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</div> </div> <div id="email-action-panel" class="email-action-panel action-panel" aria-hidden="true" data-recaptcha-script-url="https://www.recaptcha.net/recaptcha/enterprise.js?render=explicit&onload=onloadCaptchaCallback" data-recaptcha-enabled="true"> <div class="inner-wrap"> <h2 class="action-panel-heading">Email citation</h2> <form id="email-action-panel-form" class="action-panel-content action-form" action="/send-email/" data-by-search-action="/results-export-email-by-search-data/" data-by-ids-action="/send-email/" data-by-search-method="post" data-by-ids-method="post" method="post"><input type="hidden" name="csrfmiddlewaretoken" value="KkshdUMOVQpqpQU71Jhk48QGE1IkNvi8HSnUKjODnKCBz0EKeuoCkhW8RJCRgxWX"> <div class="action-panel-control-wrap"><span class="action-panel-label"> Subject: </span> <span class="email-subject" id="email-subject" aria-label="Email subject">1 selected item: 30500180 - PubMed</span> <input type="hidden" name="email-subject" value="1 selected item: 30500180"> <input type="hidden" name="email-subject-hash" value="279a918894240aae0acd2ab184d6c924c016fa8951c63b5f5f2b0af2c1ae03b8"> </div> <div class="action-panel-control-wrap"><label for="email-to" class="action-panel-label required-field-asterisk"> To: </label> <input type="email" aria-label="Recipient Email Address" placeholder="email@example.com" id="email-to" class="email-to" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="100" required> </div> <div class="action-panel-control-wrap"><label for="email-from" class="action-panel-label"> From: </label> <input type="email" aria-label="Sender Email Address" placeholder="email@example.com" id="email-from" class="email-from" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="256"> </div> <div class="action-panel-control-wrap"><label for="email-citation-format" class="action-panel-label"> Format: </label> <select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format"> <option selected value="summary">Summary</option> <option value="summary-text">Summary (text)</option> <option value="abstract">Abstract</option> <option value="abstract-text">Abstract (text)</option> </select> </div> <div class="include-supplemental-container"><input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental"> <label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label> </div> <div class="form-field recaptcha "> <div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div> </div> <div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div> <div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="email" data-ga-label="send"> Send email </button> <button class="action-panel-cancel" aria-label="Close 'Email citations' panel" ref="linksrc=close_email_panel" aria-controls="email-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="email" data-ga-label="cancel"> Cancel </button> </div><input type="hidden" name="email-search-details" value=""> <input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524"> </form> </div> </div> <div id="collections-action-panel" class="collections-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-collections-open-panel-enabled="false" data-collections-open-panel-url-hash="#open-collections-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading">Add to Collections</h3> <form id="collections-action-panel-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/" data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-myncbi-max-collection-name-length="100" data-add-to-collection-max-amount="1000" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="KkshdUMOVQpqpQU71Jhk48QGE1IkNvi8HSnUKjODnKCBz0EKeuoCkhW8RJCRgxWX"> <div class="choice-group" role="radiogroup"> <ul class="radio-group-items"> <li><input type="radio" id="collections-action-panel-new" class="collections-new" name="collections" value="new" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_new"> <label for="collections-action-panel-new">Create a new collection</label></li> <li><input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label></li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading">Add to My Bibliography</h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"><input type="hidden" name="csrfmiddlewaretoken" value="KkshdUMOVQpqpQU71Jhk48QGE1IkNvi8HSnUKjODnKCBz0EKeuoCkhW8RJCRgxWX"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li><input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked> <label for="my-bibliography">My Bibliography</label></li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br><a href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#">Please try again</a> </div> <div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading">Your saved search</h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"><input type="hidden" name="csrfmiddlewaretoken" value="KkshdUMOVQpqpQU71Jhk48QGE1IkNvi8HSnUKjODnKCBz0EKeuoCkhW8RJCRgxWX"> <div class="action-panel-control-wrap"><label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"><label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"><a href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"><span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"><legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li><input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label></li> <li><input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label></li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"><label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://translate.google.com/website?sl=auto&tl=en&hl=auto&u=https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"><label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"><label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"><label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"><label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"><label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div><input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"><label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading">Create a file for external citation management software</h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"><input type="hidden" name="csrfmiddlewaretoken" value="KkshdUMOVQpqpQU71Jhk48QGE1IkNvi8HSnUKjODnKCBz0EKeuoCkhW8RJCRgxWX"> <input name="results-format" type="hidden" value="pubmed"> <div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading">Your RSS Feed</h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""><input type="hidden" name="csrfmiddlewaretoken" value="KkshdUMOVQpqpQU71Jhk48QGE1IkNvi8HSnUKjODnKCBz0EKeuoCkhW8RJCRgxWX"> <div class="action-panel-control-wrap"><label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"><label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected>15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"><label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="30500180"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title">Full text links</h3> <div class="full-text-links-list"><a class="link-item dialog-focus" href="https://translate.google.com/website?sl=auto&tl=en&hl=auto&u=https://doi.org/10.1021/acs.biochem.8b01074" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=3001&itool=Abstract-def&log$=linkouticon&uid=30500180&db=pubmed&nlmid=0370623" title="See full text options at American Chemical Society" data-ga-category="full_text" data-ga-action="American Chemical Society" data-ga-label="30500180"><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg" alt="full text provider logo"><span class="text"> American Chemical Society </span></a> </div> </div> <div class="short-view"><a href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#" class="full-text-links-button full-text-links-dialog-trigger"> Full text links </a> </div> </div> <div class="actions-buttons sidebar"> <h3 class="title">Actions</h3> <div class="inner-wrap"> <button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/30500180/citations/" data-citation-style="nlm" data-pubmed-format-link="/30500180/export/"><span class="button-label">Cite</span></button> <link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"> <div class="collections-button-container" data-article-id="30500180" data-article-db="pubmed"> <button class="collections-button collections-dialog-trigger" aria-label="Save article in MyNCBI collections." data-ga-category="collections_button" data-ga-action="click" 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</span><span class="cit">2018 Dec 26;57(51):6984-6996.</span> </div><span class="citation-doi"> doi: 10.1021/acs.biochem.8b01074. </span> <span class="secondary-date"> Epub 2018 Dec 7. </span> </div> <h1 class="heading-title">Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties</h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"><span class="authors-list-item "><a class="full-name" href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/?term=Tramonti+A&cauthor_id=30500180&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Angela Tramonti">Angela Tramonti</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Istituto di Biologia e Patologia Molecolari , Consiglio Nazionale delle Ricerche , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" , Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/?term=Nardella+C&cauthor_id=30500180&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Caterina Nardella">Caterina Nardella</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" , Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/?term=di+Salvo+ML&cauthor_id=30500180&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Martino L di Salvo">Martino L di Salvo</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" , Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/?term=Barile+A&cauthor_id=30500180&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Anna Barile">Anna Barile</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" , Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/?term=Cutruzzol%C3%A0+F&cauthor_id=30500180&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Francesca Cutruzzolà">Francesca Cutruzzolà</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" , Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/?term=Contestabile+R&cauthor_id=30500180&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Roberto Contestabile">Roberto Contestabile</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" , Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/30500180/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title">Affiliations</h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1"><sup class="key">1</sup> Istituto di Biologia e Patologia Molecolari , Consiglio Nazionale delle Ricerche , Piazzale Aldo Moro 5 , 00185 Roma , Italy.</li> <li data-affiliation-id="full-view-affiliation-2" id="full-view-affiliation-2"><sup class="key">2</sup> Dipartimento di Scienze Biochimiche "A. 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Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties</h1> <div class="short-citation"><span class="authors-list"> <span class="authors-list-item "><span class="full-name">Angela Tramonti</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> Biochemistry<span class="citation-separator">.</span> </span> <span class="date"> <time class="citation-year" datetime="2018">2018</time><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"><button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/30500180/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div class="display-options" data-format-key="format" 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id="short-view-expanded-authors"> <div class="authors"> <h3 class="title">Authors</h3> <div class="authors-list"><span class="authors-list-item "><a class="full-name" href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/?term=Tramonti+A&cauthor_id=30500180&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Angela Tramonti">Angela Tramonti</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Istituto di Biologia e Patologia Molecolari , Consiglio Nazionale delle Ricerche , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" , Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/?term=Nardella+C&cauthor_id=30500180&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Caterina Nardella">Caterina Nardella</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" , Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/?term=di+Salvo+ML&cauthor_id=30500180&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Martino L di Salvo">Martino L di Salvo</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" , Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/?term=Barile+A&cauthor_id=30500180&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Anna Barile">Anna Barile</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" , Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/?term=Cutruzzol%C3%A0+F&cauthor_id=30500180&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Francesca Cutruzzolà">Francesca Cutruzzolà</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" , Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/?term=Contestabile+R&cauthor_id=30500180&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Roberto Contestabile">Roberto Contestabile</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" , Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti , Piazzale Aldo Moro 5 , 00185 Roma , Italy." href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/30500180/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup></span> </div> </div> <div class="affiliations"> <h3 class="title">Affiliations</h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1"><sup class="key">1</sup> Istituto di Biologia e Patologia Molecolari , Consiglio Nazionale delle Ricerche , Piazzale Aldo Moro 5 , 00185 Roma , Italy.</li> <li data-affiliation-id="short-view-affiliation-2" id="short-view-affiliation-2"><sup class="key">2</sup> Dipartimento di Scienze Biochimiche "A. Rossi Fanelli" , Sapienza Università di Roma, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti , Piazzale Aldo Moro 5 , 00185 Roma , Italy.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li><span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">30500180</strong> </span></li> <li><span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1021/acs.biochem.8b01074&id_type=DOI" href="https://translate.google.com/website?sl=auto&tl=en&hl=auto&u=https://doi.org/10.1021/acs.biochem.8b01074" data-ga-category="full_text" data-ga-action="DOI"> 10.1021/acs.biochem.8b01074 </a> </span></li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"> <div class="inner-wrap"> <button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/30500180/citations/" data-citation-style="nlm" data-pubmed-format-link="/30500180/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button> <div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"> <button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button> <div class="dropdown" hidden> <div class="title"> Display options </div> <div class="content"> <div class="format-container"> <span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select> </div> </div> </div> </div> </div> </div> <div class="abstract" id="abstract"> <h2 class="title">Abstract</h2> <div class="abstract-content selected" id="eng-abstract"> <p>Serine hydroxymethyltransferase (SHMT) catalyzes the reversible conversion of l-serine and tetrahydrofolate into glycine and 5,10-methylenetetrahydrofolate. This enzyme, which plays a pivotal role in one-carbon metabolism, is involved in cancer metabolic reprogramming and is a recognized target of chemotherapy intervention. In humans, two isoforms of the enzyme exist, which are commonly termed cytosolic SHMT1 and mitochondrial SHMT2. Considerable attention has been paid to the structural, mechanistic, and metabolic features of these isozymes. On the other hand, a detailed comparison of their catalytic and regulatory properties is missing, although this aspect seems to be considerably important, considering that SHMT1 and SHMT2 reside in different cellular compartments, where they play distinct roles in folate metabolism. Here we performed a full kinetic characterization of the serine hydroxymethyltransferase reaction catalyzed by SHMT1 and SHMT2, with a focus on pH dependence and substrate inhibition. Our investigation, which allowed the determination of all kinetic parameters of serine hydroxymethyltransferase forward and backward reactions, uncovered a previously unobserved substrate inhibition by l-serine and highlighted several interesting differences between SHMT1 and SHMT2. In particular, SHMT2 maintains a pronounced tetrahydrofolate substrate inhibition even at the alkaline pH characteristic of the mitochondrial matrix, whereas with SHMT1 this is almost abolished. At this pH, SHMT2 also shows a catalytic efficiency that is much higher than that of SHMT1. These observations suggest that such different properties represent an adaptation of the isoforms to the respective cellular environments and that substrate inhibition may be a form of regulation.</p> </div> </div> <p class="disclaimer" id="disclaimer"><a href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/disclaimer/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a></p> <div class="similar-articles" id="similar"> <h2 class="title">Similar articles</h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"><a class="docsum-title" href="https://pubmed-ncbi-nlm-nih-gov.translate.goog/27530298/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=auto" ref="article_id=27530298&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="27530298" data-ga-label=""> Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming. </a> <div class="docsum-citation full-citation"><span class="docsum-authors full-authors">Paiardini A, Tramonti A, Schirch D, Guiducci G, di Salvo ML, Fiascarelli A, Giorgi A, Maras B, Cutruzzolà F, Contestabile R.</span> <span class="docsum-authors short-authors">Paiardini A, et al.</span> <span class="docsum-journal-citation full-journal-citation">Biochim Biophys Acta. 2016 Nov;1864(11):1506-17. doi: 10.1016/j.bbapap.2016.08.010. 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