CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "www.tandfonline.com",cType: 'managed',cRay: '8e9346277ea1448f',cH: 'B7LVpVn0SJ5mHjE2iZlvcMunp2szhJYG9G9OInOpDZQ-1732722627-1.2.1.1-M0tuTcMQjvekmPSin_vr2pLNlbW4yWqapzM8nLREIaLMXNpbTTLnsXrHIY5_gZve',cUPMDTk: "\/doi\/pdf\/10.4155\/bio-2024-0024?needAccess=true&__cf_chl_tk=iYLKJTni5bhOTNy9LguiOTz32L8PR9i5_l3qoIcGJYQ-1732722627-1.0.1.1-gYWRIbPLNgfVKxyogpAqVZI2eYooUDzxx_2mpbbDrCg",cFPWv: 'b',cITimeS: '1732722627',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/pdf\/10.4155\/bio-2024-0024?needAccess=true&__cf_chl_f_tk=iYLKJTni5bhOTNy9LguiOTz32L8PR9i5_l3qoIcGJYQ-1732722627-1.0.1.1-gYWRIbPLNgfVKxyogpAqVZI2eYooUDzxx_2mpbbDrCg",md: "Lq6Nhma0dBJkRLBamAhxMpv73FNuT1B7.bXvlQvFgYI-1732722627-1.2.1.1-5N5GkLiPbM00w8hGtpCH8ytmwL9Cju9Cp5KNCTE1Qze16sDuOpYfX48yXCOJJtNtoCFdQXx0xvRQVarP1ttThbOVMl2MkinVcHSFpmRtJODu.YdhpLo9wR9mfxxjK_OYJnlu8Gqeex2GrvVkleb2cYbAT4VUCzv7vdNq051rjCL4JdjfQWbCqz12waixmz2qarrmUizMrV.amd7l52FCeVLTV6YoD.oIHQhvng4z0s8QrvHHvmBxybCR76_fBaaC8YldMTBVkRAx5OWF21ikqqIb32rJBHTLfpprFDp3B6oU0LMnjcW6WZSM8dsGEe2pVKJHosOaSQqcN4T3FsOEIOTgzspm.xSDfzCSgGvV1OdZ_SdVkWhoyYC0BxFYTUkNZyiGUnMSHazmH18a0BTXjrjHPu0F16LN9cOFdyaIWJV7vqbuC95KMxGmPS1G9pvUO15Rw0sKpKhFt3KwKwAyk11WGILJhFdsuuFWNmrjfEg6GUl5JWwA_lvqGcu63rPpXOAOJZHNSVFxMr5an7iAJ__O0HWe3BUGoOWKEvBCYPTZcU3TpI1LzDxh8Fkv1N2Z3Z2CtQ570cnKxH6dJFwb8saKox8c51NGwfaElrIGH52joOzuEEinFTOyFdkukdsA6JmRvu9kDSupjx318C.sSgVBeNDY_v3JBTa8v2Vs3Z6BqSG.6lOWE9iTvV47HnCrih3ueH0gAPL8HuqpIPZMAYUxhtSO_DxW7Gqj55hQA2pX6NMbH9HAzvlUK6YE2SwBHlVUg3IEipeB3Y2yTQzQ_yEzTt4r8LqUICOW8osfF_Qg2uiM1UBzjlkPq02yTLCvZsVUmGyLAN3wPy6p6VVj.BR54qQ8_AjkAYSNCpoEydxO34xqvECLr91bNqt8eE99ILbRbKH1ZSUfdcObjRi9P0AhQrppI5JDKmbvcGo7jGvVmsi2rBzVCzunJTjhJWiZe2lIhZqXaubDZJuIAPiU6QUad50i_ktNrFYY7pVB2_0J6nC_gtX5n5BGdwDGzRbcIOWrU_PblQlJsiNH4jQBf5CHeJy.743TYLEYs.pNGE20bE1vf2381zEIJUCtEPP55shSypuN_RJ8.2ju157fM_UIo4LBN6Ckm_p.51dSjNXm2a1zW_jWsjduWQP0GwOnCmdc360hujLK5Mj_m6QK3e.XDI4P.MRC6W0FymN4BC0.F_loD6lXIsxFT.EpVWYHjf_E_xQ8CjOCs.5MJ4nCEjE6lhovXcC8aFm4dsUdeWSeMPLEtgEavyDMTQ9BNOrFX8c8vz0gOU0bzsEci5QBaXBApB7LBE7OH2iMoKoDf4LrH.qNBP0Owod0k3oL7NE01ZVYMCPBqoUDbhkhgsnXYW99Ed03k5oCykjzin4wcjbBXwPyJKgBsWwGZUbajtSUua_xTXFn8UhKY83vYi.4lqBlAXY.cZ6orWDp.6EUecTm0jT8G4lbmhq6gycRkKMnqpl7HW4xn5hv0S0JAqS4to_VVj1iqSoRdh.2iAJi4udYJxnsSOu56GQH2a52VbC5nR0ZC69Di4vid.SDS4fFsmP7X1xSEtgTzbaOVzttwADh0QHVN9nDMIL_WMjdER9zY7gfUDa7r79lvGLaPT0mHjQxNcDUxM1qHck_e9v_YvKh8WG4wXOme_LOF3AIdatTarv0mtQSocgbb5ZM9V2Atss3v7O6KSSZ3Ws2eoaHOC7bZT5dYB.6CxH9a.4azrz01aVzllMFzIjkvl1vY8etTXbuAh_OJ_NPLTjRnBJCBWlzznl6tBzaXknVy5M81GZ1bUb9iRjJz.7AyNkHeL5gQCbzB5n6m9MOPQl1wFQRvYlxmOfW59whyYExwHJhU7Gf6y6N7OA8ZjlMvxu_l_QkVdAJeBamHx_at3D6e6jBpexlKxOqwFcHfBpRbUZSEvuf4wiV73nRTU9tkEGt18VKQlFW_3Czsm5HsDnOcrHtF.g1T9L56yzEGGIi76OfI7tVXG049IZCqWtH4_ThVwZnubFhFoEoIT69EJk7CCN5EP_J4GqvonInM.4zXANlD6DiFCOyv5LdSaK6UNLg9yT_y2Vpur1hfJJfJrqylEqKvJQWE1bXtSEffuiRfKAYvztLIdQdOuFlm3unO.aTNTa5wnBbHj4UFUTpaOXbc2knyPwaTuFx5sz6QL0I0XHm9a2TDSrA4nar2B4lZnQNGxgSVJfJKpMSesItE1rObRBowBAWNLlRo16lMMrlOvzWn3Lir0CprB3BP6VvfYBv.R1qddhUCROe9Ojn7fWcfwxozIQPrB3hiuNNr.p2lZLYh500_aqMyQTrMA4VlyAX5Ea.0sTke6h07yorNJiINomtWVKgdXIuGV4OsgbsLtDQtaMBCM3kZXTQTh5ucLzEZdXBQ81tjFGTotHUp94PwpJ.gGg1JHoHO7s_sCj85xTqzFgAMZT3UYkEftgFdcSFWOeXpCM4hu6yiRXOVa.0AG7dnqbjNLyOQe4QqZ5_T.VnmHZ33R5IjfMvol6STu2FFktn58abHJB56SKv3kHmtCYVJ3cPz0wOZYH8u.3JWi3dyRV4jsgFIue0vjXl9s7KeINDmqL0qIjk6xko3j_j.E0RHNmP47YdqzydBtoxHrMLoCsa.PNr4oA0XudczuDllZRQNsw57UDwPAGu8Ya5wDdArFVWlakI8BWjIFP339CvdfBHj9VSrUUEvdlvjzpYZ.iVxarKiVXBml_gVhNIjfS93q36fIGpBGIPNF1T8Cc4qKTZXpX0ZB3Uj.cNExA6iRgPz99v61XKHpXiLJ463L4.yjkDENo46kfp8BRTrbIWgTL7mS2JHVjxOxF2uG0hT_i_cwTyCfq8gM2GccXF1ixRguMF79taS_wMbvrd8dmESPGM9oSFaer96FkfEcqE77tuHMP5VVWM6cQM2V99xImPViC1W8k.SgOZpvOtJGadis1Ve6zlcWqhu1iugip8dspI2S4tlpWIVBialcQt6mX5g6KGVjKGig3Ejf6gb9VPdrzhJWQViXeSdiBggRym5AKrS7KBee0vLdXirAn9Q4funiQ",mdrd: "wE_TPcbTbF_bSGCMdYAqDUxDi8oXjbaVevW3B17qhPI-1732722627-1.2.1.1-t1n5uh6aGYGk4x6Hh16kzjQ.Gtjsdj0Mn9HaMAnCBH_uf3fDsYLyb4y9codVKdp0PwRTPy_d4JLp4f7Vj2itq0_K24IBomdAdx4PjUHv6.ETEw2Jl02mQFX1z13aqW3HURvr1nN2K8VWYFhZ.zHEVrY9S1ALp2h7qrGP7OlC0WBzLYRV8wJqTG.7LKveJEAUbo3Tk6bUvKI_GC99A3Rwmw5wy0_qHUR4SOtFVdi6v4qLOwlH319iWFMX99G1cIOih7r0gDtr.KIX.FNkxDNH5ukWKABIKrMJx6OxufYCXQ9COWYFNEPBAq8P9HMh9hTYaQ6O0d6gBxs8RVOirwLLAXquJbVkNCxEiomFvaVgLyj0MnM8fMWFKkTFBDJaPG.ffQ1lG0nHFREVCRHmbJloNWg2UuT6p76YcP401UUegMs4ezOdtZThCweK7TmPWe9pbv2Sr5KvZeVO3RYX4t_DvcMh8.73ZWtgyhDDCpHUFNlQUx1zh4pQDTXm8osmuYINEtwmLq46JabXSlqVfbq9kBMBC0LYo2bJ2RzC5MyC5Yl6lWnzXwCx6ruMbp.5tEVDHq2.8trD47hWdo7Ugp4JyMVwBYw3TktvE94V0cgknx8Iy1MQxXpwITmH1NJUlnOBfJbUomfu05rRz5S960pw7vKxmvFFlLfFY5cEmqx9V5SucIVRQNkKkvuww6uJEv7fBEs.WDZsycUm9_BpstDUvgYkcc1W4uBgocuYY0Mtq2afq8OBB8AmFZB2a_0noZd68C3MdIiwTRTLD4iNg6a5CTkQypdZOIXKXSU.HRD.F6sJpv3nKAaHPxN6N07rl8QxdsS9u9ObJayUmnrjuVdklYapF_fk0zUB2s8gEg9DPdQohQkD7Z1Vwoa7SSkgI2cJfdJJNgUiEzmgzqkMYmuqEhaCCrowRRmJ_wXxEaTwQ.9pQ0YGJxl4b3IXLEwUT1oz1jfZErVdl0KHL0fczISIaxayfxQ2SeHGDwxnnpuPxxrnuH0kj6uXN75eowHchfDk7QaCLlLQwYrju35x8VnySaEjekwO4FXzS77rvAxPS1cchS7nWHFqaHxXZGcH.LqIClXXq5YR867G.T8CA4UQvtzwTFy4JhTma0X5.f_LQcw637YflyuZnarinUwKB34GPcEL1Mvj2EEHKQoUj4gRGwMU0XXsXARyY9qsiIqyIjn0oqhdERI96I131unqM2bg1EWGXUf8_bp.g_FS408EEbttGZs4Gb9GxKzP7orp1fId7rjhpQjCx0ShwQp_hMjStFx1fiwWFo9eIwdUljjZjZcxfFAx99sYAYg8fvRejh0abyrz9d0.x7Aw30u.V7QdpiVkJX6V50garr12dgI4e4XLWphfgL6nQhSZsVNOCEAqQ1St.lR44XnE9k7bme4j4WDC6ktSbNJQHLDJqKiurB5lzLPr1Vby3dam_ck0P6mZCkWsr9hSTiuf1k0jKOnFwoOT.jCeD24E_s8Wf8xJPZCw2o5gr8OFMDEZb3h19cItTLWezJ64UpZM_Q_7BgVlWMbunEfc_f9NOXADRQ_9S4EnOIUvhdx9acSxF9hLr0VdMpFIuuG75m1EV0Wj5Zb0CM5syb.TeSkfQ3wa2EVsYdiK6Kma2ECQ7QMb27BP.UhOyVLXSlmoy4qV2ENV9O4QLImYP.riInAPWV3rosLylhquS43n45t.vKhSZLi4M4wQISYEEojClTrzVbMsDiCNMG0C6LCYOA2D4LfACbt_AddMsjDy9rbJK5bPdMcGHPlZQYBWKAtXbzGYrJhNc2MJXwtfSwagaVGiDJYOA6Al9TcWjvUI5mSBiwaGYMVHdDh51j0rJ7DiEiGkROo5BlfRYXaXbzm59Y1MpNzHSxy.lSpJtFPCyc7Xsf.jptKEfda3ncG86GOK7ATs7QWpy4hql.mURAKrQBnKiX8XFIegAt7k5pPz0RNxRg8pdNXURAic5ce9phyUZtm8p0lGo22F"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=8e9346277ea1448f';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/pdf\/10.4155\/bio-2024-0024?needAccess=true&__cf_chl_rt_tk=iYLKJTni5bhOTNy9LguiOTz32L8PR9i5_l3qoIcGJYQ-1732722627-1.0.1.1-gYWRIbPLNgfVKxyogpAqVZI2eYooUDzxx_2mpbbDrCg" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>