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migration assays</title> <meta name="description" content="Search results for: cell migration assays"> <meta name="keywords" content="cell migration assays"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="cell migration assays"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 4848</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: cell migration assays</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4818</span> The Methodology of Out-Migration in Georgia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shorena%20Tsiklauri">Shorena Tsiklauri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Out-migration is an important issue for Georgia as well as since independence has loosed due to emigration one fifth of its population. During Soviet time out-migration from USSR was almost impossible and one of the most important instruments in regulating population movement within the Soviet Union was the system of compulsory residential registrations, so-called “propiska”. Since independent here was not any regulation for migration from Georgia. The majorities of Georgian migrants go abroad by tourist visa and then overstay, becoming the irregular labor migrants. The official statistics on migration published for this period was based on the administrative system of population registration, were insignificant in terms of numbers and did not represent the real scope of these migration movements. This paper discusses the data quality and methodology of migration statistics in Georgia and we are going to answer the questions: what is the real reason of increasing immigration flows according to the official numbers since 2000s? <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=data%20quality" title="data quality">data quality</a>, <a href="https://publications.waset.org/abstracts/search?q=Georgia" title=" Georgia"> Georgia</a>, <a href="https://publications.waset.org/abstracts/search?q=methodology" title=" methodology"> methodology</a>, <a href="https://publications.waset.org/abstracts/search?q=migration" title=" migration"> migration</a> </p> <a href="https://publications.waset.org/abstracts/26911/the-methodology-of-out-migration-in-georgia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/26911.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">417</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4817</span> Cytotoxicity of Nano β–Tricalcium Phosphate (β-TCP) on Human Osteoblast (hFOB1.19)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jer%20Ping%20Ooi">Jer Ping Ooi</a>, <a href="https://publications.waset.org/abstracts/search?q=Shah%20Rizal%20Bin%20Kasim"> Shah Rizal Bin Kasim</a>, <a href="https://publications.waset.org/abstracts/search?q=Nor%20Aini%20Saidin"> Nor Aini Saidin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objective of this study was to synthesize nano-sized β-tricalcium phosphate (β-TCP) powder and assess its cytotoxic effects on human osteoblast (hFOB1.19) by using four cytotoxicity assays, namely, lactose dehydrogenase (LDHe), tetrazolium hydroxide (XTT), neutral red (NR), and sulforhodamine B (SRB) assays. β-tricalcium phosphate (β-TCP) is a calcium phosphate compound commonly used as an implant material. To date, bulk-sized β-TCP is reported to be readily tolerated by the osteogenic cells and body based on in vitro, in vivo experiments and clinical studies. However, to what extent of nano-sized β-TCP will react in models as compared to bulk β-TCP is yet to be investigated. Thus, in this project, the cells were treated with nano β-TCP powder within a range of concentrations from 0 to 1000 μg/mL for 24, 48, and 72 h. The cytotoxicity tests showed that loss of cell viability ( > 50%) was high for hFOB1.19 cells in all assays. Cell cycle and apoptosis analysis of hFOB1.19 cells revealed that 50 μg/mL of the compound led to 30.5% of cells being apoptotic after 72 h of incubation, and the percentage was increased to 58.6% when the concentration was increased to 200 μg/mL. When the incubation time was increased from 24 to 72 h, the percentage of apoptotic cells increased from 17.3% to 58.6% when the hFOB1.19 were exposed with 200 μg/mL of nano β-TCP powder. Thus, both concentration and exposure duration affected the cytotoxicity effects of the nano β-TCP powder on hFOB1.19. We hypothesize that these cytotoxic effects on hFOB1.19 are related to the nano-scale size of the β-TCP. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=%CE%B2-tricalcium%20phosphate" title="β-tricalcium phosphate">β-tricalcium phosphate</a>, <a href="https://publications.waset.org/abstracts/search?q=hFOB1.19" title=" hFOB1.19"> hFOB1.19</a>, <a href="https://publications.waset.org/abstracts/search?q=adipose-derived%20mesenchymal%20stem%20cells" title=" adipose-derived mesenchymal stem cells"> adipose-derived mesenchymal stem cells</a>, <a href="https://publications.waset.org/abstracts/search?q=cytotoxicity" title=" cytotoxicity"> cytotoxicity</a> </p> <a href="https://publications.waset.org/abstracts/31013/cytotoxicity-of-nano-v-tricalcium-phosphate-v-tcp-on-human-osteoblast-hfob119" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31013.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">316</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4816</span> Microfluidic Chambers with Fluid Walls for Cell Biology</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Cristian%20Soitu">Cristian Soitu</a>, <a href="https://publications.waset.org/abstracts/search?q=Alexander%20Feuerborn"> Alexander Feuerborn</a>, <a href="https://publications.waset.org/abstracts/search?q=Cyril%20Deroy"> Cyril Deroy</a>, <a href="https://publications.waset.org/abstracts/search?q=Alfonso%20Castrejon-Pita"> Alfonso Castrejon-Pita</a>, <a href="https://publications.waset.org/abstracts/search?q=Peter%20R.%20Cook"> Peter R. Cook</a>, <a href="https://publications.waset.org/abstracts/search?q=Edmond%20J.%20Walsh"> Edmond J. Walsh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Microfluidics now stands as an academically mature technology after a quarter of a century research activities have delivered a vast array of proof of concepts for many biological workflows. However, translation to industry remains poor, with only a handful of notable exceptions – e.g. digital PCR, DNA sequencing – mainly because of biocompatibility issues, limited range of readouts supported or complex operation required. This technology exploits the domination of interfacial forces over gravitational ones at the microscale, replacing solid walls with fluid ones as building blocks for cell micro-environments. By employing only materials used by biologists for decades, the system is shown to be biocompatible, and easy to manufacture and operate. The method consists in displacing a continuous fluid layer into a pattern of isolated chambers overlaid with an immiscible liquid to prevent evaporation. The resulting fluid arrangements can be arrays of micro-chambers with rectangular footprint, which use the maximum surface area available, or structures with irregular patterns. Pliant, self-healing fluid walls confine volumes as small as 1 nl. Such fluidic structures can be reconfigured during the assays, giving the platform an unprecedented level of flexibility. Common workflows in cell biology are demonstrated – e.g. cell growth and retrieval, cloning, cryopreservation, fixation and immunolabeling, CRISPR-Cas9 gene editing, and proof-of-concept drug tests. This fluid-shaping technology is shown to have potential for high-throughput cell- and organism-based assays. The ability to make and reconfigure on-demand microfluidic circuits on standard Petri dishes should find many applications in biology, and yield more relevant phenotypic and genotypic responses when compared to standard microfluidic assays. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=fluid%20walls" title="fluid walls">fluid walls</a>, <a href="https://publications.waset.org/abstracts/search?q=micro-chambers" title=" micro-chambers"> micro-chambers</a>, <a href="https://publications.waset.org/abstracts/search?q=reconfigurable" title=" reconfigurable"> reconfigurable</a>, <a href="https://publications.waset.org/abstracts/search?q=freestyle" title=" freestyle"> freestyle</a> </p> <a href="https://publications.waset.org/abstracts/100339/microfluidic-chambers-with-fluid-walls-for-cell-biology" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/100339.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">193</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4815</span> The Socio-Economic Consequences of Educational Migration for Georgia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Eteri%20Kharaishvili">Eteri Kharaishvili</a>, <a href="https://publications.waset.org/abstracts/search?q=Marina%20%20Chavleishvili"> Marina Chavleishvili</a>, <a href="https://publications.waset.org/abstracts/search?q=Manana%20Lobzhanidze"> Manana Lobzhanidze</a>, <a href="https://publications.waset.org/abstracts/search?q=Nino%20Grigolia"> Nino Grigolia</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The article analyzes Georgia's involvement in global migration processes, assessing migration research and policy regulatory documents. The socio-economic situation of young people has been studied in the paper, their employment and unemployment levels are analyzed, reasons for migration of youth are revealed, the impact of migration on the socio-economic development of the country is substantiated. Youth demand on education is also assessed, problems in the education sector are identified, educational migration indicators are analyzed according to the internationalization process of this sector. Based on the analysis of the motivations of young people in Georgia, orientation of values and the aspects conditioning life strategies the factors affecting educational migration are determined and the results of the positive and negative impact of educational migration on the socio-economic development of the country are substantiated. The importance of efficient management of educational migration for Georgia in getting closer to the EU and achieving inclusive economic grow this substantiated. Recommendations for efficient management of the process of Georgian citizens’ learning and acquiring experience, as well as the internationalization of education sector and educational migration, are drawn. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=educational%20migration" title="educational migration">educational migration</a>, <a href="https://publications.waset.org/abstracts/search?q=migration%20management" title=" migration management"> migration management</a>, <a href="https://publications.waset.org/abstracts/search?q=migration%20of%20youth" title=" migration of youth"> migration of youth</a>, <a href="https://publications.waset.org/abstracts/search?q=socio-economic%20results%20of%20educational%20migration" title=" socio-economic results of educational migration"> socio-economic results of educational migration</a>, <a href="https://publications.waset.org/abstracts/search?q=youth%20employment" title=" youth employment"> youth employment</a> </p> <a href="https://publications.waset.org/abstracts/94606/the-socio-economic-consequences-of-educational-migration-for-georgia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/94606.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">255</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4814</span> The Return Migration as One of the Possibilities of Migrant Mobility after the Financial Crisis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sabrina%20Mortet">Sabrina Mortet</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The economic crisis, which struck the world economy in mid-2008, had an impact on migration in Europe, especially the employment situation of migrant workers. That’s why migrants tended to be the first to lose their jobs during the crisis, victims of the rule "last–in, first-out”. In the same context, the economic recession which affected the migration flows, immigration level has slowed while emigration has increased in some European countries. Since people go where jobs are, we will try to speak about the mobility of migrants after the crisis by focusing on return migration to see if migrants in the period of recession prefer going home or staying in the host country; and we will take Spain as a case of study, because it had attracted an extraordinarily high inflows of migration and it is one of the EU country which was hardly affected by the financial crisis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=economic%20crisis" title="economic crisis">economic crisis</a>, <a href="https://publications.waset.org/abstracts/search?q=international%20migration" title=" international migration"> international migration</a>, <a href="https://publications.waset.org/abstracts/search?q=mobility" title=" mobility"> mobility</a>, <a href="https://publications.waset.org/abstracts/search?q=return%20migration" title=" return migration"> return migration</a>, <a href="https://publications.waset.org/abstracts/search?q=employement" title=" employement"> employement</a> </p> <a href="https://publications.waset.org/abstracts/48688/the-return-migration-as-one-of-the-possibilities-of-migrant-mobility-after-the-financial-crisis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/48688.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">330</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4813</span> Assessment of Platelet and Lymphocyte Interaction in Autoimmune Hyperthyroidism</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ma%C5%82gorzata%20Tomczy%C5%84ska">Małgorzata Tomczyńska</a>, <a href="https://publications.waset.org/abstracts/search?q=Joanna%20Saluk-Bijak"> Joanna Saluk-Bijak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Graves’ disease is a frequent organ-specific autoimmune thyroid disease, which characterized by the presence of different kind autoantibodies, that, in most cases, act as agonists of the thyrotropin receptor, leading to hyperthyroidism. Role of platelets and lymphocytes can be modulated in the pathophysiology of thyroid autoimmune diseases. Interference in the physiology of platelets can lead to enhanced activity of these cells. Activated platelets can bind to circulating lymphocytes and to affect lymphocyte adhesion. Platelets and lymphocytes can regulate mutual functions. Therefore, the activation of T lymphocytes, as well as blood platelets, is associated with the development of inflammation and oxidative stress within the target tissue. The present study was performed to investigate a platelet-lymphocyte relation by assessing the degree of their mutual aggregation in whole blood of patients with Graves’ disease. Also, the purpose of this study was to examine the impact of platelet interaction on lymphocyte migration capacity. Methods: 30 patients with Graves’ disease were recruited in the study. The matched 30 healthy subjects were served as the control group. Immunophenotyping of lymphocytes was carried out by flow cytometry method. A CytoSelect™ Cell Migration Assay Kit was used to evaluate lymphocyte migration and adhesion to blood platelets. Visual assessment of lymphocyte-platelet aggregate morphology was done using confocal microscope after magnetic cell isolation by Miltenyi Biotec. Results: The migration and functional responses of lymphocytes to blood platelets were greater in the group of Graves’ disease patients compared with healthy controls. The group of Graves’ disease patients exhibited a reduced T lymphocyte and a higher B cell count compared with controls. Based on microscopic analysis, more platelet-lymphocyte aggregates were found in patients than in control. Conclusions: Studies have shown that in Graves' disease, lymphocytes show increased platelet affinity, more strongly migrating toward them, and forming mutual cellular conglomerates. This may be due to the increased activation of blood platelets in this disease. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=blood%20platelets" title="blood platelets">blood platelets</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20migration" title=" cell migration"> cell migration</a>, <a href="https://publications.waset.org/abstracts/search?q=Graves%E2%80%99%20disease" title=" Graves’ disease"> Graves’ disease</a>, <a href="https://publications.waset.org/abstracts/search?q=lymphocytes" title=" lymphocytes"> lymphocytes</a>, <a href="https://publications.waset.org/abstracts/search?q=lymphocyte-platelet%20aggregates" title=" lymphocyte-platelet aggregates"> lymphocyte-platelet aggregates</a> </p> <a href="https://publications.waset.org/abstracts/78333/assessment-of-platelet-and-lymphocyte-interaction-in-autoimmune-hyperthyroidism" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/78333.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">227</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4812</span> Socio-Demographic, Cause, and Benefit of Internal and International Migration: A Case Study of Mazar-i-Sharif, Balkh Province, Afghanistan</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Baqir%20Khawari">Baqir Khawari</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Migration has a long history in Afghanistan even before, but it has been exacerbated in the last decade. Using actual household data of 1060 in Mazar-i-Sharif, the capital of Balkh province, obtained from a strictly random process, the study examined to evaluate the main causes and benefits of the migration. It is found that the main reasons for internal migration are unemployment and income inequality, in addition to war and poverty as international parameters for migration. Furthermore, the study demonstrated that households receive benefits from their migrants through remittances to increase their income and smooth consumption. Thus, the study suggests that to manage migration in Afghanistan, the government and international organizations should work together for peace and reduction of poverty in Afghanistan otherwise, the crisis of migration will continue in the future as well. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=migration" title="migration">migration</a>, <a href="https://publications.waset.org/abstracts/search?q=remittances" title=" remittances"> remittances</a>, <a href="https://publications.waset.org/abstracts/search?q=socio-demographic" title=" socio-demographic"> socio-demographic</a>, <a href="https://publications.waset.org/abstracts/search?q=household" title=" household"> household</a>, <a href="https://publications.waset.org/abstracts/search?q=Afghanistan" title=" Afghanistan"> Afghanistan</a> </p> <a href="https://publications.waset.org/abstracts/177081/socio-demographic-cause-and-benefit-of-internal-and-international-migration-a-case-study-of-mazar-i-sharif-balkh-province-afghanistan" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/177081.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">74</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4811</span> Circular Labour Migration and Its Consequences in Georgia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Manana%20Lobzhanidze">Manana Lobzhanidze</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: The paper will argue that labor migration is the most important problem Georgia faces today. The structure of labor migration by age and gender of Georgia is analyzed. The main driving factors of circular labor migration during the last ten years are identified. While studying migration, it is necessary to discuss the interconnection of economic, social, and demographic features, also taking into consideration the policy of state regulations in terms of education and professional training. Methodology: Different research methods are applied in the presented paper: statistical, such as selection, grouping, observation, trend, and qualitative research methods, namely; analysis, synthesis, induction, deduction, comparison ones. Main Findings: Labour migrants are filling the labor market as a low salary worker. The main positive feedback of migration from developing countries is poverty eradication, but this process is accompanied by problems, such as 'Brain Drain'. The country loses an important part of its intellectual potential, and it is invested by households or state itself. Conclusions: Labor migration is characterized to be temporary, but socio-economic problems of the country often push the labor migration in the direction of longterm and illegal migration. Countries with developed economies try to stricter migration policy and fight illegal migration with different methods; circular migration helps solve this problem. Conclusions and recommendations are included about circular labor migration consequences in Georgia and its influence on the reduction of unemployment level. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=migration" title="migration">migration</a>, <a href="https://publications.waset.org/abstracts/search?q=circular%20labor%20migration" title=" circular labor migration"> circular labor migration</a>, <a href="https://publications.waset.org/abstracts/search?q=labor%20migration%20employment" title=" labor migration employment"> labor migration employment</a>, <a href="https://publications.waset.org/abstracts/search?q=unemployment" title=" unemployment"> unemployment</a> </p> <a href="https://publications.waset.org/abstracts/124359/circular-labour-migration-and-its-consequences-in-georgia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/124359.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">179</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4810</span> In vitro Antioxidant Activity of Caesalpinia sappan Extract</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Monthon%20Tangjitmungman">Monthon Tangjitmungman</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Numerous diseases have been linked to oxidative stress, in which a disproportion of free radicals in the body leads to tissue or cell damage. Polyphenols are the most abundant antioxidants found in plants, and they are highly effective at scavenging oxidative free radicals. Due to the presence of phenolic compounds in Caesalpinia sappan has been discovered to have antioxidant activity. It has several health benefits, the most important of which is preventing cardiovascular and cancer diseases. This study aimed to determine the phenolic content and antioxidant activity of C. sappan extract using a variety of antioxidant assays. The extract of C. sappan was made using a mixture of solvents (ethyl alcohol: water in ratio 8:2). The total phenolic content of C. sappan extract was determined and expressed as gallic acid equivalents using the Folin-Cioucalteu method (GAE). The antioxidant activity of C. sappan extract was assessed using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay and the ABTS radical scavenging capacity assay. An association was found between antioxidant activity and total phenol content. The antioxidant activity of C. sappan extract was also determined by DPPH and ABTS assays. The IC50 values for C. sappan extract from DPPH and ABTS assays were 54.48 μg/mL ± 0.545 and 25.46 μg/mL ± 0.790, respectively, in the DPPH assay. In the DPPH assay, vitamin C was used as a positive control, whereas Trolox was used as a positive control in the ABTS assay. In conclusion, C. sappan extract contains a high level of total phenolics and exhibits significant antioxidant activity. Nevertheless, more research should be done on the antioxidant activity, such as SOD and ROS scavenging assays and in vivo experiments, to determine whether the compound has antioxidant activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ABTS%20assay" title="ABTS assay">ABTS assay</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title=" antioxidant activity"> antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=Caesalpinia%20sappan" title=" Caesalpinia sappan"> Caesalpinia sappan</a>, <a href="https://publications.waset.org/abstracts/search?q=DPPH%20assays" title=" DPPH assays"> DPPH assays</a>, <a href="https://publications.waset.org/abstracts/search?q=total%20phenolic%20content" title=" total phenolic content"> total phenolic content</a> </p> <a href="https://publications.waset.org/abstracts/140865/in-vitro-antioxidant-activity-of-caesalpinia-sappan-extract" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/140865.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">384</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4809</span> Investigating the Rate of Migration of Plasticizers from PET Bottles into Salad Oil during Storage</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Simin%20Asadollahi">Simin Asadollahi</a>, <a href="https://publications.waset.org/abstracts/search?q=Amir%20H.%20Soruri"> Amir H. Soruri</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Moghimi"> Ali Moghimi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nowadays, salad oils are used in many countries around the world. Therefore, it is of great importance to ensure the safety of these food products which are usually packaged in Polyethylene terephthalate (PET) bottles and come on the market. This study investigated the effects of storage time and temperature on the migration rate of phthalate compounds from PET bottle to salad oil. In more detail, migration rate of bis (2-ethylhexyl) phthalate from bottles to salad oil samples was measured in 1st, the 30th, and the 60th days of storage at a temperature of either 20 or 40 °C. At both storage temperatures, an increase in the storage time led to a statistically significant increase in the migration rate of phthalate compounds (p<.01). Regarding this, the highest migration rate occurred after 60 days of storage in to the samples. Furthermore, it was revealed bis (2-ethylhexyl) phthalate had a higher migration rate at 40 °C than at 20 °C which showed that an increase in the storage temperature would lead to an increase in the migration rate. The highest migration rate occurred in relation to salad oil stored at 40 °C and after 60 days of storage. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=salad%20oil" title="salad oil">salad oil</a>, <a href="https://publications.waset.org/abstracts/search?q=migration%20rate" title=" migration rate"> migration rate</a>, <a href="https://publications.waset.org/abstracts/search?q=polyethylene%20terephthalate" title=" polyethylene terephthalate"> polyethylene terephthalate</a>, <a href="https://publications.waset.org/abstracts/search?q=bis%20%282-ethylhexyl%29%20phthalate" title=" bis (2-ethylhexyl) phthalate"> bis (2-ethylhexyl) phthalate</a> </p> <a href="https://publications.waset.org/abstracts/34909/investigating-the-rate-of-migration-of-plasticizers-from-pet-bottles-into-salad-oil-during-storage" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/34909.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">365</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4808</span> A Dirty Page Migration Method in Process of Memory Migration Based on Pre-copy Technology</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kang%20Zijian">Kang Zijian</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhang%20Tingyu"> Zhang Tingyu</a>, <a href="https://publications.waset.org/abstracts/search?q=Burra%20Venkata%20Durga%20Kumar"> Burra Venkata Durga Kumar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This article investigates the challenges in memory migration during the live migration of virtual machines. We found three challenges probably existing in pre-copy technology. One of the main challenges is the challenge of downtime migration. Decrease the downtime could promise the normal work for a virtual machine. Although pre-copy technology is greatly decreasing the downtime, we still need to shut down the machine in order to finish the last round of data transfer. This paper provides an optimization scheme for the problems existing in pro-copy technology, mainly the optimization of the dirty page migration mechanism. The typical pre-copy technology copy n-1th’s dirty pages in nth turn. However, our idea is to create a double iteration method to solve this problem. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=virtual%20machine" title="virtual machine">virtual machine</a>, <a href="https://publications.waset.org/abstracts/search?q=pre-copy%20technology" title=" pre-copy technology"> pre-copy technology</a>, <a href="https://publications.waset.org/abstracts/search?q=memory%20migration%20process" title=" memory migration process"> memory migration process</a>, <a href="https://publications.waset.org/abstracts/search?q=downtime" title=" downtime"> downtime</a>, <a href="https://publications.waset.org/abstracts/search?q=dirty%20pages%20migration%20method" title=" dirty pages migration method"> dirty pages migration method</a> </p> <a href="https://publications.waset.org/abstracts/169033/a-dirty-page-migration-method-in-process-of-memory-migration-based-on-pre-copy-technology" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/169033.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">151</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4807</span> Angiomotin Regulates Integrin Beta 1-Mediated Endothelial Cell Migration and Angiogenesis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yuanyuan%20Zhang">Yuanyuan Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Yujuan%20Zheng"> Yujuan Zheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Giuseppina%20Barutello"> Giuseppina Barutello</a>, <a href="https://publications.waset.org/abstracts/search?q=Sumako%20Kameishi"> Sumako Kameishi</a>, <a href="https://publications.waset.org/abstracts/search?q=Kungchun%20Chiu"> Kungchun Chiu</a>, <a href="https://publications.waset.org/abstracts/search?q=Katharina%20Hennig"> Katharina Hennig</a>, <a href="https://publications.waset.org/abstracts/search?q=Martial%20Balland"> Martial Balland</a>, <a href="https://publications.waset.org/abstracts/search?q=Federica%20Cavallo"> Federica Cavallo</a>, <a href="https://publications.waset.org/abstracts/search?q=Lars%20Holmgren"> Lars Holmgren</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Angiogenesis describes that new blood vessels migrate from pre-existing ones to form 3D lumenized structure and remodeling. During directional migration toward the gradient of pro-angiogenic factors, the endothelial cells, especially the tip cells need filopodia to sense the environment and exert the pulling force. Of particular interest are the integrin proteins, which play an essential role in focal adhesion in the connection between migrating cells and extracellular matrix (ECM). Understanding how these biomechanical complexes orchestrate intrinsic and extrinsic forces is important for our understanding of the underlying mechanisms driving angiogenesis. We have previously identified Angiomotin (Amot), a member of Amot scaffold protein family, as a promoter for endothelial cell migration in vitro and zebrafish models. Hence, we established inducible endothelial-specific Amot knock-out mice to study normal retinal angiogenesis as well as tumor angiogenesis. We found that the migration ratio of the blood vessel network to the edge was significantly decreased in Amotec- retinas at postnatal day 6 (P6). While almost all the Amot defect tip cells lost migration advantages at P7. In consistence with the dramatic morphology defect of tip cells, there was a non-autonomous defect in astrocytes, as well as the disorganized fibronectin expression pattern correspondingly in migration front. Furthermore, the growth of transplanted LLC tumor was inhibited in Amot knockout mice due to fewer vasculature involved. By using MMTV-PyMT transgenic mouse model, there was a significantly longer period before tumors arised when Amot was specifically knocked out in blood vessels. In vitro evidence showed that Amot binded to beta-actin, Integrin beta 1 (ITGB1), Fibronectin, FAK, Vinculin, major focal adhesion molecules, and ITGB1 and stress fibers were distinctly induced by Amot transfection. Via traction force microscopy, the total energy (force indicater) was found significantly decreased in Amot knockdown cells. Taken together, we propose that Amot is a novel partner of the ITGB1/Fibronectin protein complex at focal adhesion and required for exerting force transition between endothelial cell and extracellular matrix. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=angiogenesis" title="angiogenesis">angiogenesis</a>, <a href="https://publications.waset.org/abstracts/search?q=angiomotin" title=" angiomotin"> angiomotin</a>, <a href="https://publications.waset.org/abstracts/search?q=endothelial%20cell%20migration" title=" endothelial cell migration"> endothelial cell migration</a>, <a href="https://publications.waset.org/abstracts/search?q=focal%20adhesion" title=" focal adhesion"> focal adhesion</a>, <a href="https://publications.waset.org/abstracts/search?q=integrin%20beta%201" title=" integrin beta 1"> integrin beta 1</a> </p> <a href="https://publications.waset.org/abstracts/72725/angiomotin-regulates-integrin-beta-1-mediated-endothelial-cell-migration-and-angiogenesis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/72725.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">237</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4806</span> Labour Migration in Russia in the Context of Russia’s National Security Problem</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20V.%20Dolzhikova">A. V. Dolzhikova</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The article deals with the problems of labour migration in the Russian Federation in the context of Russia's national security, provides the typology of migrants residing in the territory of the Russian Federation and analyzes the risk factors. The author considers the structure of migration flows and the terms of legal, economic and socio-cultural adaptation of migrants in the Russian Federation. In this connection, the status of the Russian migration legislation, the concept of the comprehensive exam in Russian as a foreign language, history of Russia and the basics of the Russian Federation legislation for foreign citizens which was introduced in Russia on January 1, 2015, are analyzed. The article discloses its role as the adaptation strategy and the factor of Russia's migration security. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=comprehensive%20exam" title="comprehensive exam">comprehensive exam</a>, <a href="https://publications.waset.org/abstracts/search?q=migration%20policy" title=" migration policy"> migration policy</a>, <a href="https://publications.waset.org/abstracts/search?q=migration%20legislation" title=" migration legislation"> migration legislation</a>, <a href="https://publications.waset.org/abstracts/search?q=Russia%27s%20national%20security" title=" Russia's national security"> Russia's national security</a> </p> <a href="https://publications.waset.org/abstracts/49836/labour-migration-in-russia-in-the-context-of-russias-national-security-problem" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/49836.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">365</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4805</span> Homing of B Cells via Afferent Lymphatics</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sara%20Pereira-Nogueira">Sara Pereira-Nogueira</a>, <a href="https://publications.waset.org/abstracts/search?q=Tim%20Worbs"> Tim Worbs</a>, <a href="https://publications.waset.org/abstracts/search?q=Marc%20Permanyer-Bosser"> Marc Permanyer-Bosser</a>, <a href="https://publications.waset.org/abstracts/search?q=Reinhold%20F%C3%B6rster"> Reinhold Förster</a> </p> <p class="card-text"><strong>Abstract:</strong></p> While the entry mechanism of lymphocytes into the lymph node via the blood are well described, it is still largely unknown how cells enter lymph nodes that arrive via afferent lymphatics. In order to address this, our group has established a micro-injection technique in mice through which cells are delivered directly into the lymphatic vessel immediately afferent to the popliteal lymph node. Injected cells can then be tracked via multi-colour fluorescence or 2-photon microscopy, and their localization can be analysed within the popliteal or downstream lymph nodes by immunohistology. Since naïve B cells express the chemokine receptor CXCR5 we intra-lymphatically co-injected B cells derived from wildtype and Cxcr5-deficient mice. While CXCR5 does not play a role in guiding B cells out of the subcapsular sinus, it affects their positioning within the lymph node parenchyma, since CXCR5-deficient B cells are impaired in migrating into the B cell follicle. The knowledge obtained by studying B-cell migration may prove beneficial in clinical settings regarding tumor metastasis or autoimmune diseases. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=afferent%20lymphatics" title="afferent lymphatics">afferent lymphatics</a>, <a href="https://publications.waset.org/abstracts/search?q=B%20cell%20migration" title=" B cell migration"> B cell migration</a>, <a href="https://publications.waset.org/abstracts/search?q=chemokine" title=" chemokine"> chemokine</a>, <a href="https://publications.waset.org/abstracts/search?q=intra-lymphatic%20injection" title=" intra-lymphatic injection"> intra-lymphatic injection</a> </p> <a href="https://publications.waset.org/abstracts/75819/homing-of-b-cells-via-afferent-lymphatics" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75819.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">263</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4804</span> Establishment and Characterization of a Dentigerous Cyst Cell Line</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mu%C3%B1iz-Lino%20Marcos%20Agust%C3%ADn">Muñiz-Lino Marcos Agustín</a>, <a href="https://publications.waset.org/abstracts/search?q=Vazquez%20Borbolla%20Jessica"> Vazquez Borbolla Jessica</a>, <a href="https://publications.waset.org/abstracts/search?q=Lic%C3%A9aga-Escalera%20Carlos"> Licéaga-Escalera Carlos</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The ectomesenchymal tissues involved in tooth development and their remnants are the origin of different odontogenic lesions, including tumors and cysts of the jaws, with a wide range of clinical behaviors. Dentigerous cyst (DC) represents approximately 20% of all cases of odontogenic cysts, and it has been demonstrated that it can develop benign and malignant odontogenic tumors. DC is characterized by bone destruction of the area surrounding the crown of a tooth which has not erupted and it contain is liquid. The treatment of odontogenic tumors and cysts usually are partial or total removal of the jaw, causing important secondary co-morbidities. However, molecules implicated in DC pathogenesis as well in its development to odontogenic tumors remains unknown. A cellular model may be useful to study these molecules, but that model has not been established yet. Here, we reported the establishment of a cell culture derived from a dentigerous cyst. This cell line was named DeCy-1. In spite of its ectomesenchymal morphology, DeCy-1 cells express epithelial markers such as cytokeratins 5, 6, and 8. Furthermore, these cells express the ODAM protein, which is present in odontogenesis and in dental follicle, indicating that DeCy-1 cells derived from odontogenic epithelium. Analysis by electron microscopy of this cell line showed that it has a high vesicular activity, suggesting that DeCy-1 could secrete molecules that may be involved in DC pathogenesis. Thus, secreted proteins were analyzed by PAGE-SDS, where we observed approximately 11 bands. In addition, the capacity of these secretions to degrade proteins was analyzed by gelatin substrate zymography. A degradation band of about 62 kDa was found in these assays. Western blot assays suggested that the matrix metalloproteinase 2 (MMP-2) is responsible of this protease activity. Thus, our results indicate that the establishment of a cell line derived from DC is a useful in vitro model to study the biology of this odontogenic lesion and its participation in the development of odontogenic tumors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dentigerous%20cyst" title="dentigerous cyst">dentigerous cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=MMP20" title=" MMP20"> MMP20</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer" title=" cancer"> cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20culture" title=" cell culture"> cell culture</a> </p> <a href="https://publications.waset.org/abstracts/149311/establishment-and-characterization-of-a-dentigerous-cyst-cell-line" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/149311.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">135</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4803</span> DAG Design and Tradeoff for Full Live Virtual Machine Migration over XIA Network</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dalu%20Zhang">Dalu Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Xiang%20Jin"> Xiang Jin</a>, <a href="https://publications.waset.org/abstracts/search?q=Dejiang%20Zhou"> Dejiang Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianpeng%20Wang"> Jianpeng Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Haiying%20Jiang"> Haiying Jiang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Traditional TCP/IP network is showing lots of shortages and research for future networks is becoming a hotspot. FIA (Future Internet Architecture) and FIA-NP (Next Phase) are supported by US NSF for future Internet designing. Moreover, virtual machine migration is a significant technique in cloud computing. As a network application, it should also be supported in XIA (expressive Internet Architecture), which is in both FIA and FIA-NP projects. This paper is an experimental study aims at verifying the feasibility of VM migration over XIA. We present three ways to maintain VM connectivity and communication states concerning DAG design and routing table modification. VM migration experiments are conducted intra-AD and inter-AD with KVM instances. The procedure is achieved by a migration control protocol which is suitable for the characters of XIA. Evaluation results show that our solutions can well supports full live VM migration over XIA network respectively, keeping services seamless. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=DAG" title="DAG">DAG</a>, <a href="https://publications.waset.org/abstracts/search?q=downtime" title=" downtime"> downtime</a>, <a href="https://publications.waset.org/abstracts/search?q=virtual%20machine%20migration" title=" virtual machine migration"> virtual machine migration</a>, <a href="https://publications.waset.org/abstracts/search?q=XIA" title=" XIA"> XIA</a> </p> <a href="https://publications.waset.org/abstracts/13535/dag-design-and-tradeoff-for-full-live-virtual-machine-migration-over-xia-network" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13535.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">855</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4802</span> Sri Lanka-Middle East Labour Migration Corridor: Trends, Patterns and Structural Changes </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dinesha%20Siriwardhane">Dinesha Siriwardhane</a>, <a href="https://publications.waset.org/abstracts/search?q=Indralal%20De%20Silva"> Indralal De Silva</a>, <a href="https://publications.waset.org/abstracts/search?q=Sampath%20Amaratunge"> Sampath Amaratunge</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective of this study is to explore the recent trends, patterns and the structural changes in the labour migration from Sri Lanka to Middle East countries and to discuss the possible impacts of those changes on the remittance flow. Study uses secondary data published by Sri Lanka Bureau of Foreign Employment and Central Bank. Thematic analysis of the secondary data revealed that the migration for labour has increased rapidly during past decades. Parallel with that the gender and the skill composition of the migration flow has been changing. Similarly, the destinations for male migration have changed over the period. These show positive implications on the international remittance receipts to the country. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=migration" title="migration">migration</a>, <a href="https://publications.waset.org/abstracts/search?q=middle%20east" title=" middle east"> middle east</a>, <a href="https://publications.waset.org/abstracts/search?q=Sri%20Lanka" title=" Sri Lanka"> Sri Lanka</a>, <a href="https://publications.waset.org/abstracts/search?q=social%20sciences" title=" social sciences"> social sciences</a> </p> <a href="https://publications.waset.org/abstracts/20557/sri-lanka-middle-east-labour-migration-corridor-trends-patterns-and-structural-changes" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20557.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">399</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4801</span> Patterns, Determinants, and Implications of Rural-Urban Migration in the Garhwal Himalaya</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Saurav%20Kumar">Saurav Kumar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Rural-urban migration is the most commonly adopted strategy in rural areas to overcome the risk associated with the subsistence economy and diversify income. The Garhwal Himalaya has the highest rate of rural-urban migration in India, which has serious repercussions. Despite this, there is a dearth of literature on the implications of rural-urban migration in the Garhwal Himalaya. This paper attempts to fill this void. The objectives of the paper are to look into various types, patterns, determinants, and implications of rural-urban migration in the Garhwal Himalaya. In order to meet the objectives, 15 villages were selected from five districts of the Garhwal Himalaya. In every district, three villages were chosen from different altitudes, including five from river valleys, five from mid-altitudes, and five from highlands. The villages range in altitude from 550m to 2660m. A total of 658 households were surveyed from the villages, covering 100% samples from each village. Using a structured questionnaire, the author asked the heads of each household about the types of rural-urban migration they practiced, the year of first migration, destinations of migration, and reasons for migration. Further, migrants’ age, sex, caste, marital status, educational background, income, occupation, and remittances sent by migrants were also inquired about. The study reveals that rural-urban migration is a serious problem in Garhwal Himalayas, posing various socio-economic issues. Without immediate action, it will have serious consequences. Finally, this study suggests some policy measures to minimize the current rate of rural-urban migration in the Garhwal Himalaya. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=rural-urban%20migration" title="rural-urban migration">rural-urban migration</a>, <a href="https://publications.waset.org/abstracts/search?q=Garhwal%20Himalaya" title=" Garhwal Himalaya"> Garhwal Himalaya</a>, <a href="https://publications.waset.org/abstracts/search?q=patterns" title=" patterns"> patterns</a>, <a href="https://publications.waset.org/abstracts/search?q=determinants" title=" determinants"> determinants</a>, <a href="https://publications.waset.org/abstracts/search?q=implications" title=" implications"> implications</a> </p> <a href="https://publications.waset.org/abstracts/154891/patterns-determinants-and-implications-of-rural-urban-migration-in-the-garhwal-himalaya" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/154891.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">129</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4800</span> Characterization of a Dentigerous Cyst Cell Line and Its Secretion of Metalloproteinases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mu%C3%B1iz-Lino%20Marcos%20A.">Muñiz-Lino Marcos A.</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The ectomesenchymal tissues involved in tooth development and their remnants are the origin of different odontogenic lesions, including tumors and cysts of the jaws, with a wide range of clinical behaviors. A dentigerous cyst (DC) represents approximately 20% of all cases of odontogenic cysts, and it has been demonstrated that it can develop benign and malignant odontogenic tumors. DC is characterized by bone destruction of the area surrounding the crown of a tooth that has not erupted and contains liquid. The treatment of odontogenic tumors and cysts usually involves a partial or total removal of the jaw, causing important secondary co-morbidities. However, molecules implicated in DC pathogenesis, as well as in its development into odontogenic tumors, remain unknown. A cellular model may be useful to study these molecules, but that model has not been established yet. Here, we reported the establishment of a cell culture derived from a dentigerous cyst. This cell line was named DeCy-1. In spite of its ectomesenchymal morphology, DeCy-1 cells express epithelial markers such as cytokeratins 5, 6, and 8. Furthermore, these cells express the ODAM protein, which is present in odontogenesis and in dental follicles, indicating that DeCy-1 cells are derived from odontogenic epithelium. Analysis by electron microscopy of this cell line showed that it has a high vesicular activity, suggesting that DeCy-1 could secrete molecules that may be involved in DC pathogenesis. Thus, secreted proteins were analyzed by PAGE-SDS where we observed approximately 11 bands. In addition, the capacity of these secretions to degrade proteins was analyzed by gelatin substrate zymography. A degradation band of about 62 kDa was found in these assays. Western blot assays suggested that the matrix metalloproteinase 2 (MMP-2) is responsible for this protease activity. Thus, our results indicate that the establishment of a cell line derived from DC is a useful in vitro model to study the biology of this odontogenic lesion and its participation in the development of odontogenic tumors. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dentigerous%20cyst" title="dentigerous cyst">dentigerous cyst</a>, <a href="https://publications.waset.org/abstracts/search?q=ameloblastoma" title=" ameloblastoma"> ameloblastoma</a>, <a href="https://publications.waset.org/abstracts/search?q=MMP-2" title=" MMP-2"> MMP-2</a>, <a href="https://publications.waset.org/abstracts/search?q=odontogenic%20tumors" title=" odontogenic tumors"> odontogenic tumors</a> </p> <a href="https://publications.waset.org/abstracts/188383/characterization-of-a-dentigerous-cyst-cell-line-and-its-secretion-of-metalloproteinases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/188383.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">40</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4799</span> Cratoxy Formosum (Jack) Dyer Leaf Extract-Induced Human Breast and Liver Cancer Cells Death</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Benjaporn%20Buranrat">Benjaporn Buranrat</a>, <a href="https://publications.waset.org/abstracts/search?q=Nootchanat%20Mairuae"> Nootchanat Mairuae</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cratoxylum formosum (Jack) Dyer (CF) has been used for the traditional medicines in South East Asian and Thailand. Normally, northeast Thai vegetables have proven cytotoxic to many cancer cells. Therefore, the present study aims to explore the molecular mechanisms underlying CF-induced cancer cell death and apoptosis on breast and liver cancer cells. The cytotoxicity and antiproliferative effects of CF on the human breast MCF-7 and liver HepG2 cancer cell lines were evaluated using sulforhodamine B assay and colony formation assay. Cell migration assay was measured using wound healing assay. The apoptosis induction mechanisms were investigated through reactive oxygen species formation, caspase 3 activity, and JC-1 activity. Gene expression by real-time PCR and apoptosis related protein levels by Western blot analysis. CF induced MCF-7 and HepG2 cell death by time- and dose-dependent manner. Furthermore, CF had the greater cytotoxic potency on MCF-7 more than HepG2 cells with IC50 values of 85.70+4.52 μM and 219.03±9.96 μM respectively, at 24 h. Treatment with CF also caused a dose-dependent decrease in colony forming ability and cell migration, especially on MCF-7 cells. CF induced ROS formation, increased caspase 3 activities, and decreased the mitochondrial membrane potential, and causing apoptotic body production and DNA fragmentation. CF significantly decreased expression of the cell cycle regulatory protein RAC1 and downstream proteins, cdk6. Additionally, CF enhanced p21 and reduced cyclin D1 protein levels. CF leaf extract induced cell death, apoptosis, antimigration in both of MCF-7 and HepG2 cells. CF could be useful for developing to anticancer drug candidate for breast and liver cancer therapy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cratoxylum%20formosum%20%28jack%29%20dyer" title="cratoxylum formosum (jack) dyer">cratoxylum formosum (jack) dyer</a>, <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title=" breast cancer"> breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=liver%20cancer" title=" liver cancer"> liver cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20death" title=" cell death"> cell death</a> </p> <a href="https://publications.waset.org/abstracts/52780/cratoxy-formosum-jack-dyer-leaf-extract-induced-human-breast-and-liver-cancer-cells-death" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52780.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">211</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4798</span> The Inhibitory Effect of Weissella koreensis 521 Isolated from Kimchi on 3T3-L1 Adipocyte Differentiation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kyungbae%20Pi">Kyungbae Pi</a>, <a href="https://publications.waset.org/abstracts/search?q=Kibeom%20Lee"> Kibeom Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Yongil%20Kim"> Yongil Kim</a>, <a href="https://publications.waset.org/abstracts/search?q=Eun-Jung%20Lee"> Eun-Jung Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Abnormal adipocyte growth, in terms of increased cell numbers and increased cell differentiation, is considered to be a major pathological feature of obesity. Thus, the inhibition of preadipocyte mitogenesis and differentiation could help prevent and suppress obesity. The aim of this study was to assess whether extracts from Weissella koreensis 521 cells isolated from kimchi could exert anti-adipogenic effects in 3T3-L1 cells (fat cells). Differentiating 3T3-L1 cells were treated with W. koreensis 521 cell extracts (W. koreensis 521_CE), and cell viability was assessed by MTT assays. At concentrations below 0.2 mg/ml, W. koreensis 521_CE did not exert any cytotoxic effect in 3T3-L1 cells. However, treatment with W. koreensis 521_CE significantly inhibited adipocyte differentiation, as assessed by morphological analysis and Oil Red O staining of fat. W. koreensis 521_CE treatment (0.2 mg/ml) also reduced lipid accumulation by 24% in fully differentiated 3T3-L1 adipocytes. These findings collectively indicate that Weissella koreensis 521 may help prevent obesity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Weissella%20koreensis%20521" title="Weissella koreensis 521">Weissella koreensis 521</a>, <a href="https://publications.waset.org/abstracts/search?q=3T3-L1%20cells" title=" 3T3-L1 cells"> 3T3-L1 cells</a>, <a href="https://publications.waset.org/abstracts/search?q=adipocyte%20differentiation" title=" adipocyte differentiation"> adipocyte differentiation</a>, <a href="https://publications.waset.org/abstracts/search?q=obesity" title=" obesity"> obesity</a> </p> <a href="https://publications.waset.org/abstracts/2455/the-inhibitory-effect-of-weissella-koreensis-521-isolated-from-kimchi-on-3t3-l1-adipocyte-differentiation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/2455.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">252</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4797</span> Migration as a Climate Change Adaptation Strategy: A Conceptual Equation for Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Elisha%20Kyirem">Elisha Kyirem</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Undoubtedly, climate change is a major global challenge that could threaten the very foundation upon which life on earth is anchored, with its impacts on human mobility attracting the attention of policy makers and researchers. There is an increasing body of literature and case studies suggesting that migration could be a way through which the vulnerable move away from areas exposed to climate extreme events to improve their lives and that of their families. This presents migration as a way through which people voluntarily move to seek opportunities that could help reduce their exposure and avoid danger from climate events. Thus, migration is seen as a proactive adaptation strategy aimed at building resilience and improving livelihoods to enable people to adapt to future changing events. However, there has not been any mathematical equation linking migration and climate change adaptation. Drawing from literature in development studies, this paper develops an equation that seeks to link the relationship between migration and climate change adaptation. The mathematical equation establishes the linkages between migration, resilience, poverty reduction and vulnerability, and these the paper maintains, are the key variables for conceptualizing the migration-climate change adaptation nexus. The paper then tests the validity of the equation using the sustainable livelihood framework and publicly available data on migration and tourism in Ghana. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=migration" title="migration">migration</a>, <a href="https://publications.waset.org/abstracts/search?q=adaptation" title=" adaptation"> adaptation</a>, <a href="https://publications.waset.org/abstracts/search?q=climate%20change" title=" climate change"> climate change</a>, <a href="https://publications.waset.org/abstracts/search?q=adaptation" title=" adaptation"> adaptation</a>, <a href="https://publications.waset.org/abstracts/search?q=poverty%20reduction" title=" poverty reduction"> poverty reduction</a> </p> <a href="https://publications.waset.org/abstracts/78131/migration-as-a-climate-change-adaptation-strategy-a-conceptual-equation-for-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/78131.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">395</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4796</span> Targeting Tumour Survival and Angiogenic Migration after Radiosensitization with an Estrone Analogue in an in vitro Bone Metastasis Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jolene%20M.%20Helena">Jolene M. Helena</a>, <a href="https://publications.waset.org/abstracts/search?q=Annie%20M.%20Joubert"> Annie M. Joubert</a>, <a href="https://publications.waset.org/abstracts/search?q=Peace%20Mabeta"> Peace Mabeta</a>, <a href="https://publications.waset.org/abstracts/search?q=Magdalena%20Coetzee"> Magdalena Coetzee</a>, <a href="https://publications.waset.org/abstracts/search?q=Roy%20Lakier"> Roy Lakier</a>, <a href="https://publications.waset.org/abstracts/search?q=Anne%20E.%20Mercier"> Anne E. Mercier</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Targeting the distant tumour and its microenvironment whilst preserving bone density is important in improving the outcomes of patients with bone metastases. 2-Ethyl-3-O-sulphamoyl-estra1,3,5(10)16-tetraene (ESE-16) is an in-silico-designed 2- methoxyestradiol analogue which aimed at enhancing the parent compound’s cytotoxicity and providing a more favourable pharmacokinetic profile. In this study, the potential radiosensitization effects of ESE-16 were investigated in an in vitro bone metastasis model consisting of murine pre-osteoblastic (MC3T3-E1) and pre-osteoclastic (RAW 264.7) bone cells, metastatic prostate (DU 145) and breast (MDA-MB-231) cancer cells, as well as human umbilical vein endothelial cells (HUVECs). Cytotoxicity studies were conducted on all cell lines via spectrophotometric quantification of 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide. The experimental set-up consisted of flow cytometric analysis of cell cycle progression and apoptosis detection (Annexin V-fluorescein isothiocyanate) to determine the lowest ESE-16 and radiation doses to induce apoptosis and significantly reduce cell viability. Subsequent experiments entailed a 24-hour low-dose ESE-16-exposure followed by a single dose of radiation. Termination proceeded 2, 24 or 48 hours thereafter. The effect of the combination treatment was investigated on osteoclasts via tartrate-resistant acid phosphatase (TRAP) activity- and actin ring formation assays. Tumour cell experiments included investigation of mitotic indices via haematoxylin and eosin staining; pro-apoptotic signalling via spectrophotometric quantification of caspase 3; deoxyribonucleic acid (DNA) damage via micronuclei analysis and histone H2A.X phosphorylation (γ-H2A.X); and Western blot analyses of bone morphogenetic protein-7 and matrix metalloproteinase-9. HUVEC experiments included flow cytometric quantification of cell cycle progression and free radical production; fluorescent examination of cytoskeletal morphology; invasion and migration studies on an xCELLigence platform; and Western blot analyses of hypoxia-inducible factor 1-alpha and vascular endothelial growth factor receptor 1 and 2. Tumour cells yielded half-maximal growth inhibitory concentration (GI50) values in the nanomolar range. ESE-16 concentrations of 235 nM (DU 145) and 176 nM (MDA-MB-231) and a radiation dose of 4 Gy were found to be significant in cell cycle and apoptosis experiments. Bone and endothelial cells were exposed to the same doses as DU 145 cells. Cytotoxicity studies on bone cells reported that RAW 264.7 cells were more sensitive to the combination treatment than MC3T3-E1 cells. Mature osteoclasts were more sensitive than pre-osteoclasts with respect to TRAP activity. However, actin ring morphology was retained. The mitotic arrest was evident in tumour and endothelial cells in the mitotic index and cell cycle experiments. Increased caspase 3 activity and superoxide production indicated pro-apoptotic signalling in tumour and endothelial cells. Increased micronuclei numbers and γ-H2A.X foci indicated increased DNA damage in tumour cells. Compromised actin and tubulin morphologies and decreased invasion and migration were observed in endothelial cells. Western blot analyses revealed reduced metastatic and angiogenic signalling. ESE-16-induced radiosensitization inhibits metastatic signalling and tumour cell survival whilst preferentially preserving bone cells. This low-dose combination treatment strategy may promote the quality of life of patients with metastatic bone disease. Future studies will include 3-dimensional in-vitro and murine in-vivo models. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=angiogenesis" title="angiogenesis">angiogenesis</a>, <a href="https://publications.waset.org/abstracts/search?q=apoptosis" title=" apoptosis"> apoptosis</a>, <a href="https://publications.waset.org/abstracts/search?q=bone%20metastasis" title=" bone metastasis"> bone metastasis</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer" title=" cancer"> cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20migration" title=" cell migration"> cell migration</a>, <a href="https://publications.waset.org/abstracts/search?q=cytoskeleton" title=" cytoskeleton"> cytoskeleton</a>, <a href="https://publications.waset.org/abstracts/search?q=DNA%20damage" title=" DNA damage"> DNA damage</a>, <a href="https://publications.waset.org/abstracts/search?q=ESE-16" title=" ESE-16"> ESE-16</a>, <a href="https://publications.waset.org/abstracts/search?q=radiosensitization." title=" radiosensitization."> radiosensitization.</a> </p> <a href="https://publications.waset.org/abstracts/102128/targeting-tumour-survival-and-angiogenic-migration-after-radiosensitization-with-an-estrone-analogue-in-an-in-vitro-bone-metastasis-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/102128.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">162</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4795</span> The Involvement of the Homing Receptors CCR7 and CD62L in the Pathogenesis of Graft-Versus-Host Disease</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Federico%20Herrera">Federico Herrera</a>, <a href="https://publications.waset.org/abstracts/search?q=Valle%20Gomez%20Garc%C3%ADa%20de%20Soria"> Valle Gomez García de Soria</a>, <a href="https://publications.waset.org/abstracts/search?q=Itxaso%20Portero%20Sainz"> Itxaso Portero Sainz</a>, <a href="https://publications.waset.org/abstracts/search?q=Carlos%20Fern%C3%A1ndez%20Arandojo"> Carlos Fernández Arandojo</a>, <a href="https://publications.waset.org/abstracts/search?q=Mercedes%20Royg"> Mercedes Royg</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20Marcos%20Jimenez"> Ana Marcos Jimenez</a>, <a href="https://publications.waset.org/abstracts/search?q=Anna%20Kreutzman"> Anna Kreutzman</a>, <a href="https://publications.waset.org/abstracts/search?q=Cecilia%20Mu%C3%B1ozCalleja"> Cecilia MuñozCalleja </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Graft-versus-host disease (GVHD) still remains the major complication associated with allogeneic stem cell transplantation (SCT). The pathogenesis involves migration of donor naïve T-cells into recipient secondary lymphoid organs. Two molecules are important in this process: CD62L and CCR7, which are characteristically expressed in naïve/central memory T-cells. With this background, we aimed to study the influence of CCR7 and CD62L on donor lymphocytes in the development and severity of GVHD. Material and methods: This single center study included 98 donor-recipient pairs. Samples were collected prospectively from the apheresis product and phenotyped by flow cytometry. CCR7 and CD62L expression in CD4+ and CD8+ T-cells were compared between patients who developed acute (n=40) or chronic GVHD (n=33) and those who did not (n=38). Results: The patients who developed acute GVHD were transplanted with a higher percentage of CCR7+CD4+ T-cells (p = 0.05) compared to the no GVHD group. These results were confirmed when these patients were divided in degrees according to the severity of the disease; the more severe disease, the higher percentage of CCR7+CD4+ T-cells. Conversely, chronic GVHD patients received a higher percentage of CCR7+CD8+ T-cells (p=0.02) in comparison to those who did not develop the complication. These data were also confirmed when patients were subdivided in degrees of the disease severity. A multivariable analysis confirmed that percentage of CCR7+CD4+ T-cells is a predictive factor of acute GVHD whereas the percentage of CCR7+CD8+ T-cells is a predictive factor of chronic GVHD. In vitro functional assays (migration and activation assays) supported the idea of CCR7+ T-cells were involved in the development of GVHD. As low levels of CD62L expression were detected in all apheresis products, we tested the hypothesis that CD62L was shed during apheresis procedure. Comparing CD62L surface levels in T-cells from the same donor immediately before collecting the apheresis product, and the final apheresis product we found that this process down-regulated CD62L in both CD4+ and CD8+ T cells (p=0.008). Interestingly, when CD62L levels were analysed in days 30 or 60 after engraftment, they recovered to baseline (p=0.008). However, to investigate the relation between CD62L expression and the development of GVHD in the recipient samples after the engraftment, no differences were observed comparing patients with GVHD to those who did not develop the disease. Discussion: Our prospective study indicates that the CCR7+ T-cells from the donor, which include naïve and central memory T-cells, contain the alloreactive cells with a high ability to mediate GVHD (in the case of both migration and activation). Therefore we suggest that the proportion and functional properties of CCR7+CD4+ and CCR7+CD8+ T-cells in the apheresis could act as a predictive biomarker to both acute and chronic GVHD respectively. Importantly, our study precludes that CD62L is lost in the apheresis and therefore it is not a reliable biomarker for the development of GVHD. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=CCR7" title="CCR7">CCR7</a>, <a href="https://publications.waset.org/abstracts/search?q=CD62L" title=" CD62L"> CD62L</a>, <a href="https://publications.waset.org/abstracts/search?q=GVHD" title=" GVHD"> GVHD</a>, <a href="https://publications.waset.org/abstracts/search?q=SCT" title=" SCT"> SCT</a> </p> <a href="https://publications.waset.org/abstracts/31277/the-involvement-of-the-homing-receptors-ccr7-and-cd62l-in-the-pathogenesis-of-graft-versus-host-disease" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31277.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">287</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4794</span> Internal Migration and Poverty Dynamic Analysis Using a Bayesian Approach: The Tunisian Case</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amal%20Jmaii">Amal Jmaii</a>, <a href="https://publications.waset.org/abstracts/search?q=Damien%20Rousseliere"> Damien Rousseliere</a>, <a href="https://publications.waset.org/abstracts/search?q=Besma%20Belhadj"> Besma Belhadj</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We explore the relationship between internal migration and poverty in Tunisia. We present a methodology combining potential outcomes approach with multiple imputation to highlight the effect of internal migration on poverty states. We find that probability of being poor decreases when leaving the poorest regions (the west areas) to the richer regions (greater Tunis and the east regions). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=internal%20migration" title="internal migration">internal migration</a>, <a href="https://publications.waset.org/abstracts/search?q=potential%20outcomes%20approach" title=" potential outcomes approach"> potential outcomes approach</a>, <a href="https://publications.waset.org/abstracts/search?q=poverty%20dynamics" title=" poverty dynamics"> poverty dynamics</a>, <a href="https://publications.waset.org/abstracts/search?q=Tunisia" title=" Tunisia"> Tunisia</a> </p> <a href="https://publications.waset.org/abstracts/51041/internal-migration-and-poverty-dynamic-analysis-using-a-bayesian-approach-the-tunisian-case" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/51041.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">312</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4793</span> Chemotactic Behaviour of Human Mesenchymal Stem Cells in Response to Silicate Substituted Hydroxyapatite</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dinara%20Ikramova">Dinara Ikramova</a>, <a href="https://publications.waset.org/abstracts/search?q=Karin%20A.%20Hing"> Karin A. Hing</a>, <a href="https://publications.waset.org/abstracts/search?q=Simon%20C.%20F.%20Rawlinson"> Simon C. F. Rawlinson</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Silicate-substituted hydroxyapatite (SiHA) has been shown to enhance bone regeneration in vivo compared with phase pure stoichiometric hydroxyapatite. Evidence suggests that substrate chemistry dependent formation of a permissive protein layer on the surface of synthetic bone graft substitute materials is key for bioactivity and cell attachment. However, little information is available on whether the substrate chemistry may affect cell migration and recruitment. The aim of this study is to investigate whether or not human Mesenchymal Stem Cells (hMSCs) exhibit a chemotactic response to SiHA porous granules and if it can be linked to either the ion exchange or protein sequestering and enrichment on the surface of the material. 150mg of SiHA granules with 80% total porosity and 20% strut porosity were incubated in 1ml of either Serum Free Media (SFM) or 10% Serum Containing Media (SCM) under static cell culture conditions (37°C, 5% CO2) in absence of cells. Protein sequestering and exchange of calcium, phosphate and silicate ions were analysed at 0.5, 1, 2, 4, 8, 16 and 24 hours with n=12 per time point. Migration of hMSCs in the presence of 150mg of SiHA granules was assessed over 24 hours using a modified transwell migration system in either SFM or SCM (n=6) with 30% serum containing media acting as a positive control. At 24 hours protein sequestering and ionic exchange were analysed, and the number of cells was quantified using a high throughput confocal microscope (IN Cell Analyser 6000). In acellular condition, both calcium and phosphate ion concentrations in media showed a decrease at 24 hours which was greater in SFM than in SCM. This suggests possible formation and precipitation of a bone like apatite on the surface of SiHA. Reduction in this activity observed in SCM indicates that the presence of serum proteins is interfering with the ion exchange at the material and media interface. Adsorbed protein levels showed fluctuation over time followed by sharp decrease at 24 hours, suggesting a possible protein rearrangement on the surface of the material. The ion analysis performed on SFM and SCM after 24-hour incubation with cells in the presence of granules showed a greater reduction in phosphate concentration in both SFM and SCM compared to phosphate levels in acellular condition. Silicate concentration in SCM increased from 1.6mM (absence of cells) to 5.1mM (presence of cells). This indicates that the cells are promoting the uptake of phosphate and release of silicate ions. No significant change was seen in levels of adsorbed proteins in the presence and absence of cells. Further analysis is required to determine whether the species of these proteins change over time. The analysis of cell migration after 24-hour incubation showed more cells migrating towards the granules, 12.7% in SFM and 8.3% in SCM, than in positive control, 4.5% in SFM and 3.6% in SCM respectively. These results suggest that SiHA has a chemotactic activity independent of serum proteins. A property which has not previously been demonstrated for a synthetic bone graft material. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cell%20migration" title="cell migration">cell migration</a>, <a href="https://publications.waset.org/abstracts/search?q=hMSCs" title=" hMSCs"> hMSCs</a>, <a href="https://publications.waset.org/abstracts/search?q=SiHA" title=" SiHA"> SiHA</a>, <a href="https://publications.waset.org/abstracts/search?q=transwell%20migration%20system" title=" transwell migration system"> transwell migration system</a> </p> <a href="https://publications.waset.org/abstracts/84858/chemotactic-behaviour-of-human-mesenchymal-stem-cells-in-response-to-silicate-substituted-hydroxyapatite" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/84858.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">131</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4792</span> Geographic Aspects of Egyptian Illegal Migration to Europe </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Ahmed%20Aly%20Hassanien">Mohamed Ahmed Aly Hassanien</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study examines the geographic aspects of Egyptian illegal migration to Europe. It used files of Egyptian government bodies and data obtained from a field study carried out in 2015 on the areas of origin. The study revealed that the phenomenon has passed historically through four phases. Areas of origin are classified geographically into three areas: coastal, river, and interior. The study developed a map for routes of migration which identified the main and secondary routes. The main routes included the Libyan, the Mediterranean and the Arab-Turkish routes. Recently, The Mediterranean route has been the largest and the most dangerous. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=areas%20of%20destination" title="areas of destination">areas of destination</a>, <a href="https://publications.waset.org/abstracts/search?q=areas%20of%20origin" title=" areas of origin"> areas of origin</a>, <a href="https://publications.waset.org/abstracts/search?q=illegal%20migration" title=" illegal migration"> illegal migration</a>, <a href="https://publications.waset.org/abstracts/search?q=routes%20of%20migration" title=" routes of migration"> routes of migration</a> </p> <a href="https://publications.waset.org/abstracts/42595/geographic-aspects-of-egyptian-illegal-migration-to-europe" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42595.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">351</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4791</span> Security Practices of the European Union on Migration: An Analysis of the Frontex Within the Framework of Biopolitics</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gizem%20Ert%C3%BCrk">Gizem Ertürk</a>, <a href="https://publications.waset.org/abstracts/search?q=Nursena%20Din%C3%A7"> Nursena Dinç</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The Aegean area has always been an important transit point for migration; however, the establishment of the European Union gave further impetus to the migration phenomenon and increased the significance of the area within this context. The migration waves have been more visible in the area in recent decades, and particularly after the “2015 Migration Crisis,” this issue has been subject to further securitization in the EU. In this conjuncture, the Frontex, which is an agency set up by the EU in 2005 for the purpose of managing and coordinating the border control efforts, has become more functional in the relevant area, but at the same time, have some questionable actions within the context of human rights. This paper problematizes the rationality behind the existence and practices of such a structure and attempts to make a political and legal analysis of the security practices of the European Union against migration within a framework based on the biopolitics approaches of Michel Foucault and Giorgio Agamben. The dataset of this paper, which focuses on the agency in question by taking it as a case, is formed by making use of the existing literature on the EU’s security policies, the relevant official texts of the Union and Frontex reports on migration practices in and around the Aegean Sea. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=migration" title="migration">migration</a>, <a href="https://publications.waset.org/abstracts/search?q=biopolitics" title=" biopolitics"> biopolitics</a>, <a href="https://publications.waset.org/abstracts/search?q=Frontex" title=" Frontex"> Frontex</a>, <a href="https://publications.waset.org/abstracts/search?q=security" title=" security"> security</a>, <a href="https://publications.waset.org/abstracts/search?q=European%20union" title=" European union"> European union</a>, <a href="https://publications.waset.org/abstracts/search?q=securitization" title=" securitization"> securitization</a> </p> <a href="https://publications.waset.org/abstracts/148698/security-practices-of-the-european-union-on-migration-an-analysis-of-the-frontex-within-the-framework-of-biopolitics" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/148698.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">137</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4790</span> Migration and Displacement: A Study on the Impact of Bangladeshi and Nepali Migration to North-Eastern India</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sri%20Mahan%20Borah">Sri Mahan Borah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The issue of migration and displacement is considered so sensitive that states have often linked it with their sovereignty, independence and even existence. Therefor, even in the era of globalisation no nation-state is ready to compromise with its territorial boundaries. The problem of migration and displacement has generated a range of socio-political, economic, ethnic, and communal tensions in India in general and northeastern States in particular. In such situation it becomes unpreventable to look over the issue so that a viable elucidation may emerge. The present paper is an attempt to understand the impact of Bangladeshi and Nepali migration to North-Eastern states of India through historical and analytical methods. In this course it will look into the emergence of the migration and displacement problem, its causes, impacts on security and other issues of national interest especially when the migration is illegal and poses multi-layered challenges to the Indian state. The nature of migration from these countries to India has been dissimilar. This is because of their different historical backgrounds, geographical variants, ethno-religious affinities, political systems and bilateral arrangements with India. It concludes inter alia that, India’s borders with Bangladesh and Nepal must be regulated and that resident migrants need to be strategically dealt with, keeping in mind age-old relationships with these countries and, more importantly, the nature and construct of our geography. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=migration" title="migration">migration</a>, <a href="https://publications.waset.org/abstracts/search?q=displacement" title=" displacement"> displacement</a>, <a href="https://publications.waset.org/abstracts/search?q=North-East" title=" North-East"> North-East</a>, <a href="https://publications.waset.org/abstracts/search?q=India" title=" India"> India</a> </p> <a href="https://publications.waset.org/abstracts/9929/migration-and-displacement-a-study-on-the-impact-of-bangladeshi-and-nepali-migration-to-north-eastern-india" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9929.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">406</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4789</span> Regulation of RON-Receptor Tyrosine Kinase Functions by Epstein-Barr-Virus (EBV) Nuclear Antigen 3C</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Roshika%20Tyagi">Roshika Tyagi</a>, <a href="https://publications.waset.org/abstracts/search?q=Shuvomoy%20Banerjee"> Shuvomoy Banerjee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Among various diseases, cancer has become a huge threat to human beings globally. In the context of viral infection, Epstein–Barr virus (EBV) infection is ubiquitous in nature world-wide as well as in India. Recepteur d’Origine Nantais (RON) receptor tyrosine kinase is overexpressed in Lymphoblastoid cell lines (LCLs) but undetectable in primary B-cells. Biologically, RON expression was found to be essential for EBV transformed LCLs proliferation. In our study, we investigated whether EBV latent antigen EBNA3C is playing a crucial role in regulating RON receptor tyrosine kinase function in EBV-induced malignancies. Interestingly, we observed that expression pattern of RON was modulated by EBNA3C in EBV transformed LCLs compared with EBV negative BJAB cell line by PCR and western blot analysis. Moreover, in the absence of EBNA3C, RON expression was found low in western blot and immunofluorescence analysis and cell proliferation rate was significantly reduced in LCLs by cell viability assays. Therefore, our study clearly indicating the potential role of EBNA3C expressed in EBV-infected B-cells for modulating the functions of oncogenic kinases that leads to EBV induced B-cell transformation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=apoptosis" title="apoptosis">apoptosis</a>, <a href="https://publications.waset.org/abstracts/search?q=cell%20proliferation" title=" cell proliferation"> cell proliferation</a>, <a href="https://publications.waset.org/abstracts/search?q=Epstein%E2%80%93barr%20virus" title=" Epstein–barr virus"> Epstein–barr virus</a>, <a href="https://publications.waset.org/abstracts/search?q=receptor%20tyrosine%20kinase" title=" receptor tyrosine kinase"> receptor tyrosine kinase</a> </p> <a href="https://publications.waset.org/abstracts/66176/regulation-of-ron-receptor-tyrosine-kinase-functions-by-epstein-barr-virus-ebv-nuclear-antigen-3c" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66176.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">229</span> </span> </div> </div> <ul class="pagination"> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=cell%20migration%20assays&page=1" rel="prev">&lsaquo;</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=cell%20migration%20assays&page=1">1</a></li> <li class="page-item active"><span class="page-link">2</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=cell%20migration%20assays&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=cell%20migration%20assays&page=4">4</a></li> <li class="page-item"><a class="page-link" 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