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style="font-size:var(--wp--custom--font-sizes--tiny);" class="has-text-align-left alignwide wp-block-site-tagline">An Educational Resource for Transfusion Medicine</p> <main class="wp-block-group is-layout-flow wp-block-group-is-layout-flow"><div class="entry-content wp-block-post-content is-layout-constrained wp-block-post-content-is-layout-constrained"> <div class="wp-block-group alignfull has-background is-layout-flow wp-block-group-is-layout-flow" style="background-color:#f4f6f2;padding-top:60px;padding-right:5vw;padding-bottom:60px;padding-left:5vw"> <div class="wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="padding-right:3vw;padding-left:0vw;flex-basis:45%"> <p style="font-size:14px;letter-spacing:1px;text-transform:uppercase"><span class="uppercase"><strong>Featured</strong></span></p> <hr class="wp-block-separator has-text-color has-primary-color has-css-opacity has-primary-background-color has-background is-style-wide"/> <h1 class="wp-block-post-title"><a href="https://redcrossplus.blog/" target="_self" rel="https://redcrossplus.blog/2023/03/31/oh-baby-baby-a-case-study/">Empower Group O Care: An Initiative of the American Red Cross</a></h1> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:100%"> <figure class="wp-block-table"><table class="has-fixed-layout"><tbody><tr><td colspan="2">In accordance with the AABB Association Bulletin, the Red Cross is leading the charge with our hospital partners to reduce O-negative utilization nationwide. We are helping our hospital partners to Start Smart, starting emergency transfusion for patients with unknown blood type with O-positive RBCs.</td></tr></tbody></table></figure> </div> </div> <div class="wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-fill"><a class="wp-block-button__link has-vivid-red-background-color has-background has-custom-font-size wp-element-button" href="https://redcrossplus.blog/2025/03/11/empower-group-o-care-an-initiative-of-the-american-red-cross/" style="border-radius:0px;font-size:14px">READ MORE</a></div> </div> <div style="height:20px" aria-hidden="true" class="wp-block-spacer"></div> </div> <div class="wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:70%"> <figure class="wp-block-image size-full"><img data-recalc-dims="1" fetchpriority="high" decoding="async" width="1000" height="500" data-attachment-id="1097" data-permalink="https://redcrossplus.blog/untitled-design-20/" data-orig-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/03/Untitled-design-20.png?fit=1000%2C500&ssl=1" data-orig-size="1000,500" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Untitled design (20)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/03/Untitled-design-20.png?fit=300%2C150&ssl=1" data-large-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/03/Untitled-design-20.png?fit=1000%2C500&ssl=1" src="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/03/Untitled-design-20.png?resize=1000%2C500&ssl=1" alt="" class="wp-image-1097" srcset="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/03/Untitled-design-20.png?w=1000&ssl=1 1000w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/03/Untitled-design-20.png?resize=300%2C150&ssl=1 300w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/03/Untitled-design-20.png?resize=768%2C384&ssl=1 768w" sizes="(max-width: 1000px) 100vw, 1000px" /></figure> </div> </div> </div> <div class="wp-block-group alignfull is-layout-flow wp-block-group-is-layout-flow" style="padding-top:60px;padding-right:6vw;padding-bottom:60px;padding-left:6vw"> <h2 class="wp-block-heading alignfull" id="recipes" style="font-size:32px;text-transform:uppercase"><span class="uppercase">Articles</span></h2> <div class="wp-block-query alignfull is-layout-flow wp-block-query-is-layout-flow"> <div class="wp-block-query is-layout-flow wp-block-query-is-layout-flow"><ul class="columns-4 wp-block-post-template is-layout-grid wp-container-core-post-template-is-layout-1 wp-block-post-template-is-layout-grid"><li class="wp-block-post post-1054 post type-post status-publish format-standard has-post-thumbnail hentry category-neonatal-and-pediatric category-safety category-sickle-cell-disease category-uncategorized author-barry-siegfried-md author-f-bernadette-west-m-d"> <div class="wp-block-group is-layout-flow wp-block-group-is-layout-flow" style="padding-top:30px;padding-right:30px;padding-bottom:30px;padding-left:30px"><figure class="wp-block-post-featured-image"><img data-recalc-dims="1" decoding="async" width="1000" height="1000" src="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/02/PLUS-Feb-25-1000by1000.png?resize=1000%2C1000&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="" style="object-fit:cover;" srcset="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/02/PLUS-Feb-25-1000by1000.png?w=1000&ssl=1 1000w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/02/PLUS-Feb-25-1000by1000.png?resize=300%2C300&ssl=1 300w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/02/PLUS-Feb-25-1000by1000.png?resize=150%2C150&ssl=1 150w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/02/PLUS-Feb-25-1000by1000.png?resize=768%2C768&ssl=1 768w" sizes="(max-width: 1000px) 100vw, 1000px" data-attachment-id="1064" data-permalink="https://redcrossplus.blog/2025/02/13/biotin-labeled-red-cell-survival-in-pediatric-patients-with-sickle-cell-disease-who-form-antibodies-of-uncertain-clinical-significance/plus-feb-25-1000by1000/" data-orig-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/02/PLUS-Feb-25-1000by1000.png?fit=1000%2C1000&ssl=1" data-orig-size="1000,1000" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="PLUS Feb 25 1000by1000" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/02/PLUS-Feb-25-1000by1000.png?fit=300%2C300&ssl=1" data-large-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/02/PLUS-Feb-25-1000by1000.png?fit=1000%2C1000&ssl=1" /></figure> <h2 style="line-height:1.5;" class="has-text-align-center wp-block-post-title has-medium-font-size"><a href="https://redcrossplus.blog/2025/02/13/biotin-labeled-red-cell-survival-in-pediatric-patients-with-sickle-cell-disease-who-form-antibodies-of-uncertain-clinical-significance/" target="_self" >Biotin-labeled red cell survival in pediatric patients with sickle cell disease who form antibodies of uncertain clinical significance</a></h2> <div class="has-text-align-center wp-block-post-excerpt has-small-font-size"><p class="wp-block-post-excerpt__excerpt">Patients of all ages with sickle cell disease (SCD) who are frequently transfused develop more auto- and alloantibodies against RBC antigens compared to the general population of transfused patients.[1] [2] In addition, chronically transfused children, compared to those who are infrequently transfused, are over three times more likely to develop warm autoantibodies (WAA),[3] which are…</p><p class="wp-block-post-excerpt__more-text"><a class="wp-block-post-excerpt__more-link" href="https://redcrossplus.blog/2025/02/13/biotin-labeled-red-cell-survival-in-pediatric-patients-with-sickle-cell-disease-who-form-antibodies-of-uncertain-clinical-significance/">READ MORE</a></p></div></div> </li><li class="wp-block-post post-1027 post type-post status-publish format-standard has-post-thumbnail hentry category-uncategorized author-jane-ly-md"> <div class="wp-block-group is-layout-flow wp-block-group-is-layout-flow" style="padding-top:30px;padding-right:30px;padding-bottom:30px;padding-left:30px"><figure class="wp-block-post-featured-image"><img data-recalc-dims="1" decoding="async" width="1000" height="1000" src="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/01/Untitled-design-2.png?resize=1000%2C1000&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="" style="object-fit:cover;" srcset="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/01/Untitled-design-2.png?w=1000&ssl=1 1000w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/01/Untitled-design-2.png?resize=300%2C300&ssl=1 300w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/01/Untitled-design-2.png?resize=150%2C150&ssl=1 150w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/01/Untitled-design-2.png?resize=768%2C768&ssl=1 768w" sizes="(max-width: 1000px) 100vw, 1000px" data-attachment-id="1028" data-permalink="https://redcrossplus.blog/untitled-design-2/" data-orig-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/01/Untitled-design-2.png?fit=1000%2C1000&ssl=1" data-orig-size="1000,1000" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Untitled design (2)" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/01/Untitled-design-2.png?fit=300%2C300&ssl=1" data-large-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2025/01/Untitled-design-2.png?fit=1000%2C1000&ssl=1" /></figure> <h2 style="line-height:1.5;" class="has-text-align-center wp-block-post-title has-medium-font-size"><a href="https://redcrossplus.blog/2025/01/14/safety-of-hypoxic-red-blood-cell-administration-in-patients-with-transfusion-dependent-hematological-malignancies-an-interim-analysis/" target="_self" >Safety of hypoxic red blood cell administration in patients with transfusion-dependent hematological malignancies: An interim analysis </a></h2> <div class="has-text-align-center wp-block-post-excerpt has-small-font-size"><p class="wp-block-post-excerpt__excerpt">Red blood cells are the most transfused product in the world and many patients depend on their accessibility.1 While modern additives have boosted their shelf life from 21 days to 42 days, hypothermic storage causes negative changes to the RBCs over time. This “storage lesion” results in numerous changes including a decrease in glucose, 2,3-diphosphoglycerate…</p><p class="wp-block-post-excerpt__more-text"><a class="wp-block-post-excerpt__more-link" href="https://redcrossplus.blog/2025/01/14/safety-of-hypoxic-red-blood-cell-administration-in-patients-with-transfusion-dependent-hematological-malignancies-an-interim-analysis/">READ MORE</a></p></div></div> </li><li class="wp-block-post post-982 post type-post status-publish format-standard has-post-thumbnail hentry category-uncategorized author-courtney-e-lawrence-md-ms"> <div class="wp-block-group is-layout-flow wp-block-group-is-layout-flow" style="padding-top:30px;padding-right:30px;padding-bottom:30px;padding-left:30px"><figure class="wp-block-post-featured-image"><img data-recalc-dims="1" loading="lazy" decoding="async" width="1000" height="1000" src="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/12/1000x1000.png?resize=1000%2C1000&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="" style="object-fit:cover;" srcset="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/12/1000x1000.png?w=1000&ssl=1 1000w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/12/1000x1000.png?resize=300%2C300&ssl=1 300w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/12/1000x1000.png?resize=150%2C150&ssl=1 150w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/12/1000x1000.png?resize=768%2C768&ssl=1 768w" sizes="auto, (max-width: 1000px) 100vw, 1000px" data-attachment-id="977" data-permalink="https://redcrossplus.blog/1000x1000-7/" data-orig-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/12/1000x1000.png?fit=1000%2C1000&ssl=1" data-orig-size="1000,1000" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="1000×1000" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/12/1000x1000.png?fit=300%2C300&ssl=1" data-large-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/12/1000x1000.png?fit=1000%2C1000&ssl=1" /></figure> <h2 style="line-height:1.5;" class="has-text-align-center wp-block-post-title has-medium-font-size"><a href="https://redcrossplus.blog/2024/12/05/group-a-plasma-safe-for-emergency-transfusion-in-pediatric-patients/" target="_self" >Recent Publication on Use of Group A Plasma For Emergency Transfusion In Pediatric Patients</a></h2> <div class="has-text-align-center wp-block-post-excerpt has-small-font-size"><p class="wp-block-post-excerpt__excerpt">With increasing use of targeted agents for anticoagulation reversal and treatment of bleeding disorders, clinical scenarios requiring plasma transfusion have become more limited.1, 2, While plasma transfusion has decreased in the United States for over a decade, use in the trauma setting is an important exception to this trend. After a 2007 study3 showed improved…</p><p class="wp-block-post-excerpt__more-text"><a class="wp-block-post-excerpt__more-link" href="https://redcrossplus.blog/2024/12/05/group-a-plasma-safe-for-emergency-transfusion-in-pediatric-patients/">READ MORE</a></p></div></div> </li><li class="wp-block-post post-953 post type-post status-publish format-standard has-post-thumbnail hentry category-aabb category-blood-donation category-safety author-barry-siegfried-md"> <div class="wp-block-group is-layout-flow wp-block-group-is-layout-flow" style="padding-top:30px;padding-right:30px;padding-bottom:30px;padding-left:30px"><figure class="wp-block-post-featured-image"><img data-recalc-dims="1" loading="lazy" decoding="async" width="1000" height="1000" src="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/11/1000x1000.png?resize=1000%2C1000&ssl=1" class="attachment-post-thumbnail size-post-thumbnail wp-post-image" alt="" style="object-fit:cover;" srcset="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/11/1000x1000.png?w=1000&ssl=1 1000w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/11/1000x1000.png?resize=300%2C300&ssl=1 300w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/11/1000x1000.png?resize=150%2C150&ssl=1 150w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/11/1000x1000.png?resize=768%2C768&ssl=1 768w" sizes="auto, (max-width: 1000px) 100vw, 1000px" data-attachment-id="957" data-permalink="https://redcrossplus.blog/1000x1000-6/" data-orig-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/11/1000x1000.png?fit=1000%2C1000&ssl=1" data-orig-size="1000,1000" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="1000×1000" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/11/1000x1000.png?fit=300%2C300&ssl=1" data-large-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2024/11/1000x1000.png?fit=1000%2C1000&ssl=1" /></figure> <h2 style="line-height:1.5;" class="has-text-align-center wp-block-post-title has-medium-font-size"><a href="https://redcrossplus.blog/2024/11/08/the-american-red-cross-at-the-2024-aabb-annual-meeting/" target="_self" >The American Red Cross at the 2024 AABB Annual Meeting </a></h2> <div class="has-text-align-center wp-block-post-excerpt has-small-font-size"><p class="wp-block-post-excerpt__excerpt">The recent Annual Meeting of the Association for the Advancement of Blood and Biotherapies (AABB) in Houston, Texas, was the occasion for the presentation of reviews and new developments in blood banking, transfusion medicine, and biological therapies. The American Red Cross was proud to participate in this event through posters and live presentations. I detail…</p><p class="wp-block-post-excerpt__more-text"><a class="wp-block-post-excerpt__more-link" href="https://redcrossplus.blog/2024/11/08/the-american-red-cross-at-the-2024-aabb-annual-meeting/">READ MORE</a></p></div></div> </li></ul></div> </div> </div> <div class="wp-block-group alignfull has-background is-layout-flow wp-block-group-is-layout-flow" style="background-color:#f4f6f2;padding-top:60px;padding-right:5vw;padding-bottom:60px;padding-left:5vw"> <div class="wp-block-columns is-layout-flex wp-container-core-columns-is-layout-3 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:25%"> <h4 class="wp-block-heading" id="what-s-cooking" style="text-transform:uppercase">TRending <span class="uppercase">Topics</span></h4> </div> <div class="wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:75%"> <div class="wp-block-buttons alignfull is-horizontal is-content-justification-right is-layout-flex wp-container-core-buttons-is-layout-2 wp-block-buttons-is-layout-flex"> <div class="wp-block-button is-style-fill"><a class="wp-block-button__link has-vivid-cyan-blue-background-color has-background has-custom-font-size wp-element-button" href="https://redcrossplus.blog/category/reds/" style="border-radius:0px;font-size:14px"><span class="uppercase"><strong>REDs</strong></span></a></div> <div class="wp-block-button is-style-fill"><a class="wp-block-button__link has-vivid-cyan-blue-background-color has-background has-custom-font-size wp-element-button" href="https://redcrossplus.blog/category/neonatal-and-pediatric/" style="border-radius:0px;font-size:14px"><strong><span class="uppercase">Neonatal</span></strong></a></div> <div class="wp-block-button is-style-fill"><a class="wp-block-button__link has-vivid-cyan-blue-background-color has-background has-custom-font-size wp-element-button" href="https://redcrossplus.blog/category/blood-disease/" style="border-radius:0px;font-size:14px"><strong><span class="uppercase">Blood Disease</span></strong></a></div> <div class="wp-block-button is-style-fill"><a class="wp-block-button__link has-vivid-cyan-blue-background-color has-background has-custom-font-size wp-element-button" href="https://redcrossplus.blog/category/sickle-cell-disease/" style="border-radius:0px;font-size:14px"><strong><span class="uppercase">Sickle Cell</span></strong></a></div> <div class="wp-block-button is-style-fill"><a class="wp-block-button__link has-vivid-cyan-blue-background-color has-background has-custom-font-size wp-element-button" href="https://redcrossplus.blog/category/testing/" style="border-radius:0px;font-size:14px"><strong><span class="uppercase">Testing</span></strong></a></div> <div class="wp-block-button is-style-fill"><a class="wp-block-button__link has-vivid-cyan-blue-background-color has-background has-custom-font-size wp-element-button" href="https://redcrossplus.blog/category/safety/" style="border-radius:0px;font-size:14px"><strong>Safety</strong></a></div> </div> </div> </div> </div> <div class="wp-block-group alignfull is-layout-flow wp-block-group-is-layout-flow" style="padding-top:80px;padding-right:5vw;padding-bottom:40px;padding-left:5vw"> <div class="wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-4 wp-block-columns-is-layout-flex"> <div class="wp-block-column is-layout-flow wp-block-column-is-layout-flow" style="flex-basis:70%"> <figure class="wp-block-image size-full"><img data-recalc-dims="1" loading="lazy" decoding="async" width="1000" height="500" data-attachment-id="383" data-permalink="https://redcrossplus.blog/untitled-1000-x-500-px-2/" data-orig-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2023/05/Untitled-1000-%C3%97-500-px-2.png?fit=1000%2C500&ssl=1" data-orig-size="1000,500" data-comments-opened="0" data-image-meta="{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0"}" data-image-title="Untitled-1000-×-500-px-2" data-image-description="" data-image-caption="" data-medium-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2023/05/Untitled-1000-%C3%97-500-px-2.png?fit=300%2C150&ssl=1" data-large-file="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2023/05/Untitled-1000-%C3%97-500-px-2.png?fit=1000%2C500&ssl=1" src="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2023/05/Untitled-1000-%C3%97-500-px-2.png?resize=1000%2C500&ssl=1" alt="" class="wp-image-383" srcset="https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2023/05/Untitled-1000-%C3%97-500-px-2.png?w=1000&ssl=1 1000w, https://i0.wp.com/redcrossplus.blog/wp-content/uploads/2023/05/Untitled-1000-%C3%97-500-px-2.png?resize=300%2C150&ssl=1 300w, 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