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Allergens","created_at":"2024-12-03T09:23:31.814-08:00","url":"https://www.academia.edu/126045028/B_Cells_Play_Key_Roles_in_Th2_Type_Airway_Immune_Responses_in_Mice_Exposed_to_Natural_Airborne_Allergens?f_ri=168977","dom_id":"work_126045028","summary":null,"downloadable_attachments":[{"id":119982472,"asset_id":126045028,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33160130,"first_name":"Hirohito","last_name":"Kita","domain_name":"independent","page_name":"HirohitoKita","display_name":"Hirohito Kita","profile_url":"https://independent.academia.edu/HirohitoKita?f_ri=168977","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=168977","nofollow":false},{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines?f_ri=168977","nofollow":false},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=168977","nofollow":false},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=168977"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977"},{"id":38661,"name":"B cells","url":"https://www.academia.edu/Documents/in/B_cells?f_ri=168977"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=168977"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation?f_ri=168977"},{"id":76238,"name":"Air","url":"https://www.academia.edu/Documents/in/Air?f_ri=168977"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=168977"},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=168977"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung?f_ri=168977"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system?f_ri=168977"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes?f_ri=168977"},{"id":1957096,"name":"Jh","url":"https://www.academia.edu/Documents/in/Jh?f_ri=168977"},{"id":2188946,"name":"Airway Inflammation","url":"https://www.academia.edu/Documents/in/Airway_Inflammation?f_ri=168977"},{"id":2200981,"name":"Allergen","url":"https://www.academia.edu/Documents/in/Allergen?f_ri=168977"},{"id":2796077,"name":"Cell count","url":"https://www.academia.edu/Documents/in/Cell_count?f_ri=168977"},{"id":3802935,"name":"Air Microbiology","url":"https://www.academia.edu/Documents/in/Air_Microbiology?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_126045018" data-work_id="126045018" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/126045018/B_cells_play_key_roles_in_th2_type_airway_immune_responses_in_mice_exposed_to_natural_airborne_allergens">B cells play key roles in th2-type airway immune responses in mice exposed to natural airborne allergens</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Humans are frequently exposed to various airborne allergens. In addition to producing antibodies, B cells participate in immune responses via various mechanisms. The roles of B cells in allergic airway inflammation and asthma have been... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_126045018" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Humans are frequently exposed to various airborne allergens. In addition to producing antibodies, B cells participate in immune responses via various mechanisms. The roles of B cells in allergic airway inflammation and asthma have been controversial. We examined the functional importance of B cells in a mouse model of asthma, in which mice were exposed repeatedly to common airborne allergens. Naïve wild-type BALB/c mice or B cell-deficient JH-/- mice were exposed intranasally to a cocktail of allergen extracts, including Alternaria, Aspergillus, and house dust mite, every other day for two weeks. Ovalbumin was included in the cocktail to monitor the T cell immune response. Airway inflammation, lung pathology, and airway reactivity were analyzed. The airway exposure of naïve wild type mice to airborne allergens induced robust eosinophilic airway inflammation, increased the levels of Th2 cytokines and chemokines in the lung, and increased the reactivity to inhaled methacholine. These ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/126045018" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="eb748e3891990a1733987ad085448867" rel="nofollow" data-download="{"attachment_id":119982522,"asset_id":126045018,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119982522/download_file?st=MTczMzI1MjU2Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33160130" href="https://independent.academia.edu/HirohitoKita">Hirohito Kita</a><script data-card-contents-for-user="33160130" type="text/json">{"id":33160130,"first_name":"Hirohito","last_name":"Kita","domain_name":"independent","page_name":"HirohitoKita","display_name":"Hirohito Kita","profile_url":"https://independent.academia.edu/HirohitoKita?f_ri=168977","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_126045018 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="126045018"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 126045018, container: ".js-paper-rank-work_126045018", }); 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In addition to producing antibodies, B cells participate in immune responses via various mechanisms. The roles of B cells in allergic airway inflammation and asthma have been controversial. We examined the functional importance of B cells in a mouse model of asthma, in which mice were exposed repeatedly to common airborne allergens. Naïve wild-type BALB/c mice or B cell-deficient JH-/- mice were exposed intranasally to a cocktail of allergen extracts, including Alternaria, Aspergillus, and house dust mite, every other day for two weeks. Ovalbumin was included in the cocktail to monitor the T cell immune response. Airway inflammation, lung pathology, and airway reactivity were analyzed. The airway exposure of naïve wild type mice to airborne allergens induced robust eosinophilic airway inflammation, increased the levels of Th2 cytokines and chemokines in the lung, and increased the reactivity to inhaled methacholine. These ...","downloadable_attachments":[{"id":119982522,"asset_id":126045018,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33160130,"first_name":"Hirohito","last_name":"Kita","domain_name":"independent","page_name":"HirohitoKita","display_name":"Hirohito Kita","profile_url":"https://independent.academia.edu/HirohitoKita?f_ri=168977","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=168977","nofollow":false},{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines?f_ri=168977","nofollow":false},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=168977","nofollow":false},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=168977"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977"},{"id":38661,"name":"B cells","url":"https://www.academia.edu/Documents/in/B_cells?f_ri=168977"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=168977"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation?f_ri=168977"},{"id":76238,"name":"Air","url":"https://www.academia.edu/Documents/in/Air?f_ri=168977"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=168977"},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=168977"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung?f_ri=168977"},{"id":324154,"name":"Immune system","url":"https://www.academia.edu/Documents/in/Immune_system?f_ri=168977"},{"id":678853,"name":"B Lymphocytes","url":"https://www.academia.edu/Documents/in/B_Lymphocytes?f_ri=168977"},{"id":1957096,"name":"Jh","url":"https://www.academia.edu/Documents/in/Jh?f_ri=168977"},{"id":2188946,"name":"Airway Inflammation","url":"https://www.academia.edu/Documents/in/Airway_Inflammation?f_ri=168977"},{"id":2200981,"name":"Allergen","url":"https://www.academia.edu/Documents/in/Allergen?f_ri=168977"},{"id":2796077,"name":"Cell count","url":"https://www.academia.edu/Documents/in/Cell_count?f_ri=168977"},{"id":3802935,"name":"Air Microbiology","url":"https://www.academia.edu/Documents/in/Air_Microbiology?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_126040725" data-work_id="126040725" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/126040725/Gene_Expression_and_Tissue_Distribution_of_the_Major_Human_Allergen_Bla_g_1_in_the_German_Cockroach_i_Blattella_germanica_i_L_Dictyoptera_Blattellidae_">Gene Expression and Tissue Distribution of the Major Human Allergen Bla g 1 in the German Cockroach,<i>Blattella germanica</i>L. 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hôtes-vecteurs-parasites dans les infections par trypanosomatidae),</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125993745" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="684b67033a20f43cde89384917613dea" rel="nofollow" data-download="{"attachment_id":119939058,"asset_id":125993745,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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respiratory health of children living in the industrial area of Puchuncaví, Chile]</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125992022" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="935b8f8132a448e3880ffe8c0e459116" rel="nofollow" data-download="{"attachment_id":119937688,"asset_id":125992022,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" 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type="text/json">{"id":13530,"name":"Chile","url":"https://www.academia.edu/Documents/in/Chile?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=125992022]'), work: {"id":125992022,"title":"[Acute effects of the breathing of industrial waste and of sulfur dioxide on the respiratory health of children living in the industrial area of Puchuncaví, 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u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125913996" data-work_id="125913996" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125913996/Work_related_asthma_diagnosis_and_prognosis_of_immunological_occupational_asthma_and_work_exacerbated_asthma">Work-related asthma: diagnosis and prognosis of immunological occupational asthma and work-exacerbated asthma</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The incidence and prevalence of asthma are increasing. One reason for this trend is the rise in adult-onset asthma, especially occupational asthma, which is 1 of the 2 forms of work-related asthma. Occupational asthma is defined as asthma... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_125913996" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The incidence and prevalence of asthma are increasing. One reason for this trend is the rise in adult-onset asthma, especially occupational asthma, which is 1 of the 2 forms of work-related asthma. Occupational asthma is defined as asthma caused by agents that are present exclusively in the workplace. The presence of pre-existing asthma does not rule out the possibility of developing occupational asthma. A distinction has traditionally been made between immunological occupational asthma (whether IgE-mediated or not) and nonimmunological occupational asthma caused by irritants, the most characteristic example of which is reactive airway dysfunction syndrome. The other form of work-related asthma is known as work-exacerbated asthma, which affects persons with pre-existing or concurrent asthma that is worsened by work-related factors. It is important to differentiate between the 2 entities because their treatment, prognosis, and medical and social repercussions can differ widely. In th...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125913996" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="12b949342eec40f32c51a8e9641298b0" rel="nofollow" data-download="{"attachment_id":119873800,"asset_id":125913996,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119873800/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="213589231" href="https://independent.academia.edu/VictorBustamante59">Victor Bustamante</a><script data-card-contents-for-user="213589231" type="text/json">{"id":213589231,"first_name":"Victor","last_name":"Bustamante","domain_name":"independent","page_name":"VictorBustamante59","display_name":"Victor Bustamante","profile_url":"https://independent.academia.edu/VictorBustamante59?f_ri=168977","photo":"https://0.academia-photos.com/213589231/72441584/60906354/s65_victor.bustamante.png"}</script></span></span></li><li class="js-paper-rank-work_125913996 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125913996"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125913996, container: ".js-paper-rank-work_125913996", }); 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In th...","downloadable_attachments":[{"id":119873800,"asset_id":125913996,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":213589231,"first_name":"Victor","last_name":"Bustamante","domain_name":"independent","page_name":"VictorBustamante59","display_name":"Victor Bustamante","profile_url":"https://independent.academia.edu/VictorBustamante59?f_ri=168977","photo":"https://0.academia-photos.com/213589231/72441584/60906354/s65_victor.bustamante.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=168977","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false},{"id":56122,"name":"Workplace","url":"https://www.academia.edu/Documents/in/Workplace?f_ri=168977","nofollow":false},{"id":65392,"name":"Occupational 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u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125897786/%CE%B2_Glucan_exacerbates_allergic_asthma_independent_of_fungal_sensitization_and_promotes_steroid_resistant_TH2_TH17_responses">β-Glucan exacerbates allergic asthma independent of fungal sensitization and promotes steroid-resistant TH2/TH17 responses</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Allergic sensitization to fungi has been associated with asthma severity. As a result, it has been largely assumed that the contribution of fungi to allergic disease is mediated through their potent antigenicity. We sought to determine... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_125897786" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Allergic sensitization to fungi has been associated with asthma severity. As a result, it has been largely assumed that the contribution of fungi to allergic disease is mediated through their potent antigenicity. We sought to determine the mechanism by which fungi affect asthma development and severity. We integrated epidemiologic and experimental asthma models to explore the effect of fungal exposure on asthma development and severity. We report that fungal exposure enhances allergen-driven TH2 responses, promoting severe allergic asthma. This effect is independent of fungal sensitization and can be reconstituted with β-glucan and abrogated by neutralization of IL-17A. Furthermore, this severe asthma is resistant to steroids and characterized by mixed TH2 and TH17 responses, including IL-13(+)IL-17(+)CD4(+) double-producing effector T cells. Steroid resistance is dependent on fungus-induced TH17 responses because steroid sensitivity was restored in IL-17rc(-/-) mice. Similarly, in ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125897786" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="120f94d20d7d727ee1503c46bfb9dd45" rel="nofollow" data-download="{"attachment_id":119860191,"asset_id":125897786,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119860191/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42332889" href="https://cchmc.academia.edu/GurjitKhuranaHershey">Gurjit K Khurana Hershey, M.D., Ph.D</a><script data-card-contents-for-user="42332889" type="text/json">{"id":42332889,"first_name":"Gurjit","last_name":"Khurana Hershey, M.D., Ph.D","domain_name":"cchmc","page_name":"GurjitKhuranaHershey","display_name":"Gurjit K Khurana Hershey, M.D., Ph.D","profile_url":"https://cchmc.academia.edu/GurjitKhuranaHershey?f_ri=168977","photo":"https://0.academia-photos.com/42332889/11416232/12733904/s65_gurjit.khurana_hershey.jpg"}</script></span></span></li><li class="js-paper-rank-work_125897786 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125897786"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125897786, container: ".js-paper-rank-work_125897786", }); 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As a result, it has been largely assumed that the contribution of fungi to allergic disease is mediated through their potent antigenicity. We sought to determine the mechanism by which fungi affect asthma development and severity. We integrated epidemiologic and experimental asthma models to explore the effect of fungal exposure on asthma development and severity. We report that fungal exposure enhances allergen-driven TH2 responses, promoting severe allergic asthma. This effect is independent of fungal sensitization and can be reconstituted with β-glucan and abrogated by neutralization of IL-17A. Furthermore, this severe asthma is resistant to steroids and characterized by mixed TH2 and TH17 responses, including IL-13(+)IL-17(+)CD4(+) double-producing effector T cells. Steroid resistance is dependent on fungus-induced TH17 responses because steroid sensitivity was restored in IL-17rc(-/-) mice. Similarly, in ...","downloadable_attachments":[{"id":119860191,"asset_id":125897786,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42332889,"first_name":"Gurjit","last_name":"Khurana Hershey, M.D., Ph.D","domain_name":"cchmc","page_name":"GurjitKhuranaHershey","display_name":"Gurjit K Khurana Hershey, M.D., Ph.D","profile_url":"https://cchmc.academia.edu/GurjitKhuranaHershey?f_ri=168977","photo":"https://0.academia-photos.com/42332889/11416232/12733904/s65_gurjit.khurana_hershey.jpg"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=168977","nofollow":false},{"id":17272,"name":"Fungi","url":"https://www.academia.edu/Documents/in/Fungi?f_ri=168977","nofollow":false},{"id":20212,"name":"Allergic 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href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=125897777]'), work: {"id":125897777,"title":"Influence of dog ownership and high endotoxin on wheezing and atopy during infancy","created_at":"2024-11-27T20:40:30.278-08:00","url":"https://www.academia.edu/125897777/Influence_of_dog_ownership_and_high_endotoxin_on_wheezing_and_atopy_during_infancy?f_ri=168977","dom_id":"work_125897777","summary":null,"downloadable_attachments":[{"id":119860192,"asset_id":125897777,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42332889,"first_name":"Gurjit","last_name":"Khurana Hershey, M.D., Ph.D","domain_name":"cchmc","page_name":"GurjitKhuranaHershey","display_name":"Gurjit K Khurana Hershey, M.D., Ph.D","profile_url":"https://cchmc.academia.edu/GurjitKhuranaHershey?f_ri=168977","photo":"https://0.academia-photos.com/42332889/11416232/12733904/s65_gurjit.khurana_hershey.jpg"}],"research_interests":[{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics?f_ri=168977","nofollow":false},{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=168977","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false},{"id":52438,"name":"Dogs","url":"https://www.academia.edu/Documents/in/Dogs?f_ri=168977"},{"id":62112,"name":"Prospective 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Variation","url":"https://www.academia.edu/Documents/in/Coefficient_of_Variation?f_ri=168977"},{"id":273520,"name":"Ohio","url":"https://www.academia.edu/Documents/in/Ohio?f_ri=168977"},{"id":289330,"name":"Prevalence","url":"https://www.academia.edu/Documents/in/Prevalence?f_ri=168977"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires?f_ri=168977"},{"id":735883,"name":"Dust","url":"https://www.academia.edu/Documents/in/Dust?f_ri=168977"},{"id":1142414,"name":"Atopy","url":"https://www.academia.edu/Documents/in/Atopy?f_ri=168977"},{"id":1312021,"name":"Environmental Exposure","url":"https://www.academia.edu/Documents/in/Environmental_Exposure?f_ri=168977"},{"id":1451915,"name":"Endotoxins","url":"https://www.academia.edu/Documents/in/Endotoxins?f_ri=168977"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies?f_ri=168977"},{"id":1826493,"name":"Clinical Allergy and Immunology","url":"https://www.academia.edu/Documents/in/Clinical_Allergy_and_Immunology?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125897774" data-work_id="125897774" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125897774/House_dust_1_3_%CE%B2_d_glucan_and_wheezing_in_infants">House dust (1–3)‐β‐d‐glucan and wheezing in infants</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: (1–3)‐β‐d‐glucan is a fungal cell wall component, suspected to cause respiratory symptoms in adults. However, very little is known on the possible health effects of (1–3)‐β‐d‐glucan during infancy. We examined the association... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_125897774" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: (1–3)‐β‐d‐glucan is a fungal cell wall component, suspected to cause respiratory symptoms in adults. However, very little is known on the possible health effects of (1–3)‐β‐d‐glucan during infancy. We examined the association between (1–3)‐β‐d‐glucan exposure and the prevalence of allergen sensitization and wheezing during the first year of life in a birth cohort of 574 infants born to atopic parents. Endotoxin exposure was included as a possible confounder.Methods: (1–3)‐β‐d‐glucan and endotoxin exposures were measured in settled dust collected from infants’ primary activity rooms. The primary outcomes at approximately age one included parental reports of recurrent wheezing and allergen sensitization evaluated by skin prick testing to a panel of 15 aeroallergens as well as milk and egg white.Results: Exposure to high (1–3)‐β‐d‐glucan concentration (within fourth quartile) was associated with reduced likelihood of both recurrent wheezing [adjusted OR (aOR) = 0.39, 95%...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125897774" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="204dd1fac3a16b4139e4c636328eb736" rel="nofollow" data-download="{"attachment_id":119860168,"asset_id":125897774,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119860168/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="42332889" href="https://cchmc.academia.edu/GurjitKhuranaHershey">Gurjit K Khurana Hershey, M.D., Ph.D</a><script data-card-contents-for-user="42332889" type="text/json">{"id":42332889,"first_name":"Gurjit","last_name":"Khurana Hershey, M.D., Ph.D","domain_name":"cchmc","page_name":"GurjitKhuranaHershey","display_name":"Gurjit K Khurana Hershey, M.D., Ph.D","profile_url":"https://cchmc.academia.edu/GurjitKhuranaHershey?f_ri=168977","photo":"https://0.academia-photos.com/42332889/11416232/12733904/s65_gurjit.khurana_hershey.jpg"}</script></span></span></li><li class="js-paper-rank-work_125897774 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125897774"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125897774, container: ".js-paper-rank-work_125897774", }); 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$(".js-view-count[data-work-id=125897774]").text(description); $(".js-view-count-work_125897774").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_125897774").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="125897774"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62896" href="https://www.academia.edu/Documents/in/Allergy">Allergy</a>, <script data-card-contents-for-ri="62896" type="text/json">{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="134346" href="https://www.academia.edu/Documents/in/Infant">Infant</a><script data-card-contents-for-ri="134346" type="text/json">{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=125897774]'), work: {"id":125897774,"title":"House dust (1–3)‐β‐d‐glucan and wheezing in infants","created_at":"2024-11-27T20:40:26.747-08:00","url":"https://www.academia.edu/125897774/House_dust_1_3_%CE%B2_d_glucan_and_wheezing_in_infants?f_ri=168977","dom_id":"work_125897774","summary":"Background: (1–3)‐β‐d‐glucan is a fungal cell wall component, suspected to cause respiratory symptoms in adults. However, very little is known on the possible health effects of (1–3)‐β‐d‐glucan during infancy. We examined the association between (1–3)‐β‐d‐glucan exposure and the prevalence of allergen sensitization and wheezing during the first year of life in a birth cohort of 574 infants born to atopic parents. Endotoxin exposure was included as a possible confounder.Methods: (1–3)‐β‐d‐glucan and endotoxin exposures were measured in settled dust collected from infants’ primary activity rooms. The primary outcomes at approximately age one included parental reports of recurrent wheezing and allergen sensitization evaluated by skin prick testing to a panel of 15 aeroallergens as well as milk and egg white.Results: Exposure to high (1–3)‐β‐d‐glucan concentration (within fourth quartile) was associated with reduced likelihood of both recurrent wheezing [adjusted OR (aOR) = 0.39, 95%...","downloadable_attachments":[{"id":119860168,"asset_id":125897774,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":42332889,"first_name":"Gurjit","last_name":"Khurana Hershey, M.D., Ph.D","domain_name":"cchmc","page_name":"GurjitKhuranaHershey","display_name":"Gurjit K Khurana Hershey, M.D., Ph.D","profile_url":"https://cchmc.academia.edu/GurjitKhuranaHershey?f_ri=168977","photo":"https://0.academia-photos.com/42332889/11416232/12733904/s65_gurjit.khurana_hershey.jpg"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false},{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=168977","nofollow":false},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=168977","nofollow":false},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=168977"},{"id":459440,"name":"Beta-Glucans","url":"https://www.academia.edu/Documents/in/Beta-Glucans?f_ri=168977"},{"id":735883,"name":"Dust","url":"https://www.academia.edu/Documents/in/Dust?f_ri=168977"},{"id":1330083,"name":"Respiratory Sounds","url":"https://www.academia.edu/Documents/in/Respiratory_Sounds?f_ri=168977"},{"id":1451915,"name":"Endotoxins","url":"https://www.academia.edu/Documents/in/Endotoxins?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125890411" data-work_id="125890411" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125890411/Shellfish_allergens_tropomyosin_and_beyond">Shellfish allergens: tropomyosin and beyond</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125890411" 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(count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=125890411]").text(description); $(".js-view-count-work_125890411").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_125890411").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="125890411"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">13</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7710" href="https://www.academia.edu/Documents/in/Biology">Biology</a>, <script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62896" href="https://www.academia.edu/Documents/in/Allergy">Allergy</a><script data-card-contents-for-ri="62896" 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Ebo","profile_url":"https://independent.academia.edu/DidierEbo?f_ri=168977","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=168977","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false},{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=168977","nofollow":false},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=168977"},{"id":176180,"name":"Immunoglobulin E","url":"https://www.academia.edu/Documents/in/Immunoglobulin_E?f_ri=168977"},{"id":205464,"name":"Crustacean","url":"https://www.academia.edu/Documents/in/Crustacean?f_ri=168977"},{"id":548813,"name":"Shellfish","url":"https://www.academia.edu/Documents/in/Shellfish?f_ri=168977"},{"id":722574,"name":"Tropomyosin","url":"https://www.academia.edu/Documents/in/Tropomyosin?f_ri=168977"},{"id":1528391,"name":"HUMAN MEDICINE","url":"https://www.academia.edu/Documents/in/HUMAN_MEDICINE?f_ri=168977"},{"id":2200981,"name":"Allergen","url":"https://www.academia.edu/Documents/in/Allergen?f_ri=168977"},{"id":2295489,"name":"Hemocyanin","url":"https://www.academia.edu/Documents/in/Hemocyanin?f_ri=168977"},{"id":4076953,"name":"food hypersensitivity","url":"https://www.academia.edu/Documents/in/food_hypersensitivity?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125890410" 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u-tcGrayDarkest"><div class="summarized">OBJETIVO: Revisar os exames laboratoriais disponíveis utilizados no diagnóstico da alergia alimentar mediada ou não por IgE. FONTES DE DADOS: Artigos publicados em base de dados PubMed e Embase (língua inglesa e portuguesa) nos últimos... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_125843056" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">OBJETIVO: Revisar os exames laboratoriais disponíveis utilizados no diagnóstico da alergia alimentar mediada ou não por IgE. FONTES DE DADOS: Artigos publicados em base de dados PubMed e Embase (língua inglesa e portuguesa) nos últimos dez anos. As palavras-chave utilizadas como fonte de busca foram &quot;alergia alimentar&quot;, &quot;diagnóstico&quot; e &quot;laboratório&quot;, isolados e/ou associados. SÍNTESE DOS DADOS: A abordagem diagnóstica das reações alérgicas a alimentos inclui história clínica completa, estudos laboratoriais, dietas de eliminação e desencadeamentos cegos com alimentos. Recentemente, a medida quantitativa de anticorpos IgE específicos a alimentos tem mostrado ser mais preditiva de alergia alimentar sintomática mediada por IgE. Níveis séricos de IgE específica a alimento que excedam os valores diagnósticos indicam que o paciente tem chance maior que 95% de apresentar uma reação alérgica se ingerir o alimento em questão. Estes &quot;valores de decisão&quot; ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125843056" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="12cd2809ba8e902f9032aa2847246847" rel="nofollow" data-download="{"attachment_id":119813388,"asset_id":125843056,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119813388/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="273609356" href="https://independent.academia.edu/nelsonrosario26">nelson rosario</a><script data-card-contents-for-user="273609356" type="text/json">{"id":273609356,"first_name":"nelson","last_name":"rosario","domain_name":"independent","page_name":"nelsonrosario26","display_name":"nelson rosario","profile_url":"https://independent.academia.edu/nelsonrosario26?f_ri=168977","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_125843056 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125843056"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125843056, container: ".js-paper-rank-work_125843056", }); 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$(".js-view-count[data-work-id=125843056]").text(description); $(".js-view-count-work_125843056").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_125843056").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="125843056"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47258" href="https://www.academia.edu/Documents/in/Food_Allergy">Food Allergy</a>, <script data-card-contents-for-ri="47258" type="text/json">{"id":47258,"name":"Food Allergy","url":"https://www.academia.edu/Documents/in/Food_Allergy?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62896" href="https://www.academia.edu/Documents/in/Allergy">Allergy</a>, <script data-card-contents-for-ri="62896" type="text/json">{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="168977" href="https://www.academia.edu/Documents/in/Allergens">Allergens</a><script data-card-contents-for-ri="168977" type="text/json">{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=125843056]'), work: {"id":125843056,"title":"Abordagem laboratorial no diagnóstico da alergia alimentar","created_at":"2024-11-25T15:25:21.230-08:00","url":"https://www.academia.edu/125843056/Abordagem_laboratorial_no_diagn%C3%B3stico_da_alergia_alimentar?f_ri=168977","dom_id":"work_125843056","summary":"OBJETIVO: Revisar os exames laboratoriais disponíveis utilizados no diagnóstico da alergia alimentar mediada ou não por IgE. FONTES DE DADOS: Artigos publicados em base de dados PubMed e Embase (língua inglesa e portuguesa) nos últimos dez anos. As palavras-chave utilizadas como fonte de busca foram \u0026quot;alergia alimentar\u0026quot;, \u0026quot;diagnóstico\u0026quot; e \u0026quot;laboratório\u0026quot;, isolados e/ou associados. SÍNTESE DOS DADOS: A abordagem diagnóstica das reações alérgicas a alimentos inclui história clínica completa, estudos laboratoriais, dietas de eliminação e desencadeamentos cegos com alimentos. Recentemente, a medida quantitativa de anticorpos IgE específicos a alimentos tem mostrado ser mais preditiva de alergia alimentar sintomática mediada por IgE. Níveis séricos de IgE específica a alimento que excedam os valores diagnósticos indicam que o paciente tem chance maior que 95% de apresentar uma reação alérgica se ingerir o alimento em questão. Estes \u0026quot;valores de decisão\u0026quot; ...","downloadable_attachments":[{"id":119813388,"asset_id":125843056,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":273609356,"first_name":"nelson","last_name":"rosario","domain_name":"independent","page_name":"nelsonrosario26","display_name":"nelson rosario","profile_url":"https://independent.academia.edu/nelsonrosario26?f_ri=168977","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false},{"id":47258,"name":"Food Allergy","url":"https://www.academia.edu/Documents/in/Food_Allergy?f_ri=168977","nofollow":false},{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=168977","nofollow":false},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=168977","nofollow":false},{"id":176180,"name":"Immunoglobulin E","url":"https://www.academia.edu/Documents/in/Immunoglobulin_E?f_ri=168977"},{"id":544999,"name":"Challenge","url":"https://www.academia.edu/Documents/in/Challenge?f_ri=168977"},{"id":2455582,"name":"Revista Paulista de Pediatria","url":"https://www.academia.edu/Documents/in/Revista_Paulista_de_Pediatria?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125832284" data-work_id="125832284" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125832284/A_year_long_fortnightly_observational_survey_in_three_European_countries_of_patients_with_respiratory_allergies_induced_by_house_dust_mites_Methodology_demographics_and_clinical_characteristics">A year-long, fortnightly, observational survey in three European countries of patients with respiratory allergies induced by house dust mites: Methodology, demographics and clinical characteristics</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">House dust mite (HDM) allergens constitute the leading trigger for the symptoms of persistent respiratory allergies (such as allergic rhinitis and asthma). However, the fluctuating, pernicious nature of the symptoms has given rise to a... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_125832284" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">House dust mite (HDM) allergens constitute the leading trigger for the symptoms of persistent respiratory allergies (such as allergic rhinitis and asthma). However, the fluctuating, pernicious nature of the symptoms has given rise to a perception that HDM-induced respiratory allergy is not a &quot;real&quot; disease. In order to assess the self-reported disease profile and behaviour of adult patients with a self-reported history of severe, poorly controlled, physician-diagnosed HDM respiratory allergy, we performed an observational, international, multicentre survey in three European countries (France, Italy and Spain). Participants were included in the survey if they passed a short Internet-based screening questionnaire. Following completion of a detailed post-inclusion questionnaire, 28 fortnightly telephone interviews were used to gather extensive data on the participants&#39; symptom prevalence and intensity, medical consultations, disease burden, quality of life, and medication...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125832284" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="93d2830a57bbdbc96b4f8d7f09c7f77e" rel="nofollow" data-download="{"attachment_id":119803843,"asset_id":125832284,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119803843/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38016153" href="https://independent.academia.edu/OlivieroRossi">Oliviero Rossi</a><script data-card-contents-for-user="38016153" type="text/json">{"id":38016153,"first_name":"Oliviero","last_name":"Rossi","domain_name":"independent","page_name":"OlivieroRossi","display_name":"Oliviero Rossi","profile_url":"https://independent.academia.edu/OlivieroRossi?f_ri=168977","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_125832284 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125832284"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125832284, container: ".js-paper-rank-work_125832284", }); 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$(".js-view-count[data-work-id=125832284]").text(description); $(".js-view-count-work_125832284").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_125832284").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="125832284"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="631" href="https://www.academia.edu/Documents/in/Pediatrics">Pediatrics</a>, <script data-card-contents-for-ri="631" type="text/json">{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7470" href="https://www.academia.edu/Documents/in/Quality_of_life">Quality of life</a>, <script data-card-contents-for-ri="7470" type="text/json">{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="9968" href="https://www.academia.edu/Documents/in/Asthma">Asthma</a>, <script data-card-contents-for-ri="9968" type="text/json">{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a><script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=125832284]'), work: {"id":125832284,"title":"A year-long, fortnightly, observational survey in three European countries of patients with respiratory allergies induced by house dust mites: Methodology, demographics and clinical characteristics","created_at":"2024-11-25T06:09:29.133-08:00","url":"https://www.academia.edu/125832284/A_year_long_fortnightly_observational_survey_in_three_European_countries_of_patients_with_respiratory_allergies_induced_by_house_dust_mites_Methodology_demographics_and_clinical_characteristics?f_ri=168977","dom_id":"work_125832284","summary":"House dust mite (HDM) allergens constitute the leading trigger for the symptoms of persistent respiratory allergies (such as allergic rhinitis and asthma). However, the fluctuating, pernicious nature of the symptoms has given rise to a perception that HDM-induced respiratory allergy is not a \u0026quot;real\u0026quot; disease. In order to assess the self-reported disease profile and behaviour of adult patients with a self-reported history of severe, poorly controlled, physician-diagnosed HDM respiratory allergy, we performed an observational, international, multicentre survey in three European countries (France, Italy and Spain). Participants were included in the survey if they passed a short Internet-based screening questionnaire. Following completion of a detailed post-inclusion questionnaire, 28 fortnightly telephone interviews were used to gather extensive data on the participants\u0026#39; symptom prevalence and intensity, medical consultations, disease burden, quality of life, and medication...","downloadable_attachments":[{"id":119803843,"asset_id":125832284,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38016153,"first_name":"Oliviero","last_name":"Rossi","domain_name":"independent","page_name":"OlivieroRossi","display_name":"Oliviero Rossi","profile_url":"https://independent.academia.edu/OlivieroRossi?f_ri=168977","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":631,"name":"Pediatrics","url":"https://www.academia.edu/Documents/in/Pediatrics?f_ri=168977","nofollow":false},{"id":7470,"name":"Quality of life","url":"https://www.academia.edu/Documents/in/Quality_of_life?f_ri=168977","nofollow":false},{"id":9968,"name":"Asthma","url":"https://www.academia.edu/Documents/in/Asthma?f_ri=168977","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=168977","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977"},{"id":27336,"name":"France","url":"https://www.academia.edu/Documents/in/France?f_ri=168977"},{"id":45213,"name":"Italy","url":"https://www.academia.edu/Documents/in/Italy?f_ri=168977"},{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=168977"},{"id":87529,"name":"Allergic rhinitis","url":"https://www.academia.edu/Documents/in/Allergic_rhinitis?f_ri=168977"},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=168977"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=168977"},{"id":649451,"name":"Seasons","url":"https://www.academia.edu/Documents/in/Seasons?f_ri=168977"},{"id":910024,"name":"Observational Study","url":"https://www.academia.edu/Documents/in/Observational_Study?f_ri=168977"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125829109" data-work_id="125829109" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125829109/Association_of_Roadway_Proximity_with_Indoor_Air_Pollution_in_a_Peri_Urban_Community_in_Lima_Peru">Association of Roadway Proximity with Indoor Air Pollution in a Peri-Urban Community in Lima, Peru</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125829109" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="213f0d250e32f658cf511356b66539a3" rel="nofollow" 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description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_125829109").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="125829109"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="402" href="https://www.academia.edu/Documents/in/Environmental_Science">Environmental Science</a>, <script data-card-contents-for-ri="402" type="text/json">{"id":402,"name":"Environmental Science","url":"https://www.academia.edu/Documents/in/Environmental_Science?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4592" href="https://www.academia.edu/Documents/in/Indoor_Air_Quality">Indoor Air Quality</a>, <script data-card-contents-for-ri="4592" type="text/json">{"id":4592,"name":"Indoor Air Quality","url":"https://www.academia.edu/Documents/in/Indoor_Air_Quality?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7403" href="https://www.academia.edu/Documents/in/Environmental_Health">Environmental Health</a>, <script data-card-contents-for-ri="7403" type="text/json">{"id":7403,"name":"Environmental Health","url":"https://www.academia.edu/Documents/in/Environmental_Health?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="11801" href="https://www.academia.edu/Documents/in/Environmental_Monitoring">Environmental Monitoring</a><script data-card-contents-for-ri="11801" type="text/json">{"id":11801,"name":"Environmental Monitoring","url":"https://www.academia.edu/Documents/in/Environmental_Monitoring?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=125829109]'), work: {"id":125829109,"title":"Association of Roadway Proximity with Indoor Air Pollution in a Peri-Urban Community in Lima, Peru","created_at":"2024-11-25T04:14:29.049-08:00","url":"https://www.academia.edu/125829109/Association_of_Roadway_Proximity_with_Indoor_Air_Pollution_in_a_Peri_Urban_Community_in_Lima_Peru?f_ri=168977","dom_id":"work_125829109","summary":null,"downloadable_attachments":[{"id":119801170,"asset_id":125829109,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":134988541,"first_name":"Karina","last_name":"Romero","domain_name":"independent","page_name":"KarinaRomero105","display_name":"Karina Romero","profile_url":"https://independent.academia.edu/KarinaRomero105?f_ri=168977","photo":"https://0.academia-photos.com/134988541/66891833/55250804/s65_karina.romero.jpeg"}],"research_interests":[{"id":402,"name":"Environmental 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E","url":"https://www.academia.edu/Documents/in/Immunoglobulin_E?f_ri=168977"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=168977"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=168977"},{"id":591601,"name":"Atopic Dermatitis","url":"https://www.academia.edu/Documents/in/Atopic_Dermatitis?f_ri=168977"},{"id":1470936,"name":"Age Groups","url":"https://www.academia.edu/Documents/in/Age_Groups?f_ri=168977"},{"id":2500734,"name":"Elderly patient","url":"https://www.academia.edu/Documents/in/Elderly_patient?f_ri=168977"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125750860" data-work_id="125750860" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125750860/Fuzzy_logic_for_personalized_healthcare_and_diagnostics_FuzzyApp_a_fuzzy_logic_based_allergen_protein_predictor">Fuzzy logic for personalized healthcare and diagnostics: FuzzyApp--a fuzzy logic based allergen-protein predictor</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The path to personalized medicine demands the use of new and customized biopharmaceutical products containing modified proteins. Hence, assessment of these products for allergenicity becomes mandatory before they are introduced as... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_125750860" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The path to personalized medicine demands the use of new and customized biopharmaceutical products containing modified proteins. Hence, assessment of these products for allergenicity becomes mandatory before they are introduced as therapeutics. Despite the availability of different tools to predict the allergenicity of proteins, it remains challenging to predict the allergens and nonallergens, when they share significant sequence similarity with known nonallergens and allergens, respectively. Hence, we propose &quot;FuzzyApp,&quot; a novel fuzzy rule based system to evaluate the quality of the query protein to be an allergen. It measures the allergenicity of the protein based on the fuzzy IF-THEN rules derived from five different modules. On various datasets, FuzzyApp outperformed other existing methods and retained balance between sensitivity and specificity, with positive Mathew&#39;s correlation coefficient. The high specificity of allergen-like putative nonallergens (APN) reveal...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125750860" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5ad9078d5350293ac633467269535096" rel="nofollow" data-download="{"attachment_id":119737174,"asset_id":125750860,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119737174/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="327076789" href="https://independent.academia.edu/vijayakumarSaravanan">Saravanan vijayakumar</a><script data-card-contents-for-user="327076789" type="text/json">{"id":327076789,"first_name":"Saravanan","last_name":"vijayakumar","domain_name":"independent","page_name":"vijayakumarSaravanan","display_name":"Saravanan vijayakumar","profile_url":"https://independent.academia.edu/vijayakumarSaravanan?f_ri=168977","photo":"https://0.academia-photos.com/327076789/168473751/158436939/s65_saravanan.vijayakumar.jpeg"}</script></span></span></li><li class="js-paper-rank-work_125750860 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125750860"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125750860, container: ".js-paper-rank-work_125750860", }); 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Hence, assessment of these products for allergenicity becomes mandatory before they are introduced as therapeutics. Despite the availability of different tools to predict the allergenicity of proteins, it remains challenging to predict the allergens and nonallergens, when they share significant sequence similarity with known nonallergens and allergens, respectively. Hence, we propose \u0026quot;FuzzyApp,\u0026quot; a novel fuzzy rule based system to evaluate the quality of the query protein to be an allergen. It measures the allergenicity of the protein based on the fuzzy IF-THEN rules derived from five different modules. On various datasets, FuzzyApp outperformed other existing methods and retained balance between sensitivity and specificity, with positive Mathew\u0026#39;s correlation coefficient. The high specificity of allergen-like putative nonallergens (APN) reveal...","downloadable_attachments":[{"id":119737174,"asset_id":125750860,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":327076789,"first_name":"Saravanan","last_name":"vijayakumar","domain_name":"independent","page_name":"vijayakumarSaravanan","display_name":"Saravanan vijayakumar","profile_url":"https://independent.academia.edu/vijayakumarSaravanan?f_ri=168977","photo":"https://0.academia-photos.com/327076789/168473751/158436939/s65_saravanan.vijayakumar.jpeg"}],"research_interests":[{"id":422,"name":"Computer Science","url":"https://www.academia.edu/Documents/in/Computer_Science?f_ri=168977","nofollow":false},{"id":2009,"name":"Data Mining","url":"https://www.academia.edu/Documents/in/Data_Mining?f_ri=168977","nofollow":false},{"id":4165,"name":"Fuzzy Logic","url":"https://www.academia.edu/Documents/in/Fuzzy_Logic?f_ri=168977","nofollow":false},{"id":13897,"name":"Personalized Medicine","url":"https://www.academia.edu/Documents/in/Personalized_Medicine?f_ri=168977","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=168977"},{"id":53293,"name":"Software","url":"https://www.academia.edu/Documents/in/Software?f_ri=168977"},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=168977"},{"id":202413,"name":"Arabidopsis","url":"https://www.academia.edu/Documents/in/Arabidopsis?f_ri=168977"},{"id":343667,"name":"Theoretical Models","url":"https://www.academia.edu/Documents/in/Theoretical_Models?f_ri=168977"},{"id":891449,"name":"Omics","url":"https://www.academia.edu/Documents/in/Omics?f_ri=168977"},{"id":1035050,"name":"Proteome","url":"https://www.academia.edu/Documents/in/Proteome?f_ri=168977"},{"id":1173343,"name":"Precision Medicine","url":"https://www.academia.edu/Documents/in/Precision_Medicine?f_ri=168977"},{"id":1191356,"name":"Internet","url":"https://www.academia.edu/Documents/in/Internet?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125730269" data-work_id="125730269" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125730269/Reducing_wheat_allergic_response_by_polyphenol_allergen_interactions">Reducing wheat allergic response by polyphenol-allergen interactions</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125730269" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f857ded5bee01a25337c69e996f0c7ac" rel="nofollow" data-download="{"attachment_id":119720176,"asset_id":125730269,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119720176/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39043039" href="https://inra.academia.edu/mariebodinier">marie bodinier</a><script data-card-contents-for-user="39043039" type="text/json">{"id":39043039,"first_name":"marie","last_name":"bodinier","domain_name":"inra","page_name":"mariebodinier","display_name":"marie bodinier","profile_url":"https://inra.academia.edu/mariebodinier?f_ri=168977","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_125730269 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125730269"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125730269, container: ".js-paper-rank-work_125730269", }); 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$(".js-view-count[data-work-id=125730269]").text(description); $(".js-view-count-work_125730269").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_125730269").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="125730269"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="832148" href="https://www.academia.edu/Documents/in/Polyphenol">Polyphenol</a>, <script data-card-contents-for-ri="832148" type="text/json">{"id":832148,"name":"Polyphenol","url":"https://www.academia.edu/Documents/in/Polyphenol?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2200981" href="https://www.academia.edu/Documents/in/Allergen">Allergen</a><script data-card-contents-for-ri="2200981" type="text/json">{"id":2200981,"name":"Allergen","url":"https://www.academia.edu/Documents/in/Allergen?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=125730269]'), work: {"id":125730269,"title":"Reducing wheat allergic response by polyphenol-allergen interactions","created_at":"2024-11-21T00:10:56.044-08:00","url":"https://www.academia.edu/125730269/Reducing_wheat_allergic_response_by_polyphenol_allergen_interactions?f_ri=168977","dom_id":"work_125730269","summary":null,"downloadable_attachments":[{"id":119720176,"asset_id":125730269,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39043039,"first_name":"marie","last_name":"bodinier","domain_name":"inra","page_name":"mariebodinier","display_name":"marie bodinier","profile_url":"https://inra.academia.edu/mariebodinier?f_ri=168977","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":832148,"name":"Polyphenol","url":"https://www.academia.edu/Documents/in/Polyphenol?f_ri=168977","nofollow":false},{"id":2200981,"name":"Allergen","url":"https://www.academia.edu/Documents/in/Allergen?f_ri=168977","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125730247" data-work_id="125730247" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125730247/Identification_of_IgE_binding_epitopes_on_gliadins_for_patients_with_food_allergy_to_wheat">Identification of IgE‐binding epitopes on gliadins for patients with food allergy to wheat</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Food allergy to wheat induces different symptoms as atopic eczema/dermatitis syndrome (AEDS), urticaria and more severe reactions as wheat‐dependent exercise‐induced anaphylaxis (WDEIA). Different gliadin classes are involved... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_125730247" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Food allergy to wheat induces different symptoms as atopic eczema/dermatitis syndrome (AEDS), urticaria and more severe reactions as wheat‐dependent exercise‐induced anaphylaxis (WDEIA). Different gliadin classes are involved in this allergy but IgE‐binding epitopes are known only on ω5‐gliadins and for WDEIA cases.Objectives: The aim of the study was to identify IgE‐binding epitopes on several gliadin classes and for several patients with different symptoms and ages.Methods: Eleven sera were analysed by pepscan with overlapping synthetic peptides.Results: Sera from five patients with anaphylaxis, urticaria or WDEIA, displayed strong IgE‐binding to sequential epitopes of the repetitive domains of αβ, γ, ω2 or ω5‐gliadins with two immunodominant epitopes on ω5‐gliadin and a consensus motif of the type QQX1PX2QQ (X1 being L, F, S or I and X2 Q, E or G). One patient allergic to deamidated wheat proteins also had IgE to a repetitive peptide of γ and ω2‐gliadins of the ty...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125730247" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="94a31e69e691e6e832a05bf1856545e4" rel="nofollow" data-download="{"attachment_id":119720225,"asset_id":125730247,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119720225/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39043039" href="https://inra.academia.edu/mariebodinier">marie bodinier</a><script data-card-contents-for-user="39043039" type="text/json">{"id":39043039,"first_name":"marie","last_name":"bodinier","domain_name":"inra","page_name":"mariebodinier","display_name":"marie bodinier","profile_url":"https://inra.academia.edu/mariebodinier?f_ri=168977","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_125730247 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125730247"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125730247, container: ".js-paper-rank-work_125730247", }); 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$(".js-view-count[data-work-id=125730247]").text(description); $(".js-view-count-work_125730247").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_125730247").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="125730247"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47258" href="https://www.academia.edu/Documents/in/Food_Allergy">Food Allergy</a>, <script data-card-contents-for-ri="47258" type="text/json">{"id":47258,"name":"Food Allergy","url":"https://www.academia.edu/Documents/in/Food_Allergy?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62896" href="https://www.academia.edu/Documents/in/Allergy">Allergy</a><script data-card-contents-for-ri="62896" type="text/json">{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=125730247]'), work: {"id":125730247,"title":"Identification of IgE‐binding epitopes on gliadins for patients with food allergy to wheat","created_at":"2024-11-21T00:10:36.610-08:00","url":"https://www.academia.edu/125730247/Identification_of_IgE_binding_epitopes_on_gliadins_for_patients_with_food_allergy_to_wheat?f_ri=168977","dom_id":"work_125730247","summary":"Background: Food allergy to wheat induces different symptoms as atopic eczema/dermatitis syndrome (AEDS), urticaria and more severe reactions as wheat‐dependent exercise‐induced anaphylaxis (WDEIA). Different gliadin classes are involved in this allergy but IgE‐binding epitopes are known only on ω5‐gliadins and for WDEIA cases.Objectives: The aim of the study was to identify IgE‐binding epitopes on several gliadin classes and for several patients with different symptoms and ages.Methods: Eleven sera were analysed by pepscan with overlapping synthetic peptides.Results: Sera from five patients with anaphylaxis, urticaria or WDEIA, displayed strong IgE‐binding to sequential epitopes of the repetitive domains of αβ, γ, ω2 or ω5‐gliadins with two immunodominant epitopes on ω5‐gliadin and a consensus motif of the type QQX1PX2QQ (X1 being L, F, S or I and X2 Q, E or G). One patient allergic to deamidated wheat proteins also had IgE to a repetitive peptide of γ and ω2‐gliadins of the ty...","downloadable_attachments":[{"id":119720225,"asset_id":125730247,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39043039,"first_name":"marie","last_name":"bodinier","domain_name":"inra","page_name":"mariebodinier","display_name":"marie bodinier","profile_url":"https://inra.academia.edu/mariebodinier?f_ri=168977","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false},{"id":47258,"name":"Food Allergy","url":"https://www.academia.edu/Documents/in/Food_Allergy?f_ri=168977","nofollow":false},{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=168977","nofollow":false},{"id":67484,"name":"Sequence alignment","url":"https://www.academia.edu/Documents/in/Sequence_alignment?f_ri=168977"},{"id":71673,"name":"Gliadin","url":"https://www.academia.edu/Documents/in/Gliadin?f_ri=168977"},{"id":72018,"name":"Anaphylaxis","url":"https://www.academia.edu/Documents/in/Anaphylaxis?f_ri=168977"},{"id":135185,"name":"Exercise","url":"https://www.academia.edu/Documents/in/Exercise?f_ri=168977"},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=168977"},{"id":176180,"name":"Immunoglobulin E","url":"https://www.academia.edu/Documents/in/Immunoglobulin_E?f_ri=168977"},{"id":591601,"name":"Atopic Dermatitis","url":"https://www.academia.edu/Documents/in/Atopic_Dermatitis?f_ri=168977"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=168977"},{"id":991443,"name":"Triticum","url":"https://www.academia.edu/Documents/in/Triticum?f_ri=168977"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data?f_ri=168977"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=168977"},{"id":3398462,"name":"epitope","url":"https://www.academia.edu/Documents/in/epitope?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125719616" data-work_id="125719616" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125719616/Old_Apple_Malus_domestica_L_Borkh_Varieties_with_Hypoallergenic_Properties_An_Integrated_Approach_for_Studying_Apple_Allergenicity">Old Apple (Malus domestica L. Borkh) Varieties with Hypoallergenic Properties: An Integrated Approach for Studying Apple Allergenicity</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125719616" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2bf1c349e1e7750c6c49ad083b3857bd" rel="nofollow" data-download="{"attachment_id":119711413,"asset_id":125719616,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119711413/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="325533753" href="https://independent.academia.edu/AndreaAntico1">Andrea Antico</a><script data-card-contents-for-user="325533753" type="text/json">{"id":325533753,"first_name":"Andrea","last_name":"Antico","domain_name":"independent","page_name":"AndreaAntico1","display_name":"Andrea Antico","profile_url":"https://independent.academia.edu/AndreaAntico1?f_ri=168977","photo":"https://0.academia-photos.com/325533753/167177715/157123612/s65_andrea.antico.png"}</script></span></span></li><li class="js-paper-rank-work_125719616 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125719616"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125719616, container: ".js-paper-rank-work_125719616", }); 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$(".js-view-count[data-work-id=125719616]").text(description); $(".js-view-count-work_125719616").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_125719616").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="125719616"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">18</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="48" href="https://www.academia.edu/Documents/in/Engineering">Engineering</a>, <script data-card-contents-for-ri="48" type="text/json">{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="156" href="https://www.academia.edu/Documents/in/Genetics">Genetics</a>, <script data-card-contents-for-ri="156" type="text/json">{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="5541" href="https://www.academia.edu/Documents/in/Plant_Biology">Plant Biology</a><script data-card-contents-for-ri="5541" type="text/json">{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=125719616]'), work: {"id":125719616,"title":"Old Apple (Malus domestica L. Borkh) Varieties with Hypoallergenic Properties: An Integrated Approach for Studying Apple Allergenicity","created_at":"2024-11-20T11:28:14.652-08:00","url":"https://www.academia.edu/125719616/Old_Apple_Malus_domestica_L_Borkh_Varieties_with_Hypoallergenic_Properties_An_Integrated_Approach_for_Studying_Apple_Allergenicity?f_ri=168977","dom_id":"work_125719616","summary":null,"downloadable_attachments":[{"id":119711413,"asset_id":125719616,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":325533753,"first_name":"Andrea","last_name":"Antico","domain_name":"independent","page_name":"AndreaAntico1","display_name":"Andrea Antico","profile_url":"https://independent.academia.edu/AndreaAntico1?f_ri=168977","photo":"https://0.academia-photos.com/325533753/167177715/157123612/s65_andrea.antico.png"}],"research_interests":[{"id":48,"name":"Engineering","url":"https://www.academia.edu/Documents/in/Engineering?f_ri=168977","nofollow":false},{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics?f_ri=168977","nofollow":false},{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false},{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology?f_ri=168977","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=168977"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977"},{"id":62896,"name":"Allergy","url":"https://www.academia.edu/Documents/in/Allergy?f_ri=168977"},{"id":160814,"name":"Fruit","url":"https://www.academia.edu/Documents/in/Fruit?f_ri=168977"},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=168977"},{"id":260118,"name":"CHEMICAL SCIENCES","url":"https://www.academia.edu/Documents/in/CHEMICAL_SCIENCES?f_ri=168977"},{"id":285086,"name":"Integrated Approach","url":"https://www.academia.edu/Documents/in/Integrated_Approach?f_ri=168977"},{"id":363381,"name":"Malus","url":"https://www.academia.edu/Documents/in/Malus?f_ri=168977"},{"id":372410,"name":"Genotype","url":"https://www.academia.edu/Documents/in/Genotype?f_ri=168977"},{"id":416370,"name":"Gene Expression Studies","url":"https://www.academia.edu/Documents/in/Gene_Expression_Studies?f_ri=168977"},{"id":418866,"name":"Food Allergen","url":"https://www.academia.edu/Documents/in/Food_Allergen?f_ri=168977"},{"id":596974,"name":"Agricultural and Food Chemistry","url":"https://www.academia.edu/Documents/in/Agricultural_and_Food_Chemistry?f_ri=168977"},{"id":3560415,"name":"Malus domestica","url":"https://www.academia.edu/Documents/in/Malus_domestica?f_ri=168977"},{"id":4076953,"name":"food hypersensitivity","url":"https://www.academia.edu/Documents/in/food_hypersensitivity?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125719611" data-work_id="125719611" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125719611/Pomegranate_Punica_granatum_L_Expresses_Several_nsLTP_Isoforms_Characterized_by_Different_Immunoglobulin_E_Binding_Properties">Pomegranate (Punica granatum L.) Expresses Several nsLTP Isoforms Characterized by Different Immunoglobulin E-Binding Properties</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: Pomegranate allergy is associated with sensitization to non-specific lipid transfer proteins (nsLTPs). Our aim was to identify and characterize the non-specific nsLTPs expressed in pomegranate at the molecular level and to... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_125719611" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: Pomegranate allergy is associated with sensitization to non-specific lipid transfer proteins (nsLTPs). Our aim was to identify and characterize the non-specific nsLTPs expressed in pomegranate at the molecular level and to study their allergenic properties in terms of immunoglobulin E (IgE)-binding and cross-reactivity with peach nsLTP (Pru p 3). Methods: A non-equilibrium two-dimensional (2-D) electrophoretic approach based on acid-urea PAGE and sodium dodecyl sulfate PAGE was set up to separate pomegranate nsLTPs. Their immunoreactivity was tested by immunoblotting carried out with anti-Pru p 3 polyclonal antibodies and sera from pomegranate-allergic patients. For final identification, pomegranate nsLTPs were purified by chromatography and subjected to trypsin digestion and mass spectrometry (MS) analysis. For this purpose, the sequences obtained by cDNA cloning of three pomegranate nsLTPs were integrated in the database that was subsequently searched for MS data inter...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125719611" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="aa985f5ad720bd56f4117552bd930bc9" rel="nofollow" data-download="{"attachment_id":119711400,"asset_id":125719611,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119711400/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="325533753" href="https://independent.academia.edu/AndreaAntico1">Andrea Antico</a><script data-card-contents-for-user="325533753" type="text/json">{"id":325533753,"first_name":"Andrea","last_name":"Antico","domain_name":"independent","page_name":"AndreaAntico1","display_name":"Andrea Antico","profile_url":"https://independent.academia.edu/AndreaAntico1?f_ri=168977","photo":"https://0.academia-photos.com/325533753/167177715/157123612/s65_andrea.antico.png"}</script></span></span></li><li class="js-paper-rank-work_125719611 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125719611"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125719611, container: ".js-paper-rank-work_125719611", }); 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$(".js-view-count[data-work-id=125719611]").text(description); $(".js-view-count-work_125719611").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_125719611").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="125719611"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="523" href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a>, <script data-card-contents-for-ri="523" type="text/json">{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="1290" href="https://www.academia.edu/Documents/in/Immunology">Immunology</a>, <script data-card-contents-for-ri="1290" type="text/json">{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2513" href="https://www.academia.edu/Documents/in/Molecular_Biology">Molecular Biology</a>, <script data-card-contents-for-ri="2513" type="text/json">{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a><script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=125719611]'), work: {"id":125719611,"title":"Pomegranate (Punica granatum L.) Expresses Several nsLTP Isoforms Characterized by Different Immunoglobulin E-Binding Properties","created_at":"2024-11-20T11:28:12.815-08:00","url":"https://www.academia.edu/125719611/Pomegranate_Punica_granatum_L_Expresses_Several_nsLTP_Isoforms_Characterized_by_Different_Immunoglobulin_E_Binding_Properties?f_ri=168977","dom_id":"work_125719611","summary":"Background: Pomegranate allergy is associated with sensitization to non-specific lipid transfer proteins (nsLTPs). Our aim was to identify and characterize the non-specific nsLTPs expressed in pomegranate at the molecular level and to study their allergenic properties in terms of immunoglobulin E (IgE)-binding and cross-reactivity with peach nsLTP (Pru p 3). Methods: A non-equilibrium two-dimensional (2-D) electrophoretic approach based on acid-urea PAGE and sodium dodecyl sulfate PAGE was set up to separate pomegranate nsLTPs. Their immunoreactivity was tested by immunoblotting carried out with anti-Pru p 3 polyclonal antibodies and sera from pomegranate-allergic patients. For final identification, pomegranate nsLTPs were purified by chromatography and subjected to trypsin digestion and mass spectrometry (MS) analysis. For this purpose, the sequences obtained by cDNA cloning of three pomegranate nsLTPs were integrated in the database that was subsequently searched for MS data inter...","downloadable_attachments":[{"id":119711400,"asset_id":125719611,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":325533753,"first_name":"Andrea","last_name":"Antico","domain_name":"independent","page_name":"AndreaAntico1","display_name":"Andrea Antico","profile_url":"https://independent.academia.edu/AndreaAntico1?f_ri=168977","photo":"https://0.academia-photos.com/325533753/167177715/157123612/s65_andrea.antico.png"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry?f_ri=168977","nofollow":false},{"id":1290,"name":"Immunology","url":"https://www.academia.edu/Documents/in/Immunology?f_ri=168977","nofollow":false},{"id":2513,"name":"Molecular Biology","url":"https://www.academia.edu/Documents/in/Molecular_Biology?f_ri=168977","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false},{"id":67484,"name":"Sequence alignment","url":"https://www.academia.edu/Documents/in/Sequence_alignment?f_ri=168977"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=168977"},{"id":168977,"name":"Allergens","url":"https://www.academia.edu/Documents/in/Allergens?f_ri=168977"},{"id":176180,"name":"Immunoglobulin E","url":"https://www.academia.edu/Documents/in/Immunoglobulin_E?f_ri=168977"},{"id":470726,"name":"Polyclonal Antibodies","url":"https://www.academia.edu/Documents/in/Polyclonal_Antibodies?f_ri=168977"},{"id":486795,"name":"Prunus","url":"https://www.academia.edu/Documents/in/Prunus?f_ri=168977"},{"id":743709,"name":"Protein isoforms","url":"https://www.academia.edu/Documents/in/Protein_isoforms?f_ri=168977"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence?f_ri=168977"},{"id":1181939,"name":"PLANT PROTEINS","url":"https://www.academia.edu/Documents/in/PLANT_PROTEINS?f_ri=168977"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data?f_ri=168977"},{"id":2867165,"name":"Punicaceae","url":"https://www.academia.edu/Documents/in/Punicaceae?f_ri=168977"},{"id":4076953,"name":"food hypersensitivity","url":"https://www.academia.edu/Documents/in/food_hypersensitivity?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125707553" data-work_id="125707553" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125707553/Peak_Nasal_Inspiratory_Flow_Reference_Values_for_Thais">Peak Nasal Inspiratory Flow: Reference Values for Thais</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective: Nasal obstruction can be measured objectively by rhinomanometry and acoustic rhinometry, both complex techniques. Peak nasal inspiratory flow (PNIF) is also a tool for evaluating nasal obstruction. This study aimed to establish... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_125707553" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective: Nasal obstruction can be measured objectively by rhinomanometry and acoustic rhinometry, both complex techniques. Peak nasal inspiratory flow (PNIF) is also a tool for evaluating nasal obstruction. This study aimed to establish normal PNIF ranges for an Asian population accounting for sex, age, weight, and height. Methods: Using a portable Youlten peak flowmeter, PNIF was measured in 180 healthy Thais (ages 15-70 years). Normal ranges for male and female subjects, adjusted for weight and height, were determined using multiple regression analysis. Results: Body mass index values (mean ± S.D.) of the 82 male and 98 female subjects were 24.9 ± 4.5 and 21.7 ± 4.3 kg/m2, respectively. PNIF was significantly higher in males than in females (139 ± 37.6 vs. 97.1 ± 27.1 l/ min, p&lt;0.001). After adjusting for weight and height, PNIF reference ranges (lower and upper limits with 95% confidence intervals, respectively) were 126.8 (124.5 to 129.1) and 151.2 (148.9 to 153.5) l/min fo...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125707553" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="914d95777ce8ccfc1da322a838db547b" rel="nofollow" data-download="{"attachment_id":119701908,"asset_id":125707553,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119701908/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="38970828" href="https://independent.academia.edu/PongsakornTantilipikorn">Pongsakorn Tantilipikorn</a><script data-card-contents-for-user="38970828" type="text/json">{"id":38970828,"first_name":"Pongsakorn","last_name":"Tantilipikorn","domain_name":"independent","page_name":"PongsakornTantilipikorn","display_name":"Pongsakorn Tantilipikorn","profile_url":"https://independent.academia.edu/PongsakornTantilipikorn?f_ri=168977","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_125707553 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125707553"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125707553, container: ".js-paper-rank-work_125707553", }); 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$(".js-view-count[data-work-id=125707553]").text(description); $(".js-view-count-work_125707553").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_125707553").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="125707553"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="973187" href="https://www.academia.edu/Documents/in/Thais">Thais</a><script data-card-contents-for-ri="973187" type="text/json">{"id":973187,"name":"Thais","url":"https://www.academia.edu/Documents/in/Thais?f_ri=168977","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=125707553]'), work: {"id":125707553,"title":"Peak Nasal Inspiratory Flow: Reference Values for Thais","created_at":"2024-11-20T02:12:08.547-08:00","url":"https://www.academia.edu/125707553/Peak_Nasal_Inspiratory_Flow_Reference_Values_for_Thais?f_ri=168977","dom_id":"work_125707553","summary":"Objective: Nasal obstruction can be measured objectively by rhinomanometry and acoustic rhinometry, both complex techniques. Peak nasal inspiratory flow (PNIF) is also a tool for evaluating nasal obstruction. This study aimed to establish normal PNIF ranges for an Asian population accounting for sex, age, weight, and height. Methods: Using a portable Youlten peak flowmeter, PNIF was measured in 180 healthy Thais (ages 15-70 years). Normal ranges for male and female subjects, adjusted for weight and height, were determined using multiple regression analysis. Results: Body mass index values (mean ± S.D.) of the 82 male and 98 female subjects were 24.9 ± 4.5 and 21.7 ± 4.3 kg/m2, respectively. PNIF was significantly higher in males than in females (139 ± 37.6 vs. 97.1 ± 27.1 l/ min, p\u0026lt;0.001). After adjusting for weight and height, PNIF reference ranges (lower and upper limits with 95% confidence intervals, respectively) were 126.8 (124.5 to 129.1) and 151.2 (148.9 to 153.5) l/min fo...","downloadable_attachments":[{"id":119701908,"asset_id":125707553,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":38970828,"first_name":"Pongsakorn","last_name":"Tantilipikorn","domain_name":"independent","page_name":"PongsakornTantilipikorn","display_name":"Pongsakorn Tantilipikorn","profile_url":"https://independent.academia.edu/PongsakornTantilipikorn?f_ri=168977","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=168977","nofollow":false},{"id":973187,"name":"Thais","url":"https://www.academia.edu/Documents/in/Thais?f_ri=168977","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125700583" data-work_id="125700583" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125700583/Sensitization_to_cereal_allergens_in_children_with_atopic_dermatitis">Sensitization to cereal allergens in children with atopic dermatitis</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125700583" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f18b8f164723a5096153bd56e1382390" rel="nofollow" data-download="{"attachment_id":119696387,"asset_id":125700583,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119696387/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35504693" href="https://umwb.academia.edu/MaciejKaczmarski">Maciej G Kaczmarski</a><script data-card-contents-for-user="35504693" type="text/json">{"id":35504693,"first_name":"Maciej","last_name":"Kaczmarski","domain_name":"umwb","page_name":"MaciejKaczmarski","display_name":"Maciej G Kaczmarski","profile_url":"https://umwb.academia.edu/MaciejKaczmarski?f_ri=168977","photo":"https://0.academia-photos.com/35504693/11534130/12863884/s65_maciej.kaczmarski.jpg"}</script></span></span></li><li class="js-paper-rank-work_125700583 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125700583"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125700583, container: ".js-paper-rank-work_125700583", }); 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The innate immune molecule surfactant protein D (SP-D) binds selectively to microorganisms, inducing aggregation and phagocytosis. In... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_125652871" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Helicobacter pylori establishes persistent infection of gastric mucosa with diverse clinical outcomes. The innate immune molecule surfactant protein D (SP-D) binds selectively to microorganisms, inducing aggregation and phagocytosis. In this study, we demonstrated the expression of SP-D in gastric mucosa by reverse transcription-PCR and immuohistochemical analysis. SP-D is present at the luminal surface and within the gastric pits, with maximal expression at the surface. Levels of expression are significantly increased in H. pylori -associated gastritis compared to those in the normal mucosa. Immunofluorescence microscopy was used to demonstrate binding and agglutination of H. pylori by SP-D in a lectin-specific manner. These activities resulted in a 50% reduction in the motility of H. pylori , as judged on the basis of curvilinear velocity measured by using a Hobson BacTracker. Lipopolysaccharides extracted from three H. pylori strains were shown to bind SP-D in a concentration-dep...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125652871" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c21c563c64fbd7b8bf33e54e614f35a6" rel="nofollow" data-download="{"attachment_id":119656879,"asset_id":125652871,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119656879/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="324478085" href="https://independent.academia.edu/MulugetaWorku27">Mulugeta Worku</a><script data-card-contents-for-user="324478085" type="text/json">{"id":324478085,"first_name":"Mulugeta","last_name":"Worku","domain_name":"independent","page_name":"MulugetaWorku27","display_name":"Mulugeta Worku","profile_url":"https://independent.academia.edu/MulugetaWorku27?f_ri=168977","photo":"https://0.academia-photos.com/324478085/166273608/156160236/s65_mulugeta.worku.jpeg"}</script></span></span></li><li class="js-paper-rank-work_125652871 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125652871"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125652871, container: ".js-paper-rank-work_125652871", }); 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The innate immune molecule surfactant protein D (SP-D) binds selectively to microorganisms, inducing aggregation and phagocytosis. In this study, we demonstrated the expression of SP-D in gastric mucosa by reverse transcription-PCR and immuohistochemical analysis. SP-D is present at the luminal surface and within the gastric pits, with maximal expression at the surface. Levels of expression are significantly increased in H. pylori -associated gastritis compared to those in the normal mucosa. Immunofluorescence microscopy was used to demonstrate binding and agglutination of H. pylori by SP-D in a lectin-specific manner. These activities resulted in a 50% reduction in the motility of H. pylori , as judged on the basis of curvilinear velocity measured by using a Hobson BacTracker. Lipopolysaccharides extracted from three H. pylori strains were shown to bind SP-D in a concentration-dep...","downloadable_attachments":[{"id":119656879,"asset_id":125652871,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":324478085,"first_name":"Mulugeta","last_name":"Worku","domain_name":"independent","page_name":"MulugetaWorku27","display_name":"Mulugeta Worku","profile_url":"https://independent.academia.edu/MulugetaWorku27?f_ri=168977","photo":"https://0.academia-photos.com/324478085/166273608/156160236/s65_mulugeta.worku.jpeg"}],"research_interests":[{"id":2702,"name":"Immune response","url":"https://www.academia.edu/Documents/in/Immune_response?f_ri=168977","nofollow":false},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=168977","nofollow":false},{"id":21460,"name":"Helicobacter pylori","url":"https://www.academia.edu/Documents/in/Helicobacter_pylori?f_ri=168977","nofollow":false},{"id":47884,"name":"Biological 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thrombocytopenia","url":"https://www.academia.edu/Documents/in/Immune_thrombocytopenia?f_ri=168977"},{"id":4055529,"name":"Corticosteroid","url":"https://www.academia.edu/Documents/in/Corticosteroid?f_ri=168977"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_125622370" data-work_id="125622370" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/125622370/Development_of_a_clinical_score_system_for_the_diagnosis_of_photoallergic_contact_dermatitis_using_a_consensus_process_item_selection_and_reliability">Development of a clinical score system for the diagnosis of photoallergic contact dermatitis using a consensus process: item selection and reliability</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Photoallergic contact dermatitis (PACD) is an uncommon condition, and there is a lack of validated criteria for its diagnosis. To identify a set of relevant criteria to be considered when suspecting a diagnosis of PACD and to assess the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_125622370" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Photoallergic contact dermatitis (PACD) is an uncommon condition, and there is a lack of validated criteria for its diagnosis. To identify a set of relevant criteria to be considered when suspecting a diagnosis of PACD and to assess the reproducibility of these criteria. This was a diagnostic item selection and reliability study performed between July 2012 and October 2012. A panel of seven recognized experts was invited to consecutive rounds of a Delphi survey and to a conclusive face-to-face meeting with the aim of obtaining an agreement on criteria for the diagnosis of PACD. The panel was also provided with a series of 16 reports of suspected PACDs to be classified according to a five-point likelihood scale. Identified criteria with the weights attributed by experts were used to develop a score system for the diagnosis of PACD. Consensus was measured by calculating the Intraclass Correlation Coefficient (ICC). The performance of the score system was evaluated in terms of overall ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/125622370" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="837703f7100b59eece6359ae4fa50bc2" rel="nofollow" data-download="{"attachment_id":119631223,"asset_id":125622370,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/119631223/download_file?st=MTczMzI1MjU2Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="319803268" href="https://independent.academia.edu/SilviaLecchi2">Silvia Lecchi</a><script data-card-contents-for-user="319803268" type="text/json">{"id":319803268,"first_name":"Silvia","last_name":"Lecchi","domain_name":"independent","page_name":"SilviaLecchi2","display_name":"Silvia Lecchi","profile_url":"https://independent.academia.edu/SilviaLecchi2?f_ri=168977","photo":"https://0.academia-photos.com/319803268/162227729/151979580/s65_silvia.lecchi.png"}</script></span></span></li><li class="js-paper-rank-work_125622370 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="125622370"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 125622370, container: ".js-paper-rank-work_125622370", }); 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