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Diese Zellen sind terminal differenziert, d.h. sie können sich nicht mehr teilen und so regenerieren oder geschädigte Podozyten ersetzen. Bei den meisten Nierenerkrankungen beobachtet man einen fortschreitenden Podozytenverlust und das diese Zellen trotz ihrer terminalen Differenziertheit wieder in den Zellzyklus eintreten, diesen jedoch nicht bis zur Zellteilung durchlaufen können und stattdessen zu Grunde gehen. 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