MediAim – a translational research project

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<h1>A translational<br /> research<br /> <span>project</span></h1> <img src="/custom/img/homepage/hero-1-cary.png" /></div> </div> <div class="hero-homepage-prefetch"> </div> </div> <div class="signpost"> <div class="light-bg-1 padding-top-80 padding-top-sm-60 padding-top-xs-50 padding-bottom-100 padding-bottom-xs-50" id="homepage-row-1"> <div class="container"> <div class="row row-image-text d-flex"> <div class="col-lg-offset-6 col-md-offset-5 col-sm-offset-4 col-lg-6 col-md-7 col-sm-8"> <h2 class="text-left">What is MediAim</h2> </div> </div> <div class="row row-image-text d-flex"> <div class="col-lg-6 col-md-7 col-sm-8"> <p>The MediAim project is dedicated to the <strong>development of new therapeutic agents and strategies to fight certain serious noncommunicable diseases and selected viral diseases</strong>.</p> <p>Collaboration focuses on experimental, preclinical, translational, and clinical research on the nervous and cardiovascular systems with selected aspects of metabolic research. </p> <a class="margin-top-35 margin-top-xs-20 btn-1" href="/en/about-the-project">Read more about the project ></a></div> <div class="col-lg-6 col-md-5 col-sm-4 padding-right-md-40"><img class="img-responsive center-block" src="custom/img/homepage/obr-1.png" /></div> </div> </div> </div> <div class="container"> <div class="row margin-top-150 margin-top-md-80 margin-top-sm-60"> <div class="col-xs-12 text-center"> <h2 class="with-after">Research of diseases</h2> </div> </div> </div> <div class="module"> <div id="nemoci-vystup-homepage"> <div class="list"><div class="container padding-bottom-100 padding-bottom-xs-50"> <div class="row"> <div class="col-md-4 col-sm-6 nemoc-holder"> <a href="/en/diseases/1en-obesity" class="nemoc-shadow"> <div class="nemoc-border"> <div class="nemoc"> <div class="heading-holder"> <h3>Obesity</h3> </div> <div class="img-holder"> <img src="/doc/nemoci_img/obesity03-1.png" alt="Obesity" /> </div> </div> </div> </a> </div> <div class="col-md-4 col-sm-6 nemoc-holder"> <a href="/en/diseases/2en-diabetes-mellitus" class="nemoc-shadow"> <div class="nemoc-border"> <div class="nemoc"> <div class="heading-holder"> <h3>Diabetes mellitus</h3> </div> <div class="img-holder"> <img src="/doc/nemoci_img/diabetes03-2.png" alt="Diabetes mellitus" /> </div> </div> </div> </a> </div> <div class="col-md-4 col-sm-6 nemoc-holder"> <a href="/en/diseases/3en-cardiovascular-diseases" class="nemoc-shadow"> <div class="nemoc-border"> <div class="nemoc"> <div class="heading-holder"> <h3>Cardiovascular diseases</h3> </div> <div class="img-holder"> <img src="/doc/nemoci_img/heart03-3.png" alt="Cardiovascular diseases" /> </div> </div> </div> </a> </div> <div class="col-md-4 col-sm-6 nemoc-holder"> <a href="/en/diseases/4en-cns-diseases" class="nemoc-shadow"> <div class="nemoc-border"> <div class="nemoc"> <div class="heading-holder"> <h3>Diseases of the central nervous system</h3> </div> <div class="img-holder"> <img src="/doc/nemoci_img/nervous03-4.png" alt="Diseases of the central nervous system" /> </div> </div> </div> </a> </div> <div class="col-md-4 col-sm-6 nemoc-holder"> <a href="/en/diseases/5en-viral-diseases" class="nemoc-shadow"> <div class="nemoc-border"> <div class="nemoc"> <div class="heading-holder"> <h3>Viral diseases</h3> </div> <div class="img-holder"> <img src="/doc/nemoci_img/viry03-5.png" alt="Viral diseases" /> </div> </div> </div> </a> </div> <div class="col-md-4 col-sm-6 nemoc-holder"> <a href="/en/diseases/6en-oncologic-diseases" class="nemoc-shadow"> <div class="nemoc-border"> <div class="nemoc"> <div class="heading-holder"> <h3>Oncologic diseases</h3> </div> <div class="img-holder"> <img src="/doc/nemoci_img/cancer001-6.png" alt="Oncologic diseases" /> </div> </div> </div> </a> </div> </div> <div class="row margin-top-35"> <div class="col-xs-12 text-center"><a class="btn-1" href="/nemoci">More about our research ></a></div> </div> </div> </div> </div> </div> <div class="light-bg-1 padding-top-100 padding-top-md-80 padding-bottom-100 padding-bottom-xs-50"> <div class="container"> <div class="row"> <div class="col-xs-12"> <h2 class="with-after">Partners</h2> </div> </div> <div class="row "> <div class="col-xs-12 "> <div class="module"> <div id="partneri-vystup-homepage"> <div class="list"><div class="podporuji-nas"> <a href="/partneri#zaznam-stranka-1" class="podporuji-nas-item"> <img src="/doc/partneri_img/thumbnail_ikem-1.png" alt="Podporují nás" class="img-responsive" /> </a> <a href="/partneri#zaznam-stranka-2" class="podporuji-nas-item"> <img src="/doc/partneri_img/thumbnail_uochb-4.png" alt="Podporují nás" class="img-responsive" /> </a> <a href="/partneri#zaznam-stranka-3" class="podporuji-nas-item"> <img src="/doc/partneri_img/thumbnail_fuac-3.png" alt="Podporují nás" class="img-responsive" /> </a> </div> </div> </div> </div></div> </div> <div class="row margin-top-35"> <div class="col-xs-12 text-center"><a class="btn-1" href="/en/partners">Read more about the partners ></a></div> </div> </div> </div> <div class="padding-top-100 padding-top-md-80 padding-bottom-100 padding-bottom-xs-50"> <div class="container"> <div class="row"> <div class="col-xs-12"> <h2 class="with-after">Selected publications</h2> </div> </div> <div class="row "> <div class="col-xs-12 "> <div class="module"> <div id="publikace-vystup-homepage"> <div class="list"><div class="last-articles-widget"> <a href="/publikace" class="last-articles-widget-item"> <img src="/doc/publikace_img/autophagy-5.png" alt="Mitochondrial respiration supports autophagy to provide stress resistance during quiescence" class="img-responsive" /> <h3 class="heading">Mitochondrial respiration supports autophagy to provide stress resistance during quiescence</h3> <p class="autori">Magalhaes-Novais, S., Blecha, J., Naraine, R., Mikesova, J., Abaffy, P., Pecinová, A., Miloševič, M., Bohuslavová, R., Procházka, J., Khan, S., Novotná, E., Šindelka, R., Machan, R., Dewerchin, M., Vlčák, E., Kalucka, J., Štemberková-Hubáčková, S., Benda, A., Goveia, J., Mráček, T., Bařinka, C., Carmeliet, P., Neužil, J., Rohlenová, K., Rohlena, J.</p> <p class="casopis"><em>Autophagy</em>. 2022; 2022–03-21(MAR 2022)</p> </a> <a href="/publikace" class="last-articles-widget-item"> <img src="/doc/publikace_img/clinical-science-6.png" alt="NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose" class="img-responsive" /> <h3 class="heading">NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose</h3> <p class="autori">Karnošová, A., Strnadová, V., Železná, B., Kuneš, J., Kašpárek, P., Maletínská, L.</p> <p class="casopis"><em>Clinical science</em>. 2023; <strong>137</strong>(10); 847–862</p> </a> <a href="/publikace" class="last-articles-widget-item"> <img src="/doc/publikace_img/cellular-and-molecular-life-sciences-7.png" alt="Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids" class="img-responsive" /> <h3 class="heading">Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids</h3> <p class="autori">Kysilov, B., Kuchtiak, V., Hrčka Krausová, B., Balík, A., Kořínek, M., Fili, K., Dobrovolski, M., Abramová, V., Chodounská, H., Kudová, E., Božíková, P., Černý, J., Smejkalová, T., Vyklický ml., L.</p> <p class="casopis"><em>Cellular and Molecular Life Sciences</em>. 2024, <strong>81</strong>(1), 36</p> </a> </div> </div> </div> </div></div> </div> <div class="row margin-top-35 margin-top-xs-0"> <div class="col-xs-12 text-center"><a class="btn-1" href="/en/publications">Other publications ></a></div> </div> </div> </div> </div> </div> </div> </div>  <div id="footer" class="container-fluid"> <div class="container"> <div class="row"> <div 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MediAim – a translational research project