CINXE.COM

<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML+RDFa 1.0//EN" "http://www.w3.org/MarkUp/DTD/xhtml-rdfa-1.dtd"> <html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" version="XHTML+RDFa 1.0" dir="ltr" xmlns:content="http://purl.org/rss/1.0/modules/content/" xmlns:dc="http://purl.org/dc/terms/" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:og="http://ogp.me/ns#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:sioc="http://rdfs.org/sioc/ns#" xmlns:sioct="http://rdfs.org/sioc/types#" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#"> <head profile="http://www.w3.org/1999/xhtml/vocab"> <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /><script type="text/javascript">(window.NREUM||(NREUM={})).init={privacy:{cookies_enabled:true},ajax:{deny_list:["bam.nr-data.net"]},distributed_tracing:{enabled:true}};(window.NREUM||(NREUM={})).loader_config={agentID:"1103353965",accountID:"4430907",trustKey:"49206",xpid:"UAIEUV9TDxABVFNQBgMCXlYE",licenseKey:"NRJS-dd6144c4de227d09eb4",applicationID:"1022125825"};;/*! For license information please see nr-loader-spa-1.274.0.min.js.LICENSE.txt */ (()=>{var e,t,r={8122:(e,t,r)=>{"use strict";r.d(t,{a:()=>i});var n=r(944);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.R)(3);if(!t||"object"!=typeof t)return(0,n.R)(4);const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{if(null===e[a]){r[a]=null;continue}Array.isArray(e[a])&&Array.isArray(t[a])?r[a]=Array.from(new Set([...e[a],...t[a]])):"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){(0,n.R)(1,e)}return r}catch(e){(0,n.R)(2,e)}}},2555:(e,t,r)=>{"use strict";r.d(t,{Vp:()=>c,fn:()=>s,x1:()=>u});var n=r(384),i=r(8122);const o={beacon:n.NT.beacon,errorBeacon:n.NT.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0},a={};function s(e){try{const t=c(e);return!!t.licenseKey&&!!t.errorBeacon&&!!t.applicationID}catch(e){return!1}}function c(e){if(!e)throw new Error("All info objects require an agent identifier!");if(!a[e])throw new Error("Info for ".concat(e," was never set"));return a[e]}function u(e,t){if(!e)throw new Error("All info objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.info=a[e])}},9417:(e,t,r)=>{"use strict";r.d(t,{D0:()=>h,gD:()=>g,xN:()=>p});var n=r(993);const i=e=>{if(!e||"string"!=typeof e)return!1;try{document.createDocumentFragment().querySelector(e)}catch{return!1}return!0};var o=r(2614),a=r(944),s=r(384),c=r(8122);const u="[data-nr-mask]",d=()=>{const e={mask_selector:"*",block_selector:"[data-nr-block]",mask_input_options:{color:!1,date:!1,"datetime-local":!1,email:!1,month:!1,number:!1,range:!1,search:!1,tel:!1,text:!1,time:!1,url:!1,week:!1,textarea:!1,select:!1,password:!0}};return{ajax:{deny_list:void 0,block_internal:!0,enabled:!0,harvestTimeSeconds:10,autoStart:!0},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},feature_flags:[],generic_events:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},harvest:{tooManyRequestsDelay:60},jserrors:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},logging:{enabled:!0,harvestTimeSeconds:10,autoStart:!0,level:n.p_.INFO},metrics:{enabled:!0,autoStart:!0},obfuscate:void 0,page_action:{enabled:!0},page_view_event:{enabled:!0,autoStart:!0},page_view_timing:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},performance:{capture_marks:!1,capture_measures:!1},privacy:{cookies_enabled:!0},proxy:{assets:void 0,beacon:void 0},session:{expiresMs:o.wk,inactiveMs:o.BB},session_replay:{autoStart:!0,enabled:!1,harvestTimeSeconds:60,preload:!1,sampling_rate:10,error_sampling_rate:100,collect_fonts:!1,inline_images:!1,fix_stylesheets:!0,mask_all_inputs:!0,get mask_text_selector(){return e.mask_selector},set mask_text_selector(t){i(t)?e.mask_selector="".concat(t,",").concat(u):""===t||null===t?e.mask_selector=u:(0,a.R)(5,t)},get block_class(){return"nr-block"},get ignore_class(){return"nr-ignore"},get mask_text_class(){return"nr-mask"},get block_selector(){return e.block_selector},set block_selector(t){i(t)?e.block_selector+=",".concat(t):""!==t&&(0,a.R)(6,t)},get mask_input_options(){return e.mask_input_options},set mask_input_options(t){t&&"object"==typeof t?e.mask_input_options={...t,password:!0}:(0,a.R)(7,t)}},session_trace:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},soft_navigations:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},spa:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},ssl:void 0,user_actions:{enabled:!0}}},l={},f="All configuration objects require an agent identifier!";function h(e){if(!e)throw new Error(f);if(!l[e])throw new Error("Configuration for ".concat(e," was never set"));return l[e]}function p(e,t){if(!e)throw new Error(f);l[e]=(0,c.a)(t,d());const r=(0,s.nY)(e);r&&(r.init=l[e])}function g(e,t){if(!e)throw new Error(f);var r=h(e);if(r){for(var n=t.split("."),i=0;i<n.length-1;i++)if("object"!=typeof(r=r[n[i]]))return;r=r[n[n.length-1]]}return r}},5603:(e,t,r)=>{"use strict";r.d(t,{a:()=>c,o:()=>s});var n=r(384),i=r(8122);const o={accountID:void 0,trustKey:void 0,agentID:void 0,licenseKey:void 0,applicationID:void 0,xpid:void 0},a={};function s(e){if(!e)throw new Error("All loader-config objects require an agent identifier!");if(!a[e])throw new Error("LoaderConfig for ".concat(e," was never set"));return a[e]}function c(e,t){if(!e)throw new Error("All loader-config objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.loader_config=a[e])}},3371:(e,t,r)=>{"use strict";r.d(t,{V:()=>f,f:()=>l});var n=r(8122),i=r(384),o=r(6154),a=r(9324);let s=0;const c={buildEnv:a.F3,distMethod:a.Xs,version:a.xv,originTime:o.WN},u={customTransaction:void 0,disabled:!1,isolatedBacklog:!1,loaderType:void 0,maxBytes:3e4,onerror:void 0,ptid:void 0,releaseIds:{},appMetadata:{},session:void 0,denyList:void 0,timeKeeper:void 0,obfuscator:void 0},d={};function l(e){if(!e)throw new Error("All runtime objects require an agent identifier!");if(!d[e])throw new Error("Runtime for ".concat(e," was never set"));return d[e]}function f(e,t){if(!e)throw new Error("All runtime objects require an agent identifier!");d[e]={...(0,n.a)(t,u),...c},Object.hasOwnProperty.call(d[e],"harvestCount")||Object.defineProperty(d[e],"harvestCount",{get:()=>++s});const r=(0,i.nY)(e);r&&(r.runtime=d[e])}},9324:(e,t,r)=>{"use strict";r.d(t,{F3:()=>i,Xs:()=>o,Yq:()=>a,xv:()=>n});const n="1.274.0",i="PROD",o="CDN",a="^2.0.0-alpha.17"},6154:(e,t,r)=>{"use strict";r.d(t,{A4:()=>s,OF:()=>d,RI:()=>i,WN:()=>h,bv:()=>o,gm:()=>a,lR:()=>f,m:()=>u,mw:()=>c,sb:()=>l});var n=r(1863);const i="undefined"!=typeof window&&!!window.document,o="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),a=i?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),s="complete"===a?.document?.readyState,c=Boolean("hidden"===a?.document?.visibilityState),u=""+a?.location,d=/iPad|iPhone|iPod/.test(a.navigator?.userAgent),l=d&&"undefined"==typeof SharedWorker,f=(()=>{const e=a.navigator?.userAgent?.match(/Firefox[/\s](\d+\.\d+)/);return Array.isArray(e)&&e.length>=2?+e[1]:0})(),h=Date.now()-(0,n.t)()},7295:(e,t,r)=>{"use strict";r.d(t,{Xv:()=>a,gX:()=>i,iW:()=>o});var n=[];function i(e){if(!e||o(e))return!1;if(0===n.length)return!0;for(var t=0;t<n.length;t++){var r=n[t];if("*"===r.hostname)return!1;if(s(r.hostname,e.hostname)&&c(r.pathname,e.pathname))return!1}return!0}function o(e){return void 0===e.hostname}function a(e){if(n=[],e&&e.length)for(var t=0;t<e.length;t++){let r=e[t];if(!r)continue;0===r.indexOf("http://")?r=r.substring(7):0===r.indexOf("https://")&&(r=r.substring(8));const i=r.indexOf("/");let o,a;i>0?(o=r.substring(0,i),a=r.substring(i)):(o=r,a="");let[s]=o.split(":");n.push({hostname:s,pathname:a})}}function s(e,t){return!(e.length>t.length)&&t.indexOf(e)===t.length-e.length}function c(e,t){return 0===e.indexOf("/")&&(e=e.substring(1)),0===t.indexOf("/")&&(t=t.substring(1)),""===e||e===t}},1687:(e,t,r)=>{"use strict";r.d(t,{Ak:()=>c,Ze:()=>l,x3:()=>u});var n=r(7836),i=r(3606),o=r(860),a=r(2646);const s={};function c(e,t){const r={staged:!1,priority:o.P3[t]||0};d(e),s[e].get(t)||s[e].set(t,r)}function u(e,t){e&&s[e]&&(s[e].get(t)&&s[e].delete(t),h(e,t,!1),s[e].size&&f(e))}function d(e){if(!e)throw new Error("agentIdentifier required");s[e]||(s[e]=new Map)}function l(e="",t="feature",r=!1){if(d(e),!e||!s[e].get(t)||r)return h(e,t);s[e].get(t).staged=!0,f(e)}function f(e){const t=Array.from(s[e]);t.every((([e,t])=>t.staged))&&(t.sort(((e,t)=>e[1].priority-t[1].priority)),t.forEach((([t])=>{s[e].delete(t),h(e,t)})))}function h(e,t,r=!0){const o=e?n.ee.get(e):n.ee,s=i.i.handlers;if(!o.aborted&&o.backlog&&s){if(r){const e=o.backlog[t],r=s[t];if(r){for(let t=0;e&&t<e.length;++t)p(e[t],r);Object.entries(r).forEach((([e,t])=>{Object.values(t||{}).forEach((t=>{t[0]?.on&&t[0]?.context()instanceof a.y&&t[0].on(e,t[1])}))}))}}o.isolatedBacklog||delete s[t],o.backlog[t]=null,o.emit("drain-"+t,[])}}function p(e,t){var r=e[1];Object.values(t[r]||{}).forEach((t=>{var r=e[0];if(t[0]===r){var n=t[1],i=e[3],o=e[2];n.apply(i,o)}}))}},7836:(e,t,r)=>{"use strict";r.d(t,{P:()=>c,ee:()=>u});var n=r(384),i=r(8990),o=r(3371),a=r(2646),s=r(5607);const c="nr@context:".concat(s.W),u=function e(t,r){var n={},s={},d={},l=!1;try{l=16===r.length&&(0,o.f)(r).isolatedBacklog}catch(e){}var f={on:p,addEventListener:p,removeEventListener:function(e,t){var r=n[e];if(!r)return;for(var i=0;i<r.length;i++)r[i]===t&&r.splice(i,1)},emit:function(e,r,n,i,o){!1!==o&&(o=!0);if(u.aborted&&!i)return;t&&o&&t.emit(e,r,n);for(var a=h(n),c=g(e),d=c.length,l=0;l<d;l++)c[l].apply(a,r);var p=v()[s[e]];p&&p.push([f,e,r,a]);return a},get:m,listeners:g,context:h,buffer:function(e,t){const r=v();if(t=t||"feature",f.aborted)return;Object.entries(e||{}).forEach((([e,n])=>{s[n]=t,t in r||(r[t]=[])}))},abort:function(){f._aborted=!0,Object.keys(f.backlog).forEach((e=>{delete f.backlog[e]}))},isBuffering:function(e){return!!v()[s[e]]},debugId:r,backlog:l?{}:t&&"object"==typeof t.backlog?t.backlog:{},isolatedBacklog:l};return Object.defineProperty(f,"aborted",{get:()=>{let e=f._aborted||!1;return e||(t&&(e=t.aborted),e)}}),f;function h(e){return e&&e instanceof a.y?e:e?(0,i.I)(e,c,(()=>new a.y(c))):new a.y(c)}function p(e,t){n[e]=g(e).concat(t)}function g(e){return n[e]||[]}function m(t){return d[t]=d[t]||e(f,t)}function v(){return f.backlog}}(void 0,"globalEE"),d=(0,n.Zm)();d.ee||(d.ee=u)},2646:(e,t,r)=>{"use strict";r.d(t,{y:()=>n});class n{constructor(e){this.contextId=e}}},9908:(e,t,r)=>{"use strict";r.d(t,{d:()=>n,p:()=>i});var n=r(7836).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},3606:(e,t,r)=>{"use strict";r.d(t,{i:()=>o});var n=r(9908);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.d,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.d);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},3878:(e,t,r)=>{"use strict";function n(e,t){return{capture:e,passive:!1,signal:t}}function i(e,t,r=!1,i){window.addEventListener(e,t,n(r,i))}function o(e,t,r=!1,i){document.addEventListener(e,t,n(r,i))}r.d(t,{DD:()=>o,jT:()=>n,sp:()=>i})},5607:(e,t,r)=>{"use strict";r.d(t,{W:()=>n});const n=(0,r(9566).bz)()},9566:(e,t,r)=>{"use strict";r.d(t,{LA:()=>s,ZF:()=>c,bz:()=>a,el:()=>u});var n=r(6154);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n.gm?.crypto||n.gm?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(30))),i.split("").map((e=>"x"===e?o(t,r++).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n.gm?.crypto||n.gm?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(e)));const a=[];for(var s=0;s<e;s++)a.push(o(r,i++).toString(16));return a.join("")}function c(){return s(16)}function u(){return s(32)}},2614:(e,t,r)=>{"use strict";r.d(t,{BB:()=>a,H3:()=>n,g:()=>u,iL:()=>c,tS:()=>s,uh:()=>i,wk:()=>o});const n="NRBA",i="SESSION",o=144e5,a=18e5,s={STARTED:"session-started",PAUSE:"session-pause",RESET:"session-reset",RESUME:"session-resume",UPDATE:"session-update"},c={SAME_TAB:"same-tab",CROSS_TAB:"cross-tab"},u={OFF:0,FULL:1,ERROR:2}},1863:(e,t,r)=>{"use strict";function n(){return Math.floor(performance.now())}r.d(t,{t:()=>n})},7485:(e,t,r)=>{"use strict";r.d(t,{D:()=>i});var n=r(6154);function i(e){if(0===(e||"").indexOf("data:"))return{protocol:"data"};try{const t=new URL(e,location.href),r={port:t.port,hostname:t.hostname,pathname:t.pathname,search:t.search,protocol:t.protocol.slice(0,t.protocol.indexOf(":")),sameOrigin:t.protocol===n.gm?.location?.protocol&&t.host===n.gm?.location?.host};return r.port&&""!==r.port||("http:"===t.protocol&&(r.port="80"),"https:"===t.protocol&&(r.port="443")),r.pathname&&""!==r.pathname?r.pathname.startsWith("/")||(r.pathname="/".concat(r.pathname)):r.pathname="/",r}catch(e){return{}}}},944:(e,t,r)=>{"use strict";function n(e,t){"function"==typeof console.debug&&console.debug("New Relic Warning: https://github.com/newrelic/newrelic-browser-agent/blob/main/docs/warning-codes.md#".concat(e),t)}r.d(t,{R:()=>n})},5284:(e,t,r)=>{"use strict";r.d(t,{t:()=>c,B:()=>s});var n=r(7836),i=r(6154);const o="newrelic";const a=new Set,s={};function c(e,t){const r=n.ee.get(t);s[t]??={},e&&"object"==typeof e&&(a.has(t)||(r.emit("rumresp",[e]),s[t]=e,a.add(t),function(e={}){try{i.gm.dispatchEvent(new CustomEvent(o,{detail:e}))}catch(e){}}({loaded:!0})))}},8990:(e,t,r)=>{"use strict";r.d(t,{I:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},6389:(e,t,r)=>{"use strict";function n(e,t=500,r={}){const n=r?.leading||!1;let i;return(...r)=>{n&&void 0===i&&(e.apply(this,r),i=setTimeout((()=>{i=clearTimeout(i)}),t)),n||(clearTimeout(i),i=setTimeout((()=>{e.apply(this,r)}),t))}}function i(e){let t=!1;return(...r)=>{t||(t=!0,e.apply(this,r))}}r.d(t,{J:()=>i,s:()=>n})},3304:(e,t,r)=>{"use strict";r.d(t,{A:()=>o});var n=r(7836);const i=()=>{const e=new WeakSet;return(t,r)=>{if("object"==typeof r&&null!==r){if(e.has(r))return;e.add(r)}return r}};function o(e){try{return JSON.stringify(e,i())??""}catch(e){try{n.ee.emit("internal-error",[e])}catch(e){}return""}}},5289:(e,t,r)=>{"use strict";r.d(t,{GG:()=>o,sB:()=>a});var n=r(3878);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.sp)("load",e,t)}function a(e){if(i())return e();(0,n.DD)("DOMContentLoaded",e)}},384:(e,t,r)=>{"use strict";r.d(t,{NT:()=>o,US:()=>d,Zm:()=>a,bQ:()=>c,dV:()=>s,nY:()=>u,pV:()=>l});var n=r(6154),i=r(1863);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return n.gm.NREUM||(n.gm.NREUM={}),void 0===n.gm.newrelic&&(n.gm.newrelic=n.gm.NREUM),n.gm.NREUM}function s(){let e=a();return e.o||(e.o={ST:n.gm.setTimeout,SI:n.gm.setImmediate,CT:n.gm.clearTimeout,XHR:n.gm.XMLHttpRequest,REQ:n.gm.Request,EV:n.gm.Event,PR:n.gm.Promise,MO:n.gm.MutationObserver,FETCH:n.gm.fetch,WS:n.gm.WebSocket}),e}function c(e,t){let r=a();r.initializedAgents??={},t.initializedAt={ms:(0,i.t)(),date:new Date},r.initializedAgents[e]=t}function u(e){let t=a();return t.initializedAgents?.[e]}function d(e,t){a()[e]=t}function l(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},2843:(e,t,r)=>{"use strict";r.d(t,{u:()=>i});var n=r(3878);function i(e,t=!1,r,i){(0,n.DD)("visibilitychange",(function(){if(t)return void("hidden"===document.visibilityState&&e());e(document.visibilityState)}),r,i)}},8139:(e,t,r)=>{"use strict";r.d(t,{u:()=>f});var n=r(7836),i=r(3434),o=r(8990),a=r(6154);const s={},c=a.gm.XMLHttpRequest,u="addEventListener",d="removeEventListener",l="nr@wrapped:".concat(n.P);function f(e){var t=function(e){return(e||n.ee).get("events")}(e);if(s[t.debugId]++)return t;s[t.debugId]=1;var r=(0,i.YM)(t,!0);function f(e){r.inPlace(e,[u,d],"-",p)}function p(e,t){return e[1]}return"getPrototypeOf"in Object&&(a.RI&&h(document,f),h(a.gm,f),h(c.prototype,f)),t.on(u+"-start",(function(e,t){var n=e[1];if(null!==n&&("function"==typeof n||"object"==typeof n)){var i=(0,o.I)(n,l,(function(){var e={object:function(){if("function"!=typeof n.handleEvent)return;return n.handleEvent.apply(n,arguments)},function:n}[typeof n];return e?r(e,"fn-",null,e.name||"anonymous"):n}));this.wrapped=e[1]=i}})),t.on(d+"-start",(function(e){e[1]=this.wrapped||e[1]})),t}function h(e,t,...r){let n=e;for(;"object"==typeof n&&!Object.prototype.hasOwnProperty.call(n,u);)n=Object.getPrototypeOf(n);n&&t(n,...r)}},3434:(e,t,r)=>{"use strict";r.d(t,{Jt:()=>o,YM:()=>c});var n=r(7836),i=r(5607);const o="nr@original:".concat(i.W);var a=Object.prototype.hasOwnProperty,s=!1;function c(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");const a="-"===n.charAt(0);for(let s=0;s<t.length;s++){const c=t[s],u=e[c];d(u)||(e[c]=r(u,a?c+n:n,i,c,o))}},r.flag=o,r;function r(t,r,n,s,c){return d(t)?t:(r||(r=""),nrWrapper[o]=t,function(e,t,r){if(Object.defineProperty&&Object.keys)try{return Object.keys(e).forEach((function(r){Object.defineProperty(t,r,{get:function(){return e[r]},set:function(t){return e[r]=t,t}})})),t}catch(e){u([e],r)}for(var n in e)a.call(e,n)&&(t[n]=e[n])}(t,nrWrapper,e),nrWrapper);function nrWrapper(){var o,a,d,l;try{a=this,o=[...arguments],d="function"==typeof n?n(o,a):n||{}}catch(t){u([t,"",[o,a,s],d],e)}i(r+"start",[o,a,s],d,c);try{return l=t.apply(a,o)}catch(e){throw i(r+"err",[o,a,e],d,c),e}finally{i(r+"end",[o,a,l],d,c)}}}function i(r,n,i,o){if(!s||t){var a=s;s=!0;try{e.emit(r,n,i,t,o)}catch(t){u([t,r,n,i],e)}s=a}}}function u(e,t){t||(t=n.ee);try{t.emit("internal-error",e)}catch(e){}}function d(e){return!(e&&"function"==typeof e&&e.apply&&!e[o])}},9300:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.ajax},3333:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,Zp:()=>i,mq:()=>s,nf:()=>a,qN:()=>o});const n=r(860).K7.genericEvents,i=["auxclick","click","copy","keydown","paste","scrollend"],o=["focus","blur"],a=4,s=1e3},6774:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.jserrors},993:(e,t,r)=>{"use strict";r.d(t,{ET:()=>o,TZ:()=>a,p_:()=>i});var n=r(860);const i={ERROR:"ERROR",WARN:"WARN",INFO:"INFO",DEBUG:"DEBUG",TRACE:"TRACE"},o="log",a=n.K7.logging},3785:(e,t,r)=>{"use strict";r.d(t,{R:()=>c,b:()=>u});var n=r(9908),i=r(1863),o=r(860),a=r(3969),s=r(993);function c(e,t,r={},c=s.p_.INFO){(0,n.p)(a.xV,["API/logging/".concat(c.toLowerCase(),"/called")],void 0,o.K7.metrics,e),(0,n.p)(s.ET,[(0,i.t)(),t,r,c],void 0,o.K7.logging,e)}function u(e){return"string"==typeof e&&Object.values(s.p_).some((t=>t===e.toUpperCase().trim()))}},3969:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,XG:()=>s,rs:()=>i,xV:()=>a,z_:()=>o});const n=r(860).K7.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},6630:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewEvent},782:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewTiming},6344:(e,t,r)=>{"use strict";r.d(t,{BB:()=>d,G4:()=>o,Qb:()=>l,TZ:()=>i,Ug:()=>a,_s:()=>s,bc:()=>u,yP:()=>c});var n=r(2614);const i=r(860).K7.sessionReplay,o={RECORD:"recordReplay",PAUSE:"pauseReplay",REPLAY_RUNNING:"replayRunning",ERROR_DURING_REPLAY:"errorDuringReplay"},a=.12,s={DomContentLoaded:0,Load:1,FullSnapshot:2,IncrementalSnapshot:3,Meta:4,Custom:5},c={[n.g.ERROR]:15e3,[n.g.FULL]:3e5,[n.g.OFF]:0},u={RESET:{message:"Session was reset",sm:"Reset"},IMPORT:{message:"Recorder failed to import",sm:"Import"},TOO_MANY:{message:"429: Too Many Requests",sm:"Too-Many"},TOO_BIG:{message:"Payload was too large",sm:"Too-Big"},CROSS_TAB:{message:"Session Entity was set to OFF on another tab",sm:"Cross-Tab"},ENTITLEMENTS:{message:"Session Replay is not allowed and will not be started",sm:"Entitlement"}},d=5e3,l={API:"api"}},5270:(e,t,r)=>{"use strict";r.d(t,{Aw:()=>c,CT:()=>u,SR:()=>s});var n=r(384),i=r(9417),o=r(7767),a=r(6154);function s(e){return!!(0,n.dV)().o.MO&&(0,o.V)(e)&&!0===(0,i.gD)(e,"session_trace.enabled")}function c(e){return!0===(0,i.gD)(e,"session_replay.preload")&&s(e)}function u(e,t){const r=t.correctAbsoluteTimestamp(e);return{originalTimestamp:e,correctedTimestamp:r,timestampDiff:e-r,originTime:a.WN,correctedOriginTime:t.correctedOriginTime,originTimeDiff:Math.floor(a.WN-t.correctedOriginTime)}}},3738:(e,t,r)=>{"use strict";r.d(t,{He:()=>i,Kp:()=>s,Lc:()=>u,Rz:()=>d,TZ:()=>n,bD:()=>o,d3:()=>a,jx:()=>l,uP:()=>c});const n=r(860).K7.sessionTrace,i="bstResource",o="resource",a="-start",s="-end",c="fn"+a,u="fn"+s,d="pushState",l=1e3},3962:(e,t,r)=>{"use strict";r.d(t,{AM:()=>o,O2:()=>s,Qu:()=>c,TZ:()=>a,ih:()=>u,tC:()=>i});var n=r(860);const i=["click","keydown","submit"],o="api",a=n.K7.softNav,s={INITIAL_PAGE_LOAD:"",ROUTE_CHANGE:1,UNSPECIFIED:2},c={INTERACTION:1,AJAX:2,CUSTOM_END:3,CUSTOM_TRACER:4},u={IP:"in progress",FIN:"finished",CAN:"cancelled"}},7378:(e,t,r)=>{"use strict";r.d(t,{$p:()=>x,BR:()=>b,Kp:()=>R,L3:()=>y,Lc:()=>c,NC:()=>o,SG:()=>d,TZ:()=>i,U6:()=>p,UT:()=>m,d3:()=>w,dT:()=>f,e5:()=>A,gx:()=>v,l9:()=>l,oW:()=>h,op:()=>g,rw:()=>u,tH:()=>E,uP:()=>s,wW:()=>T,xq:()=>a});var n=r(384);const i=r(860).K7.spa,o=["click","submit","keypress","keydown","keyup","change"],a=999,s="fn-start",c="fn-end",u="cb-start",d="api-ixn-",l="remaining",f="interaction",h="spaNode",p="jsonpNode",g="fetch-start",m="fetch-done",v="fetch-body-",b="jsonp-end",y=(0,n.dV)().o.ST,w="-start",R="-end",x="-body",T="cb"+R,A="jsTime",E="fetch"},4234:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(7836),i=r(1687);class o{constructor(e,t){this.agentIdentifier=e,this.ee=n.ee.get(e),this.featureName=t,this.blocked=!1}deregisterDrain(){(0,i.x3)(this.agentIdentifier,this.featureName)}}},7767:(e,t,r)=>{"use strict";r.d(t,{V:()=>o});var n=r(9417),i=r(6154);const o=e=>i.RI&&!0===(0,n.gD)(e,"privacy.cookies_enabled")},425:(e,t,r)=>{"use strict";r.d(t,{j:()=>j});var n=r(860),i=r(2555),o=r(3371),a=r(9908),s=r(7836),c=r(1687),u=r(5289),d=r(6154),l=r(944),f=r(3969),h=r(384),p=r(6344);const g=["setErrorHandler","finished","addToTrace","addRelease","addPageAction","setCurrentRouteName","setPageViewName","setCustomAttribute","interaction","noticeError","setUserId","setApplicationVersion","start",p.G4.RECORD,p.G4.PAUSE,"log","wrapLogger"],m=["setErrorHandler","finished","addToTrace","addRelease"];var v=r(1863),b=r(2614),y=r(993),w=r(3785),R=r(2646),x=r(3434);function T(e,t,r,n){if("object"!=typeof t||!t||"string"!=typeof r||!r||"function"!=typeof t[r])return(0,l.R)(29);const i=function(e){return(e||s.ee).get("logger")}(e),o=(0,x.YM)(i),a=new R.y(s.P);return a.level=n.level,a.customAttributes=n.customAttributes,o.inPlace(t,[r],"wrap-logger-",a),i}function A(){const e=(0,h.pV)();g.forEach((t=>{e[t]=(...r)=>function(t,...r){let n=[];return Object.values(e.initializedAgents).forEach((e=>{e&&e.api?e.exposed&&e.api[t]&&n.push(e.api[t](...r)):(0,l.R)(38,t)})),n.length>1?n:n[0]}(t,...r)}))}const E={};var S=r(9417),N=r(5603),O=r(5284);const _=e=>{const t=e.startsWith("http");e+="/",r.p=t?e:"https://"+e};let I=!1;function j(e,t={},g,R){let{init:x,info:j,loader_config:P,runtime:C={},exposed:k=!0}=t;C.loaderType=g;const L=(0,h.pV)();j||(x=L.init,j=L.info,P=L.loader_config),(0,S.xN)(e.agentIdentifier,x||{}),(0,N.a)(e.agentIdentifier,P||{}),j.jsAttributes??={},d.bv&&(j.jsAttributes.isWorker=!0),(0,i.x1)(e.agentIdentifier,j);const H=(0,S.D0)(e.agentIdentifier),D=[j.beacon,j.errorBeacon];I||(H.proxy.assets&&(_(H.proxy.assets),D.push(H.proxy.assets)),H.proxy.beacon&&D.push(H.proxy.beacon),A(),(0,h.US)("activatedFeatures",O.B),e.runSoftNavOverSpa&&=!0===H.soft_navigations.enabled&&H.feature_flags.includes("soft_nav")),C.denyList=[...H.ajax.deny_list||[],...H.ajax.block_internal?D:[]],C.ptid=e.agentIdentifier,(0,o.V)(e.agentIdentifier,C),e.ee=s.ee.get(e.agentIdentifier),void 0===e.api&&(e.api=function(e,t,h=!1){t||(0,c.Ak)(e,"api");const g={};var R=s.ee.get(e),x=R.get("tracer");E[e]=b.g.OFF,R.on(p.G4.REPLAY_RUNNING,(t=>{E[e]=t}));var A="api-",S=A+"ixn-";function N(t,r,n,o){const a=(0,i.Vp)(e);return null===r?delete a.jsAttributes[t]:(0,i.x1)(e,{...a,jsAttributes:{...a.jsAttributes,[t]:r}}),I(A,n,!0,o||null===r?"session":void 0)(t,r)}function O(){}g.log=function(e,{customAttributes:t={},level:r=y.p_.INFO}={}){(0,a.p)(f.xV,["API/log/called"],void 0,n.K7.metrics,R),(0,w.R)(R,e,t,r)},g.wrapLogger=(e,t,{customAttributes:r={},level:i=y.p_.INFO}={})=>{(0,a.p)(f.xV,["API/wrapLogger/called"],void 0,n.K7.metrics,R),T(R,e,t,{customAttributes:r,level:i})},m.forEach((e=>{g[e]=I(A,e,!0,"api")})),g.addPageAction=I(A,"addPageAction",!0,n.K7.genericEvents),g.setPageViewName=function(t,r){if("string"==typeof t)return"/"!==t.charAt(0)&&(t="/"+t),(0,o.f)(e).customTransaction=(r||"http://custom.transaction")+t,I(A,"setPageViewName",!0)()},g.setCustomAttribute=function(e,t,r=!1){if("string"==typeof e){if(["string","number","boolean"].includes(typeof t)||null===t)return N(e,t,"setCustomAttribute",r);(0,l.R)(40,typeof t)}else(0,l.R)(39,typeof e)},g.setUserId=function(e){if("string"==typeof e||null===e)return N("enduser.id",e,"setUserId",!0);(0,l.R)(41,typeof e)},g.setApplicationVersion=function(e){if("string"==typeof e||null===e)return N("application.version",e,"setApplicationVersion",!1);(0,l.R)(42,typeof e)},g.start=()=>{try{(0,a.p)(f.xV,["API/start/called"],void 0,n.K7.metrics,R),R.emit("manual-start-all")}catch(e){(0,l.R)(23,e)}},g[p.G4.RECORD]=function(){(0,a.p)(f.xV,["API/recordReplay/called"],void 0,n.K7.metrics,R),(0,a.p)(p.G4.RECORD,[],void 0,n.K7.sessionReplay,R)},g[p.G4.PAUSE]=function(){(0,a.p)(f.xV,["API/pauseReplay/called"],void 0,n.K7.metrics,R),(0,a.p)(p.G4.PAUSE,[],void 0,n.K7.sessionReplay,R)},g.interaction=function(e){return(new O).get("object"==typeof e?e:{})};const _=O.prototype={createTracer:function(e,t){var r={},i=this,o="function"==typeof t;return(0,a.p)(f.xV,["API/createTracer/called"],void 0,n.K7.metrics,R),h||(0,a.p)(S+"tracer",[(0,v.t)(),e,r],i,n.K7.spa,R),function(){if(x.emit((o?"":"no-")+"fn-start",[(0,v.t)(),i,o],r),o)try{return t.apply(this,arguments)}catch(e){const t="string"==typeof e?new Error(e):e;throw x.emit("fn-err",[arguments,this,t],r),t}finally{x.emit("fn-end",[(0,v.t)()],r)}}}};function I(e,t,r,i){return function(){return(0,a.p)(f.xV,["API/"+t+"/called"],void 0,n.K7.metrics,R),i&&(0,a.p)(e+t,[(0,v.t)(),...arguments],r?null:this,i,R),r?void 0:this}}function j(){r.e(478).then(r.bind(r,8778)).then((({setAPI:t})=>{t(e),(0,c.Ze)(e,"api")})).catch((e=>{(0,l.R)(27,e),R.abort()}))}return["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((e=>{_[e]=I(S,e,void 0,h?n.K7.softNav:n.K7.spa)})),g.setCurrentRouteName=h?I(S,"routeName",void 0,n.K7.softNav):I(A,"routeName",!0,n.K7.spa),g.noticeError=function(t,r){"string"==typeof t&&(t=new Error(t)),(0,a.p)(f.xV,["API/noticeError/called"],void 0,n.K7.metrics,R),(0,a.p)("err",[t,(0,v.t)(),!1,r,!!E[e]],void 0,n.K7.jserrors,R)},d.RI?(0,u.GG)((()=>j()),!0):j(),g}(e.agentIdentifier,R,e.runSoftNavOverSpa)),void 0===e.exposed&&(e.exposed=k),I=!0}},8374:(e,t,r)=>{r.nc=(()=>{try{return document?.currentScript?.nonce}catch(e){}return""})()},860:(e,t,r)=>{"use strict";r.d(t,{$J:()=>o,K7:()=>n,P3:()=>i});const n={ajax:"ajax",genericEvents:"generic_events",jserrors:"jserrors",logging:"logging",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",softNav:"soft_navigations",spa:"spa"},i={[n.pageViewEvent]:1,[n.pageViewTiming]:2,[n.metrics]:3,[n.jserrors]:4,[n.spa]:5,[n.ajax]:6,[n.sessionTrace]:7,[n.softNav]:8,[n.sessionReplay]:9,[n.logging]:10,[n.genericEvents]:11},o={[n.pageViewTiming]:"events",[n.ajax]:"events",[n.spa]:"events",[n.softNav]:"events",[n.metrics]:"jserrors",[n.jserrors]:"jserrors",[n.sessionTrace]:"browser/blobs",[n.sessionReplay]:"browser/blobs",[n.logging]:"browser/logs",[n.genericEvents]:"ins"}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>({212:"nr-spa-compressor",249:"nr-spa-recorder",478:"nr-spa"}[e]+"-1.274.0.min.js"),i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA-1.274.0.PROD:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var u=document.getElementsByTagName("script"),d=0;d<u.length;d++){var l=u[d];if(l.getAttribute("src")==r||l.getAttribute("data-webpack")==t+o){s=l;break}}if(!s){c=!0;var f={478:"sha512-1vUqEfJPB8Pihje9mv5CfYgkitO1FWcS+UQb84DbXqP8oYctRv4/lzl/MzNLPlRhcY1WVDBGL20I8vm6s2VV7g==",249:"sha512-Y/BeZAh6VSTmUtUNmS5XdyKxL92s30Fyyj8xVW76HSPxcKItL4+x2+kGMZc8pMJnUpZDz1L4eftZQAJh3D8NnA==",212:"sha512-Gn2tQ3qog5Yhrx/gRutkSTYPp+7nkKFt4/mIXg99LxcNpMDAYJZDBYmAACdoHNM86+iq1F3cBcQotFNzjIX8bw=="};(s=document.createElement("script")).charset="utf-8",s.timeout=120,i.nc&&s.setAttribute("nonce",i.nc),s.setAttribute("data-webpack",t+o),s.src=r,0!==s.src.indexOf(window.location.origin+"/")&&(s.crossOrigin="anonymous"),f[a]&&(s.integrity=f[a])}e[r]=[n];var h=(t,n)=>{s.onerror=s.onload=null,clearTimeout(p);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},p=setTimeout(h.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=h.bind(null,s.onerror),s.onload=h.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.p="https://js-agent.newrelic.com/",(()=>{var e={38:0,788:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,u=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);u<a.length;u++)o=a[u],i.o(e,o)&&e[o]&&e[o][0](),e[o]=0},r=self["webpackChunk:NRBA-1.274.0.PROD"]=self["webpackChunk:NRBA-1.274.0.PROD"]||[];r.forEach(t.bind(null,0)),r.push=t.bind(null,r.push.bind(r))})(),(()=>{"use strict";i(8374);var e=i(944),t=i(6344),r=i(9566);class n{agentIdentifier;constructor(e=(0,r.LA)(16)){this.agentIdentifier=e}#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}addPageAction(e,t){return this.#e("addPageAction",e,t)}setPageViewName(e,t){return this.#e("setPageViewName",e,t)}setCustomAttribute(e,t,r){return this.#e("setCustomAttribute",e,t,r)}noticeError(e,t){return this.#e("noticeError",e,t)}setUserId(e){return this.#e("setUserId",e)}setApplicationVersion(e){return this.#e("setApplicationVersion",e)}setErrorHandler(e){return this.#e("setErrorHandler",e)}addRelease(e,t){return this.#e("addRelease",e,t)}log(e,t){return this.#e("log",e,t)}}class o extends n{#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}start(){return this.#e("start")}finished(e){return this.#e("finished",e)}recordReplay(){return this.#e(t.G4.RECORD)}pauseReplay(){return this.#e(t.G4.PAUSE)}addToTrace(e){return this.#e("addToTrace",e)}setCurrentRouteName(e){return this.#e("setCurrentRouteName",e)}interaction(){return this.#e("interaction")}wrapLogger(e,t,r){return this.#e("wrapLogger",e,t,r)}}var a=i(860),s=i(9417);const c=Object.values(a.K7);function u(e){const t={};return c.forEach((r=>{t[r]=function(e,t){return!0===(0,s.gD)(t,"".concat(e,".enabled"))}(r,e)})),t}var d=i(425);var l=i(1687),f=i(4234),h=i(5289),p=i(6154),g=i(5270),m=i(7767),v=i(6389);class b extends f.W{constructor(e,t,r=!0){super(e.agentIdentifier,t),this.auto=r,this.abortHandler=void 0,this.featAggregate=void 0,this.onAggregateImported=void 0,!1===e.init[this.featureName].autoStart&&(this.auto=!1),this.auto?(0,l.Ak)(e.agentIdentifier,t):this.ee.on("manual-start-all",(0,v.J)((()=>{(0,l.Ak)(e.agentIdentifier,this.featureName),this.auto=!0,this.importAggregator(e)})))}importAggregator(t,r={}){if(this.featAggregate||!this.auto)return;let n;this.onAggregateImported=new Promise((e=>{n=e}));const o=async()=>{let o;try{if((0,m.V)(this.agentIdentifier)){const{setupAgentSession:e}=await i.e(478).then(i.bind(i,6526));o=e(t)}}catch(t){(0,e.R)(20,t),this.ee.emit("internal-error",[t]),this.featureName===a.K7.sessionReplay&&this.abortHandler?.()}try{if(t.sharedAggregator)await t.sharedAggregator;else{t.sharedAggregator=i.e(478).then(i.bind(i,9337));const{EventAggregator:e}=await t.sharedAggregator;t.sharedAggregator=new e}if(!this.#t(this.featureName,o))return(0,l.Ze)(this.agentIdentifier,this.featureName),void n(!1);const{lazyFeatureLoader:e}=await i.e(478).then(i.bind(i,6103)),{Aggregate:a}=await e(this.featureName,"aggregate");this.featAggregate=new a(t,r),n(!0)}catch(t){(0,e.R)(34,t),this.abortHandler?.(),(0,l.Ze)(this.agentIdentifier,this.featureName,!0),n(!1),this.ee&&this.ee.abort()}};p.RI?(0,h.GG)((()=>o()),!0):o()}#t(e,t){switch(e){case a.K7.sessionReplay:return(0,g.SR)(this.agentIdentifier)&&!!t;case a.K7.sessionTrace:return!!t;default:return!0}}}var y=i(6630);class w extends b{static featureName=y.T;constructor(e,t=!0){super(e,y.T,t),this.importAggregator(e)}}var R=i(384);var x=i(9908),T=i(2843),A=i(3878),E=i(782),S=i(1863);class N extends b{static featureName=E.T;constructor(e,t=!0){super(e,E.T,t),p.RI&&((0,T.u)((()=>(0,x.p)("docHidden",[(0,S.t)()],void 0,E.T,this.ee)),!0),(0,A.sp)("pagehide",(()=>(0,x.p)("winPagehide",[(0,S.t)()],void 0,E.T,this.ee))),this.importAggregator(e))}}var O=i(3969);class _ extends b{static featureName=O.TZ;constructor(e,t=!0){super(e,O.TZ,t),this.importAggregator(e)}}var I=i(6774),j=i(3304);class P{constructor(e,t,r,n,i){this.name="UncaughtError",this.message="string"==typeof e?e:(0,j.A)(e),this.sourceURL=t,this.line=r,this.column=n,this.__newrelic=i}}function C(e){return H(e)?e:new P(void 0!==e?.message?e.message:e,e?.filename||e?.sourceURL,e?.lineno||e?.line,e?.colno||e?.col,e?.__newrelic)}function k(e){const t="Unhandled Promise Rejection";if(!e?.reason)return;if(H(e.reason))try{return e.reason.message=t+": "+e.reason.message,C(e.reason)}catch(t){return C(e.reason)}const r=C(e.reason);return r.message=t+": "+r?.message,r}function L(e){if(e.error instanceof SyntaxError&&!/:\d+$/.test(e.error.stack?.trim())){const t=new P(e.message,e.filename,e.lineno,e.colno,e.error.__newrelic);return t.name=SyntaxError.name,t}return H(e.error)?e.error:C(e)}function H(e){return e instanceof Error&&!!e.stack}class D extends b{static featureName=I.T;#r=!1;constructor(e,r=!0){super(e,I.T,r);try{this.removeOnAbort=new AbortController}catch(e){}this.ee.on("internal-error",(e=>{this.abortHandler&&(0,x.p)("ierr",[C(e),(0,S.t)(),!0,{},this.#r],void 0,this.featureName,this.ee)})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.#r=e})),p.gm.addEventListener("unhandledrejection",(e=>{this.abortHandler&&(0,x.p)("err",[k(e),(0,S.t)(),!1,{unhandledPromiseRejection:1},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),p.gm.addEventListener("error",(e=>{this.abortHandler&&(0,x.p)("err",[L(e),(0,S.t)(),!1,{},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),this.abortHandler=this.#n,this.importAggregator(e)}#n(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var M=i(8990);let K=1;const U="nr@id";function V(e){const t=typeof e;return!e||"object"!==t&&"function"!==t?-1:e===p.gm?0:(0,M.I)(e,U,(function(){return K++}))}function G(e){if("string"==typeof e&&e.length)return e.length;if("object"==typeof e){if("undefined"!=typeof ArrayBuffer&&e instanceof ArrayBuffer&&e.byteLength)return e.byteLength;if("undefined"!=typeof Blob&&e instanceof Blob&&e.size)return e.size;if(!("undefined"!=typeof FormData&&e instanceof FormData))try{return(0,j.A)(e).length}catch(e){return}}}var F=i(8139),B=i(7836),W=i(3434);const z={},q=["open","send"];function Z(t){var r=t||B.ee;const n=function(e){return(e||B.ee).get("xhr")}(r);if(z[n.debugId]++)return n;z[n.debugId]=1,(0,F.u)(r);var i=(0,W.YM)(n),o=p.gm.XMLHttpRequest,a=p.gm.MutationObserver,s=p.gm.Promise,c=p.gm.setInterval,u="readystatechange",d=["onload","onerror","onabort","onloadstart","onloadend","onprogress","ontimeout"],l=[],f=p.gm.XMLHttpRequest=function(t){const r=new o(t),a=n.context(r);try{n.emit("new-xhr",[r],a),r.addEventListener(u,(s=a,function(){var e=this;e.readyState>3&&!s.resolved&&(s.resolved=!0,n.emit("xhr-resolved",[],e)),i.inPlace(e,d,"fn-",y)}),(0,A.jT)(!1))}catch(t){(0,e.R)(15,t);try{n.emit("internal-error",[t])}catch(e){}}var s;return r};function h(e,t){i.inPlace(t,["onreadystatechange"],"fn-",y)}if(function(e,t){for(var r in e)t[r]=e[r]}(o,f),f.prototype=o.prototype,i.inPlace(f.prototype,q,"-xhr-",y),n.on("send-xhr-start",(function(e,t){h(e,t),function(e){l.push(e),a&&(g?g.then(b):c?c(b):(m=-m,v.data=m))}(t)})),n.on("open-xhr-start",h),a){var g=s&&s.resolve();if(!c&&!s){var m=1,v=document.createTextNode(m);new a(b).observe(v,{characterData:!0})}}else r.on("fn-end",(function(e){e[0]&&e[0].type===u||b()}));function b(){for(var e=0;e<l.length;e++)h(0,l[e]);l.length&&(l=[])}function y(e,t){return t}return n}var Y="fetch-",X=Y+"body-",J=["arrayBuffer","blob","json","text","formData"],Q=p.gm.Request,ee=p.gm.Response,te="prototype";const re={};function ne(e){const t=function(e){return(e||B.ee).get("fetch")}(e);if(!(Q&&ee&&p.gm.fetch))return t;if(re[t.debugId]++)return t;function r(e,r,n){var i=e[r];"function"==typeof i&&(e[r]=function(){var e,r=[...arguments],o={};t.emit(n+"before-start",[r],o),o[B.P]&&o[B.P].dt&&(e=o[B.P].dt);var a=i.apply(this,r);return t.emit(n+"start",[r,e],a),a.then((function(e){return t.emit(n+"end",[null,e],a),e}),(function(e){throw t.emit(n+"end",[e],a),e}))})}return re[t.debugId]=1,J.forEach((e=>{r(Q[te],e,X),r(ee[te],e,X)})),r(p.gm,"fetch",Y),t.on(Y+"end",(function(e,r){var n=this;if(r){var i=r.headers.get("content-length");null!==i&&(n.rxSize=i),t.emit(Y+"done",[null,r],n)}else t.emit(Y+"done",[e],n)})),t}var ie=i(7485),oe=i(5603);class ae{constructor(e){this.agentIdentifier=e}generateTracePayload(e){if(!this.shouldGenerateTrace(e))return null;var t=(0,oe.o)(this.agentIdentifier);if(!t)return null;var n=(t.accountID||"").toString()||null,i=(t.agentID||"").toString()||null,o=(t.trustKey||"").toString()||null;if(!n||!i)return null;var a=(0,r.ZF)(),s=(0,r.el)(),c=Date.now(),u={spanId:a,traceId:s,timestamp:c};return(e.sameOrigin||this.isAllowedOrigin(e)&&this.useTraceContextHeadersForCors())&&(u.traceContextParentHeader=this.generateTraceContextParentHeader(a,s),u.traceContextStateHeader=this.generateTraceContextStateHeader(a,c,n,i,o)),(e.sameOrigin&&!this.excludeNewrelicHeader()||!e.sameOrigin&&this.isAllowedOrigin(e)&&this.useNewrelicHeaderForCors())&&(u.newrelicHeader=this.generateTraceHeader(a,s,c,n,i,o)),u}generateTraceContextParentHeader(e,t){return"00-"+t+"-"+e+"-01"}generateTraceContextStateHeader(e,t,r,n,i){return i+"@nr=0-1-"+r+"-"+n+"-"+e+"----"+t}generateTraceHeader(e,t,r,n,i,o){if(!("function"==typeof p.gm?.btoa))return null;var a={v:[0,1],d:{ty:"Browser",ac:n,ap:i,id:e,tr:t,ti:r}};return o&&n!==o&&(a.d.tk=o),btoa((0,j.A)(a))}shouldGenerateTrace(e){return this.isDtEnabled()&&this.isAllowedOrigin(e)}isAllowedOrigin(e){var t=!1,r={};if((0,s.gD)(this.agentIdentifier,"distributed_tracing")&&(r=(0,s.D0)(this.agentIdentifier).distributed_tracing),e.sameOrigin)t=!0;else if(r.allowed_origins instanceof Array)for(var n=0;n<r.allowed_origins.length;n++){var i=(0,ie.D)(r.allowed_origins[n]);if(e.hostname===i.hostname&&e.protocol===i.protocol&&e.port===i.port){t=!0;break}}return t}isDtEnabled(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.enabled}excludeNewrelicHeader(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.exclude_newrelic_header}useNewrelicHeaderForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!1!==e.cors_use_newrelic_header}useTraceContextHeadersForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.cors_use_tracecontext_headers}}var se=i(9300),ce=i(7295),ue=["load","error","abort","timeout"],de=ue.length,le=(0,R.dV)().o.REQ,fe=(0,R.dV)().o.XHR;class he extends b{static featureName=se.T;constructor(e,t=!0){super(e,se.T,t),this.dt=new ae(e.agentIdentifier),this.handler=(e,t,r,n)=>(0,x.p)(e,t,r,n,this.ee);try{const e={xmlhttprequest:"xhr",fetch:"fetch",beacon:"beacon"};p.gm?.performance?.getEntriesByType("resource").forEach((t=>{if(t.initiatorType in e&&0!==t.responseStatus){const r={status:t.responseStatus},n={rxSize:t.transferSize,duration:Math.floor(t.duration),cbTime:0};pe(r,t.name),this.handler("xhr",[r,n,t.startTime,t.responseEnd,e[t.initiatorType]],void 0,a.K7.ajax)}}))}catch(e){}ne(this.ee),Z(this.ee),function(e,t,r,n){function i(e){var t=this;t.totalCbs=0,t.called=0,t.cbTime=0,t.end=R,t.ended=!1,t.xhrGuids={},t.lastSize=null,t.loadCaptureCalled=!1,t.params=this.params||{},t.metrics=this.metrics||{},e.addEventListener("load",(function(r){T(t,e)}),(0,A.jT)(!1)),p.lR||e.addEventListener("progress",(function(e){t.lastSize=e.loaded}),(0,A.jT)(!1))}function o(e){this.params={method:e[0]},pe(this,e[1]),this.metrics={}}function s(t,r){e.loader_config.xpid&&this.sameOrigin&&r.setRequestHeader("X-NewRelic-ID",e.loader_config.xpid);var i=n.generateTracePayload(this.parsedOrigin);if(i){var o=!1;i.newrelicHeader&&(r.setRequestHeader("newrelic",i.newrelicHeader),o=!0),i.traceContextParentHeader&&(r.setRequestHeader("traceparent",i.traceContextParentHeader),i.traceContextStateHeader&&r.setRequestHeader("tracestate",i.traceContextStateHeader),o=!0),o&&(this.dt=i)}}function c(e,r){var n=this.metrics,i=e[0],o=this;if(n&&i){var a=G(i);a&&(n.txSize=a)}this.startTime=(0,S.t)(),this.body=i,this.listener=function(e){try{"abort"!==e.type||o.loadCaptureCalled||(o.params.aborted=!0),("load"!==e.type||o.called===o.totalCbs&&(o.onloadCalled||"function"!=typeof r.onload)&&"function"==typeof o.end)&&o.end(r)}catch(e){try{t.emit("internal-error",[e])}catch(e){}}};for(var s=0;s<de;s++)r.addEventListener(ue[s],this.listener,(0,A.jT)(!1))}function u(e,t,r){this.cbTime+=e,t?this.onloadCalled=!0:this.called+=1,this.called!==this.totalCbs||!this.onloadCalled&&"function"==typeof r.onload||"function"!=typeof this.end||this.end(r)}function d(e,t){var r=""+V(e)+!!t;this.xhrGuids&&!this.xhrGuids[r]&&(this.xhrGuids[r]=!0,this.totalCbs+=1)}function l(e,t){var r=""+V(e)+!!t;this.xhrGuids&&this.xhrGuids[r]&&(delete this.xhrGuids[r],this.totalCbs-=1)}function f(){this.endTime=(0,S.t)()}function h(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-added",[e[1],e[2]],r)}function g(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-removed",[e[1],e[2]],r)}function m(e,t,r){t instanceof fe&&("onload"===r&&(this.onload=!0),("load"===(e[0]&&e[0].type)||this.onload)&&(this.xhrCbStart=(0,S.t)()))}function v(e,r){this.xhrCbStart&&t.emit("xhr-cb-time",[(0,S.t)()-this.xhrCbStart,this.onload,r],r)}function b(e){var t,r=e[1]||{};if("string"==typeof e[0]?0===(t=e[0]).length&&p.RI&&(t=""+p.gm.location.href):e[0]&&e[0].url?t=e[0].url:p.gm?.URL&&e[0]&&e[0]instanceof URL?t=e[0].href:"function"==typeof e[0].toString&&(t=e[0].toString()),"string"==typeof t&&0!==t.length){t&&(this.parsedOrigin=(0,ie.D)(t),this.sameOrigin=this.parsedOrigin.sameOrigin);var i=n.generateTracePayload(this.parsedOrigin);if(i&&(i.newrelicHeader||i.traceContextParentHeader))if(e[0]&&e[0].headers)s(e[0].headers,i)&&(this.dt=i);else{var o={};for(var a in r)o[a]=r[a];o.headers=new Headers(r.headers||{}),s(o.headers,i)&&(this.dt=i),e.length>1?e[1]=o:e.push(o)}}function s(e,t){var r=!1;return t.newrelicHeader&&(e.set("newrelic",t.newrelicHeader),r=!0),t.traceContextParentHeader&&(e.set("traceparent",t.traceContextParentHeader),t.traceContextStateHeader&&e.set("tracestate",t.traceContextStateHeader),r=!0),r}}function y(e,t){this.params={},this.metrics={},this.startTime=(0,S.t)(),this.dt=t,e.length>=1&&(this.target=e[0]),e.length>=2&&(this.opts=e[1]);var r,n=this.opts||{},i=this.target;"string"==typeof i?r=i:"object"==typeof i&&i instanceof le?r=i.url:p.gm?.URL&&"object"==typeof i&&i instanceof URL&&(r=i.href),pe(this,r);var o=(""+(i&&i instanceof le&&i.method||n.method||"GET")).toUpperCase();this.params.method=o,this.body=n.body,this.txSize=G(n.body)||0}function w(e,t){if(this.endTime=(0,S.t)(),this.params||(this.params={}),(0,ce.iW)(this.params))return;let n;this.params.status=t?t.status:0,"string"==typeof this.rxSize&&this.rxSize.length>0&&(n=+this.rxSize);const i={txSize:this.txSize,rxSize:n,duration:(0,S.t)()-this.startTime};r("xhr",[this.params,i,this.startTime,this.endTime,"fetch"],this,a.K7.ajax)}function R(e){const t=this.params,n=this.metrics;if(!this.ended){this.ended=!0;for(let t=0;t<de;t++)e.removeEventListener(ue[t],this.listener,!1);t.aborted||(0,ce.iW)(t)||(n.duration=(0,S.t)()-this.startTime,this.loadCazptureCalled||4!==e.readyState?null==t.status&&(t.status=0):T(this,e),n.cbTime=this.cbTime,r("xhr",[t,n,this.startTime,this.endTime,"xhr"],this,a.K7.ajax))}}function T(e,r){e.params.status=r.status;var n=function(e,t){var r=e.responseType;return"json"===r&&null!==t?t:"arraybuffer"===r||"blob"===r||"json"===r?G(e.response):"text"===r||""===r||void 0===r?G(e.responseText):void 0}(r,e.lastSize);if(n&&(e.metrics.rxSize=n),e.sameOrigin){var i=r.getResponseHeader("X-NewRelic-App-Data");i&&((0,x.p)(O.rs,["Ajax/CrossApplicationTracing/Header/Seen"],void 0,a.K7.metrics,t),e.params.cat=i.split(", ").pop())}e.loadCaptureCalled=!0}t.on("new-xhr",i),t.on("open-xhr-start",o),t.on("open-xhr-end",s),t.on("send-xhr-start",c),t.on("xhr-cb-time",u),t.on("xhr-load-added",d),t.on("xhr-load-removed",l),t.on("xhr-resolved",f),t.on("addEventListener-end",h),t.on("removeEventListener-end",g),t.on("fn-end",v),t.on("fetch-before-start",b),t.on("fetch-start",y),t.on("fn-start",m),t.on("fetch-done",w)}(e,this.ee,this.handler,this.dt),this.importAggregator(e)}}function pe(e,t){var r=(0,ie.D)(t),n=e.params||e;n.hostname=r.hostname,n.port=r.port,n.protocol=r.protocol,n.host=r.hostname+":"+r.port,n.pathname=r.pathname,e.parsedOrigin=r,e.sameOrigin=r.sameOrigin}const ge={},me=["pushState","replaceState"];function ve(e){const t=function(e){return(e||B.ee).get("history")}(e);return!p.RI||ge[t.debugId]++||(ge[t.debugId]=1,(0,W.YM)(t).inPlace(window.history,me,"-")),t}var be=i(3738);const{He:ye,bD:we,d3:Re,Kp:xe,TZ:Te,Lc:Ae,uP:Ee,Rz:Se}=be;class Ne extends b{static featureName=Te;constructor(e,t=!0){super(e,Te,t);if(!(0,m.V)(this.agentIdentifier))return void this.deregisterDrain();const r=this.ee;let n;ve(r),this.eventsEE=(0,F.u)(r),this.eventsEE.on(Ee,(function(e,t){this.bstStart=(0,S.t)()})),this.eventsEE.on(Ae,(function(e,t){(0,x.p)("bst",[e[0],t,this.bstStart,(0,S.t)()],void 0,a.K7.sessionTrace,r)})),r.on(Se+Re,(function(e){this.time=(0,S.t)(),this.startPath=location.pathname+location.hash})),r.on(Se+xe,(function(e){(0,x.p)("bstHist",[location.pathname+location.hash,this.startPath,this.time],void 0,a.K7.sessionTrace,r)}));try{n=new PerformanceObserver((e=>{const t=e.getEntries();(0,x.p)(ye,[t],void 0,a.K7.sessionTrace,r)})),n.observe({type:we,buffered:!0})}catch(e){}this.importAggregator(e,{resourceObserver:n})}}var Oe=i(2614);class _e extends b{static featureName=t.TZ;#i;#o;constructor(e,r=!0){let n;super(e,t.TZ,r),this.replayRunning=!1,this.#o=e;try{n=JSON.parse(localStorage.getItem("".concat(Oe.H3,"_").concat(Oe.uh)))}catch(e){}(0,g.SR)(e.agentIdentifier)&&this.ee.on(t.G4.RECORD,(()=>this.#a())),this.#s(n)?(this.#i=n?.sessionReplayMode,this.#c()):this.importAggregator(e),this.ee.on("err",(e=>{this.replayRunning&&(this.errorNoticed=!0,(0,x.p)(t.G4.ERROR_DURING_REPLAY,[e],void 0,this.featureName,this.ee))})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.replayRunning=e}))}#s(e){return e&&(e.sessionReplayMode===Oe.g.FULL||e.sessionReplayMode===Oe.g.ERROR)||(0,g.Aw)(this.agentIdentifier)}#u=!1;async#c(e){if(!this.#u){this.#u=!0;try{const{Recorder:t}=await Promise.all([i.e(478),i.e(249)]).then(i.bind(i,8589));this.recorder??=new t({mode:this.#i,agentIdentifier:this.agentIdentifier,trigger:e,ee:this.ee}),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording}catch(e){}this.importAggregator(this.#o,{recorder:this.recorder,errorNoticed:this.errorNoticed})}}#a(){this.featAggregate?this.featAggregate.mode!==Oe.g.FULL&&this.featAggregate.initializeRecording(Oe.g.FULL,!0):(this.#i=Oe.g.FULL,this.#c(t.Qb.API),this.recorder&&this.recorder.parent.mode!==Oe.g.FULL&&(this.recorder.parent.mode=Oe.g.FULL,this.recorder.stopRecording(),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording))}}var Ie=i(3962);class je extends b{static featureName=Ie.TZ;constructor(e,t=!0){if(super(e,Ie.TZ,t),!p.RI||!(0,R.dV)().o.MO)return;const r=ve(this.ee);Ie.tC.forEach((e=>{(0,A.sp)(e,(e=>{a(e)}),!0)}));const n=()=>(0,x.p)("newURL",[(0,S.t)(),""+window.location],void 0,this.featureName,this.ee);r.on("pushState-end",n),r.on("replaceState-end",n);try{this.removeOnAbort=new AbortController}catch(e){}(0,A.sp)("popstate",(e=>(0,x.p)("newURL",[e.timeStamp,""+window.location],void 0,this.featureName,this.ee)),!0,this.removeOnAbort?.signal);let i=!1;const o=new((0,R.dV)().o.MO)(((e,t)=>{i||(i=!0,requestAnimationFrame((()=>{(0,x.p)("newDom",[(0,S.t)()],void 0,this.featureName,this.ee),i=!1})))})),a=(0,v.s)((e=>{(0,x.p)("newUIEvent",[e],void 0,this.featureName,this.ee),o.observe(document.body,{attributes:!0,childList:!0,subtree:!0,characterData:!0})}),100,{leading:!0});this.abortHandler=function(){this.removeOnAbort?.abort(),o.disconnect(),this.abortHandler=void 0},this.importAggregator(e,{domObserver:o})}}var Pe=i(7378);const Ce={},ke=["appendChild","insertBefore","replaceChild"];function Le(e){const t=function(e){return(e||B.ee).get("jsonp")}(e);if(!p.RI||Ce[t.debugId])return t;Ce[t.debugId]=!0;var r=(0,W.YM)(t),n=/[?&](?:callback|cb)=([^&#]+)/,i=/(.*)\.([^.]+)/,o=/^(\w+)(\.|$)(.*)$/;function a(e,t){if(!e)return t;const r=e.match(o),n=r[1];return a(r[3],t[n])}return r.inPlace(Node.prototype,ke,"dom-"),t.on("dom-start",(function(e){!function(e){if(!e||"string"!=typeof e.nodeName||"script"!==e.nodeName.toLowerCase())return;if("function"!=typeof e.addEventListener)return;var o=(s=e.src,c=s.match(n),c?c[1]:null);var s,c;if(!o)return;var u=function(e){var t=e.match(i);if(t&&t.length>=3)return{key:t[2],parent:a(t[1],window)};return{key:e,parent:window}}(o);if("function"!=typeof u.parent[u.key])return;var d={};function l(){t.emit("jsonp-end",[],d),e.removeEventListener("load",l,(0,A.jT)(!1)),e.removeEventListener("error",f,(0,A.jT)(!1))}function f(){t.emit("jsonp-error",[],d),t.emit("jsonp-end",[],d),e.removeEventListener("load",l,(0,A.jT)(!1)),e.removeEventListener("error",f,(0,A.jT)(!1))}r.inPlace(u.parent,[u.key],"cb-",d),e.addEventListener("load",l,(0,A.jT)(!1)),e.addEventListener("error",f,(0,A.jT)(!1)),t.emit("new-jsonp",[e.src],d)}(e[0])})),t}const He={};function De(e){const t=function(e){return(e||B.ee).get("promise")}(e);if(He[t.debugId])return t;He[t.debugId]=!0;var r=t.context,n=(0,W.YM)(t),i=p.gm.Promise;return i&&function(){function e(r){var o=t.context(),a=n(r,"executor-",o,null,!1);const s=Reflect.construct(i,[a],e);return t.context(s).getCtx=function(){return o},s}p.gm.Promise=e,Object.defineProperty(e,"name",{value:"Promise"}),e.toString=function(){return i.toString()},Object.setPrototypeOf(e,i),["all","race"].forEach((function(r){const n=i[r];e[r]=function(e){let i=!1;[...e||[]].forEach((e=>{this.resolve(e).then(a("all"===r),a(!1))}));const o=n.apply(this,arguments);return o;function a(e){return function(){t.emit("propagate",[null,!i],o,!1,!1),i=i||!e}}}})),["resolve","reject"].forEach((function(r){const n=i[r];e[r]=function(e){const r=n.apply(this,arguments);return e!==r&&t.emit("propagate",[e,!0],r,!1,!1),r}})),e.prototype=i.prototype;const o=i.prototype.then;i.prototype.then=function(...e){var i=this,a=r(i);a.promise=i,e[0]=n(e[0],"cb-",a,null,!1),e[1]=n(e[1],"cb-",a,null,!1);const s=o.apply(this,e);return a.nextPromise=s,t.emit("propagate",[i,!0],s,!1,!1),s},i.prototype.then[W.Jt]=o,t.on("executor-start",(function(e){e[0]=n(e[0],"resolve-",this,null,!1),e[1]=n(e[1],"resolve-",this,null,!1)})),t.on("executor-err",(function(e,t,r){e[1](r)})),t.on("cb-end",(function(e,r,n){t.emit("propagate",[n,!0],this.nextPromise,!1,!1)})),t.on("propagate",(function(e,r,n){this.getCtx&&!r||(this.getCtx=function(){if(e instanceof Promise)var r=t.context(e);return r&&r.getCtx?r.getCtx():this})}))}(),t}const Me={},Ke="setTimeout",Ue="setInterval",Ve="clearTimeout",Ge="-start",Fe=[Ke,"setImmediate",Ue,Ve,"clearImmediate"];function Be(e){const t=function(e){return(e||B.ee).get("timer")}(e);if(Me[t.debugId]++)return t;Me[t.debugId]=1;var r=(0,W.YM)(t);return r.inPlace(p.gm,Fe.slice(0,2),Ke+"-"),r.inPlace(p.gm,Fe.slice(2,3),Ue+"-"),r.inPlace(p.gm,Fe.slice(3),Ve+"-"),t.on(Ue+Ge,(function(e,t,n){e[0]=r(e[0],"fn-",null,n)})),t.on(Ke+Ge,(function(e,t,n){this.method=n,this.timerDuration=isNaN(e[1])?0:+e[1],e[0]=r(e[0],"fn-",this,n)})),t}const We={};function ze(e){const t=function(e){return(e||B.ee).get("mutation")}(e);if(!p.RI||We[t.debugId])return t;We[t.debugId]=!0;var r=(0,W.YM)(t),n=p.gm.MutationObserver;return n&&(window.MutationObserver=function(e){return this instanceof n?new n(r(e,"fn-")):n.apply(this,arguments)},MutationObserver.prototype=n.prototype),t}const{TZ:qe,d3:Ze,Kp:Ye,$p:Xe,wW:Je,e5:Qe,tH:$e,uP:et,rw:tt,Lc:rt}=Pe;class nt extends b{static featureName=qe;constructor(e,t=!0){if(super(e,qe,t),!p.RI)return;try{this.removeOnAbort=new AbortController}catch(e){}let r,n=0;const i=this.ee.get("tracer"),o=Le(this.ee),a=De(this.ee),s=Be(this.ee),c=Z(this.ee),u=this.ee.get("events"),d=ne(this.ee),l=ve(this.ee),f=ze(this.ee);function h(e,t){l.emit("newURL",[""+window.location,t])}function g(){n++,r=window.location.hash,this[et]=(0,S.t)()}function m(){n--,window.location.hash!==r&&h(0,!0);var e=(0,S.t)();this[Qe]=~~this[Qe]+e-this[et],this[rt]=e}function v(e,t){e.on(t,(function(){this[t]=(0,S.t)()}))}this.ee.on(et,g),a.on(tt,g),o.on(tt,g),this.ee.on(rt,m),a.on(Je,m),o.on(Je,m),this.ee.on("fn-err",((...t)=>{t[2]?.__newrelic?.[e.agentIdentifier]||(0,x.p)("function-err",[...t],void 0,this.featureName,this.ee)})),this.ee.buffer([et,rt,"xhr-resolved"],this.featureName),u.buffer([et],this.featureName),s.buffer(["setTimeout"+Ye,"clearTimeout"+Ze,et],this.featureName),c.buffer([et,"new-xhr","send-xhr"+Ze],this.featureName),d.buffer([$e+Ze,$e+"-done",$e+Xe+Ze,$e+Xe+Ye],this.featureName),l.buffer(["newURL"],this.featureName),f.buffer([et],this.featureName),a.buffer(["propagate",tt,Je,"executor-err","resolve"+Ze],this.featureName),i.buffer([et,"no-"+et],this.featureName),o.buffer(["new-jsonp","cb-start","jsonp-error","jsonp-end"],this.featureName),v(d,$e+Ze),v(d,$e+"-done"),v(o,"new-jsonp"),v(o,"jsonp-end"),v(o,"cb-start"),l.on("pushState-end",h),l.on("replaceState-end",h),window.addEventListener("hashchange",h,(0,A.jT)(!0,this.removeOnAbort?.signal)),window.addEventListener("load",h,(0,A.jT)(!0,this.removeOnAbort?.signal)),window.addEventListener("popstate",(function(){h(0,n>1)}),(0,A.jT)(!0,this.removeOnAbort?.signal)),this.abortHandler=this.#n,this.importAggregator(e)}#n(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var it=i(3333);class ot extends b{static featureName=it.TZ;constructor(e,t=!0){super(e,it.TZ,t);const r=[e.init.page_action.enabled,e.init.performance.capture_marks,e.init.performance.capture_measures,e.init.user_actions.enabled];p.RI&&e.init.user_actions.enabled&&(it.Zp.forEach((e=>(0,A.sp)(e,(e=>(0,x.p)("ua",[e],void 0,this.featureName,this.ee)),!0))),it.qN.forEach((e=>(0,A.sp)(e,(e=>(0,x.p)("ua",[e],void 0,this.featureName,this.ee)))))),r.some((e=>e))?this.importAggregator(e):this.deregisterDrain()}}var at=i(993),st=i(3785);class ct extends b{static featureName=at.TZ;constructor(e,t=!0){super(e,at.TZ,t);const r=this.ee;this.ee.on("wrap-logger-end",(function([e]){const{level:t,customAttributes:n}=this;(0,st.R)(r,e,n,t)})),this.importAggregator(e)}}new class extends o{constructor(t,r){super(r),p.gm?(this.features={},(0,R.bQ)(this.agentIdentifier,this),this.desiredFeatures=new Set(t.features||[]),this.desiredFeatures.add(w),this.runSoftNavOverSpa=[...this.desiredFeatures].some((e=>e.featureName===a.K7.softNav)),(0,d.j)(this,t,t.loaderType||"agent"),this.run()):(0,e.R)(21)}get config(){return{info:this.info,init:this.init,loader_config:this.loader_config,runtime:this.runtime}}run(){try{const t=u(this.agentIdentifier),r=[...this.desiredFeatures];r.sort(((e,t)=>a.P3[e.featureName]-a.P3[t.featureName])),r.forEach((r=>{if(!t[r.featureName]&&r.featureName!==a.K7.pageViewEvent)return;if(this.runSoftNavOverSpa&&r.featureName===a.K7.spa)return;if(!this.runSoftNavOverSpa&&r.featureName===a.K7.softNav)return;const n=function(e){switch(e){case a.K7.ajax:return[a.K7.jserrors];case a.K7.sessionTrace:return[a.K7.ajax,a.K7.pageViewEvent];case a.K7.sessionReplay:return[a.K7.sessionTrace];case a.K7.pageViewTiming:return[a.K7.pageViewEvent];default:return[]}}(r.featureName).filter((e=>!(e in this.features)));n.length>0&&(0,e.R)(36,{targetFeature:r.featureName,missingDependencies:n}),this.features[r.featureName]=new r(this)}))}catch(t){(0,e.R)(22,t);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,R.Zm)();delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.features,delete this.sharedAggregator;return r.ee.get(this.agentIdentifier).abort(),!1}}}({features:[he,w,N,Ne,_e,_,D,ot,ct,je,nt],loaderType:"spa"})})()})();</script> <link rel="shortcut icon" href="https://acdbio.com/sites/default/files/favicon_0.ico" type="image/vnd.microsoft.icon" /> <meta name="robots" content="follow, index" /> <link rel="canonical" href="https://acdbio.com/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay" />  <title>Search results | In Situ Hybridization, RNA-ISH | ACDBio</title> <meta name="google-site-verification" content="cCacrM1YM776lQJj5HYsJww24W9_bdfp20b8ksJDjS8" /> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link rel="alternate" href="https://acdbio.com/" hreflang="en-us" /> <link type="text/css" rel="stylesheet" href="https://acdbio.com/sites/default/files/css/css_uLzr_DJ4usWt92pdsOz-ZaxtEiQkKMbYce4_DVHtJwc.css" media="all" />  <script type="text/javascript" src="https://acdbio.com/sites/default/files/js/js_QkA6vcnQyz9tY0W0F5HgpoFJ9g5nyPJwGskEOhqYO68.js"></script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript" src="https://acdbio.com/sites/default/files/js/js_78sG-9EVuWusjJGUtzJvKfye9fgUDUBkpWEc69J9NwA.js"></script> <script type="text/javascript"> <![CDATA[//><!]]> </script>  <script type="text/javascript">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= '//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-P9Z9VN');</script>  <script>(window.BOOMR_mq=window.BOOMR_mq||[]).push(["addVar",{"rua.upush":"false","rua.cpush":"false","rua.upre":"false","rua.cpre":"false","rua.uprl":"false","rua.cprl":"false","rua.cprf":"false","rua.trans":"","rua.cook":"false","rua.ims":"false","rua.ufprl":"false","rua.cfprl":"false","rua.isuxp":"false","rua.texp":"norulematch","rua.ceh":"false","rua.ueh":"false","rua.ieh.st":"0"}]);</script> <script>!function(e){var n="https://s.go-mpulse.net/boomerang/";if("False"=="True")e.BOOMR_config=e.BOOMR_config||{},e.BOOMR_config.PageParams=e.BOOMR_config.PageParams||{},e.BOOMR_config.PageParams.pci=!0,n="https://s2.go-mpulse.net/boomerang/";if(window.BOOMR_API_key="QEZ55-P527E-LVKSE-MNC9N-NHZCR",function(){function e(){if(!o){var e=document.createElement("script");e.id="boomr-scr-as",e.src=window.BOOMR.url,e.async=!0,i.parentNode.appendChild(e),o=!0}}function t(e){o=!0;var n,t,a,r,d=document,O=window;if(window.BOOMR.snippetMethod=e?"if":"i",t=function(e,n){var t=d.createElement("script");t.id=n||"boomr-if-as",t.src=window.BOOMR.url,BOOMR_lstart=(new Date).getTime(),e=e||d.body,e.appendChild(t)},!window.addEventListener&&window.attachEvent&&navigator.userAgent.match(/MSIE [67]\./))return window.BOOMR.snippetMethod="s",void t(i.parentNode,"boomr-async");a=document.createElement("IFRAME"),a.src="about:blank",a.title="",a.role="presentation",a.loading="eager",r=(a.frameElement||a).style,r.width=0,r.height=0,r.border=0,r.display="none",i.parentNode.appendChild(a);try{O=a.contentWindow,d=O.document.open()}catch(_){n=document.domain,a.src="javascript:var d=document.open();d.domain='"+n+"';void(0);",O=a.contentWindow,d=O.document.open()}if(n)d._boomrl=function(){this.domain=n,t()},d.write("<bo"+"dy onload='document._boomrl();'>");else if(O._boomrl=function(){t()},O.addEventListener)O.addEventListener("load",O._boomrl,!1);else if(O.attachEvent)O.attachEvent("onload",O._boomrl);d.close()}function a(e){window.BOOMR_onload=e&&e.timeStamp||(new Date).getTime()}if(!window.BOOMR||!window.BOOMR.version&&!window.BOOMR.snippetExecuted){window.BOOMR=window.BOOMR||{},window.BOOMR.snippetStart=(new Date).getTime(),window.BOOMR.snippetExecuted=!0,window.BOOMR.snippetVersion=12,window.BOOMR.url=n+"QEZ55-P527E-LVKSE-MNC9N-NHZCR";var i=document.currentScript||document.getElementsByTagName("script")[0],o=!1,r=document.createElement("link");if(r.relList&&"function"==typeof r.relList.supports&&r.relList.supports("preload")&&"as"in r)window.BOOMR.snippetMethod="p",r.href=window.BOOMR.url,r.rel="preload",r.as="script",r.addEventListener("load",e),r.addEventListener("error",function(){t(!0)}),setTimeout(function(){if(!o)t(!0)},3e3),BOOMR_lstart=(new Date).getTime(),i.parentNode.appendChild(r);else t(!1);if(window.addEventListener)window.addEventListener("load",a,!1);else if(window.attachEvent)window.attachEvent("onload",a)}}(),"".length>0)if(e&&"performance"in e&&e.performance&&"function"==typeof e.performance.setResourceTimingBufferSize)e.performance.setResourceTimingBufferSize();!function(){if(BOOMR=e.BOOMR||{},BOOMR.plugins=BOOMR.plugins||{},!BOOMR.plugins.AK){var n=""=="true"?1:0,t="",a="bdpnbeqxbwwjoz2b4oha-f-6d28d96ef-clientnsv4-s.akamaihd.net",i="false"=="true"?2:1,o={"ak.v":"39","ak.cp":"1653242","ak.ai":parseInt("1065117",10),"ak.ol":"0","ak.cr":216,"ak.ipv":4,"ak.proto":"http/1.1","ak.rid":"8704471c","ak.r":41489,"ak.a2":n,"ak.m":"","ak.n":"essl","ak.bpcip":"8.222.208.0","ak.cport":51318,"ak.gh":"23.220.106.146","ak.quicv":"","ak.tlsv":"tls1.2","ak.0rtt":"","ak.0rtt.ed":"","ak.csrc":"-","ak.acc":"reno","ak.t":"1732371342","ak.ak":"hOBiQwZUYzCg5VSAfCLimQ==M9ais6NZaTgojuNravxpuWygBZMV+oljiI9J2+4TGmtyN+U4XuAsHYgowbFtwD54b0AkkAiWNOSoFI+xgKj4XvJ7bEVKVODlqWQ/8xzUi+4xqfA0ktudRX3XP+XJ7Z2ZBD5BFJg2ljVEXbIJVz5P0LnIrQE6Zu+xWERsX61Q7mIqgQqL7F6796mKhnAJw/kTKxOQMkxgWu4z/hhA6B2cAQrUiszQzi1Sw0AdlXd3cAAAAlxHshry8NTkeOIR1Kvjtpfg/brmEYgAPHB/P7VWVb77NkYD1pG9zjqDkXdSAsSmyguET1dJXESHtw2iLb4bZfPG5QSJj+xhLRz2wDmE7OHSbAW9TosfmWvRBhwJTdgOLiF3fxpDIp2bbCii+tcwdATAhxNijnXDspSXJQUvLst7AsZ405yVMnF9xqWF75s=","ak.pv":"3","ak.dpoabenc":"","ak.tf":i};if(""!==t)o["ak.ruds"]=t;var r={i:!1,av:function(n){var t="http.initiator";if(n&&(!n[t]||"spa_hard"===n[t]))o["ak.feo"]=void 0!==e.aFeoApplied?1:0,BOOMR.addVar(o)},rv:function(){var e=["ak.bpcip","ak.cport","ak.cr","ak.csrc","ak.gh","ak.ipv","ak.m","ak.n","ak.ol","ak.proto","ak.quicv","ak.tlsv","ak.0rtt","ak.0rtt.ed","ak.r","ak.acc","ak.t","ak.tf"];BOOMR.removeVar(e)}};BOOMR.plugins.AK={akVars:o,akDNSPreFetchDomain:a,init:function(){if(!r.i){var e=BOOMR.subscribe;e("before_beacon",r.av,null,null),e("onbeacon",r.rv,null,null),r.i=!0}return this},is_complete:function(){return!0}}}}()}(window);</script></head> <body class="html not-front not-logged-in one-sidebar sidebar-first page-science page-science-scientific-resources page-science-scientific-resources-publications page-science-scientific-resources-publications-multiplex page-science-scientific-resources-publications-multiplex-product page-science-scientific-resources-publications-multiplex-product-rnascopesup® page-science-scientific-resources-publications-multiplex-product-rnascopesup®-sup-multiplex-fluorescent-assay page-science-scientific-resources-publications-multiplex-product-rnascopesup®-sup-multiplex-fluorescent-assay-product page-science-scientific-resources-publications-multiplex-product-rnascopesup®-sup-multiplex-fluorescent-assay-product-rnascopesup® page-science-scientific-resources-publications-multiplex-product-rnascopesup®-sup-multiplex-fluorescent-assay-product-rnascopesup®-sup-ls-multiplex-assay " onload="DrawCaptcha();">  <noscript><iframe src="//www.googletagmanager.com/ns.html?id=GTM-P9Z9VN" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>  <link rel="stylesheet" type="text/css" href="/sites/all/themes/acd/css/style-search.css?q=20241123 " /><link rel="stylesheet" type="text/css" href="/sites/all/themes/acd/css/custom.css?q=20241123 " /><link rel="stylesheet" type="text/css" href="/sites/all/themes/acd/css/style-product.css?q=20241123 " /> <script type="text/javascript" src="/sites/all/themes/acd/js/readmore.js?q=20241123 "></script> <script type="text/javascript"> jQuery(document).ready(function($) { $('.publication-abstract-read').readmore({ speed: 500, moreLink: '<a href="#" class="abstract">Read Abstract</a>', lessLink: '<a href="#" class="abstract less">Read Abstract</a>' }); $('html, body').animate({ scrollTop: $(".search-publications-container").offset().top }, 1000); // $('.form-item-field-research-area-tid,.form-item-field-species-common-tid').readmore({ // speed: 500, // moreLink: '<a href="#" class="show-more">Show more</a>', // lessLink: '<a href="#" class="show-more">Show fewer</a>' // }); // $(document).ajaxComplete(function(event, xhr, settings) { // $('.abstract-read').readmore({ // speed: 500, // moreLink: '<a href="#" class="abstract">Read Abstract</a>', // lessLink: '<a href="#" class="abstract less">Read Abstract</a>' // }); // $('.form-item-field-research-area-tid,.form-item-field-species-common-tid').readmore({ // speed: 500, // moreLink: '<a href="#" class="show-more">Show more</a>', // lessLink: '<a href="#" class="show-more">Show fewer</a>' // }); // }); }); </script> <div class="container science-template pub-search-page"> <script type="text/javascript"> jQuery(document).ready(function($) { var windowsize = $(window).width(); var bottom = document.getElementById('anchorid').offsetTop; if(windowsize < 767){ var childmenu = '<ul style="display: none;">' + '<li><a title="" href="/store/checkout">Checkout</a></li>' + '<li><a title="" href="/store/customer/account/create">Register</a></li>'+ '<li><a title="" href="/store/customer/account/login">Log In</a></li>'+ '</ul>'+ '<a style="font-size: 18px" href="#" class="mean-expand own-account-menu-expand">+</a>'; $('.mean-nav ul li:nth-of-type(6)').append(childmenu); } $(window).resize(function() { windowsize = $(window).width(); if(windowsize < 767){ var childmenu = '<ul style="display: none;">' + '<li><a title="" href="/store/checkout">Checkout</a></li>' + '<li><a title="" href="/store/customer/account/create">Register</a></li>'+ '<li><a title="" href="/store/customer/account/login">Log In</a></li>'+ '</ul>'+ '<a style="font-size: 18px" href="#" class="mean-expand own-account-menu-expand">+</a>'; $('.mean-nav ul li:nth-of-type(6)').append(childmenu); } }); $(document).on("click",".own-account-menu-expand",function(e){ e.preventDefault(); if ($(this).hasClass("mean-clicked")) { $(this).prev('ul').slideUp(300, function(){}); } else { $(this).prev('ul').slideDown(300, function(){}); } $(this).toggleClass("mean-clicked"); $(this).parent().toggleClass('active'); }); $(window).resize(function(event) { if ($(this).scrollTop() > bottom){ $('.region.region-header').addClass('issticky'); $('.meanmenu-reveal,.mean-bar').addClass('issticky'); } else{ $('.region.region-header').removeClass('issticky'); $('.meanmenu-reveal,.mean-bar').removeClass('issticky'); } }); $(window).scroll(function(){ if(windowsize > 767) { if ($(this).scrollTop() > bottom){ $('.region.region-header').addClass('issticky'); $('.meanmenu-reveal,.mean-bar').addClass('issticky'); if(windowsize < 767){ $('.region.region-header .newlogo img').attr("src","/sites/all/themes/acd/img/mob-logo-inner.png"); }else{ $('.region.region-header .newlogo img').attr("src","/sites/all/themes/acd/img/logo-2.png"); } } else{ $('.region.region-header').removeClass('issticky'); $('.meanmenu-reveal,.mean-bar').removeClass('issticky'); $('.region.region-header .newlogo img').attr("src","/sites/all/themes/acd/img/logo-2.png"); } } if(windowsize < 768) { if ($(this).scrollTop() > bottom){ $('.region.region-header').addClass('issticky'); $('.region.region-header .newlogo img').attr("src","/sites/all/themes/acd/img/logo-2.png"); } else { $('.region.region-header').removeClass('issticky'); $('.region.region-header .newlogo img').attr("src","/sites/all/themes/acd/img/logo-2.png"); } } }); }); </script> <div class="region region-header clearfix"><div class="search_popup"></div> <header class="header"><div class="menu_popup"></div><div class="header-top container-fluid"><div class="row"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 panel__bar"><div class="top-help-links"> <a class="top-help-contact" href="#help-ticket-id"><span>Contact Us / Request a Quote</span></a> <a href="/documents/product-documents"><span>Download Manuals</span></a></div></div></div></div><div class="container"><div class="row nav-menu" id="anchorid"><div class="col-lg-1 col-md-1 col-sm-1 col-xs-12 header-logo"> <a href="/" class="newlogo"> <img class="large767" alt="Advanced Cell Diagnostics" src="/sites/all/themes/acd/img/logo-2.png"/> <img class="large" alt="Advanced Cell Diagnostics" src="/sites/all/themes/acd/img/logo-2.png"/> </a></div><div class="row"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 search-bar"><form action="/science/scientific-resources/publications/multiplex/product/rnascope<sup><sup>®</sup></sup>-multiplex-fluorescent-assay/product/rnascope<sup><sup>®</sup></sup>-ls-multiplex-assay" method="post" id="search-block-form" accept-charset="UTF-8"><div><div class="container-inline"><h2 class="element-invisible">Search form</h2><div class="form-item form-type-textfield form-item-search-block-form"> <label class="element-invisible" for="edit-search-block-form--2">Search </label> <input title="Enter the terms you wish to search for." type="text" id="edit-search-block-form--2" name="search_block_form" value="" size="15" maxlength="128" class="form-text" /></div><div class="form-item form-type-checkboxes form-item-search-filter"> <label for="edit-search-filter"><div class="search-txt">Search</div><div class="arrow"></div> </label><div id="edit-search-filter" class="form-checkboxes"><div class="form-item form-type-checkbox form-item-search-filter-120059"> <input type="checkbox" id="edit-search-filter-120059" name="search_filter[120059]" value="120059" class="form-checkbox" /> <label class="option" for="edit-search-filter-120059">Controls & Probes </label></div><div class="form-item form-type-checkbox form-item-search-filter-9"> <input type="checkbox" id="edit-search-filter-9" name="search_filter[9]" value="9" class="form-checkbox" /> <label class="option" for="edit-search-filter-9">Kits & Accessories </label></div><div class="form-item form-type-checkbox form-item-search-filter-11"> <input type="checkbox" id="edit-search-filter-11" name="search_filter[11]" value="11" class="form-checkbox" /> <label class="option" for="edit-search-filter-11">Support & Documents </label></div><div class="form-item form-type-checkbox form-item-search-filter-10"> <input type="checkbox" id="edit-search-filter-10" name="search_filter[10]" value="10" class="form-checkbox" /> <label class="option" for="edit-search-filter-10">Science </label></div><div class="form-item form-type-checkbox form-item-search-filter-33958"> <input type="checkbox" id="edit-search-filter-33958" name="search_filter[33958]" value="33958" class="form-checkbox" /> <label class="option" for="edit-search-filter-33958">Image gallery </label></div></div></div><div class="form-actions form-wrapper" id="edit-actions"><input type="submit" id="edit-submit" name="op" value="Search" class="form-submit" /></div><input type="hidden" name="form_build_id" value="form-VJXo1TFOXnkPJx3R3Zhgvtumy5sYNIGMv1SqyxmL1Us" /><input type="hidden" name="form_id" value="search_block_form" /></div></div></form><div class="search-x-close"></div></div></div><div class="top-account-cart"><div class="icon-3 account-menu login-icon"><span>Please sign in</span></div><div class="skip-content" id="header-account"><div class="links"><ul><li><a href="/store/customer/account/login">Log In</a></li><li><a href="/store/customer/account/create">Register</a></li><li><a href="/products/how-to-order">How to Order</a></li><li><a href="/products/new-to-rnascope">What to Buy</a></li></ul></div></div><div class="minicart-header-content" ><div class="cartcontain"><a href="#header-cart" onclick="setLocation('https://acdbio.com/store/checkout/cart/')" class="skip-link skip-cart no-count"> <span class="count">0</span> <span class="label">My Cart</span></a><div id="header-cart" class="block block-cart skip-content"><div id="minicart-error-message" class="minicart-message"></div><div id="minicart-success-message" class="minicart-message"></div><div class="minicart-wrapper"><div class="cart-close"><a class="close skip-link-close" href="#" title="Close">X</a></div><p class="minicartempty empty">You have no items in your shopping cart.</p></div></div></div></div><div class="clear"></div></div><div class="col-lg-10 col-md-10 col-sm-10 col-xs-12 header-menus" id="responsive-mobile-menu"><div class="mob-menu visible-xs">Menu</div><div class="menu-close">X</div><ul class="new-menu"><li class="level0 products"> <a href="/products" class="level0">Products</a> <span class="level0 visible-xs">+</span><div class="menu-content"><div class="container"><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="row"><div class="col-lg-12 menu-col"><div class="sec-title">RNAscope™/BaseScope™/ miRNAscope™</div> <span class="sectitle-span">+</span><ul><li><a href="/rnascope%C2%AE-and-basescope%E2%84%A2-assays">Assay Selection Guide</a></li></ul></div></div><div class="row"><div class="col-lg-12 menu-col"><div class="sec-title">Target Probes</div> <span class="sectitle-span">+</span><ul><li><a href="/all-about-probes">All About Probes</a></li><li><a href="/catalog-probes">Catalog Probes</a></li><li><a href="/probe-sets">Probe Sets</a></li><li><a href="/target-probes-made-order">New Probe Request</a></li></ul></div></div></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Manual Assays</div> <span class="sectitle-span">+</span><div class="sub-wrap"><div class="sec-subtitle">RNAscope™ Chromogenic</div><ul><li><a href="/manual-assays-rnascope">Overview</a></li><li><a href="/rnascope%C2%AE-25-hd-assay%E2%80%94brown">RNAscope™ 2.5 HD Assay-Brown</a></li><li><a href="/rnascope%C2%AE-25-hd-assay%E2%80%94red">RNAscope™ 2.5 HD Assay-Red</a></li><li><a href="/rnascope%C2%AE-25-hd-duplex-assay">RNAscope™ 2.5 HD Duplex Assay</a></li></ul><div class="sec-subtitle">RNAscope™ Multiplex Fluorescent</div><ul><li><a href="/rnascope%C2%AE-fluorescent-multiplex-assays">Overview</a></li><li><a href="/rnascope%C2%AE-hiplex-assays">RNAscope™ HiPlex v2 Assay</a></li><li><a href="/rnascope%C2%AE-multiplex-fluorescent-v2-assay">RNAscope™ Multiplex Fluorescent V2</a></li></ul><div class="sec-subtitle">BaseScope™</div><ul><li><a href="/basescope%E2%84%A2-manual-assays">Overview</a></li><li><a href="/basescope%E2%84%A2%C2%A0reagent-kit-red">BaseScope™ Assay Red</a></li><li><a href="/basescope%E2%84%A2-duplex-assay">BaseScope™ Duplex Assay</a></li></ul><div class="sec-subtitle">miRNAscope™</div><ul><li><a href="/mirnascope-assay-red-overview">Overview</a></li><li><a href="/mirnascope-hd-assay-red">miRNAscope™ Assay red</a></li><li><a href="/rnascope%E2%84%A2-plus-smrna-rna-assay">RNAscope™ Plus smRNA-RNA Assay</a></li></ul><div class="sec-subtitle">DNAscope™</div><ul><li><a href="/dnascope-assay-overview">Overview</a></li><li><a href="/dnascope-duplex-assay">DNAscope™ Duplex Assay</a></li></ul></div></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Automated Assays</div> <span class="sectitle-span">+</span><div class="sub-wrap"><div class="sec-subtitle">For Lunaphore COMET™</div><ul><li><a href="/rnascope-hiplex-pro-comet">RNAscope™ HiPlex Pro for COMET™</a></li></ul><div class="sec-subtitle">For Leica systems</div><ul><li><a href="/automated-assay-leica">Overview</a></li><li><a href="/rnascope%C2%AE-25-ls-assay-brown">RNAscope™ 2.5 LS Assay-Brown</a></li><li><a href="/rnascope%C2%AE-25-ls-assay-red">RNAscope™ 2.5 LS Assay-Red</a></li><li><a href="/rnascope%C2%AE-25-ls-duplex-assay">RNAscope™ 2.5 LS Duplex Assay</a></li><li><a href="/rnascope-multiomic-ls-fluorescent-assay">RNAscope™ Multiomic LS Assay</a></li><li><a href="/rnascope%C2%AE-ls-multiplex-fluorescent-assay">RNAscope™ 2.5 LS Fluorescent Multiplex Assay</a></li><li><a href="/rnascope-25-lsx-reagent-kit-brown">RNAscope™ 2.5 LSx Reagent Kit-BROWN</a></li><li><a href="/rnascope-25-lsx-reagent-kit-red-0">RNAscope™ 2.5 LSx Reagent Kit-RED</a></li><li><a href="/basescope%E2%84%A2-ls-reagent-kit-%E2%80%93-red-0">BaseScope™ LS Reagent Kit – RED</a></li><li><a href="/mirnascope-ls-reagent-kit-red">miRNAscope LS Reagent Kit Red</a></li><li><a href="/rnascope%E2%84%A2-plus-smrna-rna-ls-assay">RNAscope™ Plus smRNA-RNA LS Assay</a></li></ul><div class="sec-subtitle">Roche DISCOVERY ULTRA system</div><ul><li><a href="/automated-assay-ventana">Overview</a></li><li><a href="/rnascope%C2%AE-vs-universal-hrp-ap">RNAscope™ VS Universal HRP</a></li><li><a href="/rnascope%C2%AE-vs-universal-hrp-ap">RNAscope™ VS Universal AP</a></li><li><a href="/rnascope%C2%AE-vs-duplex-assay">RNAscope™ VS Duplex Assay</a></li><li><a href="/basescope%E2%84%A2-vs-reagent-kit-%E2%80%93-red-0">BaseScope™ VS Reagent Kit – RED</a></li></ul></div></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">RNA-Protein Co-Detection Assay</div> <span class="sectitle-span">+</span><ul><li><a href="/rna-protein-co-detection-imaging-mass-cytometry-and-rnascope-assay">RNAscope HiPlex-IMC™ Co-Detection</a></li><li><a href="/co-detection-of-mrna-and-protein">Integrated Codetection Assay</a></li><li><a href="/science/applications/research-solutions/dual-ish-and-ihc">Sequential RNA Protein Detection</a></li></ul><div class="sec-title">Software</div> <span class="sectitle-span">+</span><ul><li><a href="/software">Overview</a></li><li><a href="/aperio-rna-ish-algorithm">Aperio RNA ISH Algorithm</a></li><li><a href="/halo-image-analysis-platform">HALO<sup>®</sup> image analysis platform</a></li></ul><div class="sec-title">Controls & Accessories</div> <span class="sectitle-span">+</span><div class="sub-wrap"><ul><li><a href="/control-slides-and-control-probes-rnascope">RNAscope™</a></li><li><a href="/control-slides-and-control-probes-basescope%E2%84%A2">BaseScope™</a></li><li><a href="/mirnascope%E2%84%A2-controls-overview-page">miRNAscope™</a></li><li><a href="/hybez-ii-system">Accessories</a></li></ul></div><div class="sec-title">How to Order</div> <span class="sectitle-span">+</span><ul><li><a href="/products/how-to-order">Ordering Instructions</a></li><li><a href="/products/new-to-rnascope">What to Buy</a></li></ul></div></div></div></div></li><li class="level0 assay col-3"> <a href="/pas" class="level0">Services</a> <span class="level0 visible-xs">+</span><div class="menu-content"><div class="container"><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Professional Assay Services</div> <span class="sectitle-span">+</span><ul><li><a href="/pas">Our Services</a></li><li><a href="/new-multiomics-services">Multiomic Services</a></li><li><a href="/biomarker-assay-development">Biomarker Assay Development</a></li><li><a href="/cell-gene-therapy-services">Cell & Gene Therapy Services</a></li><li><a href="/services/CDx-prototype">Clinical Assay Development</a></li><li><a href="/services/acd-tissue-bank">Tissue Bank & Sample Procurement</a></li><li><a href="/services/quantitative-analysis">Image Analysis</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Benefits</div> <span class="sectitle-span">+</span><ul><li><a href="/services/your-benefits-your-success">Your Benefits</a></li><li><a href="/biopharma-partners">Certified Providers</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">How to Order</div> <span class="sectitle-span">+</span><ul><li><a href="/services/how-order">Ordering Process</a></li><li><a href="/contact-services">Contact Services</a></li></ul></div></div></div></div></li><li class="level0 research"> <a href="/science/applications" class="level0">Areas of Research</a> <span class="level0 visible-xs">+</span><div class="menu-content"><div class="container"><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Most Popular</div> <span class="sectitle-span">+</span><ul><li><a href="/science/applications/research-areas/covid-19-coronavirus">COVID-19 Coronavirus</a></li><li><a href="/science/applications/research-solutions/single-cell-analysis">Single Cell Analysis</a></li><li><a href="/science/applications/research-areas/whole-mount">Whole-Mount</a></li><li><a href="/science/applications/research-areas/anatomic-pathology-panels">Anatomic Pathology Panels</a></li><li><a href="/science/applications/research-areas/neuroscience">Neuroscience</a></li><li><a href="/science/applications/research-areas/inflammation">Inflammation</a></li><li><a href="/science/applications/research-areas/gene-therapyaav">Gene Therapy/AAV</a></li><li><a href="/science/applications/research-areas/stem-cell">Stem Cell</a></li><li><a href="/science/applications/research-areas/immuno-oncology">Immuno-oncology</a></li><li><a href="/science/applications/research-areas/rnascope%C2%AE-technology-liver-research">Liver Research</a></li><li><a href="/science/applications/research-areas/rnascope%C2%AE-technology-cardiovascular-skeletal-muscle-research">Cardiovascular & Skeletal Muscle Research</a></li></ul></div><div class="col-lg-2 col-md-2 col-sm-2 col-xs-12 menu-col"><div class="sec-title">Cell & Gene Therapy</div> <span class="sectitle-span">+</span><ul><li><a href="/science/applications/research-areas/gene-therapy-0">Gene Therapy</a></li><li><a href="/science/applications/research-areas/gene-therapyaav">Gene Therapy/AAV</a></li><li><a href="/science/applications/research-areas/sirnaaso">siRNA/ASO</a></li><li><a href="/science/applications/research-solutions/cell-therapy">Cell Therapy</a></li></ul></div><div class="col-lg-2 col-md-2 col-sm-2 col-xs-12 menu-col"><div class="sec-title"><a href="/science/applications/research-areas/cancer">Cancer</a></div> <span class="sectitle-span">+</span><ul><li><a href="/science/applications/research-areas/breast-cancer">Breast Cancer</a></li><li><a href="/egfrviii">EGFRvIII Splice Variant</a></li><li><a href="/science/applications/disease-areas/hpv-related-cancer">HPV Related Cancer</a></li><li><a href="/science/applications/research-areas/immuno-oncology">Immuno-oncology</a></li><li><a href="/science/applications/research-areas/lung-cancer">Lung Cancer</a></li><li><a href="/science/applications/research-areas/pdx">PDx</a></li><li><a href="/science/applications/research-areas/prostate-cancer-research">Prostate Cancer</a></li><li><a href="/science/applications/research-areas/point-mutation">Point Mutation</a></li><li><a href="/science/applications/research-areas/cdr3-tcr">CDR3 for TCR</a></li></ul></div><div class="col-lg-2 col-md-2 col-sm-2 col-xs-12 menu-col"><div class="row"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 menu-col"><div class="sec-title">Viral</div> <span class="sectitle-span">+</span><ul><li><a href="/science/applications/research-areas/covid-19-coronavirus">COVID-19 Coronavirus</a></li><li><a href="/science/applications/research-areas/hiv-siv">HIV & SIV</a></li><li><a href="/science/applications/research-areas/infectious-diseases">Infectious Disease</a></li><li><a href="/science/applications/disease-areas/zika-virus-research">Zika Virus</a></li></ul></div></div><div class="row"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12 menu-col"><div class="sec-title">Pathways</div> <span class="sectitle-span">+</span><ul><li><a href="/science/applications/research-areas/akt-signaling-pathway">AKT</a></li><li><a href="/science/applications/research-areas/jak-stat-signaling-pathway">JAK STAT</a></li><li><a href="/science/applications/research-areas/wnt-b-catenin-signaling-pathway">WNT B-Catenin</a></li></ul></div></div></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Neuroscience</div> <span class="sectitle-span">+</span><div class="sub-wrap"><div class="sec-subtitle"><a href="/science/applications/research-areas/neuroscience">Neuroscience</a></div><ul><li><a href="/science/applications/research-areas/neural-development">Neural Development</a></li><li><a href="/science/applications/research-areas/neuronal-cell-types">Neuronal Cell Types</a></li><li><a href="/science/applications/research-areas/learning-and-memory">Learning and Memory</a></li><li><a href="/science/applications/research-areas/g-protein-coupled-receptors-ion-channels">G-protein-coupled Receptors & Ion Channels</a></li><li><a href="/science/applications/research-areas/post-mortem-brain-tissue">Post-mortem Brain Tissue</a></li></ul></div></div></div><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Other</div> <span class="sectitle-span">+</span><ul><li><a href="/science/applications/research-solutions/circular-rna">Circular RNA</a></li><li><a href="/science/applications/research-solutions/gene-fusions">Gene Fusions</a></li><li><a href="/science/applications/research-solutions/ngsht-transcriptomic-validation-rna-seq">HT Transcript Validation</a></li><li><a href="/science/applications/research-solutions/long-noncoding-rna">Long Non-coding RNA</a></li><li><a href="/science/applications/research-solutions/ngsht-transcriptomic-validation-rna-seq">RNAseq Validation</a></li><li><a href="/science/applications/research-solutions/single-cell-analysis">Single Cell Analysis</a></li><li><a href="/science/applications/research-solutions/splice-variant">Splice Variant</a></li><li><a href="/science/applications/research-solutions/mirna">miRNA</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">RNA & Protein</div> <span class="sectitle-span">+</span><ul><li><a href="/science/applications/research-solutions/antibody-challenges-and-validation">Antibody Challenges</a></li><li><a href="/science/applications/research-solutions/dual-ish-and-ihc">Dual ISH + IHC Methods</a></li><li><a href="/science/applications/research-solutions/no-antibodies-available">No Antibodies</a></li><li><a href="/science/applications/research-solutions/ish-and-ihc-complementary">RNA & Protein Analysis</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Customer Innovations</div> <span class="sectitle-span">+</span><ul><li><a href="/innovations-rnascope">Dual RNA+DNA ISH</a></li><li><a href="/innovations-rnascope">Very old FFPE ISH</a></li><li><a href="/innovations-rnascope">Wholemount ISH</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Animal Models</div> <span class="sectitle-span">+</span><ul><li><a href="/science/applications/animal-models/virtually-any-species">Any Species</a></li><li><a href="/science/applications/animal-models/mouse-model">Mouse Model</a></li><li><a href="/science/applications/animal-models/preclinical-safety-assessment">Preclincal Safety</a></li></ul></div></div></div></div></li><li class="level0 technology"> <a href="/science/technology-overview" class="level0">Technology</a> <span class="level0 visible-xs">+</span><div class="menu-content"><div class="container"><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title"><a href="/science/technology-overview">Overview</a></div> <span class="sectitle-span">+</span><ul><li><a href="/science/how-it-works">How it Works</a></li><li><a href="/science/technology-overview/image-gallery">Data Image Gallery</a></li><li><a href="https://www.youtube.com/watch?v=CPgZEf6EyJQ&feature=youtu.be" target="_blank">Technology Video</a></li><li><a href="/technical-support/learn-more">Webinars</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">RNA Detection</div> <span class="sectitle-span">+</span><ul><li><a href="/science/why-rna">Why RNA?</a></li><li><a href="/science/applications/rna-ish-ihc/overview">RNA ISH and IHC</a></li></ul><div class="sec-title">Pretreatment Options</div> <span class="sectitle-span">+</span><ul><li><a href="/rnascope%E2%84%A2-pretreatment">RNAscope™ Pretreatment</a></li><li><a href="/PretreatmentOptions">PretreatPro™</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title"><a href="/science/spotlights">Spotlights</a></div> <span class="sectitle-span">+</span><ul><li><a href="/researcherspotlight">Researchers Spotlights</a></li><li><a href="/innovation/rna-dna">RNA & DNA</a></li><li><a href="/innovation/wish">WISH</a></li><li><a href="/innovation/ffpe">FFPE</a></li><li><a href="/customers">Testimonials</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Publications, Guides & Posters</div> <span class="sectitle-span">+</span><ul><li><a href="/science/scientific-resources/publications">Search publications</a></li><li><a href="/ebook/introduction">RNAscope™ Reference Guide</a></li><li><a href="/data-analysis/introduction">RNAscope™ Data Analysis Guide</a></li><li><a href="/science/posters">Download RNAscope™ Posters</a></li></ul></div></div></div></div></li><li class="level0 support"> <a href="/technical-support/support-overview" class="level0">Support</a> <span class="level0 visible-xs">+</span><div class="menu-content"><div class="container"><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Overview</div> <span class="sectitle-span">+</span><ul><li><a href="/technical-support/getting-started">Get Started</a></li><li><a href="/products/how-to-order">How to Order</a></li><li><a href="/about/distributors">Distributors</a></li><li><a href="/about/contact">Contact Support</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Troubleshooting</div> <span class="sectitle-span">+</span><ul><li><a href="/technical-support/solutions">Troubleshooting Guide</a></li><li><a href="/technical-support/solutions/faq">FAQs</a></li><li><a href="/documents/product-documents">User Manuals, SDS and Product Inserts</a></li><li><a href="/documents/product-documents">Documents and Downloads</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Imaging Resource</div> <span class="sectitle-span">+</span><ul><li><a href="/image-analysis">Image Analysis</a></li><li><a href="/image-registration-software">Image Registration Software</a></li><li><a href="/qupath-rna-ish-analysis">QuPath</a></li><li><a href="/halo-image-analysis-platform-new">HALO<sup>®</sup> image analysis platform</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title"><a href="/technical-support/learn-more">Learn More</a></div> <span class="sectitle-span">+</span><ul><li><a href="/technical-support/learn-more/recorded-webinars">Webinars</a></li><li><a href="/technical-support/learn-more">Training Videos</a></li></ul></div></div></div></div></li><li class="level0 assay col-3"> <a href="/partners-overview" class="level0">Partners</a> <span class="level0 visible-xs">+</span><div class="menu-content"><div class="container"><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Partners</div> <span class="sectitle-span">+</span><ul><li><a href="/partners-overview">Overview</a></li></ul></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title"><a href="/partners-directory">Partners Directory</a></div> <span class="sectitle-span">+</span><div class="sub-wrap"><div class="sec-subtitle">Automation Partners</div><ul><li><a href="/automated-assay-leica">Leica Biosystem</a></li><li><a href="/automated-assay-ventana">Roche Diagnostics</a></li></ul></div><div class="sub-wrap"><div class="sec-subtitle">Workflow Partners</div><ul><li><a href="/nanostring-partnership">NanoString</a></li></ul></div><div class="sub-wrap"><div class="sec-subtitle">Software Partners</div><ul><li><a href="/halo-image-analysis-platform">indica labs</a></li></ul></div></div><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Become a Partner</div> <span class="sectitle-span">+</span><ul><li><a href="/become-partner">Learn How</a></li></ul></div></div></div></div></li><li class="level0 diagnostics col-1"> <a href="/rnascope%C2%AE-diagnostics" class="level0">Diagnostics</a> <span class="level0 visible-xs">+</span><div class="menu-content"><div class="container"><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Diagnostics</div> <span class="sectitle-span">+</span><ul><li><a href="/rnascope%C2%AE-diagnostics">Diagnostics</a></li><li><a href="/diagnostics-literature">Literature</a></li><li><a href="/rnascope%E2%84%A2-ish-probes-detection-kappa-lambda-and-igll5">Diagnostics ASR Probes</a></li><li><a href="/rnascope-ish-probe-high-risk-hpv-head-neck-cancer">Diagnostics CE-IVD Probes</a></li><li><a href="/rnascope-ce-ivd-detection">Diagnostics CE-IVD Detection</a></li><li><a href="/rnascope%C2%AE-ish-companion-diagnostics-cdx">Companion Diagnostics</a></li></ul></div></div></div></div></li><li class="level0 technology col-1"> <a href="/image-contest" class="level0">Image Calendar</a> <span class="level0 visible-xs">+</span><div class="menu-content"><div class="container"><div class="row menu__blocks"><div class="col-lg-3 col-md-3 col-sm-3 col-xs-12 menu-col"><div class="sec-title">Image Calendar</div> <span class="sectitle-span">+</span><ul><li><a href="/image-contest">Image Contest</a></li><li><a href="/data-image-gallery">Data Image Gallery</a></li></ul></div></div></div></div></li></ul></div><div class="col-lg-1 col-md-1 col-sm-1 col-xs-12 header-search search__button "><div class="search-icon">Search</div><div class="clear"></div></div></div></div> </header></div><div class="page-main-container"><div class="banner-container sticky"> <img class="img-banner" src="https://acdbio.com/sites/default/files/science-banner.jpg"><h1 class="general-title">Leader in RNA ISH Technology for Spatial Gene Expression</h1></div><div class="container publications-container"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs" id="myTab"><li><a href="/science/technology-overview">ISH Technology</a></li><li><a href="/science/applications">Applications</a></li><li><a href="/science/why-rna">Why RNA ISH?</a></li><li><a href="/science/spotlights">Spotlights</a></li><li class="active"><a href="/science/scientific-resources/publications">Publications</a></li><li><a href="/science/posters">Posters</a></li></ul></div><div class="annual-container"><div class="annual-count"><div class="annual-count-left"><div class="annual-count-title">Annual Publication Count</div><div class="sub-title">Cumulative publications:</div><div class="count">10,000+</div><div class="updated">* Updated July, 2024</div></div><div class="annual-count-right"><img alt="" src="/sites/default/files/publications-july-2024.jpg" style="max-width:100%;" /></div><div class="clear"></div></div></div><div class="search-publications-container view-publications page-search"><div class="search-publications-title"> Search for Publications in RNAscope-Referenced Publication List<div class="public-search-form"><form action="/science/scientific-resources/publications/multiplex/product/rnascope<sup><sup>®</sup></sup>-multiplex-fluorescent-assay/product/rnascope<sup><sup>®</sup></sup>-ls-multiplex-assay" method="post" id="publication-search-form" accept-charset="UTF-8"><div><div class="form-item form-type-textfield form-item-pubtext"> <input placeholder="Enter keywords, gene name, author name, PMID, etc" type="text" id="edit-pubtext" name="pubtext" value="" size="60" maxlength="128" class="form-text" /></div><input type="submit" id="edit-submit--2" name="op" value="Search Publication List" class="form-submit" /><input type="hidden" name="form_build_id" value="form-5umLlaN0g0xUcUG69RuAaSUqBaRK9ulyrzm0tWBjkt4" /><input type="hidden" name="form_id" value="publication_search_form" /></div></form></div></div><div class="search-publications-count">Your search returned 1983 results</div><div class="container search-list"><div class="col-sm-3 filter"><div class="fil-res narrow-search"> Refine results</div><div class="fil-res"><div id="sidebar-first" class="sidebar"><div class="region region-sidebar-first"><div id="block-facetapi-mxdcbgdq1rrf3vzpdy1p2sog8tmjpps9" class="block block-facetapi clearfix"><h2 class="title">Filter by content type:</h2><div class="content"><div class="item-list"><ul class="facetapi-facetapi-checkbox-links facetapi-facet-bundle" id="facetapi-facet-apachesolrpublication-solr-server-block-bundle"><li class="leaf first last"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/bundle/publication" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link">Publication (1983)<span class="element-invisible"> Apply Publication filter </span></a></li></ul></div></div></div><div id="block-facetapi-kdj0uszhznr21fyegid2mqpuo8azmec6" class="block block-facetapi clearfix"><h2 class="title">Research area</h2><div class="content"><div class="item-list"><ul class="facetapi-facetapi-checkbox-links facetapi-facet-im-field-research-area" id="facetapi-facet-apachesolrpublication-solr-server-block-im-field-research-area"><li class="leaf first"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/neuroscience" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--52">Neuroscience (1026)<span class="element-invisible"> Apply Neuroscience filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/development" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--53">Development (244)<span class="element-invisible"> Apply Development filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/cancer" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--54">Cancer (179)<span class="element-invisible"> Apply Cancer filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/inflammation" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--55">Inflammation (121)<span class="element-invisible"> Apply Inflammation filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/stem-cells" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--56">Stem Cells (87)<span class="element-invisible"> Apply Stem Cells filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/other" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--57">Other (85)<span class="element-invisible"> Apply Other filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/infectious-disease" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--58">Infectious Disease (44)<span class="element-invisible"> Apply Infectious Disease filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/metabolism" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--59">Metabolism (41)<span class="element-invisible"> Apply Metabolism filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/covid" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--60">Covid (41)<span class="element-invisible"> Apply Covid filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/stem-cell" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--61">Stem cell (39)<span class="element-invisible"> Apply Stem cell filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/lncrna" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--62">lncRNA (38)<span class="element-invisible"> Apply lncRNA filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/infectious" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--63">Infectious (36)<span class="element-invisible"> Apply Infectious filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/developmental" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--64">Developmental (28)<span class="element-invisible"> Apply Developmental filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/cgt" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--65">CGT (21)<span class="element-invisible"> Apply CGT filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/diabetes" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--66">diabetes (18)<span class="element-invisible"> Apply diabetes filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/pain" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--67">Pain (18)<span class="element-invisible"> Apply Pain filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/aging" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--68">Aging (18)<span class="element-invisible"> Apply Aging filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/behavior" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--69">Behavior (17)<span class="element-invisible"> Apply Behavior filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/other-methods" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--70">Other: Methods (15)<span class="element-invisible"> Apply Other: Methods filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/other-metabolism" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--71">Other: Metabolism (15)<span class="element-invisible"> Apply Other: Metabolism filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/behavioral" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--72">behavioral (13)<span class="element-invisible"> Apply behavioral filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/endocrinology" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--73">Endocrinology (12)<span class="element-invisible"> Apply Endocrinology filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/regeneration" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--74">Regeneration (12)<span class="element-invisible"> Apply Regeneration filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/alzheimers-disease" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--75">Alzheimer's Disease (12)<span class="element-invisible"> Apply Alzheimer's Disease filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/other-heart" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--76">Other: Heart (12)<span class="element-invisible"> Apply Other: Heart filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/hiv" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--77">HIV (12)<span class="element-invisible"> Apply HIV filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/psychiatry" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--78">Psychiatry (11)<span class="element-invisible"> Apply Psychiatry filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/bone" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--79">Bone (10)<span class="element-invisible"> Apply Bone filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/stress" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--80">Stress (10)<span class="element-invisible"> Apply Stress filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/obesity" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--81">Obesity (10)<span class="element-invisible"> Apply Obesity filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/immunotherapy" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--82">Immunotherapy (9)<span class="element-invisible"> Apply Immunotherapy filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/liver" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--83">Liver (9)<span class="element-invisible"> Apply Liver filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/lncrnas" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--84">LncRNAs (9)<span class="element-invisible"> Apply LncRNAs filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/kidney" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--85">Kidney (8)<span class="element-invisible"> Apply Kidney filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/lung" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--86">Lung (8)<span class="element-invisible"> Apply Lung filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/anxiety" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--87">Anxiety (8)<span class="element-invisible"> Apply Anxiety filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/skin" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--88">Skin (7)<span class="element-invisible"> Apply Skin filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/sleep" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--89">Sleep (7)<span class="element-invisible"> Apply Sleep filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/injury" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--90">Injury (7)<span class="element-invisible"> Apply Injury filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/addiction" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--91">Addiction (7)<span class="element-invisible"> Apply Addiction filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/fibrosis" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--92">Fibrosis (7)<span class="element-invisible"> Apply Fibrosis filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/other-endocrinology" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--93">Other: Endocrinology (6)<span class="element-invisible"> Apply Other: Endocrinology filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/feeding-behavior" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--94">Feeding Behavior (6)<span class="element-invisible"> Apply Feeding Behavior filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/heart" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--95">Heart (6)<span class="element-invisible"> Apply Heart filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/sex-differences" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--96">Sex Differences (6)<span class="element-invisible"> Apply Sex Differences filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/schizophrenia" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--97">Schizophrenia (6)<span class="element-invisible"> Apply Schizophrenia filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/immunology" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--98">Immunology (5)<span class="element-invisible"> Apply Immunology filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/memory" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--99">Memory (5)<span class="element-invisible"> Apply Memory filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/other-cell-biology" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--100">Other: Cell Biology (5)<span class="element-invisible"> Apply Other: Cell Biology filter </span></a></li><li class="leaf last"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/researcharea/other-kidney" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--101">Other: Kidney (5)<span class="element-invisible"> Apply Other: Kidney filter </span></a></li></ul></div></div></div><div id="block-facetapi-4qghbqioaspbmlriwmxbgpyg084wdrpv" class="block block-facetapi clearfix"><h2 class="title">Species common</h2><div class="content"><div class="item-list"><ul class="facetapi-facetapi-checkbox-links facetapi-facet-im-field-species-common" id="facetapi-facet-apachesolrpublication-solr-server-block-im-field-species-common"><li class="leaf first"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/mouse" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--2">Mouse (1253)<span class="element-invisible"> Apply Mouse filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/human" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--3">Human (381)<span class="element-invisible"> Apply Human filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/rat" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--4">Rat (117)<span class="element-invisible"> Apply Rat filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/zebrafish" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--5">Zebrafish (61)<span class="element-invisible"> Apply Zebrafish filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/tbd" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--6">TBD (58)<span class="element-invisible"> Apply TBD filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/rats" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--7">Rats (35)<span class="element-invisible"> Apply Rats filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/monkey" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--8">Monkey (15)<span class="element-invisible"> Apply Monkey filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/macaque" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--9">Macaque (13)<span class="element-invisible"> Apply Macaque filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/other" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--10">Other (8)<span class="element-invisible"> Apply Other filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/chicken" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--11">Chicken (8)<span class="element-invisible"> Apply Chicken filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/drosophila" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--12">Drosophila (7)<span class="element-invisible"> Apply Drosophila filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/hamster" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--13">Hamster (6)<span class="element-invisible"> Apply Hamster filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/pig" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--14">Pig (3)<span class="element-invisible"> Apply Pig filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/rainbow-trout" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--15">rainbow trout (3)<span class="element-invisible"> Apply rainbow trout filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/monkeys" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--16">Monkeys (3)<span class="element-invisible"> Apply Monkeys filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/dog" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--17">Dog (2)<span class="element-invisible"> Apply Dog filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/zebra-finch" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--18">Zebra Finch (2)<span class="element-invisible"> Apply Zebra Finch filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/mouse-humanized" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--19">Mouse (Humanized) (2)<span class="element-invisible"> Apply Mouse (Humanized) filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/macaques" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--20">Macaques (2)<span class="element-invisible"> Apply Macaques filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/mosquito" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--21">Mosquito (2)<span class="element-invisible"> Apply Mosquito filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--22">Fly (2)<span class="element-invisible"> Apply Fly filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/trichoplax-adhaerens" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--23">Trichoplax adhaerens (2)<span class="element-invisible"> Apply Trichoplax adhaerens filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/mouse-embryo" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--24">Mouse embryo (2)<span class="element-invisible"> Apply Mouse embryo filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/bovine" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--25">Bovine (1)<span class="element-invisible"> Apply Bovine filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/hepatitis-b-virus" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--26">Hepatitis B virus (1)<span class="element-invisible"> Apply Hepatitis B virus filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fruit-fly" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--27">Fruit Fly (1)<span class="element-invisible"> Apply Fruit Fly filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/sheep" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--28">Sheep (1)<span class="element-invisible"> Apply Sheep filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/japanese-medaka" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--29">Japanese medaka (1)<span class="element-invisible"> Apply Japanese medaka filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/guinea-pig" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--30">Guinea pig (1)<span class="element-invisible"> Apply Guinea pig filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/canine" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--31">Canine (1)<span class="element-invisible"> Apply Canine filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/salmon" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--32">Salmon (1)<span class="element-invisible"> Apply Salmon filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/honey-bee" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--33">honey bee (1)<span class="element-invisible"> Apply honey bee filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/chimpanzee" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--34">chimpanzee (1)<span class="element-invisible"> Apply chimpanzee filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/marmoset" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--35">Marmoset (1)<span class="element-invisible"> Apply Marmoset filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fish" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--36">Fish (1)<span class="element-invisible"> Apply Fish filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/mouse-human-probes" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--37">Mouse (Human Probes) (1)<span class="element-invisible"> Apply Mouse (Human Probes) filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/bat" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--38">Bat (1)<span class="element-invisible"> Apply Bat filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/frog" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--39">Frog (1)<span class="element-invisible"> Apply Frog filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/ferret" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--40">Ferret (1)<span class="element-invisible"> Apply Ferret filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/locust" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--41">Locust (1)<span class="element-invisible"> Apply Locust filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/salamander" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--42">Salamander (1)<span class="element-invisible"> Apply Salamander filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/mouse-0" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--43">Mouse ? (1)<span class="element-invisible"> Apply Mouse ? filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/medaka%C2%A0" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--44">Medaka (1)<span class="element-invisible"> Apply Medaka filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/avian" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--45">Avian (1)<span class="element-invisible"> Apply Avian filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/rhesus-macaques" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--46">rhesus macaques (1)<span class="element-invisible"> Apply rhesus macaques filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/budgerigars" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--47">Budgerigars (1)<span class="element-invisible"> Apply Budgerigars filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/zebrafish%C2%A0" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--48">Zebrafish (1)<span class="element-invisible"> Apply Zebrafish filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/monocyte-derived-macrophages" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--49">Monocyte-derived macrophages (1)<span class="element-invisible"> Apply Monocyte-derived macrophages filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/human-cell-cultures" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--50">Human Cell Cultures (1)<span class="element-invisible"> Apply Human Cell Cultures filter </span></a></li><li class="leaf last"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/murine" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--51">Murine (1)<span class="element-invisible"> Apply Murine filter </span></a></li></ul></div></div></div><div id="block-facetapi-me8miflrpzemzgefduwk3xxabiv13rxf" class="block block-facetapi clearfix"><h2 class="title">Product</h2><div class="content"><div class="item-list"><ul class="facetapi-facetapi-checkbox-links facetapi-facet-im-field-product" id="facetapi-facet-apachesolrpublication-solr-server-block-im-field-product"><li class="leaf first"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-multiplex-fluorescent-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--102">RNAscope Multiplex Fluorescent Assay (1035)<span class="element-invisible"> Apply RNAscope Multiplex Fluorescent Assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-fluorescent-multiplex-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--103">RNAscope Fluorescent Multiplex Assay (732)<span class="element-invisible"> Apply RNAscope Fluorescent Multiplex Assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-multiplex-fluorescent-v2" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--104">RNAscope Multiplex Fluorescent v2 (97)<span class="element-invisible"> Apply RNAscope Multiplex Fluorescent v2 filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--105">RNAscope (26)<span class="element-invisible"> Apply RNAscope filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-multiplex-fluorescent-reagent-kit-v2" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--106">RNAscope Multiplex fluorescent reagent kit v2 (6)<span class="element-invisible"> Apply RNAscope Multiplex fluorescent reagent kit v2 filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-hiplex-v2-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--107">RNAscope HiPlex v2 assay (6)<span class="element-invisible"> Apply RNAscope HiPlex v2 assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-25-ls-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--108">RNAscope 2.5 LS Assay (6)<span class="element-invisible"> Apply RNAscope 2.5 LS Assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-fluorescent-multiplex-reagent-kit" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--109">RNAscope Fluorescent Multiplex Reagent kit (5)<span class="element-invisible"> Apply RNAscope Fluorescent Multiplex Reagent kit filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-25-hd-brown-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--110">RNAscope 2.5 HD Brown Assay (5)<span class="element-invisible"> Apply RNAscope 2.5 HD Brown Assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-25-hd-red-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--111">RNAscope 2.5 HD Red assay (4)<span class="element-invisible"> Apply RNAscope 2.5 HD Red assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/tbd" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--112">TBD (3)<span class="element-invisible"> Apply TBD filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-multiplex-fluorescent-assay-v2" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--113">RNAscope Multiplex Fluorescent Assay v2 (2)<span class="element-invisible"> Apply RNAscope Multiplex Fluorescent Assay v2 filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-20-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--114">RNAscope 2.0 Assay (2)<span class="element-invisible"> Apply RNAscope 2.0 Assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-hiplex12-reagents-kit" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--115">RNAscope HiPlex12 Reagents Kit (2)<span class="element-invisible"> Apply RNAscope HiPlex12 Reagents Kit filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/ctcscope" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--116">CTCscope (1)<span class="element-invisible"> Apply CTCscope filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-ls-multiplex-fluorescent-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--117">RNAscope LS Multiplex Fluorescent Assay (1)<span class="element-invisible"> Apply RNAscope LS Multiplex Fluorescent Assay filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/basescope" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--118">Basescope (1)<span class="element-invisible"> Apply Basescope filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-multiplex-fluorescent-v1" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--119">RNAscope Multiplex Fluorescent v1 (1)<span class="element-invisible"> Apply RNAscope Multiplex Fluorescent v1 filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-multiplex-fluorescent-reagent-kit-v3" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--120">RNAscope Multiplex Fluorescent Reagent Kit V3 (1)<span class="element-invisible"> Apply RNAscope Multiplex Fluorescent Reagent Kit V3 filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-hiplex-image-registration-software" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--121">RNAscope HiPlex Image Registration Software (1)<span class="element-invisible"> Apply RNAscope HiPlex Image Registration Software filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-25-hd-duplex-0" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--122">RNAscope 2.5 HD Duplex (1)<span class="element-invisible"> Apply RNAscope 2.5 HD Duplex filter </span></a></li><li class="leaf last"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/product/rnascope-multiplex-fluorescent-reagent-kit-v4" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--123">RNAscope Multiplex Fluorescent Reagent Kit v4 (1)<span class="element-invisible"> Apply RNAscope Multiplex Fluorescent Reagent Kit v4 filter </span></a></li></ul></div></div></div></div></div></div></div><div class="col-sm-9 result"><div class="region region-content"><div id="block-system-main" class="block block-system clearfix"><div class="content"><div class="search-results apachesolr_search-results"><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name">Highly Sensitive and Multiplexed In Situ RNA Profiling with Cleavable Fluorescent Tyramide</div></div><div class="col-sm-2"><p>Cells</p></div><div class="col-sm-2"><p>2021 May 21</p></div><div class="clear"></div><div class="col-sm-8"><p> Xiao, L;Labaer, J;Guo, J; <br/> PMID: 34063986 | DOI: 10.3390/cells10061277</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Understanding the composition, regulation, and function of complex biological systems requires tools that quantify multiple transcripts at their native cellular locations. However, the current multiplexed RNA imaging technologies are limited by their relatively low sensitivity or specificity, which hinders their applications in studying highly autofluorescent tissues, such as formalin-fixed paraffin-embedded (FFPE) tissues. To address this issue, here we develop a multiplexed in situ RNA profiling approach with a high sensitivity and specificity. In this approach, transcripts are first hybridized by target-specific oligonucleotide probes in pairs. Only when these two independent probes hybridize to the target in tandem will the subsequent signal amplification by oligonucleotide hybridization occur. Afterwards, horseradish peroxidase (HRP) is applied to further amplify the signal and stain the target with cleavable fluorescent tyramide (CFT). After imaging, the fluorophores are chemically cleaved and the hybridized probes are stripped by DNase and formamide. Through cycles of RNA staining, fluorescence imaging, signal cleavage, and probe stripping, many different RNA species can be profiled at the optical resolution. In applying this approach, we demonstrated that multiplexed in situ RNA analysis can be successfully achieved in both fixed, frozen, and FFPE tissues.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name">RNASCOPE MULTIPLEX IN SITU HYBRIDIZATION: A POWERFUL COMPLEMENT FOR STUDIES OF PROTEIN-PROTEIN INTERACTIONS IN COMPLEX TISSUES.</div></div><div class="col-sm-2"><p>Kidney International Reports</p></div><div class="col-sm-2"><p>2021 Apr 01</p></div><div class="clear"></div><div class="col-sm-8"><p> Lemay, S;Masztalerz, A;Baldwin, C;Chen, E;Takano, T; <br/> | DOI: 10.1016/j.ekir.2021.03.087</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Introduction Protein-protein interactions form the basis most physiological and pathophysiological mechanisms, but studying them at the tissue level is challenging, especially when they are transient, weak or involve low-abundance molecules in complex tissues. The problem is compounded when using antibody-based approaches, due to the paucity of rigorously validated antibodies for in situ studies. To circumvent these limitations, novel in situ hybridization (ISH) techniques present a number of advantages: 1) simple design of highly sensitive and specific probes for any species; 2) rapid probe synthesis; 3) uniform staining protocol across all probes; 4) efficient and reliable multiplexing, including in combination with antibodies or alternative staining approaches. Methods We are using RNAscope (ACD/Bio-Techne) ISH to examine the role of interactions involving the epithelial adapter protein Dok-4 injury models in wild type (WT) and Dok-4 null (KO) mice obtained by CRISPR/CAS9-induced frame shift. Novel interactions were identified by yeast two-hybrid and BioID method. For ISH, paraffin-embedded tissue was stained according to standard protocol either with chromogenic (DAB) method or multiplex fluorescence method. Dok-4 RNAscope probes were obtained from ACD and designed to be either overlapping or not with the short Dok-4 mRNA mismatch present in the KO mice. This allowed us to validate the specificity of the assay on one hand and to pinpoint the expected sites of Dok-4 protein expression (in WT) and deficiency (in KO). For EdU staining, EdU (ClickChemistry) was administered 2 hours before euthanasia and detected with Azide-Fluor 488 (Thermo). Results In both kidney and intestine, multiplex ISH demonstrated overlapping Dok-4 and EGFR mRNA expression. Partner identification could be also multiplexed with ISH probes for nephron segment identity (UMOD) or cellular injury (KIM1). Additionally, ISH could be multiplexed with validated immunofluorescence antibodies, such as to the proximal tubule marker AQP1, and with a marker of proliferation (EdU staining). In a mouse model of irradiation enteritis, directionally opposed but overlapping epithelial mRNA gradients of Dok-4 (dominant in differentiated villi) and its novel partner EGF receptor (dominant in undifferentiated crypts) could be demonstrated. Notably, increased EdU staining found 3 days after irradiation was concentrated in this area of Dok-4/EGFR overlap. Conclusions Multiplex ISH is a highly sensitive, specific and flexible approach to complement proteomics and biochemical interaction studies. Multiplexing for partner molecules can confirm the in vivo relevance of protein-protein interactions defined and validated in more rudimentary systems. Multiplexing can also be done with markers of nephron segment identity, tissue injury or repair, and more. Notably, in transgenic models where mRNA is minimally altered (such as with CRISPR/CAS9 methods), ISH can allow more focused phenotypic studies by delineating the predominant sites of targeted protein deficiency at the single cell level.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://europepmc.org/article/med/34605820"> Detection of G Protein-coupled Receptor Expression in Mouse Vagal Afferent Neurons using Multiplex In Situ Hybridization </a></div></div><div class="col-sm-2"><p>Journal of visualized experiments : JoVE</p></div><div class="col-sm-2"><p>2021 Sep 20</p></div><div class="clear"></div><div class="col-sm-8"><p> Bob-Manuel, J;Gautron, L; <br/> PMID: <a href="https://europepmc.org/article/med/34605820" target="_blank">34605820</a> | DOI: 10.3791/62945</p></div><div class="clear"></div><div class="descp publication-abstract-read"> This study describes a protocol for the multiplex in situ hybridization (ISH) of the mouse jugular-nodose ganglia, with a particular emphasis on detecting the expression of G protein-coupled receptors (GPCRs). Formalin-fixed jugular-nodose ganglia were processed with the RNAscope technology to simultaneously detect the expression of two representative GPCRs (cholecystokinin and ghrelin receptors) in combination with one marker gene of either nodose (paired-like homeobox 2b, Phox2b) or jugular afferent neurons (PR domain zinc finger protein 12, Prdm12). Labeled ganglia were imaged using confocal microscopy to determine the distribution and expression patterns of the aforementioned transcripts. Briefly, Phox2b afferent neurons were found to abundantly express the cholecystokinin receptor (Cck1r) but not the ghrelin receptor (Ghsr). A small subset of Prdm12 afferent neurons was also found to express Ghsr and/or Cck1r. Potential technical caveats in the design, processing, and interpretation of multiplex ISH are discussed. The approach described in this article may help scientists in generating accurate maps of the transcriptional profiles of vagal afferent neurons.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name">Clinical and research applications of multiplexed immunohistochemistry and in situ hybridization</div></div><div class="col-sm-2"><p>The Journal of pathology</p></div><div class="col-sm-2"><p>2021 Mar 15</p></div><div class="clear"></div><div class="col-sm-8"><p> McGinnis, LM;Ibarra-Lopez, V;Rost, S;Ziai, J; <br/> PMID: 33723864 | DOI: 10.1002/path.5663</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Over the past decade, invention and adoption of novel multiplexing technologies for tissues have made increasing impacts in basic and translational research and, to a lesser degree, clinical medicine. Platforms capable of highly multiplexed immunohistochemistry or in situ RNA measurements promise evaluation of protein or RNA targets at levels of plex and sensitivity logs above traditional methods - all with preservation of spatial context. These methods promise objective biomarker quantification, markedly increased sensitivity, and single-cell resolution. Increasingly, development of novel technologies is enabling multi-omic interrogations with spatial correlation of RNA and protein expression profiles in the same sample. Such sophisticated methods will provide unprecedented insights into tissue biology, biomarker science and, ultimately, patient health. However, this sophistication comes at significant cost, requiring extensive time, practical knowledge, and resources to implement. This review will describe the technical features, advantages, and limitations of currently available multiplexed immunohistochemistry and spatial transcriptomic platforms. This article is protected by</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://www.nature.com/articles/s41467-022-34606-w"> Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis </a></div></div><div class="col-sm-2"><p>Nature communications</p></div><div class="col-sm-2"><p>2023 Feb 09</p></div><div class="clear"></div><div class="col-sm-8"><p> Li, X;Li, Y;Xiao, J;Wang, H;Guo, Y;Mao, X;Shi, P;Hou, Y;Zhang, X;Zhao, N;Zheng, M;He, Y;Ding, J;Tan, Y;Liao, M;Li, L;Peng, Y;Li, X;Pan, Q;Xie, Q;Li, Q;Li, J;Li, Y;Chen, Z;Huang, Y;Assis, DN;Cai, SY;Boyer, JL;Huang, X;Tang, CE;Liu, X;Peng, S;Chai, J; <br/> PMID: <a href="https://www.nature.com/articles/s41467-022-34606-w" target="_blank">36759512</a> | DOI: 10.1038/s41467-022-34606-w</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Cholangiocytes play a crucial role in bile formation. Cholangiocyte injury causes cholestasis, including primary biliary cholangitis (PBC). However, the etiology of PBC remains unclear despite being characterized as an autoimmune disease. Using single-cell RNA sequencing (scRNA-seq), fluorescence-activated-cell-sorting, multiplex immunofluorescence (IF) and RNAscope analyses, we identified unique DUOX2+ACE2+ small cholangiocytes in human and mouse livers. Their selective decrease in PBC patients was associated with the severity of disease. Moreover, proteomics, scRNA-seq, and qPCR analyses indicated that polymeric immunoglobulin receptor (pIgR) was highly expressed in DUOX2+ACE2+ cholangiocytes. Serum anti-pIgR autoantibody levels were significantly increased in PBC patients, regardless of positive and negative AMA-M2. Spatial transcriptomics and multiplex IF revealed that CD27+ memory B and plasma cells accumulated in the hepatic portal tracts of PBC patients. Collectively, DUOX2+ACE2+ small cholangiocytes are pathogenic targets in PBC, and preservation of DUOX2+ACE2+ cholangiocytes and targeting anti-pIgR autoantibodies may be valuable strategies for therapeutic interventions in PBC.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://pubs.acs.org/doi/abs/10.1021/acschemneuro.1c00715"> Optogenetic Stimulation of Midbrain Dopamine Neurons Produces Striatal Serotonin Release </a></div></div><div class="col-sm-2"><p>ACS chemical neuroscience</p></div><div class="col-sm-2"><p>2022 Mar 21</p></div><div class="clear"></div><div class="col-sm-8"><p> Dagher, M;Perrotta, KA;Erwin, SA;Hachisuka, A;Iyer, R;Masmanidis, SC;Yang, H;Andrews, AM; <br/> PMID: <a href="https://pubs.acs.org/doi/abs/10.1021/acschemneuro.1c00715" target="_blank">35312275</a> | DOI: 10.1021/acschemneuro.1c00715</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Targeting neurons with light-driven opsins is widely used to investigate cell-specific responses. We transfected midbrain dopamine neurons with the excitatory opsin Chrimson. Extracellular basal and stimulated neurotransmitter levels in the dorsal striatum were measured by microdialysis in awake mice. Optical activation of dopamine cell bodies evoked terminal dopamine release in the striatum. Multiplexed analysis of dialysate samples revealed that the evoked dopamine was accompanied by temporally coupled increases in striatal 3-methoxytyramine, an extracellular dopamine metabolite, and in serotonin. We investigated a mechanism for dopamine-serotonin interactions involving striatal dopamine receptors. However, the evoked serotonin associated with optical stimulation of dopamine neurons was not abolished by striatal D1- or D2-like receptor inhibition. Although the mechanisms underlying the coupling of striatal dopamine and serotonin remain unclear, these findings illustrate advantages of multiplexed measurements for uncovering functional interactions between neurotransmitter systems. Furthermore, they suggest that the output of optogenetic manipulations may extend beyond opsin-expressing neuronal populations.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://www.sciencedirect.com/science/article/pii/S200103702200410X"> Navigating the cellular landscape in tissue: Recent advances in defining the pathogenesis of human disease </a></div></div><div class="col-sm-2"><p>Computational and Structural Biotechnology Journal</p></div><div class="col-sm-2"><p>2022 Sep 15</p></div><div class="clear"></div><div class="col-sm-8"><p> Chen, H;Palendira, U;Feng, C; <br/> | DOI: 10.1016/j.csbj.2022.09.005</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Over the past decade, our understanding of human diseases has rapidly grown from the rise of single-cell spatial biology. While conventional tissue imaging has focused on visualizing morphological features, the development of multiplex tissue imaging from fluorescence-based methods to DNA- and mass cytometry-based methods has allowed visualization of over 60 markers on a single tissue section. The advancement of spatial biology with a single-cell resolution has enabled the visualization of cell-cell interactions and the tissue microenvironment, a crucial part to understanding the mechanisms underlying pathogenesis. Alongside the development of extensive marker panels which can distinguish distinct cell phenotypes, multiplex tissue imaging has facilitated the analysis of high dimensional data to identify novel biomarkers and therapeutic targets, while considering the spatial context of the cellular environment. This mini-review provides an overview of the recent advancements in multiplex imaging technologies and examines how these methods have been used in exploring pathogenesis and biomarker discovery in cancer, autoimmune and infectious diseases.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://www.nature.com/articles/s41467-022-30168-z"> PICASSO allows ultra-multiplexed fluorescence imaging of spatially overlapping proteins without reference spectra measurements </a></div></div><div class="col-sm-2"><p>Nature communications</p></div><div class="col-sm-2"><p>2022 May 05</p></div><div class="clear"></div><div class="col-sm-8"><p> Seo, J;Sim, Y;Kim, J;Kim, H;Cho, I;Nam, H;Yoon, YG;Chang, JB; <br/> PMID: <a href="https://www.nature.com/articles/s41467-022-30168-z" target="_blank">35513404</a> | DOI: 10.1038/s41467-022-30168-z</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Ultra-multiplexed fluorescence imaging requires the use of spectrally overlapping fluorophores to label proteins and then to unmix the images of the fluorophores. However, doing this remains a challenge, especially in highly heterogeneous specimens, such as the brain, owing to the high degree of variation in the emission spectra of fluorophores in such specimens. Here, we propose PICASSO, which enables more than 15-color imaging of spatially overlapping proteins in a single imaging round without using any reference emission spectra. PICASSO requires an equal number of images and fluorophores, which enables such advanced multiplexed imaging, even with bandpass filter-based microscopy. We show that PICASSO can be used to achieve strong multiplexing capability in diverse applications. By combining PICASSO with cyclic immunofluorescence staining, we achieve 45-color imaging of the mouse brain in three cycles. PICASSO provides a tool for multiplexed imaging with high accessibility and accuracy for a broad range of researchers.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name">Virus-Dependent Immune Conditioning of Tissue Microenvironments</div></div><div class="col-sm-2"><p>SSRN Electronic Journal</p></div><div class="col-sm-2"><p>2021 Jun 13</p></div><div class="clear"></div><div class="col-sm-8"><p> Jiang, S;Chan, C;Rovira-Clavé, X;Chen, H;Bai, Y;Zhu, B;McCaffrey, E;Greenwald, N;Liu, C;Barlow, G;Weirather, J;Oliveria, J;Phillips, D;Mukherjee, N;Busman-Sahay, K;Nekorchuk, M;Terry, M;Younger, S;Bosse, M;Demeter, J;Golstev, Y;McIlwain, D;Angelo, M;Estes, J;Nolan, G; <br/> | DOI: 10.2139/ssrn.3860320</p></div><div class="clear"></div><div class="descp publication-abstract-read"> A thorough understanding of complex spatial host-disease interactions _in situ_ is necessary in order to develop effective preventative measures and therapeutic strategies. Here, we developed Protein And Nucleic acid IN situ Imaging (PANINI) and coupled it with Multiplexed Ion Beam Imaging (MIBI) to sensitively and simultaneously quantify DNA, RNA, and protein levels within the microenvironments of tissue compartments. The PANINI-MIBI approach was used to measure over 30 parameters simultaneously across large sections of archival lymphoid tissues from non-human primates that were healthy or infected with simian immunodeficiency virus (SIV), a model that accurately recapitulates human immunodeficiency virus infection (HIV). This enabled multiplexed dissection of cellular phenotypes, functional markers, viral DNA integration events, and viral RNA transcripts as resulting from viral infection. The results demonstrated immune coordination from an unexpected upregulation of IL10 in B cells in response to SIV infection that correlated with macrophage M2 polarization, thus conditioning a potential immunosuppressive environment that allows for viral production. This multiplexed imaging strategy also allowed characterization of the coordinated microenvironment around latently or actively infected cells to provide mechanistic insights into the process of viral latency. The spatial multi-modal framework presented here is applicable to deciphering tissue responses in other infectious diseases and tumor biology.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://www.science.org/doi/abs/10.1126/sciadv.abh2007"> REV-ERB nuclear receptors in the suprachiasmatic nucleus control circadian period and restrict diet-induced obesity </a></div></div><div class="col-sm-2"><p>Science advances</p></div><div class="col-sm-2"><p>2021 Oct 29</p></div><div class="clear"></div><div class="col-sm-8"><p> Adlanmerini, M;Krusen, BM;Nguyen, HCB;Teng, CW;Woodie, LN;Tackenberg, MC;Geisler, CE;Gaisinsky, J;Peed, LC;Carpenter, BJ;Hayes, MR;Lazar, MA; <br/> PMID: <a href="https://www.science.org/doi/abs/10.1126/sciadv.abh2007" target="_blank">34705514</a> | DOI: 10.1126/sciadv.abh2007</p></div><div class="clear"></div><div class="descp publication-abstract-read"> [Figure: see text].</div></div></div><h2 class="element-invisible">Pages</h2><div class="item-list"><ul class="pager"><li class="pager-current first">1</li><li class="pager-item"><a title="Go to page 2" href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay?page=1">2</a></li><li class="pager-item"><a title="Go to page 3" href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay?page=2">3</a></li><li class="pager-item"><a title="Go to page 4" href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay?page=3">4</a></li><li class="pager-item"><a title="Go to page 5" href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay?page=4">5</a></li><li class="pager-item"><a title="Go to page 6" href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay?page=5">6</a></li><li class="pager-item"><a title="Go to page 7" href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay?page=6">7</a></li><li class="pager-item"><a title="Go to page 8" href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay?page=7">8</a></li><li class="pager-item"><a title="Go to page 9" href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay?page=8">9</a></li><li class="pager-ellipsis">…</li><li class="pager-next"><a title="Go to next page" href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay?page=1">next ›</a></li><li class="pager-last last"><a title="Go to last page" href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay?page=198">last »</a></li></ul></div><div id="probes-info-table" class="search-probes-info"><div class="ecom-feature-container"><div class="help-ticket-close ">X</div><div class="ecom-feature-content"><div class="probes-help-text classification"><table cellspacing="0" border="0"><colgroup span="3" width="85"></colgroup><thead><tr><th></th><th>Description</th></tr></thead><tbody><tr><td>sense<br><strong>Example:</strong> Hs-LAG3-sense</td><td>Standard probes for RNA detection are in antisense. Sense probe is reverse complent to the corresponding antisense probe.</td></tr><tr><td>Intron#<br><strong>Example:</strong> Mm-Htt-intron2</td><td>Probe targets the indicated intron in the target gene, commonly used for pre-mRNA detection</td></tr><tr><td>Pool/Pan<br><strong>Example:</strong> Hs-CD3-pool (Hs-CD3D, Hs-CD3E, Hs-CD3G)</td><td>A mixture of multiple probe sets targeting multiple genes or transcripts</td></tr><tr><td>No-XSp<br><strong>Example:</strong> Hs-PDGFB-No-XMm</td><td>Does not cross detect with the species (Sp)</td></tr><tr><td>XSp<br><strong>Example:</strong> Rn-Pde9a-XMm</td><td>designed to cross detect with the species (Sp)</td></tr><tr><td>O#<br><strong>Example:</strong> Mm-Islr-O1</td><td>Alternative design targeting different regions of the same transcript or isoforms</td></tr><tr><td>CDS<br><strong>Example:</strong> Hs-SLC31A-CDS</td><td>Probe targets the protein-coding sequence only</td></tr><tr><td>EnEm</td><td>Probe targets exons n and m</td></tr><tr><td>En-Em</td><td>Probe targets region from exon n to exon m</td></tr><tr><td colspan=3 style="text-align: center; font-weight: bold;">Retired Nomenclature</td></tr><tr><td>tvn<br><strong>Example:</strong> Hs-LEPR-tv1</td><td>Designed to target transcript variant n</td></tr><tr><td>ORF<br><strong>Example:</strong> Hs-ACVRL1-ORF</td><td>Probe targets open reading frame</td></tr><tr><td>UTR<br><strong>Example:</strong> Hs-HTT-UTR-C3</td><td>Probe targets the untranslated region (non-protein-coding region) only</td></tr><tr><td>5UTR<br><strong>Example:</strong> Hs-GNRHR-5UTR</td><td>Probe targets the 5' untranslated region only</td></tr><tr><td>3UTR<br><strong>Example:</strong> Rn-Npy1r-3UTR</td><td>Probe targets the 3' untranslated region only</td></tr><tr><td>Pan<br><strong>Example:</strong> Pool</td><td>A mixture of multiple probe sets targeting multiple genes or transcripts</td></tr></tbody></table></div></div></div></div> <script type="text/javascript"> jQuery(document).ready(function($) { $(".probes-info.gene-tooltip").click(function(e) { e.preventDefault(); e.stopPropagation(); }); $('.probes-info.gene-tooltip').on('click', function(){ $('.search-probes-info').addClass("active"); $('#probes-info-table').css('visibility', 'visible'); }); $('.help-ticket-close ').on('click',function(){ $('.search-probes-info').removeClass("active"); $('#probes-info-table').css('visibility', 'hidden'); }); $('#probes-info-table').on('click', function(event) { event.stopPropagation(); }); jQuery('.add-cart').click(function(){ var ping = jQuery(this).attr('ping'); var datalayerItems = [{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0}]; // Using jQuery.each() jQuery.each(datalayerItems, function(key, value) { // Inside this function, 'key' is the key of the current item, and 'value' is its value if (ping === value.item_id) { var selectedItem = datalayerItems[key]; selectedItem.index = 1; window.dataLayer = window.dataLayer || []; window.dataLayer.push({ ecommerce: null }); window.dataLayer.push({ 'event': 'add_to_cart', 'ecommerce': { 'currency': "", "items": selectedItem } }); } }); }); $('.pro-title.probe-title').click(function(event) { var ping = $(this).attr('ping'); var datalayerItems = [{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0}]; var tab = $(this).parents('.row-probes').find('.view-details-tab a'); var tabActive = $(this).parents('.row-probes').find('.view-details-tab'); if (!tabActive.hasClass('active')) { jQuery.each(datalayerItems, function(key, value) { if (ping === value.item_id) { var selectItem = datalayerItems[key]; selectItem.index = 1; window.dataLayer = window.dataLayer || []; window.dataLayer.push({ ecommerce: null }); window.dataLayer.push({ 'event': 'select_item', 'ecommerce': { 'currency': "", "items": selectItem } }); } }); } if(!tab.hasClass('disabled')){ if($(window).width() < 768){ id = tab.attr("href"); tab.parent('li').toggleClass('active'); tab.next().find(id).slideToggle('slow'); setTimeout(function(){ $('html, body').animate({ scrollTop: tab.offset().top - 80 }, 500); }, 500); ele = $(".tab-content.mobile .tab-pane").not(tab.next().children('.tab-pane')); ele.slideUp('fast'); ele.parent().prev().parent().removeClass('active'); }else{ id = tab.attr("href"); tab.closest('.pro-detail-tab').children('.tab-content.desktop').find('.tab-pane').slideUp('fast'); if(tab.parent('li').hasClass('active')){ tab.closest('#probeTab').find('li').removeClass('active'); tab.closest('.pro-detail-tab').children('.tab-content.desktop').find(id).slideUp('fast'); }else{ tab.closest('#probeTab').find('li').removeClass('active'); tab.parent('li').addClass('active'); tab.closest('.pro-detail-tab').children('.tab-content.desktop').find(id).slideToggle('slow'); } } } }); $('#probeTab a').click(function (event) { event.preventDefault(); var tab = $(this); var ping = $(this).attr('ping'); var datalayerItems = [{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0}]; var previousEle = tab.parent(); // Using jQuery.each() if (!previousEle.hasClass('active')) { jQuery.each(datalayerItems, function(key, value) { if (ping === value.item_id) { var selectItem = datalayerItems[key]; selectItem.index = 1; window.dataLayer = window.dataLayer || []; window.dataLayer.push({ ecommerce: null }); window.dataLayer.push({ 'event': 'select_item', 'ecommerce': { 'currency': "", "items": selectItem } }); } }); } if(!tab.hasClass('disabled')){ if($(window).width() < 768){ id = tab.attr("href"); tab.parent('li').toggleClass('active'); tab.next().find(id).slideToggle('slow'); setTimeout(function(){ $('html, body').animate({ scrollTop: tab.offset().top - 80 }, 500); }, 500); ele = $(".tab-content.mobile .tab-pane").not(tab.next().children('.tab-pane')); ele.slideUp('fast'); ele.parent().prev().parent().removeClass('active'); }else{ id = tab.attr("href"); tab.closest('.pro-detail-tab').children('.tab-content.desktop').find('.tab-pane').slideUp('fast'); if(tab.parent('li').hasClass('active')){ tab.closest('#probeTab').find('li').removeClass('active'); tab.closest('.pro-detail-tab').children('.tab-content.desktop').find(id).slideUp('fast'); }else{ tab.closest('#probeTab').find('li').removeClass('active'); tab.parent('li').addClass('active'); tab.closest('.pro-detail-tab').children('.tab-content.desktop').find(id).slideToggle('slow'); } } } }); }); jQuery(document).mouseup(function(e){ var container = jQuery(".search-probes-info"); if (!container.is(e.target) && container.has(e.target).length === 0) { jQuery('.search-probes-info').removeClass("active"); jQuery('#probes-info-table').css('visibility', 'hidden'); } }); </script> <script> window.dataLayer = window.dataLayer || []; window.dataLayer.push({ ecommerce: null }); window.dataLayer.push({ 'event': 'view_item_list', 'ecommerce': { 'currency': "", "items": [{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0},{"item_id":null,"item_name":null,"item_brand":null,"item_category":null,"item_category2":null,"item_category3":null,"item_category4":null,"item_category5":null,"item_variant":null,"affiliation":null,"price":null,"quantity":null,"discount":null,"item_list_id":null,"item_list_name":null,"index":0}] } }); </script> </div></div></div></div></div></div></div></div><div class="region region-footer"><div class="footer-container"><div class="footer"><div class="footer-contact-enabling"><div class="footer-enable-wrap"><div class="footer-enable-research"><p>Enabling research, drug development (CDx) and diagnostics</p></div><div class="footer-contact-us"> <a class="help-ticket" href="#help-ticket-id">Contact Us</a></div></div><div class="links logo-col"><div class="footer-logo"> <img src="/sites/all/themes/acd/images/logo-dwn.PNG" alt=""></div><ul><li>Toll-free in the US and Canada</li><li>+1877 576-3636</li></ul><div class="footer-social visible-xs"><ul><li class="first"><a href="https://www.facebook.com/Advanced-Cell-Diagnostics-Inc-207947755916438/" class="ss-icon"></a></li><li><a href="https://in.linkedin.com/company/advanced-cell-diagnostics" class="ss-icon"></a></li><li class="last"><a href="https://twitter.com/ACDbio" class="ss-icon"></a></li></ul></div></div></div><div class="footer_links"><div class="links first"><div class="block-title"><strong>Company</strong></div><ul class="links"><li class="menu-838 first"><a href="/about" title="">Overview</a></li><li class="menu-698"><a href="/about/leadership" title="">Leadership</a></li><li class="menu-700"><a href="/about/careers" title="">Careers</a></li><li class="menu-702"><a href="/about/distributors" title="">Distributors</a></li><li class="menu-1371"><a href="/about/quality" title="">Quality</a></li><li class="menu-699"><a href="/about/news" title="">News & Events</a></li><li class="menu-1163"><a href="/technical-support/learn-more" title="">Webinars</a></li><li class="menu-1043 last"><a href="/patents" title="">Patents</a></li></ul></div><div class="links links-products"><div class="block-title"><strong>Products</strong></div><ul class="links"><li class="menu-1362 first"><a href="/rnascope-basescope-and-mirnascope-assays" title="">RNAscope or BaseScope</a></li><li class="menu-714"><a href="/target-probes" title="">Target Probes</a></li><li class="menu-717"><a href="/control-slides-and-control-probes-rnascope" title="">Controls</a></li><li class="menu-715"><a href="/manual-assays-rnascope" title="">Manual assays</a></li><li class="menu-716"><a href="/automated-assay-leica" title="">Automated Assays</a></li><li class="menu-718"><a href="/instruments-accessories" title="">Accessories</a></li><li class="menu-719"><a href="/analysis-software" title="">Software</a></li><li class="menu-1252 last"><a href="/products/how-to-order" title="">How to Order</a></li></ul></div><div class="links links-com"><div class="block-title"><a href="/science/applications"><strong>Research</strong></a></div><ul class="links"><li class="menu-1352 first"><a href="/science/applications/research-areas/inflammation" title="">Popular Applications</a></li><li class="menu-1353"><a href="/science/applications/research-areas/cancer" title="">Cancer</a></li><li class="menu-1354"><a href="/science/applications/research-areas/hiv-siv" title="">Viral</a></li><li class="menu-1355"><a href="/science/applications/research-areas/akt-signaling-pathway" title="">Pathways</a></li><li class="menu-1356"><a href="/science/applications/research-areas/neuroscience" title="">Neuroscience</a></li><li class="menu-1357"><a href="/science/applications/research-solutions/anatomic-pathology-panels" title="">Other Applications</a></li><li class="menu-1358"><a href="/science/applications/research-solutions/antibody-validation-and-challenges" title="">RNA & Protein</a></li><li class="menu-1359"><a href="/innovations-rnascope" title="">Customer Innovations</a></li><li class="menu-1360 last"><a href="/science/applications/animal-models/virtually-any-species" title="">Animal Models</a></li></ul></div><div class="links links-science"><div class="block-title"><strong>Technology</strong></div><ul class="links"><li class="menu-706 first"><a href="/science/technology-overview" title="">Overview</a></li><li class="menu-837"><a href="/science/why-rna" title="">RNA Detection</a></li><li class="menu-1361"><a href="/researcherspotlight" title="">Spotlight Interviews</a></li><li class="menu-974 last"><a href="/science/scientific-resources/publications" title="">Publications & Guides</a></li></ul></div><div class="links links-services"><div class="block-title"><strong>Assay Services</strong></div><ul class="links"><li class="menu-1080 first"><a href="/pas" title="">Our Services</a></li><li class="menu-1363"><a href="/biomarker-assay-development" title="">Biomarker Assay Development</a></li><li class="menu-1365"><a href="/cell-gene-therapy-services" title="">Cell & Gene Therapy Services</a></li><li class="menu-899"><a href="/services/CDx-prototype" title="">Clinical Assay Development</a></li><li class="menu-1364"><a href="/services/acd-tissue-bank" title="">Tissue Bank & Sample Procurement</a></li><li class="menu-882"><a href="/services/quantitative-analysis" title="">Image Analysis</a></li><li class="menu-883"><a href="/services/your-benefits-your-success" title="">Your Benefits</a></li><li class="menu-1244 last"><a href="/services/how-order" title="">How to Order</a></li></ul></div><div class="links links-diagnostics"><div class="block-title"><strong>Diagnostics</strong></div><ul class="links"><li class="menu-1349 first"><a href="/diagnostics" title="">Diagnostics</a></li><li class="menu-1350 last"><a href="/companion-diagnostics" title="">Companion Diagnostics</a></li></ul></div><div class="links last"><div class="block-title"><strong>Support</strong></div><ul class="links"><li class="menu-725 first"><a href="/technical-support/getting-started" title="">Getting started</a></li><li class="menu-729"><a href="/about/contact" title="">Contact Support</a></li><li class="menu-1366"><a href="/technical-support/solutions" title="">Troubleshooting Guide</a></li><li class="menu-1367"><a href="/technical-support/solutions/faq" title="">FAQs</a></li><li class="menu-726"><a href="/technical-support/user-manuals" title="">Manuals, SDS & Inserts</a></li><li class="menu-877"><a href="/documents/product-documents" title="">Downloads</a></li><li class="menu-1368"><a href="/technical-support/learn-more/recorded-webinars" title="">Webinars</a></li><li class="menu-1369 last"><a href="/technical-support/learn-more/training-videos" title="">Training Videos</a></li></ul></div><div class="clear"></div></div><div class="footer-middle"><p>Visit Bio-Techne and its other brands</p><ul><li><a href="https://www.bio-techne.com/" class="bio-technie" target="_blank">bio-technie</a></li><li><a href="https://www.bio-techne.com/brands/proteinsimple/" class="protein" target="_blank">protein</a></li><li><a href="http://www.biospacific.com/" class="bio-spacific" target="_blank">bio-spacific</a></li><li><a href="https://www.rndsystems.com/" class="rd" target="_blank">rd</a></li><li><a href="https://www.novusbio.com/" class="novus" target="_blank">novus</a></li><li class="last"><a href="https://www.tocris.com/" class="tocris" target="_blank">tocris</a></li></ul></div><div class="footer-bottom"> <address class="copyright"> © 2024 Advanced Cell Diagnostics, Inc. </address><div class="footer-bottom-links"><ul class="links"><li class="menu-732 first"><a href="https://acdbio.com/store/terms" title="">Terms and Conditions of Sale</a></li><li class="menu-733"><a href="https://acdbio.com/store/privacy-policy" title="">Privacy Policy</a></li><li class="menu-734"><a href="https://acdbio.com/store/security" title="">Security</a></li><li class="menu-915 last"><a href="https://info.acdbio.com/ACD-Update-Profile.html" title="">Email Preferences</a></li></ul></div><div class="footer-social hidden-xs"><ul><li class="first"><a href="https://www.facebook.com/Advanced-Cell-Diagnostics-Inc-207947755916438/" class="ss-icon"></a></li><li><a href="https://in.linkedin.com/company/advanced-cell-diagnostics" class="ss-icon"></a></li><li class="last"><a href="https://twitter.com/ACDbio" class="ss-icon"></a></li></ul></div></div><div class="clear"></div><div class="global-footer"><p>For Research Use Only. Not for diagnostic use. Refer to appropriate regulations. RNAscope is a registered trademark; and HybEZ, EZ-Batch and DNAscope are trademarks of Advanced Cell Diagnostics, Inc. in the United States and other countries. All rights reserved. ©2024 Advanced Cell Diagnostics, Inc.</p><p> </p></div><div class="contact-link-right"> <a href="#help-ticket-id"><span>Contact Us / Request a Quote</span></a></div><div class="download-link-right"> <a href="/documents/product-documents"><span>Download Manuals</span></a></div><div class="pas-lead-link-right"> <a href="https://info.bio-techne.com/WEB-ACD-2023-07-PAS-Lead-Capture-Assay-Services-7398_01-LP-Main.html" target="_blank"><span>Request a PAS Project Consultation</span></a></div></div></div></div> <script> jQuery( document ).ready(function() { if (getPopupCookie('setpopup') == 1) { jQuery('.setpopup-overlay').css({'display':'block'}); jQuery('.setpopup-modal').css({'display':'block'}); } jQuery('.setpopup-modal-close').click(function(e) { e.preventDefault(); jQuery('.setpopup-overlay').css({'display':'none'}); jQuery('.setpopup-modal').css({'display':'none'}); setPopupCookie("setpopup", 0, 7); }); }); function setPopupCookie(cname, cvalue, exdays) { var d = new Date(); d.setTime(d.getTime() + (exdays*24*60*60*1000)); var expires = "expires="+ d.toUTCString(); document.cookie = cname + "=" + cvalue + ";" + expires + ";path=/"; } function getPopupCookie(cname) { var name = cname + "="; var decodedCookie = decodeURIComponent(document.cookie); var ca = decodedCookie.split(';'); for(var i = 0; i <ca.length; i++) { var c = ca[i]; while (c.charAt(0) == ' ') { c = c.substring(1); } if (c.indexOf(name) == 0) { return c.substring(name.length, c.length); } } return null; } </script> <style> .setpopup-overlay{ top: 0; left: 0; width: 100%; height: 100%; z-index: 1042; overflow: hidden; position: fixed; background: #0b0b0b; opacity: 0.8; display: none; } </style><div class="popup-success-message" id="popup-success-message"><div class="popup-loader"> <svg viewBox="0 0 64 64"><g fill="none" fill-rule="evenodd" stroke-width="3"><circle cx="32" cy="32"><animate attributeName="r" begin="0s" dur="2s" values="0;24" keyTimes="0;1" keySplines="0.1,0.2,0.3,1" calcMode="spline" repeatCount="indefinite"/><animate attributeName="stroke-opacity" begin="0s" dur="2s" values=".2;1;.2;0" repeatCount="indefinite"/></circle><circle cx="32" cy="32"><animate attributeName="r" begin="-1s" dur="2s" values="0;24" keyTimes="0;1" keySplines="0.1,0.2,0.3,1" calcMode="spline" repeatCount="indefinite"/><animate attributeName="stroke-opacity" begin="-1s" dur="2s" values=".2;1;.2;0" repeatCount="indefinite"/></circle></g></svg></div><div class="popup-content"><div class="popup-message"></div> <a class="popup-success-message_close">OK</a></div></div><div class="region region-contactform"><div id="help-ticket-id" class="help-ticket-popup mfp-hide"><div class="open-ticket-contents"><div class="help-ticket-close">X</div><div class="ticket-content"><div class="ticket-content-inner"><div class="ticket-content-top"><div class="needhelp-title">Contact Us</div><p>Complete one of the three forms below and we will get back to you.</p><p>For Quote Requests, please provide more details in the Contact Sales form below</p></div><div class="needhelp-tab"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs" id="help-tictab"><li class="active"><a data-toggle="tab" href="#contactsales">Contact Sales</a></li><li><a data-toggle="tab" href="#contactsupport">Contact Support</a></li><li><a data-toggle="tab" href="#contactpharma">Contact Services</a></li><li><a data-toggle="tab" href="#contactinfo">Offices</a></li></ul></div><div class="tab-content"><div class="needhelp-tab-container tab-pane fade in active" id="contactsales"><div class="supportform-con"><div class="contact-tab-form supportform-con"> <script src="//info.bio-techne.com/js/forms2/js/forms2.min.js"></script> <form id="mktoForm_9816"></form> <script>MktoForms2.loadForm("//info.bio-techne.com", "584-XSF-168", 9816);</script> </div></div></div><div class="needhelp-tab-container tab-pane fade" id="contactsupport"><div class="supportform-con"><form action="https://proteinsimple--obtfull.my.salesforce.com/servlet/servlet.WebToCase?encoding=UTF-8" id="web-to-case1" method="POST"><div class="row"><div class="col-md-6"> <label for="fname">First Name</label> <input id="fname" maxlength="80" name="fname" size="20" type="text"></div><div class="col-md-6"> <label for="lname">Last Name</label> <input id="lname" maxlength="80" name="lname" size="20" type="text"></div></div><div class="row"><div class="col-md-6"> <label for="email">Email</label> <input id="email" maxlength="80" name="email" size="20" type="text"></div><div class="col-md-6"> <label for="phone">Phone</label> <input id="phone" maxlength="40" name="phone" size="20" type="text"></div></div><div class="row"><div class="col-md-6"> <label for="company">Institution / Company</label> <input id="company" maxlength="80" name="company" size="20" type="text"></div></div><div class="row"><div class="col-md-12"> <label for="description">Message</label> <textarea name="description"></textarea> </div></div><div class="row captcha"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"> <label>Type the characters that you see in the picture below</label> <input type="text" id="PageCaseCaptcha" disabled /> <a class="btnrefresh" onclick="DrawCaptcha();"></a></div></div><div class="row captcha"><div class="col-lg-12 col-md-12 col-sm-12 col-xs-12"> <input type="text" class="case_captcha" id="PageCaseInput" name="case_captcha"/><div id="pagecasecaptcha-error"></div></div></div> <input type="submit" name="submit" style="float:left;" onclick="ValidCaptcha('pagecase');"><div class="clear"></div></form></div></div><div class="needhelp-tab-container tab-pane fade" id="contactinfo"><div class="supportform-con contact-info"><div class="row"><h3>Advanced Cell Diagnostics</h3><p>Our new headquarters office starting May 2016:</p><p>7707 Gateway Blvd. <br />Newark, CA 94560<br />Toll Free: 1 (877) 576-3636<br />Phone: (510) 576-8800<br />Fax: (510) 576-8798</p></div><div class="row"><p> </p><div class="row"><h3>Bio-Techne</h3><p>19 Barton Lane <br />Abingdon Science Park<br />Abingdon<br />OX14 3NB<br />United Kingdom<br />Phone 2: +44 1235 529449<br />Fax: +44 1235 533420</p><p> </p></div><div class="row"><h3>Advanced Cell Diagnostics China</h3><p>20F, Tower 3,<br />Raffles City Changning Office,<br />1193 Changning Road, Shanghai 200051</p><p>021-52293200<br /><a href="mailto:info.cn@bio-techne.com">info.cn@bio-techne.com</a><br />Web: <a href="http://www.acdbio.com/cn">www.acdbio.com/cn</a></p></div><div class="row"><p>For general information: <a href="mailto:Info.ACD@bio-techne.com">Info.ACD@bio-techne.com</a><br />For place an order: <a href="mailto:order.ACD@bio-techne.com">order.ACD@bio-techne.com</a><br />For product support: <a href="mailto:support.ACD@bio-techne.com">support.ACD@bio-techne.com</a><br />For career opportunities: <a href="mailto:hr.ACD@bio-techne.com">hr.ACD@bio-techne.com</a></p></div></div><div class="row" style="border-bottom: none;"><div class="col-md-6"> <a href="/about/distributors" class="meet-out-sales-team" title="See Distributors">See Distributors</a></div></div></div></div><div class="needhelp-tab-container tab-pane fade" id="contactpharma"><div class="supportform-con"><div class="contact-tab-form supportform-con"><form id="mktoForm_9817"></form> <script>MktoForms2.loadForm("//info.bio-techne.com", "584-XSF-168", 9817);</script> </div></div></div></div></div></div></div></div></div></div> <script type="text/javascript"> jQuery(document).ready(function($) { $("#web-to-case1").validate({ // Specify the validation rules rules: { fname: "required", lname: "required", phone:"required", email: { required: true, email: true }, company: "required", case_captcha: "required" }, // Specify the validation error messages messages: { fname: "Please enter your First Name", lname: "Please enter your Last Name", email: "Please enter your email address", phone: "Please enter your Phone Number", company: "Please enter your Institution/Company", case_captcha: "Please Enter Valid Captcha." }, submitHandler: function(form) { var captchastatus = ValidCaptcha('pagecase'); //form.submit(); if(captchastatus == 'Success'){ $.ajax({ type: "POST", url: Drupal.settings.basePath + 'api/webtocase', data: { api : "obtwebtocase", fname : form.fname.value, lname : form.lname.value, email : form.email.value, phone : form.phone.value, company : form.company.value, description : form.description.value, url : form.action, }, beforeSend: function() { $('#popup-success-message').popup('show'); $('.popup-success-message .popup-loader').show(); $('.popup-success-message .popup-content').hide(); }, success: function(data){ if(data == "success"){ window.location.replace("https://acdbio.com/thank-you-contacting-acd"); }else{ $('.popup-success-message .popup-loader').hide(); $('.popup-success-message .popup-content').show(); $('.popup-success-message .popup-content .popup-message').html(data); } }, error: function(XMLHttpRequest, textStatus, errorThrown) { } }); } } }); $(document).on("click", '.contact-link-right a, a.help-ticket, .quote-request-btn a, a.top-help-contact', function(event) { var numItems = $('.open-ticket-contents #mktoForm_9816 .mktoFieldDescriptor').next('.mktoField.mktoFieldDescriptor').length; if(numItems == 1){ $('.open-ticket-contents #mktoForm_9816 .mktoFieldDescriptor').prevAll().remove(); } var numItems = $('.open-ticket-contents #mktoForm_9817 .mktoFieldDescriptor').next('.mktoField.mktoFieldDescriptor').length; if(numItems == 1){ $('.open-ticket-contents #mktoForm_9817 .mktoFieldDescriptor').prevAll().remove(); } }); }); </script> </div> <script type="text/javascript"> jQuery(document).ready(function($) { var windowsize = $(window).width(); if(windowsize < 768){ slidestart = $('#myTab li.active').index(); $('#myTab').bxSlider({ moveSlides: 1, minSlides: 1, maxSlides: 6, slideWidth: 200, //infiniteLoop: false, pager: false, //hideControlOnEnd: true, startSlide: slidestart }); } }); </script> <style type='text/css'> .embeddedServiceHelpButton .helpButton .uiButton { background-color: #005f9e; font-family: "Arial", sans-serif; max-width: none; } .embeddedServiceHelpButton .embeddedServiceIcon::before { font-size: 2.25em; } .embeddedServiceHelpButton .helpButton .uiButton:hover { background-color: #0097ed; } .embeddedServiceHelpButton .helpButton .uiButton:focus { outline: 1px solid #005290; text-decoration: none; } .embeddedServiceHelpButton .helpButton .uiButton:active { text-decoration: none; } .embeddedServiceHelpButton .helpButton .helpButtonEnabled:hover::before, .embeddedServiceHelpButton .helpButton .helpButtonEnabled:focus::before { background-color: #0097ed; text-decoration: none; } .message { background-color: inherit; border-style: none; color: #fff; margin: 4px 20px; font-size: large; } .embeddedServiceLiveAgentStateChatHeader.alert .message { margin: 0; } .embeddedServiceLiveAgentStateChatHeader:not(.alert) .message { margin: 0; width: auto; } span#helpButtonSpan { padding: 0 50px 0 30px; } .embeddedServiceLiveAgentStateChatHeaderOption .optionName { color: #ffffff; } /* hide the URL capture field and label */ #OmniURL__c { display: none; } .prechatUI .fieldList li:nth-child(6) label { display: none; } /* Added 10px margin-top to center header text */ .headerText { margin-top: 10px; } </style>  <style type='text/css'> #snapins_invite { position: fixed !important; background-color: #FFFFFF; font-family: "Arial", sans-serif; overflow: visible; border-radius: 8px; visibility: hidden; } .embeddedServiceInvitation { background-color: transparent; max-width: 290px; max-height: 210px; -webkit-box-shadow: 0 7px 12px rgba(0, 0, 0, 0.28); -moz-box-shadow: 0 7px 12px rgba(0, 0, 0, 0.28); box-shadow: 0 7px 12px rgba(0, 0, 0, 0.28); } @media only screen and (min-width: 48em) { /*mobile*/ .embeddedServiceInvitation { max-width: 332px; max-height: 210px; } } .embeddedServiceInvitation>.embeddedServiceInvitationHeader { width: inherit; height: 48px; line-height: auto; padding: 10px; color: #FFFFFF; background-color: #005f9e; overflow: initial; display: flex; justify-content: space-between; align-items: stretch; border-top-left-radius: 8px; border-top-right-radius: 8px; } .embeddedServiceInvitationHeader #embeddedServiceAvatar { width: 32px; height: 32px; border-radius: 50%; } .embeddedServiceInvitationHeader .embeddedServiceTitleText { font-size: 18px; color: #FFFFFF; overflow: hidden; word-wrap: normal; white-space: nowrap; text-overflow: ellipsis; align-self: stretch; flex-grow: 1; max-width: 100%; margin: 0 12px; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon { background-image: none; border: none; border-radius: 3px; cursor: pointer; position: relative; bottom: 3%; background-color: transparent; width: 32px; height: 32px; font-size: 23px; color: #FFFFFF; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:focus { outline: none; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:focus::before { content: " "; position: absolute; top: 11%; left: 7%; width: 85%; height: 85%; background-color: rgba(255, 255, 255, 0.2); border-radius: 4px; pointer-events: none; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:active, .embeddedServiceCloseIcon:hover { background-color: #FFFFFF; color: rgba(0, 0, 0, 0.7); opacity: 0.7; } .embeddedServiceInvitation>.embeddedServiceInvitationBody { background-color: #FFFFFF; max-height: 110px; min-width: 260px; margin: 0 8px; font-size: 14px; line-height: 20px; overflow: auto; } .embeddedServiceInvitationBody p { color: #333333; padding: 8px; margin: 12px 0; } .embeddedServiceInvitation>.embeddedServiceInvitationFooter { width: inherit; color: #FFFFFF; text-align: right; background-color: #FFFFFF; padding: 10px; max-height: none; border-bottom-left-radius: 8px; border-bottom-right-radius: 8px; margin-bottom: 10px; } .embeddedServiceInvitationFooter>.embeddedServiceActionButton { font-size: 14px; max-height: 40px; border: none; border-radius: 4px; padding: 10px; margin: 4px; text-align: center; text-decoration: none; display: inline-block; cursor: pointer; } .embeddedServiceInvitationFooter>#acceptInvite { background-image: none; background-color: #005f9e; color: #FFFFFF; } .embeddedServiceInvitationFooter>#rejectInvite { background-image: none; background-color: #FFFFFF; color: #005f9e; } </style>   <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true"> <div class="embeddedServiceInvitationHeader" aria-labelledby="snapins_titletext" aria-describedby="snapins_bodytext"> <img id="embeddedServiceAvatar"></img> <span class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button type="button" id="closeInvite" class="embeddedServiceCloseIcon" aria-label="Exit invitation">×</button> </div> <div class="embeddedServiceInvitationBody"> <p id="snapins_bodytext">How can we help you?</p> </div> <div class="embeddedServiceInvitationFooter" aria-describedby="snapins_bodytext"> <button type="button" class="embeddedServiceActionButton" id="rejectInvite">Close</button> <button type="button" class="embeddedServiceActionButton" id="acceptInvite">Start Chat</button> </div> </div> <style type='text/css'> #snapins_invite { background-color: #FFFFFF; font-family: "Arial", sans-serif; overflow: visible; border-radius: 8px; visibility: hidden; } .embeddedServiceInvitation { background-color: transparent; max-width: 290px; max-height: 210px; -webkit-box-shadow: 0 7px 12px rgba(0,0,0,0.28); -moz-box-shadow: 0 7px 12px rgba(0,0,0,0.28); box-shadow: 0 7px 12px rgba(0,0,0,0.28); } @media only screen and (min-width: 48em) { /*mobile*/ .embeddedServiceInvitation { max-width: 332px; max-height: 210px; } } .embeddedServiceInvitation > .embeddedServiceInvitationHeader { width: inherit; height: 32px; line-height: 32px; padding: 10px; color: #FFFFFF; background-color: #222222; overflow: initial; display: flex; justify-content: space-between; align-items: stretch; border-top-left-radius: 8px; border-top-right-radius: 8px; } .embeddedServiceInvitationHeader #embeddedServiceAvatar { width: 32px; height: 32px; border-radius: 50%; } .embeddedServiceInvitationHeader .embeddedServiceTitleText { font-size: 18px; color: #FFFFFF; overflow: hidden; word-wrap: normal; white-space: nowrap; text-overflow: ellipsis; align-self: stretch; flex-grow: 1; max-width: 100%; margin: 0 12px; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon { border: none; border-radius: 3px; cursor: pointer; position: relative; bottom: 3%; background-color: transparent; width: 32px; height: 32px; font-size: 23px; color: #FFFFFF; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:focus { outline: none; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:focus::before { content: " "; position: absolute; top: 11%; left: 7%; width: 85%; height: 85%; background-color: rgba(255, 255, 255, 0.2); border-radius: 4px; pointer-events: none; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:active, .embeddedServiceCloseIcon:hover { background-color: #FFFFFF; color: rgba(0,0,0,0.7); opacity: 0.7; } .embeddedServiceInvitation > .embeddedServiceInvitationBody { background-color: #FFFFFF; max-height: 110px; min-width: 260px; margin: 0 8px; font-size: 14px; line-height: 20px; overflow: auto; } .embeddedServiceInvitationBody p { color: #333333; padding: 8px; margin: 12px 0; } .embeddedServiceInvitation > .embeddedServiceInvitationFooter { width: inherit; color: #FFFFFF; text-align: right; background-color: #FFFFFF; padding: 10px; max-height: 50px; border-bottom-left-radius: 8px; border-bottom-right-radius: 8px; } .embeddedServiceInvitationFooter > .embeddedServiceActionButton { font-size: 14px; max-height: 40px; border: none; border-radius: 4px; padding: 10px; margin: 4px; text-align: center; text-decoration: none; display: inline-block; cursor: pointer; } .embeddedServiceInvitationFooter > #acceptInvite { background-color: #005290; color: #FFFFFF; } .embeddedServiceInvitationFooter > #rejectInvite { background-color: #FFFFFF; color: #005290; } </style>   <input type="hidden" name="liveagent.prechat.findorcreate.map.doFind:Contact" value="LastName,true;FirstName,true;Email,true" /> <input type="hidden" name="liveagent.prechat.findorcreate.map.isExactMatch:Contact" value="LastName,true;FirstName,true;Email,true" /> <input type="hidden" name="liveagent.prechat.findorcreate.map.doCreate:Contact" value="LastName,true;FirstName,true;Email,true" /> <script type='text/javascript'> (function() { document.getElementById('closeInvite').onclick = function() { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }; document.getElementById('rejectInvite').onclick = function() { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }; // use this API call to reject invitations document.getElementById('acceptInvite').onclick = function() { embedded_svc.liveAgentAPI.startChat({ directToButtonRouting: { buttonId: "5733t000000cVk9" }, extraPrechatInfo: [], extraPrechatFormDetails: [] }); }; // use this API call to start chat from invitations document.addEventListener('keyup', function(event) { if (event.keyCode == 27) { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }}) })(); </script>  <script type='text/javascript' src='https://service.force.com/embeddedservice/5.0/esw.min.js'></script> <script type='text/javascript'> var initESW = function(gslbBaseURL) { embedded_svc.settings.displayHelpButton = true; //Or false embedded_svc.settings.language = ''; //For example, enter 'en' or 'en-US' embedded_svc.settings.defaultMinimizedText = 'Chat now'; //(Defaults to Chat with an Expert) embedded_svc.settings.disabledMinimizedText = 'Leave a message'; //(Defaults to Agent Offline) embedded_svc.settings.autoOpenPostChat = true; //embedded_svc.settings.loadingText = ''; //(Defaults to Loading) //embedded_svc.settings.storageDomain = 'yourdomain.com'; //(Sets the domain for your deployment so that visitors can navigate subdomains during a chat session) // Settings for Chat embedded_svc.settings.directToButtonRouting = function (prechatFormData) { if (prechatFormData[4].value === "Technical Service") return "5733t000000XZAM"; if (prechatFormData[4].value === "Customer Care") return "5733t000000XZAH"; }; embedded_svc.settings.prepopulatedPrechatFields = { OmniURL__c: window.location.href, ChooseaDepartment__c: 'Technical Service' }; //Sets the auto-population of pre-chat form fields embedded_svc.settings.extraPrechatFormDetails = [{ "label":"Source Domain", "value":window.location.href, "transcriptFields":[ "Source_Domain__c" ], "displayToAgent":true }]; //embedded_svc.settings.fallbackRouting = []; //An array of button IDs, user IDs, or userId_buttonId embedded_svc.settings.offlineSupportMinimizedText = 'Leave a message'; //(Defaults to Contact Us) embedded_svc.settings.enabledFeatures = ['LiveAgent']; embedded_svc.settings.entryFeature = 'LiveAgent'; embedded_svc.init( 'https://biotechne.my.salesforce.com', 'https://biotechne.my.salesforce-sites.com/LiveAgent', gslbBaseURL, '00D500000006gkl', 'ACD_Chat_Automated', { baseLiveAgentContentURL: 'https://c.la1-c1-ia5.salesforceliveagent.com/content', deploymentId: '572380000004CqL', buttonId: '5733t000000cVk9', baseLiveAgentURL: 'https://d.la1-c1-ia5.salesforceliveagent.com/chat', eswLiveAgentDevName: 'EmbeddedServiceLiveAgent_Parent04I3t000000Y7zbEAC_175bb741b99', isOfflineSupportEnabled: true } ); }; if (!window.embedded_svc) { var s = document.createElement('script'); s.setAttribute('src', 'https://biotechne.my.salesforce.com/embeddedservice/5.0/esw.min.js'); s.onload = function() { initESW(null); }; document.body.appendChild(s); } else { initESW('https://service.force.com'); } </script> <script src="//rum-static.pingdom.net/pa-5c133f6e1872b50016000024.js" async></script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"NRJS-dd6144c4de227d09eb4","applicationID":"1022125825","transactionName":"YFxbZkpUXBYEVkYNWVkWbEBRGlsLAVBKSkZfSQ==","queueTime":0,"applicationTime":343,"atts":"TBtYEAJOTxg=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>