CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "onlinelibrary.wiley.com",cType: 'managed',cRay: '8e7473808ae2a082',cH: '7ZTUIVtwFNSivthp9O2bdbjp2iIFIOj_4kF2kFhrPaU-1732399426-1.2.1.1-7mHY4MEG2XVn4jIqunJew3Yq_xuTVj240L_V1pOthZKzAQv51ToMSEuRKFTxv0EF',cUPMDTk: "\/doi\/abs\/10.1002\/jnr.20546?__cf_chl_tk=1rpi6CqltRlYtm1rwU_itsT1YiVg67SS_UwylpmbN80-1732399426-1.0.1.1-dFUAVfuvV2v_A43kisWfqlo3ESPdIDkeJLwW3e6DpL0",cFPWv: 'g',cITimeS: '1732399426',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/abs\/10.1002\/jnr.20546?__cf_chl_f_tk=1rpi6CqltRlYtm1rwU_itsT1YiVg67SS_UwylpmbN80-1732399426-1.0.1.1-dFUAVfuvV2v_A43kisWfqlo3ESPdIDkeJLwW3e6DpL0",md: "po.5Ob3RopoI3ipntuzPYr2YPRAX3Nx.Ox1y58JB6Ec-1732399426-1.2.1.1-STfHECWvuQuZllu5RZXNX4b3Wo3ndzbIx1rZjqDCnEdDltR4dZ.JaFxKaeHwfHdyBxVZjGI8n_4Iov6pZFRp8CC2OJU1QedWerne7cEUXyWanDEZbrt1dP3Oq0byEh2psRIrx8G_owEtV26Bz92ovfbCEsreRMMSYb.yX4dudzli7y_VRCD.NCar2h6Njq9DN5O9IOZQI9qJHa38TFBuVUEZfZjODfj9hY5gGualQdiVLNrfzwy8O8wP8ErSwyf9sgyQweseTyCDyjLnupRqxysh4zSkMRztIzT2o_OHJBJCmW4K2porIjAC0ogs1W9oPXMuQDREFF5Wp1QbDzSTJQ.Ufcv.QNakdln7WCc72e6Z47d1yMjFYyxexlh.VH_kxLAK3e2E3KglRz3OqClvNL7xYLEdUOVM2jat9Jy89y_V_BL26_CuCgEPXUS3FS3mSFu7nBmqxIqXWw6XrOibzT6TsuQoBLARmJRt6soyEQoXH71WYmVNWOLqVMpWCvsAdhGbiSFOcfD57e4ke0vNkJNg9qs3.H6ZMXGVfYwX_mq3MXPpAfp3UpIBuJZ2xSXD8Frz0m6Go_jyjFlLWYISJeWtdmxWtWn5XyvW79d3k30sIfXKiP9reXKiPncTobjPHgP_liLkffSyt6FzkwHe0KhFSdNt4gSrny3VkJ2xI.Cw3I2xmu3ds._8rNi.dBdHp2kzvd7AmfLl3qC_qFnA4UfFuYuAINb.ehC0HNpuTL5Zy4Hp8fG4Y3mL6rTyWguqT6._cvWjxwh1OaolRiznL8EkXGvWerflv86jewarWL8ABAlzVd1vQmeM0Lg55ppcEO3Ob7MzzuuqZYgOCprSNvDRHfuFjjI8A0vVgl7XKUBOSNo_P10XvKg__HA8qkut6xPG_VkGTE5yZiohS1jXuD0tlbxOK1uHoA83s17nEqKcRW5z043LLjbcRgr4FtNyVOQVcPSSqF6MUxx1Tzgt6b5bGXJDP2vleC8TAGVBrq2ca9il.YAhF3vGxYnKDPc2q75Hw7EkpqCGk5cz2veK2l4p9tkftqhsjMgLZ3jRU6OxESVqTfHn_jPCGejQg5Uai7j47xqX1laUUeTCbsTx_I.p7ZteHb9o_qSfEPfC9u4lnjKOgwsoHE54BmFNWaV4uaHymTbe3Os0maWrN6mKWQ7ToBYo5iJa0lqIprP36xCRyWRSWedYWZwZ.IL0MOldh9yBut.fXkjW44JHxwn9OSdySWWNJzVgvLBh3U6pHWBJK0_3BeCHsXbtFPhZo_pBVaKzMbxJoUVFDVYJgw..bXDTEc3w9VfXNiVw.GziC6L_Qj.hHLmjIDHVyL5uI65a9RSQ0zNcPpyUfnpypYytaCdP9zkzWafGmY3chBVdq1S1xljdbwZiDsLpSm3LwjRn8N24pBciFq9zRWP76u00VxoqlBxuR1gSpd2wh5yGbQyKcWuXEXX2qVVhMtswfh35X8Wks8n9b_iy5GDOFbsrhjpm4eZ3K3UQoVmf8pp2nDkflEfN08SUSqIlaQ_2QaseqM6.dzGh_rkao7KmkHlcptupSdnVOvuSA2YYDnWI.P3bXsOkIDi1AFCVd9IYhQj6BWv8ZeRiAaHer6Kdi.aiDrOqhiRJ6OOECOmocOo_yiMpYoXiDIwfdelVh6jy69q1DBufAlUQvZgdxNtUZNb_LD6noC2Z8PuYW6a7QpjmC9a29x1tukAFUpreE3.BZ6A4fINmYQ4cncwedSWVsdZn2e0uhkkZiFUeAGnVSo278QTwozWhEZKlODMS0SPY4uMZtwqvXISqUge6dtEkNMcicf7Sycv72nZLURHER7OdW4uJifzrYkv1e_wU2Y1vNV5OmmN2NFSIUR9b9qHBtSIbfpT6zWHc9hguZwKWg0_n_Rl75N.gTGDyE8R1TfYZvgbgjG1dfzFm3EhCPQ9tZecLgRn8qNsqvH37i9ysarQAVfz.7mybuH2n0sUR4VsHlubE1LCRi0w.iNgWA1OKIVhKdEn0ES8aXlGVw2g9HjTNdCLux7a5mMBSjDVFhiFCWzMI8fDJuJQ5_x24oKBbj1a7bdTSAKjX3r1bO3DkXtvfD4pHZmgBxTqu06FOcwqbn0vPqRmxQiOpl8amucmTSY3_PTVAYijeL2KN2UGMfeVYxOXfycIdy.cJ28mrU6bVEjTngiXdJBGW1VONS_Z3oZy4iEwZ_4Ypx_92IKR5nj3tgZD73IBzohRJP7h31Q9e04Gu1YJx0Z406pBEuG2bjlqUfGYbTeGnorC.a3BCT_izc5uoze91EWyFKxPt0XAQTzsg1NQqQSIxxoDKP6oNdd0nXnzVM8IEKncbSgvw9OQEtWLXmsJvQjVxax6H8nccfXxKF89YmTqxEw84OzVsZnz8NLS9mxp4r3.7n2gwYHY.vOuWP1QEhymgOVsvLhMbIO3IBSYQPaFcJRCOXN64E3dx9WixMiTY6ABXRSo7k4_fwaoIhOiQu1IZxbemUfG.H4GaEDwHaNkJhzW.DIpo_mYYPhf1gHF8X2JgMWG0E7Zunh9Kd4ibnWTTC1yNSrnEYj77kELEO.qrek9EUfLPb5VbDu9DECO2iPdF9F_JbSkJ2tV742IAq9ZRrVnWZgm9oaTRgLXZjR6VrV13tlTzwSACSy01vFMOMqU0tUb358GD_8ULKY49emAQi.OYF6ut1pUKkTRfoe5cqmmUA1XI029i5czeeRIkS_GccRBTnXlogcnFGhf2Y47Dx6_eAacsE3ZAN_AKAVtbJ2mZ8_ARInimtbFQkzzxPKc_KReAFzYOcgbm6kComL1B1lLEMe6czEjv9oRI5a8bho2g3t1kNEPHgkUGjALl1rAuHEAoZdSRKjrzu9N45qSghp1H2mIFWy40UGyRsf_rXV1huzKjfoyW6A4E95CXQSuWcjc1gBAJi3Xo_fg2K62ldVspSCr8e57Skv1mEANqerPB6CA1iJs1NuD_LApWPlsbERKT1VRoLQQ",mdrd: "n8IHaU3FQ1Su9SLz5A7IzB_KnqR3W6TPqT3jsZ5rVyc-1732399426-1.2.1.1-2FgaR_VjY.kBF0MWnjhWgV2jzxdJ2dphJ5NErXMZ.0NmfyqW_MBbMrq0pbyxzEzWmefKTvVBD0d_lqjqv5vTyFFf8nSmRa.WN_bCgUPbusqF1H.ogtkR_8aPmxlja3aif.wB4oKE8FBzoJa_iIdYjHqYRoZmKuRq56gCgYX_DEpgoDmyyBw1ApFsACrXAzX4G76RxYGrBtVLyDC_owZYM0_qoluZAHzc48CJXvGtGq7QX0j.jIRZ78EynnkOgtf4g_dlG.Bu8XnKaYK.cTucjHAnGo_OVS0PKEHVE_FVTLqmyt3tsKv5oTxjb9X.FBQGJr9J0k.DNrA1HW2.0Cat1AZ7eLh3D_kOYqNlSLzpVpXDI_9Cr9oZ6JojTs7aPOuudCQZ8TKB8UD.K7vkmJZKmXPk5UvvgNnomvtbIEqokslM88RUQh8bkuzmKQcfj6e7D5SSKcHjY0FrcGbvCiOZsWToyrKVkmTzJZhlDyPb2LPxm83ATshqqIlU2U0iJcmQQNI7S7yoOUxzDwHJscyBe2u1GzN0QTVbnCJINXVexfBifat39i3MfX.svN.fdVb.A4hgKvzWCuBvfiNFnrRTioyGijJXrLA8HDwwZkFOMq68SLGR29yjwawP92zafQljBdpI5OcsYi7d12Bj_vW6hSnZdRqiJHdgxcMvZAEB5hY_kEpPhDnpjlYKOKMqWukV6ZaZLHW1NZHFP7znI6QDK12DQMBcB.8o9C9iu.WQZT0fZxGlwD.9ErBRzHccJ4DJqbk3Md31j7zzgjgynsurHe01XX17Q2pYt_.GDe6E64nV4YP6EnPphPoSUxj02xFecdtogHT1psMm1xn0kg5kzRhkYmQPhdcSo94IahL_aoyNd.beYU7Kxhufmcwsfw7P2uqZU8FLznRDfIqOck2_Mmlpz8N8aQJtivFuSVSFgTnc1v6e0yhu1mTURsaiJYhYijLXo50n059z4PPcDqK1DdvCqbmC9F3IRbxFZdFHAhseFClHKuYh4q4VVtqcxihd.dOrHqVcNqQLYqpQwbN4lRMYaCXjzGGJxrSKDfYaPaK3jZVJqYqBuXFJDf7P53v7OCKRSFTDSRM_YG3i7Qwnqm4syFPUH1bf6xOtDBqNwa75n34HROq1Lve4mGiN7kxh35RhyEuGorcu2LWmOjpLJUEp0jk3iyo90ivP1Ux2vOsqPULPURbJGfYU9oBgWaeLogShmrbDkiee2LguFOw58RJB8gc4bJYqBc2OTEaXwpQ_UqYYnJOxNbQ_cVNovHJzQkqmexiHSowwF50VXn8ve7Sf4a5XUmogdRCwPoe726v2uL.f.Ip61bqVaqPnJ3JcPeUxBFUNQzYPUM7.6sJ1m.avgGRRfE7shFKhF48mP71fLBDWUzA2umhm8JTYrEVbk1AKGSn0X3hObBNpdza3NMrXALfkyrzr3j_AsyJQAADQDj3r5YVIqcLhYeFKz2Q6Blhb3_24u2gl..JVAbQbSNYbxxTjEWAANuhxq5fAbES.zGzisK9WyFk9WjP6T2nCLAG8d1qTfJxzwRL5_9Y4z4.3LPvmCOilZnUuJIILI5xBMg1e1SAF_eWT_iPm33kG0QKby_0EnQEwGHNCBMaD0GqN6LQxrS_3Dcz9PDjiqdlb3E7qqkKx2p643tq5rsh3VFC8DKe2pgrnza3qOLk5EJ2h4SAXS0nDrKtaGorYjYi8wuqMpMMgE8r22PXUuN8cQrSFiTzzRR_LV6PY8lHIIRRyh8m4q63Lc9MSejdttkR3ifQBimmy4F5n9AaBKSgUDKuAqFP2h5PfuMvS1B90lj0PoaRalGAP2jDnXExKnOuTbbBT5yV_.rtbs8gDhCCkh9W8yK.D0aQaY9OCYPTv4ANNsC4m1y1i_izxiV.CPTEjPc_svKow3iuAGAzm3yTYbUT3hkgy.ggXRajft3oSe2EE0_7KlM4W62UvoiIysfja3rb4hhfVupxDGtl8ZZK.EgF2f.7_8fakgDqy1gdHPw"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/g/orchestrate/chl_page/v1?ray=8e7473808ae2a082';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/abs\/10.1002\/jnr.20546?__cf_chl_rt_tk=1rpi6CqltRlYtm1rwU_itsT1YiVg67SS_UwylpmbN80-1732399426-1.0.1.1-dFUAVfuvV2v_A43kisWfqlo3ESPdIDkeJLwW3e6DpL0" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>