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Bridging Genes and Biology: Exploring Neuroimmune Mechanisms Behind Synapse Loss and Dysfunction

<html lang="en"> <head> <!-- CookiePro Cookies Consent Notice start for neuronline.sfn.org --> <script type="text/javascript" src="https://cookie-cdn.cookiepro.com/consent/"760f75b9-29b1-4959-abf2-900a95e073e4"/OtAutoBlock.js"></script> <script src="https://cookie-cdn.cookiepro.com/scripttemplates/otSDKStub.js" type="text/javascript" charset="UTF-8" data-domain-script="760f75b9-29b1-4959-abf2-900a95e073e4"></script> <script type="text/javascript"> function OptanonWrapper() { } </script> <!-- CookiePro Cookies Consent Notice end for neuronline.sfn.org --> <meta charset="utf-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="viewport" content="width=device-width, initial-scale=1"> <link rel="stylesheet" href="https://fonts.googleapis.com/css?family=Roboto:300,400,700|Open+Sans:400,700"> <title>Bridging Genes and Biology: Exploring Neuroimmune Mechanisms Behind Synapse Loss and Dysfunction</title> <meta name="pageID" content="2f2af9c5-2eb4-4dfe-845a-a1fcbbf4e5d4&fo=2f2af9c5-2eb4-4dfe-845a-a1fcbbf4e5d4"> <meta name="description" content="&lt;p&gt;This session will outline paths to define microglia-mediated disease mechanisms, highlighting new models and approaches that bridge gaps between genetics, cellular states, and function.&lt;/p&gt;" /> <meta name="search_importance" content="Normal"> <meta name="search_exclude" content="false"> <meta property="og:url" content="https://neuronline.sfn.org/scientific-research/bridging-genes-and-biology" /> <meta property="og:title" content="Bridging Genes and Biology: Exploring Neuroimmune Mechanisms Behind Synapse Loss and Dysfunction" /> <meta property="og:description" content="&lt;p&gt;This session will outline paths to define microglia-mediated disease mechanisms, highlighting new models and approaches that bridge gaps between genetics, cellular states, and function.&lt;/p&gt;" /> <meta property="og:image" content="https://neuronline.sfn.org/-/media/Project/Neuronline/Webinar-Images/Promotion/2025/2025-mte-beth-stevens-750.jpg" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:title" content="Bridging Genes and Biology: Exploring Neuroimmune Mechanisms Behind Synapse Loss and Dysfunction" /> <meta name="twitter:description" content="&lt;p&gt;This session will outline paths to define microglia-mediated disease mechanisms, highlighting new models and approaches that bridge gaps between genetics, cellular states, and function.&lt;/p&gt;" /> <meta name="twitter:image" content="https://neuronline.sfn.org/-/media/Project/Neuronline/Webinar-Images/Promotion/2025/2025-mte-beth-stevens-750.jpg" /> <meta name="primary_topic" content="Scientific Research" /> <meta name="topic" content="Scientific Research" /> <meta name="topic_path" content="Scientific Research+"> <meta name="type" content="Webinar" /> <meta property="og:type" content="Webinar" /> <meta name="Collection" content="Meet-the-Experts" /> <meta name="primary_image" content="https://neuronline.sfn.org/-/media/Project/Neuronline/Webinar-Images/Promotion/2025/2025-mte-beth-stevens-750.jpg"> <meta name="speaker" content="Beth Stevens, PhD" /> <meta name="audience" content="For Advanced Career, For Chapters, For Early Career, For Independent Researchers, For Mid-Career, For Trainees, For Undergraduates" /> <meta name="faq" content="NA Scientific Research" /> <meta name="publish_date" content="2024-08-30" /> <meta name="start_date" content="2025-03-05"> <meta name="end_date" content="2025-03-05"> <link href="/assets/Neuronline/css/bootstrap.min.css" rel="stylesheet"> <link href="/bundles/neuronlineStyles?v=YVOFc8sKR1fh2LEF68tQ2p9fs9LS--RNoRVk38fzkUc1" rel="stylesheet"/> <!--[if lt IE 9]> <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> <![endif]--> <!-- Google Tag Manager --> <script> (function (w, d, s, l, i) { w[l] = w[l] || []; w[l].push({ 'gtm.start': new Date().getTime(), event: 'gtm.js' }); var f = d.getElementsByTagName(s)[0], j = d.createElement(s), dl = l != 'dataLayer' ? 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<div class="icon"> <img src="/assets/images/neuronline/icn-attend-blue.png"> </div> <div class="date-time"> <div class="date"> March 05, 2025 </div> <div class="time"> 1:00 PM - 2:00 PM EST </div> </div> <div class="cta"> <div class="cta-inner"> <a href="https://my.sfn.org/Events/Calendar-Of-Events/Quick-Register?Meetingid={2E018720-9F2D-EF11-840A-000D3A58F8D5}&amp;eventId={2F2AF9C5-2EB4-4DFE-845A-A1FCBBF4E5D4}" class="btn btn-primary btn-sm" rel="noopener noreferrer" target="_blank" >Register Now</a> </div> </div> </div> </div> </div> </div> <div class="row"> <div class="col-xl-8 offset-xl-2 col-lg-9 offset-lg-1 column-main article-body"> <!-- UPDATE THIS ACCOUNT BEFORE DEVELOPMENT --> <script type="text/javascript" src="//s7.addthis.com/js/300/addthis_widget.js#pubid=ra-53d937761c013c09"></script> <!-- Begin Body --> <div class="tab-content" id=""> <div class="tab-pane fade show active" id="A_e259b9121e094a3f8528e25039ec394b" aria-labelledby="A_e259b9121e094a3f8528e25039ec394b-tab"> <p>Emerging genetic studies implicate microglia in Alzheimer&rsquo;s disease and other brain diseases, yet it's unclear how they contribute to cognitive dysfunction. Microglia eliminates synaptic connections using molecules from the innate immune system, shedding light on mechanisms of pathological synapse loss. This session will outline paths to define microglia-mediated disease mechanisms, highlighting new models and approaches that bridge gaps between genetics, cellular states, and function.</p> <p>This was selected as a part of the Neuroscience 2024 programming: Theme A &ndash; Development.</p> <p><em>This session will be moderated by Michelle Gray, PhD, 2024 Program Committee Member.</em></p> <p><em>Registration is open for all upcoming webinars. The webinars are complimentary for SfN members and $15 for nonmembers. Activate your account to receive member access to webinars.</em></p> </div> <div class="tab-pane fade " id="A_ed74f5192495467eab4c6b71681fd467" aria-labelledby="A_ed74f5192495467eab4c6b71681fd467-tab"> <div class="article-speakers"> <h3>Speaker</h3> <div class="speaker-item"> <div class="image"> <img src="https://neuronline.sfn.org/-/media/Project/Neuronline/Webinar-Images/Speakers/2025/beth-stevens-120.jpg?h=150&amp;w=120&amp;la=en&amp;hash=421CF62DA2DACDA3E22681E10D8923D369D9B6D6" alt="Beth Stevens headshot" /> </div> <div class="content"> <div class="name"> Beth Stevens, PhD </div> <div class="biography"> Beth Stevens, PhD, is an associate professor at Harvard Medical School in the FM Kirby Neurobiology Center at Boston Children’s Hospital, an institute member of the Stanley Center for Psychiatric Research at Broad Institute, Howard Hughes Medical Institute investigator, and member of the National Academy of Medicine. Stevens received her BS at Northeastern University. She carried out her graduate research at the National Institutes of Health and received her PhD from University of Maryland, College Park. She completed her postdoctoral research at Stanford University with Ben Barres. </div> </div> </div> </div> </div> <div class="tab-pane fade " id="A_bbd8d478173c4180bb924699d907b9fb" aria-labelledby="A_bbd8d478173c4180bb924699d907b9fb-tab"> <p><strong>Who can attend these webinars?</strong> All webinars in this series are complimentary to SfN members. <a href="https://my.sfn.org/Membership/Join">Join</a> or <a href="https://www.sfn.org/membership/renew-individual-membership">renew</a> for access. This webinar is $15 for nonmembers.</p> <p><strong>Will the webinars be available on-demand? </strong> Yes, all webinars will be available to watch on demand after the live broadcast.</p> <p><strong>How do I access the conference on the live day?</strong> After registering, you will receive a confirmation email with the event link and the option to download calendar reminders.</p> <p><strong>What are the technology requirements for attending?&nbsp;</strong><span>These webinars are hosted on Zoom Webinar. Instructions for joining and participating in a webinar can be found&nbsp;</span><a rel="noopener noreferrer" href="https://support.zoom.us/hc/en-us/articles/115004954946-Joining-and-participating-in-a-webinar-attendee-" target="_blank">here</a><span>.</span></p> <p><span><strong>Can I ask the presenters questions?</strong>&nbsp;Yes! You can submit any questions before the webinar through the registration form. During the webinar, you can submit questions through the Q&amp;A box.</span></p> <p><strong>Will a certificate of attendance be offered for this event?</strong> No, SfN does not provide certificates of attendance for webinars.&nbsp;</p> <p><strong>I have other questions not answered here.</strong> Email <a href="mailto:digitallearning@sfn.org">digitallearning@sfn.org</a>&nbsp;with any other questions.&nbsp;</p> </div> <div class="tab-pane fade " id="A_ac3775a55e11455b81d15c61e04c76b3" aria-labelledby="A_ac3775a55e11455b81d15c61e04c76b3-tab"> <p>Review <a href="https://www.sfn.org/about/professional-conduct/code-of-conduct-at-sfn-events">SfN&rsquo;s Code of Conduct</a>, rules for virtual events in the <a href="https://neuronline.sfn.org/community-guidelines">Digital Learning Community Guidelines</a>, and communications policies regarding dissemination of unpublished scientific data, listed below. 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