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}) })(jQuery); </script> </head> <body class="post-template-default single single-post postid-261 single-format-standard header-image full-width-content genesis-breadcrumbs-visible"><div class="site-container"><header class="site-header"><div class="wrap"><div class="title-area"><p class="site-title"><a href="https://www.thermofisher.com/" title="Thermo Fisher Scientific">Thermo Fisher Scientific</a></p><p class="site-description">Electron and cryo-electron microscopy stories and solutions about the advancement of cellular and structural biology</p></div><div class="widget-area header-widget-area"><section id="block-5" class="widget widget_block"><div class="widget-wrap"> <div class="wp-block-group"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"></div></div> </div></section> <section id="block-6" class="widget widget_block"><div class="widget-wrap"> <div class="wp-block-group"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"></div></div> </div></section> </div><div class="breadcrumb"><span class="breadcrumb-link-wrap"><a href="https://www.thermofisher.com/blog/?">Accelerating Science</a></span><span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/atomic-resolution/"><span class="breadcrumb-link-text-wrap">Life in Atomic Resolution</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/atomic-resolution/cryo-electron-microscopy-cryo-em/"><span class="breadcrumb-link-text-wrap">Cryo-Electron Microscopy (Cryo-EM)</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-current-title">The Transformation of Cryo-Electron Tomography</span></div></div></header><div class="site-inner"><div class="content-sidebar-wrap"><main class="content"><article class="post-261 post type-post status-publish format-standard has-post-thumbnail category-cryo-electron-microscopy-cryo-em category-cryo-electron-tomography tag-3d tag-cryo-electron-tomography tag-cryo-et tag-diamond-light-source tag-drug-discovery tag-genetic-mutation tag-rosalind-franklin-institute entry" aria-label="The Transformation of Cryo-Electron Tomography"><header class="entry-header"><h1 class="entry-title">The Transformation of Cryo-Electron Tomography</h1> <span class="post-info-author"> By <a href="https://www.thermofisher.com/blog/author/bernhardgoetze/" title="Posts by Bernhard Goetze" rel="author">Bernhard Goetze</a> </span> <span class="post-info-date"> 05.20.2019 </span> </header><div class="entry-content"><p>Last week, we joined the Rosalind Franklin Institute at Diamond Light Source to celebrate the groundbreaking of a new building that is part of an exciting and ambitious collaboration to transform our understanding of diseases and improve how new medicines are designed. Based on cryo-electron tomography (cryo-ET), the goal of the five-year project is to further develop this technique so scientists can see how a drug works at a cellular level or the molecular processes set in motion by a genetic mutation.</p> <p><img decoding="async" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/04/cryo-et2.jpg" /></p> <p style="text-align: center"><em>Members of Rosalind Franklin Institute’s board of directors gather at the groundbreaking ceremony. </em></p> <p>Cryo-ET uses electron beams to take multiple 2D images of a cryogenic sample, which are then combined to generate a 3D image of the inner workings of cells. While the technique is used today, it can only handle small samples, such as parts of cells, and requires in-house expertise.</p> <p>This undertaking is challenging. We’ll need to invent new technologies that can prepare and handle samples of human tissue that are the width of a hundredth of the thickness of a human hair. We’ll also have to design new software to speed the imaging process and collect more data faster. This will allow scientists to process much larger samples, increase workflow automation and standardize post-processing data. As we highlighted at the event, our longer term goal is to bring the technology closer to the clinic so it can be used in both research hospitals and laboratories.</p> <p><iframe title="Rosalind Franklin Institute and Thermo Fisher Scientific collaboration" width="760" height="428" src="https://www.youtube.com/embed/sjI_03ErZYM?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p> <p>Lead researcher and Director of the Rosalind Franklin Institute, Professor James Naismith, says it’s worth the effort:</p> <blockquote><p>“We’re currently able to identify genes and proteins that play a role in diseases but can only study these in detail in isolation, not as part of a whole cell or group of cells. This new technology would be the first to allow us to do that, so we can see the full effects of a drug and identify at a much earlier stage what will work and what will not.”</p></blockquote> <p><img decoding="async" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/04/cryo-et1.jpg" /></p> <p style="text-align: center"><em>Nick Chism (left), Chief Business Advisor at BEIS, stands with Thermo Fisher’s vice president and general manager, Electron Microscopy, Rob Krueger (right).</em></p> <p>For more information on the partnership and how it will revolutionize drug development, read the <a href="https://ter.li/5hb9qq">press release</a>.</p> <p><em>Bernhard Goetze is director, product marketing at Thermo Fisher Scientific. </em><a href="https://www.thermofisher.com/blog/microscopy/subscribe-to-accelerating-microscopy/">Subscribe to Accelerating Microscopy</a> to receive updates straight to your inbox.</p> <p>To learn more about cryo-electron tomography, <a href="https://ter.li/vpcd3g">fill out this form</a> to speak with an expert.</p>  <div class="jp-relatedposts"> <div class="related-post related-1"> <a href="https://www.thermofisher.com/blog/atomic-resolution/what-is-cryo-em-what-is-cryo-electron-microscopy/"><img width="310" height="274" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2024/10/cryoEM-blog-virus-pore4-1920x600_Header-310x274.jpg" class="attachment-grid size-grid wp-post-image" alt="cryoEM-blog-virus pore" decoding="async" /></a> <span class="grid-content"> <h4 class="entry-title"><a href="https://www.thermofisher.com/blog/atomic-resolution/what-is-cryo-em-what-is-cryo-electron-microscopy/">What is cryo-EM?</a></h4> <p>Cryo-EM: cryo electron microscopy Cryo-electron microscopy (... </p> <a href="https://www.thermofisher.com/blog/atomic-resolution/what-is-cryo-em-what-is-cryo-electron-microscopy/" class="read-more">Read More <i class="fa fa-icon 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