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Laurence Tecott, MD, PhD | Aging, Metabolism and Emotion Center
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block-system"> <header> </header> <div id="node-10686" class="node node-ucsf-person clearfix" about="/people/laurence-tecott-md-phd" typeof="sioc:Item foaf:Document"> <div class="field field-name-field-person-headshot-photo field-type-image field-label-hidden"><div class="field-items"><div class="field-item even"><img typeof="foaf:Image" src="https://amecenter.ucsf.edu/sites/g/files/tkssra4571/f/styles/180x180/public/laurencetecott.png?itok=ePCbFyn2" width="180" height="180" alt="" /></div></div></div> <h1>Laurence Tecott, MD, PhD</h1> <span property="dc:title" content="Laurence Tecott, MD, PhD" class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-person-working-title field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">Professor Emeritus</div></div></div><div class="field field-name-field-person-primary-dept field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Psychiatry</div></div></div><div class="field field-name-field-person-email field-type-email field-label-hidden"><div class="field-items"><div class="field-item even"><a href="/cdn-cgi/l/email-protection#fa969b888883d48e9f99958e8eba8f99899cd49f9e8f"><span class="__cf_email__" data-cfemail="4925283b3b30673d2c2a263d3d093c2a3a2f672c2d3c">[email protected]</span></a></div></div></div><div class="field field-name-field-campus-phone field-type-text field-label-hidden"><div class="field-items"><div class="field-item even">+1 415 476-7861</div></div></div><div class="field field-name-field-person-publications-list field-type-entityreference field-label-above"><div class="field-label">Publications<span class="colon">:</span> </div><div class="field-items"><div class="field-item even"><div id="node-30301" class="node node-ucsf-publication node-teaser clearfix" about="/publications/gene-targeting-models-epilepsy-technical-and-analytical-considerations" typeof="sioc:Item foaf:Document"> <h4><a href="/publications/gene-targeting-models-epilepsy-technical-and-analytical-considerations">Gene Targeting Models of Epilepsy: Technical and Analytical Considerations.</a></h4> <span property="dc:title" content="Gene Targeting Models of Epilepsy: Technical and Analytical Considerations." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Neuropharmacology Methods in Epilepsy Research</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Laurence H. Tecott</p> </div></div></div> </div> </div> </div><div class="field-item odd"><div id="node-10451" class="node node-ucsf-publication node-teaser clearfix" about="/publications/age-related-changes-cerebellar-and-hypothalamic-function-accompany-non-microglial" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/27689748">Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits.</a></h4> <span property="dc:title" content="Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Aging</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Bonasera SJ, Arikkath J, Boska MD, Chaudoin TR, DeKorver NW, Goulding EH, Hoke TA, Mojtahedzedah V, Reyelts CD, Sajja B, Schenk AK, Tecott LH, Volden TA</p> </div></div></div> </div> </div> </div><div class="field-item even"><div id="node-10456" class="node node-ucsf-publication node-teaser clearfix" about="/publications/mice-lacking-serotonin-2c-receptors-have-increased-affective-responses-aversive-stimuli" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/26630489">Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli.</a></h4> <span property="dc:title" content="Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">PloS one</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Bonasera SJ, Schenk AK, Luxenberg EJ, Wang X, Basbaum A, Tecott LH</p> </div></div></div> </div> </div> </div><div class="field-item odd"><div id="node-10461" class="node node-ucsf-publication node-teaser clearfix" about="/publications/elucidation-behavioral-program-and-neuronal-network-encoded-dorsal-raphe-serotonergic" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/26383016">Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons.</a></h4> <span property="dc:title" content="Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Urban DJ, Zhu H, Marcinkiewcz CA, Michaelides M, Oshibuchi H, Rhea D, Aryal DK, Farrell MS, Lowery-Gionta E, Olsen RH, Wetsel WC, Kash TL, Hurd YL, Tecott LH, Roth BL</p> </div></div></div> </div> </div> </div><div class="field-item even"><div id="node-10466" class="node node-ucsf-publication node-teaser clearfix" about="/publications/gaio-coupled-receptor-signaling-restricts-pancreatic-%C3%9F-cell-expansion" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/25695968">Gai/o-coupled receptor signaling restricts pancreatic 脽-cell expansion.</a></h4> <span property="dc:title" content="Gai/o-coupled receptor signaling restricts pancreatic 脽-cell expansion." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Proceedings of the National Academy of Sciences of the United States of America</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS</p> </div></div></div> </div> </div> </div><div class="field-item odd"><div id="node-10471" class="node node-ucsf-publication node-teaser clearfix" about="/publications/axonal-control-adult-neural-stem-cell-niche" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/24561083">Axonal control of the adult neural stem cell niche.</a></h4> <span property="dc:title" content="Axonal control of the adult neural stem cell niche." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Cell stem cell</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Tong CK, Chen J, Cebri谩n-Silla A, Mirzadeh Z, Obernier K, Guinto CD, Tecott LH, Garc铆a-Verdugo JM, Kriegstein A, Alvarez-Buylla A</p> </div></div></div> </div> </div> </div><div class="field-item even"><div id="node-10476" class="node node-ucsf-publication node-teaser clearfix" about="/publications/serotonin-and-regulation-mammalian-energy-balance" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/23543912">Serotonin and the regulation of mammalian energy balance.</a></h4> <span property="dc:title" content="Serotonin and the regulation of mammalian energy balance." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Frontiers in neuroscience</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Donovan MH, Tecott LH</p> </div></div></div> </div> </div> </div><div class="field-item odd"><div id="node-10481" class="node node-ucsf-publication node-teaser clearfix" about="/publications/impact-serotonin-5-ht2c-receptors-executive-control-processes" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/23303047">Impact of serotonin (5-HT)2C receptors on executive control processes.</a></h4> <span property="dc:title" content="Impact of serotonin (5-HT)2C receptors on executive control processes." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Pennanen L, van der Hart M, Yu L, Tecott LH</p> </div></div></div> </div> </div> </div><div class="field-item even"><div id="node-10486" class="node node-ucsf-publication node-teaser clearfix" about="/publications/convergence-insulin-and-serotonin-programs-pancreatic-%C3%9F-cell" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/22013016">Convergence of the insulin and serotonin programs in the pancreatic 脽-cell.</a></h4> <span property="dc:title" content="Convergence of the insulin and serotonin programs in the pancreatic 脽-cell." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Diabetes</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS</p> </div></div></div> </div> </div> </div><div class="field-item odd"><div id="node-10491" class="node node-ucsf-publication node-teaser clearfix" about="/publications/flexible-estimating-equations-approach-mapping-function-valued-traits" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/21705752">A flexible estimating equations approach for mapping function-valued traits.</a></h4> <span property="dc:title" content="A flexible estimating equations approach for mapping function-valued traits." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Genetics</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Xiong H, Goulding EH, Carlson EJ, Tecott LH, McCulloch CE, Sen S</p> </div></div></div> </div> </div> </div><div class="field-item even"><div id="node-10496" class="node node-ucsf-publication node-teaser clearfix" about="/publications/behavioral-indices-ongoing-pain-are-largely-unchanged-male-mice-tissue-or-nerve-injury" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/21256675">Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity.</a></h4> <span property="dc:title" content="Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Pain</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Urban R, Scherrer G, Goulding EH, Tecott LH, Basbaum AI</p> </div></div></div> </div> </div> </div><div class="field-item odd"><div id="node-30306" class="node node-ucsf-publication node-teaser clearfix" about="/publications/role-5-ht2c-receptors-pathophysiology-and-treatment-depression" typeof="sioc:Item foaf:Document"> <h4><a href="/publications/role-5-ht2c-receptors-pathophysiology-and-treatment-depression">The Role of 5-HT2C Receptors in the Pathophysiology and Treatment of Depression.</a></h4> <span property="dc:title" content="The Role of 5-HT2C Receptors in the Pathophysiology and Treatment of Depression." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">5-HT2C Receptors in the Pathophysiology of CNS Disease</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Eliyahu Dremencov, Joost H. A. Folgering, Sandra Hogg, Laurence Tecott, Thomas I. F. H. Cremers</p> </div></div></div> </div> </div> </div><div class="field-item even"><div id="node-10501" class="node node-ucsf-publication node-teaser clearfix" about="/publications/precise-pattern-recombination-serotonergic-and-hypothalamic-neurons-pdx1-cre-transgenic" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/20950489">Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line.</a></h4> <span property="dc:title" content="Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Journal of biomedical science</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Honig G, Liou A, Berger M, German MS, Tecott LH</p> </div></div></div> </div> </div> </div><div class="field-item odd"><div id="node-10506" class="node node-ucsf-publication node-teaser clearfix" about="/publications/creb-mediates-brain-serotonin-regulation-bone-mass-through-its-expression-ventromedial" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/20952540">CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons.</a></h4> <span property="dc:title" content="CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Genes & development</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Oury F, Yadav VK, Wang Y, Zhou B, Liu XS, Guo XE, Tecott LH, Schutz G, Means AR, Karsenty G</p> </div></div></div> </div> </div> </div><div class="field-item even"><div id="node-10511" class="node node-ucsf-publication node-teaser clearfix" about="/publications/enhanced-food-anticipatory-activity-associated-enhanced-activation-extrahypothalamic" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/20668550">Enhanced food anticipatory activity associated with enhanced activation of extrahypothalamic neural pathways in serotonin2C receptor null mutant mice.</a></h4> <span property="dc:title" content="Enhanced food anticipatory activity associated with enhanced activation of extrahypothalamic neural pathways in serotonin2C receptor null mutant mice." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">PloS one</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Hsu JL, Yu L, Sullivan E, Bowman M, Mistlberger RE, Tecott LH</p> </div></div></div> </div> </div> </div><div class="field-item odd"><div id="node-10516" class="node node-ucsf-publication node-teaser clearfix" about="/publications/serotonin-regulates-pancreatic-beta-cell-mass-during-pregnancy" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/20581837">Serotonin regulates pancreatic beta cell mass during pregnancy.</a></h4> <span property="dc:title" content="Serotonin regulates pancreatic beta cell mass during pregnancy." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Nature medicine</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R, Miyatsuka T, Kosaka Y, Yang K, Honig G, van der Hart M, Kishimoto N, Wang J, Yagihashi S, Tecott LH, Watada H, German MS</p> </div></div></div> </div> </div> </div><div class="field-item even"><div id="node-10521" class="node node-ucsf-publication node-teaser clearfix" about="/publications/serotonin-activates-murine-alveolar-macrophages-through-5-ht2c-receptors" typeof="sioc:Item foaf:Document"> <h4><a href="http://www.ncbi.nlm.nih.gov/pubmed/20495077">Serotonin activates murine alveolar macrophages through 5-HT2C receptors.</a></h4> <span property="dc:title" content="Serotonin activates murine alveolar macrophages through 5-HT2C receptors." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">American journal of physiology. 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Chu</p> </div></div></div> </div> </div> </div><div class="field-item even"><div id="node-30331" class="node node-ucsf-publication node-teaser clearfix" about="/publications/neurobehavioral-analysis-serotonin-receptor-mutant-mice-0" typeof="sioc:Item foaf:Document"> <h4><a href="/publications/neurobehavioral-analysis-serotonin-receptor-mutant-mice-0">NEUROBEHAVIORAL ANALYSIS OF SEROTONIN RECEPTOR MUTANT MICE.</a></h4> <span property="dc:title" content="NEUROBEHAVIORAL ANALYSIS OF SEROTONIN RECEPTOR MUTANT MICE." class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> <div class="content"> <div class="field field-name-field-publication-name field-type-taxonomy-term-reference field-label-hidden"><div class="field-items"><div class="field-item even">Behavioural Pharmacology</div></div></div><div class="field field-name-field-publication-authorlist field-type-text-long field-label-hidden"><div class="field-items"><div class="field-item even"><p>L. H. Tecott, L. K. Heisler, K. Nonogaki, H. M. 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