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<style> body {background-color:#ffffff; } h1, h3, h5, caption, aside h2, .maincolortxt, .posttitle, #intro { color:#31708e; } h2 { color:#f18a01; } .maincolor, #intro .button { background-color:#31708e; } .seccolor { background-color:#f18a01; } .maincolortxt { color:#31708e; } .seccolortxt { color:#f18a01; } .acc_color1 {background-color:#56a027; } .acc_color1txt {color:#56a027; } .acc_color2 {background-color:#303030; } .acc_color2txt {color:#303030; } .ftcolor {background-color:#5085a5;} .bgcolor2 {background-color:#efefef; } hr {color:#efefef; } ul {list-style-color: #f18a01; } .bordertopcolor {border-top: 16px solid #ffffff; } .wideimage img {border-bottom: 10px solid #efefef;} </style> <link rel="stylesheet" type="text/css" href="https://adrenoleukodystrophy.info/wp-content/themes/quest-for-helmsdeep/customizer-values-css.php" /> </head> <body class="front"> <header role="banner"> <a href="https://adrenoleukodystrophy.info"> <img src="https://adrenoleukodystrophy.info/wp-content/uploads/2018/05/ALDinfo_logo.png" alt="" class="logo"></a> </header> <section class="wideimage" role="img"> <img src="https://adrenoleukodystrophy.info/wp-content/uploads/2017/09/ThinkstockPhotos-451076571-5x1.jpg" alt="" /> <p> The information platform to all aspects of adrenoleukodystrophy and the worldwide registry for ABCD1 variants</p> </section> <main role="main"> <section id="intro" class="row"> <h1>Adrenoleukodystrophy</h1> <div class="seccolumn2"><p>X-linked adrenoleukodystrophy (ALD) is an inherited metabolic disorder that affects the brain, spinal cord, and adrenal glands.<br /> ALD.info provides information on all aspects of ALD written and maintained by ALD researchers and physicians.<br /> Translations are available in Español, Deutch, Français or Nederlands (see the <a href="https://adrenoleukodystrophy.info/about/sitemap">sitemap</a>). For a comprehensive summary and video, please visit the <a href="http://adrenoleukodystrophy.info/clinical-diagnosis/facts-on-ald">“Facts about ALD”</a> page.</p> <p>Adrenoleukodystrophy is caused by pathogenic variants in the <em>ABCD1</em> gene. The <a href="http://adrenoleukodystrophy.info/mutations-and-variants-in-abcd1"><em>ABCD1</em> Variant Registry</a>, available since 1999, is a publicly accessible registry that currently catalogs &gt;1230 unique <em>ABCD1</em> variants.<br /> To learn more about the utility of the database as a scientific, clinical, and ALD community-wide resource, please read our Open Access <a href="https://www.mdpi.com/2073-4409/11/2/283">publication</a>.</p> </div> </section> <section class="row"> <article class="threeblock tbone"> <img src="https://adrenoleukodystrophy.info/wp-content/uploads/2017/09/biochemistry.jpg" class="blockimg" alt=""> <h2 class="bluetext">Clinical &#038; Diagnosis</h2> <p class="fpheight">This section includes pages on the facts about adrenoleukodystrophy, newborn screening, clinical presentations, and educational videos and webinars.</p><a class="button seccolor" rel="bookmark" href="https://adrenoleukodystrophy.info/clinical-diagnosis/clinical-diagnosis">Read more</a> </article> <article class="threeblock tbtwo"> <img src="https://adrenoleukodystrophy.info/wp-content/uploads/2017/09/treatment1.jpg" class="blockimg" alt=""> <h2 class="bluetext">Treatment options</h2> <p class="fpheight">This section includes pages about treatment options for adrenoleukodystrophy, adrenal insufficiency, hematopoietic stem cell transplantation, gene therapy, etc.</p><a class="button seccolor" rel="bookmark" href="https://adrenoleukodystrophy.info/treatment-options/treatment-options">Read more</a> </article> <article class="threeblock tbthree"> <img src="https://adrenoleukodystrophy.info/wp-content/uploads/2017/09/dna_400x240.jpg" class="blockimg" alt=""> <h2 class="bluetext">Variants &#038; Biochemistry</h2> <p class="fpheight">This section contains the ABCD1 Variant Database, info on the underlying genetics and biochemistry, etc.</p><a class="button seccolor" rel="bookmark" href="https://adrenoleukodystrophy.info/mutations-biochemistry/mutations-biochemistry">Read more</a> </article> </section> <div class="bgcolor2 bordertopcolor"> <section class="row nobmargin"> <article class="twoblock tbfirst white"> <h2 class="acc_color1txt">Variants of Uncertain Significance</h2> <p class="fpheight">Babies with adrenoleukodystrophy (ALD) are neurologically normal at birth. Boys with ALD are at risk of developing adrenal insufficiency and/or inflammatory demyelinating brain lesions (cerebral ALD). Newborn screening has revolutionized...</p><a class="button acc_color1" rel="bookmark" href="https://adrenoleukodystrophy.info/variants-of-uncertain-significance">Read More</a><!-- <p> <a href="#" class="">' . __('Read more', 'quest-for-helmsdeep' ) . '</a> </p>--> </article> <article class="twoblock tbsecond white"> <h2 class="maincolortxt">Hugo Moser</h2> <p class="fpheight">Baltimore, MD – Hugo W. Moser, recognized throughout the world for his research on genetic disorders that affect nervous system function in children, passed away on Saturday, January 20th 2007...</p><a class="button maincolor" rel="bookmark" href="https://adrenoleukodystrophy.info/hugo-moser">Read More</a><!-- <p> <a href="#" class="">' . __('Read more', 'quest-for-helmsdeep' ) . 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