Adaptive Design Clinical Trials

<!doctype html><html lang="en"><head> <meta charset="utf-8"> <title>Adaptive Design Clinical Trials </title> <link rel="shortcut icon" href="https://www.veristat.com/hubfs/favicon.ico"> <meta name="description" content="Adaptive design clinical trials offer many benefits to clinical trial efficiency such as reducing the overall time and cost of the trial and improving patient safety."> <meta name="viewport" content="width=device-width, initial-scale=1"> <script src="/hs/hsstatic/jquery-libs/static-1.1/jquery/jquery-1.7.1.js"></script> <script>hsjQuery = window['jQuery'];</script> <meta property="og:description" content="Adaptive design clinical trials offer many benefits to clinical trial efficiency such as reducing the overall time and cost of the trial and improving patient safety."> <meta property="og:title" content="Adaptive Design Clinical Trials "> <meta name="twitter:description" content="Adaptive design clinical trials offer many benefits to clinical trial efficiency such as reducing the overall time and cost of the trial and improving patient safety."> <meta name="twitter:title" content="Adaptive Design Clinical Trials "> <style> a.cta_button{-moz-box-sizing:content-box !important;-webkit-box-sizing:content-box !important;box-sizing:content-box !important;vertical-align:middle}.hs-breadcrumb-menu{list-style-type:none;margin:0px 0px 0px 0px;padding:0px 0px 0px 0px}.hs-breadcrumb-menu-item{float:left;padding:10px 0px 10px 10px}.hs-breadcrumb-menu-divider:before{content:'›';padding-left:10px}.hs-featured-image-link{border:0}.hs-featured-image{float:right;margin:0 0 20px 20px;max-width:50%}@media (max-width: 568px){.hs-featured-image{float:none;margin:0;width:100%;max-width:100%}}.hs-screen-reader-text{clip:rect(1px, 1px, 1px, 1px);height:1px;overflow:hidden;position:absolute !important;width:1px} </style> <link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63712159645/1726675697504/VERISTAT-CLEAN-2022/css/main-head.css"> <link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63712050360/1732158771693/VERISTAT-CLEAN-2022/css/main-foot.min.css"> <link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63711874203/1726675694524/VERISTAT-CLEAN-2022/css/modules/global-header-v2.min.css"> <style> /******************************* MAIN DESKTOP NAV STYLE *******************************/ .hhs-top-bar { background-color: rgba(249, 249, 249, 1); padding: 12px 0; } .hhs-top-bar.sticky-menu.active { padding: 12px 0; } /* LOGOS */ .hhs-top-bar.hhs-alt-nav .logo-sticky, .logo-standard { max-width: 220px; float: left; } .hhs-top-bar.hhs-alt-nav.sticky-menu.active .logo-sticky, .logo-sticky { max-width: 240px; float: left; } .hhs-header-logo { padding-top: 0px; } /* MENU STYLE */ .hhs-nav-grid__menu { margin: 0 auto; } .hhs-top-bar .hs-menu-wrapper.hs-menu-flow-horizontal>ul li a, .hs-menu-wrapper.hs-menu-flow-horizontal ul.hhs-nav-links .hs-menu-item a { color: rgba(74, 74, 74, 1.0); } .hhs-top-bar .hs-menu-wrapper.hs-menu-flow-horizontal>ul li { margin: 15px 10px; } .hhs-top-bar .hs-menu-wrapper.hs-menu-flow-horizontal>ul li a:hover, .hs-menu-wrapper.hs-menu-flow-horizontal ul.hhs-nav-links .hs-menu-item a:hover, .hhs-top-bar .hs-menu-wrapper.hs-menu-flow-horizontal>ul li a:hover, .hhs-header-search a i:hover, .hhs-lang-switch .globe_class:hover{ color: rgba(153, 153, 153, 1.0); } .hhs-header-search a i{ color: rgba(74, 74, 74, 1); 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} .hhs-top-bar.sticky-menu .hs-menu-wrapper.hs-menu-flow-horizontal>ul li a:hover, .hhs-top-bar.hhs-alt-nav .hs-menu-wrapper.hs-menu-flow-horizontal>ul li a:hover, .hhs-top-bar.hhs-alt-nav .hhs-top-bar .hs-menu-wrapper.hs-menu-flow-horizontal .hs-menu-depth-1:first-child:hover, .hhs-top-bar.hhs-alt-nav .hhs-header-search a i:hover, .hhs-top-bar.hhs-alt-nav .fas:hover, .hhs-top-bar.hhs-alt-nav .hhs-lang-switch .globe_class:before, .sticky-menu .hhs-top-bar .hs-menu-wrapper.hs-menu-flow-horizontal .hs-menu-depth-1:first-child:hover, .sticky-menu .hs-menu-wrapper.hs-menu-flow-horizontal ul.hhs-nav-links li a:hover, .sticky-menu .hhs-header-search a i:hover{ color: rgba(0, 0, 0, 1.0); } .hhs-top-bar.hhs-alt-nav .hhs-header-search a i, .hhs-top-bar.hhs-alt-nav .globe_class { color: rgba(68, 68, 68, 1) !important; } .hhs-top-bar.hhs-alt-nav .hhs-top-bar .hs-menu-wrapper.hs-menu-flow-horizontal>ul li a:hover, .hhs-top-bar.hhs-alt-nav .hhs-header-search a i:hover, .hhs-top-bar.hhs-alt-nav .globe_class:hover { color: rgba(0, 0, 0, 1) !important; } .hhs-top-bar.hhs-alt-nav .hs-menu-wrapper.hs-menu-flow-horizontal>ul li.hs-menu-depth-1.active:after, .hhs-top-bar.hhs-alt-nav .hs-menu-wrapper.hs-menu-flow-horizontal>ul li.hs-menu-depth-1:after, .sticky-menu.hhs-top-bar .hs-menu-wrapper.hs-menu-flow-horizontal>ul li.hs-menu-depth-1.active:after, .sticky-menu.hhs-top-bar .hs-menu-wrapper.hs-menu-flow-horizontal>ul li.hs-menu-depth-1:after { background-color: rgba(0, 164, 189, 1.0); } /* CTA */ .hhs-header-cta .cta-secondary, .hhs-header-cta .cta-tertiary, .hhs-header-cta .cta-primary { padding: 15px 15px !important; font-size: 10px !important; -webkit-box-shadow: none; box-shadow: none; } /******************************* END *******************************/ /******************************* SIDE MENU *******************************/ .hhs-side-menu { width: 320px; } .hhs-side-menu { background-color: rgba(255, 255, 255, 1.0); } .body-wrapper::after { background-color: rgba(0, 0, 0, 0.3); } /* ICON */ .hamburger-icon .line { background: rgba(0, 102, 51, 1.0); } .hhs-top-bar.hhs-alt-nav .hamburger-icon .line, .sticky-menu .hamburger-icon .line { background: rgba(68, 68, 68, 1.0); } .hamburger-icon.active .line { background: rgba(68, 68, 68, 1.0); } .hhs-side-menu__controls .hhs-lang-switch { right: 70px !important; } /* LANG GLOBE & SEARCH */ .hhs-side-menu .hhs-lang-switch .globe_class:before, .hhs-side-menu .fas{ color: rgba(68, 68, 68, 1.0); } .hhs-top-bar .fas { color: #4A4A4A; } .hhs-side-menu__footer a i, .hhs-side-menu__footer a:visited i { color: #333333; } .hhs-side-menu__footer a:hover i, .hhs-side-menu__footer a:focus i { color: #666666; } /** MAIN MENU **/ .hhs-side-menu .hhs-side-menu__mobile li a { font-size: 18px; font-weight: nomral; color: rgba(102, 102, 102, 1.0); } .hhs-side-menu .hhs-side-menu__mobile li a:hover { color: rgba(0, 0, 0, 1.0); } .hhs-sidebar-nav-toggle i { color: rgba(153, 153, 153, 1.0); } /** EXTRAS MENU **/ .hhs-side-menu__extras .hs-menu-item a, .hhs-side-menu__extras .hs-menu-wrapper.hs-menu-flow-horizontal>ul li.hs-item-has-children ul.hs-menu-children-wrapper a { font-size: 14px; font-weight: nomral; color: rgba(74, 74, 74, 1); } .hhs-side-menu__extras .hs-menu-item a:hover, .hhs-side-menu__extras .hs-menu-wrapper.hs-menu-flow-horizontal>ul li.hs-item-has-children ul.hs-menu-children-wrapper a:hover { color: rgba(0, 164, 189, 1); } /* FOR LAST BLOCK IN SIDE MENU */ .hhs-side-menu__extras {flex: 1;} @media (max-width: 575px) { .hhs-side-menu { width: 100%; } } /******************************* END *******************************/ /******************************* MEGA MENU *******************************/ /******************************* END *******************************/ /******************************* RESPONSIVE SIDE MENU *******************************/ .hhs-menu-toggle { display: none; } @media (max-width: 960px) { .hhs-menu-toggle { display: block; } } @media (max-width: 920px) { .hhs-menu-toggle { display: block; } } /* CTAS */ .hhs-side-menu__ctas .hhs-side-cta-1, .hhs-side-menu__ctas .hhs-side-cta-2{ display: none; } @media (max-width: 960px) { .hhs-extras-ctas, .hhs-extras-ctas .hhs-head-cta-1 { display: none; } .hhs-side-menu__ctas .hhs-side-cta-1 { display: inline-block; } } @media (max-width: 920px) { .hhs-extras-ctas .hhs-head-cta-2 { display: none; } .hhs-side-menu__ctas .hhs-side-cta-2 { display: inline-block; } } /* MAIN NAV */ @media (min-width: 768px) { .hhs-side-menu__mobile { display: none; } } @media (max-width: 768px) { .main-nav .sc-site-header__menu { display: none; } } /* FORM */ /******************************* END *******************************/ /******************************* HEADER HAT *******************************/ .hhs-header-hat { background-color: rgba(0, 102, 51, 1.0); padding: 5px 0; } .hhs-hat-menu .hs-menu-wrapper.hs-menu-flow-horizontal>ul li.hs-menu-depth-1 a { color: rgba(255, 255, 255, 1.0); font-size: 12px; font-weight: normal; } .hhs-hat-menu .hs-menu-wrapper.hs-menu-flow-horizontal>ul li.hs-menu-depth-1 a:hover { color: rgba(238, 238, 238, 1.0); } @media (max-width: 575px) { .hhs-header-hat { display: none; } } /******************************* END *******************************/ /** TABLET CSS **/ @media (max-width: 768px) { .custom-menu-primary .hs-menu-wrapper > ul { margin-top: 10px !important; } .custom-menu-primary .hs-menu-wrapper > ul, .custom-menu-primary .hs-menu-wrapper > ul li.active a:hover{ background-color: rgba(0, 102, 51, 1) !important; } .hhs-top-bar .hs-menu-wrapper.hs-menu-flow-horizontal>ul li a:hover, .custom-menu-primary .hs-menu-wrapper > ul li.active a:hover { color: #FFFFFF ; } .custom-menu-primary .hs-menu-wrapper > ul li{ border-top: 1px solid rgba(255, 255, 255, .2) !important; } .custom-menu-primary .hs-menu-wrapper > ul ul li{ background-color: rgba(255, 255, 255, .15); } .sticky-menu.active { position: static !important; } .sticky-menu.active { display: none !important; height: 0px !important; } } /** MOBILE CSS **/ @media (max-width: 575px) { .logo-standard, .logo-sticky { max-width: 140px !important; } .hhs-nav-opt-items .hhs-header-search { right: 3px; } .hhs-nav-opt-items .hhs-lang-switch { right: 33px; } } </style> <link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63706222910/1726675698575/VERISTAT-CLEAN-2022/css/modules/global-footer.min.css"> <style> /******************************* MAIN DESKTOP NAV STYLE *******************************/ #hs_cos_wrapper_global_footer .hhs-footer-mod { padding-top: 50px; padding-bottom: 25px; background-color: rgba(244, 244, 244, 1.0); } /** NAVIGATION COLUMNS STYLE **/ .hhs-foot-base-nav .hs-menu-wrapper.hs-menu-flow-horizontal > ul li a, .hhs-foot-nav-col .hs-menu-wrapper.hs-menu-flow-horizontal>ul li.hs-item-has-children ul.hs-menu-children-wrapper li a, .hhs-foot-nav-col .hs-menu-wrapper.hs-menu-flow-horizontal > ul li a { color: #888888 !important; } .hhs-foot-base-nav .hs-menu-wrapper.hs-menu-flow-horizontal > ul li a:hover, .hhs-foot-nav-col .hs-menu-wrapper.hs-menu-flow-horizontal>ul li.hs-item-has-children ul.hs-menu-children-wrapper li a:hover, .hhs-foot-nav-col .hs-menu-wrapper.hs-menu-flow-horizontal > ul li a:hover { color: #555555 !important; } .foot-nav-title, .hhs-foot-rss h5, .hhs-foot-nav-col h5 { margin-bottom: 28px; color: #006633; } .hhs-foot-rss .hs_cos_wrapper_type_inline_rich_text p, .hhs-foot-rss .hs_cos_wrapper_type_inline_rich_text l1, .hhs-foot-rss .hs_cos_wrapper_type_inline_rich_text span, .hhs-foot-rss label{ color: #4A4A4A; } .hhs-foot-base-nav .hs-menu-wrapper.hs-menu-flow-horizontal > ul li a { font-size: 13px; } /** BLOG POST STYLE **/ .hhs-footer-mod .hhs-post-content a h6 { color: #FFFFFF; font-size: 16px; line-height: 20px; } .hhs-footer-mod .hhs-post-summary p { color: #4A4A4A; font-size: 14px; line-height: 18px; } .hhs-foot-rss .hs-rss-title:hover { color: #00a4bd; } .hhs-footer-mod .hhs-post-feat-img { min-height: 120px; } .hhs-foot-rss .hs-rss-item.hs-with-featured-image .hs-rss-item-text { margin-top: 120px; } .hhs-foot-break-line { border-color: #006633; } .hhs-foot-copyright { color: #006633; } /** TOGGLE COLLAPSE **/ @media (max-width: 575px) { .hhs-foot-nav-col .hhs-col-content { display: none; text-align: center; } .hhs-foot-nav-col .hhs-col-content.open-menu { display: block; text-align: center; } } /** SOCIAL ICONS **/#hs_cos_wrapper_global_footer .hhs-social-con i { color: #006633;} #hs_cos_wrapper_global_footer .hhs-social-con i:hover {color: #9CCD4E;}/** TABLET CSS **/ @media (max-width: 768px) { #hs_cos_wrapper_global_footer .hhs-footer-mod { padding-top: 25px; padding-bottom: 25px; } } /** BACK TO TOP **/ #return-to-top { background: rgba(68, 68, 68, 0.7); } #return-to-top:hover { background: rgba(68, 68, 68, 0.9); } /** MOBILE CSS **/ @media (max-width: 575px) { #hs_cos_wrapper_global_footer .hhs-footer-mod { padding-top: 25px; padding-bottom: 25px; } .hhs-foot-nav-col { border-color: #006633; } } </style> <style> </style> <link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/module_assets/63712049542/1732009637377/module_63712049542_VERIS_-_Row_-_Multi-Column_Content.min.css"> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_widget_1648499013781 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px;background-color: rgba(#null, 0.0);} @media (max-width: 768px) { #hs_cos_wrapper_widget_1648499013781 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1648499013781 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text li, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1648499013781 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <link class="hs-async-css" rel="preload" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63711874859/1726675697348/VERISTAT-CLEAN-2022/css/modules/row-multi-column-content.min.css" as="style" onload="this.onload=null;this.rel='stylesheet'"> <noscript><link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63711874859/1726675697348/VERISTAT-CLEAN-2022/css/modules/row-multi-column-content.min.css"></noscript> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_module_1647484281510 .hhs-text-mod { padding-top: 50px; padding-bottom: 0px;background-color: rgba(255, 255, 255, 0.20);} @media (max-width: 768px) { #hs_cos_wrapper_module_1647484281510 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_module_1647484281510 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text li, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_1647484281510 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_widget_1642359942501 .hhs-text-mod { padding-top: 10px; padding-bottom: 50px;background-color: rgba(255, 255, 255, 1);} @media (max-width: 768px) { #hs_cos_wrapper_widget_1642359942501 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1642359942501 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text li, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1642359942501 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_widget_1647484156143 .hhs-testimonial-card-mod { padding-top: 50px; padding-bottom: 50px; background-color: rgba(#null, 0.0); } @media (max-width: 768px) { #hs_cos_wrapper_widget_1647484156143 .hhs-testimonial-card-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1647484156143 .hhs-testimonial-card-mod { padding-top: 25px; padding-bottom: 25px; } } /* SHADOW */ /* PARALLAX */ /* OVERLAY */ /* PULL UP */ /* WAVE *//******************************* END *******************************/ /******************************* CARD STYLE *******************************/ #hs_cos_wrapper_widget_1647484156143 .hhs-testimonial-card { background: rgba(0, 86, 125, 0.30); padding: 16px; } #hs_cos_wrapper_widget_1647484156143 .hhs-testimonial-content { padding: 0px; text-align: center; } #hs_cos_wrapper_widget_1647484156143 .hhs-testimonial-card blockquote {font-size: 20px;} #hs_cos_wrapper_widget_1647484156143 .hhs-testimonial-card img { text-align: center; display: block; margin: 0 auto 16px; } /* STAR RATING */ #hs_cos_wrapper_widget_1647484156143 .star-rating .star-solid { color: #f1a604; } #hs_cos_wrapper_widget_1647484156143 .star-rating .star-outline { color: #ccc; } </style> <link class="hs-async-css" rel="preload" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63705167760/1726675699372/VERISTAT-CLEAN-2022/css/modules/row-testimonial-cards.min.css" as="style" onload="this.onload=null;this.rel='stylesheet'"> <noscript><link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63705167760/1726675699372/VERISTAT-CLEAN-2022/css/modules/row-testimonial-cards.min.css"></noscript> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_widget_1699384159426 .hhs-img-text-mod { background-color: rgba(255, 255, 255, 1.0); } /* SHADOW */ /******************************* END *******************************/ /******************************* TEXT COLUMN *******************************/ #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text { padding-top: 100px; padding-bottom: 100px; padding-right: 100px; padding-left: 100px; } #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text h1, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text h2,#hs_cos_wrapper_widget_1699384159426 .hhs-rich-text h3, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text h4, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text h5, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text h6, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text p, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text span, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text li { text-align: left; } #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h1, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img.overlay-img h2,#hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h3, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h4, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h5, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h6 { z-index: 10; position: relative; margin-left: -160px; } #hs_cos_wrapper_widget_1699384159426 .hhs-divider.overlay-img { margin-left: -160px !important; text-align: left; } /* DIVIDER */ #hs_cos_wrapper_widget_1699384159426 .hhs-divider {margin-right: 50px; margin-left: 0px;} #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img { position: relative; z-index: 10; } /******************************* END *******************************/ /******************************* TABLET *******************************/ @media (max-width: 768px) { #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text { padding-top: 50px; padding-bottom: 50px; padding-right: 50px; padding-left: 50px; } #hs_cos_wrapper_widget_1699384159426 .hhs-bg-image {background-image: none; } #hs_cos_wrapper_widget_1699384159426 .hhs-reg-image {display: block;} #hs_cos_wrapper_widget_1699384159426 .hhs-divider.overlay-img { margin-left: unset !important; text-align: left; } #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h1, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img.overlay-img h2,#hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h3, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h4, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h5, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h6 { z-index: 1; position: relative; margin-left: unset; background-color: none; padding: 0 !important; } } /******************************* END *******************************/ /******************************* MOBILE *******************************/ @media (max-width: 575px) { #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text { padding-top: 50px; padding-bottom: 50px; padding-right: 50px; padding-left: 50px; } #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text h1, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text h2,#hs_cos_wrapper_widget_1699384159426 .hhs-rich-text h3, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text h4, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text h5, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text h6, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text p, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text span, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text li { text-align: left; } #hs_cos_wrapper_widget_1699384159426 .hhs-bg-image { background-image: none; } #hs_cos_wrapper_widget_1699384159426 .hhs-reg-image {display: block;} #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h1, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img.overlay-img h2,#hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h3, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h4, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h5, #hs_cos_wrapper_widget_1699384159426 .hhs-rich-text.overlay-img h6 { z-index: 1; position: relative; margin-left: unset; background-color: none; padding: 0 !important; } #hs_cos_wrapper_widget_1699384159426 .hhs-divider.overlay-img { margin-left: unset; text-align: left; } #hs_cos_wrapper_widget_1699384159426 .hhs-divider.overlay-img { margin-left: unset !important; } #hs_cos_wrapper_widget_1699384159426 .hhs-divider {margin-right: 50px; margin-left: 0px;} } </style> <link class="hs-async-css" rel="preload" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63711647333/1726675693076/VERISTAT-CLEAN-2022/css/modules/row-image-text-opt1.min.css" as="style" onload="this.onload=null;this.rel='stylesheet'"> <noscript><link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63711647333/1726675693076/VERISTAT-CLEAN-2022/css/modules/row-image-text-opt1.min.css"></noscript> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_widget_1642360381667 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px;background-color: rgba(155, 155, 155, 0.20);} @media (max-width: 768px) { #hs_cos_wrapper_widget_1642360381667 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1642360381667 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text li, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1642360381667 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_widget_1699377647169 .hhs-img-hover { padding-top: 50px; padding-bottom: 50px; background-color: rgba(255, 255, 255, 1); } @media (max-width: 768px) { #hs_cos_wrapper_widget_1699377647169 .hhs-img-hover { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1699377647169 .hhs-img-hover { padding-top: 25px; padding-bottom: 25px; } } /* SHADOW */ /* PARALLAX */ /* OVERLAY *//* WAVE *//******************************* END *******************************/ /******************************* ALL COLUMN STYLES *******************************/ #hs_cos_wrapper_widget_1699377647169 .hhs-img-hover-con { height: 300px; -webkit-border-radius: 5px; border-radius: 5px; } #hs_cos_wrapper_widget_1699377647169 .hhs-img-hover-front, #hs_cos_wrapper_widget_1699377647169 .hhs-img-hover-back{ padding: 30px 30px 0 0; } #hs_cos_wrapper_widget_1699377647169 .img-hover-overlay { -webkit-border-radius: 5px; border-radius: 5px; } #hs_cos_wrapper_widget_1699377647169 .hhs-img-hover-con .hhs-img-hover-back , #hs_cos_wrapper_widget_1699377647169 .hhs-img-hover-con .hhs-img-hover-front { bottom: 30px; left: 30px; } @media (max-width: 768px) { } @media (max-width: 575px) { #hs_cos_wrapper_widget_1699377647169 .hhs-img-hover-con { height: 500px; } } /******************************* END *******************************/ /******************************* COLOUMN 1 *******************************/ #hs_cos_wrapper_widget_1699377647169 .c1 .img-hover-overlay { background-color: rgba(0, 0, 0, 0.40); } #hs_cos_wrapper_widget_1699377647169 .c1 .hhs-img-hover-con:hover .img-hover-overlay { background-color: rgba(51, 71, 91, 0.80); } /******************************* END *******************************/ /******************************* COLOUMN 2 *******************************/ #hs_cos_wrapper_widget_1699377647169 .c2 .img-hover-overlay { background-color: rgba(0, 0, 0, 0.40); } #hs_cos_wrapper_widget_1699377647169 .c2 .hhs-img-hover-con:hover .img-hover-overlay { background-color: rgba(51, 71, 91, 0.80); } /******************************* END *******************************/ /******************************* COLOUMN 3 *******************************/ #hs_cos_wrapper_widget_1699377647169 .c3 .img-hover-overlay { background-color: rgba(0, 0, 0, 0.40); } #hs_cos_wrapper_widget_1699377647169 .c3 .hhs-img-hover-con:hover .img-hover-overlay { background-color: rgba(51, 71, 91, 0.80); } /******************************* END *******************************/ /******************************* COLOUMN 4 *******************************/ #hs_cos_wrapper_widget_1699377647169 .c4 .img-hover-overlay { background-color: rgba(0, 0, 0, 0.40); } #hs_cos_wrapper_widget_1699377647169 .c4 .hhs-img-hover-con:hover .img-hover-overlay { background-color: rgba(51, 71, 91, 0.80); } </style> <link class="hs-async-css" rel="preload" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63711874207/1726675693999/VERISTAT-CLEAN-2022/css/modules/row-hover-cards.min.css" as="style" onload="this.onload=null;this.rel='stylesheet'"> <noscript><link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63711874207/1726675693999/VERISTAT-CLEAN-2022/css/modules/row-hover-cards.min.css"></noscript> <link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/module_assets/64083269483/1651863340236/module_64083269483_LS_-_Horizontal_Timeline.min.css"> <style> #widget_1647483668900 .horizontal-input.active, #widget_1647483668900 .horizontal-input:hover, #widget_1647483668900 .horizontal-flex-parent .horizontal-input.active::before, #widget_1647483668900 .horizontal-flex-parent:not(.mobile-look) .horizontal-input, #widget_1647483668900 .horizontal-flex-parent .horizontal-input::before, #widget_1647483668900 .horizontal-flex-parent .horizontal-input::after, #widget_1647483668900 .horizontal-flex-parent .horizontal-input { background-color: #006633; } @media (max-width: 600px) { #widget_1647483668900 .horizontal-input { background-color: rgba(0, 102, 51,0.6); } } #widget_1647483668900 .horizontal-input span svg { fill: #FFFFFF; } #widget_1647483668900 .horizontal-input.active span svg { fill: #FFFFFF; } #widget_1647483668900 .horizontal-input.active ~ .horizontal-input, #widget_1647483668900 .horizontal-input.active ~ .horizontal-input::before, #widget_1647483668900 .horizontal-input.active ~ .horizontal-input::after, #widget_1647483668900 .horizontal-flex-parent .horizontal-input.active::after{ background-color: #b3b3b3; } #widget_1647483668900 .horizontal-description-flex-container { background-color: rgba(255, 255, 255, 1.0); border: 3px solid #EEEEEE; border-radius: 3px; max-width: 1100px; } #widget_1647483668900 .horizontal-flex-parent.mobile-look .horizontal-input span::after { color: ; } </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_module_1647460878802 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px;background-color: #EEEEEE; background: -moz-linear-gradient(top, #EEEEEE 0%, #FFFFFF 100%); background: -webkit-linear-gradient(top, #EEEEEE 0%, #FFFFFF 100%); background: linear-gradient(top, #EEEEEE 0%, #FFFFFF 100%); } @media (max-width: 768px) { #hs_cos_wrapper_module_1647460878802 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_module_1647460878802 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text li, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h1, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h2,#hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h3, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h4, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h5, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text h6, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text p, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text span, #hs_cos_wrapper_module_1647460878802 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_widget_1700166755361 .hhs-img-hover { padding-top: 50px; padding-bottom: 50px; background-color: rgba(255, 255, 255, 1); } @media (max-width: 768px) { #hs_cos_wrapper_widget_1700166755361 .hhs-img-hover { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1700166755361 .hhs-img-hover { padding-top: 25px; padding-bottom: 25px; } } /* SHADOW */ /* PARALLAX */ /* OVERLAY *//* WAVE *//******************************* END *******************************/ /******************************* ALL COLUMN STYLES *******************************/ #hs_cos_wrapper_widget_1700166755361 .hhs-img-hover-con { height: 300px; -webkit-border-radius: 5px; border-radius: 5px; } #hs_cos_wrapper_widget_1700166755361 .hhs-img-hover-front, #hs_cos_wrapper_widget_1700166755361 .hhs-img-hover-back{ padding: 30px 30px 0 0; } #hs_cos_wrapper_widget_1700166755361 .img-hover-overlay { -webkit-border-radius: 5px; border-radius: 5px; } #hs_cos_wrapper_widget_1700166755361 .hhs-img-hover-con .hhs-img-hover-back , #hs_cos_wrapper_widget_1700166755361 .hhs-img-hover-con .hhs-img-hover-front { bottom: 30px; left: 30px; } @media (max-width: 768px) { } @media (max-width: 575px) { #hs_cos_wrapper_widget_1700166755361 .hhs-img-hover-con { height: 500px; } } /******************************* END *******************************/ /******************************* COLOUMN 1 *******************************/ #hs_cos_wrapper_widget_1700166755361 .c1 .img-hover-overlay { background-color: rgba(0, 0, 0, 0.40); } #hs_cos_wrapper_widget_1700166755361 .c1 .hhs-img-hover-con:hover .img-hover-overlay { background-color: rgba(51, 71, 91, 0.80); } /******************************* END *******************************/ /******************************* COLOUMN 2 *******************************/ #hs_cos_wrapper_widget_1700166755361 .c2 .img-hover-overlay { background-color: rgba(0, 0, 0, 0.40); } #hs_cos_wrapper_widget_1700166755361 .c2 .hhs-img-hover-con:hover .img-hover-overlay { background-color: rgba(51, 71, 91, 0.80); } /******************************* END *******************************/ /******************************* COLOUMN 3 *******************************/ #hs_cos_wrapper_widget_1700166755361 .c3 .img-hover-overlay { background-color: rgba(0, 0, 0, 0.40); } #hs_cos_wrapper_widget_1700166755361 .c3 .hhs-img-hover-con:hover .img-hover-overlay { background-color: rgba(51, 71, 91, 0.80); } /******************************* END *******************************/ /******************************* COLOUMN 4 *******************************/ #hs_cos_wrapper_widget_1700166755361 .c4 .img-hover-overlay { background-color: rgba(0, 0, 0, 0.40); } #hs_cos_wrapper_widget_1700166755361 .c4 .hhs-img-hover-con:hover .img-hover-overlay { background-color: rgba(51, 71, 91, 0.80); } </style> <style> /******************************* ROW STYLE *******************************/ #hs_cos_wrapper_widget_1699382076439 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px;background-repeat: no-repeat; background-size: cover; background-position: left center;} @media (max-width: 768px) { #hs_cos_wrapper_widget_1699382076439 .hhs-text-mod { padding-top: 50px; padding-bottom: 50px; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1699382076439 .hhs-text-mod { padding-top: 25px; padding-bottom: 25px; } } /* VIDEO BACKGROUND *//* PARALLAX */ /* HERO OVERLAY COLOR *//* OUTER/INNER SHADOW *//* PULL UP ROW *//* WAVE *//******************************* END *******************************/ /******************************* COLUMN 1 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text li, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h1, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h2,#hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h3, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h4, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h5, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text h6, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text p, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text span, #hs_cos_wrapper_widget_1699382076439 .c1 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL *//******************************* END *******************************/ /******************************* COLUMN 2 *******************************/ /* TEXT STYLES */ #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text,#hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h1, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h2,#hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h3, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h4, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h5, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h6, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text p, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text span, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text li, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text blockquote {text-align: left; }@media (max-width: 992px) { #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h1, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h2,#hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h3, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h4, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h5, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h6, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text p, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text span, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text li { text-align: left; } } @media (max-width: 575px) { #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h1, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h2,#hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h3, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h4, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h5, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text h6, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text p, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text span, #hs_cos_wrapper_widget_1699382076439 .c2 .hhs-rich-text li { text-align: left; } } /* BACKGROUND *//* SPACING *//* PULL UP CONTENT OPTION *//* FORM STYLE *//* DIVIDER *//* VERTICAL ALIGN *//* MODAL */ /******************************* END *******************************/ /******************************* COLUMN 3 *******************************/ /******************************* END *******************************/ /******************************* COLUMN 4 *******************************/ /******************************* END *******************************/ </style> <link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/module_assets/67809022727/1732114032547/module_67809022727_VERIS_-_Resource_Cards.min.css"> <link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/template_assets/63711572801/1726675701602/VERISTAT-CLEAN-2022/css/modules/item-spacer.min.css"> <link rel="stylesheet" href="https://www.veristat.com/hs-fs/hub/1333476/hub_generated/module_assets/63711697505/1642002013619/module_63711697505_CLEAN_-_Item_-_Spacer.min.css"> <style> /******************************* STYLE *******************************/ #hs_cos_wrapper_widget_1647549939033 .hhs-spacer-mod { background-color: rgba(255, 255, 255, 0.0); } #hs_cos_wrapper_widget_1647549939033 .hhs-horz-spacer { height:50px; } #hs_cos_wrapper_widget_1647549939033 .hhs-horz-spacer.divider-line { margin:50px 0 50px; border-bottom: 1px solid rgba(221, 221, 221, 1); } /** TABLET CSS **/ @media (max-width: 768px) { #hs_cos_wrapper_widget_1647549939033 .hhs-horz-spacer { height:50px; } #hs_cos_wrapper_widget_1647549939033 .hhs-horz-spacer.divider-line { margin:50px 0 50px; } } /** MOBILE CSS **/ @media (max-width: 575px) { #hs_cos_wrapper_widget_1647549939033 .hhs-horz-spacer { height:50px; } #hs_cos_wrapper_widget_1647549939033 .hhs-horz-spacer.divider-line { margin:50px 0 50px; } } </style> <style> @font-face { font-family: "Lato"; font-weight: 300; font-style: normal; font-display: swap; src: url("/_hcms/googlefonts/Lato/300.woff2") format("woff2"), url("/_hcms/googlefonts/Lato/300.woff") format("woff"); } @font-face { font-family: "Lato"; font-weight: 400; font-style: normal; font-display: swap; src: url("/_hcms/googlefonts/Lato/regular.woff2") format("woff2"), url("/_hcms/googlefonts/Lato/regular.woff") format("woff"); } @font-face { font-family: "Lato"; font-weight: 700; font-style: normal; font-display: swap; src: url("/_hcms/googlefonts/Lato/700.woff2") format("woff2"), url("/_hcms/googlefonts/Lato/700.woff") format("woff"); } </style>  <style id="hs_editor_style" type="text/css"> .dnd_area-row-0-force-full-width-section > .row-fluid { max-width: none !important; } .dnd_area-row-1-max-width-section-centering > .row-fluid { max-width: 1140px !important; margin-left: auto !important; margin-right: auto !important; } .dnd_area-row-3-max-width-section-centering > .row-fluid { max-width: 1140px !important; margin-left: auto !important; margin-right: auto !important; } .dnd_area-row-4-max-width-section-centering > .row-fluid { max-width: 1100px !important; margin-left: auto !important; margin-right: auto !important; } .dnd_area-row-5-force-full-width-section > .row-fluid { max-width: none !important; } .dnd_area-row-9-force-full-width-section > .row-fluid { max-width: none !important; } .dnd_area-row-10-force-full-width-section > .row-fluid { max-width: none !important; 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display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_1647440897244-vertical-alignment > div { flex-shrink: 0 !important; } .cell_1642360209377-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_1642360209377-vertical-alignment > div { flex-shrink: 0 !important; } .cell_1699382879958-vertical-alignment { display: -ms-flexbox !important; -ms-flex-direction: column !important; -ms-flex-pack: center !important; display: flex !important; flex-direction: column !important; justify-content: center !important; } .cell_1699382879958-vertical-alignment > div { flex-shrink: 0 !important; } } /* HubSpot Styles (default) */ .dnd_area-row-0-padding { padding-top: 0px !important; padding-bottom: 0px !important; padding-left: 0px !important; padding-right: 0px !important; 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class="hhs-text-mod show-mobile show-tablet show-desktop " style=";">  <div class="gg-breadcrumb-wr">   <div class="gg-breadcrumb"> <div class="container"> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1"> <a href="/"> Home </a> >  <span style="display:none"> adaptive-designs </span> Adaptive Designs  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <p class="services">Services</p> <h2 class="services">Adaptive Design Clinical Trials</h2> <h1>Accelerate Clinical Development Success with Proven Expertise for Adaptive Clinical Trial Design, Simulation, and Execution </h1> <p>Adaptive design clinical trials are encouraged by Regulatory Agencies, including FDA, to expedite and improve efficiencies for identifying the clinical benefit of new therapies. Adaptive clinical trial designs are more complex than traditional clinical trial designs and therefore, require careful consideration, rigorous planning, and trial simulations before clinical study start-up. But, adaptive designs offer many potential benefits, such as increasing the trial's probability of success, reducing the overall time and cost of the trial, and delivering the right drug to the right patients.</p> <p><strong><span data-contrast="auto">Considering an adaptive design for your next clinical trial?   </span></strong><a href="https://www.veristat.com/contact-us"><span><strong>Let’s Talk. </strong></span></a><strong><span data-contrast="auto"> </span></strong><span data-ccp-props="{"134233279":true,"201341983":0,"335559739":0,"335559740":276}"> </span></p> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-3 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-4 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_1647484281510" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module">  <div id="" class="hhs-text-mod show-mobile show-tablet show-desktop " style=";">  <div class="gg-breadcrumb-wr">   <div class="gg-breadcrumb"> <div class="container"> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1"> <a href="/"> Home </a> >  <span style="display:none"> adaptive-designs </span> Adaptive Designs  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <h4><span style="color: #4a4a4a;">Adaptive Design Clinical Trials - Defined</span></h4> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-5 dnd_area-row-3-max-width-section-centering dnd-section dnd_area-row-3-vertical-alignment"> <div class="row-fluid "> <div class="span6 widget-span widget-type-cell cell_1642360209377-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="0" data-w="6"> <div class="row-fluid-wrapper row-depth-1 row-number-6 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1642359942501" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module">  <div id="" class="hhs-text-mod show-mobile show-tablet show-desktop " style=";">  <div class="gg-breadcrumb-wr">   <div class="gg-breadcrumb"> <div class="container"> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1"> <a href="/"> Home </a> >  <span style="display:none"> adaptive-designs </span> Adaptive Designs  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <p>Cross-functional expertise is required for the strategic planning, design, optimization, and implementation of your adaptive design. To embark on an adaptive design trial requires the ability to plan and communicate the design to the regulatory agencies and then to communicate and execute the study with the investigational sites and overall project team.  Our experts will:</p> <ul> <li>Utilize trial simulations to recommend various adaptive design options according to the disease area and company portfolio</li> <li>Develop the adaptive design protocol and outline the strategy for working with regulatory authorities</li> <li>Execute the adaptive design including trial monitoring, interim analysis, and suggesting necessary adaptations</li> <li>Provide analysis and interpretation of the adaptive trial data </li> <li>Manage the <a href="/services/medical-affairs/data-review-committees" rel="noopener">independent data monitoring committee (iDMC)</a> activities</li> </ul> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> <div class="span6 widget-span widget-type-cell dnd-column cell_1647440897244-vertical-alignment" style="" data-widget-type="cell" data-x="6" data-w="6"> <div class="row-fluid-wrapper row-depth-1 row-number-7 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1647484156143" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div id="" class="hhs-testimonial-card-mod show-mobile show-tablet show-desktop " style=";"><div class="container " style=""> <div class="row"> <div class="col-lg-12"> <div class="hhs-testimonial-card"> <div class="hhs-testimonial-content"> <blockquote>"An Adaptive Design is defined as a clinical trial design that allows for prospectively planned modifications to one or more aspects of the design based on accumulating data from subjects in the trial. "</blockquote> <h5>FDA Final 2019 Guidance</h5> <h6>Adaptive Designs for Clinical Trials of Drugs and Biologics</h6> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span></div>  </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-8 dnd-section dnd_area-row-4-max-width-section-centering dnd_area-row-4-vertical-alignment"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell cell_1699382879958-vertical-alignment dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-9 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1699384159426" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div id="" class="hhs-img-text-mod show-mobile show-tablet show-desktop "> <div class="container-fluid no-gutters"> <div class="row no-gutters"> <div class="col-lg-6 col-md-12 order-2 "> <div class="hhs-rich-text wow fadeIn " data-wow-delay="1s"> <div class="hhs-divider "> </div> <div class="hhs-rich-text-in"> <h4><span>Benefits of Adaptive Design Clinical Trials</span></h4> <ul> <li>Reduces cost, time, and required resources - reducing time to market</li> <li>Increases the chance  study success via midcourse corrections</li> <li>Mitigates risks by improving patient safety</li> <li>Facilitates better decision-making</li> </ul> <p><span></span></p> <h4><span>Considerations </span></h4> <ul> <li>Requires more intensive planning</li> <li>Commands more frequent interaction with regulatory agencies</li> <li>Improper execution can introduce bias</li> <li>Confounding can result from adaptations</li> <li>Certain adaptive designs may require larger sample sizes</li> <li>Statistical significance (alpha) penalties apply     </li> </ul> </div> </div> </div> <div class="hhs-bg-image col-lg-6 col-md-12 order-1 no-padding"> <div> <img class="hhs-reg-image wow fadeIn" src="https://www.veristat.com/hubfs/images_sizedat600px/people_working_image7.jpg" alt="adaptive deisgn clinical trial" loading="lazy" style="max-width: 100%; height: auto;"> </div> </div> </div> </div> </div>  </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-10 dnd-section dnd_area-row-5-padding dnd_area-row-5-force-full-width-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-11 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1642360381667" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module">  <div id="" class="hhs-text-mod show-mobile show-tablet show-desktop " style=";">  <div class="gg-breadcrumb-wr">   <div class="gg-breadcrumb"> <div class="container"> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1"> <a href="/"> Home </a> >  <span style="display:none"> adaptive-designs </span> Adaptive Designs  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <h4><span style="color: #4a4a4a;">Planning, Simulating, and Implementing Both Simple and Complex Adaptive  Design Clinical Trials</span></h4> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-12 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1699377647169" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div id="" class="hhs-img-hover show-mobile show-tablet show-desktop " style=";"><div class="container " style=""> <div class="row "> <div class="col-lg-6 col-md-6 col-sm-12 c1 card-col"> <div class="hhs-img-hover-con"> <div class="hhs-img-hover-front c1"> <h4><span style="color: #ffffff;">Simple Adaptive Design Types</span></h4> </div> <div class="hhs-img-hover-back c1"> <p><span style="color: #ffffff;">› Group-Sequential Design (GSD)</span><br><span style="color: #ffffff;">› Sample Size Re-Estimation (SSR)</span><br><span style="color: #ffffff;">› Adaptive Dose-Escalation Design (ADED)</span></p> </div> <div class="img-hover-overlay"></div> <img class="hhs-hover-img wow fadeIn" src="https://www.veristat.com/hubfs/images_sizedat600px/dna_molecules_blueonly.jpg" alt="simple adaptive clinical trial designs" loading="lazy" style="max-width: 100%; height: auto;"> </div> </div> <div class="col-lg-6 col-md-6 col-sm-12 c2 card-col"> <div class="hhs-img-hover-con"> <div class="hhs-img-hover-front c2"> <h4><span style="color: #ffffff;">Complex Adaptive Design Types</span></h4> </div> <div class="hhs-img-hover-back c2"> <p><span style="color: #ffffff;">› Adaptive Dose-Finding</span><br><span style="color: #ffffff;">› Adaptive Randomization Design</span><br><span style="color: #ffffff;">› Dropping Treatment Arm</span><br><span style="color: #ffffff;">(or Pick-the-Winner Design)</span><br><span style="color: #ffffff;">› Seamless Phase I/II or II/III Design</span><br><span style="color: #ffffff;">› Population Enrichment Design</span><br><span style="color: #ffffff;">(aka adaptive enrichment, biomarker-driven design)</span></p> </div> <div class="img-hover-overlay"></div> <img class="hhs-hover-img wow fadeIn" src="https://www.veristat.com/hubfs/images_sizedat600px/dna_molecules_yellowblue.jpg" alt="complex adaptive clinical trial designs" loading="lazy" style="max-width: 100%; height: auto;"> </div> </div> </div> </div> <span class="hhs-row-overlay"></span></div>   </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-13 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1647483668900" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div id="widget_1647483668900" class="horizontal-timeline"> <div class="page-center"> <div class="timeline__title"> <h4 style="text-align: center;">Planning Adaptive Design  Clinical Trials</h4> <p style="text-align: center;"><span>Expertise from start to finish</span></p> </div> <div class="horizontal-flex-parent "> <div class="horizontal-input-flex-container " style="width:380px;"> <div class="horizontal-input active "> <span data-year="" data-info="PLAN"> </span> </div> <div class="horizontal-input "> <span data-year="" data-info="DESIGN"> </span> </div> <div class="horizontal-input "> <span data-year="" data-info="SIMULATE"> </span> </div> <div class="horizontal-input "> <span data-year="" data-info="IMPLEMENT"> </span> </div> </div> <div class="horizontal-description-flex-container"> <div class="desc-div active"><h3>PLAN</h3> <p>Establish adaptive trial goals and outline the strategy for working with regulatory authorities</p></div> <div class="desc-div "><h3>DESIGN</h3> <p>Develop the adaptive design methodology and design the protocol accordingly</p></div> <div class="desc-div "><h3>SIMULATE</h3> <p>Utilize trial simulations to recommend various adaptive design options according to the disease area and company portfolio</p></div> <div class="desc-div "><h3>IMPLEMENT</h3> <p>Execute the adaptive design trial - inclusive of trial monitoring, interim analysis, and making necessary adaptations. Provide final analysis and interpretation of the trial data.</p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-14 dnd_area-row-6-background-gradient dnd-section dnd_area-row-6-background-layers"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-15 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_module_1647460878802" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module">  <div id="" class="hhs-text-mod show-mobile show-tablet show-desktop " style=";">  <div class="gg-breadcrumb-wr">   <div class="gg-breadcrumb"> <div class="container"> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1"> <a href="/"> Home </a> >  <span style="display:none"> adaptive-designs </span> Adaptive Designs  </div> </div> </div> </div> </div> <div class="container " style=""> <div class="row"> <div data-wow-delay="none" class="wow none col-sm-12 c1 "> <div class="col-inner"> <div class="hhs-rich-text-in"> <div class="hhs-rich-text"> <h2><span>When to Consider Adaptive Designs for Clinical Trials</span></h2> <p>While adaptive designs can be advantageous in certain circumstances, they are not suited for every clinical trial. Adaptive designs are highly encouraged for clinical trials in the following applications:</p> </div> </div> </div> </div> </div> </div> <span class="hhs-row-overlay"></span> </div>      </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-16 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-17 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1700166755361" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div id="" class="hhs-img-hover show-mobile show-tablet show-desktop " style=";"><div class="container " style=""> <div class="row "> <div class="col-lg-4 col-sm-12 c1 card-col"> <div class="hhs-img-hover-con"> <div class="hhs-img-hover-front c1"> <h4><span style="color: #ffffff;">Oncology Trials</span></h4> </div> <div class="hhs-img-hover-back c1"> <p><span style="color: #ffffff;">Particularly in early-phase dose-finding trial designs that use intermediate or accelerated approval endpoints for decision-making.</span></p> </div> <div class="img-hover-overlay"></div> <img class="hhs-hover-img wow fadeIn" src="https://www.veristat.com/hubfs/images_sizedat600px/therapeutic_cancer_image12.jpg" alt="oncology cancer adaptive design clinical trials" loading="lazy" style="max-width: 100%; height: auto;"> </div> </div> <div class="col-lg-4 col-sm-12 c2 card-col"> <div class="hhs-img-hover-con"> <div class="hhs-img-hover-front c2"> <h4><span style="color: #ffffff;">Rare Disease Trials</span></h4> </div> <div class="hhs-img-hover-back c2"> <p><span style="color: #ffffff;">Limited patient populations can use supplemental data from earlier run trials, disease progression analytical models, or previous adult trials.</span></p> </div> <div class="img-hover-overlay"></div> <img class="hhs-hover-img wow fadeIn" src="https://www.veristat.com/hubfs/images_sizedat600px/therapeutic_image9.jpg" alt="rare disease adaptive design clinical trials" loading="lazy" style="max-width: 100%; height: auto;"> </div> </div> <div class="col-lg-4 col-sm-12 c3 card-col"> <div class="hhs-img-hover-con"> <div class="hhs-img-hover-front c3"> <h4><span style="color: #ffffff;">Trials with Cardio Risk</span></h4> </div> <div class="hhs-img-hover-back c3"> <p><span style="color: #ffffff;">Used for safety monitoring to leverage control patients from other sources.</span></p> </div> <div class="img-hover-overlay"></div> <img class="hhs-hover-img wow fadeIn" src="https://www.veristat.com/hubfs/images_sizedat600px/therapeutic_Heart_Failure_image3.jpg" alt="adaptive design clinical trials to minimize cardiovascular risk" loading="lazy" style="max-width: 100%; height: auto;"> </div> </div> </div> </div> <span class="hhs-row-overlay"></span></div>   </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-18 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-19 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1699382076439" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module">  <div id="" class="hhs-text-mod show-mobile show-tablet show-desktop " style="background-image: url('https://www.veristat.com/hubfs/CTA-BKGRD-02a.jpg');">  <div class="gg-breadcrumb-wr">   <div 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