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Like any other process, it is also subjected to lots of deregulations and can lead to diseases" /> <meta property="article:author" content="https://sbvu.academia.edu/vimalaananthy" /> <meta name="description" content="Apoptosis (programmed cell death) is a natural process that helps in removing potentially harmful cells from the body and replacing it with normal ones. Like any other process, it is also subjected to lots of deregulations and can lead to diseases" /> <title>(PDF) Drugs modulating apoptosis: current status | vimala ananthy - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/122826662/Drugs_modulating_apoptosis_current_status" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732397046000); window.Aedu.timeDifference = new Date().getTime() - 1732397046000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"Apoptosis (programmed cell death) is a natural process that helps in removing potentially harmful cells from the body and replacing it with normal ones. Like any other process, it is also subjected to lots of deregulations and can lead to diseases like cancer, neurodegenerative conditions, multiple sclerosis, Parkinson鈥檚 disease, autoimmune disorders and inappropriate death of cells after liver failure, stroke and myocardial infarction. The knowledge of the molecular mechanisms involved in apoptosis has been progressed tremendously. Thus, therapeutics targeting apoptosis have been emerged as a novel approach for treating various disease conditions. Current approaches induce or inhibit apoptosis by targeting the key regulators of apoptosis such as Bcl2 family of proteins, TRAIL, caspases, MDM2, IAPs and p53. While many apoptotic drugs proved its efficacy in preclinical studies, some are already approved and entered the clinical setting. Numerous novel approaches such as antisense the...","author":[{"@context":"https://schema.org","@type":"Person","name":"vimala ananthy"}],"contributor":[],"dateCreated":"2024-08-12","dateModified":null,"datePublished":null,"headline":"Drugs modulating apoptosis: current status","inLanguage":"en","keywords":["Apoptosis","Medicine","Disease","Programmed cell death","Caspase"],"locationCreated":null,"publication":"International Journal of Basic \u0026amp; Clinical Pharmacology","publisher":{"@context":"https://schema.org","@type":"Organization","name":"Medip Academy"},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/122826662/Drugs_modulating_apoptosis_current_status","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"sbvu"}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-352e32ba4e89304dc0b4fa5b3952eef2198174c54cdb79066bc62e91c68a1a91.css" /><link rel="stylesheet" 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Like any other process, it is also subjected to lots of deregulations and can lead to diseases like cancer, neurodegenerative conditions, multiple sclerosis, Parkinson鈥檚 disease, autoimmune disorders and inappropriate death of cells after liver failure, stroke and myocardial infarction. The knowledge of the molecular mechanisms involved in apoptosis has been progressed tremendously. Thus, therapeutics targeting apoptosis have been emerged as a novel approach for treating various disease conditions. Current approaches induce or inhibit apoptosis by targeting the key regulators of apoptosis such as Bcl2 family of proteins, TRAIL, caspases, MDM2, IAPs and p53. While many apoptotic drugs proved its efficacy in preclinical studies, some are already approved and entered the clinical setting. Numerous novel approaches such as antisense the...","publisher":"Medip Academy","publication_name":"International Journal of Basic \u0026amp; Clinical Pharmacology"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Drugs modulating apoptosis: current status","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [51518496]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":117408986,"attachmentType":"pdf"}"><div class="ds-work-cover--blank-cover"><div class="ds-work-cover--blank-cover--title">Drugs modulating apoptosis: current status</div><div class="ds-work-cover--blank-cover--page-count">6 Pages</div></div><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Drugs modulating apoptosis: current status</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="51518496" href="https://sbvu.academia.edu/vimalaananthy"><img alt="Profile image of vimala ananthy" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/51518496/26262827/24856590/s65_vimala.ananthy.jpg" />vimala ananthy</a></div><p class="ds-work-card--detail ds2-5-body-sm">International Journal of Basic &amp; Clinical Pharmacology</p><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Apoptosis (programmed cell death) is a natural process that helps in removing potentially harmful cells from the body and replacing it with normal ones. Like any other process, it is also subjected to lots of deregulations and can lead to diseases like cancer, neurodegenerative conditions, multiple sclerosis, Parkinson鈥檚 disease, autoimmune disorders and inappropriate death of cells after liver failure, stroke and myocardial infarction. The knowledge of the molecular mechanisms involved in apoptosis has been progressed tremendously. Thus, therapeutics targeting apoptosis have been emerged as a novel approach for treating various disease conditions. Current approaches induce or inhibit apoptosis by targeting the key regulators of apoptosis such as Bcl2 family of proteins, TRAIL, caspases, MDM2, IAPs and p53. While many apoptotic drugs proved its efficacy in preclinical studies, some are already approved and entered the clinical setting. Numerous novel approaches such as antisense the...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":117408986,"attachmentType":"pdf","workUrl":"https://www.academia.edu/122826662/Drugs_modulating_apoptosis_current_status"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":117408986,"attachmentType":"pdf","workUrl":"https://www.academia.edu/122826662/Drugs_modulating_apoptosis_current_status"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="117408986" data-landing_url="https://www.academia.edu/122826662/Drugs_modulating_apoptosis_current_status" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="23702316" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23702316/Apoptosis_in_health_and_disease_and_modulation_of_apoptosis_for_therapy_An_overview">Apoptosis in health and disease and modulation of apoptosis for therapy: An overview</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37759387" href="https://gbu.academia.edu/DrNeetaSingh">Dr. Neeta Singh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Indian Journal of Clinical Biochemistry, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Apoptosis in health and disease and modulation of apoptosis for therapy: An overview","attachmentId":44112575,"attachmentType":"pdf","work_url":"https://www.academia.edu/23702316/Apoptosis_in_health_and_disease_and_modulation_of_apoptosis_for_therapy_An_overview","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/23702316/Apoptosis_in_health_and_disease_and_modulation_of_apoptosis_for_therapy_An_overview"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="84143195" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/84143195/Potential_Drug_Targets_in_the_Death_Pathway_Therapeutic_Approaches_in_Apoptosis">Potential Drug Targets in the Death Pathway: Therapeutic Approaches in Apoptosis</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34365066" href="https://kau.academia.edu/MdMizanurRahmanWashim">Md. 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data-collection-position="17" data-entity-id="46960202" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/46960202/Targeted_induction_of_apoptosis_for_cancer_therapy_current_progress_and_prospects">Targeted induction of apoptosis for cancer therapy: current progress and prospects</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35217036" href="https://independent.academia.edu/WHelfrich">Wijnand Helfrich</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Trends in Molecular Medicine, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Targeted induction of apoptosis for cancer therapy: current progress and 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