Current Issue | PLOS Biology

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search" class="search-icon"></i> </button> </div> </fieldset> <input type="hidden" name="filterJournals" value="PLoSBiology"/> </form> <a id="advSearch" href="/plosbiology/search"> advanced search </a> <script src="/resource/js/components/placeholder_style.js" type="text/javascript"></script> </li> </ul> </section> </nav> </div> </header> <main id="main-content"> <section > <small class="item-title lead-in">Table of Contents</small> <h2>January 2025</h2> <nav id="nav-toc"> <ul class="nav-page"> <li data-toc="Cover"><a href="#Cover">Cover</a></li> <li data-toc="Unsolved_Mystery"><a href="#Unsolved_Mystery">Unsolved Mystery</a></li> <li data-toc="Perspective"><a href="#Perspective">Perspectives</a></li> <li data-toc="Primer"><a href="#Primer">Primers</a></li> <li data-toc="Research_Article"><a href="#Research_Article">Research Articles</a></li> <li data-toc="Short_Reports"><a href="#Short_Reports">Short Reports</a></li> <li data-toc="Methods_and_Resources"><a href="#Methods_and_Resources">Methods and Resources</a></li> <li data-toc="Meta-Research_Article"><a href="#Meta-Research_Article">Meta-Research Articles</a></li> <li data-toc="Preregistered_Research_Article"><a href="#Preregistered_Research_Article">Preregistered Research Article</a></li> <li data-toc="Update_Article"><a href="#Update_Article">Update Articles</a></li> </ul> </nav> <article> <div class="section cover"> <a id="Cover" name="Cover" toc="Cover" title="Cover"></a> <div class="header"> <h2 class="item-title lead-in">Cover</h2> <a href="/plosbiology/issue?id=10.1371/issue.pbio.v23.i01"> <h2 xmlns:plos="http://plos.org"><strong>Endocytosis of Wnt ligands from surrounding epithelial cells positions microtubule nucleation sites at dendrite branch points</strong></h2> </a> </div> <div class="detail-container"> <div class="img"> <a href="/plosbiology/article?id=10.1371/image.pbio.v23.i01"> <img src="/plosbiology/article/figure/image?size=inline&id=10.1371/image.pbio.v23.i01.g001" alt="Issue Image" data-doi="10.1371/image.pbio.v23.i01"> </a> </div> <div class="txt"><a xmlns:plos="http://plos.org" id="abstract1.p1" name="abstract1.p1" class="link-target"></a><p xmlns:plos="http://plos.org">Microtubule nucleation is important for microtubule organization in dendrites and for neuronal injury responses. The core nucleation protein, 纬Tubulin (纬Tub), is localized to dendrite branch points in Drosophila sensory neurons by Wnt receptors and scaffolding proteins on endosomes, but whether Wnt ligands are important is unknown. <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002973">Thyagarajan et al.</a> find that Wnt secretion from epithelial cells was required for 纬Tub localization to dendrite branch points. Using RNAi and mutant approaches, they showed that Wnt4 and wntD both position 纬Tub. Moreover, injury-induced increases in neuronal microtubule dynamics required Wnt secretion from epithelial cells. Overexpression of Wnts in epithelial cells increased microtubule dynamics to the same extent as axon injury indicating surrounding cells have an instructive role in neuronal nucleation. To determine how Wnt ligands concentrate microtubule nucleation at dendrite branch points, the authors tested whether endocytosis is restricted to specific regions of dendrites. Markers of clathrin-mediated endocytosis localized to puncta at branch points. Behavior of these puncta was sensitive to inhibition of endocytosis suggesting they represented endocytic sites. Overall, the authors propose that the localization of Wnt endocytic sites to dendrite branch points results in the local generation of microtubule nucleating endosomes. The image shows class I sensory neurons (purple) in the context of the Drosophila larval body wall; epidermal cells that sit above the neurons are shown in green.</p> <a xmlns:plos="http://plos.org" id="abstract1.p2" name="abstract1.p2" class="link-target"></a><p xmlns:plos="http://plos.org"><em>Image Credit: Pankajam Thyagarajan</em></p> </div> </div> </div> <div class="section"> <a id="Unsolved_Mystery" name="Unsolved_Mystery" toc="Unsolved Mystery" title="Unsolved Mystery"></a> <h2 class="item-title lead-in">Unsolved Mystery</h2> <div class="item cf"> <h3 class="item--article-title"> <a href="/plosbiology/article?id=10.1371/journal.pbio.3002977" title="Read Open Access Article"> <?xml version="1.0" encoding="UTF-8"?>Are oligodendrocytes bystanders or drivers of Parkinson鈥檚 disease pathology? </a> </h3> <p class="authors"> Jos茅 Mar铆a Salazar Campos, Lena F. Burbulla, Sarah J盲kel </p> <p class="article-info"><i>PLOS Biology</i>: <span class="article-info--date">published January 8, 2025</span> <span class="separator">|</span> <a href="https://doi.org/10.1371/journal.pbio.3002977">https://doi.org/10.1371/journal.pbio.3002977</a> </p> </div> </div> <div class="section"> <a id="Perspective" name="Perspective" toc="Perspective" title="Perspective"></a> <h2 class="item-title lead-in">Perspectives</h2> <div class="item cf"> <h3 class="item--article-title"> <a href="/plosbiology/article?id=10.1371/journal.pbio.3002988" title="Read Open Access Article"> <?xml version="1.0" encoding="UTF-8"?>Towards ensuring reproducibility of outsourced data generation </a> </h3> <p class="authors"> Daniel B. Sloan, Mark D. 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