BE%D0%B1%D1%83%D0%BB%D0%B8%D0%BD%D1%8B_E" title="Иммуноглобулины E — руски" lang="ru" hreflang="ru" data-title="Иммуноглобулины E" data-language-autonym="Русский" data-language-local-name="руски" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Immunoglobuliini_E" title="Immunoglobuliini E — фински" lang="fi" hreflang="fi" data-title="Immunoglobuliini E" data-language-autonym="Suomi" data-language-local-name="фински" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Immunglobulin_E" title="Immunglobulin E — шведски" lang="sv" hreflang="sv" data-title="Immunglobulin E" data-language-autonym="Svenska" data-language-local-name="шведски" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Globulin_mi%E1%BB%85n_d%E1%BB%8Bch_E" title="Globulin miễn dịch E — вијетнамски" lang="vi" hreflang="vi" data-title="Globulin miễn dịch E" data-language-autonym="Tiếng Việt" data-language-local-name="вијетнамски" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%86%D0%BC%D1%83%D0%BD%D0%BE%D0%B3%D0%BB%D0%BE%D0%B1%D1%83%D0%BB%D1%96%D0%BD_E" title="Імуноглобулін E — украјински" lang="uk" hreflang="uk" data-title="Імуноглобулін E" data-language-autonym="Українська" data-language-local-name="украјински" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%85%8D%E7%96%AB%E7%90%83%E8%9B%8B%E7%99%BDE" title="免疫球蛋白E — кинески" lang="zh" hreflang="zh" data-title="免疫球蛋白E" data-language-autonym="中文" data-language-local-name="кинески" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q79455#sitelinks-wikipedia" title="Уреди међујезичке везе" class="wbc-editpage">Уреди везе</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Именски простори"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet 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vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Изглед</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">помери на страну</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">сакриј</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">С Википедије, слободне енциклопедије</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="sr" dir="ltr"><figure typeof="mw:File/Thumb"><a href="/wiki/%D0%94%D0%B0%D1%82%D0%BE%D1%82%D0%B5%D0%BA%D0%B0:Imunoglobulin_E_struktura.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/85/Imunoglobulin_E_struktura.png/422px-Imunoglobulin_E_struktura.png" decoding="async" width="422" height="187" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/85/Imunoglobulin_E_struktura.png/633px-Imunoglobulin_E_struktura.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/85/Imunoglobulin_E_struktura.png/844px-Imunoglobulin_E_struktura.png 2x" data-file-width="899" data-file-height="398" /></a><figcaption>Imunoglobulin E struktura</figcaption></figure> <p><b>Imunoglobulin E</b> (<b>IgE</b>) je tip <a href="/wiki/%D0%90%D0%BD%D1%82%D0%B8%D1%82%D0%B5%D0%BB%D0%BE" title="Антитело">antitela</a> (imunoglobulinski izotip), koji je pronađen samo kod sisara. Prvi dokaz o prisustvu supstance koja je odgovorna za reakcije preosetljivosti datira iz 1921. godine, a 1967. godine, istraživanje Išizake i saradnika je utvrdilo da se radi o novoj klasi <a href="/wiki/%D0%90%D0%BD%D1%82%D0%B8%D1%82%D0%B5%D0%BB%D0%BE" title="Антитело">imunoglobulina</a>, tj. o IgE. </p><p>IgE sintetišu <a href="/wiki/%D0%9F%D0%BB%D0%B0%D0%B7%D0%BC%D0%BE%D1%86%D0%B8%D1%82" title="Плазмоцит">plazmociti</a>, locirani u <a href="/wiki/%D0%9B%D0%B8%D0%BC%D1%84%D0%BD%D0%B8_%D1%87%D0%B2%D0%BE%D1%80%D0%BE%D0%B2%D0%B8" title="Лимфни чворови">limfnim čvorovima</a>. Kao i ostali <a href="/wiki/%D0%90%D0%BD%D1%82%D0%B8%D1%82%D0%B5%D0%BB%D0%BE" title="Антитело">imunoglobulini</a>, IgE je izgrađen od 4 polipeptidna lanca (dva teška ɛ lanca i dva laka κ/λ lanca). Karakterističan je po svom ɛ lancu, koji je sačinjen od 4 konstantna (C) domena (Cε1-Cε4).<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> IgE molekul je izraženo <a href="/wiki/Glikozilacija" title="Glikozilacija">glikozilovan</a>. Sadržaj ugljenih hidrata čini 13% ukupne mase molekula. </p><p>IgE antitela aktiviraju reakcije posredovane <a href="/wiki/%D0%9C%D0%B0%D1%81%D1%82%D0%BE%D1%86%D0%B8%D1%82" title="Мастоцит">mastocitima</a> i <a href="/wiki/Eozinofilni_granulocit" class="mw-redirect" title="Eozinofilni granulocit">eozinofilima</a>, obezbeđujući odbranu organizma od parazita, a posebno od parazitskih helminata,<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> poput <i><a href="/wiki/Schistosoma_mansoni" title="Schistosoma mansoni">Schistosoma mansoni</a></i>, <i><a href="/w/index.php?title=Trichinella_spiralis&action=edit&redlink=1" class="new" title="Trichinella spiralis (страница не постоји)">Trichinella spiralis</a></i>, i <i><a href="/w/index.php?title=Fasciola_hepatica&action=edit&redlink=1" class="new" title="Fasciola hepatica (страница не постоји)">Fasciola hepatica</a></i>,<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> gde predstavljaju <a href="/w/index.php?title=Humoralni_imunski_odgovor&action=edit&redlink=1" class="new" title="Humoralni imunski odgovor (страница не постоји)">humoralni imunski odgovor</a> organizma. Ubijanje helminata je posredovano IgE i eozinofilima. IgE se koristi tokom imunske odbrane protiv pojedinih <a href="/wiki/Protozoa" class="mw-redirect" title="Protozoa">protozoanskih</a> <a href="/wiki/%D0%9F%D0%B0%D1%80%D0%B0%D0%B7%D0%B8%D1%82" class="mw-redirect" title="Паразит">parazita</a>, kao što je <i><a href="/w/index.php?title=Plasmodium_falciparum&action=edit&redlink=1" class="new" title="Plasmodium falciparum (страница не постоји)">Plasmodium falciparum</a></i>.<sup id="cite_ref-duarte_6-0" class="reference"><a href="#cite_note-duarte-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>Takođe, IgE učestvuje u <a href="/wiki/%D0%90%D0%BB%D0%B5%D1%80%D0%B3%D0%B8%D1%98%D1%81%D0%BA%D0%B0_%D1%80%D0%B5%D0%B0%D0%BA%D1%86%D0%B8%D1%98%D0%B0" title="Алергијска реакција">alergijskim reakcijama</a>. Odgovoran je, uz mastocite, za reakciju rane preosetljivosti. Mastociti senzibilisani IgE, pri izlaganju alergenu, luče karakteristične medijatore, koji imaju različita dejstva. Najčešći tipovi alergija su: polenska groznica, alergije na hranu, bronhijalna astma, dok <a href="/wiki/%D0%90%D0%BD%D0%B0%D1%84%D0%B8%D0%BB%D0%B0%D0%BA%D1%82%D0%B8%D1%87%D0%BD%D0%B8_%D1%88%D0%BE%D0%BA" title="Анафилактични шок">anafilaksija</a> predstavlja najteži oblik rane preosetljivosti. </p><p>U fiziološkim uslovima, IgE je najmanje zastupljen imunoglobulinski izotip. Koncentracija u krvnoj plazmi normalno iznosi manje od 1 µg/ml. Poluživot IgE u serumu je oko 2 dana. </p><p>Osim kod parazitskih infekcija i alergijskih reakcija, povišene vrednosti IgE se javljaju i kod nekih drugih oboljenja, kao što su <a href="/w/index.php?title=IgE_mijelom&action=edit&redlink=1" class="new" title="IgE mijelom (страница не постоји)">IgE mijelom</a>, <a href="/w/index.php?title=Hiper_IgE_sindrom&action=edit&redlink=1" class="new" title="Hiper IgE sindrom (страница не постоји)">hiper IgE sindrom</a>. <sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> <sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Sinteza">Sinteza</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Imunoglobulin_E&veaction=edit&section=1" title="Уредите одељак „Sinteza”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Imunoglobulin_E&action=edit&section=1" title="Уреди извор одељка: Sinteza"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Sinteza IgE se odvija po principu promene klase teških lanaca. Potomački <a href="/wiki/%D0%91-%D0%BB%D0%B8%D0%BC%D1%84%D0%BE%D1%86%D0%B8%D1%82%D0%B8" class="mw-redirect" title="Б-лимфоцити">B-limfociti</a> prvobitno sintetišu <a href="/w/index.php?title=IgM&action=edit&redlink=1" class="new" title="IgM (страница не постоји)">IgM</a> i <a href="/w/index.php?title=IgD&action=edit&redlink=1" class="new" title="IgD (страница не постоји)">IgD</a>, ali <a href="/wiki/Th2_%C4%87elija" class="mw-redirect" title="Th2 ćelija">pomoćne T-ćelije</a> mogu stimulisati sintezu <a href="/wiki/%D0%90%D0%BD%D1%82%D0%B8%D1%82%D0%B5%D0%BB%D0%BE" title="Антитело">antitela</a> različitih klasa teških lanaca. Vezivanje antigena za antitelo na membrani izaziva internalizaciju i proteolitičko razlaganje antigena do peptida, koji se vezuju za <a href="/w/index.php?title=MHC&action=edit&redlink=1" class="new" title="MHC (страница не постоји)">MHC</a> molekule klase 2 i prikazuju na površini ćelije, kako bi bili prezentovani pomoćnim T-ćelijama. Pomoćne T-ćelije, direktno i preko <a href="/wiki/%D0%A6%D0%B8%D1%82%D0%BE%D0%BA%D0%B8%D0%BD%D0%B8" class="mw-redirect" title="Цитокини">citokina</a>, pružaju signale B-limfocitima, koji određuju promenu klase antitela. </p><p>U slučaju Ige, <a href="/wiki/CD154" title="CD154">CD154 (CD40L)</a>, prolazno eksprimiran na aktiviranim T-ćelijama, aktivira <a href="/w/index.php?title=NF-%CE%BAB_signalni_put&action=edit&redlink=1" class="new" title="NF-κB signalni put (страница не постоји)">NF-κB signalni put</a> preko konstitutivno eksprimiranog <a href="/w/index.php?title=CD40&action=edit&redlink=1" class="new" title="CD40 (страница не постоји)">CD40</a> na B-ćeliji. Kada je CD40 stimulus praćen <a href="/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD_4" title="Интерлеукин 4">IL-4</a> signalom, postupak promene klase je aktivan i usmeren ka sintezi IgE. <sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Receptori">Receptori</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Imunoglobulin_E&veaction=edit&section=2" title="Уредите одељак „Receptori”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Imunoglobulin_E&action=edit&section=2" title="Уреди извор одељка: Receptori"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/w/index.php?title=Receptori_za_IgE&action=edit&redlink=1" class="new" title="Receptori za IgE (страница не постоји)">Receptori za IgE</a> se nazivaju Fc receptori, a podeljeni su na 2 tipa: </p> <ul><li>FcεRI (Fcε receptor tipa 1) - receptor visokog afiniteta za IgE</li> <li>CD23 (Fcε receptor tipa 2) - receptor niskog afiniteta za IgE</li></ul> <p><a href="/w/index.php?title=Fc%CE%B5RI_receptor&action=edit&redlink=1" class="new" title="FcεRI receptor (страница не постоји)">FcεRI receptor</a> se u velikom broju nalazi na membranama <a href="/wiki/%D0%9C%D0%B0%D1%81%D1%82%D0%BE%D1%86%D0%B8%D1%82" title="Мастоцит">mastocita</a> i <a href="/w/index.php?title=Bazofilni_granulocit&action=edit&redlink=1" class="new" title="Bazofilni granulocit (страница не постоји)">bazofila</a> u obliku tetramera αβγ2 (oblik odgovoran za reakciju rane preosetljivosti, uloga u <a href="/w/index.php?title=Degranulacija&action=edit&redlink=1" class="new" title="Degranulacija (страница не постоји)">degranulaciji</a> mastocita). Na ćelijama, kao što su <a href="/wiki/Eozinofilni_granulocit" class="mw-redirect" title="Eozinofilni granulocit">eozinofili</a>, bazofili, <a href="/wiki/%D0%A2%D1%80%D0%BE%D0%BC%D0%B1%D0%BE%D1%86%D0%B8%D1%82" class="mw-redirect" title="Тромбоцит">trombociti</a> i <a href="/wiki/%D0%94%D0%B5%D0%BD%D0%B4%D1%80%D0%B8%D1%82%D1%81%D0%BA%D0%B0_%D1%9B%D0%B5%D0%BB%D0%B8%D1%98%D0%B0" title="Дендритска ћелија">dendritske ćelije</a>, nalazi se u trimernom αγ2 obliku. Monomerni IgE se za ovaj tip receptora vezuje sa visokim afinitetom (Kd ~ 1nm), tako da to, i prilikom fizioloških koncentracija IgE, za posledicu ima potpunu saturaciju receptora. </p><p><a href="/w/index.php?title=CD23_receptor&action=edit&redlink=1" class="new" title="CD23 receptor (страница не постоји)">CD23 receptor</a> je <a href="/wiki/Integralni_membranski_protein" title="Integralni membranski protein">integralni membranski protein</a> tipa 2 i sadrži lektinski domen C tipa na c-terminalnom kraju vanćelijske komponente receptora. Njegovu ekspresiju stimuliše <a href="/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD_4" title="Интерлеукин 4">interleukin 4</a> (IL-4). Postoje dve izoforme ovog tipa receptora. Izoforma CD23a se nalazi isključivo na <a href="/wiki/%D0%91-%D0%BB%D0%B8%D0%BC%D1%84%D0%BE%D1%86%D0%B8%D1%82" class="mw-redirect" title="Б-лимфоцит">B-limfocitima</a>, dok se izoforma CD23b nalazi kod mnogih ćelija, kao što su <a href="/wiki/T-limfocit" class="mw-redirect" title="T-limfocit">T-limfociti</a>, <a href="/wiki/Neutrofilni_granulocit" class="mw-redirect" title="Neutrofilni granulocit">neutrofili</a>, <a href="/wiki/%D0%9C%D0%BE%D0%BD%D0%BE%D1%86%D0%B8%D1%82%D0%B8" title="Моноцити">monociti</a>, dendritske ćelije... IgE se za CD23 receptor vezuje sa niskim afinitetom (Kd 0.1–1µM), što ukazuje da je moguće da IgE nije primarni <a href="/wiki/Ligand_(biohemija)" title="Ligand (biohemija)">ligand</a> za ovaj receptor. Vezivane IgE za CD23 receptor deluje kao <a href="/wiki/Negativna_povratna_sprega" class="mw-redirect" title="Negativna povratna sprega">negativna povratna sprega</a> na B-limfocite, smanjujući sintezu IgE. </p> <div class="mw-heading mw-heading2"><h2 id="Značaj_i_funkcionisanje_kod_bolesti"><span id="Zna.C4.8Daj_i_funkcionisanje_kod_bolesti"></span>Značaj i funkcionisanje kod bolesti</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Imunoglobulin_E&veaction=edit&section=3" title="Уредите одељак „Značaj i funkcionisanje kod bolesti”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Imunoglobulin_E&action=edit&section=3" title="Уреди извор одељка: Značaj i funkcionisanje kod bolesti"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Imunoglobulin E aktivira reakcije posredovane <a href="/wiki/%D0%9C%D0%B0%D1%81%D1%82%D0%BE%D1%86%D0%B8%D1%82" title="Мастоцит">mastocitima</a> i <a href="/wiki/Eozinofilni_granulocit" class="mw-redirect" title="Eozinofilni granulocit">eozinofilima</a> koje imaju ulogu u odbrani organizma od parazitskih helminata. Takođe, IgE učestvuje i u alergijskim reakcijama (reakcijama rane preosetljivosti). </p><p>Sa evolutivnog aspekta, i dalje je nejasno zašto je sačuvan imunski odgovor posredovan IgE antitelima i mastocitima, čiji su glavni efekti patološki. Smatra se da su reakcije rane preosetljivosti najverovatnije nastale kako bi pružale zaštitu od patogena i toksina. </p> <div class="mw-heading mw-heading3"><h3 id="Odbrana_organizma_od_parazitskih_helminata">Odbrana organizma od parazitskih helminata</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Imunoglobulin_E&veaction=edit&section=4" title="Уредите одељак „Odbrana organizma od parazitskih helminata”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Imunoglobulin_E&action=edit&section=4" title="Уреди извор одељка: Odbrana organizma od parazitskih helminata"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Većina <a href="/w/index.php?title=Helminti&action=edit&redlink=1" class="new" title="Helminti (страница не постоји)">helminata</a> je velika i obložena debelim omotačem, što onemogućava <a href="/wiki/%D0%A4%D0%B0%D0%B3%D0%BE%D1%86%D0%B8%D1%82%D0%BE%D0%B7%D0%B0" title="Фагоцитоза">fagocitozu</a> i povećava njihovu otpornost na <a href="/w/index.php?title=Mikrobicid&action=edit&redlink=1" class="new" title="Mikrobicid (страница не постоји)">mikrobicidne</a> supstance koje luče <a href="/wiki/Neutrofilni_granulocit" class="mw-redirect" title="Neutrofilni granulocit">neutrofili</a> i <a href="/wiki/%D0%9C%D0%B0%D0%BA%D1%80%D0%BE%D1%84%D0%B0%D0%B3" title="Макрофаг">makrofagi</a>. <a href="/w/index.php?title=Humoralni_imuni_odgovor&action=edit&redlink=1" class="new" title="Humoralni imuni odgovor (страница не постоји)">Humoralni imuni odgovor</a> se zasniva na IgE antitelima. IgE se vezuje za helminte i pospešuje vezivanje <a href="/wiki/Eozinofilni_granulocit" class="mw-redirect" title="Eozinofilni granulocit">eozinofila</a> zahvaljujući Fc receptoru visokog afiniteta (FcεRI), eksprimiranog na eozinofilima i mastocitima. </p><p>Angažovanje FcεRI, uz <a href="/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD_5" title="Интерлеукин 5">interleukin-5</a> (IL-5), koji je produkt aktivnosti <a href="/wiki/T_pomo%C4%87ne_%C4%87elije" title="T pomoćne ćelije">Th2 pomoćnih ćelija</a>, aktivira degranulaciju eozinofila, a samim tim i oslobađanje toksičnih medijatora koji mogu da ubiju helminte. </p><p>IgE se vezuje za <a href="/wiki/%D0%9C%D0%B0%D1%81%D1%82%D0%BE%D1%86%D0%B8%D1%82" title="Мастоцит">mastocite</a>, aktivirajući oslobađanje <a href="/wiki/Hemokini" title="Hemokini">hemokina</a>, koji imaju ulogu da privuku veliki broj <a href="/wiki/%D0%9B%D0%B5%D1%83%D0%BA%D0%BE%D1%86%D0%B8%D1%82" class="mw-redirect" title="Леукоцит">leukocita</a>, kako bi se olakšalo uništavanje helminata. </p> <div class="mw-heading mw-heading3"><h3 id="Reakcija_rane_preosetljivosti">Reakcija rane preosetljivosti</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Imunoglobulin_E&veaction=edit&section=5" title="Уредите одељак „Reakcija rane preosetljivosti”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Imunoglobulin_E&action=edit&section=5" title="Уреди извор одељка: Reakcija rane preosetljivosti"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Rana preosetljivost je posredovana IgE antitelima i <a href="/wiki/%D0%9C%D0%B0%D1%81%D1%82%D0%BE%D1%86%D0%B8%D1%82" title="Мастоцит">mastocitima</a>, a predstavlja reakciju organizma na prisustvo određenih <a href="/wiki/%D0%90%D0%BD%D1%82%D0%B8%D0%B3%D0%B5%D0%BD" title="Антиген">antigena</a>. Karakteriše se brzim izlaskom tečnosti iz krvnih sudova, sekrecijom mukusa, a često je praćena i zapaljenjem. </p><p>Poremećaji u kojima je rana preosetljivost posredovana IgE antitelima izražena, nazivaju se alergije ili atopije. </p><p>Nastanak reakcije rane preosetljivosti započinje aktivacijom <a href="/wiki/T_pomo%C4%87ne_%C4%87elije" title="T pomoćne ćelije">Th2 pomoćnih ćelija</a> i <a href="/w/index.php?title=Folikularne_pomo%C4%87ne_T-%C4%87elije&action=edit&redlink=1" class="new" title="Folikularne pomoćne T-ćelije (страница не постоји)">folikularnih pomoćnih T-ćelija</a> (Tfh), koje luče interleukin 4. Ovi procesi stimulišu nastanak IgE antitela u odgovoru na antigen, kao i vezivanje nastalog IgE za <a href="/w/index.php?title=Fc_receptori&action=edit&redlink=1" class="new" title="Fc receptori (страница не постоји)">Fc receptore</a> mastocita. Pri naknadnom izlaganju istom antigenu dolazi do unakrsnog povezivanja IgE tim antigenom i oslobađanja medijatora iz mastocita. Neki medijatori izazivaju brzo povećanje propustljivosti krvnih sudova i kontrakciju glatkih mišića. Takva reakcija se može javiti u roku od nekoliko minuta nakon što senzibilisana osoba ponovo unese antigen. </p> <figure typeof="mw:File/Thumb"><a href="/wiki/%D0%94%D0%B0%D1%82%D0%BE%D1%82%D0%B5%D0%BA%D0%B0:Degranulacija_1_-_antigen;_2_-_IgE;_3_-_Fc%CE%B5RI_receptor;_4_-_medijatori_(histamin,_proteaze,_hemokini,_heparin);_5_-_granule;_6_-_mastocit;_7_-_novoformirani_medijatori_(prostaglandini,_leukotrieni).png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/71/Degranulacija_1_-_antigen%3B_2_-_IgE%3B_3_-_Fc%CE%B5RI_receptor%3B_4_-_medijatori_%28histamin%2C_proteaze%2C_hemokini%2C_heparin%29%3B_5_-_granule%3B_6_-_mastocit%3B_7_-_novoformirani_medijatori_%28prostaglandini%2C_leukotrieni%29.png/280px-thumbnail.png" decoding="async" width="280" height="210" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/71/Degranulacija_1_-_antigen%3B_2_-_IgE%3B_3_-_Fc%CE%B5RI_receptor%3B_4_-_medijatori_%28histamin%2C_proteaze%2C_hemokini%2C_heparin%29%3B_5_-_granule%3B_6_-_mastocit%3B_7_-_novoformirani_medijatori_%28prostaglandini%2C_leukotrieni%29.png/420px-thumbnail.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/71/Degranulacija_1_-_antigen%3B_2_-_IgE%3B_3_-_Fc%CE%B5RI_receptor%3B_4_-_medijatori_%28histamin%2C_proteaze%2C_hemokini%2C_heparin%29%3B_5_-_granule%3B_6_-_mastocit%3B_7_-_novoformirani_medijatori_%28prostaglandini%2C_leukotrieni%29.png/560px-thumbnail.png 2x" data-file-width="800" data-file-height="600" /></a><figcaption>Degranulacija, 1 - antigen; 2 - IgE; 3 - FcεRI receptor; 4 - medijatori (histamin, proteaze, hemokini, heparin); 5 - granule; 6 - mastocit; 7 - novoformirani medijatori (prostaglandini, leukotrieni)</figcaption></figure> <div class="mw-heading mw-heading4"><h4 id="Procesi_u_reakciji_rane_preosetljivosti">Procesi u reakciji rane preosetljivosti</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Imunoglobulin_E&veaction=edit&section=6" title="Уредите одељак „Procesi u reakciji rane preosetljivosti”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Imunoglobulin_E&action=edit&section=6" title="Уреди извор одељка: Procesi u reakciji rane preosetljivosti"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Antigenom aktivirane Th2 ili Tfh ćelije luče <a href="/wiki/%D0%A6%D0%B8%D1%82%D0%BE%D0%BA%D0%B8%D0%BD%D0%B8" class="mw-redirect" title="Цитокини">citokine</a> <a href="/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD_4" title="Интерлеукин 4">IL-4</a> i <a href="/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD_13" title="Интерлеукин 13">IL-13</a>. Navedeni citokini stimulišu <a href="/wiki/%D0%91-%D0%BB%D0%B8%D0%BC%D1%84%D0%BE%D1%86%D0%B8%D1%82%D0%B8" class="mw-redirect" title="Б-лимфоцити">B-limfocite</a> da se diferenciraju u <a href="/wiki/%D0%9F%D0%BB%D0%B0%D0%B7%D0%BC%D0%BE%D1%86%D0%B8%D1%82" title="Плазмоцит">plazmocite</a>, koji su odgovorni za produkciju IgE. Usled toga se kod alergičnih osoba stvaraju velike količine IgE prilikom odgovora na antigene, koji kod ostalih ljudi ne bi izazvali IgE odgovor. </p><p>Nastala IgE antitela se na mastocitima vezuju za FcεRI receptore. Kod alergičnih osoba, mastociti su obloženi specifičnim IgE antitelima za neki <a href="/wiki/%D0%90%D0%BD%D1%82%D0%B8%D0%B3%D0%B5%D0%BD" title="Антиген">antigen</a>. Oblaganje <a href="/wiki/%D0%9C%D0%B0%D1%81%D1%82%D0%BE%D1%86%D0%B8%D1%82" title="Мастоцит">mastocita</a> IgE <a href="/wiki/%D0%90%D0%BD%D1%82%D0%B8%D1%82%D0%B5%D0%BB%D0%BE" title="Антитело">antitelima</a> se naziva <a href="/w/index.php?title=Senzibilizacija&action=edit&redlink=1" class="new" title="Senzibilizacija (страница не постоји)">senzibilizacija</a>, jer oblaganje IgE antitelima specifičnim za antigen čini mastocite osetljivim na aktivaciju pri narednom kontaktu sa istim tim antigenom. Kod ostalih osoba, mastociti su obično obloženi IgE antitelima različitih specifičnosti, pa je u tom slučaju broj specifičnih IgE antitela nedovoljan da izazove reakciju rane preosetljivosti pri izlaganju nekom antigenu. </p><p>Do aktivacije mastocita dolazi usled vezivanja antigena za dva ili više molekula IgE na ćeliji. Taj događaj dovodi do unakrsnog povezivanja FcεRI molekula koji nose IgE i sprovođenja biohemijskih signala. Takvi signali dovode do <a href="/w/index.php?title=Degranulacija&action=edit&redlink=1" class="new" title="Degranulacija (страница не постоји)">degranulacije</a> mastocita, sinteze i oslobađanja lipidnih medijatora, kao i <a href="/wiki/%D0%A6%D0%B8%D1%82%D0%BE%D0%BA%D0%B8%D0%BD%D0%B8" class="mw-redirect" title="Цитокини">citokina</a>. <sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Reference">Reference</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Imunoglobulin_E&veaction=edit&section=7" title="Уредите одељак „Reference”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Imunoglobulin_E&action=edit&section=7" title="Уреди извор одељка: Reference"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r28440201">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 30em;"> <ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><cite class="citation web"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20080906211232/http://www.cartage.org.lb/en/themes/Sciences/LifeScience/GeneralBiology/Immunology/Recognition/AntigenRecognition/Antibodystructure/Antibodystructure.htm">„Antibody structure”</a>. Архивирано из <a rel="nofollow" class="external text" href="http://www.cartage.org.lb/en/themes/Sciences/LifeScience/GeneralBiology/Immunology/Recognition/AntigenRecognition/Antibodystructure/Antibodystructure.htm">оригинала</a> 6. 9. 2008. г.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AImunoglobulin+E&rft.btitle=Antibody+structure&rft.genre=unknown&rft_id=http%3A%2F%2Fwww.cartage.org.lb%2Fen%2Fthemes%2FSciences%2FLifeScience%2FGeneralBiology%2FImmunology%2FRecognition%2FAntigenRecognition%2FAntibodystructure%2FAntibodystructure.htm&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><cite class="citation journal">Erb KJ (2007). „Helminths, allergic disorders and IgE-mediated immune responses: where do we stand?”. <i>Eur. J. 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Allergy Immunol</i>. <b>142</b> (1): 40—50. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/17019080">17019080</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1159%2F000095997">10.1159/000095997</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AImunoglobulin+E&rft.atitle=Factors+affecting+human+IgE+and+IgG+responses+to+allergen-like+Schistosoma+mansoni+antigens%3A+Molecular+structure+and+patterns+of+in+vivo+exposure&rft.au=Dunne%2C+DW&rft.au=Hoffmann%2C+KF&rft.au=Jones%2C+FM&rft.au=Joseph%2C+S&rft.au=Kabatereine%2C+NB&rft.au=Kariuki%2C+HC&rft.au=Kimani%2C+G&rft.au=McBeath%2C+R&rft.au=Mwatha%2C+JK&rft.au=Ouma%2C+JH&rft.au=Vennervald%2C+BJ&rft.au=Walter%2C+K&rft.aufirst=CM&rft.aulast=Fitzsimmons&rft.date=2007&rft.genre=article&rft.issue=1&rft.jtitle=Int.+Arch.+Allergy+Immunol.&rft.pages=40-50&rft.volume=142&rft_id=info%3Adoi%2F10.1159%2F000095997&rft_id=info%3Apmid%2F17019080&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><cite class="citation journal">Watanabe N, Bruschi F, Korenaga M (2005). <a rel="nofollow" class="external text" href="https://archive.org/details/sim_trends-in-parasitology_2005-04_21_4/page/175">„IgE: a question of protective immunity in Trichinella spiralis infection”</a>. <i>Trends Parasitol</i>. <b>21</b> (4): 175—8. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/15780839">15780839</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.pt.2005.02.010">10.1016/j.pt.2005.02.010</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AImunoglobulin+E&rft.atitle=IgE%3A+a+question+of+protective+immunity+in+Trichinella+spiralis+infection&rft.au=Bruschi%2C+F&rft.au=Korenaga%2C+M&rft.aufirst=N&rft.aulast=Watanabe&rft.date=2005&rft.genre=article&rft.issue=4&rft.jtitle=Trends+Parasitol.&rft.pages=175-8&rft.volume=21&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_trends-in-parasitology_2005-04_21_4%2Fpage%2F175&rft_id=info%3Adoi%2F10.1016%2Fj.pt.2005.02.010&rft_id=info%3Apmid%2F15780839&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><cite class="citation journal">Pfister K, Turner K, Currie A, Hall E, Jarrett EE (1983). <a rel="nofollow" class="external text" href="https://archive.org/details/sim_parasite-immunology_1983-11_5_6/page/587">„IgE production in rat fascioliasis”</a>. <i>Parasite Immunol</i>. <b>5</b> (6): 587—93. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/6657297">6657297</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1365-3024.1983.tb00775.x">10.1111/j.1365-3024.1983.tb00775.x</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AImunoglobulin+E&rft.atitle=IgE+production+in+rat+fascioliasis&rft.au=Currie%2C+A&rft.au=Hall%2C+E&rft.au=Jarrett%2C+EE&rft.au=Turner%2C+K&rft.aufirst=K&rft.aulast=Pfister&rft.date=1983&rft.genre=article&rft.issue=6&rft.jtitle=Parasite+Immunol.&rft.pages=587-93&rft.volume=5&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_parasite-immunology_1983-11_5_6%2Fpage%2F587&rft_id=info%3Adoi%2F10.1111%2Fj.1365-3024.1983.tb00775.x&rft_id=info%3Apmid%2F6657297&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-duarte-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-duarte_6-0">^</a></b></span> <span class="reference-text"><cite class="citation journal">Duarte J, Deshpande P, Guiyedi V, Mécheri S, Fesel C, Cazenave PA, Mishra GC, Kombila M, Pied S (2007). <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC1781948">„Total and functional parasite specific IgE responses in Plasmodium falciparum-infected patients exhibiting different clinical status”</a>. <i>Malar. J</i>. <b>6</b>: 1. <a href="/wiki/PubMed_Central" title="PubMed Central">PMC</a> <span class="plainlinks"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC1781948">1781948</a> <span typeof="mw:File"><span title="Слободан приступ"><img alt="Слободан приступ" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png" decoding="async" width="9" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/14px-Lock-green.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/18px-Lock-green.svg.png 2x" data-file-width="512" data-file-height="813" /></span></span></span>. <a href="/wiki/PMID" title="PMID">PMID</a> <a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pubmed/17204149">17204149</a>. <a href="/wiki/Digitalni_identifikator_objekta" title="Digitalni identifikator objekta">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1186%2F1475-2875-6-1">10.1186/1475-2875-6-1</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AImunoglobulin+E&rft.atitle=Total+and+functional+parasite+specific+IgE+responses+in+Plasmodium+falciparum-infected+patients+exhibiting+different+clinical+status&rft.au=Cazenave%2C+PA&rft.au=Deshpande%2C+P&rft.au=Fesel%2C+C&rft.au=Guiyedi%2C+V&rft.au=Kombila%2C+M&rft.au=M%C3%A9cheri%2C+S&rft.au=Mishra%2C+GC&rft.au=Pied%2C+S&rft.aufirst=J&rft.aulast=Duarte&rft.date=2007&rft.genre=article&rft.jtitle=Malar.+J.&rft.pages=1&rft.volume=6&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1781948&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1781948&rft_id=info%3Adoi%2F10.1186%2F1475-2875-6-1&rft_id=info%3Apmid%2F17204149&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><cite class="citation journal">Alexander, Roy L.; Roodman, Stanford T.; Petruska, Paul J.; Tsai, Cheng C.; Janney, Christine G. <a rel="nofollow" class="external text" href="http://clinchem.aaccjnls.org/content/clinchem/38/11/2328.full.pdf">„A New Case of IgE Myeloma”</a> <span style="font-size:85%;">(PDF)</span>. <i>Clinical chemistry</i>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AImunoglobulin+E&rft.atitle=A+New+Case+of+IgE+Myeloma&rft.au=Janney%2C+Christine+G.&rft.au=Petruska%2C+Paul+J.&rft.au=Roodman%2C+Stanford+T.&rft.au=Tsai%2C+Cheng+C.&rft.aufirst=Roy+L.&rft.aulast=Alexander&rft.genre=article&rft.jtitle=Clinical+chemistry&rft_id=http%3A%2F%2Fclinchem.aaccjnls.org%2Fcontent%2Fclinchem%2F38%2F11%2F2328.full.pdf&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text"><cite class="citation journal">Hsu, Amy P.; Davis, Joie; Puck, Jennifer M.; Holland, Steven M.; Freeman, Alexandra F. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/books/NBK25507/">„Autosomal Dominant Hyper IgE Syndrome”</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AImunoglobulin+E&rft.atitle=Autosomal+Dominant+Hyper+IgE+Syndrome&rft.au=Davis%2C+Joie&rft.au=Freeman%2C+Alexandra+F.&rft.au=Holland%2C+Steven+M.&rft.au=Puck%2C+Jennifer+M.&rft.aufirst=Amy+P.&rft.aulast=Hsu&rft.genre=article&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fbooks%2FNBK25507%2F&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><cite class="citation journal">Burton, Oliver T.; Oettgen, Hans C. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122143/">„Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases”</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AImunoglobulin+E&rft.atitle=Beyond+immediate+hypersensitivity%3A+evolving+roles+for+IgE+antibodies+in+immune+homeostasis+and+allergic+diseases&rft.au=Oettgen%2C+Hans+C.&rft.aufirst=Oliver+T.&rft.aulast=Burton&rft.genre=article&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3122143%2F&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal" class="Z3988"><span style="display:none;"> </span></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text"><cite class="citation book">Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. <i>Osnovna imunologija</i> (5. изд.). Beograd.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AImunoglobulin+E&rft.au=Lichtman%2C+Andrew+H.&rft.au=Pillai%2C+Shiv&rft.aufirst=Abul+K.&rft.aulast=Abbas&rft.btitle=Osnovna+imunologija&rft.edition=5.&rft.genre=book&rft.place=Beograd&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook" class="Z3988"><span style="display:none;"> </span></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Literatura">Literatura</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Imunoglobulin_E&veaction=edit&section=8" title="Уредите одељак „Literatura”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Imunoglobulin_E&action=edit&section=8" title="Уреди извор одељка: Literatura"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r28440192">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li><cite id="CITEREFAbbasLichtmanPillai" class="citation book">Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. <i>Osnovna imunologija</i> (5. изд.). 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New York: W H Freeman and company. <a href="/wiki/Me%C4%91unarodni_standardni_broj_knjige" title="Međunarodni standardni broj knjige">ISBN</a> <a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A8%D1%82%D0%B0%D0%BC%D0%BF%D0%B0%D0%BD%D0%B8_%D0%B8%D0%B7%D0%B2%D0%BE%D1%80%D0%B8/1429202114" title="Посебно:Штампани извори/1429202114">1429202114</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AImunoglobulin+E&rft.au=Barbara+Anne+Osborne&rft.au=Janis+Kuby&rft.au=Richard+A.+Goldsby&rft.au=Thomas+J.+Kindt&rft.btitle=Kuby+Immunology&rft.date=2006&rft.edition=6&rft.genre=book&rft.isbn=1429202114&rft.place=New+York&rft.pub=W+H+Freeman+and+company&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fnlmcatalog%2F101275636&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook" class="Z3988"><span style="display:none;"> </span></span></li> <li>Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Osnovna imunologija (5. изд.). Beograd: DATA STATUS.</li> <li>Acharya, M; Borland, G; Edkins, A L.; MacLellan, L M.; Matheson, J; Ozanne, B W.; Cushley, W. (2010). „CD23/FcεRII: molecular multi-tasking”.</li> <li>Amarasekera, M. (2011). „Immunoglobulin E in health and disease”.</li> <li>Hakimi, John; Seals, Cary; Kondas, Ann; Pettine, Laura; Danho, Waleed; Kochan, Jarema. (1990). „The alpha Subunit of the Human IgE Receptor (FcERI) Is Sufficient for High Affinity IgE Binding”.</li> <li>Hamilton, Robert G. (2005). „Science behind the discovery of IgE”</li> <li>Kelly, Brian T.; Grayson, Mitchell H. (2016). „IgE, what is it good for?”.</li> <li>Platts-Mills, Thomas A.E. (2001). „The Role of Immunoglobulin E in Allergy and Asthma”.</li> <li><cite class="citation book">Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). <a rel="nofollow" class="external text" href="http://www.sciencedirect.com/science/book/9780124983403"><i>Cytokines (Handbook of Immunopharmacology)</i></a>. Boston: Academic Press. <a href="/wiki/Me%C4%91unarodni_standardni_broj_knjige" title="Međunarodni standardni broj knjige">ISBN</a> <a href="/wiki/%D0%9F%D0%BE%D1%81%D0%B5%D0%B1%D0%BD%D0%BE:%D0%A8%D1%82%D0%B0%D0%BC%D0%BF%D0%B0%D0%BD%D0%B8_%D0%B8%D0%B7%D0%B2%D0%BE%D1%80%D0%B8/0-12-498340-5" title="Посебно:Штампани извори/0-12-498340-5">0-12-498340-5</a>.</cite><span title="ctx_ver=Z39.88-2004&rfr_id=info%3Asid%2Fsr.wikipedia.org%3AImunoglobulin+E&rft.btitle=Cytokines+%28Handbook+of+Immunopharmacology%29&rft.date=1998&rft.genre=book&rft.isbn=0-12-498340-5&rft.place=Boston&rft.pub=Academic+Press&rft_id=http%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Fbook%2F9780124983403&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook" class="Z3988"><span style="display:none;"> </span></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="Spoljašnje_veze"><span id="Spolja.C5.A1nje_veze"></span>Spoljašnje veze</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Imunoglobulin_E&veaction=edit&section=9" title="Уредите одељак „Spoljašnje veze”" class="mw-editsection-visualeditor"><span>уреди</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Imunoglobulin_E&action=edit&section=9" title="Уреди извор одељка: Spoljašnje veze"><span>уреди извор</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/books/NBK27144/#325">Struktura antitela</a></li> <li><a rel="nofollow" class="external text" href="https://www.sciencedirect.com/topics/immunology-and-microbiology/immunoglobulin-e">Imunoglobulin E</a></li> <li><a rel="nofollow" class="external text" href="https://www.slideshare.net/allergy/allergy">Slide presentation of Degranulation processes</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r25469611">.mw-parser-output .hlist dl,.mw-parser-output .hlist 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href="/wiki/%D0%98%D0%BC%D1%83%D0%BD%D1%81%D0%BA%D0%B8_%D1%81%D0%B8%D1%81%D1%82%D0%B5%D0%BC" title="Имунски систем">Imunski sistem</a> / <a href="/wiki/%D0%98%D0%BC%D1%83%D0%BD%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%98%D0%B0" title="Имунологија">Imunologija</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: LightGreen">Sistemi</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Adaptivni_imunski_sistem" title="Adaptivni imunski sistem">Adaptivni</a> vs. <a href="/w/index.php?title=Uro%C4%91eni_imunski_sistem&action=edit&redlink=1" class="new" title="Urođeni imunski sistem (страница не постоји)">Urođeni</a> •  <a href="/wiki/%D0%A5%D1%83%D0%BC%D0%BE%D1%80%D0%B0%D0%BB%D0%BD%D0%B0_%D0%B8%D0%BC%D1%83%D0%BD%D0%BE%D1%81%D1%82" title="Хуморална имуност">Humoralna</a> vs. <a href="/w/index.php?title=%C4%86elijski-posredovanja_imunost&action=edit&redlink=1" class="new" title="Ćelijski-posredovanja imunost (страница не постоји)">Ćelijska</a> •  <a href="/w/index.php?title=Komplementni_sistem&action=edit&redlink=1" class="new" title="Komplementni sistem (страница не постоји)">Komplementni</a> (<a href="/wiki/Anafilatoksin" title="Anafilatoksin">Anafilatoksini</a>) •  <a href="/w/index.php?title=Unutra%C5%A1nja_imunost&action=edit&redlink=1" class="new" title="Unutrašnja imunost (страница не постоји)">Unutrašnja</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: LightGreen">Limfoidni</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Antigeni" scope="row" class="navbox-group" style="width:1%;background-color: LightGreen">Antigeni</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/%D0%90%D0%BD%D1%82%D0%B8%D0%B3%D0%B5%D0%BD" title="Антиген">Antigen</a> (<a href="/w/index.php?title=Superantigen&action=edit&redlink=1" class="new" title="Superantigen (страница не постоји)">Superantigen</a>, <a href="/wiki/%D0%90%D0%BB%D0%B5%D1%80%D0%B3%D0%B5%D0%BD" title="Алерген">Alergen</a>) •  <a href="/wiki/%D0%A5%D0%B0%D0%BF%D1%82%D0%B5%D0%BD" class="mw-redirect" title="Хаптен">Hapten</a><br /> <a href="/wiki/%D0%95%D0%BF%D0%B8%D1%82%D0%BE%D0%BF" title="Епитоп">Epitop</a> (<a href="/w/index.php?title=Linearni_epitop&action=edit&redlink=1" class="new" title="Linearni epitop (страница не постоји)">Linearni</a>, <a href="/w/index.php?title=Konformacioni_epitop&action=edit&redlink=1" class="new" title="Konformacioni epitop (страница не постоји)">Konformacioni</a>) •  <a href="/wiki/%D0%9C%D0%B8%D0%BC%D0%BE%D1%82%D0%BE%D0%BF" title="Мимотоп">Mimotop</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: LightGreen">Antitela</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/%D0%90%D0%BD%D1%82%D0%B8%D1%82%D0%B5%D0%BB%D0%BE" title="Антитело">Antitelo</a> (<a href="/wiki/Monoklonalna_antitela" class="mw-redirect" title="Monoklonalna antitela">Monoklonalna antitela</a>, <a href="/w/index.php?title=Poliklonalna_antitela&action=edit&redlink=1" class="new" title="Poliklonalna antitela (страница не постоји)">Poliklonalna antitela</a>, <a href="/w/index.php?title=Autoantitelo&action=edit&redlink=1" class="new" title="Autoantitelo (страница не постоји)">Autoantitelo</a>) •  <a href="/w/index.php?title=Odgovor_poliklonalnih_B_%C4%87elija&action=edit&redlink=1" class="new" title="Odgovor poliklonalnih B ćelija (страница не постоји)">Odgovor poliklonalnih B ćelija</a> •  <a href="/w/index.php?title=Imunoglobulinski_alotip&action=edit&redlink=1" class="new" title="Imunoglobulinski alotip (страница не постоји)">Alotip</a> •  <a href="/w/index.php?title=Izotip_(imunologija)&action=edit&redlink=1" class="new" title="Izotip (imunologija) (страница не постоји)">Izotip</a> •  <a href="/w/index.php?title=Idiotip&action=edit&redlink=1" class="new" title="Idiotip (страница не постоји)">Idiotip</a><br /> <a href="/w/index.php?title=Imunski_kompleks&action=edit&redlink=1" class="new" title="Imunski kompleks (страница не постоји)">Imunski kompleks</a> • <a href="/w/index.php?title=Paratop&action=edit&redlink=1" class="new" title="Paratop (страница не постоји)">Paratop</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: LightGreen">Imunost vs.<br /> tolerancija</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><i>akcija:</i> <a href="/w/index.php?title=Imunitet_(medicina)&action=edit&redlink=1" class="new" title="Imunitet (medicina) (страница не постоји)">Imunitet</a> •  <a href="/w/index.php?title=Autoimunitet&action=edit&redlink=1" class="new" title="Autoimunitet (страница не постоји)">Autoimunitet</a> •  <a href="/w/index.php?title=Aloimunitet&action=edit&redlink=1" class="new" title="Aloimunitet (страница не постоји)">Aloimunitet</a> •  <a href="/wiki/%D0%90%D0%BB%D0%B5%D1%80%D0%B3%D0%B8%D1%98%D0%B0" title="Алергија">Alergija</a> •  <a href="/wiki/Hipersenzitivnost" class="mw-redirect" title="Hipersenzitivnost">Hipersenzitivnost</a> •  <a href="/wiki/%D0%97%D0%B0%D0%BF%D0%B0%D1%99%D0%B5%D1%9A%D0%B5" title="Запаљење">Inflamacija</a> •  <a href="/w/index.php?title=Kros-reaktivnost&action=edit&redlink=1" class="new" title="Kros-reaktivnost (страница не постоји)">Kros-reaktivnost</a><br /><i>neaktivnost:</i> <a href="/w/index.php?title=Imunska_tolerancija&action=edit&redlink=1" class="new" title="Imunska tolerancija (страница не постоји)">Tolerancija</a> (<a href="/w/index.php?title=Centralna_tolerancija&action=edit&redlink=1" class="new" title="Centralna tolerancija (страница не постоји)">Centralna</a>, <a href="/w/index.php?title=Periferna_tolerancija&action=edit&redlink=1" class="new" title="Periferna tolerancija (страница не постоји)">Periferna</a>, <a href="/w/index.php?title=Klonalna_anergija&action=edit&redlink=1" class="new" title="Klonalna anergija (страница не постоји)">Klonalna anergija</a>, <a href="/w/index.php?title=Klonalno_brisanje&action=edit&redlink=1" class="new" title="Klonalno brisanje (страница не постоји)">Klonalno brisanje</a>, <a href="/w/index.php?title=Imunka_tolerancija_u_trudno%C4%87i&action=edit&redlink=1" class="new" title="Imunka tolerancija u trudnoći (страница не постоји)">Tolerancija u trudnoći</a>) •  <a href="/wiki/Imunodeficijencija" title="Imunodeficijencija">Imunodeficijencija</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: LightGreen"><a href="/w/index.php?title=Imunogenetika&action=edit&redlink=1" class="new" title="Imunogenetika (страница не постоји)">Imunogenetika</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/w/index.php?title=Somatska_hipermutacija&action=edit&redlink=1" class="new" title="Somatska hipermutacija (страница не постоји)">Somatska hipermutacija</a> •  <a href="/wiki/V(D)J_rekombinacija" title="V(D)J rekombinacija">V(D)J rekombinacija</a> •  <a href="/w/index.php?title=Sastavna_raznovrsnost&action=edit&redlink=1" class="new" title="Sastavna raznovrsnost (страница не постоји)">Sastavna raznovrsnost</a>  •  <a href="/w/index.php?title=Promena_imunoglobulinske_klase&action=edit&redlink=1" class="new" title="Promena imunoglobulinske klase (страница не постоји)">Promena imunoglobulinske klase</a> •  <a href="/w/index.php?title=Glavni_histokompatibilni_kompleks&action=edit&redlink=1" class="new" title="Glavni histokompatibilni kompleks (страница не постоји)">MHC</a>/<a href="/w/index.php?title=Ljudski_leukocitni_antigen&action=edit&redlink=1" class="new" title="Ljudski leukocitni antigen (страница не постоји)">HLA</a></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: LightGreen">Imunske ćelije/<br /><a href="/wiki/%D0%91%D0%B5%D0%BB%D0%B0_%D0%BA%D1%80%D0%B2%D0%BD%D0%B0_%D0%B7%D1%80%D0%BD%D1%86%D0%B0" title="Бела крвна зрнца">Bela krvna zrnca</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><b>Limfoid</b>: <a href="/wiki/T_%C4%87elija" class="mw-redirect" title="T ćelija">T ćelija</a> •  <a href="/wiki/%D0%91_%D1%9B%D0%B5%D0%BB%D0%B8%D1%98%D0%B0" class="mw-redirect" title="Б ћелија">B ćelija</a> •  <a href="/wiki/%D0%8B%D0%B5%D0%BB%D0%B8%D1%98%D0%B5_%D1%83%D0%B1%D0%B8%D1%86%D0%B5" title="Ћелије убице">NK ćelija</a> <p><b>Mijeloid</b>: <a href="/wiki/%D0%9C%D0%B0%D1%81%D1%82_%D1%9B%D0%B5%D0%BB%D0%B8%D1%98%D0%B0" class="mw-redirect" title="Маст ћелија">Mast ćelija</a> •  <a href="/w/index.php?title=Bazofil_granulocit&action=edit&redlink=1" class="new" title="Bazofil granulocit (страница не постоји)">Bazofil</a> •  <a href="/wiki/%D0%95%D0%BE%D0%B7%D0%B8%D0%BD%D0%BE%D1%84%D0%B8%D0%BB" title="Еозинофил">Eozinofil</a> •  <b><a href="/wiki/Fagocit" title="Fagocit">Fagociti</a></b> (<a href="/wiki/Neutrofil" title="Neutrofil">Neutrofil</a>, <a href="/wiki/%D0%9C%D0%B0%D0%BA%D1%80%D0%BE%D1%84%D0%B0%D0%B3" title="Макрофаг">Makrofag</a>/<a href="/w/index.php?title=Retikuloendotelni_sistem&action=edit&redlink=1" class="new" title="Retikuloendotelni sistem (страница не постоји)">Retikuloendotelni sistem</a>) </p> <b><a href="/w/index.php?title=Antigen-prezentiraju%C4%87e_%C4%87elije&action=edit&redlink=1" class="new" title="Antigen-prezentirajuće ćelije (страница не постоји)">APC</a></b>: <a href="/wiki/%D0%94%D0%B5%D0%BD%D0%B4%D1%80%D0%B8%D1%82%D1%81%D0%BA%D0%B0_%D1%9B%D0%B5%D0%BB%D0%B8%D1%98%D0%B0" title="Дендритска ћелија">Dendritskа ćelija</a> •  <a href="/wiki/%D0%9C%D0%B0%D0%BA%D1%80%D0%BE%D1%84%D0%B0%D0%B3" title="Макрофаг">Makrofag</a> •  <a href="/wiki/%D0%91_%D1%9B%D0%B5%D0%BB%D0%B8%D1%98%D0%B0" class="mw-redirect" title="Б ћелија">B ćelija</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: LightGreen">Supstance</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/%D0%A6%D0%B8%D1%82%D0%BE%D0%BA%D0%B8%D0%BD" title="Цитокин">Citokini</a> •  <a href="/wiki/Opsonin" title="Opsonin">Opsonin</a> •  <a href="/w/index.php?title=Citolizin&action=edit&redlink=1" class="new" title="Citolizin (страница не постоји)">Citolizin</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: LightGreen"><a href="/w/index.php?title=Limfopoeza&action=edit&redlink=1" class="new" title="Limfopoeza (страница не постоји)">Limfopoeza</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/w/index.php?title=Limfoblast&action=edit&redlink=1" class="new" title="Limfoblast (страница не постоји)">Limfoblast</a> •  <a href="/w/index.php?title=Prolimfocit&action=edit&redlink=1" class="new" title="Prolimfocit (страница не постоји)">Prolimfocit</a> •  <a href="/w/index.php?title=Timocit&action=edit&redlink=1" class="new" title="Timocit (страница не постоји)">Timocit</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: LightGreen">Drugi</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/w/index.php?title=Dijagnosti%C4%8Dka_imunologija&action=edit&redlink=1" class="new" title="Dijagnostička imunologija (страница не постоји)">Dijagnostička imunologija</a>  •  <a href="/wiki/%D0%9E%D1%82%D0%BF%D0%BE%D1%80%D0%BD%D0%BE%D1%81%D1%82_%D0%BD%D0%B0_%D0%B1%D0%B8%D1%99%D0%BD%D0%B5_%D0%B1%D0%BE%D0%BB%D0%B5%D1%81%D1%82%D0%B8" title="Отпорност на биљне болести">Otpornost na biljne bolesti</a>  •  <a href="/w/index.php?title=Antimikrobni_odbrambeni_sistem_respiratorni_trakta&action=edit&redlink=1" class="new" title="Antimikrobni odbrambeni sistem respiratorni trakta (страница не постоји)">Antimikrobni odbrambeni sistem respiratorni trakta</a></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background:LightGreen;"><div></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0;background:transparent;color:inherit;"><div style="padding:0px;"><table class="navbox-columns-table" style="border-spacing: 0px; text-align:left;width:100%;"><tbody><tr style="vertical-align:top;"><td class="navbox-list" style="padding:0px;text-align:center;background:#efefef;;;text-align:center;background:LightGreen;;width:10em;"><div> <p><a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Medicina_navs-lat" title="Шаблон:Medicina navs-lat">M</a>: <a href="/wiki/%D0%9B%D0%B8%D0%BC%D1%84%D0%BE%D1%86%D0%B8%D1%82%D0%B8" class="mw-redirect" title="Лимфоцити">LMC</a> </p> </div></td><td class="navbox-list" style="border-left:2px solid #fdfdfd;padding:0px;text-align:center;background:#efefef;;;text-align:center;background:white;;width:10em;"><div> <p><a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Limfociti-lat&action=edit&redlink=1" class="new" title="Шаблон:Limfociti-lat (страница не постоји)">ćelije</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Imunski_sistem-lat" title="Шаблон:Imunski sistem-lat">fis</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Autoantigeni-lat&action=edit&redlink=1" class="new" title="Шаблон:Autoantigeni-lat (страница не постоји)">auag</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Autoantitela-lat&action=edit&redlink=1" class="new" title="Шаблон:Autoantitela-lat (страница не постоји)">auab</a> </p> </div></td><td class="navbox-list" style="border-left:2px solid #fdfdfd;padding:0px;text-align:center;background:#efefef;;;text-align:center;background:silver;;width:10em;"><div> <p><a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Limfoid_i_komplement_imunodeficit-lat&action=edit&redlink=1" class="new" title="Шаблон:Limfoid i komplement imunodeficit-lat (страница не постоји)">imdf</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Imunoproliferativni_imunoglobulinski_poreme%C4%87aji-lat&action=edit&redlink=1" class="new" title="Шаблон:Imunoproliferativni imunoglobulinski poremećaji-lat (страница не постоји)">ipig</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Hipersenzitivnost_i_autoimune_bolesti-lat&action=edit&redlink=1" class="new" title="Шаблон:Hipersenzitivnost i autoimune bolesti-lat (страница не постоји)">hyps</a>/<a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Limfoidna_malignost-lat&action=edit&redlink=1" class="new" title="Шаблон:Limfoidna malignost-lat (страница не постоји)">tumr</a> </p> </div></td><td class="navbox-list" style="border-left:2px solid #fdfdfd;padding:0px;text-align:center;background:#efefef;;;text-align:center;background:#ccf;;width:10em;"><div> <p><a href="/w/index.php?title=%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Hemi%C4%8Dne/limfati%C4%8Dne_precedure-lat&action=edit&redlink=1" class="new" title="Шаблон:Hemične/limfatične precedure-lat (страница не постоји)">proc</a>, lek (<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Imunostimulanti-lat" title="Шаблон:Imunostimulanti-lat">L3</a>/<a href="/wiki/%D0%A8%D0%B0%D0%B1%D0%BB%D0%BE%D0%BD:Imunosupresanti-lat" title="Шаблон:Imunosupresanti-lat">4</a>) </p> </div></td></tr></tbody></table></div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r26481770">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output .portal-bar-related{font-size:100%;justify-content:flex-start}.mw-parser-output .portal-bar-unbordered{padding:0 1.7em;margin-left:0}.mw-parser-output .portal-bar-header{margin:0 1em 0 0.5em;flex:0 0 auto;min-height:24px}.mw-parser-output .portal-bar-content{display:flex;flex-flow:row wrap;flex:0 1 auto;padding:0.15em 0;column-gap:1em;align-items:baseline;margin:0;list-style:none}.mw-parser-output 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