Leslie Benet, PhD · School of Pharmacy

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srcset="/sites/pharmacy.ucsf.edu/files/styles/pharmacy_square_half/public/person/photo/rs31962_20230206_1_0010.jpg?itok=0vollAhj&timestamp=1678401822 1x, /sites/pharmacy.ucsf.edu/files/styles/pharmacy_square_0_75x/public/person/photo/rs31962_20230206_1_0010.jpg?itok=nQcEd5XB&timestamp=1678401822 2x" media="(min-width: 431px) and (max-width: 480px)" /> <source srcset="/sites/pharmacy.ucsf.edu/files/styles/pharmacy_square_third/public/person/photo/rs31962_20230206_1_0010.jpg?itok=-4lcaFh2&timestamp=1678401822 1x, /sites/pharmacy.ucsf.edu/files/styles/pharmacy_square_0_75x/public/person/photo/rs31962_20230206_1_0010.jpg?itok=nQcEd5XB&timestamp=1678401822 2x, /sites/pharmacy.ucsf.edu/files/styles/pharmacy_square_1x/public/person/photo/rs31962_20230206_1_0010.jpg?itok=Q9aGL0_Y&timestamp=1678401822 3x" media="(min-width: 0px) and (max-width: 430px)" />  <img src="/sites/pharmacy.ucsf.edu/files/styles/pharmacy_square_third/public/person/photo/rs31962_20230206_1_0010.jpg?itok=-4lcaFh2&timestamp=1678401822" alt="Benet." title="" /> </picture> <div class="field field-name-field-image-credit-term field-type-taxonomy-term-reference field-label-hidden"> <div class="field-items"> <div class="field-item even"><a href="https://elisabeth-fall.squarespace.com/" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Elisabeth Fall</a></div> </div> </div> </div> </div> </div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-person-email" > <div class="pane-content"> <div class="field field-name-field-person-email field-type-email field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/cdn-cgi/l/email-protection#dab6bfa9b6b3bff4b8bfb4bfae9aafb9a9bcf4bfbeaf"><span class="__cf_email__" data-cfemail="98f4fdebf4f1fdb6fafdf6fdecd8edfbebfeb6fdfced">[email protected]</span></a></div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-7" > <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_7 view-dom-id-8a7c38d5867587d0668b8a7185d856e3"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <div class="views-field views-field-field-campus-phone"> <div class="field-content">Phone: +1 415 476-3853</div> </div> <div class="views-field views-field-field-person-fax"> <div class="field-content">Fax: +1 415 476-8887</div> </div> </div> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-token pane-node-field-person-address-postal" > <div class="pane-content"> <div class="street-block"><div class="thoroughfare">513 Parnassus Avenue, MSB, Rm 822B</div> <div class="premise">UCSF Box 0912</div></div> <div class="addressfield-container-inline locality-block country-US"><span class="locality">San Francisco</span>, <span class="state">CA</span> <span class="postal-code">94143</span></div> <span class="country">United States</span> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-12" > <h2 class="pane-title">Links</h2> <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_12 view-dom-id-d64edaef65bb77cf1c4b94a082ae9b1e"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <span class="views-field views-field-field-person-links"> <span class="field-content"><a href="http://pharm.ucsf.edu/benet/" target="_blank">Benet Lab</a></span> </span> <span class="views-field views-field-field-profiles-link"> <span class="field-content"><a href="https://profiles.ucsf.edu/leslie.benet">UCSF Profiles</a></span> </span> </div> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-24" > <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_24 view-dom-id-1399de6da70fb1e15d94f2d84ca1c4df"> <div class="view-content"> <div> <h2>Affiliations</h2> </div> </div> <div class="view-footer"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_16 view-dom-id-c2ea52ca696d9b2a58c093ddfe5f6c5d"> <div class="view-header"> <h3>Joint appointments</h3> </div> <div class="view-content"> <div class="views-row views-row-1"> Professor, <a href="http://pharmchem.ucsf.edu/">Department of Pharmaceutical Chemistry</a> </div> </div> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_18 view-dom-id-a7827c02473787b1dd4830a53778e83a"> <div class="view-header"> <h3>Education programs</h3> </div> <div class="view-content"> <div class="views-row views-row-1"> <a href="https://pspg.ucsf.edu">Pharmaceutical Sciences and Pharmacogenomics Graduate Program (PSPG)</a> </div> </div> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_19 view-dom-id-89889525d446f63ca0f11b484f06a7ee"> <div class="view-header"> <h3>UCSF centers, institutes, and research programs</h3> </div> <div class="view-content"> <div class="views-row views-row-1"> <a href="http://livercenter.ucsf.edu/">UCSF Liver Center</a> </div> <div class="views-row views-row-2"> <a href="https://ctsi.ucsf.edu/">Clinical and Translational Science Institute (CTSI)</a> </div> </div> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_20 view-dom-id-1a59339ccd61f0770c19479c130f31aa"> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_21 view-dom-id-d3b4504834e8704bb525d2d501fc2ec8"> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_22 view-dom-id-f6b0b938864616d97b1f9c3ac83f3e02"> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_23 view-dom-id-c6a53b15483364f891363db162e4307c"> <div class="view-header"> <h3>External affiliations</h3> </div> <div class="view-content"> <div class="views-row views-row-1"> Visiting Professor, Peking University </div> <div class="views-row views-row-2"> Visiting Professor, Zhengzhou University, Henan Province, China </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="moscone-column-content-region moscone-content panel-panel"> <div class="moscone-column-content-region-inner moscone-content-inner panel-panel-inner"> <div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-8 pane-float-left-fifty-departmental-research-area pane-float-left-fifty" > <h2 class="pane-title">Departmental research area</h2> <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_8 view-dom-id-669f0837d0a880d8060f4de87e0ee3c3"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <div class="views-field views-field-field-research-area"> <div class="field-content"><a href="https://bts.ucsf.edu/research/drug-development-regulatory-sciences">drug development and regulatory sciences</a></div> </div> </div> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-token pane-node-field-person-dept-expertise-spec pane-float-left-fifty-my-research-expertise pane-float-left-fifty" > <h2 class="pane-title">My research expertise</h2> <div class="pane-content"> pharmacokinetics, pharmacodynamics, pharmacogenomics, drug transporters, drug metabolism, drug-drug interactions, biopharmaceutics, drug delivery, enzymes and transporters, biopharmaceutics classification system (BCS), biopharmaceutics drug disposition classification system (BDDCS) </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-14" > <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_14 view-dom-id-00e0e347ba107d9a4c09d47b23c29a59"> <div class="view-content"> <div> <h2>Professional background</h2> </div> </div> <div class="view-footer"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_2 view-dom-id-9fc52fdcfe457c0b3b3872ac8e12058e"> <div class="view-header"> <h3>Degrees</h3> </div> <div class="view-content"> <div class="views-row views-row-1"> PhD, Pharmaceutical Chemistry, University of California, San Francisco </div> <div class="views-row views-row-2"> MS, Pharmaceutical Chemistry, University of Michigan </div> <div class="views-row views-row-3"> BS, Pharmacy, University of Michigan </div> <div class="views-row views-row-4"> BA, English, University of Michigan </div> </div> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_13 view-dom-id-1db05704bb48c88dcdcda241839e3d81"> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_15 view-dom-id-d32003d314bce04459902c7d422c5be4"> </div><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_17 view-dom-id-5b582b156eb1ebd61625410ad7e67bd1"> </div> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-entity-field pane-node-field-person-research-biography" > <h2 class="pane-title">Biography</h2> <div class="pane-content"> <div class="field field-name-field-person-research-biography field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Dr. Benet, Professor and former Chairman (1978-1998), Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, received his A.B. (English), B.S. (Pharmacy), M.S. from the University of Michigan and Ph.D. from the University of California. He has received nine honorary doctorates: Uppsala University, Sweden (Pharm.D., 1987), Leiden University, The Netherlands (Ph.D., 1995), University of Illinois at Chicago (D.Sc., 1997), Philadelphia College of Pharmacy and Science (D.Sc., 1997), Long Island University (D.Sc., 1999), University of Athens, Greece (Ph.D., 2005), Catholic University of Leuven, Belgium (Ph.D., 2010), University of Michigan (D.Sc., 2011) and University of Lisbon, Portugal (Ph.D., 2016). His research interests, more than 620 publications, 7 books and 12 patents are in the areas of pharmacokinetics, biopharmaceutics, drug delivery and pharmacodynamics. Dr. Benet is listed by Clarivate Analytics as one of the most highly cited pharmacologists worldwide with his published peer-reviewed papers cited over 33,000 times, while Google Scholar credits him with over 50,000 citations. His most recent work has addressed the deficiencies of in vitro-in vivo extrapolation (IVIVE) and different approaches to advancing our understanding and prediction of clearance processes. Dr. Benet was a Founder/Editor of the JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS (1973-98) and Associate Editor of PHARMACOLOGY AND THERAPEUTICS (1995-2000). He presently serves a member of the Editorial boards of PHARMACOLOGY and AAPS JOURNAL. He is a Fellow of the American Association for the Advancement of Science (AAAS), the American Association of Pharmaceutical Scientists (AAPS), the American College of Clinical Pharmacology (ACCP) and the Controlled Release Society (CRS). In 1982, Dr. Benet received the APhA Academy of Pharmaceutical Sciences (APS) Research Achievement Award in Pharmaceutics and the University of Michigan, College of Pharmacy, Distinguished Alumnus Award. In 1985, he served as President of APS. During 1986, Dr. Benet was a Founder and first President of the AAPS. In 1987, Dr. Benet was elected to membership in the National Academy of Medicine (NAM) of the U.S. National Academy of Sciences. In 1988, he received the ACCP Distinguished Service Award and in 1989, the AAPS Distinguished Pharmaceutical Scientist Award. In 1990, he was the recipient of the Rho Chi Lecture Award, and the UCSF Long Teaching Award, while in 1991, he received the Volwiler Research Achievement Award of the American Association of Colleges of Pharmacy (AACP). In 1993-94, he served as AACP President. In 1995, he received the Rawls-Palmer Progress in Medicine Award of the American Society for Clinical Pharmacology and Therapeutics (ASCPT); in 1996, the AAPS Distinguished Service Award; and in 2000 the APhA Takeru Higuchi Research Prize and the AAPS Wurster Research Award in Pharmaceutics. In 2001 he was awarded the Høst-Madsen Medal of the International Pharmaceutical Federation (FIP) and the UCSF Outstanding Faculty Mentorship Award (repeated in 2016). In 2004, he was awarded the Pharmaceutical Sciences World Congress Research Achievement Award and the CRS Career Achievement in Oral Drug Delivery Award. In 2007 he was selected as the UCSF Distinguished Clinical Research Lecturer; in 2010, the ASCPT Hunter Memorial Award in Therapeutics; and in 2011 the ACCP Distinguished Investigator award. In 2012, the September issue of PHARMACEUTICAL RESEARCH was dedicated in his honor and he was made an honorary member of FIP. In 2013, he was awarded the APhA Ebert Prize, the AAPS Journal Outstanding Manuscript award and the September issue of JOURNAL OF PHARMACEUTICAL SCIENCES was dedicated in his honor. In 2015 he received the ISSX North American Scientific Achievement award; in 2016 the Remington Honor Medal from the APhA, the highest honor in American Pharmacy; and in 2017 a full day symposium in his honor entitled “The Cutting Edge in Pharmaceutical Sciences—50 Years of Progress Celebrating Les Benet’s 80th Birthday” was held in conjunction with the Pharmaceutical Sciences World Congress in Stockholm, Sweden. In 2023 he received the Lifetime Achievement Award of the Frankfurt Foundation for the Quality of Medicines. Dr. Benet formerly served as Chair of the Pharmacology Study Section and the Pharmacological Sciences Review Committee for the NIH, the FDA CBER Peer Review Committee, the FDA Expert Panel on Individual Bioequivalence, the Board of Pharmaceutical Sciences of the FIP, the Organizing Committee for the FIP Millennial World Congress of Pharmaceutical Sciences, the Congressionally mandated NAM/National Research Council (NRC) Committee on Accelerating the Research, Development and Acquisition of Medical Countermeasures Against Biological Warfare Agents and the FIP Foundation for Education and Research and as a member of the FDA Science Board, the FDA Generic Drugs Advisory Committee and the NRC Biodefense Standing Committee. He presently serves as Chair of the Board of Directors of Medicines360, a nonprofit pharmaceutical company, emphasizing products for women’s health. July 2023</p> </div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-9" > <h2 class="pane-title">Research keywords</h2> <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_9 columns-3 view-dom-id-377165959c55155bfa38485ba61e5205"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <div class="views-field views-field-field-person-keywords-profiles"> <div class="field-content"><div class="item-list"><ul><li class="first">Hepatocytes</li> <li>Cytochrome P-450 CYP3A</li> <li>Cyclosporine</li> <li>biopharmaceutics</li> <li>Nitroglycerin</li> <li>Intestinal Absorption</li> <li>Cytochrome P-450 Enzyme System</li> <li>Metabolic Clearance Rate</li> <li>pharmacokinetics</li> <li>Microsomes, Liver</li> <li>Therapeutic Equivalency</li> <li>drug interactions</li> <li>liver</li> <li>Biological Models</li> <li class="last">Pharmaceutical Preparations</li> </ul></div></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="moscone-container moscone-footer clearfix panel-panel"> <div class="moscone-container-inner moscone-footer-inner panel-panel-inner"> <div class="panel-pane pane-block pane-quicktabs-quicktabs-pub-news-media" > <div class="pane-content"> <div id="quicktabs-quicktabs_pub_news_media" class="quicktabs-wrapper quicktabs-style-nostyle"><div class="item-list"><ul class="quicktabs-tabs quicktabs-style-nostyle"><li class="active first"><a href="/leslie-benet?qt-quicktabs_pub_news_media=0#qt-quicktabs_pub_news_media" id="quicktabs-tab-quicktabs_pub_news_media-0" class="quicktabs-tab quicktabs-tab-view quicktabs-tab-view-person-related-items-panel-pane-1 active">News</a></li> <li class="last"><a href="/leslie-benet?qt-quicktabs_pub_news_media=2#qt-quicktabs_pub_news_media" id="quicktabs-tab-quicktabs_pub_news_media-2" class="quicktabs-tab quicktabs-tab-view quicktabs-tab-view-ucsf-person-profile-panel-pane-4 active">Honors & Awards</a></li> </ul></div><div id="quicktabs-container-quicktabs_pub_news_media" class="quicktabs_main quicktabs-style-nostyle"><div id="quicktabs-tabpage-quicktabs_pub_news_media-0" class="quicktabs-tabpage "><div class="view view-person-related-items view-id-person_related_items view-display-id-panel_pane_1 view-dom-id-0ee784289252e30d10a64c67702092e5"> <div class="view-content"> <table class="views-table cols-0"> <tbody> <tr class="odd views-row-first"> <td class="views-field views-field-counter"> 1. </td> <td class="views-field views-field-title"> <a href="/news/2024/07/school-pharmacy-celebrates-global-drug-development-regulatory-science-collaboration">School of Pharmacy celebrates global drug development and regulatory science collaboration</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 2. </td> <td class="views-field views-field-title"> <a href="/news/2024/05/benet-honored-symposium-endowed-professorship">Benet honored in symposium with endowed professorship</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 3. </td> <td class="views-field views-field-title"> <a href="/news/2023/09/update-dean-putting-plans-action">Update from the Dean: Putting plans in action</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 4. </td> <td class="views-field views-field-title"> <a href="/news/2023/04/benet-earns-lifetime-achievement-award-frankfurt-foundation-quality-medicines">Benet earns Lifetime Achievement Award from Frankfurt Foundation Quality of Medicines</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 5. </td> <td class="views-field views-field-title"> <a href="/news/2017/02/koda-kimble-seed-award-recipients-explore-blue-sky-projects">Koda-Kimble Seed Award recipients explore ‘blue-sky’ projects</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 6. </td> <td class="views-field views-field-title"> <a href="/news/2016/07/30th-annual-course-pharmacokinetics-pharmaceutical-scientists">30th annual course on Pharmacokinetics for Pharmaceutical Scientists</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 7. </td> <td class="views-field views-field-title"> <a href="/news/2016/06/update-dean-springsummer-2016">Update from the Dean - Spring/Summer 2016</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 8. </td> <td class="views-field views-field-title"> <a href="/news/2016/01/benet-receives-remington-honor-medal-highest-award-pharmacy">Benet receives Remington Honor Medal, highest award in pharmacy</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 9. </td> <td class="views-field views-field-title"> <a href="/news/2015/11/update-dean-fallwinter-2015">Update from the Dean - Fall/Winter 2015</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 10. </td> <td class="views-field views-field-title"> <a href="/news/2015/09/benet-receive-issx-north-american-scientific-achievement-award">Benet to receive ISSX North American Scientific Achievement Award</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 11. </td> <td class="views-field views-field-title"> <a href="/news/2015/06/history-event-highlights-school-innovations-research-practice-education">History event highlights School innovations in research, practice, education</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 12. </td> <td class="views-field views-field-title"> <a href="/news/2013/02/benet-wins-ebert-prize">Benet wins Ebert Prize</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 13. </td> <td class="views-field views-field-title"> <a href="/news/2013/02/update-dean-winter-2013">Update from the Dean - Winter 2013</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 14. </td> <td class="views-field views-field-title"> <a href="/news/2012/11/update-dean-fall-2012">Update from the Dean - Fall 2012</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 15. </td> <td class="views-field views-field-title"> <a href="/news/2010/12/reflection-30-years-top-nih-funding-ucsf-school-pharmacy">Reflection: 30 years of top NIH funding for UCSF School of Pharmacy</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 16. </td> <td class="views-field views-field-title"> <a href="/news/2010/04/benet-honored-lifetime-accomplishments-drug-clearance-research-discovery">Benet honored for lifetime accomplishments in drug clearance research and discovery</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 17. </td> <td class="views-field views-field-title"> <a href="/news/2010/03/update-dean-fallwinter-2010">Update from the Dean - Fall/Winter 2010</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 18. </td> <td class="views-field views-field-title"> <a href="/news/2010/02/symposium-future-therapeutics-inaugurates-new-ucsf-department">Symposium on the future of therapeutics inaugurates new UCSF department</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 19. </td> <td class="views-field views-field-title"> <a href="/news/2009/07/scientists-explain-how-they-are-making-therapeutics-intelligent">Scientists explain how they are making therapeutics “intelligent”</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 20. </td> <td class="views-field views-field-title"> <a href="/news/2009/03/giacomini-peck-honored-ascpt-awards">Giacomini and Peck honored with ASCPT awards</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 21. </td> <td class="views-field views-field-title"> <a href="/news/2009/03/update-dean-fallwinter-2009">Update from the Dean - Fall/Winter 2009</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 22. </td> <td class="views-field views-field-title"> <a href="/news/2009/02/ucsf-helps-launch-chinese-course-drug-development">UCSF helps launch Chinese course on drug development</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 23. </td> <td class="views-field views-field-title"> <a href="/news/2008/12/benet-receives-magic-bullet-lifetime-achievement-award">Benet receives Magic Bullet Lifetime Achievement Award</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 24. </td> <td class="views-field views-field-title"> <a href="/news/2008/12/drug-development-course-teaches-professionals-see-bigger-picture">Drug development course teaches professionals to see bigger picture</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 25. </td> <td class="views-field views-field-title"> <a href="/news/2007/10/benet-delivers-distinguished-lecture">Benet delivers distinguished lecture</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 26. </td> <td class="views-field views-field-title"> <a href="/news/2007/08/update-dean-springsummer-2007">Update from the Dean - Spring/Summer 2007</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 27. </td> <td class="views-field views-field-title"> <a href="/news/2006/09/hale-named-macarthur-fellow">Hale named MacArthur Fellow</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 28. </td> <td class="views-field views-field-title"> <a href="/news/2004/07/giacomini-benet-honored-international-peers">Giacomini and Benet honored by international peers</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 29. </td> <td class="views-field views-field-title"> <a href="/news/2004/07/update-dean-july-2004">Update from the Dean - July 2004</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 30. </td> <td class="views-field views-field-title"> <a href="/news/2003/12/leslie-z-benet-named-thomson-isi-highly-cited-researcher">Leslie Z. Benet named Thomson ISI Highly Cited Researcher</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 31. </td> <td class="views-field views-field-title"> <a href="/news/2003/12/about-maya-leabman-more-news">About Maya Leabman, and more news</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 32. </td> <td class="views-field views-field-title"> <a href="/news/2002/07/update-dean-july-2002">Update from the Dean - July 2002</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 33. </td> <td class="views-field views-field-title"> <a href="/news/2002/06/about-claire-lee-more-news">About Claire Lee, and more news</a> </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 34. </td> <td class="views-field views-field-title"> <a href="/news/2001/10/joanne-whitney-dpsl-more-news">Joanne Whitney and the DPSL, and more news</a> </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 35. </td> <td class="views-field views-field-title"> <a href="/news/2001/07/parfitt-pattie-appointed-director-development-more-news">Parfitt Pattie appointed director of development, and more news</a> </td> </tr> <tr class="even views-row-last"> <td class="views-field views-field-counter"> 36. </td> <td class="views-field views-field-title"> <a href="/news/2001/05/giacomini-featured-time-magazine-more-news">Giacomini featured in Time magazine, and more news</a> </td> </tr> </tbody> </table> </div> </div></div><div id="quicktabs-tabpage-quicktabs_pub_news_media-2" class="quicktabs-tabpage quicktabs-hide"><div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_4 view-dom-id-0f0db03d0b4c8326cc02181fbf5db4ec"> <div class="view-content"> <table class="views-table cols-0"> <tbody> <tr class="odd views-row-first"> <td class="views-field views-field-counter"> 1. </td> <td class="views-field views-field-field-profiles-honors-awards"> Remington Honor Medal, American Pharmacists Association, 2016 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 2. </td> <td class="views-field views-field-field-profiles-honors-awards"> Doctor of Philosophy, honoris causa, University of Lisbon, Portugal, 2016 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 3. </td> <td class="views-field views-field-field-profiles-honors-awards"> William B. Abrams Lectureship, FDA/CDER and ASCPT, 2015 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 4. </td> <td class="views-field views-field-field-profiles-honors-awards"> William B. Abrams Lectureship, FDA/CDER and American Society for Clinical Pharmacology and Therapeutics, 2015 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 5. </td> <td class="views-field views-field-field-profiles-honors-awards"> North American Scientific Achievement Award, International Society for the Study of Xenobiotics, 2015 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 6. </td> <td class="views-field views-field-field-profiles-honors-awards"> "25 Top Pharmacy Professors" in USA, Medical Technology Schools, 2015 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 7. </td> <td class="views-field views-field-field-profiles-honors-awards"> Listed among "25 Top Pharmacy Professors" in the U.S.A., Medical Technology Schools, 2015 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 8. </td> <td class="views-field views-field-field-profiles-honors-awards"> Guest Professorship, Sichuan University, Sichuan Province, China, 2014-2019 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 9. </td> <td class="views-field views-field-field-profiles-honors-awards"> 1 of 16 pharmacologists worldwide to be listed in both 2001 and 2014 compilations, Thompson Reuters Highly Cited Researcher, 2014 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 10. </td> <td class="views-field views-field-field-profiles-honors-awards"> Highly cited Researcher-Pharmacology, Thomson Reuters, 2014 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 11. </td> <td class="views-field views-field-field-profiles-honors-awards"> AAPS Journal Manuscript Award for the Most Outstanding Manuscript, American Association of Pharmaceutical Scientists, 2013 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 12. </td> <td class="views-field views-field-field-profiles-honors-awards"> 2013 APhA-APRS Ebert Prize, American Pharmacists Association Academy of Pharmaceutical Research and Science (APhA-APRS),, 2013 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 13. </td> <td class="views-field views-field-field-profiles-honors-awards"> Busse Lecture, University of Wisconsin, 2013 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 14. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Plenary Lecture, CPSA Shanghai 2012: From Bench to Decision Making – From Basics to Applications, Shanghai, China, 2012 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 15. </td> <td class="views-field views-field-field-profiles-honors-awards"> Honorary Member, Chinese Society of Clinical Pharmacy, Zhengzhou, China, 2012 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 16. </td> <td class="views-field views-field-field-profiles-honors-awards"> Honorary Member, International Pharmaceutical Federation, The Netherlands, 2012 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 17. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Plenary Lecture, International Symposium on Past, Present and Future Molecular Pharmacokinetics, Tokyo, Japan, 2012 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 18. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Keynote Lecture, NRPB – AAPS Workshop on Clinical and Diagnostic Biomarkers, Taipei, Taiwan, 2012 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 19. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Keynote Lecture, Texas Tech University Health Science Center School of Pharmacy Research Days, Texas Tech University, 2012 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 20. </td> <td class="views-field views-field-field-profiles-honors-awards"> Visiting Professor of the First Clinical Medical College of Zhengzhou University, and the Institute, Zhengzhou University, Henan Province, China, 2012 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 21. </td> <td class="views-field views-field-field-profiles-honors-awards"> Distinguished Investigator Award, American College of Clinical Pharmacology, 40th Annual Meeting, Chicago, IL, 2011 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 22. </td> <td class="views-field views-field-field-profiles-honors-awards"> The AstraZeneca Drug Hunting Lecture, AstraZeneca Research & Development Mölndal, Sweden, 2011 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 23. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Plenary Lecture, Symposium, Biomedical Centre, Uppsala University, Uppsala, Sweden, 2011 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 24. </td> <td class="views-field views-field-field-profiles-honors-awards"> Inaugural Albert B. Prescott Distinguished Lecture, Horace Rackham School of Graduate Studies, University of Michigan, 2011 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 25. </td> <td class="views-field views-field-field-profiles-honors-awards"> Named “National Associate”, National Research Council, 2011 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 26. </td> <td class="views-field views-field-field-profiles-honors-awards"> Gerhard Levy Distinguished Lectureship in Pharmaceutical Sciences, State University of New York at Buffalo, 2011 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 27. </td> <td class="views-field views-field-field-profiles-honors-awards"> Doctor of Science, honoris causa, University of Michigan, 2011 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 28. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Plenary Lecture, 18th International Symposium on Microsomes and Drug Oxidations, Beijing, China, 2010 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 29. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Plenary Lecture, 2010 Pharmaceutical Sciences World Congress and the AAPS Annual Meeting and Exposition, New Orleans,, 2010 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 30. </td> <td class="views-field views-field-field-profiles-honors-awards"> Oscar B. Hunter Memorial Award in Therapeutics, American Society for Clinical Pharmacology and Therapeutics 111th Annual Meeting, Atlanta, Georgia, 2010 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 31. </td> <td class="views-field views-field-field-profiles-honors-awards"> Doctor of Philosophy, honoris causa, Catholic University of Leuven, Leuven, Belgium, 2010 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 32. </td> <td class="views-field views-field-field-profiles-honors-awards"> Elected Fellow, Controlled Release Society, 2010 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 33. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Keynote Lecture, The 42nd Annual Pharmaceutics Graduate Student Research Meeting (PGSRM), The Ohio State University, 2010 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 34. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Plenary Lecture, 129th Annual Meeting of the Pharmaceutical Society of Japan, Kyoto, Japan, 2009 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 35. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Plenary Lecture, 9th International Symposium of the Controlled Release Society Indian Chapter, Mumbai, India, 2009 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 36. </td> <td class="views-field views-field-field-profiles-honors-awards"> Nagai Foundation Tokyo Distinguished Lectureship 2008, 2008 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 37. </td> <td class="views-field views-field-field-profiles-honors-awards"> National Defense Medical Center, Taipei, 2008 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 38. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Keynote Speaker, 100th Anniversary of School of Pharmacy, NDMC; 2008 PST & TSHP Joint International Conference, 2008 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 39. </td> <td class="views-field views-field-field-profiles-honors-awards"> Paul Ehrlich Magic-Bullet Award 2008 Lifetime Achievement, 100th Anniversary of the Nobel Prize Awarded to Paul Ehrlich, Nürnberg, Germany, 2008 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 40. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Featured Speaker, 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, 2008 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 41. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Plenary Lecture, 28th Annual Meeting of the Japanese Society for Drug Delivery Systems, Tokyo, Japan, 2008 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 42. </td> <td class="views-field views-field-field-profiles-honors-awards"> Keynote Lecture, 8th International Symposium on Advances in Technology & Business Potential of New Drug Delivery Syst, 2008 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 43. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invited Plenary Lecture, Modified Release Forum, West Point, PA, 2008 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 44. </td> <td class="views-field views-field-field-profiles-honors-awards"> Chair, Scientific Advisory Board, iMED.UL (Research Institute for Medicines and Pharmaceutical Sciences) University of Lisbon, Portuga, 2008 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 45. </td> <td class="views-field views-field-field-profiles-honors-awards"> Plenary Lecture, 7th International Symposium on Advances in Technology and Business Potential of New Drug Delivery Sy, 2007 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 46. </td> <td class="views-field views-field-field-profiles-honors-awards"> Keynote Lecture, Biocomputing Day, Division of Biocomputing, School of Medicine, University of New Mexico, 2007 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 47. </td> <td class="views-field views-field-field-profiles-honors-awards"> International Honorary Member, Japan Society for the Study of Xenobiotics, Sendai, Japan, 2007 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 48. </td> <td class="views-field views-field-field-profiles-honors-awards"> Keynote Lecture, Meeting of the European Drug Absorption Network, Leuven, Belgium, 2007 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 49. </td> <td class="views-field views-field-field-profiles-honors-awards"> UCSF 7th Distinguished Clinical Research Lecturer, University of California San Francisco, 2007 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 50. </td> <td class="views-field views-field-field-profiles-honors-awards"> Graduation Speaker, University of Michigan College of Pharmacy, Ann Arbor, MI, 2007 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 51. </td> <td class="views-field views-field-field-profiles-honors-awards"> Plenary Lecture, 16th International Symposium on Microsomes and Drug Oxidation, Budapest, 2006 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 52. </td> <td class="views-field views-field-field-profiles-honors-awards"> Plenary Lecture, 4th International COE Symposium, Target Validation, Lead Optimization & Clinical Development, Tokyo, 2006 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 53. </td> <td class="views-field views-field-field-profiles-honors-awards"> Plenary Lecture, Analytica Conference 2006, Munich, Germany, 2006 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 54. </td> <td class="views-field views-field-field-profiles-honors-awards"> Plenary Lecture, Canadian Society for Pharmaceutical Sciences 9th Annual International Symposium on Pharmaceutical Sc, 2006 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 55. </td> <td class="views-field views-field-field-profiles-honors-awards"> Chair, Gordon Research Conference on Drug Metabolism, Plymouth, NH, 2006 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 56. </td> <td class="views-field views-field-field-profiles-honors-awards"> Keynote Address, Great Lakes Symposium 2006, Buffalo, NY, 2006 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 57. </td> <td class="views-field views-field-field-profiles-honors-awards"> Plenary Lecture, Journees Galeniques de Saint-Remy de Provence, Saint-Remy, France, 2006 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 58. </td> <td class="views-field views-field-field-profiles-honors-awards"> Plenary Lecture, 2nd International Symposium on Scientific & Regulatory Aspects of Dissolution & Bioequivalence, 2005 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 59. </td> <td class="views-field views-field-field-profiles-honors-awards"> Plenary Lecture, 9th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology, 2005 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 60. </td> <td class="views-field views-field-field-profiles-honors-awards"> Keynote Address, British Pharmaceutical Conference, Manchester, UK, 2005 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 61. </td> <td class="views-field views-field-field-profiles-honors-awards"> Doctor of Philosophy, honoris causa, University of Athens, Greece, 2005 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 62. </td> <td class="views-field views-field-field-profiles-honors-awards"> Career Achievement Award in Oral Drug Delivery, Controlled Release Society 2004 Annual Meeting & Exposition, 2004 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 63. </td> <td class="views-field views-field-field-profiles-honors-awards"> Research Achievement Award in Pharmaceutical Sciences, Pharmaceutical Sciences World Congress 2004, Kyoto, 2004 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 64. </td> <td class="views-field views-field-field-profiles-honors-awards"> Opening Plenary Lecture, First Congress of the Portuguese Society for Pharmaceutical Sciences, 2003 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 65. </td> <td class="views-field views-field-field-profiles-honors-awards"> ISI Highly Cited Researcher, Institute for Scientific Information, 2003 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 66. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invested as a “Member of Honour”, Romanian Academy of Medical Sciences, 2003 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 67. </td> <td class="views-field views-field-field-profiles-honors-awards"> Chair, IOM/NRC Committee on Accelerating the Research, Development and Acquisition, of Medical Countermeasures Against Biological Warfare Agents, 2002-2004 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 68. </td> <td class="views-field views-field-field-profiles-honors-awards"> Plenary Lecture, 10th International Conference on Pharmaceutical Technology, Florence, Italy, 2002 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 69. </td> <td class="views-field views-field-field-profiles-honors-awards"> Invested as a “Miembro Honorario”, Academia de Ciencias Farmacéuticas de Chile, Santiago, Chile, 2002 </td> </tr> <tr class="even"> <td class="views-field views-field-counter"> 70. </td> <td class="views-field views-field-field-profiles-honors-awards"> Plenary Lecture, International Pharmaceutical Technology Symposium 2002, Istanbul, Turkey, 2002 </td> </tr> <tr class="odd"> <td class="views-field views-field-counter"> 71. </td> <td class="views-field views-field-field-profiles-honors-awards"> Elected Fellow, American Association of Indian Pharmaceutical Scientists, 2001 </td> </tr> <tr class="even views-row-last"> <td class="views-field views-field-counter"> 72. </td> <td class="views-field views-field-field-profiles-honors-awards"> Høst-Madsen Medal, International Pharmaceutical Federation, 2001 </td> </tr> </tbody> </table> </div> </div></div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-views-panes pane-ucsf-person-profile-panel-pane-1" > <h2 class="pane-title">Publications</h2> <div class="pane-content"> <div class="view view-ucsf-person-profile view-id-ucsf_person_profile view-display-id-panel_pane_1 view-dom-id-d2cfd58b067ebb69d25b63e286c6fe66"> <div class="view-content"> <table class="views-table cols-0"> <tbody> <tr class="odd views-row-first"> <td class="views-field views-field-field-person-publications-list"> Yu Z, Liu W, Wang Z, Chen Y, Yan J, Benet LZ, Zhai S. Is there a possibility that P-glycoprotein reduces reproductive toxicity in males but breast cancer resistance protein does not? Clin Transl Sci. 2024 Oct; 17(10):e70027. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Sodhi JK. Commentary: Pharmacokinetic Theory Must Consider Published Experimental Data. Drug Metab Dispos. 2024 Aug 14; 52(9):932-938. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Tiitto MV, Sodhi JK. The potential of developing high hepatic clearance drugs via controlled release: Lessons from Kirchhoff's Laws. J Control Release. 2024 Sep; 373:564-567. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Sodhi JK. Are all measures of liver Kpuu a function of FH, as determined following oral dosing, or have we made a critical error in defining hepatic drug clearance? Eur J Pharm Sci. 2024 May 01; 196:106753. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Wakuda H, Xiang Y, Sodhi JK, Uemura N, Benet LZ. An Explanation of Why Dose-Corrected Area Under the Curve for Alternate Administration Routes Can Be Greater than for Intravenous Dosing. AAPS J. 2024 01 30; 26(1):22. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Solubility-Permeability Interplay in Facilitating the Prediction of Drug Disposition Routes, Extent of Absorption, Food Effects, Brain Penetration and Drug Induced Liver Injury Potential. J Pharm Sci. 2023 09; 112(9):2326-2331. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Sodhi JK. The Uses and Advantages of Kirchhoff's Laws vs. Differential Equations in Pharmacology, Pharmacokinetics, and (Even) Chemistry. AAPS J. 2023 04 10; 25(3):38. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Liu W, Yu Z, Wang Z, Waubant EL, Zhai S, Benet LZ. Using an animal model to predict the effective human dose for oral multiple sclerosis drugs. Clin Transl Sci. 2023 03; 16(3):467-477. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Pachter JA, Dill KA, Sodhi JK, Benet LZ. Review of the application of Kirchhoff's Laws of series and parallel flows to pharmacology: Defining organ clearance. Pharmacol Ther. 2022 Nov; 239:108278. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Bocci G, Oprea TI, Benet LZ. State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References. AAPS J. 2022 02 23; 24(2):37. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Kameyama T, Sodhi JK, Benet LZ. Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide a Useful Improvement in In Vitro-In Vivo Extrapolation Predictability? Drug Metab Dispos. 2022 04; 50(4):401-412. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Sodhi JK. Can In Vitro-In Vivo Extrapolation Be Successful? Recognizing the Incorrect Clearance Assumptions. Clin Pharmacol Ther. 2022 05; 111(5):1022-1035. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Liu S, Sodhi JK, Benet LZ. Analyzing Potential Intestinal Transporter Drug-Drug Interactions: Reevaluating Ticagrelor Interaction Studies. Pharm Res. 2021 Oct; 38(10):1639-1644. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Burmeister Getz E, Carroll KJ, Mielke J, Jones B, Benet LZ. Batch Selection via In Vitro/In Vivo Correlation in Pharmacokinetic Bioequivalence Testing. AAPS PharmSciTech. 2021 Aug 19; 22(7):224. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Bamfo NO, Hosey-Cojocari C, Benet LZ, Remsberg CM. Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans. Pharm Res. 2021 Jul; 38(7):1139-1156. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Xiang Y, Okochi H, Kozachenko I, Sodhi JK, Frassetto LA, Benet LZ. Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers. Clin Pharmacol Ther. 2021 08; 110(2):480-485. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Sodhi JK, Makrygiorgos G, Mesbah A. There is Only One Valid Definition of Clearance: Critical Examination of Clearance Concepts Reveals the Potential for Errors in Clinical Drug Dosing Decisions. AAPS J. 2021 05 10; 23(3):67. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Kou W, Sodhi JK, Wu X, Benet LZ. Investigating Intestinal Transporter Involvement in Rivaroxaban Disposition through Examination of Changes in Absorption. Pharm Res. 2021 May; 38(5):795-801. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Okochi H, Louie A, Phung N, Zhang K, Tallerico RM, Kuncze K, Spinelli MA, Koss CA, Benet LZ, Gandhi M. Tenofovir and emtricitabine concentrations in hair are comparable between individuals on tenofovir disoproxil fumarate versus tenofovir alafenamide-based ART. Drug Test Anal. 2021 Jul; 13(7):1354-1370. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Using Individualized Patient Data for Prediction of Population Dosing Recommendations Versus Predictions of Individualized Patient Dosing. J Clin Pharmacol. 2021 06; 61(6):734-735. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Sodhi JK, Benet LZ. Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization. J Med Chem. 2021 04 08; 64(7):3546-3559. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Sodhi JK, Huang CH, Benet LZ. Volume of Distribution is Unaffected by Metabolic Drug-Drug Interactions. Clin Pharmacokinet. 2021 02; 60(2):205-222. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Sodhi JK, Liu S, Benet LZ. Intestinal Efflux Transporters P-gp and BCRP Are Not Clinically Relevant in Apixaban Disposition. Pharm Res. 2020 Sep 29; 37(10):208. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Sodhi JK. Investigating the Theoretical Basis for In Vitro-In Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways. AAPS J. 2020 09 10; 22(5):120. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Di L, Artursson P, Avdeef A, Benet LZ, Houston JB, Kansy M, Kerns EH, Lennernäs H, Smith DA, Sugano K. The Critical Role of Passive Permeability in Designing Successful Drugs. ChemMedChem. 2020 10 19; 15(20):1862-1874. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Sodhi JK, Benet LZ. The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions. AAPS J. 2020 08 17; 22(5):111. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Sodhi JK, Benet LZ. A Simple Methodology to Differentiate Changes in Bioavailability From Changes in Clearance Following Oral Dosing of Metabolized Drugs. Clin Pharmacol Ther. 2020 08; 108(2):306-315. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Sodhi JK, Wang HJ, Benet LZ. Are There Any Experimental Perfusion Data that Preferentially Support the Dispersion and Parallel-Tube Models over the Well-Stirred Model of Organ Elimination? Drug Metab Dispos. 2020 07; 48(7):537-543. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Liu W, Yan T, Chen K, Yang L, Benet LZ, Zhai S. Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System. Pharmacotherapy. 2020 04; 40(4):274-290. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Sodhi JK, Liu S, Benet LZ. Challenging the Relevance of Unbound Tissue-to-Blood Partition Coefficient (Kpuu) on Prediction of Drug-Drug Interactions. Pharm Res. 2020 Mar 25; 37(4):73. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Sun A, Benet LZ. Late-Stage Failures of Monoclonal Antibody Drugs: A Retrospective Case Study Analysis. Pharmacology. 2020; 105(3-4):145-163. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Bocci G, Benet LZ, Oprea TI. Can BDDCS illuminate targets in drug design? Drug Discov Today. 2019 12; 24(12):2299-2306. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Wang HJ, Benet LZ. Protein Binding and Hepatic Clearance: Re-Examining the Discrimination between Models of Hepatic Clearance with Diazepam in the Isolated Perfused Rat Liver Preparation. Drug Metab Dispos. 2019 12; 47(12):1397-1402. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Bowman CM, Benet LZ. In Vitro-In Vivo Inaccuracy: The CYP3A4 Anomaly. Drug Metab Dispos. 2019 12; 47(12):1368-1371. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Surofchy DD, Frassetto LA, Benet LZ. Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. Pharm Res. 2019 Sep 04; 36(11):155. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Bowman CM, Sodhi JK. How Transporters Have Changed Basic Pharmacokinetic Understanding. AAPS J. 2019 09 03; 21(6):103. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S, Benet LZ. The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats. Drug Metab Dispos. 2019 09; 47(9):1004-1012. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Bowman CM, Benet LZ. Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties. Pharm Res. 2019 May 31; 36(8):113. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Bowman CM, Koleske ML, Rinaldi CL, Sodhi JK. Understanding drug-drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs. J Pharmacokinet Pharmacodyn. 2019 04; 46(2):155-163. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Bowman CM, Benet LZ. In Vitro-In Vivo Extrapolation and Hepatic Clearance-Dependent Underprediction. J Pharm Sci. 2019 07; 108(7):2500-2504. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Kogame A, Moriya Y, Mori I, Pan L, Morohashi A, Ebihara T, Fukui H, Tagawa Y, Benet LZ. Characterization of Fasiglifam-Related Liver Toxicity in Dogs. Drug Metab Dispos. 2019 05; 47(5):525-534. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Bowman CM, Okochi H, Benet LZ. The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation. Drug Metab Dispos. 2019 04; 47(4):358-363. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Jayachandran P, Carroll KJ, Burmeister Getz E. Batch-to-Batch and Within-Subject Variability: What Do We Know and How Do These Variabilities Affect Clinical Pharmacology and Bioequivalence? Clin Pharmacol Ther. 2019 02; 105(2):326-328. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ. Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs. Clin Pharmacol Ther. 2019 02; 105(2):411-416. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR. TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):571-586. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Bowman CM, Liu S, Sodhi JK. The Extended Clearance Concept Following Oral and Intravenous Dosing: Theory and Critical Analyses. Pharm Res. 2018 Oct 22; 35(12):242. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Hysi PG, Khawaja AP, Menni C, Tamraz B, Wareham N, Khaw KT, Foster PJ, Benet LZ, Spector TD, Hammond CJ. Ascorbic acid metabolites are involved in intraocular pressure control in the general population. Redox Biol. 2019 01; 20:349-353. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gandhi M, Bacchetti P, Rodrigues WC, Spinelli M, Koss CA, Drain PK, Baeten JM, Mugo NR, Ngure K, Benet LZ, Okochi H, Wang G, Vincent M. Development and Validation of an Immunoassay for Tenofovir in Urine as a Real-Time Metric of Antiretroviral Adherence. EClinicalMedicine. 2018 Aug-Sep; 2-3:22-28. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Bowman CM, Benet LZ. An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation. Eur J Pharm Sci. 2018 Oct 15; 123:502-514. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Chan R, Benet LZ. Evaluation of the Relevance of DILI Predictive Hypotheses in Early Drug Development: Review of In Vitro Methodologies vs BDDCS Classification. Toxicol Res (Camb). 2018 May 08; 7(3):358-370. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Predicting Pharmacokinetics/Pharmacodynamics in the Individual Patient: Separating Reality From Hype. J Clin Pharmacol. 2018 Aug; 58(8):979-989. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Chan R, Benet LZ. Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI. Toxicol Sci. 2018 04 01; 162(2):499-508. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Liu W, Guan X, Yu Z, Chen K, Benet L, Zhai S. A Drug-drug Interaction Between Cyclosporine and Nystatin. Clin Ther. 2018 04; 40(4):660-662. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Phung N, Kuncze K, Okochi H, Louie A, Benet LZ, Ofokotun I, Haas DW, Currier JS, Chawana TD, Sheth AN, Bacchetti P, Gandhi M, Horng H. Development and validation of an assay to analyze atazanavir in human hair via liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2018 Mar 15; 32(5):431-441. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Parasrampuria DA, Benet LZ, Sharma A. Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations. AAPS J. 2018 03 13; 20(3):46. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Park J, Thomas S, Zhong AY, Wolfe AR, Krings G, Terranova-Barberio M, Pawlowska N, Benet LZ, Munster PN. Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer. Sci Rep. 2018 01 08; 8(1):92. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Koss CA, Hosek SG, Bacchetti P, Anderson PL, Liu AY, Horng H, Benet LZ, Kuncze K, Louie A, Saberi P, Wilson CM, Gandhi M. Comparison of Measures of Adherence to Human Immunodeficiency Virus Preexposure Prophylaxis Among Adolescent and Young Men Who Have Sex With Men in the United States. Clin Infect Dis. 2018 01 06; 66(2):213-219. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Liu S, Wolfe AR. The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio. Clin Pharmacol Ther. 2018 03; 103(3):521-525. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Morrissey KM, Benet LZ, Ware JA. Commentary on: "Influence of OATP1B1 Function on the Disposition of Sorafenib-β-D-Glucuronide". Clin Transl Sci. 2017 07; 10(4):240-241. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Wu HF. Understanding the Potential Interethnic Difference in Rosuvastatin Pharmacokinetics. J Pharm Sci. 2017 09; 106(9):2231-2233. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Noguchi S, Nishimura T, Mukaida S, Benet LZ, Nakashima E, Tomi M. Cellular Uptake of Levocetirizine by Organic Anion Transporter 4. J Pharm Sci. 2017 09; 106(9):2895-2898. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ. Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions. J Pharm Sci. 2017 09; 106(9):2751-2757. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Chan R, Benet LZ. Evaluation of DILI Predictive Hypotheses in Early Drug Development. Chem Res Toxicol. 2017 04 17; 30(4):1017-1029. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Koss CA, Bacchetti P, Hillier SL, Livant E, Horng H, Mgodi N, Mirembe BG, Gomez Feliciano K, Horn S, Liu AY, Glidden DV, Grant RM, Benet LZ, Louie A, van der Straten A, Chirenje ZM, Marrazzo JM, Gandhi M. Differences in Cumulative Exposure and Adherence to Tenofovir in the VOICE, iPrEx OLE, and PrEP Demo Studies as Determined via Hair Concentrations. AIDS Res Hum Retroviruses. 2017 08; 33(8):778-783. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ. Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption. Pharm Res. 2017 03; 34(3):619-628. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Li J, Larregieu CA, Benet LZ. Classification of natural products as sources of drugs according to the biopharmaceutics drug disposition classification system (BDDCS). Chin J Nat Med. 2016 Dec; 14(12):888-897. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Burmeister Getz E, Carroll KJ, Mielke J, Benet LZ, Jones B. Between-Batch Pharmacokinetic Variability Inflates Type I Error Rate in Conventional Bioequivalence Trials: A Randomized Advair Diskus Clinical Trial. Clin Pharmacol Ther. 2017 03; 101(3):331-340. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gandhi M, Glidden DV, Mayer K, Schechter M, Buchbinder S, Grinsztejn B, Hosek S, Casapia M, Guanira J, Bekker LG, Louie A, Horng H, Benet LZ, Liu A, Grant RM. Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. Lancet HIV. 2016 11; 3(11):e521-e528. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Bowman CM, Benet LZ. Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System. Drug Metab Dispos. 2016 11; 44(11):1731-1735. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. 2016 Remington Honor Medal Address: Science for the profession. J Am Pharm Assoc (2003). 2016 Jul-Aug; 56(4):365-8. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, Dooley KE, Gupta A, Gandhi M. Isoniazid hair concentrations in children with tuberculosis: a proof of concept study. Int J Tuberc Lung Dis. 2016 06; 20(6):844-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Hosey CM, Ursu O, Oprea TI. BDDCS, the Rule of 5 and drugability. Adv Drug Deliv Rev. 2016 06 01; 101:89-98. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Burmeister Getz E, Carroll KJ, Jones B, Benet LZ. Batch-to-batch pharmacokinetic variability confounds current bioequivalence regulations: A dry powder inhaler randomized clinical trial. Clin Pharmacol Ther. 2016 Sep; 100(3):223-31. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Chan R, Wei CY, Chen YT, Benet LZ. Use of the Biopharmaceutics Drug Disposition Classification System (BDDCS) to Help Predict the Occurrence of Idiosyncratic Cutaneous Adverse Drug Reactions Associated with Antiepileptic Drug Usage. AAPS J. 2016 05; 18(3):757-66. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Zheng Y, Chen X, Benet LZ. Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain. Clin Pharmacokinet. 2016 Feb; 55(2):143-67. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Hosey CM, Chan R, Benet LZ. BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional Drugs. AAPS J. 2016 Jan; 18(1):251-60. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Garrison KL, Sahin S, Benet LZ. Few Drugs Display Flip-Flop Pharmacokinetics and These Are Primarily Associated with Classes 3 and 4 of the BDDCS. J Pharm Sci. 2015 Sep; 104(9):3229-35. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Hosey CM, Benet LZ. Predicting the extent of metabolism using in vitro permeability rate measurements and in silico permeability rate predictions. Mol Pharm. 2015 May 04; 12(5):1456-66. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Zheng Y, Benet LZ, Okochi H, Chen X. pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion. Pharm Res. 2015 Aug; 32(8):2516-26. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler KM, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG. A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15(6):377-83. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Parasrampuria DA, Benet LZ. Inclusion of placebos and blinding for ascending dose first-in-human studies and other underpowered phase 1 studies has not been justified and on balance is not useful. Basic Clin Pharmacol Toxicol. 2015 Jul; 117(1):44-51. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 Nov; 16(6):1358-65. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Hosey CM, Broccatelli F, Benet LZ. Predicting when biliary excretion of parent drug is a major route of elimination in humans. AAPS J. 2014 Sep; 16(5):1085-96. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Larregieu CA, Benet LZ. Distinguishing between the permeability relationships with absorption and metabolism to improve BCS and BDDCS predictions in early drug discovery. Mol Pharm. 2014 Apr 07; 11(4):1335-44. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ. Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. Transplantation. 2014 Mar 27; 97(6):702-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S. Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature. 2014 Apr 03; 508(7494):93-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA. Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development. Mol Pharm. 2013 Nov 04; 10(11):4055-62. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Estudante M, Maya M, Morais JG, Soveral G, Benet LZ. Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil. Mol Pharm. 2013 Nov 04; 10(11):4038-45. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov; 34(8):442-51. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 04; 10(11):4032-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Horng H, Benet LZ. The nonenzymatic reactivity of the acyl-linked metabolites of mefenamic acid toward amino and thiol functional group bionucleophiles. Drug Metab Dispos. 2013 Nov; 41(11):1923-33. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Horng H, Benet LZ. Characterization of the acyl-adenylate linked metabolite of mefenamic Acid. Chem Res Toxicol. 2013 Mar 18; 26(3):465-76. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharm Res. 2013 Apr; 30(4):932-50. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Larregieu CA, Benet LZ. Drug discovery and regulatory considerations for improving in silico and in vitro predictions that use Caco-2 as a surrogate for human intestinal permeability measurements. AAPS J. 2013 Apr; 15(2):483-97. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development. J Pharm Sci. 2013 Jan; 102(1):34-42. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. A step closer to personalized chemotherapy: consideration of the influence of genetic variation in hepatic uptake transporters on the metabolism of CYP3A substrates. Clin Pharmacol Ther. 2012 Nov; 92(5):551-2. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Estudante M, Morais JG, Soveral G, Benet LZ. Intestinal drug transporters: an overview. Adv Drug Deliv Rev. 2013 Oct; 65(10):1340-56. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA. Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy? Clin Pharmacol Ther. 2012 Aug; 92(2):203-13. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Benet L Z and Galeazzi R L: noncompartmental determination of the steady-state volume of distribution, J Pharm Sci 68, 1071-1074, 1979--the backstory. AAPS J. 2012 Jun; 14(2):164-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Liu W, Okochi H, Benet LZ, Zhai SD. Sotalol permeability in cultured-cell, rat intestine, and PAMPA system. Pharm Res. 2012 Jul; 29(7):1768-74. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Broccatelli F, Cruciani G, Benet LZ, Oprea TI. BDDCS class prediction for new molecular entities. Mol Pharm. 2012 Mar 05; 9(3):570-80. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Broccatelli F, Larregieu CA, Cruciani G, Oprea TI, Benet LZ. Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan; 64(1):95-109. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Frymoyer A, Guglielmo BJ, Wilson SD, Scarpace SB, Benet LZ, Hersh AL. Impact of a hospitalwide increase in empiric pediatric vancomycin dosing on initial trough concentrations. Pharmacotherapy. 2011 Sep; 31(9):871-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Grover A, Frassetto LA, Benet LZ, Chakkera HA. Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients. Drug Metab Dispos. 2011 Nov; 39(11):2017-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Broccatelli F, Oprea TI. BDDCS applied to over 900 drugs. AAPS J. 2011 Dec; 13(4):519-47. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Rowland M, Benet LZ. Lead PK commentary: predicting human pharmacokinetics. J Pharm Sci. 2011 Oct; 100(10):4047-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Terasaki T, Sugiyama Y, Benet LZ. Professor Akira Tsuji: scientist, educator, and leader. J Pharm Sci. 2011 Sep; 100(9):3541-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Reyes M, Benet LZ. Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics. J Pharm Sci. 2011 Sep; 100(9):3831-42. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Grover A, Benet LZ. Intermittent drug dosing intervals guided by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation. J Pharmacokinet Pharmacodyn. 2011 Jun; 38(3):369-83. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX. The BCS, BDDCS, and regulatory guidances. Pharm Res. 2011 Jul; 28(7):1774-8. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Park MS, Okochi H, Benet LZ. Is Ciprofloxacin a Substrate of P-glycoprotein? Arch Drug Inf. 2011 Mar; 4(1):1-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Aarons L, Benet LZ. Founding figures of pharmacokinetics: tribute to Malcolm Rowland. J Pharmacokinet Pharmacodyn. 2010 Dec; 37(6):525-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Clearance (née Rowland) concepts: a downdate and an update. J Pharmacokinet Pharmacodyn. 2010 Dec; 37(6):529-39. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology. 2011 Jan; 32(1):50-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ. Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers. Clin Pharmacol Ther. 2010 Oct; 88(4):540-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Larregieu CA. The FDA should eliminate the ambiguities in the current BCS biowaiver guidance and make public the drugs for which BCS biowaivers have been granted. Clin Pharmacol Ther. 2010 Sep; 88(3):405-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L. Membrane transporters in drug development. Nat Rev Drug Discov. 2010 Mar; 9(3):215-36. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Frymoyer A, Hersh AL, Coralic Z, Benet LZ, Joseph Guglielmo B. Prediction of vancomycin pharmacodynamics in children with invasive methicillin-resistant Staphylococcus aureus infections: a Monte Carlo simulation. Clin Ther. 2010 Mar; 32(3):534-42. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Sun H, Frassetto LA, Huang Y, Benet LZ. Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease. Clin Pharmacol Ther. 2010 Apr; 87(4):465-72. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Grillo MP, Wait JC, Tadano Lohr M, Khera S, Benet LZ. Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes. Drug Metab Dispos. 2010 Jan; 38(1):133-42. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Predicting drug disposition via application of a Biopharmaceutics Drug Disposition Classification System. Basic Clin Pharmacol Toxicol. 2010 Mar; 106(3):162-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> de Souza J, Benet LZ, Huang Y, Storpirtis S. Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers. J Pharm Sci. 2009 Nov; 98(11):4413-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. The drug transporter-metabolism alliance: uncovering and defining the interplay. Mol Pharm. 2009 Nov-Dec; 6(6):1631-43. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. A Holy Grail of clinical pharmacology: prediction of drug pharmacokinetics and pharmacodynamics in the individual patient. Clin Pharmacol Ther. 2009 Aug; 86(2):133-4. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Shugarts S, Benet LZ. The role of transporters in the pharmacokinetics of orally administered drugs. Pharm Res. 2009 Sep; 26(9):2039-54. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Frymoyer A, Hersh AL, Benet LZ, Guglielmo BJ. Current recommended dosing of vancomycin for children with invasive methicillin-resistant Staphylococcus aureus infections is inadequate. Pediatr Infect Dis J. 2009 May; 28(5):398-402. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Grover A, Benet LZ. Effects of drug transporters on volume of distribution. AAPS J. 2009 Jun; 11(2):250-61. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gandhi M, Benet LZ, Bacchetti P, Kalinowski A, Anastos K, Wolfe AR, Young M, Cohen M, Minkoff H, Gange SJ, Greenblatt RM, Women's Interagency HIV Study. Nonnucleoside reverse transcriptase inhibitor pharmacokinetics in a large unselected cohort of HIV-infected women. J Acquir Immune Defic Syndr. 2009 Apr 15; 50(5):482-91. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Sahin S, Benet LZ. The operational multiple dosing half-life: a key to defining drug accumulation in patients and to designing extended release dosage forms. Pharm Res. 2008 Dec; 25(12):2869-77. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Zheng HX, Huang Y, Frassetto LA, Benet LZ. Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite. Clin Pharmacol Ther. 2009 Jan; 85(1):78-85. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. J Infect Dev Ctries. 2008 Oct 01; 2(5):379-83. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Grillo MP, Hua F, March KL, Benet LZ, Knutson CG, Ware JA. Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat. Chem Res Toxicol. 2008 Oct; 21(10):1933-8. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Amidon GL, Barends DM, Lennernäs H, Polli JE, Shah VP, Stavchansky SA, Yu LX. The use of BDDCS in classifying the permeability of marketed drugs. Pharm Res. 2008 Mar; 25(3):483-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Li C, Grillo MP, Badagnani I, Fife KL, Benet LZ. Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats. Drug Metab Dispos. 2008 Apr; 36(4):682-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune JM, Bredt BM, Stablein DM, Stock PG. HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes. Am J Transplant. 2008 Feb; 8(2):355-65. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Custodio JM, Wu CY, Benet LZ. Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Adv Drug Deliv Rev. 2008 Mar 17; 60(6):717-33. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ. Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. Am J Transplant. 2007 Dec; 7(12):2816-20. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Boernsen KO, Egge-Jacobsen W, Inverardi B, Strom T, Streit F, Schiebel HM, Benet LZ, Christians U. Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus. J Mass Spectrom. 2007 Jun; 42(6):793-802. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ. Effects of uptake and efflux transporter inhibition on erythromycin breath test results. Clin Pharmacol Ther. 2007 Jun; 81(6):828-32. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Olsen J, Li C, Skonberg C, Bjørnsdottir I, Sidenius U, Benet LZ, Hansen SH. Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats. Drug Metab Dispos. 2007 May; 35(5):758-64. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Lau YY, Huang Y, Frassetto L, Benet LZ. effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Clin Pharmacol Ther. 2007 Feb; 81(2):194-204. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lam JL, Shugarts SB, Okochi H, Benet LZ. Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism. J Pharmacol Exp Ther. 2006 Nov; 319(2):864-70. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Lam JL, Okochi H, Huang Y, Benet LZ. In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay. Drug Metab Dispos. 2006 Aug; 34(8):1336-44. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lau YY, Okochi H, Huang Y, Benet LZ. Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism. Drug Metab Dispos. 2006 Jul; 34(7):1175-81. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006 Jul; 34(7):1136-44. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET. Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma. Rapid Commun Mass Spectrom. 2006; 20(10):1611-4. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH. A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Antimicrob Agents Chemother. 2005 Dec; 49(12):5160-1. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Olsen J, Li C, Bjørnsdottir I, Sidenius U, Hansen SH, Benet LZ. In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats. Chem Res Toxicol. 2005 Nov; 18(11):1729-36. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Lau YY, Okochi H, Huang Y, Benet LZ. Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems. J Pharmacol Exp Ther. 2006 Feb; 316(2):762-71. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Chang JH, Benet LZ. Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells. Mol Pharm. 2005 Sep-Oct; 2(5):428-34. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Sun H, Frassetto L, Benet LZ. Effects of renal failure on drug transport and metabolism. Pharmacol Ther. 2006 Jan; 109(1-2):1-11. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L. Effects of short-term alendronate on bone mineral density in haemodialysis patients. Nephrology (Carlton). 2005 Aug; 10(4):393-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Transplantation. 2005 Jul 15; 80(1):13-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Putnam WS, Woo JM, Huang Y, Benet LZ. Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics. J Clin Pharmacol. 2005 Apr; 45(4):411-21. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found. Mol Interv. 2005 Apr; 5(2):79-83. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet L. Basic pharmacological interactions and how they may impact on one another. J Acquir Immune Defic Syndr. 2005 Mar; 38 Suppl 1:S22-3. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Wu CY, Benet LZ. Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res. 2005 Jan; 22(1):11-23. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Mohri K, Okada K, Benet LZ. Stereoselective taurine conjugation of (R)-benoxaprofen enantiomer in rats: in vivo and in vitro studies using rat hepatic mitochondria and microsomes. Pharm Res. 2005 Jan; 22(1):79-85. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Lam JL, Benet LZ. Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes. Drug Metab Dispos. 2004 Nov; 32(11):1311-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U. Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Ther Drug Monit. 2004 Oct; 26(5):546-62. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Ikeno F, Lyons J, Kaneda H, Baluom M, Benet LZ, Rezaee M. Novel percutaneous adventitial drug delivery system for regional vascular treatment. Catheter Cardiovasc Interv. 2004 Oct; 63(2):222-30. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. Br J Pharmacol. 2004 Oct; 143(3):388-96. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Sun H, Huang Y, Frassetto L, Benet LZ. Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Drug Metab Dispos. 2004 Nov; 32(11):1239-46. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Kim WY, Benet LZ. P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul; 21(7):1284-93. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Cummins CL, Wu CY. Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. Int J Pharm. 2004 Jun 11; 277(1-2):3-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Frassetto LA, Benet LZ. Pharmacogenomics and transplantation: where are we? Am J Transplant. 2004 Jun; 4(6):843. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Serkova NJ, Christians U, Benet LZ. Biochemical mechanisms of cyclosporine neurotoxicity. Mol Interv. 2004 Apr; 4(2):97-107. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lau YY, Wu CY, Okochi H, Benet LZ. Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay. J Pharmacol Exp Ther. 2004 Mar; 308(3):1040-5. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Wu CY, Benet LZ. Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918. Drug Metab Dispos. 2003 Nov; 31(11):1292-5. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Cummins CL, Jacobsen W, Christians U, Benet LZ. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. J Pharmacol Exp Ther. 2004 Jan; 308(1):143-55. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Cummins CL, Wu CY. Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. Curr Drug Metab. 2003 Oct; 4(5):393-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Li C, Olurinde MO, Hodges LM, Grillo MP, Benet LZ. Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro. Drug Metab Dispos. 2003 Jun; 31(6):727-30. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Li C, Grillo MP, Benet LZ. In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat. J Pharmacol Exp Ther. 2003 Apr; 305(1):250-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Cummins CL, Salphati L, Reid MJ, Benet LZ. In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model. J Pharmacol Exp Ther. 2003 Apr; 305(1):306-14. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Li C, Grillo MP, Benet LZ. In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester. Toxicol Appl Pharmacol. 2003 Mar 01; 187(2):101-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC. Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Drug Metab Pharmacokinet. 2003; 18(2):114-20. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Hebert MF, Wacher VJ, Roberts JP, Benet LZ. Pharmacokinetics of cyclosporine pre- and post-liver transplantation. J Clin Pharmacol. 2003 Jan; 43(1):38-42. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Putnam WS, Ramanathan S, Pan L, Takahashi LH, Benet LZ. Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells. J Pharm Sci. 2002 Dec; 91(12):2622-35. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ. Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). Planta Med. 2002 Dec; 68(12):1055-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Li C, Benet LZ, Grillo MP. Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes. Chem Res Toxicol. 2002 Nov; 15(11):1480-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Cummins CL, Wu CY, Benet LZ. Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein. Clin Pharmacol Ther. 2002 Nov; 72(5):474-89. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Li C, Benet LZ, Grillo MP. Studies on the chemical reactivity of 2-phenylpropionic acid 1-O-acyl glucuronide and S-acyl-CoA thioester metabolites. Chem Res Toxicol. 2002 Oct; 15(10):1309-17. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N. Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine. J Pharmacol Exp Ther. 2002 Sep; 302(3):1123-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Susanto M, Benet LZ. Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport? Pharm Res. 2002 Apr; 19(4):457-62. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Flanagan SD, Takahashi LH, Liu X, Benet LZ. Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells. J Pharm Sci. 2002 Apr; 91(4):1169-77. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Hoener BA. Changes in plasma protein binding have little clinical relevance. Clin Pharmacol Ther. 2002 Mar; 71(3):115-21. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. J Cereb Blood Flow Metab. 2002 Mar; 22(3):342-52. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Parasrampuria DA, Lantz MV, Birnbaum JL, Vincenti FG, Benet LZ. Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation. J Clin Pharmacol. 2002 Mar; 42(3):304-11. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Cummins CL, Jacobsen W, Benet LZ. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. J Pharmacol Exp Ther. 2002 Mar; 300(3):1036-45. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Unger M, Jacobsen W, Holzgrabe U, Benet LZ. Quantitative liquid chromatography-mass spectrometry determination of isatin in urine using automated on-line extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Feb 15; 767(2):245-53. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Putnam WS, Pan L, Tsutsui K, Takahashi L, Benet LZ. Comparison of bidirectional cephalexin transport across MDCK and caco-2 cell monolayers: interactions with peptide transporters. Pharm Res. 2002 Jan; 19(1):27-33. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ. Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology. 2002; 64(3):126-34. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Christians U, Jacobsen W, Benet LZ, Lampen A. Mechanisms of clinically relevant drug interactions associated with tacrolimus. Clin Pharmacokinet. 2002; 41(11):813-51. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Grillo MP, Benet LZ. Studies on the reactivity of clofibryl-S-acyl-CoA thioester with glutathione in vitro. Drug Metab Dispos. 2002 Jan; 30(1):55-62. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A. Red wine decreases cyclosporine bioavailability. Clin Pharmacol Ther. 2001 Nov; 70(5):462-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Cummins CL. The drug efflux-metabolism alliance: biochemical aspects. Adv Drug Deliv Rev. 2001 Oct 01; 50 Suppl 1:S3-11. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Grillo MP, Chiellini G, Tonelli M, Benet LZ. Effect of alpha-fluorination of valproic acid on valproyl-S-acyl-CoA formation in vivo in rats. Drug Metab Dispos. 2001 Sep; 29(9):1210-5. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Cummins CL, Mangravite LM, Benet LZ. Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Pharm Res. 2001 Aug; 18(8):1102-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Grillo MP, Benet LZ. Interaction of gamma-glutamyltranspeptidase with clofibryl-S-acyl-glutathione in vitro and in vivo in rat. Chem Res Toxicol. 2001 Aug; 14(8):1033-40. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U. Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain. Br J Pharmacol. 2001 Jul; 133(6):875-85. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Kuhn B, Jacobsen W, Christians U, Benet LZ, Kollman PA. Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations. J Med Chem. 2001 Jun 07; 44(12):2027-34. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Wacher VJ, Salphati L, Benet LZ. Active secretion and enterocytic drug metabolism barriers to drug absorption. Adv Drug Deliv Rev. 2001 Mar 01; 46(1-3):89-102. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Jacobsen W, Serkova N, Hausen B, Morris RE, Benet LZ, Christians U. Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD. Transplant Proc. 2001 Feb-Mar; 33(1-2):514-5. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Sawamoto T, Van Gelder T, Christians U, Okamura N, Jacobsen W, Benet L. Membrane transport of mycophenolate mofetil and its active metabolite, mycophenolic acid in MDCK and MDR1-MDCK cell monolayers. J Heart Lung Transplant. 2001 Feb; 20(2):234-235. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Parasrampuria DA, Lantz MV, Benet LZ. A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function. Pharm Res. 2001 Jan; 18(1):39-44. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Qiu Y, Benet LZ, Burlingame AL. Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry. Adv Exp Med Biol. 2001; 500:663-73. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Zhang Y, Benet LZ. The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein. Clin Pharmacokinet. 2001; 40(3):159-68. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U. The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups. Clin Pharmacol Ther. 2001 Jan; 69(1):24-31. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Boni JR, Korth-Bradley JM, Richards LS, Chiang ST, Hicks DR, Benet LZ. Chiral bioequivalence: effect of absorption rate on racemic etodolac. Clin Pharmacokinet. 2000 Dec; 39(6):459-69. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Jacobsen W, Christians U, Benet LZ. In vitro evaluation of the disposition of A novel cysteine protease inhibitor. Drug Metab Dispos. 2000 Nov; 28(11):1343-51. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U. Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin. Drug Metab Dispos. 2000 Nov; 28(11):1369-78. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Christians U, Jacobsen W, Serkova N, Benet LZ, Vidal C, Sewing KF, Manns MP, Kirchner GI. Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. J Chromatogr B Biomed Sci Appl. 2000 Oct 01; 748(1):41-53. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Serkova N, Hausen B, Berry GJ, Jacobsen W, Benet LZ, Morris RE, Christians U. Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine. J Pharmacol Exp Ther. 2000 Jul; 294(1):323-32. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Christians U, First MR, Benet LZ. Recommendations for bioequivalence testing of cyclosporine generics revisited. Ther Drug Monit. 2000 Jun; 22(3):330-45. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Soldner A, Benet LZ, Mutschler E, Christians U. Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. Br J Pharmacol. 2000 Mar; 129(6):1235-43. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Serkova N, Litt L, Leibfritz D, Hausen B, Morris RE, James TL, Benet LZ, Christians U. The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates. Br J Pharmacol. 2000 Feb; 129(3):485-92. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Hausen B, Ikonen T, Briffa N, Berry GJ, Christians U, Robbins RC, Hook L, Serkova N, Benet LZ, Schuler W, Morris RE. Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability. Transplantation. 2000 Jan 15; 69(1):76-86. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Jäger W, Correia MA, Bornheim LM, Mahnke A, Hanstein WG, Xue L, Benet LZ. Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism. Drug Metab Dispos. 1999 Dec; 27(12):1505-11. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Izumi T, Zhang Y, Silverman JA, Wacher VJ. Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery. J Control Release. 1999 Nov 01; 62(1-2):25-31. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Baner K, Benet LZ, Sewing KF, Christians U. Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin. J Pharmacol Exp Ther. 1999 Oct; 291(1):131-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Mizuma T, McDonagh AF, Lin ET, Benet LZ. Photoinduced covalent binding of frusemide and frusemide glucuronide to human serum albumin. Br J Clin Pharmacol. 1999 Jul; 48(1):79-87. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Serkova N, Litt L, James TL, Sadée W, Leibfritz D, Benet LZ, Christians U. Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy. J Pharmacol Exp Ther. 1999 May; 289(2):800-6. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Relevance of pharmacokinetics in narrow therapeutic index drugs. Transplant Proc. 1999 May; 31(3):1642-4; discussion 1675-84. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Understanding bioequivalence testing. Transplant Proc. 1999 May; 31(3A Suppl):7S-9S. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Hausen B, Boeke K, Berry GJ, Segarra I, Benet LZ, Christians U, Morris RE. Coadministration of neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: potentiation of immunosuppressive efficacy and improvement of tolerability of staggered versus simultaneous treatment. Transplantation. 1999 Apr 15; 67(7):956-62. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res. 1999 Apr; 16(4):478-85. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Mizuma T, Benet LZ, Lin ET. Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible binding and irreversible binding of a 1-O-acyl glucuronide metabolite. Biopharm Drug Dispos. 1999 Apr; 20(3):131-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Zhang Y, Guo X, Lin ET, Benet LZ. In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes. Pharmacology. 1999 Mar; 58(3):147-59. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U. Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos. 1999 Feb; 27(2):173-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Salphati L, Benet LZ. Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A. Xenobiotica. 1999 Feb; 29(2):171-85. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Hall SD, Thummel KE, Watkins PB, Lown KS, Benet LZ, Paine MF, Mayo RR, Turgeon DK, Bailey DG, Fontana RJ, Wrighton SA. Molecular and physical mechanisms of first-pass extraction. Drug Metab Dispos. 1999 Feb; 27(2):161-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Flanagan SD, Benet LZ. Net secretion of furosemide is subject to indomethacin inhibition, as observed in Caco-2 monolayers and excised rat jejunum. Pharm Res. 1999 Feb; 16(2):221-24. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Segarra I, Brazelton TR, Guterman N, Hausen B, Jacobsen W, Morris RE, Benet LZ, Christians U. Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin. J Chromatogr B Biomed Sci Appl. 1998 Dec 11; 720(1-2):179-87. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Tsunoda SM, Harris RZ, Mroczkowski PJ, Benet LZ. Preliminary evaluation of progestins as inducers of cytochrome P450 3A4 activity in postmenopausal women. J Clin Pharmacol. 1998 Dec; 38(12):1137-43. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Wacher VJ, Silverman JA, Zhang Y, Benet LZ. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J Pharm Sci. 1998 Nov; 87(11):1322-30. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Mizuma T, Benet LZ, Lin ET. High-performance liquid chromatographic determination and identification of acyl migration and photodegradation products of furosemide 1-O-acyl glucuronide. J Chromatogr B Biomed Sci Appl. 1998 Oct 23; 718(1):153-62. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Zhang Y, Benet LZ. Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers. Pharm Res. 1998 Oct; 15(10):1520-4. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Zhang Y, Hsieh Y, Izumi T, Lin ET, Benet LZ. Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats. J Pharmacol Exp Ther. 1998 Oct; 287(1):246-52. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Impact of intraindividual variability of drugs on therapeutic outcomes: lessons from outside transplantation. Transplant Proc. 1998 Aug; 30(5):1650-1. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Qiu Y, Benet LZ, Burlingame AL. Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry. J Biol Chem. 1998 Jul 10; 273(28):17940-53. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Salphati L, Benet LZ. Effects of ketoconazole on digoxin absorption and disposition in rat. Pharmacology. 1998 Jun; 56(6):308-13. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lampen A, Zhang Y, Hackbarth I, Benet LZ, Sewing KF, Christians U. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. J Pharmacol Exp Ther. 1998 Jun; 285(3):1104-12. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Zhang Y, Guo X, Lin ET, Benet LZ. Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor. Drug Metab Dispos. 1998 Apr; 26(4):360-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Mohri K, Okada K, Benet LZ. Stereoselective metabolism of benoxaprofen in rats. Biliary excretion of benoxaprofen taurine conjugate and glucuronide. Drug Metab Dispos. 1998 Apr; 26(4):332-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Jang GR, Benet LZ. Antiprogestin-mediated inactivation of cytochrome P450 3A4. Pharmacology. 1998 Mar; 56(3):150-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Qiu Y, Burlingame AL, Benet LZ. Mechanisms for covalent binding of benoxaprofen glucuronide to human serum albumin. Studies By tandem mass spectrometry. Drug Metab Dispos. 1998 Mar; 26(3):246-56. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Salphati L, Benet LZ. Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers. Biochem Pharmacol. 1998 Feb 15; 55(4):387-95. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Mizuma T, Benet LZ, Lin ET. Preparative chromatography of furosemide 1-O-acyl-glucuronide from urine using micronized amberiite XAD-2 and its application to other 1-O-acyl-glucuronides. Prep Biochem Biotechnol. 1998 Feb; 28(1):37-47. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Jang GR, Benet LZ. Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use. J Pharmacokinet Biopharm. 1997 Dec; 25(6):647-72. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Jang GR, Benet LZ. Cytochrome P4503A4-mediated N-demethylation of the antiprogestins lilopristone and onapristone. Drug Metab Dispos. 1997 Oct; 25(10):1119-22. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown MB, Guo W, Rossi SJ, Benet LZ, Watkins PB. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol Ther. 1997 Sep; 62(3):248-60. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Floren LC, Bekersky I, Benet LZ, Mekki Q, Dressler D, Lee JW, Roberts JP, Hebert MF. Tacrolimus oral bioavailability doubles with coadministration of ketoconazole. Clin Pharmacol Ther. 1997 Jul; 62(1):41-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Yuan R, Sumi M, Benet LZ. Investigation of aortic CYP3A bioactivation of nitroglycerin in vivo. J Pharmacol Exp Ther. 1997 Jun; 281(3):1499-505. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Wu ST, Benet LZ, Lin ET. Determination of amiprilose in human plasma by high-performance liquid chromatography with fluorimetric detection. J Chromatogr B Biomed Sci Appl. 1997 Apr 25; 692(1):149-56. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Wu ST, Chang YP, Gee WL, Benet LZ, Lin ET. Stereoselective high-performance liquid chromatography determination of propranolol and 4-hydroxypropranolol in human plasma after pre-column derivatization. J Chromatogr B Biomed Sci Appl. 1997 Apr 25; 692(1):133-40. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Shah VP, Yacobi A, Barr WH, Benet LZ, Breimer D, Dobrinska MR, Endrenyi L, Fairweather W, Gillespie W, Gonzalez MA, Hooper J, Jackson A, Lesko LJ, Midha KK, Noonan PK, Patnaik R, Williams RL. Evaluation of orally administered highly variable drugs and drug formulations. Pharm Res. 1996 Nov; 13(11):1590-4. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Sambol NC, Chiang J, O'Conner M, Liu CY, Lin ET, Goodman AM, Benet LZ, Karam JH. Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus. J Clin Pharmacol. 1996 Nov; 36(11):1012-21. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Sambol NC, Brookes LG, Chiang J, Goodman AM, Lin ET, Liu CY, Benet LZ. Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man. Br J Clin Pharmacol. 1996 Oct; 42(4):510-2. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Morality play. Science. 1996 Sep 27; 273(5283):1782; author reply 1784-5. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Jang GR, Wrighton SA, Benet LZ. Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes. Biochem Pharmacol. 1996 Sep 13; 52(5):753-61. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Haj-Yehia AI, Benet LZ. In vivo depletion of free thiols does not account for nitroglycerin-induced tolerance: a thiol-nitrate interaction hypothesis as an alternative explanation for nitroglycerin activity and tolerance. J Pharmacol Exp Ther. 1996 Sep; 278(3):1296-305. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Iwaki M, Ogiso T, Hayashi H, Tanino T, Benet LZ. Acute dose-dependent disposition studies of nicotinic acid in rats. Drug Metab Dispos. 1996 Jul; 24(7):773-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Kenkare SR, Benet LZ. Tolerance to nitroglycerin in rabbit aorta. Investigating the involvement of the mu isozyme of glutathione S-transferases. Biochem Pharmacol. 1996 May 17; 51(10):1357-63. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Berg-Candolfi M, Candolfi E, Benet LZ. Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression. Xenobiotica. 1996 Apr; 26(4):381-94. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Harris RZ, Tsunoda SM, Mroczkowski P, Wong H, Benet LZ. The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics. Clin Pharmacol Ther. 1996 Apr; 59(4):429-35. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Jaeger W, Benet LZ, Bornheim LM. Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes. Xenobiotica. 1996 Mar; 26(3):275-84. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther. 1996 Mar; 59(3):297-303. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Wu CY, Benet LZ, Hebert MF, Gupta SK, Rowland M, Gomez DY, Wacher VJ. Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Clin Pharmacol Ther. 1995 Nov; 58(5):492-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Sambol NC, Chiang J, Lin ET, Goodman AM, Liu CY, Benet LZ, Cogan MG. Kidney function and age are both predictors of pharmacokinetics of metformin. J Clin Pharmacol. 1995 Nov; 35(11):1094-102. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Zia-Amirhosseini P, Ding A, Burlingame AL, McDonagh AF, Benet LZ. Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac. Biochem J. 1995 Oct 15; 311 ( Pt 2):431-5. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> d'Uscio CH, Aweeka FT, Prueksaritanont T, Tomlanovich SJ, Gupta SK, Lantz MV, Gambertoglio JG, Garovoy MR, Benet LZ. Immunopharmacodynamic studies of cyclosporine in patients awaiting renal transplantation. J Clin Pharmacol. 1995 Oct; 35(10):967-73. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Iwaki M, Bischer A, Nguyen AC, McDonagh AF, Benet LZ. Stereoselective disposition of naproxen glucuronide in the rat. Drug Metab Dispos. 1995 Oct; 23(10):1099-103. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Bischer A, Iwaki M, Zia-Amirhosseini P, Benet LZ. Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin. Drug Metab Dispos. 1995 Sep; 23(9):900-3. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Bornheim LM, Kim KY, Li J, Perotti BY, Benet LZ. Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain. Drug Metab Dispos. 1995 Aug; 23(8):825-31. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Harris RZ, Benet LZ, Schwartz JB. Gender effects in pharmacokinetics and pharmacodynamics. Drugs. 1995 Aug; 50(2):222-39. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Bischer A, Zia-Amirhosseini P, Iwaki M, McDonagh AF, Benet LZ. Stereoselective binding properties of naproxen glucuronide diastereomers to proteins. J Pharmacokinet Biopharm. 1995 Aug; 23(4):379-95. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Goyan JE. Bioequivalence and narrow therapeutic index drugs. Pharmacotherapy. 1995 Jul-Aug; 15(4):433-40. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog. 1995 Jul; 13(3):129-34. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Gomez DY, Wacher VJ, Tomlanovich SJ, Hebert MF, Benet LZ. The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clin Pharmacol Ther. 1995 Jul; 58(1):15-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Wacher VJ, Liu T, Roberts JP, Ascher NL, Benet LZ. Time course of cyclosporine and ist motabolites in blood, liver and spleen of naive Lewis rats: comparison with preliminary data obtained in transplanted animals. Biopharm Drug Dispos. 1995 May; 16(4):303-12. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Haj-Yehia AI, Benet LZ. 2-(4-N-maleimidophenyl)-6-methoxybenzofuran: a superior derivatizing agent for fluorimetric determination of aliphatic thiols by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 Apr 07; 666(1):45-53. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Haj-Yehia AI, Benet LZ. Dissociation of tissue thiols content from nitroglycerin-induced cyclic-3',5'-guanosine monophosphate and the state of tolerance: in vivo experiments in rats. J Pharmacol Exp Ther. 1995 Apr; 273(1):94-100. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Zia-Amirhosseini P. Basic principles of pharmacokinetics. Toxicol Pathol. 1995 Mar-Apr; 23(2):115-23. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Sekikawa H, Yagi N, Oda K, Kenmotsu H, Takada M, Chen HF, Lin ET, Benet LZ. Biliary excretion of furosemide glucuronide in rabbits. Biol Pharm Bull. 1995 Mar; 18(3):447-53. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Ding A, Zia-Amirhosseini P, McDonagh AF, Burlingame AL, Benet LZ. Reactivity of tolmetin glucuronide with human serum albumin. Identification of binding sites and mechanisms of reaction by tandem mass spectrometry. Drug Metab Dispos. 1995 Mar; 23(3):369-76. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Sekikawa H, Yagi N, Lin ET, Benet LZ. Apparent intramolecular acyl migration and hydrolysis of furosemide glucuronide in aqueous solution. Biol Pharm Bull. 1995 Jan; 18(1):134-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Haj-Yehia AI, Benet LZ. Determination of aliphatic thiols by fluorometric high-performance liquid chromatography after precolumn derivatization with 2-(4-N-maleimidophenyl)-6-methylbenzothiazole. Pharm Res. 1995 Jan; 12(1):155-60. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Zia-Amirhosseini PZ, Harris RZ, Brodsky FM, Benet LZ. Hypersensitivity to nonsteroidal anti-inflammatory drugs. Nat Med. 1995 Jan; 1(1):2-4. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Kenkare SR, Han C, Benet LZ. Correlation of the response to nitroglycerin in rabbit aorta with the activity of the mu class glutathione S-transferase. Biochem Pharmacol. 1994 Dec 16; 48(12):2231-5. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Iwaki M, Ogiso T, Hayashi H, Lin ET, Benet LZ. Simultaneous measurement of nicotinic acid and its major metabolite, nicotinuric acid in urine using high-performance liquid chromatography: application of solid-liquid extraction. J Chromatogr B Biomed Appl. 1994 Nov 04; 661(1):154-8. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Perotti BY, Prueksaritanont T, Benet LZ. HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes. Pharm Res. 1994 Jun; 11(6):844-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Ojingwa JC, Spahn-Langguth H, Benet LZ. Irreversible binding of tolmetin to macromolecules via its glucuronide: binding to blood constituents, tissue homogenates and subcellular fractions in vitro. Xenobiotica. 1994 Jun; 24(6):495-506. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Gustavson LE, Benet LZ. Menopause: pharmacodynamics and pharmacokinetics. Exp Gerontol. 1994 May-Aug; 29(3-4):437-44. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Han C, Jung P, Sanders SW, Lin ET, Benet LZ. Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration. Biopharm Drug Dispos. 1994 Mar; 15(2):179-83. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. J Clin Pharmacol. 1994 Feb; 34(2):111-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Ojingwa JC, Spahn-Langguth H, Benet LZ. Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma. J Pharmacokinet Biopharm. 1994 Feb; 22(1):19-40. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Zia-Amirhosseini P, Spahn-Langguth H, Benet LZ. Bioactivation by glucuronide-conjugate formation. Adv Pharmacol. 1994; 27:385-97. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Zia-Amirhosseini P, Ojingwa JC, Spahn-Langguth H, McDonagh AF, Benet LZ. Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing. Clin Pharmacol Ther. 1994 Jan; 55(1):21-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Perotti BY, Okudaira N, Prueksaritanont T, Benet LZ. FK 506 metabolism in male and female rat liver microsomes. Drug Metab Dispos. 1994 Jan-Feb; 22(1):85-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Pharmacokinetic profile of etodolac in special populations. Eur J Rheumatol Inflamm. 1994; 14(1):15-8. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Aweeka FT, Tomlanovich SJ, Prueksaritanont T, Gupta SK, Benet LZ. Pharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients. J Clin Pharmacol. 1994 Jan; 34(1):60-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Zech K. Pharmacokinetics--a relevant factor for the choice of a drug? Aliment Pharmacol Ther. 1994; 8 Suppl 1:25-32. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Munafo A, Hyneck ML, Benet LZ. Pharmacokinetics and irreversible binding of tolmetin and its glucuronic acid esters in the elderly. Pharmacology. 1993 Nov; 47(5):309-17. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lee FW, Salmonson T, Benet LZ. Pharmacokinetics and pharmacodynamics of nitroglycerin and its dinitrate metabolites in conscious dogs: intravenous infusion studies. J Pharmacokinet Biopharm. 1993 Oct; 21(5):533-50. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Gumbleton M, Benet LZ. Simultaneous pharmacodynamic modeling of the non-steady-state effects of three oral doses of 1,3-glyceryl dinitrate upon blood pressure in healthy volunteers. J Pharmacokinet Biopharm. 1993 Oct; 21(5):515-32. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Kenkare SR, Benet LZ. Effect of ethacrynic acid, a glutathione-S-transferase inhibitor, on nitroglycerin-mediated cGMP elevation and vasorelaxation of rabbit aortic strips. Biochem Pharmacol. 1993 Jul 20; 46(2):279-84. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Prueksaritanont T, Correia MA, Rettie AE, Swinney DC, Thomas PE, Benet LZ. Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzyme(s) other than cytochromes P-450 3A. Drug Metab Dispos. 1993 Jul-Aug; 21(4):730-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gupta SK, Hwang SS, Benet LZ, Gumbleton M. Interpretation and utilization of effect and concentration data collected in an in vivo pharmacokinetic and in vitro pharmacodynamic study. Pharm Res. 1993 Jun; 10(6):889-94. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Ding A, Ojingwa JC, McDonagh AF, Burlingame AL, Benet LZ. Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry. Proc Natl Acad Sci U S A. 1993 May 01; 90(9):3797-801. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Spahn-Langguth H, Benet LZ. Microsomal acyl glucuronidation: enzyme-kinetic studies with labile glucuronides. Pharmacology. 1993 May; 46(5):268-73. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Lee FW, Hu J, Metzler CH, Benet LZ. Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: a preliminary report. J Pharmacokinet Biopharm. 1993 Apr; 21(2):163-73. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. New techniques in drug metabolism and clinical pharmacology/pharmacokinetics. Am Biotechnol Lab. 1993 Feb; 11(2):44-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Mayer S, Mutschler E, Benet LZ, Sphahn-Langguth H. In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers. Chirality. 1993; 5(3):120-5. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Pharmacokinetics of sustained-release etodolac. Rheumatol Int. 1993; 13(2 Suppl):S3-5. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Spahn-Langguth H, Iwakawa S, Volland C, Mizuma T, Mayer S, Mutschler E, Lin ET. Predictability of the covalent binding of acidic drugs in man. Life Sci. 1993; 53(8):PL141-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Haefeli WE, Gumbleton M, Benet LZ, Hoffman BB, Blaschke TF. Comparison of vasodilatory responses to nitroglycerin and its dinitrate metabolites in human veins. Clin Pharmacol Ther. 1992 Dec; 52(6):590-6. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Hebert MF, Roberts JP, Prueksaritanont T, Benet LZ. Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction. Clin Pharmacol Ther. 1992 Nov; 52(5):453-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lau DT, Chan EK, Benet LZ. Glutathione S-transferase-mediated metabolism of glyceryl trinitrate in subcellular fractions of bovine coronary arteries. Pharm Res. 1992 Nov; 9(11):1460-4. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Cahalan MK, Hashimoto Y, Aizawa K, Verotta D, Ionescu P, Balea M, Eger EI, Benet LZ, Ehrenfeld WK, Goldstone J. Elderly, conscious patients have an accentuated hypotensive response to nitroglycerin. Anesthesiology. 1992 Oct; 77(4):646-55. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Han C, Gumbleton M, Lau DT, Benet LZ. Improved gas chromatographic assay for the simultaneous determination of nitroglycerin and its mono- and dinitrate metabolites. J Chromatogr. 1992 Sep 02; 579(2):237-45. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Prueksaritanont T, Hoener BA, Benet LZ. Effects of low-density lipoprotein and ethinyl estradiol on cyclosporine metabolism in isolated rat liver perfusions. Drug Metab Dispos. 1992 Jul-Aug; 20(4):547-52. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. J Pharm Sci. 1992 Jun; 81(6):605-10. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Pharm Res. 1992 Jun; 9(6):826-33. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lau DT, Benet LZ. Effects of sulfobromophthalein and ethacrynic acid on glyceryl trinitrate relaxation. Biochem Pharmacol. 1992 May 28; 43(10):2247-54. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Prueksaritanont T, Koike M, Hoener BA, Benet LZ. Transport and metabolism of cyclosporine in isolated rat hepatocytes. The effects of lipids. Biochem Pharmacol. 1992 May 08; 43(9):1997-2006. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Clin Pharmacol Ther. 1992 Apr; 51(4):465-73. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH. Cutaneous metabolism of nitroglycerin in vitro. II. Effects of skin condition and penetration enhancement. Pharm Res. 1992 Mar; 9(3):303-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH. Cutaneous metabolism of nitroglycerin in vitro. I. Homogenized versus intact skin. Pharm Res. 1992 Feb; 9(2):187-90. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Spahn-Langguth H, Benet LZ. Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism? Drug Metab Rev. 1992; 24(1):5-47. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Hale VG, Benet LZ. The interconversion of prednisone and prednisolone in human and rabbit organs in vitro is a function of tissue integrity. Pharmacology. 1992; 44(5):273-82. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Volland C, Sun H, Dammeyer J, Benet LZ. Stereoselective degradation of the fenoprofen acyl glucuronide enantiomers and irreversible binding to plasma protein. Drug Metab Dispos. 1991 Nov-Dec; 19(6):1080-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Hale VG, Aizawa K, Sheiner LB, Benet LZ. Disposition of prednisone and prednisolone in the perfused rabbit liver: modeling hepatic metabolic processes. J Pharmacokinet Biopharm. 1991 Oct; 19(5):597-614. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Kikkoji T, Gumbleton M, Higo N, Guy RH, Benet LZ. Percutaneous penetration kinetics of nitroglycerin and its dinitrate metabolites across hairless mouse skin in vitro. Pharm Res. 1991 Oct; 8(10):1231-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Iwakawa S, Spahn H, Benet LZ, Lin ET. Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats. Drug Metab Dispos. 1991 Sep-Oct; 19(5):853-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Hammarlund-Udenaes M, Benet LZ. Prednisone and prednisolone interconversion in the rabbit utilizing unbound concentrations. Biopharm Drug Dispos. 1991 Aug-Sep; 12(6):467-77. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Nakashima E, Lau DT, Benet LZ. Variable glyceryl dinitrate formation following infusions of glyceryl trinitrate at different vascular sites in the rat. Pharm Res. 1991 Jul; 8(7):877-82. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Williams RL, Thakker KM, John V, Lin ET, Liang-Gee W, Benet LZ. Nitroglycerin absorption from transdermal systems: formulation effects and metabolite concentrations. Pharm Res. 1991 Jun; 8(6):744-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Iwakawa S, He XW, Hashimoto S, Volland C, Benet LZ, Lin ET. Stereoselective disposition of ketoprofen in rats. Drug Metab Dispos. 1991 May-Jun; 19(3):717-8. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Gumbleton M, Benet LZ. Drug metabolism and laboratory anesthetic protocols in the rat: examination of antipyrine pharmacokinetics. Pharm Res. 1991 Apr; 8(4):544-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lau DT, Gumbleton M, Labisch C, Benet LZ. Pharmacokinetic studies of the nitroglycerin metabolites, 1,2- and 1,3- glyceryl dinitrates, in the rat. Biopharm Drug Dispos. 1991 Apr; 12(3):215-22. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Rho Chi Lecture. Ideals and innovation: drugs, generics, the FDA, and the pharmacist. DICP. 1991 Apr; 25(4):427-30. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gumbleton M, Benet LZ. Pharmacological activity of the dinitrate metabolites of nitroglycerin following their oral administration to healthy volunteers. Br J Clin Pharmacol. 1991 Feb; 31(2):211-3. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Volland C, Benet LZ. In vitro enantioselective glucuronidation of fenoprofen. Pharmacology. 1991; 43(2):53-60. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Hale VG, Benet LZ. Prednisolone and prednisone exhibit linear extraction in the perfused rabbit liver. Drug Metab Dispos. 1991 Jan-Feb; 19(1):87-93. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Safety and pharmacokinetics: colloidal bismuth subcitrate. Scand J Gastroenterol Suppl. 1991; 185:29-35. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Volland C, Sun H, Benet LZ. Stereoselective analysis of fenoprofen and its metabolites. J Chromatogr. 1990 Dec 14; 534:127-38. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Lee FW, Salmonson T, Metzler CH, Benet LZ. Pharmacokinetics and pharmacodynamics of glyceryl trinitrate and its two dinitrate metabolites in conscious dogs. J Pharmacol Exp Ther. 1990 Dec; 255(3):1222-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Smith PC, Benet LZ, McDonagh AF. Covalent binding of zomepirac glucuronide to proteins: evidence for a Schiff base mechanism. Drug Metab Dispos. 1990 Sep-Oct; 18(5):639-44. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Skelley JP, Amidon GL, Barr WH, Benet LZ, Carter JE, Robinson JR, Shah VP, Yacobi A. Report of the workshop on in vitro and in vivo testing and correlation for oral controlled/modified-release dosage forms. J Pharm Sci. 1990 Sep; 79(9):849-54. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Manfro RC, Pohanka E, Tomlanovich SJ, Benet LZ, Salvatierra O, Garovoy MR. Determination of soluble IL-2 receptors in kidney graft recipients--a 6-month follow-up. Transplant Proc. 1990 Aug; 22(4):1861-2. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Gupta SK, Manfro RC, Tomlanovich SJ, Gambertoglio JG, Garovoy MR, Benet LZ. Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration. J Clin Pharmacol. 1990 Jul; 30(7):643-53. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lau DT, Benet LZ. Nitroglycerin metabolism in subcellular fractions of rabbit liver. Dose dependency of glyceryl dinitrate formation and possible involvement of multiple isozymes of glutathione S-transferases. Drug Metab Dispos. 1990 May-Jun; 18(3):292-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Nakashima E, Rigod JF, Lin ET, Benet LZ. Pharmacokinetics of nitroglycerin and its dinitrate metabolites over a thirtyfold range of oral doses. Clin Pharmacol Ther. 1990 May; 47(5):592-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Williams RL, Lin ET, Liang-Gee W, Blume CD, Benet LZ. Absorption and disposition of a new low-dose combination formulation of hydrochlorothiazide and triamterene. Biopharm Drug Dispos. 1990 Apr; 11(3):233-43. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Hamamoto K, Iwamoto HS, Roman CM, Benet LZ, Rudolph AM. Fetal uptake of intraamniotic digoxin in sheep. Pediatr Res. 1990 Mar; 27(3):282-5. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Iwakawa S, Spahn H, Benet LZ, Lin ET. Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin. Biochem Pharmacol. 1990 Mar 01; 39(5):949-53. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Wang LH, Rudolph AM, Benet LZ. Comparative study of acetaminophen disposition in sheep at three developmental stages: the fetal, neonatal and adult periods. Dev Pharmacol Ther. 1990; 14(3):161-79. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Smith PC, McDonagh AF, Benet LZ. Effect of esterase inhibition on the disposition of zomepirac glucuronide and its covalent binding to plasma proteins in the guinea pig. J Pharmacol Exp Ther. 1990 Jan; 252(1):218-24. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Gupta SK, Benet LZ. High-fat meals increase the clearance of cyclosporine. Pharm Res. 1990 Jan; 7(1):46-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Munafo A, McDonagh AF, Smith PC, Benet LZ. Irreversible binding of tolmetin glucuronic acid esters to albumin in vitro. Pharm Res. 1990 Jan; 7(1):21-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Steffe EM, King JH, Inciardi JF, Flynn NF, Goldstein E, Tonjes TS, Benet LZ. The effect of acetaminophen on zidovudine metabolism in HIV-infected patients. J Acquir Immune Defic Syndr (1988). 1990; 3(7):691-4. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Nakashima E, Benet LZ. An integrated approach to pharmacokinetic analysis for linear mammillary systems in which input and exit may occur in/from any compartment. J Pharmacokinet Biopharm. 1989 Dec; 17(6):673-86. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Ding RW, Kolbe K, Merz B, de Vries J, Weber E, Benet LZ. Pharmacokinetics of nicotinic acid-salicylic acid interaction. Clin Pharmacol Ther. 1989 Dec; 46(6):642-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gupta SK, Benet LZ. Absorption kinetics of cyclosporine in healthy volunteers. Biopharm Drug Dispos. 1989 Nov-Dec; 10(6):591-6. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Watari N, Benet LZ. Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs. J Pharmacokinet Biopharm. 1989 Oct; 17(5):593-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Teng RL, Benet LZ. Simultaneous measurement of prednisone, prednisolone and 6 beta-hydroxyprednisolone in urine by high-performance liquid chromatography using dexamethasone as the internal standard. J Chromatogr. 1989 Sep 01; 493(2):421-3. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Bois FY, Tozer TN, Zeise L, Benet LZ. Application of clearance concepts to the assessment of exposure to lead in drinking water. Am J Public Health. 1989 Jul; 79(7):827-31. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Iwakawa S, Suganuma T, Lee SF, Spahn H, Benet LZ, Lin ET. Direct determination of diastereomeric carprofen glucuronides in human plasma and urine and preliminary measurements of stereoselective metabolic and renal elimination after oral administration of carprofen in man. Drug Metab Dispos. 1989 Jul-Aug; 17(4):414-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Bois FY, Tozer TN, Benet LZ, Zeise L. Lead exposure in children vs adults. Am J Public Health. 1989 Jul; 79(7):904. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Koshida R, Nakashima E, Taniguchi N, Tsuji A, Benet LZ, Ichimura F. Prediction of the distribution volumes of cefazolin and tobramycin in obese children based on physiological pharmacokinetic concepts. Pharm Res. 1989 Jun; 6(6):486-91. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Spahn H, Spahn I, Benet LZ. Probenecid-induced changes in the clearance of carprofen enantiomers: a preliminary study. Clin Pharmacol Ther. 1989 May; 45(5):500-5. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gloff CA, Benet LZ. Differential effects of the degree of renal damage on p-aminohippuric acid and inulin clearances in rats. J Pharmacokinet Biopharm. 1989 Apr; 17(2):169-77. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Manfro RC, Pohanka E, Tomlanovich S, Benet LZ, Garovoy MR. Cyclosporin A and prednisolone: an additive inhibitory effect of cell proliferation and interleukin-2 production. Transplant Proc. 1989 Feb; 21(1 Pt 2):1457-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lau DT, Benet LZ. Differential formation of dinitrate metabolites from glyceryl trinitrate in subcellular fractions of rabbit liver. Biochem Pharmacol. 1989 Feb 01; 38(3):543-6. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Hammarlund-Udenaes M, Benet LZ. Furosemide pharmacokinetics and pharmacodynamics in health and disease--an update. J Pharmacokinet Biopharm. 1989 Feb; 17(1):1-46. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Spahn H, Iwakawa S, Lin ET, Benet LZ. Procedures to characterize in vivo and in vitro enantioselective glucuronidation properly: studies with benoxaprofen glucuronides. Pharm Res. 1989 Feb; 6(2):125-32. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Spahn H, Spahn I, Pflugmann G, Mutschler E, Benet LZ. Measurement of carprofen enantiomer concentrations in plasma and urine using L-leucinamide as the chiral coupling component. J Chromatogr. 1988 Dec 09; 433:331-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Yu DK, Williams RL, Benet LZ, Lin ET, Giesing DH. Pharmacokinetics of nitroglycerin and metabolites in humans following oral dosing. Biopharm Drug Dispos. 1988 Nov-Dec; 9(6):557-65. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Nakashima E, Benet LZ. General treatment of mean residence time, clearance, and volume parameters in linear mammillary models with elimination from any compartment. J Pharmacokinet Biopharm. 1988 Oct; 16(5):475-92. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gawienowski M, Benet LZ, Fleckenstein L, Lin ET. Ion-paired liquid chromatographic method for the analysis of blood and plasma for the antimalarial drug halofantrine and its putative mono-debutylated metabolite. J Chromatogr. 1988 Sep 09; 430(2):412-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Hyneck ML, Smith PC, Munafo A, McDonagh AF, Benet LZ. Disposition and irreversible plasma protein binding of tolmetin in humans. Clin Pharmacol Ther. 1988 Jul; 44(1):107-14. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Schwartz JB, Upton RA, Lin ET, Williams RL, Benet LZ. Effect of cimetidine or ranitidine administration on nifedipine pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 1988 Jun; 43(6):673-80. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Lee FW, Watari N, Rigod J, Benet LZ. Simultaneous determination of nitroglycerin and its dinitrate metabolites by capillary gas chromatography with electron-capture detection. J Chromatogr. 1988 Apr 29; 426(2):259-66. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Hyneck ML, Munafo A, Benet LZ. Effect of pH on acyl migration and hydrolysis of tolmetin glucuronide. Drug Metab Dispos. 1988 Mar-Apr; 16(2):322-4. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Gloff CA, Mamelok RD, Benet LZ. Organic anion transport by basal-lateral membranes: effect of PAH and furosemide on each other's transport. Pharmacology. 1988; 37(4):268-76. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Hyneck ML, Smith PC, Unseld E, Benet LZ. High-performance liquid chromatographic determination of tolmetin, tolmetin glucuronide and its isomeric conjugates in plasma and urine. J Chromatogr. 1987 Sep 25; 420(2):349-56. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Noonan PK, Benet LZ. Variable glyceryl dinitrate formation as a function of route of nitroglycerin administration. Clin Pharmacol Ther. 1987 Sep; 42(3):273-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Williams RL, Mordenti J, Upton RA, Lin ET, Gee WL, Blume CD, Benet LZ. Effects of formulation and food on the absorption of hydrochlorothiazide and triamterene or amiloride from combination diuretic products. Pharm Res. 1987 Aug; 4(4):348-52. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Nakashima E, Noonan PK, Benet LZ. Transdermal bioavailability and first-pass skin metabolism: a preliminary evaluation with nitroglycerin. J Pharmacokinet Biopharm. 1987 Aug; 15(4):423-37. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Ferraiolo BL, Halldin MM, Asscher Y, Akita Y, Melmon KL, Benet LZ, Castagnoli N. Pharmacokinetics and excretion of unique beta-adrenergic agonists. Pharmacology. 1987; 34(2-3):157-66. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Wang LH, Zakim D, Rudolph AM, Benet LZ. Developmental alterations in hepatic UDP-glucuronosyltransferase. A comparison of the kinetic properties of enzymes from adult sheep and fetal lambs. Biochem Pharmacol. 1986 Sep 15; 35(18):3065-70. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. AAPS and pharmaceutical research. Pharm Res. 1986 Aug; 3(4):186. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Williams RL, Thornhill MD, Upton RA, Blume C, Clark TS, Lin E, Benet LZ. Absorption and disposition of two combination formulations of hydrochlorothiazide and triamterene: influence of age and renal function. Clin Pharmacol Ther. 1986 Aug; 40(2):226-32. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Smith PC, Benet LZ. Characterization of the isomeric esters of zomepirac glucuronide by proton NMR. Drug Metab Dispos. 1986 Jul-Aug; 14(4):503-5. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Varughese A, Brater DC, Benet LZ, Lee CS. Ethambutol kinetics in patients with impaired renal function. Am Rev Respir Dis. 1986 Jul; 134(1):34-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Wang LH, Rudolph AM, Benet LZ. Pharmacokinetic studies of the disposition of acetaminophen in the sheep maternal-placental-fetal unit. J Pharmacol Exp Ther. 1986 Jul; 238(1):198-205. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Shi RJ, Benet LZ, Lin ET. High-performance liquid chromatographic assay of basic amine drugs in plasma and urine using a silica gel column and an aqueous mobile phase. I. Amiloride. J Chromatogr. 1986 Apr 25; 377:399-404. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Legler UF, Benet LZ. Marked alterations in dose-dependent prednisolone kinetics in women taking oral contraceptives. Clin Pharmacol Ther. 1986 Apr; 39(4):425-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Smith PC, McDonagh AF, Benet LZ. Irreversible binding of zomepirac to plasma protein in vitro and in vivo. J Clin Invest. 1986 Mar; 77(3):934-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Noonan PK, Benet LZ. The bioavailability of oral nitroglycerin. J Pharm Sci. 1986 Mar; 75(3):241-3. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Sörgel F, Ettinger B, Benet LZ. Metabolic fate and solubility of triamterene--not an explanation for triamterene nephrolithiasis. J Pharm Sci. 1986 Feb; 75(2):129-32. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gustavson LE, Legler UF, Benet LZ. Impairment of prednisolone disposition in women taking oral contraceptives or conjugated estrogens. J Clin Endocrinol Metab. 1986 Jan; 62(1):234-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Legler UF, Benet LZ. The effect of prednisone and hydrocortisone on the plasma protein binding of prednisolone in man. Eur J Clin Pharmacol. 1986; 30(1):51-5. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gustavson LE, Benet LZ. The macromolecular binding of prednisone in plasma of healthy volunteers including pregnant women and oral contraceptive users. J Pharmacokinet Biopharm. 1985 Dec; 13(6):561-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Wang LH, Rudolph AM, Benet LZ. Distribution and fate of acetaminophen conjugates in fetal lambs in utero. J Pharmacol Exp Ther. 1985 Nov; 235(2):302-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Sheiner LB, Benet LZ. Premarketing observational studies of population pharmacokinetics of new drugs. Clin Pharmacol Ther. 1985 Nov; 38(5):481-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Mean residence time in the body versus mean residence time in the central compartment. J Pharmacokinet Biopharm. 1985 Oct; 13(5):555-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Smith PC, Langendijk PN, Bosso JA, Benet LZ. Effect of probenecid on the formation and elimination of acyl glucuronides: studies with zomepirac. Clin Pharmacol Ther. 1985 Aug; 38(2):121-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Ferraiolo BL, Benet LZ. Peptides and proteins as drugs. Pharm Res. 1985 Jul; 2(4):151-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Noonan PK, Williams RL, Benet LZ. Dose dependent pharmacokinetics of nitroglycerin after multiple intravenous infusions in healthy volunteers. J Pharmacokinet Biopharm. 1985 Apr; 13(2):143-57. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Pharmacokinetics and metabolism of bepridil. Am J Cardiol. 1985 Mar 15; 55(7):8C-13C. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Tsang SY, Garovoy MR, Benet LZ. Immunosuppressive activity of prednisone and prednisolone and their metabolic interconversion in the mixed lymphocyte reaction. Int J Immunopharmacol. 1985; 7(5):731-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Noonan PK, Benet LZ. Incomplete and delayed bioavailability of sublingual nitroglycerin. Am J Cardiol. 1985 Jan 01; 55(1):184-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Wang LH, Rudolph AM, Benet LZ. Pharmacokinetics of drugs and metabolites in the maternal-placental-fetal unit: general principles. NIDA Res Monogr. 1985; 60:25-38. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Smith PC, Hasegawa J, Langendijk PN, Benet LZ. Stability of acyl glucuronides in blood, plasma, and urine: studies with zomepirac. Drug Metab Dispos. 1985 Jan-Feb; 13(1):110-2. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Upton RA, Williams RL, Lin ET, Gee WL, Blume CD, Benet LZ. Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered. J Pharmacokinet Biopharm. 1984 Dec; 12(6):575-86. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Blume CD, Williams RL, Upton RA, Lin ET, Benet LZ. Bioequivalence study of a new tablet formulation of triamterene and hydrochlorothiazide. Am J Med. 1984 Nov 05; 77(5A):59-61. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Noonan PK, Kanfer I, Riegelman S, Benet LZ. Determination of picogram nitroglycerin plasma concentrations using capillary gas chromatography with on-column injection. J Pharm Sci. 1984 Jul; 73(7):923-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Sörgel F, Lin ET, Hasegawa J, Benet LZ. Liquid chromatographic analysis of triamterene and its major metabolite, hydroxytriamterene sulfate, in blood, plasma, and urine. J Pharm Sci. 1984 Jun; 73(6):831-3. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Langendijk PN, Smith PC, Hasegawa J, Benet LZ. Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine. J Chromatogr. 1984 May 11; 307(2):371-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Smith PC, Benet LZ. High-performance liquid chromatographic method for the determination of indomethacin and its two primary metabolites in urine. J Chromatogr. 1984 Mar 09; 306:315-21. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Chiang CW, Benet LZ. Dose-dependent kinetics of probenecid in rhesus monkeys--infusion studies. Pharmacology. 1984; 28(4):181-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Pharmacokinetic parameters: which are necessary to define a drug substance? Eur J Respir Dis Suppl. 1984; 134:45-61. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Meister W, Benowitz NL, Benet LZ. Unchanged absorption of digoxin tablets in patients with cardiac failure. Pharmacology. 1984; 28(2):90-4. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Baughman RA, Sorgel F, Mico BA, Benet LZ. Dose-dependent bioavailability of prazosin in beagle dogs. J Cardiovasc Pharmacol. 1983 Jul-Aug; 5(4):613-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Park GB, Kershner RP, Angellotti J, Williams RL, Benet LZ, Edelson J. Oral bioavailability and intravenous pharmacokinetics of amrinone in humans. J Pharm Sci. 1983 Jul; 72(7):817-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Lozada F, Frey FJ, Benet LZ. Prednisolone clearance: a possible determinant for glucocorticoid efficacy in patients with oral vesiculo-erosive diseases. J Dent Res. 1983 May; 62(5):575-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Smith DE, Lin ET, Vincenti F, Gambertoglio JG. Furosemide assays and disposition in healthy volunteers and renal transplant patients. Fed Proc. 1983 Apr; 42(6):1695-8. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Baughman RA, Mico BA, Benet LZ. The bioavailability and disposition of tiodazosin levulinate in beagle dogs with a comparison to prazosin hydrochloride. Drug Metab Dispos. 1983 Mar-Apr; 11(2):143-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Smith DE, Benet LZ. Biotransformation of furosemide in kidney transplant patients. Eur J Clin Pharmacol. 1983; 24(6):787-90. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Smith DE, Benet LZ. Plasma protein binding of furosemide in kidney transplant patients. J Pharmacokinet Biopharm. 1982 Dec; 10(6):663-74. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Frey FJ, Amend WJ, Lozada F, Frey BM. Endogenous and exogenous glucocorticoids in cushingoid patients. Drug Intell Clin Pharm. 1982 Nov; 16(11):863-8. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> O'Neill PJ, Yorgey KA, Renzi NL, Williams RL, Benet LZ. Disposition of zomepirac sodium in man. J Clin Pharmacol. 1982 Oct; 22(10):470-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Hasegawa J, Lin ET, Williams RL, Sörgel F, Benet LZ. Pharmacokinetics of triamterene and its metabolite in man. J Pharmacokinet Biopharm. 1982 Oct; 10(5):507-23. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Legler UF, Frey FJ, Benet LZ. Prednisolone clearance at steady state in man. J Clin Endocrinol Metab. 1982 Oct; 55(4):762-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Hasegawa J, Smith PC, Benet LZ. Apparent intramolecular acyl migration of zomepirac glucuronide. Drug Metab Dispos. 1982 Sep-Oct; 10(5):469-73. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Buskin JN, Upton RA, Sörgel F, Williams RL, Lang E, Benet LZ. Specific and sensitive assay of celiprolol in blood, plasma and urine using high-performance liquid chromatography. J Chromatogr. 1982 Jul 09; 230(2):454-60. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Mico BA, Baughman RA, Benet LZ. Determination of tiodazosin in plasma and whole blood by high-performance liquid chromatography. J Chromatogr. 1982 Jun 11; 230(1):203-6. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Frey BM, Frey FJ, Holford NH, Lozada F, Benet LZ. Prednisolone pharmacodynamics assessed by inhibition of the mixed lymphocyte reaction. Transplantation. 1982 Jun; 33(6):578-84. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Williams RL, Blume CD, Lin ET, Holford NH, Benet LZ. Relative bioavailability of chlorthalidone in humans: adverse influence of polyethylene glycol. J Pharm Sci. 1982 May; 71(5):533-5. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Williams RL, Davies RO, Berman RS, Holmes GI, Huber P, Gee WL, Lin ET, Benet LZ. Hydrochlorothiazide pharmacokinetics and pharmacologic effect: the influence of indomethacin. J Clin Pharmacol. 1982 Jan; 22(1):32-41. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Frey FJ, Gambertoglio JG, Frey BM, Benet LZ, Amend WJ. Nonlinear plasma protein binding and haemodialysis clearance of prednisolone. Eur J Clin Pharmacol. 1982; 23(1):65-74. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Williams RL, Furst DE, Mandel HG, Nicoll D, Konikoff JJ, Benet LZ. Effects of indomethacin and carprofen on renal homeostasis in rheumatoid arthritis patients and in healthy individuals. J Clin Pharmacol. 1981 Nov-Dec; 21(11):493-500. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Frey FJ, Amend WJ, Lozada F, Frey BM, Benet LZ. Endogenous hydrocortisone, a possible factor contributing to the genesis of cushingoid habitus in patients on prednisone. J Clin Endocrinol Metab. 1981 Nov; 53(5):1076-80. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Mamelok RD, Macrae DR, Benet LZ, Prusiner SB. Membrane populations of bovine choroid plexus: separation by density gradient centrifugation in modified colloidal silica. J Neurochem. 1981 Sep; 37(3):768-74. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gustafson JH, Benet LZ. Saturable kinetics of intravenous chlorothiazide in the rhesus monkey. J Pharmacokinet Biopharm. 1981 Aug; 9(4):461-76. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Smith DE, Gambertoglio JG, Vincenti F, Benet LZ. Furosemide kinetics and dynamics after kidney transplant. Clin Pharmacol Ther. 1981 Jul; 30(1):105-13. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Sheiner LB, Benet LZ, Pagliaro LA. A standard approach to compiling clinical pharmacokinetic data. J Pharmacokinet Biopharm. 1981 Feb; 9(1):59-127. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Chiang CW, Benet LZ. Dose-dependent kinetics of probenecid in rhesus monkeys-intravenous bolus studies. Pharmacology. 1981; 23(6):326-36. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Frey FJ, Amend WJ, Lozada F, Frey BM, Holford NH, Benet LZ. Pharmacokinetics of prednisolone and endogenous hydrocortisone levels in cushingoid and non-cushingoid patients. Eur J Clin Pharmacol. 1981; 21(3):235-42. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Frey BM, Frey FJ, Cochrum KC, Benet LZ. Induction kinetics of human suppressor cells in the mixed lymphocyte reaction and influence of prednisolone on their genesis. Cell Immunol. 1980 Nov; 56(1):225-34. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Frey FJ, Frey BM, Greither A, Benet LZ. Prednisolone clearance at steady state in dogs. J Pharmacol Exp Ther. 1980 Nov; 215(2):287-91. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Brater DC, Kaojarern S, Benet LZ, Lin ET, Lockwood T, Morris RC, McSherry EJ, Melmon KL. Renal excretion of pseudoephedrine. Clin Pharmacol Ther. 1980 Nov; 28(5):690-4. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lin ET, Baughman RA, Benet LZ. High-performance liquid chromatographic determination of prazosin in human plasma, whole blood and urine. J Chromatogr. 1980 Sep 12; 183(3):367-71. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Smith DE, Lin ET, Benet LZ. Absorption and disposition of furosemide in healthy volunteers, measured with a metabolite-specific assay. Drug Metab Dispos. 1980 Sep-Oct; 8(5):337-42. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lee CS, Brater DC, Gambertoglio JG, Benet LZ. Disposition kinetics of ethambutol in man. J Pharmacokinet Biopharm. 1980 Aug; 8(4):335-46. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Baughman RA, Arnold S, Benet LZ, Lin ET, Chatterjee K, Williams RL. Altered prazosin pharmacokinetics in congestive heart failure. Eur J Clin Pharmacol. 1980 Jun; 17(6):425-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Smith DE, Gee WL, Brater DC, Lin ET, Benet LZ. Preliminary evaluation of furosemide-probenecid interaction in humans. J Pharm Sci. 1980 May; 69(5):571-5. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Lee CS, Marbury TC, Benet LZ. Clearance calculations in hemodialysis: application to blood, plasma, and dialysate measurements for ethambutol. J Pharmacokinet Biopharm. 1980 Feb; 8(1):69-81. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Schmitt JK, Davis JL, Lorenzi M, Benet LZ, Burns A, Karam JH. Inhibition by indomethacin of the glycemic response to arginine in man. Proc Soc Exp Biol Med. 1980 Feb; 163(2):237-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Gambertoglio JG, Amend WJ, Benet LZ. Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: a review. J Pharmacokinet Biopharm. 1980 Feb; 8(1):1-52. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Williams RL, Benet LZ. Drug pharmacokinetics in cardiac and hepatic disease. Annu Rev Pharmacol Toxicol. 1980; 20:389-413. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Till AE, Benet LZ. Renal excretion of pseudoephedrine in the rat. J Pharmacol Exp Ther. 1979 Dec; 211(3):555-60. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gambertoglio JG, Aziz NS, Lin ET, Grausz H, Naughton JL, Benet LZ. Cefamandole kinetics in uremic patients undergoing hemodialysis. Clin Pharmacol Ther. 1979 Nov; 26(5):592-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Ding TL, Benet LZ. Comparative bioavailability and pharmacokinetic studies of azathioprine and 6-mercaptopurine in the rhesus monkey. Drug Metab Dispos. 1979 Nov-Dec; 7(6):373-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Frey FJ, Frey BM, Benet LZ. Liquid-chromatographic measurement of endogenous and exogenous glucocorticoids in plasma. Clin Chem. 1979 Nov; 25(11):1944-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Arnold SB, Williams RL, Ports TA, Baughman RA, Benet LZ, Parmley WW, Chatterjee K. Attenuation of prazosin effect on cardiac output in chronic heart failure. Ann Intern Med. 1979 Sep; 91(3):345-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Galeazzi RL. Noncompartmental determination of the steady-state volume of distribution. J Pharm Sci. 1979 Aug; 68(8):1071-4. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Ding TL, Benet LZ. Determination of 6-mercaptopurine and azathioprine in plasma by high-performance liquid chromatography. J Chromatogr. 1979 Jul 21; 163(3):281-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lin ET, Smith DE, Benet LZ, Hoener BA. High-performance liquid chromatographic assays for furosemide in plasma and urine. J Chromatogr. 1979 Jul 21; 163(3):315-21. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Smith DE, Brater DC, Lin ET, Benet LZ. Attenuation of furosemide's diuretic effect by indomethacin: pharmacokinetic evaluation. J Pharmacokinet Biopharm. 1979 Jun; 7(3):265-74. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Pharmacokinetics/pharmacodynamics of furosemide in man: a review. J Pharmacokinet Biopharm. 1979 Feb; 7(1):1-27. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Greither A, Goldman S, Edelen JS, Benet LZ, Cohn K. Pharmacokinetics of furosemide in patients with congestive heart failure. Pharmacology. 1979; 19(3):121-31. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Till AE, Benet LZ. Pseudoephedrine pharmacokinetics in the rat using a microanalysis technique. Pharmacology. 1979; 18(6):306-10. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Smith DE, Benet LZ. Relationship between urinary excretion rate, steady-state plasma levels and diuretic response of furosemide in the rat. Pharmacology. 1979; 19(6):301-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. Effect of route of administration and distribution on drug action. J Pharmacokinet Biopharm. 1978 Dec; 6(6):559-85. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Ham J, Miller RD, Benet LZ, Matteo RS, Roderick LL. Pharmacokinetics and pharmacodynamics of d-tubocurarine during hypothermia in the cat. Anesthesiology. 1978 Nov; 49(5):324-9. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lee CS, Benet LZ. Micro and macro GLC determination of ethambutol in biological fluids. J Pharm Sci. 1978 Apr; 67(4):470-3. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Aziz NS, Gambertoglio JG, Lin ET, Grausz H, Benet LZ. Pharmacokinetics of cefamandole using a HPLC assay. J Pharmacokinet Biopharm. 1978 Apr; 6(2):153-64. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Stalker NE, Gambertoglio JG, Fukumitsu CJ, Naughton JL, Benet LZ. Acute massive chloral hydrate intoxication treated with hemodialysis: a clinical pharmacokinetic analysis. J Clin Pharmacol. 1978 Feb-Mar; 18(2-3):136-42. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Barnett G, Lockwood T, Arancibia A, Benet LZ. Ascorbate stimulation of salicylate absorption in isolated rat intestine. J Pharm Sci. 1978 Feb; 67(2):224-6. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Peck CC, Benet LZ. General method for determining macrodissociation constants of polyprotic, amphoteric compounds from solubility measurements. J Pharm Sci. 1978 Jan; 67(1):12-6. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> García CR, Siqueiros A, Benet LZ. Oral controlled release preparations. Pharm Acta Helv. 1978; 53(3-4):99-109. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Ding TL, Lin ET, Benet LZ. The reversible biotransformation of N-acetylprocainamide in the rhesus monkey. Arzneimittelforschung. 1978; 28(2):281-3. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Lee CS, Gambertoglio JG, Brater DC, Benet LZ. Kinetics of oral ethambutol in the normal subject. Clin Pharmacol Ther. 1977 Nov; 22(5 Pt 1):615-21. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Lin ET, Brater DC, Benet LZ. Gas-liquid chromatographic determination of pseudoephedrine and norpseudoephedrine in human plasma and urine. J Chromatogr. 1977 Oct 21; 140(3):275-9. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Miller RD, Matteo RS, Benet LZ, Sohn YJ. The pharmacokinetics of d-tubocurarine in man with and without renal failure. J Pharmacol Exp Ther. 1977 Jul; 202(1):1-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Ronfeld RA, Benet LZ. Interpretation of plasma concentration-time curves after oral dosing. J Pharm Sci. 1977 Feb; 66(2):178-80. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Lee CS, Benet LZ. Gas-liquid chromatographic determination of ethambutol in plasma and urine of man and monkey. J Chromatogr. 1976 Nov 17; 128(1):188-92. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Galeazzi RL, Benet LZ, Sheiner LB. Relationship between the pharmacokinetics and pharmacodynamics of procainamide. Clin Pharmacol Ther. 1976 Sep; 20(3):278-89. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Galeazzi RL, Benet LZ. Inappropriate use of the law of corresponding areas to calculate the time course of absorption for multicompartmental systems. J Pharmacokinet Biopharm. 1976 Feb; 4(1):43-56. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Gustafson JH, Schoenwald RD, Benet LZ. Limitations in interpretation of digoxin adsorption using averaged pharmacological response intensities. J Pharm Sci. 1976 Feb; 65(2):243-7. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Galeazzi RL, Sheiner LB, Lockwood T, Benet LZ. The renal elimination of procainamide. Clin Pharmacol Ther. 1976 Jan; 19(1):55-62. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Pagliaro LA, Benet LZ. Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with references. J Pharmacokinet Biopharm. 1975 Oct; 3(5):333-83. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Orr JM, Benet LZ. The effect of fasting on the rate of intestinal drug absorption in rats: preliminary studies. Am J Dig Dis. 1975 Sep; 20(9):858-65. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Till AE, Benet LZ, Kwan KC. An integrated approach to the pharmacokinetic analysis of drug absorption. J Pharmacokinet Biopharm. 1974 Dec; 2(6):525-44. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Gustafson JH, Benet LZ. Biliary excretion kinetics of phenolphthalein glucuronide after intravenous and retrograde biliary administration. J Pharm Pharmacol. 1974 Dec; 26(12):937-44. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Nayak RK, Benet LZ. Use of the unanesthetized rhesus monkey as a model for studying the gastrointestinal absorption of drugs. J Pharmacokinet Biopharm. 1974 Oct; 2(5):417-31. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Rowland M, Benet LZ, Graham GG. Clearance concepts in pharmacokinetics. J Pharmacokinet Biopharm. 1973 Apr; 1(2):123-36. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Wolfe DL, Forland SC, Benet LZ. Drug transfer across intact rat intestinal mucosa following surgical removal of serosa and muscularis externa. J Pharm Sci. 1973 Feb; 62(2):200-5. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Nelson JA, Moss AA, Goldberg HI, Benet LZ, Amberg J. Gastrointestinal absorption of iopanoic acid. Invest Radiol. 1973 Jan-Feb; 8(1):1-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ. General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics. J Pharm Sci. 1972 Apr; 61(4):536-41. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Nayak RK, Benet LZ. Drug transfer across rat intestinal musculature after edetic acid treatment. J Pharm Sci. 1971 Oct; 60(10):1508-11. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Turi JS. Use of general partial fraction theorem for obtaining inverse laplace transforms in pharmacokinetic analysis. J Pharm Sci. 1971 Oct; 60(10):1593-4. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Orr JM, Turner RH, Webb HS. Effect of buffer constituents and time on drug transfer across in vitro rat intestine. J Pharm Sci. 1971 Feb; 60(2):234-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Turner RH, Mehta CS, Benet LZ. Apparent directional permeability coefficients for drug ions: in vitro intestinal perfusion studies. J Pharm Sci. 1970 May; 59(5):590-5. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Rowland M, Benet LZ, Riegelman S. Two-compartment model for a drug and its metabolite: application to acetylsalicylic acid pharmacokinetics. J Pharm Sci. 1970 Mar; 59(3):364-7. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Ronfeld RA. Volume terms in pharmacokinetics. J Pharm Sci. 1969 May; 58(5):639-41. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Goyan JE. Potentiometric determination of dissociation constants. J Pharm Sci. 1967 Jun; 56(6):665-80. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Goyan JE. Thermodynamics of chelation by tetracyclines. J Pharm Sci. 1966 Nov; 55(11):1184-90. </td> </tr> <tr class="odd"> <td class="views-field views-field-field-person-publications-list"> Singh P, Guillory JK, Sokoloski TD, Benet LZ, Bhatia VN. Effect of inert tablet ingredients on drug absorption. I. Effect of polyethylene glycol 4000 on the intestinal absorption of four barbiturates. J Pharm Sci. 1966 Jan; 55(1):63-8. </td> </tr> <tr class="even"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Goyan JE. Nonlogarithmic titration curves for the determination of dissociation constants and purity. J Pharm Sci. 1965 Aug; 54(8):1179-82. </td> </tr> <tr class="odd views-row-last"> <td class="views-field views-field-field-person-publications-list"> Benet LZ, Goyan JE. Determination of the stability constants of tetracycline complexes. J Pharm Sci. 1965 Jul; 54(7):983-7. </td> </tr> </tbody> </table> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div>  </div>  </div>  </div>  </div>  <div role="complementary" class="footer-make-a-gift-and-quote"> <div class="footer-make-a-gift"> <a href="https://makeagift.ucsf.edu/site/SPageServer?pagename=A1_API_GeneralGivingForm&Primary=Pharmacy">Make a gift</a> </div> <div class="footer-quote"> Science is the foundation of the School of Pharmacy’s pioneering research, individualized patient care, and unparalleled PharmD and PhD education programs. </div> </div> <div class="footer-wrapper-outer" role="contentinfo"> <div class="footer-wrapper-inner"> <div class="footer-site-names-and-disclaimer"> </div> <div class="footer menu"> <ul id="footer-menu" class="links clearfix footer-menu"><li class="0 first"><a href="https://pharmacy.ucsf.edu/suggestions" title="">Suggestions</a></li> <li class="1"><a href="https://pharmacy.ucsf.edu/support?reporturl=https%3A//pharmacy.ucsf.edu/leslie-benet" title="">Report a problem</a></li> <li class="menu-18196"><a href="/about/contact" title="">Contact us</a></li> <li class="menu-91601"><a href="https://websites.ucsf.edu/digital-accessibility" title="">Accessibility</a></li> <li class="menu-91606"><a href="https://www.ucsf.edu/website-privacy-policy" title="">Privacy policy</a></li> <li class="menu-91611"><a href="https://websites.ucsf.edu/website-terms-use" title="">Terms of use</a></li> <li class="menu-91616"><a href="https://websites.ucsf.edu/azlist" title="">A-Z website list</a></li> <li class="menu-7861 last"><a href="/saml_login?destination=leslie-benet" title="" rel="nofollow">Log in</a></li> </ul> </div> <div class="footer-social"> <div class="item-list"><ul><li class="first"><a href="https://www.facebook.com/ucsfpharmacy" class="facebook">Facebook</a></li> <li><a href="https://www.youtube.com/@ucsfpharmacy" class="youtube">YouTube</a></li> <li><a href="https://www.linkedin.com/showcase/ucsf-school-of-pharmacy" class="linkedin">LinkedIn</a></li> <li><a href="https://x.com/ucsfpharmacy" class="twitter">X</a></li> <li class="last"><a href="https://www.instagram.com/ucsfpharmacy/" class="instagram">Instagram</a></li> </ul></div> </div> <div class="copyright"> © 2002–2024 The Regents of the University of California </div> </div> </div> <script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script><script type="text/javascript" src="/sites/pharmacy.ucsf.edu/files/advagg_js/js__GM3GJPR36rRIz0TRkjC5OQwrioSyN9aoYRivDhCO_AM__qAl84FcCv2jyN22yFGS5Oc85cjd9zKX6p_cFNLGhe-M__seqvHfaz3fVlgbfb4sGxYkGyco2BfGnhCPlf7TXVcuY.js" async="async"></script> <script type="text/javascript" src="/sites/pharmacy.ucsf.edu/files/advagg_js/js__BXT3KPF6ph4oEqAPjWiNmzlSjlQ9cW6B36GuZ8Knzt8__kNEvQrCieBaWSkG2Yi7cvf5o5n825wJD1XixHxWBUFo__seqvHfaz3fVlgbfb4sGxYkGyco2BfGnhCPlf7TXVcuY.js"></script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"3132ed34d6","applicationID":"70694569","transactionName":"YFRUNUpZDUdUUEddV1kedRRLTAxZGkNSU11oXFcPWV8GRmpdXFBdaEdfBE9nE1VSVhxBW0RXaRFdShBbWw==","queueTime":9,"applicationTime":1426,"atts":"TBNXQwJDHkk=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>

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Leslie Benet, PhD · School of Pharmacy · UCSF