OASIS Repository@POSTECHLIBRARY: Comprehensive shape analysis of the cortex in Huntington's disease

<!DOCTYPE html> <html lang="ko"> <head> <title>OASIS Repository@POSTECHLIBRARY: Comprehensive shape analysis of the cortex in Huntington's disease</title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8" /> <meta name="Generator" content="DSpace 5.5" /> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="description" content="Postech OASIS Repository" /> <meta name="keywords" content="오아시스,레포지토리,리포지터리,저장소,포스텍,박태준학술정보관,포항공과대학교,포항공대,POSTECH,Pohang University of Science and Technology,도서관,IR,연구업적,학술실적,연구성과,dspace" /> <link rel="shortcut icon" href="/favicon.ico" type="image/x-icon"/> <link rel="search" type="application/opensearchdescription+xml" href="/open-search/description.xml" title="DSpace" /> <link rel="schema.DCTERMS" href="http://purl.org/dc/terms/" /> <link rel="schema.DC" href="http://purl.org/dc/elements/1.1/" /> <link rel="schema.OAK" href="http://www.oak.go.kr/terms/" /> <meta name="OAK.author" content="Stoebner, Zachary A." scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Hett, Kilian" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Lyu, Ilwoo" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Johnson, Hans" scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Paulsen, Jane S." scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Long, Jeffrey D." scheme="OAK.AUTHOR" /> <meta name="OAK.author" content="Oguz, Ipek" scheme="OAK.AUTHOR" /> <meta name="DCTERMS.dateAccepted" content="2024-03-05T06:20:33Z" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.available" content="2024-03-05T06:20:33Z" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.created" content="2024-03-04" scheme="DCTERMS.W3CDTF" /> <meta name="DCTERMS.issued" content="2023-03" scheme="DCTERMS.W3CDTF" /> <meta name="OAK.identifier.issn" content="1065-9471" scheme="OAK.ISSN" /> <meta name="DC.identifier" content="https://oasis.postech.ac.kr/handle/2014.oak/120898" scheme="DCTERMS.URI" /> <meta name="DCTERMS.abstract" content="The striatum has traditionally been the focus of Huntington&apos;s disease research due to the primary insult to this region and its central role in motor symptoms. Beyond the striatum, evidence of cortical alterations caused by Huntington&apos;s disease has surfaced. However, findings are not coherent between studies which have used cortical thickness for Huntington&apos;s disease since it is the well-established cortical metric of interest in other diseases. In this study, we propose a more comprehensive approach to cortical morphology in Huntington&apos;s disease using cortical thickness, sulcal depth, and local gyrification index. Our results show consistency with prior findings in cortical thickness, including its limitations. Our comparison between cortical thickness and local gyrification index underscores the complementary nature of these two measures—cortical thickness detects changes in the sensorimotor and posterior areas while local gyrification index identifies insular differences. Since local gyrification index and cortical thickness measures detect changes in different regions, the two used in tandem could provide a clinically relevant measure of disease progression. Our findings suggest that differences in insular regions may correspond to earlier neurodegeneration and may provide a complementary cortical measure for detection of subtle early cortical changes due to Huntington&apos;s disease. © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC." /> <meta name="DC.language" content="English" /> <meta name="DC.publisher" content="John Wiley & Sons Inc." /> <meta name="DC.relation" content="Human Brain Mapping" /> <meta name="DC.title" content="Comprehensive shape analysis of the cortex in Huntington&apos;s disease" /> <meta name="DC.type" content="Article" /> <meta name="DC.identifier" content="10.1002/hbm.26125" /> <meta name="DC.identifier" content="57169" /> <meta name="DC.type" content="ART" /> <meta name="DC.identifier" content="Human Brain Mapping, v.44, no.4, pp.1417 - 1431" /> <meta name="DC.identifier" content="000888554400001" /> <meta name="OAK.relation.page" content="1431" scheme="OAK.PAGE" /> <meta name="OAK.relation.issue" content="4" scheme="OAK.ISSUE" /> <meta name="OAK.relation.page" content="1417" scheme="OAK.PAGE" /> <meta name="OAK.relation.journal" content="Human Brain Mapping" scheme="OAK.JOURNAL" /> <meta name="OAK.relation.volume" content="44" scheme="OAK.VOLUME" /> <meta name="DC.contributor" content="Lyu, Ilwoo" /> <meta name="DC.identifier" content="2-s2.0-85142398022" /> <meta name="DC.description" content="1" /> <meta name="DC.description" content="1" /> <meta name="DC.description" content="Y" /> <meta name="DC.type" content="Article; Early Access" /> <meta name="DC.description" content="scie" /> <meta name="DC.description" content="scopus" /> <meta name="citation_keywords" content="Article" /> <meta name="citation_title" content="Comprehensive shape analysis of the cortex in Huntington&apos;s disease" /> <meta name="citation_issn" content="1065-9471" /> <meta name="citation_publisher" content="John Wiley & Sons Inc." /> <meta name="citation_author" content="Stoebner, Zachary A." /> <meta name="citation_author" content="Hett, Kilian" /> <meta name="citation_author" content="Lyu, Ilwoo" /> <meta name="citation_author" content="Johnson, Hans" /> <meta name="citation_author" content="Paulsen, Jane S." /> <meta name="citation_author" content="Long, Jeffrey D." /> <meta name="citation_author" content="Oguz, Ipek" /> <meta name="citation_date" content="2023-03" /> <meta name="citation_abstract_html_url" content="https://oasis.postech.ac.kr/handle/2014.oak/120898" /> <link rel="stylesheet" href="/css/bootstrap.min.css" defer /> <link rel="stylesheet" href="/css/layout.css" async /> <link rel="stylesheet" href="/css/mquery.css" defer /> <link rel="stylesheet" href="/css/slidebars.css" defer />  <link rel="stylesheet" href="/css/owl.carousel.css" defer />  <link rel="stylesheet" href="/css/owl.theme.css" defer /> <link rel="stylesheet" href="/css/bootstrap-partof.css" defer /> <script src="/js/jquery-1.9.1.min.js"></script> <script src="/js/jquery-ui.js"></script> <script src="/js/bootstrap.min.js"></script> <script src="/js/owl.carousel.min.js"></script> <script src="/js/common.js" defer></script> <script src="/utils.js" defer></script> <script src="/static/js/holder.js" defer></script> <script src="/static/js/choice-support.js" defer></script> <script src="/js/ms-clarity.js"></script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-B9EHYYGM78"></script> <script> window.dataLayer = window.dataLayer || []; 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Beyond the striatum, evidence of cortical alterations caused by Huntington's disease has surfaced. However, findings are not coherent between studies which have used cortical thickness for Huntington's disease since it is the well-established cortical metric of interest in other diseases. In this study, we propose a more comprehensive approach to cortical morphology in Huntington's disease using cortical thickness, sulcal depth, and local gyrification index. Our results show consistency with prior findings in cortical thickness, including its limitations. Our comparison between cortical thickness and local gyrification index underscores the complementary nature of these two measures—cortical thickness detects changes in the sensorimotor and posterior areas while local gyrification index identifies insular differences. Since local gyrification index and cortical thickness measures detect changes in different regions, the two used in tandem could provide a clinically relevant measure of disease progression. Our findings suggest that differences in insular regions may correspond to earlier neurodegeneration and may provide a complementary cortical measure for detection of subtle early cortical changes due to Huntington's disease. © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.</dd></dl> <dl><dt>URI</dt><dd><a href="https://oasis.postech.ac.kr/handle/2014.oak/120898" class="link_type">https://oasis.postech.ac.kr/handle/2014.oak/120898</a></dd></dl> <dl><dt>DOI</dt><dd><a href="http://dx.doi.org/10.1002/hbm.26125">10.1002/hbm.26125</a></dd></dl> <dl><dt>ISSN</dt><dd>1065-9471</dd></dl> <dl><dt>Article Type</dt><dd>Article</dd></dl> <dl><dt>Citation</dt><dd>Human Brain Mapping, vol. 44, no. 4, page. 1417 - 1431, 2023-03</dd></dl> <dl class="file_item_dl"><dt>Files in This Item:</dt> <dd class="file_download">There are no files associated with this item.</dd> </dl> </div> <div class="record_bt_box"> <a href="/handle/2014.oak/120898?mode=full">Show full item record</a> </div> <div class="al_right"> </div> <div class="sns_wrap"> <div class="sns_box"> <p class="qr_box"><img src="https://api.qrserver.com/v1/create-qr-code/?size=66x66&data=https://oasis.postech.ac.kr/handle/2014.oak/120898" alt="qr_code"></p> <div class="sns_inner"> <ul> <li> <p><a href="http://www.mendeley.com/import/?url=https://oasis.postech.ac.kr/handle/2014.oak/120898" target="_blank"><img src="/image/common/mendeley_icon.gif" alt="mendeley" /></a></p> <p class="twitter_box"> <a href="https://twitter.com/share" class="tweet_bt twitter-share-button" data-lang="en" data-size="large" data-dnt="true">트윗하기</a> <script> !function(d, s, id) { var js, fjs = d.getElementsByTagName(s)[0]; if (!d.getElementById(id)) { js = d.createElement(s); js.id = id; js.src = "//platform.twitter.com/widgets.js"; fjs.parentNode.insertBefore(js, fjs); } }(document, "script", "twitter-wjs"); </script> </p> </li> <li class="facebook_li"> <span id="fb-root"></span> <script> (function(d, s, id) { var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/ko_KR/all.js#xfbml=1"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); </script> <span class="fb-like" data-send="true" data-layout="standard" data-width="450" data-show-faces="false" data-font="verdana"></span> </li> </ul> </div> </div> <p class="sns_text"> <span> Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.</span> </p> </div> </div> </div>  <div class="sub_right_box"> <div class="w_cc"> <h4 class="widget_title">Communities & Collection</h4> <ul> <li><a href="/handle/2014.oak/110943" class="cc_item">Graduate School of Artificial Intelligence (인공지능대학원)</a> <ul> <li><a href="/handle/2014.oak/110945">1. 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OASIS Repository@POSTECHLIBRARY: Comprehensive shape analysis of the cortex in Huntington's disease