Production, characterization and control of MenB-vaccine "Folkehelsa": an outer membrane vesicle vaccine against group B meningococcal disease

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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="VSOb3DbvqvdcUoiTOMFppcxTwPJQN93B5xViueUEk6oYfg2ore6Ttx6wZSUrmjoo"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="VSOb3DbvqvdcUoiTOMFppcxTwPJQN93B5xViueUEk6oYfg2ore6Ttx6wZSUrmjoo"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="VSOb3DbvqvdcUoiTOMFppcxTwPJQN93B5xViueUEk6oYfg2ore6Ttx6wZSUrmjoo"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="VSOb3DbvqvdcUoiTOMFppcxTwPJQN93B5xViueUEk6oYfg2ore6Ttx6wZSUrmjoo"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="1812438"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/1812438/citations/" data-citation-style="nlm" data-pubmed-format-link="/1812438/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="1812438" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger" aria-label="Save article in MyNCBI collections." data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_button" data-collections-open-dialog-enabled="false" data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F1812438%2F%23open-collections-dialog" data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog" class="dialog collections-dialog" aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/" data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-myncbi-max-collection-name-length="100" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="VSOb3DbvqvdcUoiTOMFppcxTwPJQN93B5xViueUEk6oYfg2ore6Ttx6wZSUrmjoo"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="sidebar-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="social-sharing"> <h3 class="title"> Share </h3> <ul class="social-sharing-links usa-unstyled-list"> <li> <a 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NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"NIPH Ann"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"NIPH Ann"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">1991 Dec;14(2):67-79; discussion 79-80.</span> </div> </div> <h1 class="heading-title"> Production, characterization and control of MenB-vaccine "Folkehelsa": an outer membrane vesicle vaccine against group B meningococcal disease </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Fredriksen+JH&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="J H Fredriksen">J H Fredriksen</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Vaccine, National Institute of Public Health, Oslo." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rosenqvist+E&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="E Rosenqvist">E Rosenqvist</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wedege+E&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="E Wedege">E Wedege</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bryn+K&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="K Bryn">K Bryn</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bjune+G&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="G Bjune">G Bjune</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Fr%C3%B8holm+LO&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="L O Frøholm">L O Frøholm</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Lindbak+AK&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="A K Lindbak">A K Lindbak</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=M%C3%B8gster+B&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="B Møgster">B 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id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> Department of Vaccine, National Institute of Public Health, Oslo.</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">1812438</strong> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <h1 class="heading-title"> Production, characterization and control of MenB-vaccine "Folkehelsa": an outer membrane vesicle vaccine against group B meningococcal disease </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">J H Fredriksen</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> NIPH Ann<span class="citation-separator">.</span> </span> <span class="date"> <span class="citation-year">1991 Dec</span><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/1812438/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"> <button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"> <span class="button-label">Display options</span> </button> <div class="dropdown" hidden> 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data-ga-action="add_to_search" data-ga-label='"NIPH Ann"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">1991 Dec;14(2):67-79; discussion 79-80.</span> </div> </div> <div class="expanded-authors" id="short-view-expanded-authors"> <div class="authors"> <h3 class="title"> Authors </h3> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Fredriksen+JH&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="J H Fredriksen">J H Fredriksen</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Vaccine, National Institute of Public Health, Oslo." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rosenqvist+E&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="E Rosenqvist">E Rosenqvist</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wedege+E&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="E Wedege">E Wedege</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bryn+K&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="K Bryn">K Bryn</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bjune+G&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="G Bjune">G Bjune</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" 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class="authors-list-item "><a class="full-name" href="/?term=Rye+U&cauthor_id=1812438" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="U Rye">U Rye</a><span class="comma etal">, et al.</span></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Department of Vaccine, National Institute of Public Health, Oslo.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">1812438</strong> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with 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id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> A vaccine against serogroup B meningococcal disease has been prepared from a B:15:P1.7,16 meningococcal strain (44/76) by fermentor growth and extraction of the bacteria with the detergent deoxycholate. Outer membrane vesicles (OMV) were purified by ultracentrifugation and adsorbed to aluminium hydroxide adjuvant. OMV contained the major class 1, 3, 4 and 5 proteins and some minor high molecular weight protein components. Relative to protein, the vaccine also contained about 8% phospholipid, 7% lipopolysaccharide and 16% deoxycholate. The product was generally non-pyrogenic to humans in ordinary doses and was highly immunogenic in mice and humans. Production and control steps, physical, chemical and immunological data for the vaccine are described. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" data-ga-category="literature_resources" data-ga-action="disclaimer_link" data-ga-label="under_abstract">PubMed Disclaimer</a> </p> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/1687481/" ref="article_id=1687481&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="1687481" data-ga-label=""> Human antibody responses after vaccination with the Norwegian group B meningococcal outer membrane vesicle vaccine: results from ELISA studies. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Rosenqvist E, Høiby EA, Bjune G, Bryn K, Closs O, Feiring B, Klem A, Nøkleby H, Frølm LO.</span> <span class="docsum-authors short-authors">Rosenqvist E, et al.</span> <span class="docsum-journal-citation full-journal-citation">NIPH Ann. 1991 Dec;14(2):169-79; discussion 180-1.</span> <span class="docsum-journal-citation short-journal-citation">NIPH Ann. 1991.</span> <span class="citation-part">PMID: <span class="docsum-pmid">1687481</span></span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/1812439/" ref="article_id=1812439&linksrc=similar_articles_link&ordinalpos=2" data-ga-category="similar_article" data-ga-action="1812439" data-ga-label=""> Design of clinical trials with an outer membrane vesicle vaccine against systemic serogroup B meningococcal disease in Norway. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Bjune G, Closs O, Frøholm LO, Grønnesby JK, Høiby EA, Nøkleby H.</span> <span class="docsum-authors short-authors">Bjune G, et al.</span> <span class="docsum-journal-citation full-journal-citation">NIPH Ann. 1991 Dec;14(2):81-91; discussion 91-3.</span> <span class="docsum-journal-citation short-journal-citation">NIPH Ann. 1991.</span> <span class="citation-part">PMID: <span class="docsum-pmid">1812439</span></span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/9554288/" ref="article_id=9554288&linksrc=similar_articles_link&ordinalpos=3" data-ga-category="similar_article" data-ga-action="9554288" data-ga-label=""> Effect of aluminium hydroxide and meningococcal serogroup C capsular polysaccharide on the immunogenicity and reactogenicity of a group B Neisseria meningitidis outer membrane vesicle vaccine. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Rosenqvist E, Høiby EA, Bjune G, Aase A, Halstensen A, Lehmann AK, Paulssen J, Holst J, Michaelsen TE, Nøkleby H, Frøholm LO, Closs O.</span> <span class="docsum-authors short-authors">Rosenqvist E, et al.</span> <span class="docsum-journal-citation full-journal-citation">Dev Biol Stand. 1998;92:323-33.</span> <span class="docsum-journal-citation short-journal-citation">Dev Biol Stand. 1998.</span> <span class="citation-part">PMID: <span class="docsum-pmid">9554288</span></span> <span class="publication-type spaced-citation-item citation-part">Clinical Trial.</span> </div> </div> </li> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/19481313/" ref="article_id=19481313&linksrc=similar_articles_link&ordinalpos=4" data-ga-category="similar_article" data-ga-action="19481313" data-ga-label=""> Properties and clinical performance of vaccines containing outer membrane vesicles from Neisseria meningitidis. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Holst J, Martin D, Arnold R, Huergo CC, Oster P, O'Hallahan J, Rosenqvist E.</span> <span class="docsum-authors short-authors">Holst J, et al.</span> <span class="docsum-journal-citation full-journal-citation">Vaccine. 2009 Jun 24;27 Suppl 2:B3-12. doi: 10.1016/j.vaccine.2009.04.071. 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class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Humans" tabindex="0" aria-controls="keyword-actions-mesh-terms-8" aria-expanded="false" data-pinger-ignore> Humans </button><div id="keyword-actions-mesh-terms-8" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Humans"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Humans"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Humans"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Humans" data-ga-category="search_mesh" 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href="/?term=%22Immunoblotting%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Immunoblotting%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Immunoblotting"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Immunoblotting"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Immunoblotting" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Immunoblotting"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Immunoblotting"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Immunoblotting"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Incidence" tabindex="0" aria-controls="keyword-actions-mesh-terms-10" aria-expanded="false" data-pinger-ignore> Incidence </button><div id="keyword-actions-mesh-terms-10" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Incidence"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Incidence%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Incidence%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Incidence"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Incidence"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Incidence" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Incidence"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Incidence"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Incidence"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Meningitis, Meningococcal / epidemiology" tabindex="0" aria-controls="keyword-actions-mesh-terms-11" aria-expanded="false" data-pinger-ignore> Meningitis, Meningococcal / epidemiology </button><div id="keyword-actions-mesh-terms-11" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Meningitis, Meningococcal / epidemiology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Meningitis%2C+Meningococcal%2Fepidemiology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Meningitis%2C+Meningococcal%2Fepidemiology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Meningitis, Meningococcal/epidemiology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Meningitis, Meningococcal / epidemiology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Meningitis%2C+Meningococcal" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Meningitis, Meningococcal / epidemiology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Meningitis, Meningococcal/epidemiology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Meningitis, Meningococcal/epidemiology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Meningitis, Meningococcal / microbiology" tabindex="0" aria-controls="keyword-actions-mesh-terms-12" aria-expanded="false" data-pinger-ignore> Meningitis, Meningococcal / microbiology </button><div id="keyword-actions-mesh-terms-12" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Meningitis, Meningococcal / microbiology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Meningitis%2C+Meningococcal%2Fmicrobiology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Meningitis%2C+Meningococcal%2Fmicrobiology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Meningitis, Meningococcal/microbiology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Meningitis, Meningococcal / microbiology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Meningitis%2C+Meningococcal" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Meningitis, Meningococcal / microbiology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Meningitis, Meningococcal/microbiology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Meningitis, Meningococcal/microbiology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Meningitis, Meningococcal / prevention & control*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-13" aria-expanded="false" data-pinger-ignore> Meningitis, Meningococcal / prevention & control* </button><div id="keyword-actions-mesh-terms-major-13" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Meningitis, Meningococcal / prevention & control*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Meningitis%2C+Meningococcal%2Fprevention+and+control%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Meningitis%2C+Meningococcal%2Fprevention+and+control%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Meningitis, Meningococcal/prevention and control"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Meningitis, Meningococcal / prevention & control*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Meningitis%2C+Meningococcal" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Meningitis, Meningococcal / prevention & control*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Meningitis, Meningococcal/prevention and control"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Meningitis, Meningococcal/prevention and control"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Meningococcal Vaccines" tabindex="0" aria-controls="keyword-actions-mesh-terms-14" aria-expanded="false" data-pinger-ignore> Meningococcal Vaccines </button><div id="keyword-actions-mesh-terms-14" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Meningococcal Vaccines"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Meningococcal+Vaccines%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Meningococcal+Vaccines%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Meningococcal Vaccines"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Meningococcal Vaccines"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Meningococcal+Vaccines" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Meningococcal Vaccines"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Meningococcal Vaccines"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Meningococcal Vaccines"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Norway / epidemiology" tabindex="0" aria-controls="keyword-actions-mesh-terms-15" aria-expanded="false" data-pinger-ignore> Norway / epidemiology </button><div id="keyword-actions-mesh-terms-15" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Norway / epidemiology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Norway%2Fepidemiology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Norway%2Fepidemiology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Norway/epidemiology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Norway / epidemiology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Norway" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Norway / epidemiology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Norway/epidemiology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Norway/epidemiology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Polysaccharides, Bacterial / immunology*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-16" aria-expanded="false" data-pinger-ignore> Polysaccharides, Bacterial / immunology* </button><div id="keyword-actions-mesh-terms-major-16" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Polysaccharides, Bacterial / immunology*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Polysaccharides%2C+Bacterial%2Fimmunology%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Polysaccharides%2C+Bacterial%2Fimmunology%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Polysaccharides, Bacterial/immunology"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Polysaccharides, Bacterial / immunology*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Polysaccharides%2C+Bacterial" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Polysaccharides, Bacterial / immunology*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Polysaccharides, Bacterial/immunology"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Polysaccharides, Bacterial/immunology"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Quality Control" tabindex="0" aria-controls="keyword-actions-mesh-terms-17" aria-expanded="false" data-pinger-ignore> Quality Control </button><div id="keyword-actions-mesh-terms-17" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Quality Control"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Quality+Control%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Quality+Control%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Quality Control"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Quality Control"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Quality+Control" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Quality Control"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Quality Control"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Quality Control"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Serotyping" tabindex="0" aria-controls="keyword-actions-mesh-terms-18" aria-expanded="false" data-pinger-ignore> Serotyping </button><div id="keyword-actions-mesh-terms-18" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Serotyping"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Serotyping%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Serotyping%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Serotyping"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Serotyping"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Serotyping" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Serotyping"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Serotyping"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Serotyping"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Bacterial Outer Membrane Proteins" tabindex="0" aria-controls="keyword-actions-substances-0" aria-expanded="false" data-pinger-ignore> Bacterial Outer Membrane Proteins </button><div id="keyword-actions-substances-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Bacterial Outer Membrane Proteins"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Bacterial+Outer+Membrane+Proteins%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Bacterial+Outer+Membrane+Proteins%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Bacterial Outer Membrane Proteins"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Bacterial Outer Membrane Proteins"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Bacterial+Outer+Membrane+Proteins%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Bacterial Outer Membrane Proteins"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Bacterial Outer Membrane Proteins"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Bacterial Outer Membrane Proteins"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Bacterial Vaccines" tabindex="0" aria-controls="keyword-actions-substances-1" aria-expanded="false" data-pinger-ignore> Bacterial Vaccines </button><div id="keyword-actions-substances-1" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Bacterial Vaccines"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Bacterial+Vaccines%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Bacterial+Vaccines%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Bacterial Vaccines"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Bacterial Vaccines"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Bacterial+Vaccines%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Bacterial Vaccines"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Bacterial Vaccines"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Bacterial Vaccines"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Meningococcal Vaccines" tabindex="0" aria-controls="keyword-actions-substances-2" aria-expanded="false" data-pinger-ignore> Meningococcal Vaccines </button><div id="keyword-actions-substances-2" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Meningococcal Vaccines"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a 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Production, characterization and control of MenB-vaccine "Folkehelsa": an outer membrane vesicle vaccine against group B meningococcal disease - PubMed