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vector-toc-level-2"> <a class="vector-toc-link" href="#Special_populations"> <div class="vector-toc-text"> 1.5 Special populations </div> </a> <ul id="toc-Special_populations-sublist" class="vector-toc-list"> <li id="toc-Pregnancy_and_breastfeeding" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Pregnancy_and_breastfeeding"> <div class="vector-toc-text"> 1.5.1 Pregnancy and breastfeeding </div> </a> <ul id="toc-Pregnancy_and_breastfeeding-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Children" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Children"> <div class="vector-toc-text"> 1.5.2 Children </div> </a> <ul id="toc-Children-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Geriatric_use" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Geriatric_use"> <div class="vector-toc-text"> 1.5.3 Geriatric use </div> </a> <ul id="toc-Geriatric_use-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Available_forms" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Available_forms"> <div class="vector-toc-text"> 1.6 Available forms </div> </a> <ul id="toc-Available_forms-sublist" class="vector-toc-list"> <li id="toc-Intravenous" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Intravenous"> <div class="vector-toc-text"> 1.6.1 Intravenous </div> </a> <ul id="toc-Intravenous-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Intramuscular_or_subcutaneous" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Intramuscular_or_subcutaneous"> <div class="vector-toc-text"> 1.6.2 Intramuscular or subcutaneous </div> </a> <ul id="toc-Intramuscular_or_subcutaneous-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Intranasal" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Intranasal"> <div class="vector-toc-text"> 1.6.3 Intranasal </div> </a> <ul id="toc-Intranasal-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-Side_effects" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Side_effects"> <div class="vector-toc-text"> 2 Side effects </div> </a> <ul id="toc-Side_effects-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pharmacology" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Pharmacology"> <div class="vector-toc-text"> 3 Pharmacology </div> </a> <button aria-controls="toc-Pharmacology-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Pharmacology subsection </button> <ul id="toc-Pharmacology-sublist" class="vector-toc-list"> <li id="toc-Pharmacodynamics" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Pharmacodynamics"> <div class="vector-toc-text"> 3.1 Pharmacodynamics </div> </a> <ul id="toc-Pharmacodynamics-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pharmacokinetics" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Pharmacokinetics"> <div class="vector-toc-text"> 3.2 Pharmacokinetics </div> </a> <ul id="toc-Pharmacokinetics-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Chemistry" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Chemistry"> <div class="vector-toc-text"> 4 Chemistry </div> </a> <ul id="toc-Chemistry-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-History" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#History"> <div class="vector-toc-text"> 5 History </div> </a> <ul id="toc-History-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Society_and_culture" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Society_and_culture"> <div class="vector-toc-text"> 6 Society and culture </div> </a> <button aria-controls="toc-Society_and_culture-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle Society and culture subsection </button> <ul id="toc-Society_and_culture-sublist" class="vector-toc-list"> <li id="toc-Misinformation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Misinformation"> <div class="vector-toc-text"> 6.1 Misinformation </div> </a> <ul id="toc-Misinformation-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Names" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Names"> <div class="vector-toc-text"> 6.2 Names </div> </a> <ul id="toc-Names-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Legal_status_and_availability_to_law_enforcement_and_emergency_personnel" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Legal_status_and_availability_to_law_enforcement_and_emergency_personnel"> <div class="vector-toc-text"> 6.3 Legal status and availability to law enforcement and emergency personnel </div> </a> <ul id="toc-Legal_status_and_availability_to_law_enforcement_and_emergency_personnel-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Community_access" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Community_access"> <div class="vector-toc-text"> 6.4 Community access </div> </a> <ul id="toc-Community_access-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> 7 References </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> 8 Further reading </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> 9 External links </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" > Toggle the table of contents </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading">Naloxone</h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 38 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-38" aria-hidden="true" > 38 languages </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%86%D8%A7%D9%84%D9%88%D9%83%D8%B3%D9%88%D9%86" title="نالوكسون – Arabic" lang="ar" hreflang="ar" data-title="نالوكسون" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target">العربية</a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D9%86%D8%A7%D9%84%D9%88%DA%A9%D8%B3%D8%A7%D9%86" title="نالوکسان – South Azerbaijani" lang="azb" hreflang="azb" data-title="نالوکسان" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target">تۆرکجه</a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%9D%D0%B0%D0%BB%D0%BE%D0%BA%D1%81%D0%BE%D0%BD" title="Налоксон – Bulgarian" lang="bg" hreflang="bg" data-title="Налоксон" data-language-autonym="Български" data-language-local-name="Bulgarian" class="interlanguage-link-target">Български</a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Naloxona" title="Naloxona – Catalan" lang="ca" hreflang="ca" data-title="Naloxona" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target">Català</a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Naloxon" title="Naloxon – Czech" lang="cs" hreflang="cs" data-title="Naloxon" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target">Čeština</a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Nalocson" title="Nalocson – Welsh" lang="cy" hreflang="cy" data-title="Nalocson" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target">Cymraeg</a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Naloxon" title="Naloxon – Danish" lang="da" hreflang="da" data-title="Naloxon" data-language-autonym="Dansk" data-language-local-name="Danish" class="interlanguage-link-target">Dansk</a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Naloxon" title="Naloxon – German" lang="de" hreflang="de" data-title="Naloxon" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target">Deutsch</a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%9D%CE%B1%CE%BB%CE%BF%CE%BE%CF%8C%CE%BD%CE%B7" title="Ναλοξόνη – Greek" lang="el" hreflang="el" data-title="Ναλοξόνη" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target">Ελληνικά</a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Naloxona" title="Naloxona – Spanish" lang="es" hreflang="es" data-title="Naloxona" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target">Español</a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Naloxona" title="Naloxona – Basque" lang="eu" hreflang="eu" data-title="Naloxona" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target">Euskara</a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%86%D8%A7%D9%84%D9%88%DA%A9%D8%B3%D8%A7%D9%86" title="نالوکسان – Persian" lang="fa" hreflang="fa" data-title="نالوکسان" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target">فارسی</a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Naloxone" title="Naloxone – French" lang="fr" hreflang="fr" data-title="Naloxone" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target">Français</a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Naloxona" title="Naloxona – Galician" lang="gl" hreflang="gl" data-title="Naloxona" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target">Galego</a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%82%A0%EB%A1%9D%EC%86%90" title="날록손 – Korean" lang="ko" hreflang="ko" data-title="날록손" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target">한국어</a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Nalokson" title="Nalokson – Indonesian" lang="id" hreflang="id" data-title="Nalokson" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target">Bahasa Indonesia</a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Naloxone" title="Naloxone – Italian" lang="it" hreflang="it" data-title="Naloxone" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target">Italiano</a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%A0%D7%9C%D7%95%D7%A7%D7%A1%D7%95%D7%9F" title="נלוקסון – Hebrew" lang="he" hreflang="he" data-title="נלוקסון" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target">עברית</a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Naloxon" title="Naloxon – Hungarian" lang="hu" hreflang="hu" data-title="Naloxon" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target">Magyar</a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Naloxon" title="Naloxon – Dutch" lang="nl" hreflang="nl" data-title="Naloxon" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target">Nederlands</a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%8A%E3%83%AD%E3%82%AD%E3%82%BD%E3%83%B3" title="ナロキソン – Japanese" lang="ja" hreflang="ja" data-title="ナロキソン" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target">日本語</a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Naloxon" title="Naloxon – Norwegian Bokmål" lang="nb" hreflang="nb" data-title="Naloxon" data-language-autonym="Norsk bokmål" data-language-local-name="Norwegian Bokmål" class="interlanguage-link-target">Norsk bokmål</a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%A8%E0%AC%BE%E0%AC%B2%E0%AD%8B%E0%AC%95%E0%AD%8D%E2%80%8C%E0%AC%B8%E0%AD%8B%E0%AC%A8" title="ନାଲୋକ୍‌ସୋନ – Odia" lang="or" hreflang="or" data-title="ନାଲୋକ୍‌ସୋନ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target">ଓଡ଼ିଆ</a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Nalokson" title="Nalokson – Polish" lang="pl" hreflang="pl" data-title="Nalokson" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target">Polski</a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Naloxona" title="Naloxona – Portuguese" lang="pt" hreflang="pt" data-title="Naloxona" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target">Português</a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Naloxon%C4%83" title="Naloxonă – Romanian" lang="ro" hreflang="ro" data-title="Naloxonă" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target">Română</a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9D%D0%B0%D0%BB%D0%BE%D0%BA%D1%81%D0%BE%D0%BD" title="Налоксон – Russian" lang="ru" hreflang="ru" data-title="Налоксон" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target">Русский</a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Naloxone" title="Naloxone – Simple English" lang="en-simple" hreflang="en-simple" data-title="Naloxone" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target">Simple English</a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Nalokson" title="Nalokson – Serbian" lang="sr" hreflang="sr" data-title="Nalokson" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target">Српски / srpski</a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Nalokson" title="Nalokson – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Nalokson" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target">Srpskohrvatski / српскохрватски</a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Naloksoni" title="Naloksoni – Finnish" lang="fi" hreflang="fi" data-title="Naloksoni" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target">Suomi</a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Naloxon" title="Naloxon – Swedish" lang="sv" hreflang="sv" data-title="Naloxon" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target">Svenska</a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%99%E0%B8%B2%E0%B8%A5%E0%B9%87%E0%B8%AD%E0%B8%81%E0%B9%82%E0%B8%8B%E0%B8%99" title="นาล็อกโซน – Thai" lang="th" hreflang="th" data-title="นาล็อกโซน" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target">ไทย</a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Nalokson" title="Nalokson – Turkish" lang="tr" hreflang="tr" data-title="Nalokson" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target">Türkçe</a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%9D%D0%B0%D0%BB%D0%BE%D0%BA%D1%81%D0%BE%D0%BD" title="Налоксон – Ukrainian" lang="uk" hreflang="uk" data-title="Налоксон" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target">Українська</a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Naloxone" title="Naloxone – Vietnamese" lang="vi" hreflang="vi" data-title="Naloxone" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target">Tiếng Việt</a></li><li class="interlanguage-link interwiki-wuu mw-list-item"><a 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dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Opioid receptor antagonist</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Not to be confused with <a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a> or <a href="/wiki/Naloxegol" title="Naloxegol">Naloxegol</a>.</div> <style data-mw-deduplicate="TemplateStyles:r1251242444">.mw-parser-output .ambox{border:1px solid #a2a9b1;border-left:10px solid #36c;background-color:#fbfbfb;box-sizing:border-box}.mw-parser-output .ambox+link+.ambox,.mw-parser-output .ambox+link+style+.ambox,.mw-parser-output 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class="mbox-text-span">This article needs more <a href="/wiki/Wikipedia:Identifying_reliable_sources_(medicine)" title="Wikipedia:Identifying reliable sources (medicine)">reliable medical references</a> for <a href="/wiki/Wikipedia:Verifiability" title="Wikipedia:Verifiability">verification</a> or relies too heavily on <a href="/wiki/Wikipedia:Primary_sources" class="mw-redirect" title="Wikipedia:Primary sources">primary sources</a>. Please review the contents of the article and <a class="external text" href="https://en.wikipedia.org/w/index.php?title=Naloxone&action=edit">add the appropriate references</a> if you can. Unsourced or poorly sourced material may be challenged and <a href="/wiki/Wikipedia:Verifiability#Burden_of_evidence" title="Wikipedia:Verifiability">removed</a>. Find sources: <a rel="nofollow" class="external text" href="https://www.google.com/search?as_eq=wikipedia&q=%22Naloxone%22">"Naloxone"</a> – <a rel="nofollow" class="external text" href="https://www.google.com/search?tbm=nws&q=%22Naloxone%22+-wikipedia&tbs=ar:1">news</a> · <a rel="nofollow" class="external text" href="https://www.google.com/search?&q=%22Naloxone%22&tbs=bkt:s&tbm=bks">newspapers</a> · <a rel="nofollow" class="external text" href="https://www.google.com/search?tbs=bks:1&q=%22Naloxone%22+-wikipedia">books</a> · <a rel="nofollow" class="external text" href="https://scholar.google.com/scholar?q=%22Naloxone%22">scholar</a> · <a rel="nofollow" class="external text" href="https://www.jstor.org/action/doBasicSearch?Query=%22Naloxone%22&acc=on&wc=on">JSTOR</a> (September 2023)</div></td><td class="mbox-imageright"><div class="mbox-image-div"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Star_of_life.svg/52px-Star_of_life.svg.png" decoding="async" width="52" height="50" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Star_of_life.svg/77px-Star_of_life.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Star_of_life.svg/103px-Star_of_life.svg.png 2x" data-file-width="198" data-file-height="192" /></div></td></tr></tbody></table> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Pharmaceutical compound</div> <style data-mw-deduplicate="TemplateStyles:r1269284339">@media screen{html.skin-theme-clientpref-night .mw-parser-output .dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}</style> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title">Naloxone</caption><tbody><tr><td colspan="2" class="infobox-image"><a href="/wiki/File:Naloxone.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Naloxone.svg/225px-Naloxone.svg.png" decoding="async" width="225" height="187" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Naloxone.svg/338px-Naloxone.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Naloxone.svg/450px-Naloxone.svg.png 2x" data-file-width="538" data-file-height="446" /></a></td></tr><tr><td colspan="2" class="infobox-image"><a href="/wiki/File:Naloxone-based-on-xtal-3D-bs-17.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Naloxone-based-on-xtal-3D-bs-17.png/250px-Naloxone-based-on-xtal-3D-bs-17.png" decoding="async" width="250" height="204" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Naloxone-based-on-xtal-3D-bs-17.png/375px-Naloxone-based-on-xtal-3D-bs-17.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Naloxone-based-on-xtal-3D-bs-17.png/500px-Naloxone-based-on-xtal-3D-bs-17.png 2x" data-file-width="2947" data-file-height="2405" /></a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Narcan, others</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Other names</th><td class="infobox-data">EN-1530; N-Allylnoroxymorphone; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one, naloxone hydrochloride (<a href="/wiki/United_States_Adopted_Name" title="United States Adopted Name">USAN</a> <abbr title="United States">US</abbr>)</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/naloxone-hydrochloride.html">Monograph</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a612022.html">a612022</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><abbr class="country-name" title="United States">US</abbr> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Naloxone">Naloxone</a></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pregnancy_category" title="Pregnancy category">Pregnancy category</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><abbr class="country-name" title="Australia">AU</abbr>: B1<a href="#cite_note-Drugs.com_pregnancy-1">[1]</a></li> <li class="mw-empty-elt"></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of administration</a></th><td class="infobox-data"><a href="/wiki/Nasal_administration" title="Nasal administration">Intranasal</a>, <a href="/wiki/Intravenous_therapy" title="Intravenous therapy">intravenous</a>, <a href="/wiki/Intramuscular" class="mw-redirect" title="Intramuscular">intramuscular</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_class" title="Drug class">Drug class</a></th><td class="infobox-data"><a href="/wiki/Opioid_antagonist" title="Opioid antagonist">Opioid antagonist</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a href="/wiki/ATC_code_A06" title="ATC code A06">A06AH04</a> (<a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=A06AH04">WHO</a>) <a href="/wiki/ATC_code_V03" title="ATC code V03">V03AB15</a> (<a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=V03AB15">WHO</a>)</li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"> <ul><li><abbr class="country-name" title="Australia">AU</abbr>: <a href="/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons#Schedule_4" title="Standard for the Uniform Scheduling of Medicines and Poisons">S4</a> (Prescription only) / S3 (Pharmacist Only Medicine)<a href="#cite_note-doi_10.5694/mja15.01181-2">[2]</a></li> <li><abbr class="country-name" title="Brazil">BR</abbr>: <a href="/wiki/Brazilian_Controlled_Drugs_and_Substances_Act#Class_C1" title="Brazilian Controlled Drugs and Substances Act">Class C1</a> (Other controlled substances)<a href="#cite_note-3">[3]</a></li> <li><abbr class="country-name" title="Canada">CA</abbr>: <a href="/wiki/Over-the-counter_drug" title="Over-the-counter drug">OTC</a><a href="#cite_note-4">[4]</a></li> <li><abbr class="country-name" title="Germany">DE</abbr>: § 48 <a href="/wiki/List_of_German_drug_laws#AMG" title="List of German drug laws">AMG</a>/§ 1 <a href="/wiki/List_of_German_drug_laws#MPAV" title="List of German drug laws">MPAV</a> (Prescription only)</li> <li><abbr class="country-name" title="United Kingdom">UK</abbr>: <a href="/wiki/Prescription_drug" title="Prescription drug">POM</a> (Prescription only)<a href="#cite_note-5">[5]</a></li> <li><abbr class="country-name" title="United States">US</abbr>: <a href="/wiki/Over-the-counter_drug" title="Over-the-counter drug">OTC</a> / Rx-only<a href="#cite_note-Narcan_FDA_label-6">[6]</a><a href="#cite_note-Evzio_FDA_label-7">[7]</a><a href="#cite_note-Zimhi_FDA_label-8">[8]</a><a href="#cite_note-Kloxxado_FDA_label-9">[9]</a><a href="#cite_note-10">[10]</a><a href="#cite_note-Rivive_FDA_label-11">[11]</a></li> <li>In general: ℞ (Prescription only)</li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;"><a href="/wiki/Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Bioavailability" title="Bioavailability">Bioavailability</a></th><td class="infobox-data">2% (<a href="/wiki/Oral_administration" title="Oral administration">by mouth</a>, 90% absorption but high <a href="/wiki/First-pass_metabolism" class="mw-redirect" title="First-pass metabolism">first-pass metabolism</a>) 43–54% (intranasal) 98% (intramuscular, subcutaneous)<a href="#cite_note-12">[12]</a><a href="#cite_note-AHFS2015-13">[13]</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_metabolism" title="Drug metabolism">Metabolism</a></th><td class="infobox-data"><a href="/wiki/Liver" title="Liver">Liver</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Onset_of_action" title="Onset of action">Onset of action</a></th><td class="infobox-data"><a href="/wiki/Intravenous_injection" class="mw-redirect" title="Intravenous injection"><abbr title="intravenous injection">IV</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip intravenous injection: 2 min, <a href="/wiki/Intramuscular_injection" title="Intramuscular injection"><abbr title="intramuscular injection">IM</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip intramuscular injection: 5 min<a href="#cite_note-AHFS2015-13">[13]</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Biological_half-life" title="Biological half-life">Elimination half-life</a></th><td class="infobox-data">1–1.5 h</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pharmacodynamics#Duration_of_action" title="Pharmacodynamics">Duration of action</a></th><td class="infobox-data"><a href="/wiki/Intranasal" class="mw-redirect" title="Intranasal"><abbr title="Intranasal">IN</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Intranasal: 30–90 min <a href="/wiki/Intravenous" class="mw-redirect" title="Intravenous"><abbr title="Intravenous">IV</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Intravenous: 45 min <a href="/wiki/Intramuscular" class="mw-redirect" title="Intramuscular"><abbr title="Intramuscular">IM</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Intramuscular: 30–120 min</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Excretion" title="Excretion">Excretion</a></th><td class="infobox-data"><a href="/wiki/Urine" title="Urine">Urine</a>, <a href="/wiki/Bile" title="Bile">bile</a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-(prop-2-en-1-yl)-2,3,4,4a,5,6-hexahydro-1H-4,12-methano[1]benzofurano[3,2-e]isoquinolin-7(7aH)-one</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=465-65-6">465-65-6</a> <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" />Y</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <abbr title="Compound ID">CID</abbr></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/5284596">5284596</a></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Guide_to_Pharmacology" title="Guide to Pharmacology">IUPHAR/BPS</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1638">1638</a></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB01183">DB01183</a> <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" />Y</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.4447644.html">4447644</a> <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" />Y</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/36B82AMQ7N">36B82AMQ7N</a></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D08249">D08249</a> <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" />Y</li><li>as HCl: <a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D01340">D01340</a> <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" />Y</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:7459">CHEBI:7459</a> <img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" />N</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL80">ChEMBL80</a> <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" />Y</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> (<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023349">DTXSID8023349</a> <a href="https://www.wikidata.org/wiki/Q282902#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard">ECHA InfoCard</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.006.697">100.006.697</a> <a href="https://www.wikidata.org/wiki/Q282902#P2566" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data">C19H21NO4</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data">327.380 g·mol−1</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409"><div class="plainlist"><ul><li><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=O%3DC1%5BC%40%40H%5D2OC3%3DC%28O%29C%3DCC4%3DC3%5BC%40%40%5D2%28%5BC%40%5D5%28CC1%29O%29CCN%28CC%3DC%29%5BC%40%40H%5D5C4">Interactive image</a></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">O=C1[C@@H]2OC3=C(O)C=CC4=C3[C@@]2([C@]5(CC1)O)CCN(CC=C)[C@@H]5C4</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1 <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" />Y</div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:UZHSEJADLWPNLE-GRGSLBFTSA-N <img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" />Y</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-below"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style> <img alt="☒" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/7px-X_mark.svg.png" decoding="async" width="7" height="8" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/11px-X_mark.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/X_mark.svg/14px-X_mark.svg.png 2x" data-file-width="525" data-file-height="600" />N<img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" />Y <a href="/wiki/Wikipedia:WikiProject_Chemicals/Chembox_validation" title="Wikipedia:WikiProject Chemicals/Chembox validation">(what is this?)</a><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r886047488">  <a class="external text" href="https://en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=440816974&page2=Naloxone">(verify)</a></td></tr></tbody></table> Naloxone, sold under the brand name Narcan among others, is an <a href="/wiki/Opioid_antagonist" title="Opioid antagonist">opioid antagonist</a>, a medication used to reverse or reduce the effects of <a href="/wiki/Opioids" class="mw-redirect" title="Opioids">opioids</a>.<a href="#cite_note-AHFS2015-13">[13]</a> For example, it is used to restore breathing after an <a href="/wiki/Opioid_overdose" title="Opioid overdose">opioid overdose</a>.<a href="#cite_note-AHFS2015-13">[13]</a> Effects begin within two minutes when given <a href="/wiki/Intravenous_therapy" title="Intravenous therapy">intravenously</a>, five minutes when <a href="/wiki/Intramuscular_injection" title="Intramuscular injection">injected into a muscle</a>,<a href="#cite_note-AHFS2015-13">[13]</a> and ten minutes as a <a href="/wiki/Nasal_spray" title="Nasal spray">nasal spray</a>.<a href="#cite_note-14">[14]</a> Naloxone blocks the effects of opioids for 30 to 90 minutes.<a href="#cite_note-15">[15]</a> Administration to opioid-dependent individuals may cause symptoms of <a href="/wiki/Opioid_withdrawal" title="Opioid withdrawal">opioid withdrawal</a>, including restlessness, agitation, nausea, vomiting, a <a href="/wiki/Tachycardia" title="Tachycardia">fast heart rate</a>, and sweating.<a href="#cite_note-AHFS2015-13">[13]</a> To prevent this, small doses every few minutes can be given until the desired effect is reached.<a href="#cite_note-AHFS2015-13">[13]</a> In those with previous heart disease or taking medications that negatively affect the heart, further heart problems have occurred.<a href="#cite_note-AHFS2015-13">[13]</a> It appears to be safe in pregnancy, after having been given to a limited number of women.<a href="#cite_note-TGA2014-16">[16]</a> Naloxone is a <a href="/wiki/Non-selective" class="mw-redirect" title="Non-selective">non-selective</a> and <a href="/wiki/Competitive_antagonist" class="mw-redirect" title="Competitive antagonist">competitive</a> <a href="/wiki/Opioid_receptor_antagonist" class="mw-redirect" title="Opioid receptor antagonist">opioid receptor antagonist</a>.<a href="#cite_note-Narcan_FDA_label-6">[6]</a><a href="#cite_note-NHM-Naloxone_pharmacology-17">[17]</a> It reverses the depression of the central nervous system and respiratory system caused by opioids.<a href="#cite_note-AHFS2015-13">[13]</a> Naloxone was patented in 1961 and approved for opioid overdose in the United States in 1971.<a href="#cite_note-nyti_Jack-18">[18]</a><a href="#cite_note-19">[19]</a> It is on the <a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">World Health Organization's List of Essential Medicines</a>.<a href="#cite_note-WHO21st-20">[20]</a> <style data-mw-deduplicate="TemplateStyles:r886046785">.mw-parser-output .toclimit-2 .toclevel-1 ul,.mw-parser-output .toclimit-3 .toclevel-2 ul,.mw-parser-output .toclimit-4 .toclevel-3 ul,.mw-parser-output .toclimit-5 .toclevel-4 ul,.mw-parser-output .toclimit-6 .toclevel-5 ul,.mw-parser-output .toclimit-7 .toclevel-6 ul{display:none}</style><div class="toclimit-3"><meta property="mw:PageProp/toc" /></div> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2>[<a href="/w/index.php?title=Naloxone&action=edit&section=1" title="Edit section: Medical uses">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Opioid_overdose">Opioid overdose</h3>[<a href="/w/index.php?title=Naloxone&action=edit&section=2" title="Edit section: Opioid overdose">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:NaloxoneKit.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d3/NaloxoneKit.jpg/220px-NaloxoneKit.jpg" decoding="async" width="220" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d3/NaloxoneKit.jpg/330px-NaloxoneKit.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d3/NaloxoneKit.jpg/440px-NaloxoneKit.jpg 2x" data-file-width="3964" data-file-height="3270" /></a><figcaption>A naloxone kit as distributed in British Columbia, Canada</figcaption></figure> Naloxone is useful in treating both acute <a href="/wiki/Opioid_overdose" title="Opioid overdose">opioid overdose</a> and respiratory or mental depression due to opioids.<a href="#cite_note-AHFS2015-13">[13]</a> Whether it is useful in those in <a href="/wiki/Cardiac_arrest" title="Cardiac arrest">cardiac arrest</a> due to an opioid overdose is unclear.<a href="#cite_note-special_circum_2015-21">[21]</a> It is included as a part of emergency overdose response kits distributed to <a href="/wiki/Heroin" title="Heroin">heroin</a>, <a href="/wiki/Fentanyl" title="Fentanyl">fentanyl</a>, and other opioid drug users, and to emergency responders. This has been shown to reduce rates of deaths due to overdose.<a href="#cite_note-pmid16956873-22">[22]</a> A prescription for naloxone is recommended if a person is on a high dose of opioid (>100 mg of <a href="/wiki/Morphine" title="Morphine">morphine</a> equivalence/day), is prescribed any dose of opioid accompanied by a <a href="/wiki/Benzodiazepine" title="Benzodiazepine">benzodiazepine</a>, or is suspected or known to use opioids nonmedically.<a href="#cite_note-23">[23]</a> Prescribing naloxone should be accompanied by standard education that includes preventing, identifying, and responding to an overdose; rescue breathing; and calling emergency services.<a href="#cite_note-pmid23664112-24">[24]</a> Distribution of naloxone to individuals likely to encounter people who overdose is one aspect of <a href="/wiki/Harm_reduction" title="Harm reduction">harm reduction</a> strategies.<a href="#cite_note-25">[25]</a> However, with opioids that have longer half-lives, respiratory depression returns after naloxone has worn off; therefore, adequate dosing and continuous monitoring may be necessary.<a href="#cite_note-26">[26]</a> <div class="mw-heading mw-heading3"><h3 id="Clonidine_overdose">Clonidine overdose</h3>[<a href="/w/index.php?title=Naloxone&action=edit&section=3" title="Edit section: Clonidine overdose">edit</a>]</div> Naloxone can also be used as an antidote in an overdose of <a href="/wiki/Clonidine" title="Clonidine">clonidine</a>, a medication that lowers blood pressure.<a href="#cite_note-27">[27]</a> Clonidine overdoses are of special relevance for children, in whom even small doses can cause significant harm.<a href="#cite_note-Ahmad_et_al_2015_Review-28">[28]</a> However, there is controversy regarding naloxone's efficacy in treating the symptoms of clonidine overdose, namely <a href="/wiki/Bradycardia" title="Bradycardia">slow heart rate</a>, <a href="/wiki/Hypotension" title="Hypotension">low blood pressure</a>, and <a href="/wiki/Altered_mental_status" class="mw-redirect" title="Altered mental status">confusion/somnolence</a>.<a href="#cite_note-Ahmad_et_al_2015_Review-28">[28]</a> Case reports that used doses of 0.1 mg/kg (maximum of 2 mg/dose) repeated every 1–2 minutes (10 mg total dose) have shown inconsistent benefit.<a href="#cite_note-Ahmad_et_al_2015_Review-28">[28]</a> As the doses used throughout the literature vary, it is difficult to form a conclusion regarding the benefit of naloxone in this setting.<a href="#cite_note-Seger_DL_Review-29">[29]</a> The mechanism for naloxone's proposed benefit in clonidine overdose is unclear. Still, it has been suggested that endogenous opioid receptors mediate the <a href="/wiki/Sympathetic_nervous_system" title="Sympathetic nervous system">sympathetic nervous system</a> in the brain and elsewhere in the body.<a href="#cite_note-Seger_DL_Review-29">[29]</a> <div class="mw-heading mw-heading3"><h3 id="Preventing_recreational_opioid_use">Preventing recreational opioid use</h3>[<a href="/w/index.php?title=Naloxone&action=edit&section=4" title="Edit section: Preventing recreational opioid use">edit</a>]</div> Naloxone is poorly absorbed when taken orally or sublingually, so it is often combined with several oral or sublingual opioid preparations, including <a href="/wiki/Buprenorphine/naloxone" title="Buprenorphine/naloxone">buprenorphine</a> and <a href="/wiki/Pentazocine" title="Pentazocine">pentazocine</a>, so that when swallowed or taken sublingually, only the non-naloxone opioid has an effect.<a href="#cite_note-AHFS2015-13">[13]</a><a href="#cite_note-Orman2009-30">[30]</a> However, if the combination is injected (such as by dissolving a pill or sublingual strip in water), the naloxone is believed to block the effect of the other opioid.<a href="#cite_note-AHFS2015-13">[13]</a><a href="#cite_note-Orman2009-30">[30]</a> This combination is used to prevent non-medical use.<a href="#cite_note-Orman2009-30">[30]</a> However, <a href="/wiki/SAMHSA" class="mw-redirect" title="SAMHSA">SAMHSA</a>'s clinical guidelines state that if the combination of buprenorphine and naloxone is injected by a regular user of buprenorphine or buprenorphine/naloxone, then the buprenorphine would still produce an agonist effect but the naloxone would fail to produce an antagonist effect. This is because the amount of naloxone that would be required to block the buprenorphine after injection is much larger than the amount that is contained in buprenorphine/naloxone (Suboxone) pills and strips.<a href="#cite_note-Guidelines_SAMHSA-31">[31]</a> If someone who is not physically dependent on opioids were to inject the buprenorphine/naloxone combination, then the effects of the buprenorphine may at most be slightly lessened, but the individual would still be expected to experience euphoric effects.<a href="#cite_note-Guidelines_SAMHSA-31">[31]</a> <div class="mw-heading mw-heading3"><h3 id="Other_uses">Other uses</h3>[<a href="/w/index.php?title=Naloxone&action=edit&section=5" title="Edit section: Other uses">edit</a>]</div> A 2003 meta-analysis of existing research showed naloxone to improve blood flow in patients with <a href="/wiki/Circulatory_shock" class="mw-redirect" title="Circulatory shock">shock</a>, including <a href="/wiki/Septic_shock" title="Septic shock">septic</a>, cardiogenic, hemorrhagic, or spinal shock, but could not determine if this reduced patient deaths.<a href="#cite_note-32">[32]</a> <div class="mw-heading mw-heading3"><h3 id="Special_populations">Special populations</h3>[<a href="/w/index.php?title=Naloxone&action=edit&section=6" title="Edit section: Special populations">edit</a>]</div> <div class="mw-heading mw-heading4"><h4 id="Pregnancy_and_breastfeeding">Pregnancy and breastfeeding</h4>[<a href="/w/index.php?title=Naloxone&action=edit&section=7" title="Edit section: Pregnancy and breastfeeding">edit</a>]</div> Whether naloxone is excreted in <a href="/wiki/Breast_milk" title="Breast milk">breast milk</a> is unknown, however, it is not <a href="/wiki/Bioavailability" title="Bioavailability">orally bioavailable</a> and therefore is unlikely to affect a <a href="/wiki/Breastfeeding" title="Breastfeeding">breastfeeding</a> infant.<a href="#cite_note-33">[33]</a> <div class="mw-heading mw-heading4"><h4 id="Children">Children</h4>[<a href="/w/index.php?title=Naloxone&action=edit&section=8" title="Edit section: Children">edit</a>]</div> Naloxone can be used on infants who were exposed to intrauterine opiates administered to mothers during delivery. However, there is insufficient evidence for the use of naloxone to lower cardiorespiratory and neurological depression in these infants.<a href="#cite_note-Naloxone_for_opioid-exposed_newborn-34">[34]</a> Infants exposed to high concentrations of opiates during pregnancy may have CNS damage in the setting of <a href="/wiki/Perinatal_asphyxia" title="Perinatal asphyxia">perinatal asphyxia</a>. Naloxone has been studied to improve outcomes in this population, however the evidence is currently weak.<a href="#cite_note-35">[35]</a><a href="#cite_note-Naloxone_for_opioid-exposed_newborn-34">[34]</a> Intravenous, intramuscular, or subcutaneous administration of naloxone can be given to children and neonates to reverse opiate effects. The <a href="/wiki/American_Academy_of_Pediatrics" title="American Academy of Pediatrics">American Academy of Pediatrics</a> recommends only intravenous administration as the other two forms can cause unpredictable absorption. After a dose is given, the child should be monitored for at least 24 hours. For children with low blood pressure due to <a href="/wiki/Septic_shock" title="Septic shock">septic shock</a>, naloxone safety and effectiveness are not established.<a href="#cite_note-36">[36]</a> <div class="mw-heading mw-heading4"><h4 id="Geriatric_use">Geriatric use</h4>[<a href="/w/index.php?title=Naloxone&action=edit&section=9" title="Edit section: Geriatric use">edit</a>]</div> For patients 65 years and older, it is unclear if there is a difference in response. However, older people often have decreased liver and kidney function which may lead to an increased level of naloxone in their body.<a href="#cite_note-Narcan_FDA_label-6">[6]</a> <div class="mw-heading mw-heading3"><h3 id="Available_forms">Available forms</h3>[<a href="/w/index.php?title=Naloxone&action=edit&section=10" title="Edit section: Available forms">edit</a>]</div> <div class="mw-heading mw-heading4"><h4 id="Intravenous">Intravenous</h4>[<a href="/w/index.php?title=Naloxone&action=edit&section=11" title="Edit section: Intravenous">edit</a>]</div> In hospital settings, naloxone is injected <a href="/wiki/Intravenously" class="mw-redirect" title="Intravenously">intravenously</a>, with an onset of 1–2 minutes and a duration of up to 45 minutes.<a href="#cite_note-Lexicomp._2013-37">[37]</a> <div class="mw-heading mw-heading4"><h4 id="Intramuscular_or_subcutaneous">Intramuscular or subcutaneous</h4>[<a href="/w/index.php?title=Naloxone&action=edit&section=12" title="Edit section: Intramuscular or subcutaneous">edit</a>]</div> Naloxone can also be administered via <a href="/wiki/Intramuscular" class="mw-redirect" title="Intramuscular">intramuscular</a> or <a href="/wiki/Subcutaneous_injection" class="mw-redirect" title="Subcutaneous injection">subcutaneous injection</a>. The onset of naloxone provided through this route is 2 to 5 minutes with a duration of around 30–120min.<a href="#cite_note-38">[38]</a> Naloxone administered intramuscularly are provided through pre-filled syringes, vials, and auto-injector. A hand-held auto-injector is pocket-sized and can be used in non-medical settings such as in the home.<a href="#cite_note-special_circum_2015-21">[21]</a> It is designed for use by laypersons, including family members and caregivers of opioid users at risk for an opioid emergency, such as an overdose.<a href="#cite_note-FDA_News_Release-39">[39]</a> According to the FDA's <a href="/wiki/National_Drug_Code" class="mw-redirect" title="National Drug Code">National Drug Code</a> Directory, a generic version of the auto-injector began to be marketed at the end of 2019.<a href="#cite_note-40">[40]</a> <div class="mw-heading mw-heading4"><h4 id="Intranasal">Intranasal</h4>[<a href="/w/index.php?title=Naloxone&action=edit&section=13" title="Edit section: Intranasal">edit</a>]</div> Narcan nasal spray was approved in the US in 2015 and is the first FDA-approved nasal spray for emergency treatment or suspected overdose.<a href="#cite_note-FDA_PR_20190419-41">[41]</a><a href="#cite_note-42">[42]</a> It was developed in a partnership between LightLake Therapeutics and the <a href="/wiki/National_Institute_on_Drug_Abuse" title="National Institute on Drug Abuse">National Institute on Drug Abuse</a>.<a href="#cite_note-43">[43]</a> The approval process was fast-tracked.<a href="#cite_note-44">[44]</a> A generic version of the nasal spray was approved in the United States in 2019, though did not come to market until 2021.<a href="#cite_note-FDA_PR_20190419-41">[41]</a><a href="#cite_note-Teva_Pharmaceuticals_2021-45">[45]</a> In 2021, the FDA approved Kloxxado, an 8 mg dose of intranasal naloxone developed by <a href="/wiki/Hikma_Pharmaceuticals" title="Hikma Pharmaceuticals">Hikma Pharmaceuticals</a>.<a href="#cite_note-46">[46]</a> Citing the frequent need for multiple 4 mg doses of Narcan to successfully reverse overdose, packs of Kloxxado Nasal Spray contain two pre-packaged nasal spray devices, each containing 8 mg of naloxone.<a href="#cite_note-47">[47]</a><a href="#cite_note-Kloxxado_FDA_label-9">[9]</a> However, a wedge device (nasal atomizer) can also be attached to a syringe that may also be used to create a mist to deliver the drug to the nasal <a href="/wiki/Mucosa" class="mw-redirect" title="Mucosa">mucosa</a>.<a href="#cite_note-pmid15039670-48">[48]</a> This is useful near facilities where many overdoses occur that already stock injectors.<a href="#cite_note-49">[49]</a> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:NARCAN_teardown.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/NARCAN_teardown.jpg/220px-NARCAN_teardown.jpg" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/NARCAN_teardown.jpg/330px-NARCAN_teardown.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/NARCAN_teardown.jpg/440px-NARCAN_teardown.jpg 2x" data-file-width="1917" data-file-height="1438" /></a><figcaption>Internal components of a naloxone nasal spray. </figcaption></figure> <div class="mw-heading mw-heading2"><h2 id="Side_effects">Side effects</h2>[<a href="/w/index.php?title=Naloxone&action=edit&section=14" title="Edit section: Side effects">edit</a>]</div> Administration of naloxone to somebody who has used opioids may cause rapid-onset <a href="/wiki/Opioid_withdrawal" title="Opioid withdrawal">opioid withdrawal</a>.<a href="#cite_note-britch-50">[50]</a> Naloxone has little to no effect if opioids are not present.<a href="#cite_note-51">[51]</a> In people with opioids in their system, it may cause increased sweating, nausea, restlessness, trembling, vomiting, flushing, and headache, and has in rare cases been associated with heart rhythm changes, <a href="/wiki/Seizures" class="mw-redirect" title="Seizures">seizures</a>, and <a href="/wiki/Pulmonary_edema" title="Pulmonary edema">pulmonary edema</a>.<a href="#cite_note-52">[52]</a><a href="#cite_note-pmid3662194-53">[53]</a> Naloxone has been shown to block the action of pain-lowering <a href="/wiki/Endorphin" class="mw-redirect" title="Endorphin">endorphins</a> the body produces naturally. These endorphins likely operate on the same opioid receptors that naloxone blocks. It is capable of blocking a <a href="/wiki/Placebo" title="Placebo">placebo</a> pain-lowering response if the placebo is administered together with a hidden or blind injection of naloxone.<a href="#cite_note-pmid15820838-54">[54]</a> Other studies have found that placebo alone can activate the body's μ-opioid endorphin system, delivering pain relief by the same receptor mechanism as morphine.<a href="#cite_note-55">[55]</a><a href="#cite_note-56">[56]</a> Naloxone should be used with caution in people with cardiovascular disease as well as those who are currently taking medications that could have adverse effects on the cardiovascular system such as causing <a href="/wiki/Hypotension" title="Hypotension">low blood pressure</a>, <a href="/wiki/Pulmonary_edema" title="Pulmonary edema">fluid accumulation in the lungs</a> (pulmonary edema), and <a href="/wiki/Arrhythmia" title="Arrhythmia">abnormal heart rhythms</a>. There have been reports of abrupt reversals with opioid antagonists leading to pulmonary edema and <a href="/wiki/Ventricular_fibrillation" title="Ventricular fibrillation">ventricular fibrillation</a>.<a href="#cite_note-uptodate_naloxone_contra-57">[57]</a> Use of naloxone to treat people who have been using opioids recreationally may cause acute <a href="/wiki/Opioid_withdrawal" title="Opioid withdrawal">opioid withdrawal</a> with distressing physiological symptoms such as shivering, <a href="/wiki/Tachycardia" title="Tachycardia">tachycardia</a>, and nausea; these in turn may lead to aggression and reluctance to receive further treatment.<a href="#cite_note-ukpg-58">[58]</a> <div class="mw-heading mw-heading2"><h2 id="Pharmacology">Pharmacology</h2>[<a href="/w/index.php?title=Naloxone&action=edit&section=15" title="Edit section: Pharmacology">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Pharmacodynamics">Pharmacodynamics</h3>[<a href="/w/index.php?title=Naloxone&action=edit&section=16" title="Edit section: Pharmacodynamics">edit</a>]</div> <table class="wikitable floatright" style="text-align: center;"> <caption>Naloxone at opioid receptors </caption> <tbody><tr> <th rowspan="2">Compound</th> <th colspan="3"><a href="/wiki/Binding_affinity" class="mw-redirect" title="Binding affinity">Affinities</a> (<a href="/wiki/Inhibitor_constant" class="mw-redirect" title="Inhibitor constant"><abbr title="Inhibitor constant">Ki</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Inhibitor constant)</th> <th>Ratios</th> <th rowspan="2">Refs </th></tr> <tr> <th><a href="/wiki/%CE%9C-Opioid_receptor" class="mw-redirect" title="Μ-Opioid receptor"><abbr title="μ-Opioid receptor">MOR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip μ-Opioid receptor</th> <th><a href="/wiki/%CE%94-Opioid_receptor" class="mw-redirect" title="Δ-Opioid receptor"><abbr title="δ-Opioid receptor">DOR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip δ-Opioid receptor</th> <th><a href="/wiki/%CE%9A-Opioid_receptor" class="mw-redirect" title="Κ-Opioid receptor"><abbr title="κ-Opioid receptor">KOR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip κ-Opioid receptor</th> <th>MOR:DOR:KOR </th></tr> <tr> <td>Naloxone</td> <td>1.1 nM 1.4 nM</td> <td>16 nM 67.5 nM</td> <td>12 nM 2.5 nM</td> <td>1:15:11 1:48:1.8</td> <td><a href="#cite_note-pmid2986989-59">[59]</a> <a href="#cite_note-pmid9686407-60">[60]</a><a href="#cite_note-pmid31376930-61">[61]</a> </td></tr> <tr> <td>(−)-Naloxone</td> <td>0.559 nM 0.93 nM</td> <td>36.5 nM 17 nM</td> <td>4.91 nM 2.3 nM</td> <td>1:65:9 1:18:2</td> <td><a href="#cite_note-pmid7562497-62">[62]</a> <a href="#cite_note-pmid8114680-63">[63]</a> </td></tr> <tr> <td>(+)-Naloxone</td> <td>3,550 nM >1,000 nM</td> <td>122,000 nM >1,000 nM</td> <td>8,950 nM >1,000 nM</td> <td>1:34:3 <abbr title="No data">ND</abbr></td> <td><a href="#cite_note-pmid7562497-62">[62]</a> <a href="#cite_note-pmid8114680-63">[63]</a> </td></tr></tbody></table> Naloxone is a <a href="/wiki/Lipophilic" class="mw-redirect" title="Lipophilic">lipophilic</a> compound that acts as a <a href="/wiki/Non-selective" class="mw-redirect" title="Non-selective">non-selective</a> and <a href="/wiki/Competitive_antagonist" class="mw-redirect" title="Competitive antagonist">competitive</a> <a href="/wiki/Opioid_receptor_antagonist" class="mw-redirect" title="Opioid receptor antagonist">opioid receptor antagonist</a>.<a href="#cite_note-NHM-Naloxone_pharmacology-17">[17]</a><a href="#cite_note-Narcan_FDA_label-6">[6]</a> The <a href="/wiki/Eudysmic_ratio" title="Eudysmic ratio">pharmacologically active isomer</a> of naloxone is (−)-naloxone.<a href="#cite_note-pmid7562497-62">[62]</a><a href="#cite_note-Naloxone_IUPHAR-64">[64]</a> Naloxone's <a href="/wiki/Binding_affinity" class="mw-redirect" title="Binding affinity">binding affinity</a> is highest for the <a href="/wiki/%CE%9C-opioid_receptor" title="Μ-opioid receptor">μ-opioid receptor</a> (MOR), then the <a href="/wiki/%CE%94-opioid_receptor" title="Δ-opioid receptor">δ-opioid receptor</a> (DOR), and lowest for the <a href="/wiki/%CE%9A-opioid_receptor" title="Κ-opioid receptor">κ-opioid receptor</a> (KOR);<a href="#cite_note-NHM-Naloxone_pharmacology-17">[17]</a> naloxone has negligible affinity for the <a href="/wiki/Nociceptin_receptor" title="Nociceptin receptor">nociceptin receptor</a>.<a href="#cite_note-Opioid_receptor_family_–_IUPHAR-65">[65]</a> If naloxone is administered in the absence of concomitant opioid use, no functional pharmacological activity occurs, except the inability of the body to combat pain naturally;<a href="#cite_note-Naloxone_effects_on_natural_analgesia-66">[66]</a> since pure mu-opioid antagonists like naloxone and <a href="/wiki/Naltrexone" title="Naltrexone">naltrexone</a> block the effects of <a href="/wiki/Endorphins" title="Endorphins">endorphins</a>.<a href="#cite_note-Opioid_antagonists_effects_on_endorphins-67">[67]</a><a href="#cite_note-Naloxone_Drug_Facts-68">[68]</a> In contrast to direct opiate agonists, which elicit opiate withdrawal symptoms when discontinued in opiate-tolerant people, no evidence indicates the development of tolerance or dependence on naloxone. The mechanism of action is not completely understood, but studies suggest it functions to produce withdrawal symptoms by competing for opioid receptors within the brain (a competitive antagonist, not a direct agonist), thereby preventing the action of both <a href="/wiki/Endogenous" class="mw-redirect" title="Endogenous">endogenous</a> and <a href="/wiki/Xenobiotic" title="Xenobiotic">xenobiotic</a> opioids on these receptors without directly producing any effects itself.<a href="#cite_note-DailyMed-69">[69]</a> A single administration of naloxone at a relatively high dose of 2 mg by <a href="/wiki/Intravenous_injection" class="mw-redirect" title="Intravenous injection">intravenous injection</a> has been found to produce brain MOR blockade of 80% at 5 minutes, 47% at 2 hours, 44% at 4 hours, and 8% at 8 hours.<a href="#cite_note-ColasantiLingford-HughesNutt2013-70">[70]</a> A low dose (2 μg/kg) produced brain MOR blockade of 42% at 5 minutes, 36% at 2 hours, 33% at 4 hours, and 10% at 8 hours.<a href="#cite_note-ColasantiLingford-HughesNutt2013-70">[70]</a> <a href="/wiki/Intranasal_administration" class="mw-redirect" title="Intranasal administration">Intranasal administration</a> of naloxone via <a href="/wiki/Nasal_spray" title="Nasal spray">nasal spray</a> has likewise been found to rapidly occupy brain MORs, with peak occupancy occurring at 20 minutes, peak occupancies of 67% at a dose of 2 mg and 85% with 4 mg, and an estimated half-life of occupancy disappearance of approximately 100 minutes (1.67 hours).<a href="#cite_note-van_WaardeAbsalomVisser2020-71">[71]</a><a href="#cite_note-pmid30867551-72">[72]</a> <div class="mw-heading mw-heading3"><h3 id="Pharmacokinetics">Pharmacokinetics</h3>[<a href="/w/index.php?title=Naloxone&action=edit&section=17" title="Edit section: Pharmacokinetics">edit</a>]</div> When administered <a href="https://en.wiktionary.org/wiki/parenteral" class="extiw" title="wikt:parenteral">parenterally</a> (non-orally or non-rectally, e.g., intravenously or by injection), as is most common, naloxone has a rapid distribution throughout the body. The mean serum half-life has been shown to range from 30 to 81 minutes, shorter than the average half-life of some opiates, necessitating repeat dosing if opioid receptors must be stopped from triggering for an extended period. Naloxone is primarily metabolized by the liver. Its major metabolite is naloxone-3-glucuronide, which is excreted in the urine.<a href="#cite_note-DailyMed-69">[69]</a> For people with liver diseases such as <a href="/wiki/Alcoholic_liver_disease" title="Alcoholic liver disease">alcoholic liver disease</a> or <a href="/wiki/Hepatitis" title="Hepatitis">hepatitis</a>, naloxone usage has not been shown to increase serum liver enzyme levels.<a href="#cite_note-73">[73]</a> Naloxone has low systemic bioavailability when <a href="/wiki/Oral_administration" title="Oral administration">taken by mouth</a> due to hepatic first-pass metabolism, but it does block opioid receptors that are located in the intestine.<a href="#cite_note-pmid10601678-74">[74]</a> <div class="mw-heading mw-heading2"><h2 id="Chemistry">Chemistry</h2>[<a href="/w/index.php?title=Naloxone&action=edit&section=18" title="Edit section: Chemistry">edit</a>]</div> Naloxone, also known as N-allylnoroxymorphone or as 17-allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one, is a <a href="/wiki/Synthetic_compound" class="mw-redirect" title="Synthetic compound">synthetic</a> <a href="/wiki/Morphinan" title="Morphinan">morphinan</a> <a href="/wiki/Chemical_derivative" class="mw-redirect" title="Chemical derivative">derivative</a> and was derived from <a href="/wiki/Oxymorphone" title="Oxymorphone">oxymorphone</a> (14-hydroxydihydromorphinone), an opioid analgesic.<a href="#cite_note-DeanBilsky2009-75">[75]</a><a href="#cite_note-Nagase2011-76">[76]</a><a href="#cite_note-NIST-77">[77]</a> Oxymorphone, in turn, was derived from <a href="/wiki/Morphine" title="Morphine">morphine</a>, an opioid analgesic and <a href="/wiki/Natural_product" title="Natural product">naturally occurring</a> constituent of the <a href="/wiki/Opium_poppy" class="mw-redirect" title="Opium poppy">opium poppy</a>.<a href="#cite_note-SeppalaRose2011-78">[78]</a> Naloxone is a <a href="/wiki/Racemic_mixture" title="Racemic mixture">racemic mixture</a> of two <a href="/wiki/Enantiomer" title="Enantiomer">enantiomers</a>, (–)-naloxone (levonaloxone) and <a href="/wiki/(%2B)-naloxone" class="mw-redirect" title="(+)-naloxone">(+)-naloxone</a> (dextronaloxone), only the former of which is active at opioid receptors.<a href="#cite_note-Bennett2006-79">[79]</a><a href="#cite_note-Wang2003-80">[80]</a> The drug is highly <a href="/wiki/Lipophilic" class="mw-redirect" title="Lipophilic">lipophilic</a>, allowing it to rapidly penetrate the brain and to achieve a far greater brain to serum ratio than that of morphine.<a href="#cite_note-DeanBilsky2009-75">[75]</a> Opioid antagonists related to naloxone include <a href="/wiki/Cyprodime" title="Cyprodime">cyprodime</a>, <a href="/wiki/Nalmefene" title="Nalmefene">nalmefene</a>, <a href="/wiki/Nalodeine" title="Nalodeine">nalodeine</a>, <a href="/wiki/Naloxol" title="Naloxol">naloxol</a>, and <a href="/wiki/Naltrexone" title="Naltrexone">naltrexone</a>.<a href="#cite_note-BruntonChabner2010-81">[81]</a> <div class="mw-heading mw-heading2"><h2 id="History">History</h2>[<a href="/w/index.php?title=Naloxone&action=edit&section=19" title="Edit section: History">edit</a>]</div> Naloxone was patented in 1961 by Mozes J. Lewenstein, <a href="/wiki/Jack_Fishman" title="Jack Fishman">Jack Fishman</a>, and the company <a href="/wiki/Daiichi_Sankyo" title="Daiichi Sankyo">Sankyo</a>.<a href="#cite_note-nyti_Jack-18">[18]</a> It was approved for opioid use disorder treatment in the United States in 1971.<a href="#cite_note-82">[82]</a> <div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2>[<a href="/w/index.php?title=Naloxone&action=edit&section=20" title="Edit section: Society and culture">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Misinformation">Misinformation</h3>[<a href="/w/index.php?title=Naloxone&action=edit&section=21" title="Edit section: Misinformation">edit</a>]</div> Naloxone has been subject to much inaccurate media reporting and many <a href="/wiki/Urban_legend" title="Urban legend">urban legends</a> about it have become prevalent.<a href="#cite_note-legends-83">[83]</a> One such myth is that naloxone makes the recipient violent.<a href="#cite_note-debunked-84">[84]</a> Another is that events called "Lazarus parties" have taken place, in which people reportedly took fatal overdoses in anticipation of being treated with naloxone; in reality this was a fiction spread by the police.<a href="#cite_note-legends-83">[83]</a> Yet another is the claim that people have indulged in "yo-yoing", whereby they would take naloxone and opioids simultaneously to enjoy an extreme "high" and subsequent revival; the idea is scientifically nonsensical.<a href="#cite_note-legends-83">[83]</a> <div class="mw-heading mw-heading3"><h3 id="Names">Names</h3>[<a href="/w/index.php?title=Naloxone&action=edit&section=22" title="Edit section: Names">edit</a>]</div> Naloxone is its <a href="/wiki/International_nonproprietary_name" title="International nonproprietary name">international nonproprietary name</a>, <a href="/wiki/British_Approved_Name" title="British Approved Name">British Approved Name</a>, <a href="/wiki/D%C3%A9nomination_Commune_Fran%C3%A7aise" title="Dénomination Commune Française">Dénomination Commune Française</a>, <a href="/wiki/Denominazione_Comune_Italiana" title="Denominazione Comune Italiana">Denominazione Comune Italiana</a>, and <a href="/wiki/Japanese_Accepted_Name" title="Japanese Accepted Name">Japanese Accepted Name</a>, while naloxone hydrochloride is its <a href="/wiki/United_States_Adopted_Name" title="United States Adopted Name">United States Adopted Name</a> and <a href="/wiki/British_Approved_Name" title="British Approved Name">British Approved Name (Modified)</a>.<a href="#cite_note-Elks2014-85">[85]</a><a href="#cite_note-IndexNominum2000-86">[86]</a><a href="#cite_note-MortonHall2012-87">[87]</a><a href="#cite_note-Drugs.com-88">[88]</a> The <a href="/wiki/Patent" title="Patent">patent</a> has expired and it is available as a <a href="/wiki/Generic_drug" title="Generic drug">generic medication</a>. Several formulations use patented dispensers (spray mechanisms or autoinjectors), and patent disputes over the generic forms of the nasal spray were litigated between 2016 and 2020 when a judge ruled in favor of Teva, the generic manufacturer.<a href="#cite_note-89">[89]</a> Teva announced entry of the first generic nasal spray formulation in December 2021.<a href="#cite_note-Teva_Pharmaceuticals_2021-45">[45]</a> Brand names of naloxone include Narcan, Kloxxado, Nalone, Evzio, Prenoxad Injection, Narcanti, Narcotan, and Zimhi, among others. <div class="mw-heading mw-heading3"><h3 id="Legal_status_and_availability_to_law_enforcement_and_emergency_personnel">Legal status and availability to law enforcement and emergency personnel</h3>[<a href="/w/index.php?title=Naloxone&action=edit&section=23" title="Edit section: Legal status and availability to law enforcement and emergency personnel">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1251242444"><table class="box-Globalize plainlinks metadata ambox ambox-content ambox-globalize" role="presentation"><tbody><tr><td class="mbox-image"><div class="mbox-image-div"><img alt="Globe icon." src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bd/Ambox_globe_content.svg/48px-Ambox_globe_content.svg.png" decoding="async" width="48" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bd/Ambox_globe_content.svg/73px-Ambox_globe_content.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bd/Ambox_globe_content.svg/97px-Ambox_globe_content.svg.png 2x" data-file-width="350" data-file-height="290" /></div></td><td class="mbox-text"><div class="mbox-text-span">The examples and perspective in this section deal primarily with the United States and Canada and do not represent a <a href="/wiki/Wikipedia:WikiProject_Countering_systemic_bias" title="Wikipedia:WikiProject Countering systemic bias">worldwide view</a> of the subject. You may <a class="external text" href="https://en.wikipedia.org/w/index.php?title=Naloxone&action=edit">improve this section</a>, discuss the issue on the <a href="/wiki/Talk:Naloxone#North-America-centric_legal_status_section" title="Talk:Naloxone">talk page</a>, or create a new section, as appropriate. (September 2022) (<a href="/wiki/Help:Maintenance_template_removal" title="Help:Maintenance template removal">Learn how and when to remove this message</a>)</div></td></tr></tbody></table> Naloxone (Nyxoid) was approved for use in the European Union in September 2017.<a href="#cite_note-Nyxoid_EPAR-90">[90]</a> In the United States, some nasal naloxone are legally available without a prescription.<a href="#cite_note-91">[91]</a><a href="#cite_note-92">[92]</a> As of 2019, officials in 29 states had issued standing orders to enable licensed pharmacists to provide naloxone to patients without the individual first visiting a prescriber.<a href="#cite_note-Network_for_Public_Health_Law-93">[93]</a> Prescribers working with harm reduction or low threshold treatment programs have also issued standing orders to enable these organizations to distribute naloxone to their clients.<a href="#cite_note-94">[94]</a> A standing order, also referred to as a "non-patient specific prescription" is written by a physician, nurse or other prescriber to authorize medicine distribution outside the doctor-patient relationship.<a href="#cite_note-95">[95]</a> In the case of naloxone, these orders are meant to facilitate naloxone distribution to people using opioids, and their family members and friends.<a href="#cite_note-Network_for_Public_Health_Law-93">[93]</a> Over 200 naloxone distribution programs utilize licensed prescribers to distribute the drug through such orders, or through the authority of pharmacists (as with California's legal provision, <a href="/wiki/AB1535" class="mw-redirect" title="AB1535">AB1535</a>).<a href="#cite_note-Beletsky_2009-96">[96]</a><a href="#cite_note-97">[97]</a> Laws and policies in many US jurisdictions have been changed to allow wider distribution of naloxone.<a href="#cite_note-98">[98]</a><a href="#cite_note-99">[99]</a> In addition to laws or regulations permitting distribution of medicine to at-risk individuals and families, some 36 states have passed laws that provide naloxone prescribers with immunity against both civil and criminal liabilities.<a href="#cite_note-100">[100]</a> While paramedics in the US have carried naloxone for decades, law enforcement officers in many states throughout the country carry naloxone to reverse the effects of heroin overdoses when reaching the location before paramedics. As of 12 July 2015, law enforcement departments in 28 US states are allowed to or required to carry naloxone to quickly respond to opioid overdoses.<a href="#cite_note-101">[101]</a> Programs training fire personnel in opioid overdose response using naloxone have also shown promise in the US, and efforts to integrate opioid fatality prevention into emergency response have grown due to the <a href="/wiki/Opioid_epidemic_in_the_United_States" title="Opioid epidemic in the United States">US overdose crisis</a>.<a href="#cite_note-Beletsky_2012-102">[102]</a><a href="#cite_note-103">[103]</a><a href="#cite_note-pmid19602236-104">[104]</a><a href="#cite_note-105">[105]</a> Following the use of the nasal spray device by police officers on Staten Island in New York, an additional 20,000 police officers will begin carrying naloxone in mid-2014. The state's Office of the Attorney General will provide US$1.2 million to supply nearly 20,000 kits. Police Commissioner <a href="/wiki/William_Bratton" title="William Bratton">William Bratton</a> said: "Naloxone gives individuals a second chance to get help".<a href="#cite_note-106">[106]</a> <a href="/wiki/Emergency_medical_services_in_the_United_Kingdom" title="Emergency medical services in the United Kingdom">Emergency Medical Service</a> Providers (EMS) routinely administer naloxone, except where basic Emergency Medical Technicians are prohibited by policy or by state law.<a href="#cite_note-107">[107]</a> In efforts to encourage citizens to seek help for possible opioid overdoses, many states have adopted Good Samaritan laws that provide immunity against certain criminal liabilities for anybody who, in good faith, seeks emergency medical care for either themselves or someone around them who may be experiencing an opioid overdose.<a href="#cite_note-108">[108]</a> States including Vermont and Virginia have developed programs that mandate the prescription of naloxone when a prescription has exceeded a certain level of morphine <a href="/wiki/Equivalent_(chemistry)" title="Equivalent (chemistry)">milliequivalents</a> per day as preventative measures against overdose.<a href="#cite_note-109">[109]</a> Healthcare institution-based naloxone prescription programs have also helped reduce rates of opioid overdose in <a href="/wiki/North_Carolina" title="North Carolina">North Carolina</a>, and have been replicated in the US military.<a href="#cite_note-Beletsky_2009-96">[96]</a><a href="#cite_note-pmid21668761-110">[110]</a> In Canada, naloxone single-use syringe kits are distributed and available at various clinics and emergency rooms. <a href="/wiki/Alberta_Health_Services" title="Alberta Health Services">Alberta Health Services</a> is increasing the distribution points for naloxone kits at all emergency rooms, and various pharmacies and clinics province-wide. All <a href="/wiki/Edmonton_Police_Service" title="Edmonton Police Service">Edmonton Police Service</a> and <a href="/wiki/Calgary_Police_Service" title="Calgary Police Service">Calgary Police Service</a> patrol cars carry an emergency single-use naloxone syringe kit. Some <a href="/wiki/Royal_Canadian_Mounted_Police" title="Royal Canadian Mounted Police">Royal Canadian Mounted Police</a> patrol vehicles also carry the drug, occasionally in excess to help distribute naloxone among users and concerned family/friends. Nurses, paramedics, medical technicians, and emergency medical responders can also prescribe and distribute the drug. As of February 2016, pharmacies across <a href="/wiki/Alberta" title="Alberta">Alberta</a> and some other Canadian jurisdictions are allowed to distribute single-use take-home naloxone kits or prescribe the drug to people using opioids.<a href="#cite_note-cbc.ca-111">[111]</a> Following Alberta Health Services, <a href="/wiki/Health_Canada" title="Health Canada">Health Canada</a> reviewed the prescription-only status of naloxone, resulting in plans to remove it in 2016, making naloxone more accessible.<a href="#cite_note-112">[112]</a><a href="#cite_note-113">[113]</a> Due to the rising number of drug deaths across the country, Health Canada proposed a change to make naloxone more widely available to Canadians in support of efforts to address the growing number of opioid overdoses.<a href="#cite_note-114">[114]</a> In March 2016, Health Canada did change the prescription status of naloxone, as "pharmacies are now able to proactively give out naloxone to those who might experience or witness an opioid overdose."<a href="#cite_note-115">[115]</a> <div class="mw-heading mw-heading3"><h3 id="Community_access">Community access</h3>[<a href="/w/index.php?title=Naloxone&action=edit&section=24" title="Edit section: Community access">edit</a>]</div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Mendocino_Pride_2023_-_Sarah_Stierch_-_12.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7b/Mendocino_Pride_2023_-_Sarah_Stierch_-_12.jpg/220px-Mendocino_Pride_2023_-_Sarah_Stierch_-_12.jpg" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7b/Mendocino_Pride_2023_-_Sarah_Stierch_-_12.jpg/330px-Mendocino_Pride_2023_-_Sarah_Stierch_-_12.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7b/Mendocino_Pride_2023_-_Sarah_Stierch_-_12.jpg/440px-Mendocino_Pride_2023_-_Sarah_Stierch_-_12.jpg 2x" data-file-width="4031" data-file-height="3023" /></a><figcaption>Free Narcan and test strips at a community event in <a href="/wiki/Hopland,_California" title="Hopland, California">Hopland, California</a>.</figcaption></figure>In a survey of US laypersons in December 2021, most people believed the scientifically supported idea that trained bystanders can reverse overdoses with naloxone.<a href="#cite_note-116">[116]</a> A survey of US naloxone prescription programs in 2010 revealed that 21 out of 48 programs reported challenges in obtaining naloxone in the months leading up to the survey, due mainly to either cost increases that outstripped allocated funding or the suppliers' inability to fill orders.<a href="#cite_note-cdc.gov-117">[117]</a> The approximate cost of a 1 ml ampoule of naloxone in the US is estimated to be significantly higher than in most other countries.<a href="#cite_note-Beletsky_2009-96">[96]</a> <a href="/wiki/Take-home_naloxone_program" title="Take-home naloxone program">Take-home naloxone programs</a> for people who use opioids is underway in many North American cities.<a href="#cite_note-cdc.gov-117">[117]</a><a href="#cite_note-118">[118]</a> CDC estimates that the US programs for drug users and their caregivers prescribing take-home doses of naloxone and training on its use prevented 10,000 opioid overdose deaths by 2014.<a href="#cite_note-cdc.gov-117">[117]</a> In Australia, some forms of naloxone are available "over the counter" in pharmacies free without a prescription under the Take Home Naloxone programme. <a href="#cite_note-doi_10.5694/mja15.01181-2">[2]</a><a href="#cite_note-119">[119]</a><a href="#cite_note-120">[120]</a> It comes in single-use filled syringe form similar to law enforcement kits as well as nasal sprays. In 2024, those with a prescription can purchase five doses for around AU$32 or just over AU$6 per dose.<a href="#cite_note-121">[121]</a><a href="#cite_note-122">[122]</a> In Alberta, in addition to pharmacy distribution, take-home naloxone kits are available and distributed in most drug treatment or rehabilitation centers.<a href="#cite_note-cbc.ca-111">[111]</a> In the European Union, take home naloxone pilots were launched in the Channel Islands and in Berlin in the late 1990s.<a href="#cite_note-123">[123]</a> In 2008, the Welsh Assembly government announced its intention to establish demonstration sites for take-home naloxone,<a href="#cite_note-124">[124]</a> and in 2010, Scotland instituted a national naloxone program.<a href="#cite_note-125">[125]</a> Inspired by North American and European efforts, non-governmental organizations running programs to train drug users as overdose responders and supply them with naloxone are now operational in Russia, Ukraine, Georgia, Kazakhstan, Tajikistan, Afghanistan, China, Vietnam, and Thailand.<a href="#cite_note-126">[126]</a> In 2018, a maker[<a href="/wiki/Wikipedia:Avoid_weasel_words" class="mw-redirect" title="Wikipedia:Avoid weasel words">which?</a>] of naloxone announced it would provide a free kit including two doses of the nasal spray, as well as educational materials, to each of the 16,568 public libraries and 2,700 YMCAs in the U.S.<a href="#cite_note-127">[127]</a> <div class="mw-heading mw-heading2"><h2 id="References">References</h2>[<a href="/w/index.php?title=Naloxone&action=edit&section=25" title="Edit section: References">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output 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.id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a 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The Medical Journal of Australia. 204 (4): 146–147. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.5694%2Fmja15.01181">10.5694/mja15.01181</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26937664">26937664</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:9320372">9320372</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200719232637/https://www.mja.com.au/journal/2016/204/4/australia-reschedules-naloxone-opioid-overdose">Archived</a> from the original on 19 July 2020. 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Drugs: Education, Prevention and Policy. 19 (4): 309–319. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3109%2F09687637.2012.682232">10.3109/09687637.2012.682232</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0968-7637">0968-7637</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:73263293">73263293</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20230309063059/https://www.tandfonline.com/doi/full/10.3109/09687637.2012.682232?cookieSet=1">Archived</a> from the original on 9 March 2023. Retrieved 6 January 2022.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drugs%3A+Education%2C+Prevention+and+Policy&rft.atitle=From+evidence+to+policy%3A+The+Scottish+national+naloxone+programme&rft.volume=19&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E309-%3C%2Fspan%3E319&rft.date=2012-08-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A73263293%23id-name%3DS2CID&rft.issn=0968-7637&rft_id=info%3Adoi%2F10.3109%2F09687637.2012.682232&rft.aulast=McAuley&rft.aufirst=A&rft.au=Best%2C+D&rft.au=Taylor%2C+A&rft.au=Hunter%2C+C&rft.au=Robertson%2C+R&rft_id=https%3A%2F%2Fdoi.org%2F10.3109%2F09687637.2012.682232&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANaloxone" class="Z3988"> </li> <li id="cite_note-126"><a href="#cite_ref-126">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.opensocietyfoundations.org/publications/stopping-overdose">"Stopping Overdose"</a>. Open Society Foundations. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20220107035410/https://www.opensocietyfoundations.org/publications/stopping-overdose">Archived</a> from the original on 7 January 2022. Retrieved 6 January 2022.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Stopping+Overdose&rft.pub=Open+Society+Foundations&rft_id=https%3A%2F%2Fwww.opensocietyfoundations.org%2Fpublications%2Fstopping-overdose&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANaloxone" class="Z3988"> </li> <li id="cite_note-127"><a href="#cite_ref-127">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation magazine cs1"><a rel="nofollow" class="external text" href="https://time.com/5432950/narcan-libraries-ymca/">"Every U.S. Public Library and YMCA Will Soon Get Narcan for Free"</a>. Time. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20190401224345/http://time.com/5432950/narcan-libraries-ymca/">Archived</a> from the original on 1 April 2019. Retrieved 2 April 2019.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Time&rft.atitle=Every+U.S.+Public+Library+and+YMCA+Will+Soon+Get+Narcan+for+Free&rft_id=https%3A%2F%2Ftime.com%2F5432950%2Fnarcan-libraries-ymca%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANaloxone" class="Z3988"> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2>[<a href="/w/index.php?title=Naloxone&action=edit&section=26" title="Edit section: Further reading">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation book cs1"><a rel="nofollow" class="external text" href="http://www.inchem.org/documents/antidote/antidote/ant01.htm">Naloxone, Flumazenil and Dantrolene as Antidotes</a>. IPCS/CEC Evaluation of Antidotes Series. Vol. 1. Cambridge University Press. 1993. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/0-521-45459-X" title="Special:BookSources/0-521-45459-X"><bdi>0-521-45459-X</bdi></a>. EUR 14797 EN. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20031215213521/http://inchem.org/documents/antidote/antidote/ant01.htm">Archived</a> from the original on 15 December 2003. Retrieved 15 February 2004.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Naloxone%2C+Flumazenil+and+Dantrolene+as+Antidotes&rft.series=IPCS%2FCEC+Evaluation+of+Antidotes+Series&rft.pub=Cambridge+University+Press&rft.date=1993&rft.isbn=0-521-45459-X&rft_id=http%3A%2F%2Fwww.inchem.org%2Fdocuments%2Fantidote%2Fantidote%2Fant01.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANaloxone" class="Z3988"></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2>[<a href="/w/index.php?title=Naloxone&action=edit&section=27" title="Edit section: External links">edit</a>]</div> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a616003.html">"Naloxone Nasal Spray"</a>. <a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Naloxone+Nasal+Spray&rft.pub=MedlinePlus&rft_id=https%3A%2F%2Fmedlineplus.gov%2Fdruginfo%2Fmeds%2Fa616003.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANaloxone" class="Z3988"></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.samhsa.gov/medications-substance-use-disorders/medications-counseling-related-conditions/opioid-overdose-reversal-medications">"Opioid Overdose Reversal Medications (OORM)"</a>. U.S. <a href="/wiki/Substance_Abuse_and_Mental_Health_Services_Administration" title="Substance Abuse and Mental Health Services Administration">Substance Abuse and Mental Health Services Administration</a> (SAMHSA. 26 March 2024.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Substance+Abuse+and+Mental+Health+Services+Administration+%28SAMHSA&rft.atitle=Opioid+Overdose+Reversal+Medications+%28OORM%29&rft.date=2024-03-26&rft_id=https%3A%2F%2Fwww.samhsa.gov%2Fmedications-substance-use-disorders%2Fmedications-counseling-related-conditions%2Fopioid-overdose-reversal-medications&rfr_id=info%3Asid%2Fen.wikipedia.org%3ANaloxone" class="Z3988"></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist 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style="width:1%"><a href="/wiki/Benzodiazepine_overdose" title="Benzodiazepine overdose">Benzodiazepine overdose</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cyprodenate" title="Cyprodenate">Cyprodenate</a></li> <li><a href="/wiki/Flumazenil" title="Flumazenil">Flumazenil</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/GHB_overdose" class="mw-redirect" title="GHB overdose">GHB overdose</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Physostigmine" title="Physostigmine">Physostigmine</a></li> <li><a href="/wiki/SCH-50911" title="SCH-50911">SCH-50911</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nerve_agent" title="Nerve agent">Nerve agent</a> / <a href="/wiki/Organophosphate_poisoning" title="Organophosphate poisoning">Organophosphate poisoning</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Atropine" title="Atropine">Atropine</a>#</li> <li><a href="/wiki/Biperiden" title="Biperiden">Biperiden</a></li> <li><a href="/wiki/Diazepam" title="Diazepam">Diazepam</a>#</li> <li><a href="/wiki/Oxime" title="Oxime">Oximes</a> <ul><li><a href="/wiki/Obidoxime" title="Obidoxime">Obidoxime</a></li> <li><a href="/wiki/Pralidoxime" title="Pralidoxime">Pralidoxime</a></li></ul></li> <li>see also: <a href="/wiki/Cholinesterase" title="Cholinesterase">Cholinesterase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Opioid_overdose" title="Opioid overdose">Opioid overdose</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Diprenorphine" title="Diprenorphine">Diprenorphine</a></li> <li><a href="/wiki/Doxapram" title="Doxapram">Doxapram</a></li> <li><a href="/wiki/Nalmefene" title="Nalmefene">Nalmefene</a></li> <li><a href="/wiki/Nalorphine" title="Nalorphine">Nalorphine</a></li> <li><a class="mw-selflink selflink">Naloxone</a>#</li> <li><a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Reversal of <a href="/wiki/Neuromuscular-blocking_drug" title="Neuromuscular-blocking drug">neuromuscular blockade</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sugammadex" title="Sugammadex">Sugammadex</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Circulatory_system" title="Circulatory system">Circulatory system</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Beta_blocker#Adverse_effects" title="Beta blocker">Beta blocker</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Glucagon" title="Glucagon">Glucagon</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Digoxin_toxicity" title="Digoxin toxicity">Digoxin toxicity</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Digoxin_immune_fab" title="Digoxin immune fab">Digoxin immune fab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Anticoagulant" title="Anticoagulant">Anticoagulants</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>against <a href="/wiki/Direct_Xa_inhibitor" class="mw-redirect" title="Direct Xa inhibitor">direct Xa inhibitors</a> (<a href="/wiki/Andexanet_alfa" title="Andexanet alfa">Andexanet alfa</a>)</li> <li>against <a href="/wiki/Heparin" title="Heparin">heparin</a> (<a href="/wiki/Protamine_sulfate" title="Protamine sulfate">Protamine</a>#)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Arsenic_poisoning" title="Arsenic poisoning">Arsenic poisoning</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Dimercaprol" title="Dimercaprol">Dimercaprol</a>#</li> <li><a href="/wiki/Dimercaptosuccinic_acid" class="mw-redirect" title="Dimercaptosuccinic acid">Succimer</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cyanide_poisoning" title="Cyanide poisoning">Cyanide poisoning</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/4-Dimethylaminophenol" title="4-Dimethylaminophenol">4-Dimethylaminophenol</a></li> <li><a href="/wiki/Hydroxocobalamin" title="Hydroxocobalamin">Hydroxocobalamin</a></li> <li><a href="/wiki/Nitrite" title="Nitrite">nitrite</a> <ul><li><a href="/wiki/Amyl_nitrite" title="Amyl nitrite">Amyl nitrite</a></li> <li><a href="/wiki/Sodium_nitrite" title="Sodium nitrite">Sodium nitrite</a>#</li></ul></li> <li><a href="/wiki/Sodium_thiosulfate_(medical_use)" title="Sodium thiosulfate (medical use)">Sodium thiosulfate</a>#</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hydrofluoric_acid" title="Hydrofluoric acid">Hydrofluoric acid</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcium_gluconate" title="Calcium gluconate">Calcium gluconate</a>#</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Methanol" title="Methanol">Methanol</a> / <a href="/wiki/Ethylene_glycol_poisoning" title="Ethylene glycol poisoning">Ethylene glycol poisoning</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Primary alcohols: <a href="/wiki/Alcohol_(medicine)" class="mw-redirect" title="Alcohol (medicine)">Ethanol</a></li> <li><a href="/wiki/Fomepizole" title="Fomepizole">Fomepizole</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Paracetamol_poisoning" title="Paracetamol poisoning">Paracetamol toxicity</a> (Acetaminophen)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acetylcysteine" title="Acetylcysteine">Acetylcysteine</a>#</li> <li><a href="/wiki/Glutathione" title="Glutathione">Glutathione</a></li> <li><a href="/wiki/Methionine" title="Methionine">Methionine</a>#</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Toxic_metal" class="mw-redirect" title="Toxic metal">Toxic metals</a> (<a href="/wiki/Cadmium_poisoning" title="Cadmium poisoning">cadmium</a> <ul><li><a href="/wiki/Lead_poisoning" title="Lead poisoning">lead</a></li> <li><a href="/wiki/Mercury_poisoning" title="Mercury poisoning">mercury</a></li> <li><a href="/wiki/Thallium_poisoning" title="Thallium poisoning">thallium</a>)</li></ul></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <li><a href="/wiki/Dimercaprol" title="Dimercaprol">Dimercaprol</a>#</li> <li><a href="/wiki/Ethylenediaminetetraacetic_acid" title="Ethylenediaminetetraacetic acid">Edetates</a></li> <li><a href="/wiki/Prussian_blue" title="Prussian blue">Prussian blue</a>#</li> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Iodine-131" title="Iodine-131">iodine-131</a> <ul><li><a href="/wiki/Potassium_iodide" title="Potassium iodide">Potassium iodide</a></li></ul></li> <li><a href="/wiki/Methylene_blue" title="Methylene blue">Methylthioninium chloride</a>#</li> <li><a href="/wiki/Oxidizing_agent" title="Oxidizing agent">oxidizing agent</a> <ul><li><a href="/wiki/Potassium_permanganate" title="Potassium permanganate">Potassium permanganate</a></li></ul></li> <li><a href="/wiki/Prednisolone/promethazine" title="Prednisolone/promethazine">Prednisolone/promethazine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Emetic" class="mw-redirect" title="Emetic">Emetic</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Copper(II)_sulfate" title="Copper(II) sulfate">Copper sulfate</a></li> <li><a href="/wiki/Psychotria_ipecacuanha" class="mw-redirect" title="Psychotria ipecacuanha">Ipecacuanha</a> <ul><li><a href="/wiki/Syrup_of_ipecac" title="Syrup of ipecac">Syrup of ipecac</a></li></ul></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background: transparent; padding: 0px;"><div><div class="hlist"> <ul><li>#<a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li>‡<a href="/wiki/List_of_withdrawn_drugs" title="List of withdrawn drugs">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li>†<a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li>§Never to phase III</li></ul></li></ul> </div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Opioid_receptor_modulators225" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Opioid_receptor_modulators" title="Template:Opioid receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Opioid_receptor_modulators" title="Template talk:Opioid receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Opioid_receptor_modulators" title="Special:EditPage/Template:Opioid receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Opioid_receptor_modulators225" style="font-size:114%;margin:0 4em"><a href="/wiki/Opioid_receptor" title="Opioid receptor">Opioid receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/%CE%9C-opioid_receptor" title="Μ-opioid receptor">μ-opioid</a> (MOR)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Agonists(abridged;full_list)67" scope="row" class="navbox-group" style="width:1%">Agonists (abridged; <a href="/wiki/List_of_opioids" title="List of opioids">full list</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/3-HO-PCP" title="3-HO-PCP">3-HO-PCP</a></li> <li><a href="/w/index.php?title=7-Acetoxymitragynine&action=edit&redlink=1" class="new" title="7-Acetoxymitragynine (page does not exist)">7-Acetoxymitragynine</a></li> <li><a href="/wiki/7-Hydroxymitragynine" title="7-Hydroxymitragynine">7-Hydroxymitragynine</a></li> <li><a href="/w/index.php?title=%CE%A8-Akuammigine&action=edit&redlink=1" class="new" title="Ψ-Akuammigine (page does not exist)">ψ-Akuammigine</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">α-Chlornaltrexamine</a></li> <li><a href="/w/index.php?title=Alpha-Narcotine&action=edit&redlink=1" class="new" title="Alpha-Narcotine (page does not exist)">α-Narcotine</a></li> <li><a href="/wiki/Acetyldihydrocodeine" title="Acetyldihydrocodeine">Acetyldihydrocodeine</a></li> <li><a href="/wiki/Acetylfentanyl" title="Acetylfentanyl">Acetylfentanyl</a></li> <li><a href="/wiki/Acrylfentanyl" title="Acrylfentanyl">Acrylfentanyl</a></li> <li><a href="/wiki/Adrenorphin" title="Adrenorphin">Adrenorphin (metorphamide)</a></li> <li><a href="/wiki/AH-7921" title="AH-7921">AH-7921</a></li> <li><a href="/wiki/Akuammicine" title="Akuammicine">Akuammicine</a></li> <li><a href="/w/index.php?title=Akuammidine&action=edit&redlink=1" class="new" title="Akuammidine (page does not exist)">Akuammidine</a></li> <li><a href="/wiki/Alfentanil" title="Alfentanil">Alfentanil</a></li> <li><a href="/wiki/Anileridine" title="Anileridine">Anileridine</a></li> <li><a href="/wiki/Apparicine" title="Apparicine">Apparicine</a></li> <li><a href="/wiki/Beta-Endorphin" class="mw-redirect" title="Beta-Endorphin">β-Endorphin</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-12P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-12P (page does not exist)">BAM-12P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-18P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-18P (page does not exist)">BAM-18P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-22P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-22P (page does not exist)">BAM-22P</a></li> <li><a href="/wiki/Benzhydrocodone" title="Benzhydrocodone">Benzhydrocodone</a></li> <li><a href="/wiki/Benzylmorphine" title="Benzylmorphine">Benzylmorphine</a></li> <li><a href="/wiki/Bezitramide" title="Bezitramide">Bezitramide</a></li> <li><a href="/wiki/Biphalin" title="Biphalin">Biphalin</a></li> <li><a href="/w/index.php?title=BU08070&action=edit&redlink=1" class="new" title="BU08070 (page does not exist)">BU08070</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Butorphan" class="mw-redirect" title="Butorphan">Butorphan</a></li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/Butyrfentanyl" title="Butyrfentanyl">Butyrfentanyl</a></li> <li><a href="/wiki/BW373U86" title="BW373U86">BW373U86</a></li> <li><a href="/wiki/Carfentanil" title="Carfentanil">Carfentanil</a></li> <li><a href="/wiki/Casokefamide" title="Casokefamide">Casokefamide</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Chloroxymorphamine" title="Chloroxymorphamine">Chloroxymorphamine</a></li> <li><a href="/wiki/Codeine" title="Codeine">Codeine</a></li> <li><a href="/wiki/DADLE" title="DADLE">DADLE</a></li> <li><a href="/wiki/DAMGO" title="DAMGO">DAMGO (DAGO)</a></li> <li><a href="/wiki/Dermorphin" title="Dermorphin">Dermorphin</a></li> <li><a href="/wiki/Desmetramadol" title="Desmetramadol">Desmetramadol</a> (desmethyltramadol)</li> <li><a href="/wiki/Desomorphine" title="Desomorphine">Desomorphine</a></li> <li><a href="/wiki/Dextromoramide" title="Dextromoramide">Dextromoramide</a></li> <li><a href="/wiki/Dextropropoxyphene" title="Dextropropoxyphene">Dextropropoxyphene</a> (propoxyphene)</li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/wiki/Dimenoxadol" title="Dimenoxadol">Dimenoxadol</a></li> <li><a href="/wiki/Dimethylaminopivalophenone" title="Dimethylaminopivalophenone">Dimethylaminopivalophenone</a></li> <li><a href="/wiki/Eluxadoline" title="Eluxadoline">Eluxadoline</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine</a> (heroin)</li> <li><a href="/wiki/Dihydrocodeine" title="Dihydrocodeine">Dihydrocodeine</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/Dinalbuphine_sebacate" title="Dinalbuphine sebacate">Dinalbuphine sebacate</a></li> <li><a href="/wiki/Diphenoxylate" title="Diphenoxylate">Diphenoxylate</a></li> <li><a href="/wiki/Dipipanone" title="Dipipanone">Dipipanone</a></li> <li><a href="/wiki/Dynorphin_A" title="Dynorphin A">Dynorphin A</a></li> <li><a href="/wiki/Embutramide" title="Embutramide">Embutramide</a></li> <li><a href="/wiki/Endomorphin-1" title="Endomorphin-1">Endomorphin-1</a></li> <li><a href="/wiki/Endomorphin-2" title="Endomorphin-2">Endomorphin-2</a></li> <li><a href="/wiki/Eseroline" title="Eseroline">Eseroline</a></li> <li><a href="/wiki/Ethylmorphine" title="Ethylmorphine">Ethylmorphine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a></li> <li><a href="/wiki/Fluorophen" title="Fluorophen">Fluorophen</a></li> <li><a href="/wiki/Frakefamide" title="Frakefamide">Frakefamide</a></li> <li><a href="/wiki/Furanylfentanyl" title="Furanylfentanyl">Furanylfentanyl</a></li> <li><a href="/wiki/Hemorphin-4" title="Hemorphin-4">Hemorphin-4</a></li> <li><a href="/wiki/Herkinorin" title="Herkinorin">Herkinorin</a></li> <li><a href="/wiki/Hodgkinsine" title="Hodgkinsine">Hodgkinsine</a></li> <li><a href="/wiki/Hydrocodone" title="Hydrocodone">Hydrocodone</a></li> <li><a href="/wiki/Hydromorphinol" title="Hydromorphinol">Hydromorphinol</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/IBNtxA" title="IBNtxA">IBNtxA</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/Ketobemidone" title="Ketobemidone">Ketobemidone</a></li> <li><a href="/wiki/Mitragyna_speciosa" title="Mitragyna speciosa">Kratom</a></li> <li><a href="/wiki/Laudanosine" title="Laudanosine">Laudanosine</a></li> <li><a href="/wiki/Lefetamine" title="Lefetamine">Lefetamine</a></li> <li><a href="/wiki/Leu-enkephalin" title="Leu-enkephalin">Leu-enkephalin</a></li> <li><a href="/wiki/Levacetylmethadol" title="Levacetylmethadol">Levacetylmethadol</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/Loperamide" title="Loperamide">Loperamide</a></li> <li><a href="/wiki/Loxicodegol" class="mw-redirect" title="Loxicodegol">Loxicodegol</a></li> <li><a href="/wiki/LS-115509" title="LS-115509">LS-115509</a></li> <li><a href="/wiki/Matrine" title="Matrine">Matrine</a></li> <li><a href="/wiki/Meptazinol" title="Meptazinol">Meptazinol</a></li> <li><a href="/wiki/Met-enkephalin" title="Met-enkephalin">Met-enkephalin</a> (metenkefalin)</li> <li><a href="/wiki/Methadone" title="Methadone">Methadone</a></li> <li><a href="/wiki/Metkefamide" title="Metkefamide">Metkefamide</a></li> <li><a href="/wiki/Metopon" title="Metopon">Metopon</a></li> <li><a href="/wiki/Mitragynine" title="Mitragynine">Mitragynine</a></li> <li><a href="/wiki/Mitragynine_pseudoindoxyl" title="Mitragynine pseudoindoxyl">Mitragynine pseudoindoxyl</a></li> <li><a href="/wiki/Morphiceptin" title="Morphiceptin">Morphiceptin</a></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a></li> <li><a href="/wiki/Nalbuphine" title="Nalbuphine">Nalbuphine</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">Naloxone benzoylhydrazone</a> (NalBzOH)</li> <li><a href="/wiki/Nalmexone" title="Nalmexone">Nalmexone</a></li> <li><a href="/wiki/Naltalimide" title="Naltalimide">Naltalimide</a></li> <li><a href="/w/index.php?title=Neopine&action=edit&redlink=1" class="new" title="Neopine (page does not exist)">Neopine</a></li> <li><a href="/wiki/NFEPP" title="NFEPP">NFEPP</a></li> <li><a href="/wiki/Nicocodeine" title="Nicocodeine">Nicocodeine</a></li> <li><a href="/wiki/Nicodicodine" title="Nicodicodine">Nicodicodine</a></li> <li><a href="/wiki/Nicomorphine" title="Nicomorphine">Nicomorphine</a></li> <li><a href="/wiki/Norketamine" title="Norketamine">Norketamine</a></li> <li><a href="/wiki/Nufenoxole" title="Nufenoxole">Nufenoxole</a></li> <li><a href="/wiki/Octreotide" title="Octreotide">Octreotide</a></li> <li><a href="/wiki/Oliceridine" title="Oliceridine">Oliceridine</a></li> <li><a href="/wiki/Oxycodegol" title="Oxycodegol">Oxycodegol</a></li> <li><a href="/wiki/Oxymorphone-3-methoxynaltrexonazine" title="Oxymorphone-3-methoxynaltrexonazine">Oxymorphone-3-methoxynaltrexonazine</a> (OM-3-MNZ)</li> <li><a href="/wiki/Oripavine" title="Oripavine">Oripavine</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a></li> <li><a href="/wiki/Oxymorphazone" title="Oxymorphazone">Oxymorphazone</a></li> <li><a href="/w/index.php?title=Oxymorphonazine&action=edit&redlink=1" class="new" title="Oxymorphonazine (page does not exist)">Oxymorphonazine</a></li> <li><a href="/wiki/Oxymorphone" title="Oxymorphone">Oxymorphone</a></li> <li><a href="/w/index.php?title=Oxymorphone_phenylhydrazone&action=edit&redlink=1" class="new" title="Oxymorphone phenylhydrazone (page does not exist)">Oxymorphone phenylhydrazone</a></li> <li><a href="/w/index.php?title=Oxymorphone_p-nitrophenylhydrazone&action=edit&redlink=1" class="new" title="Oxymorphone p-nitrophenylhydrazone (page does not exist)">OxyPNPH</a></li> <li><a href="/wiki/Papaver_somniferum" title="Papaver somniferum">Papaver somniferum</a> (<a href="/wiki/Opium" title="Opium">opium</a>)</li> <li><a href="/wiki/Pentazocine" title="Pentazocine">Pentazocine</a></li> <li><a href="/wiki/Pericine" title="Pericine">Pericine</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Phenazocine" title="Phenazocine">Phenazocine</a></li> <li><a href="/wiki/Phencyclidine" title="Phencyclidine">Phencyclidine</a></li> <li><a href="/wiki/Piminodine" title="Piminodine">Piminodine</a></li> <li><a href="/wiki/Piritramide" title="Piritramide">Piritramide</a></li> <li><a href="/w/index.php?title=PL-017&action=edit&redlink=1" class="new" title="PL-017 (page does not exist)">PL-017</a></li> <li><a href="/wiki/Prodine" title="Prodine">Prodine</a></li> <li><a href="/wiki/Propiram" title="Propiram">Propiram</a></li> <li><a href="/wiki/PZM21" title="PZM21">PZM21</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/Remifentanil" title="Remifentanil">Remifentanil</a></li> <li><a href="/wiki/Salsolinol" title="Salsolinol">Salsolinol</a></li> <li><a href="/wiki/SC-17599" title="SC-17599">SC-17599</a></li> <li><a href="/wiki/Sinomenine" title="Sinomenine">Sinomenine</a></li> <li><a href="/wiki/Sufentanil" title="Sufentanil">Sufentanil</a></li> <li><a href="/wiki/Tapentadol" title="Tapentadol">Tapentadol</a></li> <li><a href="/wiki/Tetrahydropapaveroline" title="Tetrahydropapaveroline">Tetrahydropapaveroline</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li> <li><a href="/wiki/Thebaine" title="Thebaine">Thebaine</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li> <li><a href="/wiki/Tianeptine" title="Tianeptine">Tianeptine</a></li> <li><a href="/wiki/Tilidine" title="Tilidine">Tilidine</a></li> <li><a href="/wiki/Tramadol" title="Tramadol">Tramadol</a></li> <li><a href="/wiki/Trimebutine" title="Trimebutine">Trimebutine</a></li> <li><a href="/wiki/TRIMU_5" title="TRIMU 5">TRIMU 5</a></li> <li><a href="/wiki/TRV734" title="TRV734">TRV734</a></li> <li><a href="/w/index.php?title=Tubotaiwine&action=edit&redlink=1" class="new" title="Tubotaiwine (page does not exist)">Tubotaiwine</a></li> <li><a href="/wiki/U-47700" title="U-47700">U-47700</a></li> <li><a href="/wiki/Valorphin" title="Valorphin">Valorphin</a></li> <li><a href="/wiki/Viminol" title="Viminol">Viminol</a></li> <li><a href="/wiki/Xorphanol" title="Xorphanol">Xorphanol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Picenadol" title="Picenadol">(3S,4S)-Picenadol</a></li> <li><a href="/wiki/Viminol" title="Viminol">2-(S)-N,N-(R)-Viminol</a></li> <li><a href="/w/index.php?title=3CS-nalmefene&action=edit&redlink=1" class="new" title="3CS-nalmefene (page does not exist)">3CS-nalmefene</a></li> <li><a href="/wiki/4-Caffeoyl-1,5-quinide" title="4-Caffeoyl-1,5-quinide">4-Caffeoyl-1,5-quinide</a></li> <li><a href="/wiki/4%E2%80%B2-Hydroxyflavanone" class="mw-redirect" title="4′-Hydroxyflavanone">4′-Hydroxyflavanone</a></li> <li><a href="/wiki/4%27,7-Dihydroxyflavone" title="4',7-Dihydroxyflavone">4',7-Dihydroxyflavone</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol" title="6β-Naltrexol">6β-Naltrexol</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol-d4" title="6β-Naltrexol-d4">6β-Naltrexol-d4</a></li> <li><a href="/wiki/18-Methoxycoronaridine" title="18-Methoxycoronaridine">18-MC</a></li> <li><a href="/wiki/Alpha-Gliadin" class="mw-redirect" title="Alpha-Gliadin">α-Gliadin</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Beta-Funaltrexamine" class="mw-redirect" title="Beta-Funaltrexamine">β-Funaltrexamine</a></li> <li><a href="/wiki/Akuammine" title="Akuammine">Akuammine</a></li> <li><a href="/wiki/Alvimopan" title="Alvimopan">Alvimopan</a></li> <li><a href="/wiki/AM-251_(drug)" title="AM-251 (drug)">AM-251</a></li> <li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/wiki/Axelopran" title="Axelopran">Axelopran</a></li> <li><a href="/wiki/Bevenopran" title="Bevenopran">Bevenopran</a></li> <li><a href="/wiki/Catechin" title="Catechin">Catechin</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">Catechin gallate</a></li> <li><a href="/wiki/Clocinnamox" title="Clocinnamox">Clocinnamox</a></li> <li>CTAP</li> <li><a href="/w/index.php?title=CTOP&action=edit&redlink=1" class="new" title="CTOP (page does not exist)">CTOP</a></li> <li><a href="/w/index.php?title=Cyclofoxy&action=edit&redlink=1" class="new" title="Cyclofoxy (page does not exist)">Cyclofoxy</a></li> <li><a href="/wiki/Cyprodime" title="Cyprodime">Cyprodime</a></li> <li><a href="/wiki/Diacetylnalorphine" title="Diacetylnalorphine">Diacetylnalorphine</a></li> <li><a href="/wiki/Diprenorphine" title="Diprenorphine">Diprenorphine</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a></li> <li><a href="/wiki/Gallocatechol" title="Gallocatechol">EGC</a></li> <li><a href="/wiki/Epicatechin" class="mw-redirect" title="Epicatechin">Epicatechin</a></li> <li><a href="/wiki/Eptazocine" title="Eptazocine">Eptazocine</a></li> <li><a href="/wiki/Gemazocine" title="Gemazocine">Gemazocine</a></li> <li><a href="/w/index.php?title=Ginsenoside_R&action=edit&redlink=1" class="new" title="Ginsenoside R (page does not exist)">Ginsenoside R</a></li> <li><a href="/wiki/Hyperoside" title="Hyperoside">Hyperoside</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/JDTic" title="JDTic">JDTic</a></li> <li><a href="/wiki/Levallorphan" title="Levallorphan">Levallorphan</a></li> <li><a href="/wiki/Lobeline" title="Lobeline">Lobeline</a></li> <li><a href="/wiki/LY-255582" title="LY-255582">LY-255582</a></li> <li><a href="/wiki/LY-2196044" class="mw-redirect" title="LY-2196044">LY-2196044</a></li> <li><a href="/wiki/Methocinnamox" title="Methocinnamox">Methocinnamox</a></li> <li><a href="/wiki/Methylnaltrexone" title="Methylnaltrexone">Methylnaltrexone</a></li> <li><a href="/w/index.php?title=Methylsamidorphan_chloride&action=edit&redlink=1" class="new" title="Methylsamidorphan chloride (page does not exist)">Methylsamidorphan chloride</a></li> <li><a href="/wiki/Naldemedine" title="Naldemedine">Naldemedine</a></li> <li><a href="/wiki/Nalmefene" title="Nalmefene">Nalmefene</a></li> <li><a href="/wiki/Nalodeine" title="Nalodeine">Nalodeine (N-allylnorcodeine)</a></li> <li><a href="/wiki/Nalorphine" title="Nalorphine">Nalorphine</a></li> <li><a href="/wiki/Nalorphine_dinicotinate" title="Nalorphine dinicotinate">Nalorphine dinicotinate</a></li> <li><a href="/wiki/Naloxazone" title="Naloxazone">Naloxazone</a></li> <li><a href="/wiki/Naloxegol" title="Naloxegol">Naloxegol</a></li> <li><a href="/wiki/Naloxol" title="Naloxol">Naloxol</a></li> <li><a href="/wiki/Naloxonazine" title="Naloxonazine">Naloxonazine</a></li> <li><a class="mw-selflink selflink">Naloxone</a></li> <li><a href="/w/index.php?title=Naltrexazone&action=edit&redlink=1" class="new" title="Naltrexazone (page does not exist)">Naltrexazone</a></li> <li><a href="/w/index.php?title=Naltrexonazine&action=edit&redlink=1" class="new" title="Naltrexonazine (page does not exist)">Naltrexonazine</a></li> <li><a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a></li> <li><a href="/wiki/Naltrindole" title="Naltrindole">Naltrindole</a></li> <li><a href="/wiki/Naringenin" title="Naringenin">Naringenin</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Oxilorphan" title="Oxilorphan">Oxilorphan</a></li> <li><a href="/wiki/Pawhuskin_A" title="Pawhuskin A">Pawhuskin A</a></li> <li><a href="/wiki/Rimonabant" title="Rimonabant">Rimonabant</a></li> <li><a href="/wiki/Quadazocine" title="Quadazocine">Quadazocine</a></li> <li><a href="/wiki/Samidorphan" title="Samidorphan">Samidorphan</a></li> <li><a href="/wiki/Taxifolin" title="Taxifolin">Taxifolin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/%CE%94-opioid_receptor" title="Δ-opioid receptor">δ-opioid</a> (DOR)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=3CS-nalmefene&action=edit&redlink=1" class="new" title="3CS-nalmefene (page does not exist)">3CS-nalmefene</a></li> <li><a href="/wiki/6%27-Guanidinonaltrindole" title="6'-Guanidinonaltrindole">6'-GNTI</a></li> <li><a href="/wiki/7-Spiroindanyloxymorphone" title="7-Spiroindanyloxymorphone">7-SIOM</a></li> <li><a href="/wiki/ADL-5747" title="ADL-5747">ADL-5747 (PF-04856881)</a></li> <li><a href="/wiki/ADL-5859" title="ADL-5859">ADL-5859</a></li> <li><a href="/wiki/Alazocine" title="Alazocine">Alazocine (SKF-10047)</a></li> <li><a href="/wiki/Amoxapine" title="Amoxapine">Amoxapine</a></li> <li><a href="/wiki/ARM390" title="ARM390">AR-M100390 (ARM390)</a></li> <li><a href="/wiki/AZD2327" class="mw-redirect" title="AZD2327">AZD2327</a></li> <li><a href="/wiki/Beta-Endorphin" class="mw-redirect" title="Beta-Endorphin">β-Endorphin</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-18P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-18P (page does not exist)">BAM-18P</a></li> <li><a href="/wiki/Biphalin" title="Biphalin">Biphalin</a></li> <li><a href="/wiki/BU-48" title="BU-48">BU-48</a></li> <li><a href="/wiki/Butorphan" class="mw-redirect" title="Butorphan">Butorphan</a></li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/BW373U86" title="BW373U86">BW373U86</a></li> <li><a href="/wiki/Casokefamide" title="Casokefamide">Casokefamide</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Codeine" title="Codeine">Codeine</a></li> <li><a href="/wiki/Cyclazocine" title="Cyclazocine">Cyclazocine</a></li> <li><a href="/wiki/DADLE" title="DADLE">DADLE</a></li> <li><a href="/wiki/Deltorphin" title="Deltorphin">Deltorphin A</a></li> <li><a href="/wiki/Deltorphin_I" title="Deltorphin I">Deltorphin I</a></li> <li><a href="/w/index.php?title=Deltorphin_II&action=edit&redlink=1" class="new" title="Deltorphin II (page does not exist)">Deltorphin II</a></li> <li><a href="/wiki/Desmethylclozapine" title="Desmethylclozapine">Desmethylclozapine</a></li> <li><a href="/wiki/Desmetramadol" title="Desmetramadol">Desmetramadol (desmethyltramadol)</a></li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine (heroin)</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/DPDPE" title="DPDPE">DPDPE</a></li> <li><a href="/wiki/DPI-221" title="DPI-221">DPI-221</a></li> <li><a href="/wiki/DPI-3290" title="DPI-3290">DPI-3290</a></li> <li><a href="/w/index.php?title=(D-Ser2,_Leu5,_Thr6)-Enkephalin&action=edit&redlink=1" class="new" title="(D-Ser2, Leu5, Thr6)-Enkephalin (page does not exist)">DSLET</a></li> <li><a href="/wiki/Ethylketazocine" title="Ethylketazocine">Ethylketazocine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a></li> <li><a href="/w/index.php?title=Fentanyl_isothiocyanate&action=edit&redlink=1" class="new" title="Fentanyl isothiocyanate (page does not exist)">FIT</a></li> <li><a href="/wiki/Fluorophen" title="Fluorophen">Fluorophen</a></li> <li><a href="/wiki/Hemorphin-4" title="Hemorphin-4">Hemorphin-4</a></li> <li><a href="/wiki/Hydrocodone" title="Hydrocodone">Hydrocodone</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/Isomethadone" title="Isomethadone">Isomethadone</a></li> <li><a href="/wiki/JNJ-20788560" title="JNJ-20788560">JNJ-20788560</a></li> <li><a href="/wiki/KNT-127" title="KNT-127">KNT-127</a></li> <li><a href="/wiki/Mitragyna_speciosa" title="Mitragyna speciosa">Kratom</a></li> <li><a href="/wiki/Laudanosine" title="Laudanosine">Laudanosine</a></li> <li><a href="/wiki/Leu-enkephalin" title="Leu-enkephalin">Leu-enkephalin</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/Lofentanil" title="Lofentanil">Lofentanil</a></li> <li><a href="/wiki/Met-enkephalin" title="Met-enkephalin">Met-enkephalin (metenkefalin)</a></li> <li><a href="/wiki/Metazocine" title="Metazocine">Metazocine</a></li> <li><a href="/wiki/Metkefamide" title="Metkefamide">Metkefamide</a></li> <li><a href="/wiki/Mitragynine" title="Mitragynine">Mitragynine</a></li> <li><a href="/wiki/Mitragynine_pseudoindoxyl" title="Mitragynine pseudoindoxyl">Mitragynine pseudoindoxyl</a></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a></li> <li><a href="/wiki/N-Phenethyl-14-ethoxymetopon" title="N-Phenethyl-14-ethoxymetopon">N-Phenethyl-14-ethoxymetopon</a></li> <li><a href="/wiki/Norbuprenorphine" title="Norbuprenorphine">Norbuprenorphine</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/wiki/Oripavine" title="Oripavine">Oripavine</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a></li> <li><a href="/wiki/Oxymorphone" title="Oxymorphone">Oxymorphone</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Proglumide" title="Proglumide">Proglumide</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/RWJ-394674" title="RWJ-394674">RWJ-394674</a></li> <li><a href="/wiki/Samidorphan" title="Samidorphan">Samidorphan</a></li> <li><a href="/w/index.php?title=SB-235863&action=edit&redlink=1" class="new" title="SB-235863 (page does not exist)">SB-235863</a></li> <li><a href="/wiki/SNC-80" title="SNC-80">SNC-80</a></li> <li><a href="/w/index.php?title=SNC-162&action=edit&redlink=1" class="new" title="SNC-162 (page does not exist)">SNC-162</a></li> <li><a href="/wiki/TAN-67" title="TAN-67">TAN-67 (SB-205,607)</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li> <li><a href="/wiki/Thebaine" title="Thebaine">Thebaine</a></li> <li><a href="/wiki/C-8813" title="C-8813">Thiobromadol (C-8813)</a></li> <li><a href="/wiki/Tonazocine" title="Tonazocine">Tonazocine</a></li> <li><a href="/wiki/Tramadol" title="Tramadol">Tramadol</a></li> <li><a href="/w/index.php?title=TRV250&action=edit&redlink=1" class="new" title="TRV250 (page does not exist)">TRV250</a></li> <li><a href="/wiki/Xorphanol" title="Xorphanol">Xorphanol</a></li> <li><a href="/wiki/Zenazocine" title="Zenazocine">Zenazocine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/4%27,7-Dihydroxyflavone" title="4',7-Dihydroxyflavone">4',7-Dihydroxyflavone</a></li> <li><a href="/w/index.php?title=Naltrindole-5%27-isothiocyanate&action=edit&redlink=1" class="new" title="Naltrindole-5'-isothiocyanate (page does not exist)">5'-NTII</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol" title="6β-Naltrexol">6β-Naltrexol</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol-d4" title="6β-Naltrexol-d4">6β-Naltrexol-d4</a></li> <li><a href="/w/index.php?title=Alpha-Santolol&action=edit&redlink=1" class="new" title="Alpha-Santolol (page does not exist)">α-Santolol</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/wiki/Axelopran" title="Axelopran">Axelopran</a></li> <li><a href="/wiki/Bevenopran" title="Bevenopran">Bevenopran</a></li> <li><a href="/w/index.php?title=7-Benzylidenenaltrexone&action=edit&redlink=1" class="new" title="7-Benzylidenenaltrexone (page does not exist)">BNTX</a></li> <li><a href="/wiki/Catechin" title="Catechin">Catechin</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">Catechin gallate</a></li> <li><a href="/wiki/Clocinnamox" title="Clocinnamox">Clocinnamox</a></li> <li><a href="/wiki/Diacetylnalorphine" title="Diacetylnalorphine">Diacetylnalorphine</a></li> <li><a href="/wiki/Diprenorphine" title="Diprenorphine">Diprenorphine</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a></li> <li><a href="/wiki/Gallocatechol" title="Gallocatechol">EGC</a></li> <li><a href="/wiki/Eluxadoline" title="Eluxadoline">Eluxadoline</a></li> <li><a href="/wiki/Epicatechin" class="mw-redirect" title="Epicatechin">Epicatechin</a></li> <li><a href="/w/index.php?title=ICI-154129&action=edit&redlink=1" class="new" title="ICI-154129 (page does not exist)">ICI-154129</a></li> <li><a href="/w/index.php?title=ICI-174864&action=edit&redlink=1" class="new" title="ICI-174864 (page does not exist)">ICI-174864</a></li> <li><a href="/wiki/LY-255582" title="LY-255582">LY-255582</a></li> <li><a href="/wiki/LY-2196044" class="mw-redirect" title="LY-2196044">LY-2196044</a></li> <li><a href="/wiki/Methylnaltrexone" title="Methylnaltrexone">Methylnaltrexone</a></li> <li><a href="/w/index.php?title=Methylnaltrindole&action=edit&redlink=1" class="new" title="Methylnaltrindole (page does not exist)">Methylnaltrindole</a></li> <li><a href="/w/index.php?title=N-Benzylnaltrindole&action=edit&redlink=1" class="new" title="N-Benzylnaltrindole (page does not exist)">N-Benzylnaltrindole</a></li> <li><a href="/wiki/Nalmefene" title="Nalmefene">Nalmefene</a></li> <li><a href="/wiki/Nalorphine" title="Nalorphine">Nalorphine</a></li> <li><a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a></li> <li><a href="/wiki/Naltriben" title="Naltriben">Naltriben</a></li> <li><a href="/wiki/Naltrindole" title="Naltrindole">Naltrindole</a></li> <li><a class="mw-selflink selflink">Naloxone</a></li> <li><a href="/wiki/Naringenin" title="Naringenin">Naringenin</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Pawhuskin_A" title="Pawhuskin A">Pawhuskin A</a></li> <li><a href="/wiki/Quadazocine" title="Quadazocine">Quadazocine</a></li> <li><a href="/w/index.php?title=SDM25N&action=edit&redlink=1" class="new" title="SDM25N (page does not exist)">SDM25N</a></li> <li><a href="/wiki/SoRI-9409" title="SoRI-9409">SoRI-9409</a></li> <li><a href="/wiki/Taxifolin" title="Taxifolin">Taxifolin</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/%CE%9A-opioid_receptor" title="Κ-opioid receptor">κ-opioid</a> (KOR)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=3CS-nalmefene&action=edit&redlink=1" class="new" title="3CS-nalmefene (page does not exist)">3CS-nalmefene</a></li> <li><a href="/wiki/6%27-Guanidinonaltrindole" title="6'-Guanidinonaltrindole">6'-GNTI</a></li> <li><a href="/wiki/8-Carboxamidocyclazocine" title="8-Carboxamidocyclazocine">8-CAC</a></li> <li><a href="/wiki/18-Methoxycoronaridine" title="18-Methoxycoronaridine">18-MC</a></li> <li><a href="/wiki/14-Methoxymetopon" title="14-Methoxymetopon">14-Methoxymetopon</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Beta-Funaltrexamine" class="mw-redirect" title="Beta-Funaltrexamine">β-Funaltrexamine</a></li> <li><a href="/wiki/Adrenorphin" title="Adrenorphin">Adrenorphin (metorphamide)</a></li> <li><a href="/wiki/Akuammicine" title="Akuammicine">Akuammicine</a></li> <li><a href="/wiki/Alazocine" title="Alazocine">Alazocine (SKF-10047)</a></li> <li><a href="/wiki/Allomatrine" class="mw-redirect" title="Allomatrine">Allomatrine</a></li> <li><a href="/w/index.php?title=Apadoline&action=edit&redlink=1" class="new" title="Apadoline (page does not exist)">Apadoline</a></li> <li><a href="/wiki/Asimadoline" title="Asimadoline">Asimadoline</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-12P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-12P (page does not exist)">BAM-12P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-18P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-18P (page does not exist)">BAM-18P</a></li> <li><a href="/w/index.php?title=Bovine_adrenal_medullary_peptide-22P&action=edit&redlink=1" class="new" title="Bovine adrenal medullary peptide-22P (page does not exist)">BAM-22P</a></li> <li><a href="/wiki/Big_dynorphin" title="Big dynorphin">Big dynorphin</a></li> <li><a href="/wiki/Bremazocine" title="Bremazocine">Bremazocine</a></li> <li><a href="/wiki/BRL-52537" title="BRL-52537">BRL-52537</a></li> <li><a href="/wiki/Butorphan" class="mw-redirect" title="Butorphan">Butorphan</a></li> <li><a href="/wiki/Butorphanol" title="Butorphanol">Butorphanol</a></li> <li><a href="/wiki/BW373U86" title="BW373U86">BW373U86</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Ciprefadol" title="Ciprefadol">Ciprefadol</a></li> <li><a href="/wiki/CR665" title="CR665">CR665</a></li> <li><a href="/wiki/Cyclazocine" title="Cyclazocine">Cyclazocine</a></li> <li><a href="/wiki/Cyclorphan" title="Cyclorphan">Cyclorphan</a></li> <li><a href="/wiki/Cyprenorphine" title="Cyprenorphine">Cyprenorphine</a></li> <li><a href="/wiki/Desmetramadol" title="Desmetramadol">Desmetramadol (desmethyltramadol)</a></li> <li><a href="/wiki/Heroin" title="Heroin">Diamorphine (heroin)</a></li> <li><a href="/wiki/Diacetylnalorphine" title="Diacetylnalorphine">Diacetylnalorphine</a></li> <li><a href="/wiki/Difelikefalin" title="Difelikefalin">Difelikefalin</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Dihydromorphine" title="Dihydromorphine">Dihydromorphine</a></li> <li><a href="/wiki/Dinalbuphine_sebacate" title="Dinalbuphine sebacate">Dinalbuphine sebacate</a></li> <li><a href="/wiki/Diprenorphine" title="Diprenorphine">Diprenorphine</a></li> <li><a href="/wiki/Dynorphin_A" title="Dynorphin A">Dynorphin A</a></li> <li><a href="/wiki/Dynorphin_B" title="Dynorphin B">Dynorphin B (rimorphin)</a></li> <li><a href="/wiki/Eluxadoline" title="Eluxadoline">Eluxadoline</a></li> <li><a href="/wiki/Enadoline" title="Enadoline">Enadoline</a></li> <li><a href="/wiki/Eptazocine" title="Eptazocine">Eptazocine</a></li> <li><a href="/w/index.php?title=Erinacine_E&action=edit&redlink=1" class="new" title="Erinacine E (page does not exist)">Erinacine E</a></li> <li><a href="/wiki/Ethylketazocine" title="Ethylketazocine">Ethylketazocine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/wiki/Fedotozine" title="Fedotozine">Fedotozine</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a></li> <li><a href="/wiki/Gemazocine" title="Gemazocine">Gemazocine</a></li> <li><a href="/wiki/GR-89696" title="GR-89696">GR-89696</a></li> <li><a href="/w/index.php?title=GR-103545&action=edit&redlink=1" class="new" title="GR-103545 (page does not exist)">GR-103545</a></li> <li><a href="/wiki/Hemorphin-4" title="Hemorphin-4">Hemorphin-4</a></li> <li><a href="/wiki/Herkinorin" title="Herkinorin">Herkinorin</a></li> <li><a href="/wiki/HS665" title="HS665">HS665</a></li> <li><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a></li> <li><a href="/wiki/HZ-2" title="HZ-2">HZ-2</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/ICI-199,441" title="ICI-199,441">ICI-199,441</a></li> <li><a href="/wiki/ICI-204,448" title="ICI-204,448">ICI-204,448</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/Ketazocine" title="Ketazocine">Ketazocine</a></li> <li><a href="/wiki/Laudanosine" title="Laudanosine">Laudanosine</a></li> <li><a href="/wiki/Leumorphin" title="Leumorphin">Leumorphin (dynorphin B-29)</a></li> <li><a href="/wiki/Levallorphan" title="Levallorphan">Levallorphan</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/Lofentanil" title="Lofentanil">Lofentanil</a></li> <li><a href="/wiki/LPK-26" title="LPK-26">LPK-26</a></li> <li><a href="/wiki/Lufuradom" title="Lufuradom">Lufuradom</a></li> <li><a href="/wiki/Matrine" title="Matrine">Matrine</a></li> <li><a href="/w/index.php?title=MB-1C-OH&action=edit&redlink=1" class="new" title="MB-1C-OH (page does not exist)">MB-1C-OH</a></li> <li><a href="/wiki/Menthol" title="Menthol">Menthol</a></li> <li><a href="/wiki/Metazocine" title="Metazocine">Metazocine</a></li> <li><a href="/wiki/Metkefamide" title="Metkefamide">Metkefamide</a></li> <li><a href="/wiki/Mianserin" title="Mianserin">Mianserin</a></li> <li><a href="/wiki/Mirtazapine" title="Mirtazapine">Mirtazapine</a></li> <li><a href="/wiki/Morphine" title="Morphine">Morphine</a></li> <li><a href="/wiki/Moxazocine" title="Moxazocine">Moxazocine</a></li> <li><a href="/w/index.php?title=MR-2034&action=edit&redlink=1" class="new" title="MR-2034 (page does not exist)">MR-2034</a></li> <li><a href="/w/index.php?title=N-MPPP&action=edit&redlink=1" class="new" title="N-MPPP (page does not exist)">N-MPPP</a></li> <li><a href="/wiki/Nalbuphine" title="Nalbuphine">Nalbuphine</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/wiki/Nalfurafine" title="Nalfurafine">Nalfurafine</a></li> <li><a href="/wiki/Nalmefene" title="Nalmefene">Nalmefene</a></li> <li><a href="/wiki/Nalodeine" title="Nalodeine">Nalodeine (N-allylnorcodeine)</a></li> <li><a href="/wiki/Nalorphine" title="Nalorphine">Nalorphine</a></li> <li><a href="/wiki/Naltriben" title="Naltriben">Naltriben</a></li> <li><a href="/wiki/Niravoline" title="Niravoline">Niravoline</a></li> <li><a href="/wiki/Norbuprenorphine" title="Norbuprenorphine">Norbuprenorphine</a></li> <li><a href="/wiki/Norbuprenorphine-3-glucuronide" title="Norbuprenorphine-3-glucuronide">Norbuprenorphine-3-glucuronide</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Norketamine" title="Norketamine">Norketamine</a></li> <li><a href="/wiki/Oripavine" title="Oripavine">Oripavine</a></li> <li><a href="/wiki/Oxilorphan" title="Oxilorphan">Oxilorphan</a></li> <li><a href="/wiki/Oxycodone" title="Oxycodone">Oxycodone</a></li> <li><a href="/wiki/Pentazocine" title="Pentazocine">Pentazocine</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Phenazocine" title="Phenazocine">Phenazocine</a></li> <li><a href="/wiki/Proxorphan" title="Proxorphan">Proxorphan</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/RB-64" title="RB-64">RB-64</a></li> <li><a href="/wiki/Salvinorin_A" title="Salvinorin A">Salvinorin A</a> (<a href="/wiki/Salvia_divinorum" title="Salvia divinorum">salvia</a>)</li> <li><a href="/wiki/Salvinorin_B_ethoxymethyl_ether" class="mw-redirect" title="Salvinorin B ethoxymethyl ether">Salvinorin B ethoxymethyl ether</a></li> <li><a href="/wiki/Salvinorin_B_methoxymethyl_ether" title="Salvinorin B methoxymethyl ether">Salvinorin B methoxymethyl ether</a></li> <li><a href="/wiki/Samidorphan" title="Samidorphan">Samidorphan</a></li> <li><a href="/wiki/Spiradoline" title="Spiradoline">Spiradoline</a> (U-62066)</li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li> <li><a href="/wiki/Tifluadom" title="Tifluadom">Tifluadom</a></li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a> (e.g., <a href="/wiki/Amitriptyline" title="Amitriptyline">amitriptyline</a>, <a href="/wiki/Desipramine" title="Desipramine">desipramine</a>, <a href="/wiki/Imipramine" title="Imipramine">imipramine</a>, <a href="/wiki/Nortriptyline" title="Nortriptyline">nortriptyline</a>)</li> <li><a href="/wiki/U-50488" title="U-50488">U-50488</a></li> <li><a href="/w/index.php?title=U-54494A&action=edit&redlink=1" class="new" title="U-54494A (page does not exist)">U-54494A</a></li> <li><a href="/wiki/U-69593" class="mw-redirect" title="U-69593">U-69593</a></li> <li><a href="/wiki/Xorphanol" title="Xorphanol">Xorphanol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/4%E2%80%B2-Hydroxyflavanone" class="mw-redirect" title="4′-Hydroxyflavanone">4′-Hydroxyflavanone</a></li> <li><a href="/wiki/4%27,7-Dihydroxyflavone" title="4',7-Dihydroxyflavone">4',7-Dihydroxyflavone</a></li> <li><a href="/wiki/5%27-Guanidinonaltrindole" title="5'-Guanidinonaltrindole">5'-GNTI</a></li> <li><a href="/wiki/6%27-Guanidinonaltrindole" title="6'-Guanidinonaltrindole">6'-GNTI</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol" title="6β-Naltrexol">6β-Naltrexol</a></li> <li><a href="/wiki/6%CE%B2-Naltrexol-d4" title="6β-Naltrexol-d4">6β-Naltrexol-d4</a></li> <li><a href="/wiki/Chlornaltrexamine" class="mw-redirect" title="Chlornaltrexamine">β-Chlornaltrexamine</a></li> <li><a href="/wiki/Buprenorphine/samidorphan" title="Buprenorphine/samidorphan">Buprenorphine/samidorphan</a></li> <li><a href="/wiki/Amentoflavone" title="Amentoflavone">Amentoflavone</a></li> <li><a href="/w/index.php?title=5%27-Acetamidinoethylnaltrindole&action=edit&redlink=1" class="new" title="5'-Acetamidinoethylnaltrindole (page does not exist)">ANTI</a></li> <li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a></li> <li><a href="/w/index.php?title=Arodyne&action=edit&redlink=1" class="new" title="Arodyne (page does not exist)">Arodyne</a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/wiki/Aticaprant" title="Aticaprant">Aticaprant</a></li> <li><a href="/wiki/Axelopran" title="Axelopran">Axelopran</a></li> <li><a href="/w/index.php?title=AZ-MTAB&action=edit&redlink=1" class="new" title="AZ-MTAB (page does not exist)">AZ-MTAB</a></li> <li><a href="/wiki/Binaltorphimine" title="Binaltorphimine">Binaltorphimine</a></li> <li><a href="/wiki/BU09059" title="BU09059">BU09059</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Catechin" title="Catechin">Catechin</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">Catechin gallate</a></li> <li><a href="/wiki/CERC-501" class="mw-redirect" title="CERC-501">CERC-501 (LY-2456302)</a></li> <li><a href="/wiki/Clocinnamox" title="Clocinnamox">Clocinnamox</a></li> <li><a href="/wiki/Icalcaprant" title="Icalcaprant">CVL-354</a></li> <li><a href="/w/index.php?title=Cyclofoxy&action=edit&redlink=1" class="new" title="Cyclofoxy (page does not exist)">Cyclofoxy</a></li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/w/index.php?title=DIPPA&action=edit&redlink=1" class="new" title="DIPPA (page does not exist)">DIPPA</a></li> <li><a href="/wiki/Gallocatechol" title="Gallocatechol">EGC</a></li> <li><a href="/wiki/Epicatechin_gallate" title="Epicatechin gallate">ECG</a></li> <li><a href="/wiki/Epicatechin" class="mw-redirect" title="Epicatechin">Epicatechin</a></li> <li><a href="/wiki/Hyperoside" title="Hyperoside">Hyperoside</a></li> <li><a href="/wiki/JDTic" title="JDTic">JDTic</a></li> <li><a href="/wiki/LY-255582" title="LY-255582">LY-255582</a></li> <li><a href="/wiki/LY-2196044" class="mw-redirect" title="LY-2196044">LY-2196044</a></li> <li><a href="/w/index.php?title=LY-2444296&action=edit&redlink=1" class="new" title="LY-2444296 (page does not exist)">LY-2444296</a></li> <li><a href="/wiki/LY-2459989" title="LY-2459989">LY-2459989</a></li> <li><a href="/w/index.php?title=LY-2795050&action=edit&redlink=1" class="new" title="LY-2795050 (page does not exist)">LY-2795050</a></li> <li><a href="/w/index.php?title=MeJDTic&action=edit&redlink=1" class="new" title="MeJDTic (page does not exist)">MeJDTic</a></li> <li><a href="/wiki/Methylnaltrexone" title="Methylnaltrexone">Methylnaltrexone</a></li> <li><a href="/w/index.php?title=ML190&action=edit&redlink=1" class="new" title="ML190 (page does not exist)">ML190</a></li> <li><a href="/w/index.php?title=ML350&action=edit&redlink=1" class="new" title="ML350 (page does not exist)">ML350</a></li> <li><a href="/w/index.php?title=MR-2266&action=edit&redlink=1" class="new" title="MR-2266 (page does not exist)">MR-2266</a></li> <li><a href="/w/index.php?title=N-Fluoropropyl-JDTic&action=edit&redlink=1" class="new" title="N-Fluoropropyl-JDTic (page does not exist)">N-Fluoropropyl-JDTic</a></li> <li><a class="mw-selflink selflink">Naloxone</a></li> <li><a href="/wiki/Naltrexone" title="Naltrexone">Naltrexone</a></li> <li><a href="/wiki/Naltrindole" title="Naltrindole">Naltrindole</a></li> <li><a href="/wiki/Naringenin" title="Naringenin">Naringenin</a></li> <li><a href="/wiki/Navacaprant" title="Navacaprant">Navacaprant</a></li> <li><a href="/wiki/Norbinaltorphimine" title="Norbinaltorphimine">Norbinaltorphimine</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Pawhuskin_A" title="Pawhuskin A">Pawhuskin A</a></li> <li><a href="/wiki/PF-4455242" class="mw-redirect" title="PF-4455242">PF-4455242</a></li> <li><a href="/wiki/RB-64" title="RB-64">RB-64</a></li> <li><a href="/wiki/Quadazocine" title="Quadazocine">Quadazocine</a></li> <li><a href="/wiki/Taxifolin" title="Taxifolin">Taxifolin</a></li> <li><a href="/w/index.php?title=UPHIT&action=edit&redlink=1" class="new" title="UPHIT (page does not exist)">UPHIT</a></li> <li><a href="/wiki/Zyklophin" title="Zyklophin">Zyklophin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Nociceptin_receptor" title="Nociceptin receptor">Nociceptin</a> (NOP)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=(Arg14,Lys15)Nociceptin&action=edit&redlink=1" class="new" title="(Arg14,Lys15)Nociceptin (page does not exist)">(Arg14,Lys15)Nociceptin</a></li> <li><a href="/w/index.php?title=((pF)Phe4)Nociceptin(1-13)NH2&action=edit&redlink=1" class="new" title="((pF)Phe4)Nociceptin(1-13)NH2 (page does not exist)">((pF)Phe4)Nociceptin(1-13)NH2</a></li> <li><a href="/w/index.php?title=(Phe1%CE%A8(CH2-NH)Gly2)Nociceptin(1-13)NH2&action=edit&redlink=1" class="new" title="(Phe1Ψ(CH2-NH)Gly2)Nociceptin(1-13)NH2 (page does not exist)">(Phe1Ψ(CH2-NH)Gly2)Nociceptin(1-13)NH2</a></li> <li><a href="/w/index.php?title=Ac-RYYRWK-NH2&action=edit&redlink=1" class="new" title="Ac-RYYRWK-NH2 (page does not exist)">Ac-RYYRWK-NH2</a></li> <li><a href="/w/index.php?title=Ac-RYYRIK-NH2&action=edit&redlink=1" class="new" title="Ac-RYYRIK-NH2 (page does not exist)">Ac-RYYRIK-NH2</a></li> <li><a href="/w/index.php?title=BU08070&action=edit&redlink=1" class="new" title="BU08070 (page does not exist)">BU08070</a></li> <li><a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Cebranopadol" title="Cebranopadol">Cebranopadol</a></li> <li><a href="/wiki/Dihydroetorphine" title="Dihydroetorphine">Dihydroetorphine</a></li> <li><a href="/wiki/Etorphine" title="Etorphine">Etorphine</a></li> <li><a href="/w/index.php?title=JNJ-19385899&action=edit&redlink=1" class="new" title="JNJ-19385899 (page does not exist)">JNJ-19385899</a></li> <li><a href="/wiki/Levomethorphan" title="Levomethorphan">Levomethorphan</a></li> <li><a href="/wiki/Levorphanol" title="Levorphanol">Levorphanol</a></li> <li><a href="/w/index.php?title=Lexanopadol&action=edit&redlink=1" class="new" title="Lexanopadol (page does not exist)">Lexanopadol</a></li> <li><a href="/wiki/MCOPPB" title="MCOPPB">MCOPPB</a></li> <li><a href="/wiki/MT-7716" title="MT-7716">MT-7716</a></li> <li><a href="/wiki/NNC_63-0532" title="NNC 63-0532">NNC 63-0532</a></li> <li><a href="/wiki/Nociceptin" title="Nociceptin">Nociceptin (orphanin FQ)</a></li> <li><a href="/w/index.php?title=Nociceptin_(1-11)&action=edit&redlink=1" class="new" title="Nociceptin (1-11) (page does not exist)">Nociceptin (1-11)</a></li> <li><a href="/w/index.php?title=Nociceptin_(1-13)NH2&action=edit&redlink=1" class="new" title="Nociceptin (1-13)NH2 (page does not exist)">Nociceptin (1-13)NH2</a></li> <li><a href="/wiki/Norbuprenorphine" title="Norbuprenorphine">Norbuprenorphine</a></li> <li><a href="/wiki/Methorphan" title="Methorphan">Racemethorphan</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan</a></li> <li><a href="/wiki/Ro64-6198" title="Ro64-6198">Ro64-6198</a></li> <li><a href="/wiki/Ro65-6570" title="Ro65-6570">Ro65-6570</a></li> <li><a href="/wiki/SCH-221510" title="SCH-221510">SCH-221510</a></li> <li><a href="/w/index.php?title=SCH-486757&action=edit&redlink=1" class="new" title="SCH-486757 (page does not exist)">SCH-486757</a></li> <li><a href="/w/index.php?title=SR-8993&action=edit&redlink=1" class="new" title="SR-8993 (page does not exist)">SR-8993</a></li> <li><a href="/wiki/SR-16435" title="SR-16435">SR-16435</a></li> <li><a href="/wiki/Sunobinop" title="Sunobinop">Sunobinop (S-117957)</a></li> <li><a href="/wiki/TH-030418" title="TH-030418">TH-030418</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=(Nphe1)Nociceptin(1-13)NH2&action=edit&redlink=1" class="new" title="(Nphe1)Nociceptin(1-13)NH2 (page does not exist)">(Nphe1)Nociceptin(1-13)NH2</a></li> <li><a href="/wiki/AT-076" title="AT-076">AT-076</a></li> <li><a href="/w/index.php?title=BAN-ORL-24&action=edit&redlink=1" class="new" title="BAN-ORL-24 (page does not exist)">BAN-ORL-24</a></li> <li><a href="/wiki/BTRX-246040" title="BTRX-246040">BTRX-246040 (LY-2940094)</a></li> <li><a href="/wiki/J-113397" class="mw-redirect" title="J-113397">J-113397</a></li> <li><a href="/wiki/JTC-801" title="JTC-801">JTC-801</a></li> <li><a href="/w/index.php?title=Naloxone_benzoylhydrazone&action=edit&redlink=1" class="new" title="Naloxone benzoylhydrazone (page does not exist)">NalBzOH</a></li> <li><a href="/w/index.php?title=Nociceptin_(1-7)&action=edit&redlink=1" class="new" title="Nociceptin (1-7) (page does not exist)">Nociceptin (1-7)</a></li> <li><a href="/w/index.php?title=Nocistatin&action=edit&redlink=1" class="new" title="Nocistatin (page does not exist)">Nocistatin</a></li> <li><a href="/wiki/SB-612111" class="mw-redirect" title="SB-612111">SB-612111</a></li> <li><a href="/w/index.php?title=SR-16430&action=edit&redlink=1" class="new" title="SR-16430 (page does not exist)">SR-16430</a></li> <li><a href="/wiki/Thienorphine" title="Thienorphine">Thienorphine</a></li> <li><a href="/w/index.php?title=Trap-101&action=edit&redlink=1" class="new" title="Trap-101 (page does not exist)">Trap-101</a></li> <li><a href="/w/index.php?title=UFP-101&action=edit&redlink=1" class="new" title="UFP-101 (page does not exist)">UFP-101</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enkephalinase_inhibitor" title="Enkephalinase inhibitor">Enkephalinase inhibitors</a>: <a href="/wiki/Amastatin" title="Amastatin">Amastatin</a></li> <li><a href="/w/index.php?title=BL-2401&action=edit&redlink=1" class="new" title="BL-2401 (page does not exist)">BL-2401</a></li> <li><a href="/wiki/Candoxatril" title="Candoxatril">Candoxatril</a></li> <li><a href="/wiki/Phenylalanine#D-,_L-_and_DL-phenylalanine" title="Phenylalanine">D-Phenylalanine</a></li> <li><a href="/w/index.php?title=Dexecadotril&action=edit&redlink=1" class="new" title="Dexecadotril (page does not exist)">Dexecadotril (retorphan)</a></li> <li><a href="/wiki/Ecadotril" title="Ecadotril">Ecadotril (sinorphan)</a></li> <li><a href="/wiki/Kelatorphan" title="Kelatorphan">Kelatorphan</a></li> <li><a href="/wiki/Racecadotril" title="Racecadotril">Racecadotril (acetorphan)</a></li> <li><a href="/wiki/RB-101" title="RB-101">RB-101</a></li> <li><a href="/wiki/RB-120" title="RB-120">RB-120</a></li> <li><a href="/wiki/RB-3007" title="RB-3007">RB-3007</a></li> <li><a href="/w/index.php?title=Opiorphan&action=edit&redlink=1" class="new" title="Opiorphan (page does not exist)">Opiorphan</a></li> <li><a href="/wiki/Selank" title="Selank">Selank</a></li> <li><a href="/wiki/Semax" title="Semax">Semax</a></li> <li><a href="/wiki/Spinorphin" title="Spinorphin">Spinorphin</a></li> <li><a href="/wiki/Thiorphan" title="Thiorphan">Thiorphan</a></li> <li><a href="/wiki/Tynorphin" title="Tynorphin">Tynorphin</a></li> <li><a href="/wiki/Ubenimex" title="Ubenimex">Ubenimex (bestatin)</a></li></ul> <ul><li>Propeptides: <a href="/wiki/Lipotropin" title="Lipotropin">β-Lipotropin (proendorphin)</a></li> <li><a href="/wiki/Prodynorphin" title="Prodynorphin">Prodynorphin</a></li> <li><a href="/wiki/Proenkephalin" title="Proenkephalin">Proenkephalin</a></li> <li><a href="/w/index.php?title=Pronociceptin&action=edit&redlink=1" class="new" title="Pronociceptin (page does not exist)">Pronociceptin</a></li> <li><a href="/wiki/Proopiomelanocortin" title="Proopiomelanocortin">Proopiomelanocortin (POMC)</a></li></ul> <ul><li>Others: <a href="/wiki/Kyotorphin" title="Kyotorphin">Kyotorphin</a> (met-enkephalin releaser/degradation stabilizer)</li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Sigma_receptor_modulators212" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Sigma_receptor_modulators" title="Template:Sigma receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Sigma_receptor_modulators" title="Template talk:Sigma receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Sigma_receptor_modulators" title="Special:EditPage/Template:Sigma receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Sigma_receptor_modulators212" style="font-size:114%;margin:0 4em"><a href="/wiki/Sigma_receptor" title="Sigma receptor">Sigma receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Sigma-1_receptor" title="Sigma-1 receptor">σ1</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/3-PPP" title="3-PPP">3-PPP</a></li> <li><a href="/wiki/4-PPBP" title="4-PPBP">4-PPBP</a></li> <li><a href="/wiki/5-MeO-DMT" title="5-MeO-DMT">5-MeO-DMT</a></li> <li><a href="/wiki/Alazocine" title="Alazocine">Alazocine (SKF-10047)</a></li> <li><a href="/wiki/Amantadine" title="Amantadine">Amantadine</a></li> <li><a href="/wiki/Arketamine" title="Arketamine">Arketamine</a></li> <li><a href="/w/index.php?title=BD-737&action=edit&redlink=1" class="new" title="BD-737 (page does not exist)">BD-737</a></li> <li><a href="/wiki/BD-1052" class="mw-redirect" title="BD-1052">BD-1052</a></li> <li><a href="/wiki/Blarcamesine" title="Blarcamesine">Blarcamesine</a></li> <li><a href="/wiki/Captodiame" title="Captodiame">Captodiame</a></li> <li><a href="/wiki/Citalopram" title="Citalopram">Citalopram</a></li> <li><a href="/wiki/Calcitonin_gene-related_peptide" title="Calcitonin gene-related peptide"><abbr title="Calcitonin gene-related peptide">CGRP</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Calcitonin gene-related peptide</li> <li><a href="/wiki/Cloperastine" title="Cloperastine">Cloperastine</a></li> <li><a href="/wiki/Cocaine" title="Cocaine">Cocaine</a></li> <li><a href="/wiki/Cutamesine" title="Cutamesine">Cutamesine (SA-4503)</a></li> <li><a href="/wiki/Cyclazocine" title="Cyclazocine">Cyclazocine</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">Dehydroepiandrosterone (DHEA)</a> (<a href="/wiki/Prasterone" title="Prasterone">prasterone</a>)</li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">Dehydroepiandrosterone sulfate (DHEA-S)</a> (<a href="/wiki/Prasterone_sulfate" title="Prasterone sulfate">prasterone sulfate</a>)</li> <li><a href="/wiki/Dextrallorphan" title="Dextrallorphan">Dextrallorphan</a></li> <li><a href="/wiki/Dextromethorphan" title="Dextromethorphan">Dextromethorphan (DXM)</a></li> <li><a href="/wiki/Dextrorphan" title="Dextrorphan">Dextrorphan (DXO)</a></li> <li><a href="/wiki/Dimemorfan" title="Dimemorfan">Dimemorfan</a></li> <li><a href="/wiki/Dimethyltryptamine" class="mw-redirect" title="Dimethyltryptamine">Dimethyltryptamine (DMT)</a></li> <li><a href="/wiki/Ditolylguanidine" title="Ditolylguanidine">Ditolylguanidine (DTG)</a></li> <li><a href="/wiki/Donepezil" title="Donepezil">Donepezil</a></li> <li><a href="/wiki/Eliprodil" title="Eliprodil">Eliprodil</a></li> <li><a href="/wiki/Escitalopram" title="Escitalopram">Escitalopram</a></li> <li><a href="/wiki/Fabomotizole" title="Fabomotizole">Fabomotizole (afobazole)</a></li> <li><a href="/wiki/Fluoxetine" title="Fluoxetine">Fluoxetine</a></li> <li><a href="/wiki/Fluvoxamine" title="Fluvoxamine">Fluvoxamine</a></li> <li><a href="/wiki/Ifenprodil" title="Ifenprodil">Ifenprodil</a></li> <li><a href="/wiki/Igmesine" title="Igmesine">Igmesine (JO-1784)</a></li> <li><a href="/w/index.php?title=IPAB_(drug)&action=edit&redlink=1" class="new" title="IPAB (drug) (page does not exist)">IPAB</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/L-687384" class="mw-redirect" title="L-687384">L-687384</a></li> <li><a href="/wiki/MDMA" title="MDMA"><abbr title="Methylenedioxymethamphetamine">MDMA</abbr> (midomafetamine)</a></li> <li><a href="/wiki/Memantine" title="Memantine">Memantine</a></li> <li><a href="/wiki/Methamphetamine" title="Methamphetamine">Methamphetamine</a></li> <li><a href="/wiki/Methoxetamine" title="Methoxetamine">Methoxetamine</a></li> <li><a href="/wiki/Methylphenidate" title="Methylphenidate">Methylphenidate</a></li> <li><a href="/wiki/Nepinalone" title="Nepinalone">Nepinalone</a></li> <li><a href="/wiki/Neuropeptide_Y" title="Neuropeptide Y">Neuropeptide Y</a></li> <li><a href="/wiki/Noscapine" title="Noscapine">Noscapine</a></li> <li><a href="/w/index.php?title=OPC-14523&action=edit&redlink=1" class="new" title="OPC-14523 (page does not exist)">OPC-14523</a></li> <li><a href="/wiki/Opipramol" title="Opipramol">Opipramol</a></li> <li><a href="/wiki/Pentazocine" title="Pentazocine">Pentazocine</a></li> <li><a href="/wiki/Pentoxyverine" title="Pentoxyverine">Pentoxyverine (carbetapentane)</a></li> <li><a href="/wiki/PRE-084" title="PRE-084">PRE-084</a></li> <li><a href="/wiki/Pregnenolone" title="Pregnenolone">Pregnenolone</a></li> <li><a href="/wiki/Pregnenolone_sulfate" title="Pregnenolone sulfate">Pregnenolone sulfate</a></li> <li><a href="/wiki/Pridopidine" title="Pridopidine">Pridopidine</a></li> <li><a href="/wiki/Racemethorphan" class="mw-redirect" title="Racemethorphan">Racemethorphan (methorphan)</a></li> <li><a href="/wiki/Racemorphan" title="Racemorphan">Racemorphan (morphanol)</a></li> <li><a href="/w/index.php?title=UMB-23&action=edit&redlink=1" class="new" title="UMB-23 (page does not exist)">UMB-23</a></li> <li><a href="/w/index.php?title=UMB-82&action=edit&redlink=1" class="new" title="UMB-82 (page does not exist)">UMB-82</a></li></ul> <ul><li>Antagonists: <a href="/wiki/3-PPP" title="3-PPP">3-PPP</a></li> <li><a href="/wiki/AC-927" class="mw-redirect" title="AC-927">AC-927</a></li> <li><a href="/wiki/BD-1008" class="mw-redirect" title="BD-1008">BD-1008</a></li> <li><a href="/wiki/BD-1031" class="mw-redirect" title="BD-1031">BD-1031</a></li> <li><a href="/wiki/BD-1047" title="BD-1047">BD-1047</a></li> <li><a href="/wiki/BD-1060" class="mw-redirect" title="BD-1060">BD-1060</a></li> <li><a href="/wiki/BD-1063" class="mw-redirect" title="BD-1063">BD-1063</a></li> <li><a href="/wiki/BD-1067" class="mw-redirect" title="BD-1067">BD-1067</a></li> <li><a href="/wiki/BMY-14802" title="BMY-14802">BMY-14802 (BMS-181100)</a></li> <li><a href="/wiki/CM-156" class="mw-redirect" title="CM-156">CM-156</a></li> <li><a href="/w/index.php?title=Dup-734&action=edit&redlink=1" class="new" title="Dup-734 (page does not exist)">Dup-734</a></li> <li><a href="/w/index.php?title=E-5842&action=edit&redlink=1" class="new" title="E-5842 (page does not exist)">E-5842</a></li> <li><a href="/wiki/E-52862" title="E-52862">E-52862 (S1RA)</a></li> <li><a href="/wiki/Haloperidol" title="Haloperidol">Haloperidol</a></li> <li><a href="/w/index.php?title=LR-132&action=edit&redlink=1" class="new" title="LR-132 (page does not exist)">LR-132</a></li> <li><a href="/w/index.php?title=LR-172&action=edit&redlink=1" class="new" title="LR-172 (page does not exist)">LR-172</a></li> <li><a href="/wiki/MS-377" title="MS-377">MS-377</a></li> <li><a href="/wiki/NE-100" title="NE-100">NE-100</a></li> <li><a href="/w/index.php?title=NPC-16377&action=edit&redlink=1" class="new" title="NPC-16377 (page does not exist)">NPC-16377</a></li> <li><a href="/wiki/Panamesine" title="Panamesine">Panamesine (EMD-57455)</a></li> <li><a href="/w/index.php?title=PD-144418&action=edit&redlink=1" class="new" title="PD-144418 (page does not exist)">PD-144418</a></li> <li><a href="/wiki/Pentazocine" title="Pentazocine">Pentazocine</a></li> <li><a href="/wiki/Progesterone" title="Progesterone">Progesterone</a></li> <li><a href="/wiki/Rimcazole" title="Rimcazole">Rimcazole (BW-234U)</a></li> <li><a href="/wiki/Sertraline" title="Sertraline">Sertraline</a></li> <li><a href="/w/index.php?title=SR-31742A&action=edit&redlink=1" class="new" title="SR-31742A (page does not exist)">SR-31742A</a></li></ul> <ul><li>Allosteric modulators: <a href="/wiki/Phenytoin" title="Phenytoin">Phenytoin</a>; Positive: <a href="/wiki/Methylphenylpiracetam" title="Methylphenylpiracetam">Methylphenylpiracetam</a></li> <li><a href="/w/index.php?title=SOMCL-668&action=edit&redlink=1" class="new" title="SOMCL-668 (page does not exist)">SOMCL-668</a></li></ul> <ul><li>Unknown/unsorted: <a href="/w/index.php?title=3-Methoxydextrallorphan&action=edit&redlink=1" class="new" title="3-Methoxydextrallorphan (page does not exist)">3-Methoxydextrallorphan</a></li> <li><a href="/wiki/3-MeO-PCP" title="3-MeO-PCP">3-MeO-PCP</a></li> <li><a href="/wiki/4C-T-2" title="4C-T-2">4C-T-2</a></li> <li><a href="/w/index.php?title=4-IBP&action=edit&redlink=1" class="new" title="4-IBP (page does not exist)">4-IBP</a></li> <li><a href="/w/index.php?title=4-IPBS&action=edit&redlink=1" class="new" title="4-IPBS (page does not exist)">4-IPBS</a></li> <li><a href="/wiki/4-MeO-PCP" title="4-MeO-PCP">4-MeO-PCP</a></li> <li><a href="/wiki/5-MeO-DALT" title="5-MeO-DALT">5-MeO-DALT</a></li> <li><a href="/wiki/5-MeO-DiPT" title="5-MeO-DiPT">5-MeO-DiPT</a></li> <li><a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/w/index.php?title=Azidopamil&action=edit&redlink=1" class="new" title="Azidopamil (page does not exist)">Azidopamil</a></li> <li><a href="/wiki/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a></li> <li><a href="/wiki/Clemastine" title="Clemastine">Clemastine</a></li> <li><a href="/wiki/Clomipramine" title="Clomipramine">Clomipramine</a></li> <li><a href="/wiki/Clorgiline" title="Clorgiline">Clorgiline</a></li> <li><a href="/wiki/D-Deprenyl" title="D-Deprenyl">D-Deprenyl</a></li> <li><a href="/wiki/N,N-Diisopropyltryptamine" class="mw-redirect" title="N,N-Diisopropyltryptamine"><abbr title="N,N-Diisopropyltryptamine">DiPT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip N,N-Diisopropyltryptamine</li> <li><a href="/wiki/N,N-Dipropyltryptamine" class="mw-redirect" title="N,N-Dipropyltryptamine"><abbr title="N,N-Dipropyltryptamine">DPT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip N,N-Dipropyltryptamine</li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/Imipramine" title="Imipramine">Imipramine</a></li> <li><a href="/w/index.php?title=KCR-12-83.1&action=edit&redlink=1" class="new" title="KCR-12-83.1 (page does not exist)">KCR-12-83.1</a></li> <li><a href="/wiki/Nemonapride" title="Nemonapride">Nemonapride</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/w/index.php?title=RHL-033&action=edit&redlink=1" class="new" title="RHL-033 (page does not exist)">RHL-033</a></li> <li><a href="/wiki/RS-67,333" title="RS-67,333">RS-67,333</a></li> <li><a href="/wiki/RTI-55" title="RTI-55">RTI-55</a></li> <li><a href="/wiki/Saffron" title="Saffron">Saffron</a></li> <li><a href="/wiki/Safinamide" title="Safinamide">Safinamide</a></li> <li><a href="/wiki/Selegiline" title="Selegiline">Selegiline</a></li> <li><a href="/w/index.php?title=Spipethiane&action=edit&redlink=1" class="new" title="Spipethiane (page does not exist)">Spipethiane</a></li> <li><a href="/wiki/Trifluoperazine" title="Trifluoperazine">Trifluoperazine</a></li> <li><a href="/wiki/W-18_(drug)" title="W-18 (drug)">W-18</a></li> <li><a href="/wiki/YKP10A" class="mw-redirect" title="YKP10A">YKP10A</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Sigma-2_receptor" title="Sigma-2 receptor">σ2</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/3-PPP" title="3-PPP">3-PPP</a></li> <li><a href="/wiki/Arketamine" title="Arketamine">Arketamine</a></li> <li><a href="/wiki/BD-1047" title="BD-1047">BD-1047</a></li> <li><a href="/wiki/BD1063" title="BD1063">BD1063</a></li> <li><a href="/wiki/Ditolylguanidine" title="Ditolylguanidine">Ditolylguanidine (DTG)</a></li> <li><a href="/w/index.php?title=DKR-1005&action=edit&redlink=1" class="new" title="DKR-1005 (page does not exist)">DKR-1005</a></li> <li><a href="/w/index.php?title=DKR-1051&action=edit&redlink=1" class="new" title="DKR-1051 (page does not exist)">DKR-1051</a></li> <li><a href="/wiki/Haloperidol" title="Haloperidol">Haloperidol</a></li> <li><a href="/wiki/Ifenprodil" title="Ifenprodil">Ifenprodil</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/MDMA" title="MDMA"><abbr title="Methylenedioxymethamphetamine">MDMA</abbr> (midomafetamine)</a></li> <li><a href="/wiki/Methamphetamine" title="Methamphetamine">Methamphetamine</a></li> <li><a href="/w/index.php?title=OPC-14523&action=edit&redlink=1" class="new" title="OPC-14523 (page does not exist)">OPC-14523</a></li> <li><a href="/wiki/Opipramol" title="Opipramol">Opipramol</a></li> <li><a href="/wiki/PB-28" title="PB-28">PB-28</a></li> <li><a href="/wiki/Phencyclidine" title="Phencyclidine">Phencyclidine</a></li> <li><a href="/wiki/Siramesine" title="Siramesine">Siramesine (Lu 28-179)</a></li> <li><a href="/w/index.php?title=UKH-1114&action=edit&redlink=1" class="new" title="UKH-1114 (page does not exist)">UKH-1114</a></li></ul> <ul><li>Antagonists: <a href="/wiki/AC-927" class="mw-redirect" title="AC-927">AC-927</a></li> <li><a href="/wiki/BD-1008" class="mw-redirect" title="BD-1008">BD-1008</a></li> <li><a href="/wiki/BD-1067" class="mw-redirect" title="BD-1067">BD-1067</a></li> <li><a href="/wiki/CM-156" class="mw-redirect" title="CM-156">CM-156</a></li> <li><a href="/w/index.php?title=CT-1812&action=edit&redlink=1" class="new" title="CT-1812 (page does not exist)">CT-1812</a></li> <li><a href="/w/index.php?title=LR-172&action=edit&redlink=1" class="new" title="LR-172 (page does not exist)">LR-172</a></li> <li><a href="/wiki/MIN-101" class="mw-redirect" title="MIN-101">MIN-101</a></li> <li><a href="/wiki/Panamesine" title="Panamesine">Panamesine (EMD-57455)</a></li> <li><a href="/w/index.php?title=SAS-0132&action=edit&redlink=1" class="new" title="SAS-0132 (page does not exist)">SAS-0132</a></li></ul> <ul><li>Unknown/unsorted: <a href="/w/index.php?title=3-Methoxydextrallorphan&action=edit&redlink=1" class="new" title="3-Methoxydextrallorphan (page does not exist)">3-Methoxydextrallorphan</a></li> <li><a href="/wiki/3-MeO-PCE" title="3-MeO-PCE">3-MeO-PCE</a></li> <li><a href="/wiki/4-MeO-PCP" title="4-MeO-PCP">4-MeO-PCP</a></li> <li><a href="/wiki/5-MeO-DALT" title="5-MeO-DALT">5-MeO-DALT</a></li> <li><a href="/wiki/5-MeO-DiPT" title="5-MeO-DiPT">5-MeO-DiPT</a></li> <li><a href="/wiki/Clemastine" title="Clemastine">Clemastine</a></li> <li><a href="/wiki/N,N-Diisopropyltryptamine" class="mw-redirect" title="N,N-Diisopropyltryptamine"><abbr title="N,N-Diisopropyltryptamine">DiPT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip N,N-Diisopropyltryptamine</li> <li><a href="/wiki/N,N-Dipropyltryptamine" class="mw-redirect" title="N,N-Dipropyltryptamine"><abbr title="N,N-Dipropyltryptamine">DPT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip N,N-Dipropyltryptamine</li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/Lu_29-252" title="Lu 29-252">Lu 29-252</a></li> <li><a href="/wiki/Nemonapride" title="Nemonapride">Nemonapride</a></li> <li><a href="/wiki/Nepinalone" title="Nepinalone">Nepinalone</a></li> <li><a href="/wiki/Noribogaine" title="Noribogaine">Noribogaine</a></li> <li><a href="/wiki/Pentazocine" title="Pentazocine">Pentazocine</a></li> <li><a href="/wiki/RS-67,333" title="RS-67,333">RS-67,333</a></li> <li><a href="/wiki/Safinamide" title="Safinamide">Safinamide</a></li> <li><a href="/wiki/3,4,5-Trimethoxyamphetamine" title="3,4,5-Trimethoxyamphetamine"><abbr title="3,4,5-Trimethoxyamphetamine">TMA</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip 3,4,5-Trimethoxyamphetamine</li> <li><a href="/w/index.php?title=UMB-23&action=edit&redlink=1" class="new" title="UMB-23 (page does not exist)">UMB-23</a></li> <li><a href="/w/index.php?title=UMB-82&action=edit&redlink=1" class="new" title="UMB-82 (page does not exist)">UMB-82</a></li> <li><a href="/wiki/W-18_(drug)" title="W-18 (drug)">W-18</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Agonists: <a href="/wiki/Berberine" title="Berberine">Berberine</a></li> <li><a href="/wiki/Ethylketazocine" title="Ethylketazocine">Ethylketazocine</a></li> <li><a href="/wiki/Fourphit" title="Fourphit">Fourphit</a></li> <li><a href="/wiki/Metaphit" title="Metaphit">Metaphit</a></li> <li><a href="/wiki/Naluzotan" title="Naluzotan">Naluzotan</a></li> <li><a href="/wiki/Tapentadol" title="Tapentadol">Tapentadol</a></li> <li><a href="/wiki/Tenocyclidine" title="Tenocyclidine">Tenocyclidine</a></li></ul> <ul><li>Antagonists: <a href="/w/index.php?title=AHD1&action=edit&redlink=1" class="new" title="AHD1 (page does not exist)">AHD1</a></li> <li><a href="/w/index.php?title=AZ66&action=edit&redlink=1" class="new" title="AZ66 (page does not exist)">AZ66</a></li> <li><a href="/wiki/Lamotrigine" title="Lamotrigine">Lamotrigine</a></li> <li><a class="mw-selflink selflink">Naloxone</a></li> <li><a href="/w/index.php?title=SM-21&action=edit&redlink=1" class="new" title="SM-21 (page does not exist)">SM-21</a></li> <li><a href="/w/index.php?title=UMB-100&action=edit&redlink=1" class="new" title="UMB-100 (page does not exist)">UMB-100</a></li> <li><a href="/w/index.php?title=UMB-101&action=edit&redlink=1" class="new" title="UMB-101 (page does not exist)">UMB-101</a></li> <li><a href="/w/index.php?title=UMB-103&action=edit&redlink=1" class="new" title="UMB-103 (page does not exist)">UMB-103</a></li> <li><a href="/w/index.php?title=UMB-116&action=edit&redlink=1" class="new" title="UMB-116 (page does not exist)">UMB-116</a></li> <li><a href="/w/index.php?title=YZ-011&action=edit&redlink=1" class="new" title="YZ-011 (page does not exist)">YZ-011</a></li> <li><a href="/w/index.php?title=YZ-069&action=edit&redlink=1" class="new" title="YZ-069 (page does not exist)">YZ-069</a></li> <li><a href="/w/index.php?title=YZ-185&action=edit&redlink=1" class="new" title="YZ-185 (page does not exist)">YZ-185</a></li></ul> <ul><li>Allosteric modulators: <a href="/wiki/SKF-83959" class="mw-redirect" title="SKF-83959">SKF-83959</a></li></ul> <ul><li>Unknown/unsorted: <a href="/wiki/18-Methoxycoronaridine" title="18-Methoxycoronaridine">18-Methoxycoronaridine</a></li> <li><a href="/w/index.php?title=BMY-13980&action=edit&redlink=1" class="new" title="BMY-13980 (page does not exist)">BMY-13980</a></li> <li><a href="/wiki/Butaclamol" title="Butaclamol">Butaclamol</a></li> <li><a href="/wiki/Caramiphen" title="Caramiphen">Caramiphen</a></li> <li><a href="/w/index.php?title=Carvotroline&action=edit&redlink=1" class="new" title="Carvotroline (page does not exist)">Carvotroline</a></li> <li><a href="/wiki/Chlorphenamine" title="Chlorphenamine">Chlorphenamine (chlorpheniramine)</a></li> <li><a href="/wiki/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a></li> <li><a href="/wiki/Cinnarizine" title="Cinnarizine">Cinnarizine</a></li> <li><a href="/w/index.php?title=Cinuperone&action=edit&redlink=1" class="new" title="Cinuperone (page does not exist)">Cinuperone</a></li> <li><a href="/wiki/Clocapramine" title="Clocapramine">Clocapramine</a></li> <li><a href="/wiki/Dezocine" title="Dezocine">Dezocine</a></li> <li><a href="/w/index.php?title=EMD-59983&action=edit&redlink=1" class="new" title="EMD-59983 (page does not exist)">EMD-59983</a></li> <li><a href="/wiki/Hypericin" title="Hypericin">Hypericin</a> (<a href="/wiki/St._John%27s_wort" class="mw-redirect" title="St. John's wort">St. John's wort</a>)</li> <li><a href="/wiki/Fluphenazine" title="Fluphenazine">Fluphenazine</a></li> <li><a href="/wiki/Gevotroline" title="Gevotroline">Gevotroline (WY-47384)</a></li> <li><a href="/wiki/Mepyramine" title="Mepyramine">Mepyramine (pyrilamine)</a></li> <li><a href="/wiki/Molindone" title="Molindone">Molindone</a></li> <li><a href="/wiki/Perphenazine" title="Perphenazine">Perphenazine</a></li> <li><a href="/wiki/Pimozide" title="Pimozide">Pimozide</a></li> <li><a href="/wiki/Proadifen" title="Proadifen">Proadifen</a></li> <li><a href="/wiki/Promethazine" title="Promethazine">Promethazine</a></li> <li><a href="/wiki/Propranolol" title="Propranolol">Propranolol</a></li> <li><a href="/wiki/Quinidine" title="Quinidine">Quinidine</a></li> <li><a href="/wiki/Remoxipride" title="Remoxipride">Remoxipride</a></li> <li><a href="/w/index.php?title=SL_82.0715&action=edit&redlink=1" class="new" title="SL 82.0715 (page does not exist)">SL 82.0715</a></li> <li><a href="/w/index.php?title=SR-31747A&action=edit&redlink=1" class="new" title="SR-31747A (page does not exist)">SR-31747A</a></li> <li><a href="/wiki/Tiospirone" title="Tiospirone">Tiospirone (BMY-13859)</a></li> <li><a href="/wiki/Venlafaxine" title="Venlafaxine">Venlafaxine</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div>See also: <a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Emergency_medicine519" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Emergency_medicine" title="Template:Emergency medicine"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Emergency_medicine" title="Template talk:Emergency medicine"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Emergency_medicine" title="Special:EditPage/Template:Emergency medicine"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Emergency_medicine519" style="font-size:114%;margin:0 4em"><a href="/wiki/Emergency_medicine" title="Emergency medicine">Emergency medicine</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Emergency medicine</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Emergency_department" title="Emergency department">Emergency department</a></li> <li><a href="/wiki/Emergency_medical_services" title="Emergency medical services">Emergency medical services</a></li> <li><a href="/wiki/Emergency_nursing" title="Emergency nursing">Emergency nursing</a></li> <li><a href="/wiki/Emergency_psychiatry" title="Emergency psychiatry">Emergency psychiatry</a></li> <li><a href="/wiki/Golden_hour_(medicine)" title="Golden hour (medicine)">Golden hour</a></li> <li><a href="/wiki/Medical_emergency" title="Medical emergency">Medical emergency</a></li> <li><a href="/wiki/International_emergency_medicine" title="International emergency medicine">International emergency medicine</a></li> <li><a href="/wiki/Pediatric_emergency_medicine" title="Pediatric emergency medicine">Pediatric emergency medicine</a></li> <li><a href="/wiki/Pre-hospital_emergency_medicine" title="Pre-hospital emergency medicine">Pre-hospital emergency medicine</a></li> <li><a href="/wiki/Major_trauma" title="Major trauma">Major trauma</a></li> <li><a href="/wiki/Trauma_center" title="Trauma center">Trauma center</a></li> <li><a href="/wiki/Triage" title="Triage">Triage</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Category:Emergency_medical_equipment" title="Category:Emergency medical equipment">Equipment</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bag_valve_mask" title="Bag valve mask">Bag valve mask</a> (BVM)</li> <li><a href="/wiki/Chest_tube" title="Chest tube">Chest tube</a></li> <li><a href="/wiki/Defibrillation" title="Defibrillation">Defibrillation</a> (<a href="/wiki/Automated_external_defibrillator" title="Automated external defibrillator">AED</a></li> <li><a href="/wiki/Implantable_cardioverter-defibrillator" title="Implantable cardioverter-defibrillator">ICD</a>)</li> <li><a href="/wiki/Electrocardiography" title="Electrocardiography">Electrocardiogram</a> (ECG/EKG)</li> <li><a href="/wiki/Intraosseous_infusion" title="Intraosseous infusion">Intraosseous infusion</a> (IO)</li> <li><a href="/wiki/Intravenous_therapy" title="Intravenous therapy">Intravenous therapy</a> (IV)</li> <li><a href="/wiki/Tracheal_intubation" title="Tracheal intubation">Tracheal intubation</a></li> <li><a href="/wiki/Laryngeal_tube" title="Laryngeal tube">Laryngeal tube</a></li> <li><a href="/wiki/Combitube" title="Combitube">Combitube</a></li> <li><a href="/wiki/Nasopharyngeal_airway" title="Nasopharyngeal airway">Nasopharyngeal airway</a> (NPA)</li> <li><a href="/wiki/Oropharyngeal_airway" title="Oropharyngeal airway">Oropharyngeal airway</a> (OPA)</li> <li><a href="/wiki/Pocket_mask" title="Pocket mask">Pocket mask</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Drugs</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenosine" title="Adenosine">Adenosine</a></li> <li><a href="/wiki/Amiodarone" title="Amiodarone">Amiodarone</a></li> <li><a href="/wiki/Atropine" title="Atropine">Atropine</a></li> <li><a href="/wiki/Dopamine" title="Dopamine">Dopamine</a></li> <li><a href="/wiki/Epinephrine" class="mw-redirect" title="Epinephrine">Epinephrine / Adrenaline</a></li> <li><a class="mw-selflink selflink">Naloxone</a></li> <li><a href="/wiki/Magnesium_sulfate" title="Magnesium sulfate">Magnesium sulfate</a></li> <li><a href="/wiki/Sodium_bicarbonate" title="Sodium bicarbonate">Sodium bicarbonate</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Category:Emergency_medicine_organisations" title="Category:Emergency medicine organisations">Organisations</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/International_Federation_for_Emergency_Medicine" title="International Federation for Emergency Medicine">International Federation for Emergency Medicine</a> (<a href="/wiki/International_Conference_on_Emergency_Medicine" title="International Conference on Emergency Medicine">International Conference on Emergency Medicine</a>)</li> <li><a href="/wiki/American_College_of_Emergency_Physicians" title="American College of Emergency Physicians">American College of Emergency Physicians</a></li> <li><a href="/wiki/Australasian_College_for_Emergency_Medicine" title="Australasian College for Emergency Medicine">Australasian College for Emergency Medicine</a></li> <li><a href="/wiki/Canadian_Association_of_Emergency_Physicians" title="Canadian Association of Emergency Physicians">Canadian Association of Emergency Physicians</a></li> <li><a href="/wiki/Royal_College_of_Emergency_Medicine" title="Royal College of Emergency Medicine">Royal College of Emergency Medicine</a></li> <li><a href="/wiki/European_Society_for_Emergency_Medicine" title="European Society for Emergency Medicine">European Society for Emergency Medicine</a></li> <li><a href="/wiki/Asian_Society_for_Emergency_Medicine" class="mw-redirect" title="Asian Society for Emergency Medicine">Asian Society for Emergency Medicine</a></li> <li><a href="/wiki/American_Academy_of_Emergency_Medicine" title="American Academy of Emergency Medicine">American Academy of Emergency Medicine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Category:Emergency_medicine_courses" title="Category:Emergency medicine courses">Courses</a> / <a href="/wiki/Category:Emergency_life_support" title="Category:Emergency life support">Life support</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/First_aid" title="First aid">First aid</a></li> <li><a href="/wiki/Cardiopulmonary_resuscitation" title="Cardiopulmonary resuscitation">Cardiopulmonary resuscitation</a> (CPR)</li> <li><a href="/wiki/Mouth-to-mouth_resuscitation" title="Mouth-to-mouth resuscitation">Mouth-to-mouth resuscitation</a></li> <li><a href="/wiki/Basic_life_support" title="Basic life support">Basic life support</a> (BLS)</li> <li><a href="/wiki/Advanced_cardiac_life_support" title="Advanced cardiac life support">Advanced cardiac life support</a> (ACLS)</li> <li><a href="/wiki/Advanced_trauma_life_support" title="Advanced trauma life support">Advanced trauma life support</a> (ATLS)</li> <li><a href="/wiki/Neonatal_Resuscitation_Program" title="Neonatal Resuscitation Program">Neonatal Resuscitation Program</a> (NRP)</li> <li><a href="/wiki/Acute_Care_of_at-Risk_Newborns" title="Acute Care of at-Risk Newborns">Acute Care of at-Risk Newborns</a> (ACoRN)</li> <li><a href="/wiki/Pediatric_basic_life_support" title="Pediatric basic life support">Pediatric basic life support</a> (PBLS)</li> <li><a href="/wiki/Pediatric_Advanced_Life_Support" class="mw-redirect" title="Pediatric Advanced Life Support">Pediatric Advanced Life Support</a> (PALS)</li> <li><a href="/wiki/Advanced_Life_Support_in_Obstetrics" title="Advanced Life Support in Obstetrics">Advanced Life Support in Obstetrics</a> (ALSO)</li> <li><a href="/wiki/Care_of_the_Critically_Ill_Surgical_Patient" title="Care of the Critically Ill Surgical Patient">Care of the Critically Ill Surgical Patient</a> (CCrISP)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Scoring systems</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/NACA_score" title="NACA score">NACA score</a></li> <li><a href="/wiki/Injury_Severity_Score" title="Injury Severity Score">Injury Severity Score</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <ul><li><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/9/96/Symbol_category_class.svg/16px-Symbol_category_class.svg.png" decoding="async" width="16" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/9/96/Symbol_category_class.svg/23px-Symbol_category_class.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/9/96/Symbol_category_class.svg/31px-Symbol_category_class.svg.png 2x" data-file-width="180" data-file-height="185" /> <a href="/wiki/Category:Emergency_medicine" title="Category:Emergency medicine">Category</a></li> <li><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/41/Global_thinking.svg/10px-Global_thinking.svg.png" decoding="async" width="10" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/41/Global_thinking.svg/15px-Global_thinking.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/41/Global_thinking.svg/21px-Global_thinking.svg.png 2x" data-file-width="130" data-file-height="200" /> <a href="/wiki/Outline_of_emergency_medicine" title="Outline of emergency medicine">Outline</a></li></ul> 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