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aria-live="polite">Scholarly Works (7 results)</h2></header><div class="c-sortpagination"><div class="c-sort"><div class="o-input__droplist1"><label for="c-sort1">Sort By:</label><select name="sort" id="c-sort1" form="facetForm"><option selected="" value="rel">Relevance</option><option value="a-title">A-Z By Title</option><option value="z-title">Z-A By Title</option><option value="a-author">A-Z By Author</option><option value="z-author">Z-A By Author</option><option value="asc">Date Ascending</option><option value="desc">Date Descending</option></select></div></div><input type="hidden" name="start" form="facetForm" value="0"/></div><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/7g35z6jm"><div class="c-clientmarkup">Trevo 3 Mm and/or AXS Catalyst 5 for the Treatment of Medium Distal Vessel Occlusion Stroke-results from the ASSIST Registry.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ANtoulias%2C%20Nikolaos">Ntoulias, Nikolaos</a>; </li><li><a href="/search/?q=author%3ABrehm%2C%20Alex">Brehm, Alex</a>; </li><li><a href="/search/?q=author%3AMiralb%C3%A9s%2C%20Salvador">Miralbés, Salvador</a>; </li><li><a href="/search/?q=author%3ANaravetla%2C%20Bharath">Naravetla, Bharath</a>; </li><li><a href="/search/?q=author%3ASpiotta%2C%20Alejandro">Spiotta, Alejandro</a>; </li><li><a href="/search/?q=author%3ALoehr%2C%20Christian">Loehr, Christian</a>; </li><li><a href="/search/?q=author%3AMart%C3%ADnez-Gald%C3%A1mez%2C%20Mario">Martínez-Galdámez, Mario</a>; </li><li><a href="/search/?q=author%3AMcTaggart%2C%20Ryan">McTaggart, Ryan</a>; </li><li><a href="/search/?q=author%3ADefreyne%2C%20Luc">Defreyne, Luc</a>; </li><li><a href="/search/?q=author%3AVega%2C%20Pedro">Vega, Pedro</a>; </li><li><a href="/search/?q=author%3AZaidat%2C%20Osama">Zaidat, Osama</a>; </li><li><a href="/search/?q=author%3APrice%2C%20Lori">Price, Lori</a>; </li><li><a href="/search/?q=author%3ALiebeskind%2C%20David">Liebeskind, David</a>; </li><li><a href="/search/?q=author%3AM%C3%B6hlenbruch%2C%20Markus">Möhlenbruch, Markus</a>; </li><li><a href="/search/?q=author%3AGupta%2C%20Rishi">Gupta, Rishi</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3APsychogios%2C%20Marios-Nikos">Psychogios, Marios-Nikos</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2025)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">BACKGROUND: The effect of endovascular therapy (EVT) on the outcome of stroke patients with a medium distal vessel occlusion (MDVO) is unclear. We report the results of MDVO patients treated with the 3 mm Trevo stent retriever (SR) and/or the AXS Catalyst 5 distal access catheter. METHODS: Data was derived from a prospective, multicenter global registry (ASSIST registry) which enrolled patients treated with operator preferred EVT technique at 71 sites from January 2019 to January 2022. Three techniques were assessed: SR classic, direct aspiration, and a combined approach. Additional inclusion criteria were (a) EVT performed with the 3 mm Trevo SR and/or AXS Catalyst 5 distal access catheter on the first pass and (b) an occlusion of the M2 segment or M3 segment of the middle cerebral artery or the A1, A2 or A3 segment of the anterior cerebral artery. The primary outcome was achieving an expanded Thrombolysis in Cerebral Infarction (eTICI) score of 2c or 3 on the first pass, with the primary technique as adjudicated by core lab. The primary clinical outcome measure was a 90-day modified Rankin Scale (mRS) score of 0-2. RESULTS: A total of 155 patients (10.4% of the ASSIST population) were included. Most patients had an M2 occlusion (93.5%). First pass eTICI reperfusion was achieved in 43.1% of the patients. No modifying effect of the frontline technique was found. The rate of mRS 0-2 (overall 65.0%) did not significantly differ between groups. CONCLUSION: The data suggests that the Trevo 3 mm SR and/or the AXS Catalyst 5 may be an option to treat medium distal vessel occlusion, but more data is needed to demonstrate safety and efficacy in this patient cohort. Further improvements are needed regarding materials and techniques to improve reperfusion results in this patient cohort in the future.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/7g35z6jm"><img src="/cms-assets/3d4ff6c21758ab81de3a2289556bbbd6699b453f277b3915da9cc80de4105a9f" alt="Cover page: Trevo 3 Mm and/or AXS Catalyst&nbsp;5 for the Treatment of Medium Distal Vessel Occlusion Stroke-results from the ASSIST Registry."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/25b9t91j"><div class="c-clientmarkup">Outcomes of mechanical thrombectomy in anticoagulated patients with acute distal and medium vessel stroke.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ASalim%2C%20Hamza">Salim, Hamza</a>; </li><li><a href="/search/?q=author%3AMusmar%2C%20Basel">Musmar, Basel</a>; </li><li><a href="/search/?q=author%3AAdeeb%2C%20Nimer">Adeeb, Nimer</a>; </li><li><a href="/search/?q=author%3AYedavalli%2C%20Vivek">Yedavalli, Vivek</a>; </li><li><a href="/search/?q=author%3ALakhani%2C%20Dhairya">Lakhani, Dhairya</a>; </li><li><a href="/search/?q=author%3AGrewal%2C%20Sahibjot">Grewal, Sahibjot</a>; </li><li><a href="/search/?q=author%3AEl%20Naamani%2C%20Kareem">El Naamani, Kareem</a>; </li><li><a href="/search/?q=author%3AHenninger%2C%20Nils">Henninger, Nils</a>; </li><li><a href="/search/?q=author%3ASundararajan%2C%20Sri">Sundararajan, Sri</a>; </li><li><a href="/search/?q=author%3AK%C3%BChn%2C%20Anna">Kühn, Anna</a>; </li><li><a href="/search/?q=author%3AKhalife%2C%20Jane">Khalife, Jane</a>; </li><li><a href="/search/?q=author%3AGhozy%2C%20Sherief">Ghozy, Sherief</a>; </li><li><a href="/search/?q=author%3AScarcia%2C%20Luca">Scarcia, Luca</a>; </li><li><a href="/search/?q=author%3ATan%2C%20Benjamin">Tan, Benjamin</a>; </li><li><a href="/search/?q=author%3ARegenhardt%2C%20Robert">Regenhardt, Robert</a>; </li><li><a href="/search/?q=author%3AHeit%2C%20Jeremy">Heit, Jeremy</a>; </li><li><a href="/search/?q=author%3ACancelliere%2C%20Nicole">Cancelliere, Nicole</a>; </li><li><a href="/search/?q=author%3ABernstock%2C%20Joshua">Bernstock, Joshua</a>; </li><li><a href="/search/?q=author%3ARouchaud%2C%20Aymeric">Rouchaud, Aymeric</a>; </li><li><a href="/search/?q=author%3AFiehler%2C%20Jens">Fiehler, Jens</a>; </li><li><a href="/search/?q=author%3ASheth%2C%20Sunil">Sheth, Sunil</a>; </li><li><a href="/search/?q=author%3APuri%2C%20Ajit">Puri, Ajit</a>; </li><li><a href="/search/?q=author%3ADyzmann%2C%20Christian">Dyzmann, Christian</a>; </li><li><a href="/search/?q=author%3AColasurdo%2C%20Marco">Colasurdo, Marco</a>; </li><li><a href="/search/?q=author%3ABarreau%2C%20Xavier">Barreau, Xavier</a>; </li><li><a href="/search/?q=author%3ARenieri%2C%20Leonardo">Renieri, Leonardo</a>; </li><li><a href="/search/?q=author%3AFilipe%2C%20Jo%C3%A3o">Filipe, João</a>; </li><li><a href="/search/?q=author%3AHarker%2C%20Pablo">Harker, Pablo</a>; </li><li><a href="/search/?q=author%3ARadu%2C%20R%C4%83zvan">Radu, Răzvan</a>; </li><li><a href="/search/?q=author%3AAbdalkader%2C%20Mohamad">Abdalkader, Mohamad</a>; </li><li><a href="/search/?q=author%3AKlein%2C%20Piers">Klein, Piers</a>; </li><li><a href="/search/?q=author%3AMarotta%2C%20Thomas">Marotta, Thomas</a>; </li><li><a href="/search/?q=author%3ASpears%2C%20Julian">Spears, Julian</a>; </li><li><a href="/search/?q=author%3AOta%2C%20Takahiro">Ota, Takahiro</a>; </li><li><a href="/search/?q=author%3AMowla%2C%20Ashkan">Mowla, Ashkan</a>; </li><li><a href="/search/?q=author%3AJabbour%2C%20Pascal">Jabbour, Pascal</a>; </li><li><a href="/search/?q=author%3ABiswas%2C%20Arundhati">Biswas, Arundhati</a>; </li><li><a href="/search/?q=author%3AClaren%C3%A7on%2C%20Fr%C3%A9d%C3%A9ric">Clarençon, Frédéric</a>; </li><li><a href="/search/?q=author%3ASiegler%2C%20James">Siegler, James</a>; </li><li><a href="/search/?q=author%3ANguyen%2C%20Thanh">Nguyen, Thanh</a>; </li><li><a href="/search/?q=author%3AVarela%2C%20Ricardo">Varela, Ricardo</a>; </li><li><a href="/search/?q=author%3ABaker%2C%20Amanda">Baker, Amanda</a>; </li><li><a href="/search/?q=author%3AEssibayi%2C%20Muhammed">Essibayi, Muhammed</a>; </li><li><a href="/search/?q=author%3AAltschul%2C%20David">Altschul, David</a>; </li><li><a href="/search/?q=author%3AGonzalez%2C%20Nestor">Gonzalez, Nestor</a>; </li><li><a href="/search/?q=author%3AM%C3%B6hlenbruch%2C%20Markus">Möhlenbruch, Markus</a>; </li><li><a href="/search/?q=author%3ACostalat%2C%20Vincent">Costalat, Vincent</a>; </li><li><a href="/search/?q=author%3AGory%2C%20Benjamin">Gory, Benjamin</a>; </li><li><a href="/search/?q=author%3AStracke%2C%20Christian">Stracke, Christian</a>; </li><li><a href="/search/?q=author%3AAziz-Sultan%2C%20Mohammad">Aziz-Sultan, Mohammad</a>; </li><li><a href="/search/?q=author%3AHecker%2C%20Constantin">Hecker, Constantin</a>; </li><li><a href="/search/?q=author%3AShaikh%2C%20Hamza">Shaikh, Hamza</a>; </li><li><a href="/search/?q=author%3ALiebeskind%2C%20David">Liebeskind, David</a>; </li><li><a href="/search/?q=author%3APedicelli%2C%20Alessandro">Pedicelli, Alessandro</a>; </li><li><a href="/search/?q=author%3AAlexandre%2C%20Andrea">Alexandre, Andrea</a>; </li><li><a href="/search/?q=author%3ATancredi%2C%20Illario">Tancredi, Illario</a>; </li><li><a href="/search/?q=author%3AFaizy%2C%20Tobias">Faizy, Tobias</a>; </li><li><a href="/search/?q=author%3AKalsoum%2C%20Erwah">Kalsoum, Erwah</a>; </li><li><a href="/search/?q=author%3ALubicz%2C%20Boris">Lubicz, Boris</a>; </li><li><a href="/search/?q=author%3APatel%2C%20Aman">Patel, Aman</a>; </li><li><a href="/search/?q=author%3APereira%2C%20Vitor">Pereira, Vitor</a>; </li><li><a href="/search/?q=author%3AGuenego%2C%20Adrien">Guenego, Adrien</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ADmytriw%2C%20Adam">Dmytriw, Adam</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2024)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">BACKGROUND: Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients with distal medium vessel occlusions (DMVO) are not well understood. METHODS: This retrospective analysis involved 1282 acute ischemic stroke (AIS) patients who underwent MT in 37 centers across North America, Asia, and Europe from September 2017 to July 2023. Data on demographics, clinical presentation, treatment specifics, and outcomes were collected. The primary outcomes were functional outcomes at 90 days post-MT, measured by modified Rankin Scale (mRS) scores. Secondary outcomes included reperfusion rates, mortality, and hemorrhagic complications. RESULTS: Of the patients, 223 (34%) were on anticoagulation therapy. Anticoagulated patients were older (median age 78 vs 74 years; p < 0.001) and had a higher prevalence of atrial fibrillation (77% vs 26%; p < 0.001). Their baseline National Institutes of Health Stroke Scale (NIHSS) scores were also higher (median 12 vs 9; p = 0.002). Before propensity score matching (PSM), anticoagulated patients had similar rates of favorable 90-day outcomes (mRS 0-1: 30% vs 37%, p = 0.1; mRS 0-2: 47% vs 50%, p = 0.41) but higher mortality (26% vs 17%, p = 0.008). After PSM, there were no significant differences in outcomes between the two groups. CONCLUSION: Anticoagulated patients undergoing MT for AIS due to DMVO did not show significant differences in 90-day mRS outcomes, reperfusion, or hemorrhage compared to non-anticoagulated patients after adjustment for covariates.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/25b9t91j"><img src="/cms-assets/f03ee50773afbd1b41a0b80604487d4510a6bd4797c30da7ed201fb7d17cb7d9" alt="Cover page: Outcomes of mechanical thrombectomy in anticoagulated patients with acute distal and medium vessel stroke."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/2nv5s326"><div class="c-clientmarkup">Endovascular therapy versus medical management in isolated posterior cerebral artery acute ischemic stroke: A multinational multicenter propensity score-weighted study.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ASalim%2C%20Hamza">Salim, Hamza</a>; </li><li><a href="/search/?q=author%3APulli%2C%20Benjamin">Pulli, Benjamin</a>; </li><li><a href="/search/?q=author%3AYedavalli%2C%20Vivek">Yedavalli, Vivek</a>; </li><li><a href="/search/?q=author%3AMusmar%2C%20Basel">Musmar, Basel</a>; </li><li><a href="/search/?q=author%3AAdeeb%2C%20Nimer">Adeeb, Nimer</a>; </li><li><a href="/search/?q=author%3ALakhani%2C%20Dhairya">Lakhani, Dhairya</a>; </li><li><a href="/search/?q=author%3AEssibayi%2C%20Muhammed">Essibayi, Muhammed</a>; </li><li><a href="/search/?q=author%3AEl%20Naamani%2C%20Kareem">El Naamani, Kareem</a>; </li><li><a href="/search/?q=author%3AHenninger%2C%20Nils">Henninger, Nils</a>; </li><li><a href="/search/?q=author%3ASundararajan%2C%20Sri">Sundararajan, Sri</a>; </li><li><a href="/search/?q=author%3AK%C3%BChn%2C%20Anna">Kühn, Anna</a>; </li><li><a href="/search/?q=author%3AKhalife%2C%20Jane">Khalife, Jane</a>; </li><li><a href="/search/?q=author%3AGhozy%2C%20Sherief">Ghozy, Sherief</a>; </li><li><a href="/search/?q=author%3AScarcia%2C%20Luca">Scarcia, Luca</a>; </li><li><a href="/search/?q=author%3AGrewal%2C%20Inayat">Grewal, Inayat</a>; </li><li><a href="/search/?q=author%3ATan%2C%20Benjamin">Tan, Benjamin</a>; </li><li><a href="/search/?q=author%3ARegenhardt%2C%20Robert">Regenhardt, Robert</a>; </li><li><a href="/search/?q=author%3AHeit%2C%20Jeremy">Heit, Jeremy</a>; </li><li><a href="/search/?q=author%3ACancelliere%2C%20Nicole">Cancelliere, Nicole</a>; </li><li><a href="/search/?q=author%3ABernstock%2C%20Joshua">Bernstock, Joshua</a>; </li><li><a href="/search/?q=author%3ARouchaud%2C%20Aymeric">Rouchaud, Aymeric</a>; </li><li><a href="/search/?q=author%3AFiehler%2C%20Jens">Fiehler, Jens</a>; </li><li><a href="/search/?q=author%3ASheth%2C%20Sunil">Sheth, Sunil</a>; </li><li><a href="/search/?q=author%3APuri%2C%20Ajit">Puri, Ajit</a>; </li><li><a href="/search/?q=author%3ADyzmann%2C%20Christian">Dyzmann, Christian</a>; </li><li><a href="/search/?q=author%3AColasurdo%2C%20Marco">Colasurdo, Marco</a>; </li><li><a href="/search/?q=author%3ABarreau%2C%20Xavier">Barreau, Xavier</a>; </li><li><a href="/search/?q=author%3ARenieri%2C%20Leonardo">Renieri, Leonardo</a>; </li><li><a href="/search/?q=author%3AFilipe%2C%20Jo%C3%A3o">Filipe, João</a>; </li><li><a href="/search/?q=author%3AHarker%2C%20Pablo">Harker, Pablo</a>; </li><li><a href="/search/?q=author%3ARadu%2C%20R%C4%83zvan">Radu, Răzvan</a>; </li><li><a href="/search/?q=author%3AAbdalkader%2C%20Mohamad">Abdalkader, Mohamad</a>; </li><li><a href="/search/?q=author%3AKlein%2C%20Piers">Klein, Piers</a>; </li><li><a href="/search/?q=author%3AMarotta%2C%20Thomas">Marotta, Thomas</a>; </li><li><a href="/search/?q=author%3ASpears%2C%20Julian">Spears, Julian</a>; </li><li><a href="/search/?q=author%3AOta%2C%20Takahiro">Ota, Takahiro</a>; </li><li><a href="/search/?q=author%3AMowla%2C%20Ashkan">Mowla, Ashkan</a>; </li><li><a href="/search/?q=author%3AJabbour%2C%20Pascal">Jabbour, Pascal</a>; </li><li><a href="/search/?q=author%3ABiswas%2C%20Arundhati">Biswas, Arundhati</a>; </li><li><a href="/search/?q=author%3AClaren%C3%A7on%2C%20Fr%C3%A9d%C3%A9ric">Clarençon, Frédéric</a>; </li><li><a href="/search/?q=author%3ASiegler%2C%20James">Siegler, James</a>; </li><li><a href="/search/?q=author%3ANguyen%2C%20Thanh">Nguyen, Thanh</a>; </li><li><a href="/search/?q=author%3AVarela%2C%20Ricardo">Varela, Ricardo</a>; </li><li><a href="/search/?q=author%3ABaker%2C%20Amanda">Baker, Amanda</a>; </li><li><a href="/search/?q=author%3AAltschul%2C%20David">Altschul, David</a>; </li><li><a href="/search/?q=author%3AGonzalez%2C%20Nestor">Gonzalez, Nestor</a>; </li><li><a href="/search/?q=author%3AM%C3%B6hlenbruch%2C%20Markus">Möhlenbruch, Markus</a>; </li><li><a href="/search/?q=author%3ACostalat%2C%20Vincent">Costalat, Vincent</a>; </li><li><a href="/search/?q=author%3AGory%2C%20Benjamin">Gory, Benjamin</a>; </li><li><a href="/search/?q=author%3AStracke%2C%20Christian">Stracke, Christian</a>; </li><li><a href="/search/?q=author%3AAziz-Sultan%2C%20Mohammad">Aziz-Sultan, Mohammad</a>; </li><li><a href="/search/?q=author%3AHecker%2C%20Constantin">Hecker, Constantin</a>; </li><li><a href="/search/?q=author%3AShaikh%2C%20Hamza">Shaikh, Hamza</a>; </li><li><a href="/search/?q=author%3AGriessenauer%2C%20Christoph">Griessenauer, Christoph</a>; </li><li><a href="/search/?q=author%3ALiebeskind%2C%20David">Liebeskind, David</a>; </li><li><a href="/search/?q=author%3APedicelli%2C%20Alessandro">Pedicelli, Alessandro</a>; </li><li><a href="/search/?q=author%3AAlexandre%2C%20Andrea">Alexandre, Andrea</a>; </li><li><a href="/search/?q=author%3ATancredi%2C%20Illario">Tancredi, Illario</a>; </li><li><a href="/search/?q=author%3AFaizy%2C%20Tobias">Faizy, Tobias</a>; </li><li><a href="/search/?q=author%3AKalsoum%2C%20Erwah">Kalsoum, Erwah</a>; </li><li><a href="/search/?q=author%3ALubicz%2C%20Boris">Lubicz, Boris</a>; </li><li><a href="/search/?q=author%3APatel%2C%20Aman">Patel, Aman</a>; </li><li><a href="/search/?q=author%3APereira%2C%20Vitor">Pereira, Vitor</a>; </li><li><a href="/search/?q=author%3AWintermark%2C%20Max">Wintermark, Max</a>; </li><li><a href="/search/?q=author%3AGuenego%2C%20Adrien">Guenego, Adrien</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ADmytriw%2C%20Adam">Dmytriw, Adam</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2024)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">BACKGROUND: Despite the proven effectiveness of endovascular therapy (EVT) in acute ischemic strokes (AIS) involving anterior circulation large vessel occlusions, isolated posterior cerebral artery (PCA) occlusions (iPCAo) remain underexplored in clinical trials. This study investigates the comparative effectiveness and safety of EVT against medical management (MM) in patients with iPCAo. METHODS: This multinational, multicenter propensity score-weighted study analyzed data from the Multicenter Analysis of primary Distal medium vessel occlusions: effect of Mechanical Thrombectomy (MAD-MT) registry, involving 37 centers across North America, Asia, and Europe. We included iPCAo patients treated with either EVT or MM. The primary outcome was the modified Rankin Scale (mRS) at 90 days, with secondary outcomes including functional independence, mortality, and safety profiles such as hemorrhagic complications. RESULTS: A total of 177 patients were analyzed (88 MM and 89 EVT). EVT showed a statistically significant improvement in 90-day mRS scores (OR = 0.55, 95% CI = 0.30-1.00, p = 0.048), functional independence (OR = 2.52, 95% CI = 1.02-6.20, p = 0.045), and a reduction in 90-day mortality (OR = 0.12, 95% CI = 0.03-0.54, p = 0.006) compared to MM. Hemorrhagic complications were not significantly different between the groups. CONCLUSION: EVT for iPCAo is associated with better neurological outcomes and lower mortality compared to MM, without an increased risk of hemorrhagic complications. Nevertheless, these results should be interpreted with caution due to the studys observational design. The findings are hypothesis-generating and highlight the need for future randomized controlled trials to confirm these observations and establish definitive treatment guidelines for this patient population.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/2nv5s326"><img src="/cms-assets/76a222eb9c11cdb407b8642200da531db0f350bcfa6c6418cd54dde307204069" alt="Cover page: Endovascular therapy versus medical management in isolated posterior cerebral artery acute ischemic stroke: A multinational multicenter propensity score-weighted study."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/08c0t7f8"><div class="c-clientmarkup">Predictive value of follow-up infarct volume on functional outcomes in middle cerebral artery M2 segment vessel occlusion stroke treated with mechanical thrombectomy.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3AYedavalli%2C%20Vivek">Yedavalli, Vivek</a>; </li><li><a href="/search/?q=author%3ASalim%2C%20Hamza">Salim, Hamza</a>; </li><li><a href="/search/?q=author%3AMusmar%2C%20Basel">Musmar, Basel</a>; </li><li><a href="/search/?q=author%3AAdeeb%2C%20Nimer">Adeeb, Nimer</a>; </li><li><a href="/search/?q=author%3AEl%20Naamani%2C%20Kareem">El Naamani, Kareem</a>; </li><li><a href="/search/?q=author%3AHenninger%2C%20Nils">Henninger, Nils</a>; </li><li><a href="/search/?q=author%3ASundararajan%2C%20Sri">Sundararajan, Sri</a>; </li><li><a href="/search/?q=author%3AK%C3%BChn%2C%20Anna">Kühn, Anna</a>; </li><li><a href="/search/?q=author%3AKhalife%2C%20Jane">Khalife, Jane</a>; </li><li><a href="/search/?q=author%3AGhozy%2C%20Sherief">Ghozy, Sherief</a>; </li><li><a href="/search/?q=author%3AScarcia%2C%20Luca">Scarcia, Luca</a>; </li><li><a href="/search/?q=author%3ATan%2C%20Benjamin">Tan, Benjamin</a>; </li><li><a href="/search/?q=author%3ARegenhardt%2C%20Robert">Regenhardt, Robert</a>; </li><li><a href="/search/?q=author%3AHeit%2C%20Jeremy">Heit, Jeremy</a>; </li><li><a href="/search/?q=author%3ACancelliere%2C%20Nicole">Cancelliere, Nicole</a>; </li><li><a href="/search/?q=author%3ABernstock%2C%20Joshua">Bernstock, Joshua</a>; </li><li><a href="/search/?q=author%3ARouchaud%2C%20Aymeric">Rouchaud, Aymeric</a>; </li><li><a href="/search/?q=author%3AFiehler%2C%20Jens">Fiehler, Jens</a>; </li><li><a href="/search/?q=author%3ASheth%2C%20Sunil">Sheth, Sunil</a>; </li><li><a href="/search/?q=author%3APuri%2C%20Ajit">Puri, Ajit</a>; </li><li><a href="/search/?q=author%3ADyzmann%2C%20Christian">Dyzmann, Christian</a>; </li><li><a href="/search/?q=author%3AColasurdo%2C%20Marco">Colasurdo, Marco</a>; </li><li><a href="/search/?q=author%3ABarreau%2C%20Xavier">Barreau, Xavier</a>; </li><li><a href="/search/?q=author%3ARenieri%2C%20Leonardo">Renieri, Leonardo</a>; </li><li><a href="/search/?q=author%3AFilipe%2C%20Jo%C3%A3o">Filipe, João</a>; </li><li><a href="/search/?q=author%3AHarker%2C%20Pablo">Harker, Pablo</a>; </li><li><a href="/search/?q=author%3ARadu%2C%20R%C4%83zvan">Radu, Răzvan</a>; </li><li><a href="/search/?q=author%3AAbdalkader%2C%20Mohamad">Abdalkader, Mohamad</a>; </li><li><a href="/search/?q=author%3AKlein%2C%20Piers">Klein, Piers</a>; </li><li><a href="/search/?q=author%3AMarotta%2C%20Thomas">Marotta, Thomas</a>; </li><li><a href="/search/?q=author%3ASpears%2C%20Julian">Spears, Julian</a>; </li><li><a href="/search/?q=author%3AOta%2C%20Takahiro">Ota, Takahiro</a>; </li><li><a href="/search/?q=author%3AMowla%2C%20Ashkan">Mowla, Ashkan</a>; </li><li><a href="/search/?q=author%3AJabbour%2C%20Pascal">Jabbour, Pascal</a>; </li><li><a href="/search/?q=author%3ABiswas%2C%20Arundhati">Biswas, Arundhati</a>; </li><li><a href="/search/?q=author%3AClaren%C3%A7on%2C%20Fr%C3%A9d%C3%A9ric">Clarençon, Frédéric</a>; </li><li><a href="/search/?q=author%3ASiegler%2C%20James">Siegler, James</a>; </li><li><a href="/search/?q=author%3ANguyen%2C%20Thanh">Nguyen, Thanh</a>; </li><li><a href="/search/?q=author%3AVarela%2C%20Ricardo">Varela, Ricardo</a>; </li><li><a href="/search/?q=author%3ABaker%2C%20Amanda">Baker, Amanda</a>; </li><li><a href="/search/?q=author%3AEssibayi%2C%20Muhammed">Essibayi, Muhammed</a>; </li><li><a href="/search/?q=author%3AAltschul%2C%20David">Altschul, David</a>; </li><li><a href="/search/?q=author%3AGonzalez%2C%20Nestor">Gonzalez, Nestor</a>; </li><li><a href="/search/?q=author%3AM%C3%B6hlenbruch%2C%20Markus">Möhlenbruch, Markus</a>; </li><li><a href="/search/?q=author%3ACostalat%2C%20Vincent">Costalat, Vincent</a>; </li><li><a href="/search/?q=author%3AGory%2C%20Benjamin">Gory, Benjamin</a>; </li><li><a href="/search/?q=author%3AStracke%2C%20Christian">Stracke, Christian</a>; </li><li><a href="/search/?q=author%3AAziz-Sultan%2C%20Mohammad">Aziz-Sultan, Mohammad</a>; </li><li><a href="/search/?q=author%3AHecker%2C%20Constantin">Hecker, Constantin</a>; </li><li><a href="/search/?q=author%3AShaikh%2C%20Hamza">Shaikh, Hamza</a>; </li><li><a href="/search/?q=author%3ALiebeskind%2C%20David">Liebeskind, David</a>; </li><li><a href="/search/?q=author%3APedicelli%2C%20Alessandro">Pedicelli, Alessandro</a>; </li><li><a href="/search/?q=author%3AAlexandre%2C%20Andrea">Alexandre, Andrea</a>; </li><li><a href="/search/?q=author%3ATancredi%2C%20Illario">Tancredi, Illario</a>; </li><li><a href="/search/?q=author%3AFaizy%2C%20Tobias">Faizy, Tobias</a>; </li><li><a href="/search/?q=author%3AKalsoum%2C%20Erwah">Kalsoum, Erwah</a>; </li><li><a href="/search/?q=author%3ALubicz%2C%20Boris">Lubicz, Boris</a>; </li><li><a href="/search/?q=author%3APatel%2C%20Aman">Patel, Aman</a>; </li><li><a href="/search/?q=author%3APereira%2C%20Vitor">Pereira, Vitor</a>; </li><li><a href="/search/?q=author%3AGuenego%2C%20Adrien">Guenego, Adrien</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ADmytriw%2C%20Adam">Dmytriw, Adam</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2024)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">BACKGROUND: Medium vessel occlusion (MeVO) strokes, particularly affecting the M2 segment of the middle cerebral artery, represent a critical proportion of acute ischemic strokes, posing significant challenges in management and outcome prediction. The efficacy of mechanical thrombectomy (MT) in MeVO stroke may warrant reliable predictors of functional outcomes. This study aimed to investigate the prognostic value of follow-up infarct volume (FIV) for predicting 90-day functional outcomes in MeVO stroke patients undergoing MT. METHODS: This multicenter, retrospective cohort study analyzed data from the Multicenter Analysis of primary Distal medium vessel occlusions: effect of Mechanical Thrombectomy (MAD-MT) registry, covering patients with acute ischemic stroke due to M2 segment occlusion treated with MT. We examined the relationship between 90-day functional outcomes, measured by the modified Rankin Scale (mRS), and follow-up infarct volume (FIV), assessed through CT or MRI within 12-36 h post-MT. RESULTS: Among 130 participants, specific FIV thresholds were identified with high specificity and sensitivity for predicting outcomes. A FIV ⩽5 ml was highly specific for predicting favorable and excellent outcomes. The optimal cut-off for both prognostications was identified at ⩽15 ml by the Youden Index, with significant reductions in the likelihood of favorable outcomes observed above a 40 ml threshold. Receiver Operator Curve (ROC) analyses confirmed FIV as a superior predictor of functional outcomes compared to traditional recanalization scores, such as final modified thrombolysis in cerebral infarction score (mTICI). Multivariable analysis further highlighted the inverse relationship between FIV and positive functional outcomes. CONCLUSIONS: FIV within 36 h post-MT serves as a potent predictor of 90-day functional outcomes in patients with M2 segment MeVO strokes. Establishing FIV thresholds may aid in the prognostication of stroke outcomes, suggesting a role for FIV in guiding post intervention treatment decisions and informing clinical practice. Future research should focus on validating these findings across diverse patient populations and exploring the integration of FIV measurements with other clinical and imaging markers to enhance outcome prediction accuracy.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/08c0t7f8"><img src="/cms-assets/f04ee5f6bace8de3c1ac9d97bfcd28b485a33b2a153df6a489fb8cb24cd3fa06" alt="Cover page: Predictive value of follow-up infarct volume on functional outcomes in middle cerebral artery M2 segment vessel occlusion stroke treated with mechanical thrombectomy."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/6vj2189c"><div class="c-clientmarkup">First pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ARadu%2C%20R%C4%83zvan">Radu, Răzvan</a>; </li><li><a href="/search/?q=author%3ACostalat%2C%20Vincent">Costalat, Vincent</a>; </li><li><a href="/search/?q=author%3AFahed%2C%20Robert">Fahed, Robert</a>; </li><li><a href="/search/?q=author%3AGhozy%2C%20Sherief">Ghozy, Sherief</a>; </li><li><a href="/search/?q=author%3ASiegler%2C%20James">Siegler, James</a>; </li><li><a href="/search/?q=author%3AShaikh%2C%20Hamza">Shaikh, Hamza</a>; </li><li><a href="/search/?q=author%3AKhalife%2C%20Jane">Khalife, Jane</a>; </li><li><a href="/search/?q=author%3AAbdalkader%2C%20Mohamad">Abdalkader, Mohamad</a>; </li><li><a href="/search/?q=author%3AKlein%2C%20Piers">Klein, Piers</a>; </li><li><a href="/search/?q=author%3ANguyen%2C%20Thanh">Nguyen, Thanh</a>; </li><li><a href="/search/?q=author%3AHeit%2C%20Jeremy">Heit, Jeremy</a>; </li><li><a href="/search/?q=author%3ASweid%2C%20Ahmad">Sweid, Ahmad</a>; </li><li><a href="/search/?q=author%3AEl%20Naamani%2C%20Kareem">El Naamani, Kareem</a>; </li><li><a href="/search/?q=author%3ARegenhardt%2C%20Robert">Regenhardt, Robert</a>; </li><li><a href="/search/?q=author%3ADiestro%2C%20Jose">Diestro, Jose</a>; </li><li><a href="/search/?q=author%3ACancelliere%2C%20Nicole">Cancelliere, Nicole</a>; </li><li><a href="/search/?q=author%3AAmllay%2C%20Abdelaziz">Amllay, Abdelaziz</a>; </li><li><a href="/search/?q=author%3AMeyer%2C%20Lukas">Meyer, Lukas</a>; </li><li><a href="/search/?q=author%3ADusart%2C%20Anne">Dusart, Anne</a>; </li><li><a href="/search/?q=author%3ABellante%2C%20Flavio">Bellante, Flavio</a>; </li><li><a href="/search/?q=author%3AForestier%2C%20G%C3%A9raud">Forestier, Géraud</a>; </li><li><a href="/search/?q=author%3ARouchaud%2C%20Aymeric">Rouchaud, Aymeric</a>; </li><li><a href="/search/?q=author%3ASaleme%2C%20Suzana">Saleme, Suzana</a>; </li><li><a href="/search/?q=author%3AMounayer%2C%20Charbel">Mounayer, Charbel</a>; </li><li><a href="/search/?q=author%3AFiehler%2C%20Jens">Fiehler, Jens</a>; </li><li><a href="/search/?q=author%3AK%C3%BChn%2C%20Anna">Kühn, Anna</a>; </li><li><a href="/search/?q=author%3APuri%2C%20Ajit">Puri, Ajit</a>; </li><li><a href="/search/?q=author%3ADyzmann%2C%20Christian">Dyzmann, Christian</a>; </li><li><a href="/search/?q=author%3AKan%2C%20Peter">Kan, Peter</a>; </li><li><a href="/search/?q=author%3AColasurdo%2C%20Marco">Colasurdo, Marco</a>; </li><li><a href="/search/?q=author%3AMarnat%2C%20Gaultier">Marnat, Gaultier</a>; </li><li><a href="/search/?q=author%3ABerge%2C%20J%C3%A9r%C3%B4me">Berge, Jérôme</a>; </li><li><a href="/search/?q=author%3ABarreau%2C%20Xavier">Barreau, Xavier</a>; </li><li><a href="/search/?q=author%3ASibon%2C%20Igor">Sibon, Igor</a>; </li><li><a href="/search/?q=author%3ANedelcu%2C%20Simona">Nedelcu, Simona</a>; </li><li><a href="/search/?q=author%3AHenninger%2C%20Nils">Henninger, Nils</a>; </li><li><a href="/search/?q=author%3AKyheng%2C%20Ma%C3%A9va">Kyheng, Maéva</a>; </li><li><a href="/search/?q=author%3AMarotta%2C%20Thomas">Marotta, Thomas</a>; </li><li><a href="/search/?q=author%3AStapleton%2C%20Christopher">Stapleton, Christopher</a>; </li><li><a href="/search/?q=author%3ARabinov%2C%20James">Rabinov, James</a>; </li><li><a href="/search/?q=author%3AOta%2C%20Takahiro">Ota, Takahiro</a>; </li><li><a href="/search/?q=author%3ADofuku%2C%20Shogo">Dofuku, Shogo</a>; </li><li><a href="/search/?q=author%3AYeo%2C%20Leonard">Yeo, Leonard</a>; </li><li><a href="/search/?q=author%3ATan%2C%20Benjamin">Tan, Benjamin</a>; </li><li><a href="/search/?q=author%3AMartinez-Gutierrez%2C%20Juan">Martinez-Gutierrez, Juan</a>; </li><li><a href="/search/?q=author%3ASalazar-Marioni%2C%20Sergio">Salazar-Marioni, Sergio</a>; </li><li><a href="/search/?q=author%3ASheth%2C%20Sunil">Sheth, Sunil</a>; </li><li><a href="/search/?q=author%3ARenieri%2C%20Leonardo">Renieri, Leonardo</a>; </li><li><a href="/search/?q=author%3ACapirossi%2C%20Carolina">Capirossi, Carolina</a>; </li><li><a href="/search/?q=author%3AMowla%2C%20Ashkan">Mowla, Ashkan</a>; </li><li><a href="/search/?q=author%3ATjoumakaris%2C%20Stavropoula">Tjoumakaris, Stavropoula</a>; </li><li><a href="/search/?q=author%3AJabbour%2C%20Pascal">Jabbour, Pascal</a>; </li><li><a href="/search/?q=author%3AKhandelwal%2C%20Priyank">Khandelwal, Priyank</a>; </li><li><a href="/search/?q=author%3ABiswas%2C%20Arundhati">Biswas, Arundhati</a>; </li><li><a href="/search/?q=author%3AClaren%C3%A7on%2C%20Fr%C3%A9d%C3%A9ric">Clarençon, Frédéric</a>; </li><li><a href="/search/?q=author%3AElhorany%2C%20Mahmoud">Elhorany, Mahmoud</a>; </li><li><a href="/search/?q=author%3APremat%2C%20Kevin">Premat, Kevin</a>; </li><li><a href="/search/?q=author%3AValente%2C%20Iacopo">Valente, Iacopo</a>; </li><li><a href="/search/?q=author%3APedicelli%2C%20Alessandro">Pedicelli, Alessandro</a>; </li><li><a href="/search/?q=author%3APedro%20Filipe%2C%20Jo%C3%A3o">Pedro Filipe, João</a>; </li><li><a href="/search/?q=author%3AVarela%2C%20Ricardo">Varela, Ricardo</a>; </li><li><a href="/search/?q=author%3AQuintero-Consuegra%2C%20Miguel">Quintero-Consuegra, Miguel</a>; </li><li><a href="/search/?q=author%3AGonzalez%2C%20Nestor">Gonzalez, Nestor</a>; </li><li><a href="/search/?q=author%3AM%C3%B6hlenbruch%2C%20Markus">Möhlenbruch, Markus</a>; </li><li><a href="/search/?q=author%3AJesser%2C%20Jessica">Jesser, Jessica</a>; </li><li><a href="/search/?q=author%3ATancredi%2C%20Illario">Tancredi, Illario</a>; </li><li><a href="/search/?q=author%3ATer%20Schiphorst%2C%20Adrien">Ter Schiphorst, Adrien</a>; </li><li><a href="/search/?q=author%3AYedavalli%2C%20Vivek">Yedavalli, Vivek</a>; </li><li><a href="/search/?q=author%3AHarker%2C%20Pablo">Harker, Pablo</a>; </li><li><a href="/search/?q=author%3AChervak%2C%20Lina">Chervak, Lina</a>; </li><li><a href="/search/?q=author%3AAziz%2C%20Yasmin">Aziz, Yasmin</a>; </li><li><a href="/search/?q=author%3AGory%2C%20Benjamin">Gory, Benjamin</a>; </li><li><a href="/search/?q=author%3APaul%20Stracke%2C%20Christian">Paul Stracke, Christian</a>; </li><li><a href="/search/?q=author%3AHecker%2C%20Constantin">Hecker, Constantin</a>; </li><li><a href="/search/?q=author%3AKiller-Oberpfalzer%2C%20Monika">Killer-Oberpfalzer, Monika</a>; </li><li><a href="/search/?q=author%3AGriessenauer%2C%20Christoph">Griessenauer, Christoph</a>; </li><li><a href="/search/?q=author%3AThomas%2C%20Ajith">Thomas, Ajith</a>; </li><li><a href="/search/?q=author%3AHsieh%2C%20Cheng-Yang">Hsieh, Cheng-Yang</a>; </li><li><a href="/search/?q=author%3ALiebeskind%2C%20David">Liebeskind, David</a>; </li><li><a href="/search/?q=author%3AAlexandre%2C%20Andrea">Alexandre, Andrea</a>; </li><li><a href="/search/?q=author%3AFaizy%2C%20Tobias">Faizy, Tobias</a>; </li><li><a href="/search/?q=author%3AWeyland%2C%20Charlotte">Weyland, Charlotte</a>; </li><li><a href="/search/?q=author%3APatel%2C%20Aman">Patel, Aman</a>; </li><li><a href="/search/?q=author%3APereira%2C%20Vitor">Pereira, Vitor</a>; </li><li><a href="/search/?q=author%3ALubicz%2C%20Boris">Lubicz, Boris</a>; </li><li><a href="/search/?q=author%3ADmytriw%2C%20Adam">Dmytriw, Adam</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AGuenego%2C%20Adrien">Guenego, Adrien</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2024)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">INTRODUCTION: First pass effect (FPE), achievement of complete recanalization (mTICI 2c/3) with a single pass, is a significant predictor of favorable outcomes for endovascular treatment (EVT) in large vessel occlusion stroke (LVO). However, data concerning the impact on functional outcomes and predictors of FPE in medium vessel occlusions (MeVO) are scarce. PATIENTS AND METHODS: We conducted an international retrospective study on MeVO cases. Multivariable logistic modeling was used to establish independent predictors of FPE. Clinical and safety outcomes were compared between the two study groups (FPE vs non-FPE) using logistic regression models. Good outcome was defined as modified Rankin Scale 0-2 at 3 months. RESULTS: Eight hundred thirty-six patients with a final mTICI ⩾ 2b were included in this analysis. FPE was observed in 302 patients (36.1%). In multivariable analysis, hypertension (aOR 1.55, 95% CI 1.10-2.20) and lower baseline NIHSS score (aOR 0.95, 95% CI 0.93-0.97) were independently associated with an FPE. Good outcomes were more common in the FPE versus non-FPE group (72.8% vs 52.8%), and FPE was independently associated with favorable outcome (aOR 2.20, 95% CI 1.59-3.05). 90-day mortality and intracranial hemorrhage (ICH) were significantly lower in the FPE group, 0.43 (95% CI, 0.25-0.72) and 0.55 (95% CI, 0.39-0.77), respectively. CONCLUSION: Over 2/3 of patients with MeVOs and FPE in our cohort had a favorable outcome at 90 days. FPE is independently associated with favorable outcomes, it may reduce the risk of any intracranial hemorrhage, and 3-month mortality.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/6vj2189c"><img src="/cms-assets/96169ed661fced2551509d7800703597eb0a79adfb884f6386ac8915153158ea" alt="Cover page: First pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/9bb5z7h5"><div class="c-clientmarkup">Incidence and clinical outcomes of perforations during mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke: A retrospective, multicenter, and multinational study.</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ADmytriw%2C%20Adam">Dmytriw, Adam</a>; </li><li><a href="/search/?q=author%3AMusmar%2C%20Basel">Musmar, Basel</a>; </li><li><a href="/search/?q=author%3ASalim%2C%20Hamza">Salim, Hamza</a>; </li><li><a href="/search/?q=author%3AGhozy%2C%20Sherief">Ghozy, Sherief</a>; </li><li><a href="/search/?q=author%3ASiegler%2C%20James">Siegler, James</a>; </li><li><a href="/search/?q=author%3AKobeissi%2C%20Hassan">Kobeissi, Hassan</a>; </li><li><a href="/search/?q=author%3AShaikh%2C%20Hamza">Shaikh, Hamza</a>; </li><li><a href="/search/?q=author%3AKhalife%2C%20Jane">Khalife, Jane</a>; </li><li><a href="/search/?q=author%3AAbdalkader%2C%20Mohamad">Abdalkader, Mohamad</a>; </li><li><a href="/search/?q=author%3AKlein%2C%20Piers">Klein, Piers</a>; </li><li><a href="/search/?q=author%3ANguyen%2C%20Thanh">Nguyen, Thanh</a>; </li><li><a href="/search/?q=author%3AHeit%2C%20Jeremy">Heit, Jeremy</a>; </li><li><a href="/search/?q=author%3ARegenhardt%2C%20Robert">Regenhardt, Robert</a>; </li><li><a href="/search/?q=author%3ACancelliere%2C%20Nicole">Cancelliere, Nicole</a>; </li><li><a href="/search/?q=author%3ABernstock%2C%20Joshua">Bernstock, Joshua</a>; </li><li><a href="/search/?q=author%3ANaamani%2C%20Kareem">Naamani, Kareem</a>; </li><li><a href="/search/?q=author%3AAmllay%2C%20Abdelaziz">Amllay, Abdelaziz</a>; </li><li><a href="/search/?q=author%3AMeyer%2C%20Lukas">Meyer, Lukas</a>; </li><li><a href="/search/?q=author%3ADusart%2C%20Anne">Dusart, Anne</a>; </li><li><a href="/search/?q=author%3ABellante%2C%20Flavio">Bellante, Flavio</a>; </li><li><a href="/search/?q=author%3AForestier%2C%20G%C3%A9raud">Forestier, Géraud</a>; </li><li><a href="/search/?q=author%3ARouchaud%2C%20Aymeric">Rouchaud, Aymeric</a>; </li><li><a href="/search/?q=author%3ASaleme%2C%20Suzana">Saleme, Suzana</a>; </li><li><a href="/search/?q=author%3AMounayer%2C%20Charbel">Mounayer, Charbel</a>; </li><li><a href="/search/?q=author%3AFiehler%2C%20Jens">Fiehler, Jens</a>; </li><li><a href="/search/?q=author%3AK%C3%BChn%2C%20Anna">Kühn, Anna</a>; </li><li><a href="/search/?q=author%3APuri%2C%20Ajit">Puri, Ajit</a>; </li><li><a href="/search/?q=author%3ADyzmann%2C%20Christian">Dyzmann, Christian</a>; </li><li><a href="/search/?q=author%3AKan%2C%20Peter">Kan, Peter</a>; </li><li><a href="/search/?q=author%3AColasurdo%2C%20Marco">Colasurdo, Marco</a>; </li><li><a href="/search/?q=author%3AMarnat%2C%20Gaultier">Marnat, Gaultier</a>; </li><li><a href="/search/?q=author%3ABerge%2C%20J%C3%A9r%C3%B4me">Berge, Jérôme</a>; </li><li><a href="/search/?q=author%3ABarreau%2C%20Xavier">Barreau, Xavier</a>; </li><li><a href="/search/?q=author%3ASibon%2C%20Igor">Sibon, Igor</a>; </li><li><a href="/search/?q=author%3ANedelcu%2C%20Simona">Nedelcu, Simona</a>; </li><li><a href="/search/?q=author%3AHenninger%2C%20Nils">Henninger, Nils</a>; </li><li><a href="/search/?q=author%3AMarotta%2C%20Thomas">Marotta, Thomas</a>; </li><li><a href="/search/?q=author%3AStapleton%2C%20Christopher">Stapleton, Christopher</a>; </li><li><a href="/search/?q=author%3ARabinov%2C%20James">Rabinov, James</a>; </li><li><a href="/search/?q=author%3AOta%2C%20Takahiro">Ota, Takahiro</a>; </li><li><a href="/search/?q=author%3ADofuku%2C%20Shogo">Dofuku, Shogo</a>; </li><li><a href="/search/?q=author%3AYeo%2C%20Leonard">Yeo, Leonard</a>; </li><li><a href="/search/?q=author%3ATan%2C%20Benjamin">Tan, Benjamin</a>; </li><li><a href="/search/?q=author%3AGopinathan%2C%20Anil">Gopinathan, Anil</a>; </li><li><a href="/search/?q=author%3AMartinez-Gutierrez%2C%20Juan">Martinez-Gutierrez, Juan</a>; </li><li><a href="/search/?q=author%3ASalazar-Marioni%2C%20Sergio">Salazar-Marioni, Sergio</a>; </li><li><a href="/search/?q=author%3ASheth%2C%20Sunil">Sheth, Sunil</a>; </li><li><a href="/search/?q=author%3ARenieri%2C%20Leonardo">Renieri, Leonardo</a>; </li><li><a href="/search/?q=author%3ACapirossi%2C%20Carolina">Capirossi, Carolina</a>; </li><li><a href="/search/?q=author%3AMowla%2C%20Ashkan">Mowla, Ashkan</a>; </li><li><a href="/search/?q=author%3AChervak%2C%20Lina">Chervak, Lina</a>; </li><li><a href="/search/?q=author%3AVagal%2C%20Achala">Vagal, Achala</a>; </li><li><a href="/search/?q=author%3AAdeeb%2C%20Nimer">Adeeb, Nimer</a>; </li><li><a href="/search/?q=author%3ACuellar-Saenz%2C%20Hugo">Cuellar-Saenz, Hugo</a>; </li><li><a href="/search/?q=author%3ATjoumakaris%2C%20Stavropoula">Tjoumakaris, Stavropoula</a>; </li><li><a href="/search/?q=author%3AJabbour%2C%20Pascal">Jabbour, Pascal</a>; </li><li><a href="/search/?q=author%3AKhandelwal%2C%20Priyank">Khandelwal, Priyank</a>; </li><li><a href="/search/?q=author%3ABiswas%2C%20Arundhati">Biswas, Arundhati</a>; </li><li><a href="/search/?q=author%3AClaren%C3%A7on%2C%20Fr%C3%A9d%C3%A9ric">Clarençon, Frédéric</a>; </li><li><a href="/search/?q=author%3AElhorany%2C%20Mahmoud">Elhorany, Mahmoud</a>; </li><li><a href="/search/?q=author%3APremat%2C%20Kevin">Premat, Kevin</a>; </li><li><a href="/search/?q=author%3AValente%2C%20Iacopo">Valente, Iacopo</a>; </li><li><a href="/search/?q=author%3APedicelli%2C%20Alessandro">Pedicelli, Alessandro</a>; </li><li><a href="/search/?q=author%3AFilipe%2C%20Jo%C3%A3o">Filipe, João</a>; </li><li><a href="/search/?q=author%3AVarela%2C%20Ricardo">Varela, Ricardo</a>; </li><li><a href="/search/?q=author%3AQuintero-Consuegra%2C%20Miguel">Quintero-Consuegra, Miguel</a>; </li><li><a href="/search/?q=author%3AGonzalez%2C%20Nestor">Gonzalez, Nestor</a>; </li><li><a href="/search/?q=author%3AM%C3%B6hlenbruch%2C%20Markus">Möhlenbruch, Markus</a>; </li><li><a href="/search/?q=author%3AJesser%2C%20Jessica">Jesser, Jessica</a>; </li><li><a href="/search/?q=author%3ACostalat%2C%20Vincent">Costalat, Vincent</a>; </li><li><a href="/search/?q=author%3ATer%20Schiphorst%2C%20Adrien">Ter Schiphorst, Adrien</a>; </li><li><a href="/search/?q=author%3AYedavalli%2C%20Vivek">Yedavalli, Vivek</a>; </li><li><a href="/search/?q=author%3AHarker%2C%20Pablo">Harker, Pablo</a>; </li><li><a href="/search/?q=author%3AAziz%2C%20Yasmin">Aziz, Yasmin</a>; </li><li><a href="/search/?q=author%3AGory%2C%20Benjamin">Gory, Benjamin</a>; </li><li><a href="/search/?q=author%3AStracke%2C%20Christian">Stracke, Christian</a>; </li><li><a href="/search/?q=author%3AHecker%2C%20Constantin">Hecker, Constantin</a>; </li><li><a href="/search/?q=author%3AKadirvel%2C%20Ramanathan">Kadirvel, Ramanathan</a>; </li><li><a href="/search/?q=author%3AKiller-Oberpfalzer%2C%20Monika">Killer-Oberpfalzer, Monika</a>; </li><li><a href="/search/?q=author%3AGriessenauer%2C%20Christoph">Griessenauer, Christoph</a>; </li><li><a href="/search/?q=author%3AThomas%2C%20Ajith">Thomas, Ajith</a>; </li><li><a href="/search/?q=author%3AHsieh%2C%20Cheng-Yang">Hsieh, Cheng-Yang</a>; </li><li><a href="/search/?q=author%3ALiebeskind%2C%20David">Liebeskind, David</a>; </li><li><a href="/search/?q=author%3AAlexandru%20Radu%2C%20R%C4%83zvan">Alexandru Radu, Răzvan</a>; </li><li><a href="/search/?q=author%3AAlexandre%2C%20Andrea">Alexandre, Andrea</a>; </li><li><a href="/search/?q=author%3ATancredi%2C%20Illario">Tancredi, Illario</a>; </li><li><a href="/search/?q=author%3AFaizy%2C%20Tobias">Faizy, Tobias</a>; </li><li><a href="/search/?q=author%3AFahed%2C%20Robert">Fahed, Robert</a>; </li><li><a href="/search/?q=author%3AWeyland%2C%20Charlotte">Weyland, Charlotte</a>; </li><li><a href="/search/?q=author%3ALubicz%2C%20Boris">Lubicz, Boris</a>; </li><li><a href="/search/?q=author%3APatel%2C%20Aman">Patel, Aman</a>; </li><li><a href="/search/?q=author%3APereira%2C%20Vitor">Pereira, Vitor</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3AGuenego%2C%20Adrien">Guenego, Adrien</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucla_postprints">UCLA Previously Published Works</a> (2024)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup">BACKGROUND: Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium vessel occlusion (MeVO) remain less explored. This multicenter, retrospective study aims to investigate the incidence and clinical outcomes of vessel perforations (confirmed by extravasation during an angiographic series) during MT for AIS caused by MeVO. METHODS: Data were collected from 37 academic centers across North America, Asia, and Europe between September 2017 and July 2021. A total of 1373 AIS patients with MeVO underwent MT. Baseline characteristics, procedural details, and clinical outcomes were analyzed. RESULTS: The incidence of vessel perforation was 4.8% (66/1373). Notably, our analysis indicates variations in perforation rates across different arterial segments: 8.9% in M3 segments, 4.3% in M2 segments, and 8.3% in A2 segments (p = 0.612). Patients with perforation had significantly worse outcomes, with lower rates of favorable angiographic outcomes (TICI 2c-3: 23% vs 58.9%, p < 0.001; TICI 2b-3: 56.5% vs 88.3%, p < 0.001). Functional outcomes were also worse in the perforation group (mRS 0-1 at 3 months: 22.7% vs 36.6%, p = 0.031; mRS 0-2 at 3 months: 28.8% vs 53.9%, p < 0.001). Mortality was higher in the perforation group (30.3% vs 16.8%, p = 0.008). CONCLUSION: This study reveals that while the occurrence of vessel perforation in MT for AIS due to MeVO is relatively rare, it is associated with poor functional outcomes and higher mortality. The findings highlight the need for increased caution and specialized training in performing MT for MeVO. Further prospective research is required for risk mitigation strategies.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/9bb5z7h5"><img src="/cms-assets/b233670e982dd89b855240266b93ffc12801dabb6b6e0047c91a661f6eaad081" alt="Cover page: Incidence and clinical outcomes of perforations during mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke: A retrospective, multicenter, and multinational study."/></a></div></section><section class="c-scholworks"><div class="c-scholworks__main-column"><ul class="c-scholworks__tag-list"><li class="c-scholworks__tag-article">Article</li><li class="c-scholworks__tag-peer">Peer Reviewed</li></ul><div><h3 class="c-scholworks__heading"><a href="/uc/item/77h924cw"><div class="c-clientmarkup">Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID-19 pandemic</div></a></h3></div><div class="c-authorlist"><ul class="c-authorlist__list"><li class="c-authorlist__begin"><a href="/search/?q=author%3ANguyen%2C%20Thanh%20N">Nguyen, Thanh N</a>; </li><li><a href="/search/?q=author%3AHaussen%2C%20Diogo%20C">Haussen, Diogo C</a>; </li><li><a href="/search/?q=author%3AQureshi%2C%20Muhammad%20M">Qureshi, Muhammad M</a>; </li><li><a href="/search/?q=author%3AYamagami%2C%20Hiroshi">Yamagami, Hiroshi</a>; </li><li><a href="/search/?q=author%3AFujinaka%2C%20Toshiyuki">Fujinaka, Toshiyuki</a>; </li><li><a href="/search/?q=author%3AMansour%2C%20Ossama%20Y">Mansour, Ossama Y</a>; </li><li><a href="/search/?q=author%3AAbdalkader%2C%20Mohamad">Abdalkader, Mohamad</a>; </li><li><a href="/search/?q=author%3AFrankel%2C%20Michael">Frankel, Michael</a>; </li><li><a href="/search/?q=author%3AQiu%2C%20Zhongming">Qiu, Zhongming</a>; </li><li><a href="/search/?q=author%3ATaylor%2C%20Allan">Taylor, Allan</a>; </li><li><a href="/search/?q=author%3ALylyk%2C%20Pedro">Lylyk, Pedro</a>; </li><li><a href="/search/?q=author%3AEker%2C%20Omer%20F">Eker, Omer F</a>; </li><li><a href="/search/?q=author%3AMechtouff%2C%20Laura">Mechtouff, Laura</a>; </li><li><a href="/search/?q=author%3APiotin%2C%20Michel">Piotin, Michel</a>; </li><li><a href="/search/?q=author%3ALima%2C%20Fabricio%20Oliveira">Lima, Fabricio Oliveira</a>; </li><li><a href="/search/?q=author%3AMont'Alverne%2C%20Francisco">Mont'Alverne, Francisco</a>; </li><li><a href="/search/?q=author%3AIzzath%2C%20Wazim">Izzath, Wazim</a>; </li><li><a href="/search/?q=author%3ASakai%2C%20Nobuyuki">Sakai, Nobuyuki</a>; </li><li><a href="/search/?q=author%3AMohammaden%2C%20Mahmoud">Mohammaden, Mahmoud</a>; </li><li><a href="/search/?q=author%3AAl-Bayati%2C%20Alhamza%20R">Al-Bayati, Alhamza R</a>; </li><li><a href="/search/?q=author%3ARenieri%2C%20Leonardo">Renieri, Leonardo</a>; </li><li><a href="/search/?q=author%3AMangiafico%2C%20Salvatore">Mangiafico, Salvatore</a>; </li><li><a href="/search/?q=author%3AOzretic%2C%20David">Ozretic, David</a>; </li><li><a href="/search/?q=author%3AChalumeau%2C%20Vanessa">Chalumeau, Vanessa</a>; </li><li><a href="/search/?q=author%3AAhmad%2C%20Saima">Ahmad, Saima</a>; </li><li><a href="/search/?q=author%3ARashid%2C%20Umair">Rashid, Umair</a>; </li><li><a href="/search/?q=author%3AHussain%2C%20Syed%20Irteza">Hussain, Syed Irteza</a>; </li><li><a href="/search/?q=author%3AJohn%2C%20Seby">John, Seby</a>; </li><li><a href="/search/?q=author%3AGriffin%2C%20Emma">Griffin, Emma</a>; </li><li><a href="/search/?q=author%3AThornton%2C%20John">Thornton, John</a>; </li><li><a href="/search/?q=author%3AFiorot%2C%20Jose%20Antonio">Fiorot, Jose Antonio</a>; </li><li><a href="/search/?q=author%3ARivera%2C%20Rodrigo">Rivera, Rodrigo</a>; </li><li><a href="/search/?q=author%3AHammami%2C%20Nadia">Hammami, Nadia</a>; </li><li><a href="/search/?q=author%3ACervantes-Arslanian%2C%20Anna%20M">Cervantes-Arslanian, Anna M</a>; </li><li><a href="/search/?q=author%3ADasenbrock%2C%20Hormuzdiyar%20H">Dasenbrock, Hormuzdiyar H</a>; </li><li><a href="/search/?q=author%3AVu%2C%20Huynh%20Le">Vu, Huynh Le</a>; </li><li><a href="/search/?q=author%3ANguyen%2C%20Viet%20Quy">Nguyen, Viet Quy</a>; </li><li><a href="/search/?q=author%3AHetts%2C%20Steven">Hetts, Steven</a>; </li><li><a href="/search/?q=author%3ABourcier%2C%20Romain">Bourcier, Romain</a>; </li><li><a href="/search/?q=author%3AGuile%2C%20Romain">Guile, Romain</a>; </li><li><a href="/search/?q=author%3AWalker%2C%20Melanie">Walker, Melanie</a>; </li><li><a href="/search/?q=author%3ASharma%2C%20Malveeka">Sharma, Malveeka</a>; </li><li><a href="/search/?q=author%3AFrei%2C%20Don">Frei, Don</a>; </li><li><a href="/search/?q=author%3AJabbour%2C%20Pascal">Jabbour, Pascal</a>; </li><li><a href="/search/?q=author%3AHerial%2C%20Nabeel">Herial, Nabeel</a>; </li><li><a href="/search/?q=author%3AAl-Mufti%2C%20Fawaz">Al-Mufti, Fawaz</a>; </li><li><a href="/search/?q=author%3AOzdemir%2C%20Atilla%20Ozcan">Ozdemir, Atilla Ozcan</a>; </li><li><a href="/search/?q=author%3AAykac%2C%20Ozlem">Aykac, Ozlem</a>; </li><li><a href="/search/?q=author%3AGandhi%2C%20Dheeraj">Gandhi, Dheeraj</a>; </li><li><a href="/search/?q=author%3AChugh%2C%20Chandril">Chugh, Chandril</a>; </li><li><a href="/search/?q=author%3AMatouk%2C%20Charles">Matouk, Charles</a>; </li><li><a href="/search/?q=author%3ALavoie%2C%20Pascale">Lavoie, Pascale</a>; </li><li><a href="/search/?q=author%3AEdgell%2C%20Randall">Edgell, Randall</a>; </li><li><a href="/search/?q=author%3ABeer-Furlan%2C%20Andre">Beer-Furlan, Andre</a>; </li><li><a href="/search/?q=author%3AChen%2C%20Michael">Chen, Michael</a>; </li><li><a href="/search/?q=author%3AKiller-Oberpfalzer%2C%20Monika">Killer-Oberpfalzer, Monika</a>; </li><li><a href="/search/?q=author%3APereira%2C%20Vitor%20Mendes">Pereira, Vitor Mendes</a>; </li><li><a href="/search/?q=author%3ANicholson%2C%20Patrick">Nicholson, Patrick</a>; </li><li><a href="/search/?q=author%3AHuded%2C%20Vikram">Huded, Vikram</a>; </li><li><a href="/search/?q=author%3AOhara%2C%20Nobuyuki">Ohara, Nobuyuki</a>; </li><li><a href="/search/?q=author%3AWatanabe%2C%20Daisuke">Watanabe, Daisuke</a>; </li><li><a href="/search/?q=author%3AShin%2C%20Dong%20Hun">Shin, Dong Hun</a>; </li><li><a href="/search/?q=author%3AMagalhaes%2C%20Pedro%20SC">Magalhaes, Pedro SC</a>; </li><li><a href="/search/?q=author%3AKikano%2C%20Raghid">Kikano, Raghid</a>; </li><li><a href="/search/?q=author%3AOrtega-Gutierrez%2C%20Santiago">Ortega-Gutierrez, Santiago</a>; </li><li><a href="/search/?q=author%3AFarooqui%2C%20Mudassir">Farooqui, Mudassir</a>; </li><li><a href="/search/?q=author%3AAbou-Hamden%2C%20Amal">Abou-Hamden, Amal</a>; </li><li><a href="/search/?q=author%3AAmano%2C%20Tatsuo">Amano, Tatsuo</a>; </li><li><a href="/search/?q=author%3AYamamoto%2C%20Ryoo">Yamamoto, Ryoo</a>; </li><li><a href="/search/?q=author%3AWeeks%2C%20Adrienne">Weeks, Adrienne</a>; </li><li><a href="/search/?q=author%3ACora%2C%20Elena%20A">Cora, Elena A</a>; </li><li><a href="/search/?q=author%3ASivan-Hoffmann%2C%20Rotem">Sivan-Hoffmann, Rotem</a>; </li><li><a href="/search/?q=author%3ACrosa%2C%20Roberto">Crosa, Roberto</a>; </li><li><a href="/search/?q=author%3AM%C3%B6hlenbruch%2C%20Markus">Möhlenbruch, Markus</a>; </li><li><a href="/search/?q=author%3ANagel%2C%20Simon">Nagel, Simon</a>; </li><li><a href="/search/?q=author%3AAl-Jehani%2C%20Hosam">Al-Jehani, Hosam</a>; </li><li><a href="/search/?q=author%3ASheth%2C%20Sunil%20A">Sheth, Sunil A</a>; </li><li><a href="/search/?q=author%3ALopez%20Rivera%2C%20Victor%20S">Lopez Rivera, Victor S</a>; </li><li><a href="/search/?q=author%3ASiegler%2C%20James%20E">Siegler, James E</a>; </li><li><a href="/search/?q=author%3ASani%2C%20Achmad%20Fidaus">Sani, Achmad Fidaus</a>; </li><li><a href="/search/?q=author%3APuri%2C%20Ajit%20S">Puri, Ajit S</a>; </li><li><a href="/search/?q=author%3AKuhn%2C%20Anna%20Luisa">Kuhn, Anna Luisa</a>; </li><li><a href="/search/?q=author%3ABernava%2C%20Gianmarco">Bernava, Gianmarco</a>; </li><li><a href="/search/?q=author%3AMachi%2C%20Paolo">Machi, Paolo</a>; </li><li><a href="/search/?q=author%3AAbud%2C%20Daniel%20G">Abud, Daniel G</a>; </li><li><a href="/search/?q=author%3APontes-Neto%2C%20Octavio%20M">Pontes-Neto, Octavio M</a>; </li><li><a href="/search/?q=author%3AWakhloo%2C%20Ajay%20K">Wakhloo, Ajay K</a>; </li><li><a href="/search/?q=author%3AVoetsch%2C%20Barbara">Voetsch, Barbara</a>; </li><li><a href="/search/?q=author%3ARaz%2C%20Eytan">Raz, Eytan</a>; </li><li><a href="/search/?q=author%3AYaghi%2C%20Shadi">Yaghi, Shadi</a>; </li><li><a href="/search/?q=author%3AMehta%2C%20Brijesh%20P">Mehta, Brijesh P</a>; </li><li><a href="/search/?q=author%3AKimura%2C%20Naoto">Kimura, Naoto</a>; </li><li><a href="/search/?q=author%3AMurakami%2C%20Mamoru">Murakami, Mamoru</a>; </li><li><a href="/search/?q=author%3ALee%2C%20Jin%20Soo">Lee, Jin Soo</a>; </li><li><a href="/search/?q=author%3AHong%2C%20Ji%20Man">Hong, Ji Man</a>; </li><li><a href="/search/?q=author%3AFahed%2C%20Robert">Fahed, Robert</a>; </li><li><a href="/search/?q=author%3AWalker%2C%20Gregory">Walker, Gregory</a>; </li><li><a href="/search/?q=author%3AHagashi%2C%20Eiji">Hagashi, Eiji</a>; </li><li><a href="/search/?q=author%3ACordina%2C%20Steve%20M">Cordina, Steve M</a>; </li><li><a href="/search/?q=author%3ARoh%2C%20Hong%20Gee">Roh, Hong Gee</a>; </li><li><a href="/search/?q=author%3AWong%2C%20Ken">Wong, Ken</a>; </li><li><a href="/search/?q=author%3AArenillas%2C%20Juan%20F">Arenillas, Juan F</a>; </li><li><a href="/search/?q=author%3AMartinez-Galdamez%2C%20Mario">Martinez-Galdamez, Mario</a>; </li><li><a href="/search/?q=author%3ABlasco%2C%20Jordi">Blasco, Jordi</a>; </li><li><a href="/search/?q=author%3ARodriguez%20Vasquez%2C%20Alejandro">Rodriguez Vasquez, Alejandro</a>; </li><li><a href="/search/?q=author%3AFonseca%2C%20Luisa">Fonseca, Luisa</a>; </li><li><a href="/search/?q=author%3ASilva%2C%20M%20Luis">Silva, M Luis</a>; </li><li><a href="/search/?q=author%3AWu%2C%20Teddy%20Y">Wu, Teddy Y</a>; </li><li><a href="/search/?q=author%3AJohn%2C%20Simon">John, Simon</a>; </li><li><a href="/search/?q=author%3ABrehm%2C%20Alex">Brehm, Alex</a>; </li><li><a href="/search/?q=author%3APsychogios%2C%20Marios">Psychogios, Marios</a>; </li><li><a href="/search/?q=author%3AMack%2C%20William%20J">Mack, William J</a>; </li><li><a href="/search/?q=author%3ATenser%2C%20Matthew">Tenser, Matthew</a>; </li><li><a href="/search/?q=author%3ATodaka%2C%20Tatemi">Todaka, Tatemi</a>; </li><li><a href="/search/?q=author%3AFujimura%2C%20Miki">Fujimura, Miki</a>; </li><li><a href="/search/?q=author%3ANovakovic%2C%20Roberta">Novakovic, Roberta</a>; </li><li><a href="/search/?q=author%3ADeguchi%2C%20Jun">Deguchi, Jun</a>; </li><li><a href="/search/?q=author%3ASugiura%2C%20Yuri">Sugiura, Yuri</a>; </li><li><a href="/search/?q=author%3ATokimura%2C%20Hiroshi">Tokimura, Hiroshi</a>; </li><li><a href="/search/?q=author%3AKhatri%2C%20Rakesh">Khatri, Rakesh</a>; </li><li><a href="/search/?q=author%3AKelly%2C%20Michael">Kelly, Michael</a>; </li><li><a href="/search/?q=author%3APeeling%2C%20Lissa">Peeling, Lissa</a>; </li><li><a href="/search/?q=author%3AMurayama%2C%20Yuichi">Murayama, Yuichi</a>; </li><li><a href="/search/?q=author%3AWinters%2C%20Hugh%20Stephen">Winters, Hugh Stephen</a>; </li><li><a href="/search/?q=author%3AWong%2C%20Johnny">Wong, Johnny</a>; </li><li><a href="/search/?q=author%3ATeleb%2C%20Mohamed">Teleb, Mohamed</a>; </li><li><a href="/search/?q=author%3APayne%2C%20Jeremy">Payne, Jeremy</a>; </li><li><a href="/search/?q=author%3AFukuda%2C%20Hiroki">Fukuda, Hiroki</a>; </li><li><a href="/search/?q=author%3AMiyake%2C%20Kosuke">Miyake, Kosuke</a>; </li><li><a href="/search/?q=author%3AShimbo%2C%20Junsuke">Shimbo, Junsuke</a>; </li><li><a href="/search/?q=author%3ASugimura%2C%20Yusuke">Sugimura, Yusuke</a>; </li><li><a href="/search/?q=author%3AUno%2C%20Masaaki">Uno, Masaaki</a>; </li><li><a href="/search/?q=author%3ATakenobu%2C%20Yohei">Takenobu, Yohei</a>; </li><li><a href="/search/?q=author%3AMatsumaru%2C%20Yuji">Matsumaru, Yuji</a>; </li><li><a href="/search/?q=author%3AYamada%2C%20Satoshi">Yamada, Satoshi</a>; </li><li><a href="/search/?q=author%3AKono%2C%20Ryuhei">Kono, Ryuhei</a>; </li><li><a href="/search/?q=author%3AKanamaru%2C%20Takuya">Kanamaru, Takuya</a>; </li><li><a href="/search/?q=author%3AMorimoto%2C%20Masafumi">Morimoto, Masafumi</a>; </li><li><a href="/search/?q=author%3AIida%2C%20Junichi">Iida, Junichi</a>; </li><li><a href="/search/?q=author%3ASaini%2C%20Vasu">Saini, Vasu</a>; </li><li><a href="/search/?q=author%3AYavagal%2C%20Dileep">Yavagal, Dileep</a>; </li><li><a href="/search/?q=author%3ABushnaq%2C%20Saif">Bushnaq, Saif</a>; </li><li><a href="/search/?q=author%3AHuang%2C%20Wenguo">Huang, Wenguo</a>; </li><li><a href="/search/?q=author%3ALinfante%2C%20Italo">Linfante, Italo</a>; </li><li><a href="/search/?q=author%3AKirmani%2C%20Jawad">Kirmani, Jawad</a>; </li><li><a href="/search/?q=author%3ALiebeskind%2C%20David%20S">Liebeskind, David S</a>; </li><li><a href="/search/?q=author%3ASzeder%2C%20Viktor">Szeder, Viktor</a>; </li><li><a href="/search/?q=author%3AShah%2C%20Ruchir">Shah, Ruchir</a>; </li><li><a href="/search/?q=author%3ADevlin%2C%20Thomas%20G">Devlin, Thomas G</a>; </li><li><a href="/search/?q=author%3ABirnbaum%2C%20Lee">Birnbaum, Lee</a>; </li><li><a href="/search/?q=author%3ALuo%2C%20Jun">Luo, Jun</a>; </li><li><a href="/search/?q=author%3AChurojana%2C%20Anchalee">Churojana, Anchalee</a>; </li><li><a href="/search/?q=author%3AMasoud%2C%20Hesham%20E">Masoud, Hesham E</a>; </li><li><a href="/search/?q=author%3ALopez%2C%20Carlos%20Ynigo">Lopez, Carlos Ynigo</a>; </li><li><a href="/search/?q=author%3ASteinfort%2C%20Brendan">Steinfort, Brendan</a>; </li><li><a href="/search/?q=author%3AMa%2C%20Alice">Ma, Alice</a>; </li><li><a href="/search/?q=author%3AHassan%2C%20Ameer%20E">Hassan, Ameer E</a>; </li><li><a href="/search/?q=author%3AAl%20Hashmi%2C%20Amal">Al Hashmi, Amal</a>; </li><li><a href="/search/?q=author%3AMcDermott%2C%20Mollie">McDermott, Mollie</a>; </li><li><a href="/search/?q=author%3AMokin%2C%20Maxim">Mokin, Maxim</a>; </li><li><a href="/search/?q=author%3AChebl%2C%20Alex">Chebl, Alex</a>; </li><li><a href="/search/?q=author%3AKargiotis%2C%20Odysseas">Kargiotis, Odysseas</a>; </li><li><a href="/search/?q=author%3ATsivgoulis%2C%20Georgios">Tsivgoulis, Georgios</a>; </li><li><a href="/search/?q=author%3AMorris%2C%20Jane%20G">Morris, Jane G</a>; </li><li><a href="/search/?q=author%3AEskey%2C%20Clifford%20J">Eskey, Clifford J</a>; </li><li><a href="/search/?q=author%3AThon%2C%20Jesse">Thon, Jesse</a>; </li><li><a href="/search/?q=author%3ARebello%2C%20Leticia">Rebello, Leticia</a>; </li><li><a href="/search/?q=author%3AAltschul%2C%20Dorothea">Altschul, Dorothea</a>; </li><li><a href="/search/?q=author%3ACornett%2C%20Oriana">Cornett, Oriana</a>; </li><li><a href="/search/?q=author%3ASingh%2C%20Varsha">Singh, Varsha</a>; </li><li><a href="/search/?q=author%3APandian%2C%20Jeyaraj">Pandian, Jeyaraj</a>; </li><li><a href="/search/?q=author%3AKulkarni%2C%20Anirudh">Kulkarni, Anirudh</a>; </li><li><a href="/search/?q=author%3ALavados%2C%20Pablo%20M">Lavados, Pablo M</a>; </li><li><a href="/search/?q=author%3AOlavarria%2C%20Veronica%20V">Olavarria, Veronica V</a>; </li><li><a href="/search/?q=author%3ATodo%2C%20Kenichi">Todo, Kenichi</a>; </li><li><a href="/search/?q=author%3AYamamoto%2C%20Yuki">Yamamoto, Yuki</a>; </li><li><a href="/search/?q=author%3ASilva%2C%20Gisele%20Sampaio">Silva, Gisele Sampaio</a>; </li><li><a href="/search/?q=author%3AGeyik%2C%20Serdar">Geyik, Serdar</a>; </li><li><a href="/search/?q=author%3AJohann%2C%20Jasmine">Johann, Jasmine</a>; </li><li><a href="/search/?q=author%3AMultani%2C%20Sumeet">Multani, Sumeet</a>; </li><li><a href="/search/?q=author%3AKaliaev%2C%20Artem">Kaliaev, Artem</a>; </li><li><a href="/search/?q=author%3ASonoda%2C%20Kazutaka">Sonoda, Kazutaka</a>; </li><li><a href="/search/?q=author%3AHashimoto%2C%20Hiroyuki">Hashimoto, Hiroyuki</a>; </li><li><a href="/search/?q=author%3AAlhazzani%2C%20Adel">Alhazzani, Adel</a>; </li><li><a href="/search/?q=author%3AChung%2C%20David%20Y">Chung, David Y</a>; </li><li><a href="/search/?q=author%3AMayer%2C%20Stephan%20A">Mayer, Stephan A</a>; </li><li><a href="/search/?q=author%3AFifi%2C%20Johanna%20T">Fifi, Johanna T</a>; </li><li><a href="/search/?q=author%3AHill%2C%20Michael%20D">Hill, Michael D</a>; </li><li><a href="/search/?q=author%3AZhang%2C%20Hao">Zhang, Hao</a>; </li><li><a href="/search/?q=author%3AYuan%2C%20Zhengzhou">Yuan, Zhengzhou</a>; </li><li><a href="/search/?q=author%3AShang%2C%20Xianjin">Shang, Xianjin</a>; </li><li><a href="/search/?q=author%3ACastonguay%2C%20Alicia%20C">Castonguay, Alicia C</a>; </li><li><a href="/search/?q=author%3AGupta%2C%20Rishi">Gupta, Rishi</a>; </li><li><a href="/search/?q=author%3AJovin%2C%20Tudor%20G">Jovin, Tudor G</a>; </li><li><a href="/search/?q=author%3ARaymond%2C%20Jean">Raymond, Jean</a>; </li><li><a href="/search/?q=author%3AZaidat%2C%20Osama%20O">Zaidat, Osama O</a>; </li><li class="c-authorlist__end"><a href="/search/?q=author%3ANogueira%2C%20Raul%20G">Nogueira, Raul G</a> </li></ul></div><div class="c-scholworks__publication"><a href="/uc/ucsf_postprints">UC San Francisco Previously Published Works</a> (2021)</div><div class="c-scholworks__abstract"><div class="c-clientmarkup"><h3>Background</h3>During the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study's objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.<h3>Methods</h3>We conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries and 140 comprehensive stroke centres. Patients with the diagnosis of SAH, aneurysmal SAH, ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases, 10th Revision, codes. The 3-month cumulative volume, monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before (1 year and immediately before) and during the pandemic, defined as 1 March-31 May 2020. The prior 1-year control period (1 March-31 May 2019) was obtained to account for seasonal variation.<h3>Findings</h3>There was a significant decline in SAH hospitalisations, with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic, representing a relative decline of 22.5% (95% CI -24.3% to -20.7%, p<0.0001). Embolisation of ruptured aneurysms declined with 1170-1035 procedures, respectively, representing an 11.5% (95%CI -13.5% to -9.8%, p=0.002) relative drop. Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations, a 24.9% relative decline (95% CI -28.0% to -22.1%, p<0.0001). A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1% (95% CI 32.3% to 50.6%, p=0.008) despite a decrease in SAH admissions in this tertile.<h3>Interpretation</h3>There was a relative decrease in the volume of SAH hospitalisations, aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic. These findings in SAH are consistent with a decrease in other emergencies, such as stroke and myocardial infarction.</div></div><div class="c-scholworks__media"><ul class="c-medialist"></ul></div></div><div class="c-scholworks__ancillary"><a class="c-scholworks__thumbnail" href="/uc/item/77h924cw"><img src="/cms-assets/ad37f7363d2ba2105ef90cc1279390b3cd2fe3df8343a679be125fb6ce2785ab" alt="Cover page: Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID-19 pandemic"/></a><a href="https://creativecommons.org/licenses/by-nc/4.0/" class="c-scholworks__license"><img class="c-lazyimage" data-src="/images/cc-by-nc-small.svg" alt="Creative Commons 'BY-NC' version 4.0 license"/></a></div></section></section></main></form></div><div><div class="c-toplink"><a href="javascript:window.scrollTo(0, 0)">Top</a></div><footer class="c-footer"><nav class="c-footer__nav"><ul><li><a href="/">Home</a></li><li><a href="/aboutEschol">About eScholarship</a></li><li><a href="/campuses">Campus Sites</a></li><li><a href="/ucoapolicies">UC Open Access Policy</a></li><li><a href="/publishing">eScholarship Publishing</a></li><li><a href="https://www.cdlib.org/about/accessibility.html">Accessibility</a></li><li><a href="/privacypolicy">Privacy Statement</a></li><li><a href="/policies">Site Policies</a></li><li><a href="/terms">Terms of Use</a></li><li><a href="/login"><strong>Admin Login</strong></a></li><li><a href="https://help.escholarship.org"><strong>Help</strong></a></li></ul></nav><div class="c-footer__logo"><a href="/"><img class="c-lazyimage" data-src="/images/logo_footer-eschol.svg" alt="eScholarship, University of California"/></a></div><div class="c-footer__copyright">Powered by the<br/><a href="http://www.cdlib.org">California Digital Library</a><br/>Copyright © 2017<br/>The Regents of the University of California</div></footer></div></div></div></div> <script src="/js/vendors~app-bundle-2aefc956e545366a5d4e.js"></script> <script src="/js/app-bundle-3c8ebc2ec05dcc3202fd.js"></script> </body> </html>