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<span class="vector-toc-numb">2</span> <span>Structure</span> </div> </a> <button aria-controls="toc-Structure-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Structure subsection</span> </button> <ul id="toc-Structure-sublist" class="vector-toc-list"> <li id="toc-Phosphorylation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Phosphorylation"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Phosphorylation</span> </div> </a> <ul id="toc-Phosphorylation-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Acetylation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Acetylation"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Acetylation</span> </div> </a> <ul id="toc-Acetylation-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Methylation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Methylation"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.3</span> <span>Methylation</span> </div> </a> <ul id="toc-Methylation-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Interactions" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Interactions</span> </div> </a> <ul id="toc-Interactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Role_in_immune_system" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Role_in_immune_system"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Role in immune system</span> </div> </a> <ul id="toc-Role_in_immune_system-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Cancer" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Cancer"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Cancer</span> </div> </a> <button aria-controls="toc-Cancer-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Cancer subsection</span> </button> <ul id="toc-Cancer-sublist" class="vector-toc-list"> <li id="toc-Prostate" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Prostate"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>Prostate</span> </div> </a> <ul id="toc-Prostate-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Thyroid" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Thyroid"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.2</span> <span>Thyroid</span> </div> </a> <ul id="toc-Thyroid-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Leukemia" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Leukemia"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.3</span> <span>Leukemia</span> </div> </a> <ul id="toc-Leukemia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Head_and_neck" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Head_and_neck"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.4</span> <span>Head and neck</span> </div> </a> <ul id="toc-Head_and_neck-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Breast" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Breast"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.5</span> <span>Breast</span> </div> </a> <ul id="toc-Breast-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Monogenic_Behçet’s_Disease-like_conditions" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Monogenic_Behçet’s_Disease-like_conditions"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.6</span> <span>Monogenic Behçet’s Disease-like conditions</span> </div> </a> <ul id="toc-Monogenic_Behçet’s_Disease-like_conditions-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> 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<button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">For other uses, see <a href="/wiki/RELA_Corps" class="mw-redirect" title="RELA Corps">RELA Corps</a>.</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">RELA</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Protein_RELA_PDB_1bft.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/63/Protein_RELA_PDB_1bft.png/250px-Protein_RELA_PDB_1bft.png" decoding="async" width="250" height="167" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/63/Protein_RELA_PDB_1bft.png/375px-Protein_RELA_PDB_1bft.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/63/Protein_RELA_PDB_1bft.png/500px-Protein_RELA_PDB_1bft.png 2x" data-file-width="836" data-file-height="558" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=Q04207%20or%20Q04206%20or%20E9PJR1">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q04207,Q04206,E9PJR1">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4KV4">4KV4</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1NFI">1NFI</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2LSP">2LSP</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2O61">2O61</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3GUT">3GUT</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3QXY">3QXY</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3RC0">3RC0</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4KV1">4KV1</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2N22">2N22</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/9955">RELA</a></span>, NFKB3, p65, RELA proto-oncogene, NF-kB subunit, CMCU</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/164014">164014</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:103290">103290</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=32064">32064</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=RELA">RELA</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000173039">RELA - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_11.svg" class="mw-file-description" title="Chromosome 11 (human)"><img alt="Chromosome 11 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_human_chromosome_11.svg/300px-Ideogram_human_chromosome_11.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_human_chromosome_11.svg/450px-Ideogram_human_chromosome_11.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_human_chromosome_11.svg/600px-Ideogram_human_chromosome_11.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_11_(human)" class="mw-redirect" title="Chromosome 11 (human)">Chromosome 11 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_11_ideogram.svg" class="mw-file-description" title="Chromosome 11 (human)"><img alt="Chromosome 11 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/43/Human_chromosome_11_ideogram.svg/300px-Human_chromosome_11_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/43/Human_chromosome_11_ideogram.svg/450px-Human_chromosome_11_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/43/Human_chromosome_11_ideogram.svg/600px-Human_chromosome_11_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 137.56233548935px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for RELA"><img alt="Genomic location for RELA" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 143.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for RELA"><img alt="Genomic location for RELA" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">11q13.1</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">65,653,599 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">65,663,090 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_19.svg" class="mw-file-description" title="Chromosome 19 (mouse)"><img alt="Chromosome 19 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/260px-Ideogram_house_mouse_chromosome_19.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/390px-Ideogram_house_mouse_chromosome_19.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/82/Ideogram_house_mouse_chromosome_19.svg/520px-Ideogram_house_mouse_chromosome_19.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 19 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_19.svg" class="mw-file-description" title="Chromosome 19 (mouse)"><img alt="Chromosome 19 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/300px-Ideogram_of_house_mouse_chromosome_19.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/450px-Ideogram_of_house_mouse_chromosome_19.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/Ideogram_of_house_mouse_chromosome_19.svg/600px-Ideogram_of_house_mouse_chromosome_19.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 21.857186127331px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for RELA"><img alt="Genomic location for RELA" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 27.9px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for RELA"><img alt="Genomic location for RELA" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">19 A|19 4.34 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">5,687,511 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">5,698,158 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000173039">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">gastric mucosa</li><br /><li style="line-height: 137%;">popliteal artery</li><br /><li style="line-height: 137%;">tibial arteries</li><br /><li style="line-height: 137%;">left uterine tube</li><br /><li style="line-height: 137%;">cartilage tissue</li><br /><li style="line-height: 137%;">right lung</li><br /><li style="line-height: 137%;">ascending aorta</li><br /><li style="line-height: 137%;">Descending thoracic aorta</li><br /><li style="line-height: 137%;">ectocervix</li><br /><li style="line-height: 137%;">right coronary artery</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000024927">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">lactiferous gland</li><br /><li style="line-height: 137%;">choroid plexus of fourth ventricle</li><br /><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">external carotid artery</li><br /><li style="line-height: 137%;">internal carotid artery</li><br /><li style="line-height: 137%;">gastrula</li><br /><li style="line-height: 137%;">genital tubercle</li><br /><li style="line-height: 137%;">mesenteric lymph nodes</li><br /><li style="line-height: 137%;">stroma of bone marrow</li><br /><li style="line-height: 137%;">right lung</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000173039">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_RELA_201783_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/45/PBB_GE_RELA_201783_s_at_fs.png/250px-PBB_GE_RELA_201783_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/45/PBB_GE_RELA_201783_s_at_fs.png/375px-PBB_GE_RELA_201783_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/45/PBB_GE_RELA_201783_s_at_fs.png/500px-PBB_GE_RELA_201783_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_RELA_209878_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/ee/PBB_GE_RELA_209878_s_at_fs.png/250px-PBB_GE_RELA_209878_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/ee/PBB_GE_RELA_209878_s_at_fs.png/375px-PBB_GE_RELA_209878_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/ee/PBB_GE_RELA_209878_s_at_fs.png/500px-PBB_GE_RELA_209878_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/5970/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0047485">protein N-terminus binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071532">ankyrin repeat binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001228">DNA-binding transcription activator activity, RNA polymerase II-specific</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042826">histone deacetylase binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019899">enzyme binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042301">phosphate ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000978">RNA polymerase II cis-regulatory region sequence-specific DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042803">protein homodimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003682">chromatin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051059">NF-kappaB binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019901">protein kinase binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003677">DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043565">sequence-specific DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042805">actinin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046982">protein heterodimerization activity</a></li> <li><a href="https://www.wikidata.org/wiki/Q14819273" class="extiw" title="d:Q14819273">transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031490">chromatin DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031625">ubiquitin protein ligase binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016251">RNA polymerase II general transcription initiation factor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000977">RNA polymerase II transcription regulatory region sequence-specific DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003700">DNA-binding transcription factor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001227">DNA-binding transcription repressor activity, RNA polymerase II-specific</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042802">identical protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000981">DNA-binding transcription factor activity, RNA polymerase II-specific</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008134">transcription factor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044877">protein-containing complex binding</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033256">I-kappaB/NF-kappaB complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005667">transcription regulator complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071159">NF-kappaB complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005654">nucleoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005730">nucleolus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035525">NF-kappaB p50/p65 complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032991">protein-containing complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045202">synapse</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098978">glutamatergic synapse</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043200">response to amino acid</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070555">response to interleukin-1</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071354">cellular response to interleukin-6</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032570">response to progesterone</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010033">response to organic substance</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038095">Fc-epsilon receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046627">negative regulation of insulin receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051607">defense response to virus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032332">positive regulation of chondrocyte differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009887">animal organ morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035994">response to muscle stretch</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034097">response to cytokine</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042177">negative regulation of protein catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019221">cytokine-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2001237">negative regulation of extrinsic apoptotic signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009612">response to mechanical stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032495">response to muramyl dipeptide</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002223">stimulatory C-type lectin receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006351">transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032868">response to insulin</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1901223">negative regulation of NIK/NF-kappaB signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070431">nucleotide-binding oligomerization domain containing 2 signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031293">membrane protein intracellular domain proteolysis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006954">inflammatory response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016032">viral process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033590">response to cobalamin</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001942">hair follicle development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000630">positive regulation of miRNA metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006117">acetaldehyde metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035729">cellular response to hepatocyte growth factor stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071316">cellular response to nicotine</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043066">negative regulation of apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006968">cellular defense response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043278">response to morphine</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032496">response to lipopolysaccharide</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071347">cellular response to interleukin-1</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010035">response to inorganic substance</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050727">regulation of inflammatory response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051591">response to cAMP</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045892">negative regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042542">response to hydrogen peroxide</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0014040">positive regulation of Schwann cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006952">defense response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009617">response to bacterium</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0014070">response to organic cyclic compound</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007568">ageing</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008284">positive regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043123">positive regulation of I-kappaB kinase/NF-kappaB signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001889">liver development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010224">response to UV-B</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050852">T cell receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071222">cellular response to lipopolysaccharide</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032481">positive regulation of type I interferon production</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045944">positive regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070301">cellular response to hydrogen peroxide</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006355">regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033209">tumor necrosis factor-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045893">positive regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050862">positive regulation of T cell receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051092">positive regulation of NF-kappaB transcription factor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071224">cellular response to peptidoglycan</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071356">cellular response to tumor necrosis factor</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1901222">regulation of NIK/NF-kappaB signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1901224">positive regulation of NIK/NF-kappaB signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1901522">positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1902895">positive regulation of pri-miRNA transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043620">regulation of DNA-templated transcription in response to stress</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071223">cellular response to lipoteichoic acid</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000122">negative regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033234">negative regulation of protein sumoylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0061614">pri-miRNA transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1904385">cellular response to angiotensin</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070498">interleukin-1-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035924">cellular response to vascular endothelial growth factor stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1902894">negative regulation of pri-miRNA transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0099527">postsynapse to nucleus signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006325">chromatin organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007249">I-kappaB kinase/NF-kappaB signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038061">NIK/NF-kappaB signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1904996">positive regulation of leukocyte adhesion to vascular endothelial cell</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=5970&rn=1">5970</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=19697&rn=1">19697</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000173039;db=core">ENSG00000173039</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000024927;db=core">ENSMUSG00000024927</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q04206">Q04206</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q04207">Q04207</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001145138">NM_001145138</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001243984">NM_001243984</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001243985">NM_001243985</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_021975">NM_021975</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_009045">NM_009045</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001365067">NM_001365067</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001138610">NP_001138610</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001230913">NP_001230913</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001230914">NP_001230914</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_068810">NP_068810</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_033071">NP_033071</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001351996">NP_001351996</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr11:65653599-65663090">Chr 11: 65.65 – 65.66 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr19:5687511-5698158">Chr 19: 5.69 – 5.7 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q15326052" class="extiw" title="d:Q15326052">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q15326058" class="extiw" title="d:Q15326058">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Transcription factor p65</b> also known as <b>nuclear factor NF-kappa-B p65 subunit</b> is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>RELA</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid2001591_5-0" class="reference"><a href="#cite_note-pmid2001591-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>RELA, also known as p65, is a REL-associated protein involved in <a href="/wiki/NF-%CE%BAB" title="NF-κB">NF-κB</a> heterodimer formation, nuclear translocation and activation.<sup id="cite_ref-Thiel_2021_6-0" class="reference"><a href="#cite_note-Thiel_2021-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> NF-κB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, <a href="/wiki/Chemotaxis" title="Chemotaxis">chemotaxis</a>, etc. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NF-κB activation. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Gene_and_expression">Gene and expression</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=1" title="Edit section: Gene and expression"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>RELA, or v-rel avian reticuloendotheliosis viral oncogene homolog A, is also known as p65 or NFKB3.<sup id="cite_ref-urlRELA_v-rel_avian_reticuloendotheliosis_viral_oncogene_homolog_A_[Homo_sapiens_(human)]_-_Gene_-_NCBI_7-0" class="reference"><a href="#cite_note-urlRELA_v-rel_avian_reticuloendotheliosis_viral_oncogene_homolog_A_[Homo_sapiens_(human)]_-_Gene_-_NCBI-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> It is located on chromosome 11 q13, and its nucleotide sequence is 1473 nucleotide long.<sup id="cite_ref-urlHomo_sapiens_p65_gene_for_p65_subunit_of_transcription_factor_NF-kappa_-_Nucleotide_-_NCBI_8-0" class="reference"><a href="#cite_note-urlHomo_sapiens_p65_gene_for_p65_subunit_of_transcription_factor_NF-kappa_-_Nucleotide_-_NCBI-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> RELA protein has four isoforms, the longest and the predominant one being 551 amino acids. RELA is expressed alongside p50 in various cell types, including epithelial/endothelial cells and neuronal tissues.<sup id="cite_ref-Li_2002_9-0" class="reference"><a href="#cite_note-Li_2002-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=2" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>RELA is one member of the NF-κB family, one of the essential transcription factors under intensive study. Seven proteins encoded by five genes are involved in the NF-κB complex, namely <a href="/wiki/NFKB1" title="NFKB1">p105</a>, <a href="/wiki/NFKB2" title="NFKB2">p100</a>, <a href="/wiki/NFKB1" title="NFKB1">p50</a>, <a href="/wiki/NFKB2" title="NFKB2">p52</a>, RELA, <a href="/wiki/REL" title="REL">c-REL</a> and <a href="/wiki/RELB" title="RELB">RELB</a>.<sup id="cite_ref-Chen_2004_10-0" class="reference"><a href="#cite_note-Chen_2004-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Like other proteins in this complex, RELA contains a N-terminal REL-homology domain (RHD), and also a C-terminal transactivation domain (TAD). RHD is involved in DNA binding, dimerization and NF-κB/REL inhibitor interaction. On the other hand, TAD is responsible for interacting with the basal transcription complex including many coactivators of transcription such as <a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TBP</a>, <a href="/wiki/Transcription_factor_II_B" title="Transcription factor II B">TFIIB</a> and CREB-CBP.<sup id="cite_ref-Chen_2004_10-1" class="reference"><a href="#cite_note-Chen_2004-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> RELA and p50 is the mostly commonly found heterodimer complex among NF-κB homodimers and heterodimers, and is the functional component participating in nuclear translocation and activation of NF-κB. </p><p>RELA is a 65 kDa protein.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Phosphorylation">Phosphorylation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=3" title="Edit section: Phosphorylation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Phosphorylation of RELA plays a key role in regulating NF-κB activation and function. Subsequent to NF-κB nuclear translocation, RELA undergoes site-specific post-translational modifications to further enhance the NF-κB function as a transcription factor. RELA can either be phosphorylated in the RHD region or the TAD region, attracting different interaction partners. Triggered by lipopolysaccharide (LPS), protein kinase A (PKA) specifically phosphorylates serine 276 in the RHD domain in the cytoplasm, controlling NF-κB DNA-binding and oligomerization.<sup id="cite_ref-pmid9660950_12-0" class="reference"><a href="#cite_note-pmid9660950-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> On the other hand, mitogen and stress-activated kinase 1 (<a href="/wiki/RPS6KA5" title="RPS6KA5">MSK1</a>) are also able to phosphorylate RELA at residue 276 under <a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">TNFα</a> induction in the nucleus, increasing NF-κB response at the transcriptional level.<sup id="cite_ref-pmid12628924_13-0" class="reference"><a href="#cite_note-pmid12628924-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> Phosphorylation of serine 311 by protein kinase C zeta type (<a href="/wiki/Protein_kinase_C_zeta_type" title="Protein kinase C zeta type">PKCζ</a>) serves the same purpose.<sup id="cite_ref-pmid12881425_14-0" class="reference"><a href="#cite_note-pmid12881425-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Two residues in the TAD region are targeted by phosphorylation. After IL-1or TNFα stimulation, serine 529 is phosphorylated by casein kinase II (<a href="/wiki/Casein_kinase_2" title="Casein kinase 2">CKII</a>),<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> while serine 536 is phosphorylated by IκB kinases (IKKs). In response to DNA damage, ribosomal subunit kinase-1 (RSK1) also has the ability to phosphorylate RELA at serine 536 in a p53-dependent manner.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> A couple of other kinases are also able to phosphorylate RELA at different conditions, including glycogen-synthase kinase-3β (<a href="/wiki/GSK3B" class="mw-redirect" title="GSK3B">GSK3β</a>), AKT/phosphatidylinositol 3-kinase (PI3K) and NF-κB activating kinase (NAK, i.e. TANK-binding kinase-1 (<a href="/wiki/TANK-binding_kinase_1" title="TANK-binding kinase 1">TBK1</a>) and <a href="/wiki/TRAF2" title="TRAF2">TRAF2</a>-associated kinase (T2K)).<sup id="cite_ref-Chen_2004_10-2" class="reference"><a href="#cite_note-Chen_2004-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> The fact that RELA can be modified by a collection of kinases via phosphorylation at different sites/regions within the protein under different stimulations might suggest a synergistic effect of these modifications. Phosphorylation at these sites enhances NF-κB transcriptional response via tightened binding to transcription coactivators. For example, <a href="/wiki/CREB-binding_protein" title="CREB-binding protein">CBP</a> and <a href="/wiki/EP300" title="EP300">p300</a> binding to RELA are enhanced when serine 276 or 311 is phosphorylated.<sup id="cite_ref-Chen_2004_10-3" class="reference"><a href="#cite_note-Chen_2004-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Status of several phosphorylation sites determines RELA stability mediated by the ubiquitin-mediated proteolysis.<sup id="cite_ref-pmid14690596_17-0" class="reference"><a href="#cite_note-pmid14690596-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid19270718_18-0" class="reference"><a href="#cite_note-pmid19270718-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid19911008_19-0" class="reference"><a href="#cite_note-pmid19911008-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> Cell-type-specific phosphorylation is also observed for RELA. Multiple-site phosphorylation is common in endothelial cells, and different cell types may contain different stimuli, leading to targeted phosphorylation of RELA by different kinases. For instance, IKK2 is found to be mainly responsible for phosphorylating serine 536 in monocytes and macrophages, or in CD40 receptor binding in hepatic stellate cells.<sup id="cite_ref-Li_2002_9-1" class="reference"><a href="#cite_note-Li_2002-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> <a href="/wiki/CHUK" title="CHUK">IKK1</a> functions as the major kinase phosphorylating serine 536 under different stimuli, such as the ligand activation of the lymphotoxin-β receptor (LTβR).<sup id="cite_ref-Li_2002_9-2" class="reference"><a href="#cite_note-Li_2002-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Acetylation">Acetylation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=4" title="Edit section: Acetylation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In vivo studies revealed that RELA is also under acetylation modification in the nucleus, which is just as important as phosphorylation as a post-translational modification of proteins. Lysines 218, 221 and 310 are acetylation targets within RELA, and response to acetylation is site-specific.<sup id="cite_ref-Chen_2004_10-4" class="reference"><a href="#cite_note-Chen_2004-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> For instance, lysine 221 acetylation facilitates RELA dissociation from IκBα and enhances its DNA-binding affinity. Lysine 310 acetylation is indispensable for the full transcriptional activity of RELA, but does not affect its DNA-binding ability. Hypothesis about RELA acetylation suggests acetylation aids its subsequent recognition by transcriptional co-activators with bromodomains, which are specialized in recognizing acetylated lysine residues.<sup id="cite_ref-Chen_2004_10-5" class="reference"><a href="#cite_note-Chen_2004-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Lysine 122 and 123 acetylation are found to be negatively correlated with RELA transcriptional activation. Unknown mechanisms mediate the acetylation of RELA possibly using p300/CBP and p300/CBP factor associated coactivators under TNFα or phorbol myristate acetate (PMF) stimulation both in vivo and in vitro.<sup id="cite_ref-Chen_2004_10-6" class="reference"><a href="#cite_note-Chen_2004-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> RELA is also under the control of deacetylation via HDAC, and HDAC3 is the mediator of this process both in vivo and in vitro.<sup id="cite_ref-Li_2002_9-3" class="reference"><a href="#cite_note-Li_2002-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Chen_2004_10-7" class="reference"><a href="#cite_note-Chen_2004-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Methylation">Methylation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=5" title="Edit section: Methylation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Methylation of lysine 218 and 221 together or lysine 37 alone in the RHD domain of RELA can lead to increased response to cytokines such as IL-1 in mammalian cell culture.<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=6" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>As the prototypical heterodimer complex member of the NF-κB, together with p50, RELA/p65 interacts with various proteins in both the cytoplasm and in the nucleus during the process of classical NF-κB activation and nuclear translocation. In the inactive state, RELA/p50 complex is mainly sequestered by <a href="/wiki/I%CE%BAB%CE%B1" title="IκBα">IκBα</a> in the cytosol. TNFα, <a href="/wiki/Lipopolysaccharide" title="Lipopolysaccharide">LPS</a> and other factors serve as activation inducers, followed by phosphorylation at residue 32 and 36 of IκBα, leading to rapid degradation of IκBα via the ubiquitin-proteasomal system and subsequent release of RELA/p50 complex.<sup id="cite_ref-Chen_2004_10-8" class="reference"><a href="#cite_note-Chen_2004-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> RELA nuclear localization signal used to be sequestered by IκBα is now exposed, and rapid translocation of the NF-κB occurs. In parallel, there is a non-classical NF-κB activation pathway involving the proteolytic cleavage of p100 into p52 instead of p50. This process does not require RELA, hence will not be discussed in detail here.<sup id="cite_ref-Chen_2004_10-9" class="reference"><a href="#cite_note-Chen_2004-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> After NF-κB nuclear localization due to TNFα stimulation, p50/RELA heterodimer will function as a transcription factor and bind to a variety of genes involved in all kinds of biological processes, such as leukocyte activation/chemotaxis, negative regulation of TNFIKK pathway, cellular metabolism, antigen processing, just to name a few .<sup id="cite_ref-Nowak_2008_21-0" class="reference"><a href="#cite_note-Nowak_2008-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> Phosphorylation of RELA at different residues also enables its interaction with CDKs and P-TEFb. Phosphorylation at serine 276 in RELA allows its interaction with P-TEFb containing <a href="/wiki/Cyclin-dependent_kinase_9" title="Cyclin-dependent kinase 9">CDK9</a> and cyclin T1 subunits, and phospho-ser276 RELA-P-TEFb complex is necessary for <a href="/wiki/Interleukin_8" title="Interleukin 8">IL-8</a> and Gro-β activation.<sup id="cite_ref-Nowak_2008_21-1" class="reference"><a href="#cite_note-Nowak_2008-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> Another mechanism is involved in the activation of genes preloaded with Pol II in a RELA serine 276 phosphorylation independent manner. </p><p>RELA has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/APBA2" title="APBA2">APBA2</a>,<sup id="cite_ref-pmid10777610_22-0" class="reference"><a href="#cite_note-pmid10777610-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor" title="Aryl hydrocarbon receptor">AHR</a>,<sup id="cite_ref-pmid11114727_23-0" class="reference"><a href="#cite_note-pmid11114727-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12181450_24-0" class="reference"><a href="#cite_note-pmid12181450-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/ASCC3" title="ASCC3">ASCC3</a>,<sup id="cite_ref-pmid12077347_25-0" class="reference"><a href="#cite_note-pmid12077347-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/BRCA1" title="BRCA1">BRCA1</a>,<sup id="cite_ref-pmid12700228_26-0" class="reference"><a href="#cite_note-pmid12700228-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/BTRC_(gene)" title="BTRC (gene)">BTRC</a>,<sup id="cite_ref-pmid9990853_27-0" class="reference"><a href="#cite_note-pmid9990853-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/C-Fos" class="mw-redirect" title="C-Fos">c-Fos</a>,<sup id="cite_ref-pmid10488148_28-0" class="reference"><a href="#cite_note-pmid10488148-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/C-Jun" class="mw-redirect" title="C-Jun">c-Jun</a>,<sup id="cite_ref-pmid10488148_28-1" class="reference"><a href="#cite_note-pmid10488148-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/C22orf25" class="mw-redirect" title="C22orf25">C22orf25</a>,<sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CDK9" class="mw-redirect" title="CDK9">CDK9</a>,<sup id="cite_ref-pmid12173051_30-0" class="reference"><a href="#cite_note-pmid12173051-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CEBPB" title="CEBPB">CEBPB</a>,<sup id="cite_ref-pmid12707271_31-0" class="reference"><a href="#cite_note-pmid12707271-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9570146_32-0" class="reference"><a href="#cite_note-pmid9570146-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CEBPE" title="CEBPE">CEBPE</a>,<sup id="cite_ref-pmid17255362_33-0" class="reference"><a href="#cite_note-pmid17255362-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CREB_binding_protein" class="mw-redirect" title="CREB binding protein">CREBBP</a>,<sup id="cite_ref-pmid15140884_34-0" class="reference"><a href="#cite_note-pmid15140884-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11931769_35-0" class="reference"><a href="#cite_note-pmid11931769-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9548485_36-0" class="reference"><a href="#cite_note-pmid9548485-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9482849_37-0" class="reference"><a href="#cite_note-pmid9482849-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9096323_38-0" class="reference"><a href="#cite_note-pmid9096323-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid22261743_39-0" class="reference"><a href="#cite_note-pmid22261743-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Casein_kinase_2,_alpha_1" title="Casein kinase 2, alpha 1">CSNK2A1</a>,<sup id="cite_ref-pmid10938077_40-0" class="reference"><a href="#cite_note-pmid10938077-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CSNK2A2" title="CSNK2A2">CSNK2A2</a>,<sup id="cite_ref-pmid10938077_40-1" class="reference"><a href="#cite_note-pmid10938077-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/DHX9" class="mw-redirect" title="DHX9">DHX9</a>,<sup id="cite_ref-pmid15355351_41-0" class="reference"><a href="#cite_note-pmid15355351-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/EP300" title="EP300">EP300</a>,<sup id="cite_ref-pmid9096323_38-1" class="reference"><a href="#cite_note-pmid9096323-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12419806_42-0" class="reference"><a href="#cite_note-pmid12419806-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/ETHE1" title="ETHE1">ETHE1</a>,<sup id="cite_ref-pmid12398897_43-0" class="reference"><a href="#cite_note-pmid12398897-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/FUS_(gene)" class="mw-redirect" title="FUS (gene)">FUS</a>,<sup id="cite_ref-pmid11278855_44-0" class="reference"><a href="#cite_note-pmid11278855-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/GCN5L2" class="mw-redirect" title="GCN5L2">GCN5</a>,<sup id="cite_ref-pmid19339690_45-0" class="reference"><a href="#cite_note-pmid19339690-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/HDAC1" title="HDAC1">HDAC1</a>,<sup id="cite_ref-pmid11931769_35-1" class="reference"><a href="#cite_note-pmid11931769-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12419806_42-1" class="reference"><a href="#cite_note-pmid12419806-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11564889_46-0" class="reference"><a href="#cite_note-pmid11564889-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Histone_deacetylase_2" title="Histone deacetylase 2">HDAC2</a>,<sup id="cite_ref-pmid12419806_42-2" class="reference"><a href="#cite_note-pmid12419806-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12138131_47-0" class="reference"><a href="#cite_note-pmid12138131-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/HDAC3" title="HDAC3">HDAC3</a>,<sup id="cite_ref-pmid11533489_48-0" class="reference"><a href="#cite_note-pmid11533489-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/ING4" title="ING4">ING4</a>,<sup id="cite_ref-pmid15029197_49-0" class="reference"><a href="#cite_note-pmid15029197-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/I%CE%BAB%CE%B1" title="IκBα">IκBα</a>,<sup id="cite_ref-pmid9990853_27-1" class="reference"><a href="#cite_note-pmid9990853-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12419806_42-3" class="reference"><a href="#cite_note-pmid12419806-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11533489_48-1" class="reference"><a href="#cite_note-pmid11533489-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11313474_50-0" class="reference"><a href="#cite_note-pmid11313474-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8139561_51-0" class="reference"><a href="#cite_note-pmid8139561-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9738011_52-0" class="reference"><a href="#cite_note-pmid9738011-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9751059_53-0" class="reference"><a href="#cite_note-pmid9751059-53"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/KLF5" title="KLF5">KLF5</a>,<sup id="cite_ref-pmid25197166_54-0" class="reference"><a href="#cite_note-pmid25197166-54"><span class="cite-bracket">[</span>54<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MDM2" class="mw-redirect" title="MDM2">MDM2</a>,<sup id="cite_ref-pmid23839035_55-0" class="reference"><a href="#cite_note-pmid23839035-55"><span class="cite-bracket">[</span>55<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MEN1" title="MEN1">MEN1</a>,<sup id="cite_ref-pmid11526476_56-0" class="reference"><a href="#cite_note-pmid11526476-56"><span class="cite-bracket">[</span>56<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/RPS6KA5" title="RPS6KA5">MSK1</a>,<sup id="cite_ref-pmid12628924_13-1" class="reference"><a href="#cite_note-pmid12628924-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MTPN" title="MTPN">MTPN</a>,<sup id="cite_ref-pmid11971907_57-0" class="reference"><a href="#cite_note-pmid11971907-57"><span class="cite-bracket">[</span>57<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Neutrophil_cytosolic_factor_1" title="Neutrophil cytosolic factor 1">NCF1</a>,<sup id="cite_ref-pmid12618429_58-0" class="reference"><a href="#cite_note-pmid12618429-58"><span class="cite-bracket">[</span>58<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/NFKB1" title="NFKB1">NFKB1</a>,<sup id="cite_ref-pmid14743216_59-0" class="reference"><a href="#cite_note-pmid14743216-59"><span class="cite-bracket">[</span>59<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8798655_60-0" class="reference"><a href="#cite_note-pmid8798655-60"><span class="cite-bracket">[</span>60<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/NFKB2" title="NFKB2">NFKB2</a>,<sup id="cite_ref-pmid14743216_59-1" class="reference"><a href="#cite_note-pmid14743216-59"><span class="cite-bracket">[</span>59<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8413211_61-0" class="reference"><a href="#cite_note-pmid8413211-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/NFKBIB" title="NFKBIB">NFKBIB</a>,<sup id="cite_ref-pmid12672800_62-0" class="reference"><a href="#cite_note-pmid12672800-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8816457_63-0" class="reference"><a href="#cite_note-pmid8816457-63"><span class="cite-bracket">[</span>63<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/NFKBIE" title="NFKBIE">NFKBIE</a>,<sup id="cite_ref-pmid9315679_64-0" class="reference"><a href="#cite_note-pmid9315679-64"><span class="cite-bracket">[</span>64<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Glucocorticoid_receptor" title="Glucocorticoid receptor">NR3C1</a>,<sup id="cite_ref-pmid8290595_65-0" class="reference"><a href="#cite_note-pmid8290595-65"><span class="cite-bracket">[</span>65<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10995388_66-0" class="reference"><a href="#cite_note-pmid10995388-66"><span class="cite-bracket">[</span>66<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid7659084_67-0" class="reference"><a href="#cite_note-pmid7659084-67"><span class="cite-bracket">[</span>67<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Nuclear_receptor_co-repressor_2" title="Nuclear receptor co-repressor 2">NCOR2</a>,<sup id="cite_ref-pmid12589049_68-0" class="reference"><a href="#cite_note-pmid12589049-68"><span class="cite-bracket">[</span>68<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10777532_69-0" class="reference"><a href="#cite_note-pmid10777532-69"><span class="cite-bracket">[</span>69<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PARP1" title="PARP1">PARP1</a>,<sup id="cite_ref-pmid11590148_70-0" class="reference"><a href="#cite_note-pmid11590148-70"><span class="cite-bracket">[</span>70<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PDLIM2" title="PDLIM2">PDLIM2</a>,<sup id="cite_ref-pmid17468759_71-0" class="reference"><a href="#cite_note-pmid17468759-71"><span class="cite-bracket">[</span>71<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PIAS3" title="PIAS3">PIAS3</a>,<sup id="cite_ref-pmid15140884_34-1" class="reference"><a href="#cite_note-pmid15140884-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PIM1" title="PIM1">PIM1</a>,<sup id="cite_ref-pmid19911008_19-1" class="reference"><a href="#cite_note-pmid19911008-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PIN1" title="PIN1">PIN1</a>,<sup id="cite_ref-pmid14690596_17-1" class="reference"><a href="#cite_note-pmid14690596-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Protein_kinase_A" title="Protein kinase A">PKA</a>,<sup id="cite_ref-pmid20562110_72-0" class="reference"><a href="#cite_note-pmid20562110-72"><span class="cite-bracket">[</span>72<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/POU2F1" title="POU2F1">POU2F1</a>,<sup id="cite_ref-pmid12019209_73-0" class="reference"><a href="#cite_note-pmid12019209-73"><span class="cite-bracket">[</span>73<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor_gamma" title="Peroxisome proliferator-activated receptor gamma">PPARG</a>,<sup id="cite_ref-pmid23250430_74-0" class="reference"><a href="#cite_note-pmid23250430-74"><span class="cite-bracket">[</span>74<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PPP1R13L" title="PPP1R13L">PPP1R13L</a>,<sup id="cite_ref-pmid10336463_75-0" class="reference"><a href="#cite_note-pmid10336463-75"><span class="cite-bracket">[</span>75<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12134007_76-0" class="reference"><a href="#cite_note-pmid12134007-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Protein_kinase_M%CE%B6" class="mw-redirect" title="Protein kinase Mζ">PRKCZ</a>,<sup id="cite_ref-pmid11684013_77-0" class="reference"><a href="#cite_note-pmid11684013-77"><span class="cite-bracket">[</span>77<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/REL" title="REL">REL</a>,<sup id="cite_ref-pmid8139561_51-1" class="reference"><a href="#cite_note-pmid8139561-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid14743216_59-2" class="reference"><a href="#cite_note-pmid14743216-59"><span class="cite-bracket">[</span>59<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11967310_78-0" class="reference"><a href="#cite_note-pmid11967310-78"><span class="cite-bracket">[</span>78<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/RFC1" title="RFC1">RFC1</a>,<sup id="cite_ref-pmid12509469_79-0" class="reference"><a href="#cite_note-pmid12509469-79"><span class="cite-bracket">[</span>79<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/RNF25" title="RNF25">RNF25</a>,<sup id="cite_ref-pmid12748188_80-0" class="reference"><a href="#cite_note-pmid12748188-80"><span class="cite-bracket">[</span>80<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/SIRT1" class="mw-redirect" title="SIRT1">SIRT1</a>,<sup id="cite_ref-pmid15152190_81-0" class="reference"><a href="#cite_note-pmid15152190-81"><span class="cite-bracket">[</span>81<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Suppressor_of_cytokine_signaling_1" title="Suppressor of cytokine signaling 1">SOCS1</a>,<sup id="cite_ref-pmid14690596_17-2" class="reference"><a href="#cite_note-pmid14690596-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid21084693_82-0" class="reference"><a href="#cite_note-pmid21084693-82"><span class="cite-bracket">[</span>82<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid17183367_83-0" class="reference"><a href="#cite_note-pmid17183367-83"><span class="cite-bracket">[</span>83<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Sp1_transcription_factor" class="mw-redirect" title="Sp1 transcription factor">SP1</a>,<sup id="cite_ref-pmid12055073_84-0" class="reference"><a href="#cite_note-pmid12055073-84"><span class="cite-bracket">[</span>84<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid7933095_85-0" class="reference"><a href="#cite_note-pmid7933095-85"><span class="cite-bracket">[</span>85<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/STAT3" title="STAT3">STAT3</a>,<sup id="cite_ref-pmid12057007_86-0" class="reference"><a href="#cite_note-pmid12057007-86"><span class="cite-bracket">[</span>86<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid20546595_87-0" class="reference"><a href="#cite_note-pmid20546595-87"><span class="cite-bracket">[</span>87<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/TAF4B" title="TAF4B">TAF4B</a>,<sup id="cite_ref-pmid9724652_88-0" class="reference"><a href="#cite_note-pmid9724652-88"><span class="cite-bracket">[</span>88<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TBP</a>,<sup id="cite_ref-pmid9584164_89-0" class="reference"><a href="#cite_note-pmid9584164-89"><span class="cite-bracket">[</span>89<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid7706261_90-0" class="reference"><a href="#cite_note-pmid7706261-90"><span class="cite-bracket">[</span>90<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/TP53" class="mw-redirect" title="TP53">TP53</a>,<sup id="cite_ref-pmid20546595_87-1" class="reference"><a href="#cite_note-pmid20546595-87"><span class="cite-bracket">[</span>87<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/TRIB3" title="TRIB3">TRIB3</a>.<sup id="cite_ref-pmid12736262_91-0" class="reference"><a href="#cite_note-pmid12736262-91"><span class="cite-bracket">[</span>91<span class="cite-bracket">]</span></a></sup></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="Role_in_immune_system">Role in immune system</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=7" title="Edit section: Role in immune system"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Gene knockout of NF-κB genes via homologous recombination in mice showed the role of these components in innate and adaptive immune responses. RELA knockout mice is embryonic lethal due to liver apoptosis.<sup id="cite_ref-Li_2002_9-4" class="reference"><a href="#cite_note-Li_2002-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Lymphocyte activation failure is also observed, suggesting that RELA is indispensable in the proper development of the immune system. In comparison, deletion of other REL-related genes will not cause embryonic development failure, though different levels of defects are also noted.<sup id="cite_ref-Li_2002_9-5" class="reference"><a href="#cite_note-Li_2002-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The fact that cytokines such as TNFα and IL-1 can stimulate the activation of RELA also supports its participation in immune response. In general, RELA participates in adaptive immunity and responses to invading pathogens via NF-κB activation. Mice without individual NF-κB proteins are deficient in B- and T-cell activation and proliferation, cytokine production and isotype switching.<sup id="cite_ref-Li_2002_9-6" class="reference"><a href="#cite_note-Li_2002-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Mutations in RELA is found responsible for inflammatory bowel disease as well.<sup id="cite_ref-Li_2002_9-7" class="reference"><a href="#cite_note-Li_2002-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Cancer">Cancer</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=8" title="Edit section: Cancer"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>NF-κB/RELA activation has been found to be correlated with cancer development,<sup id="cite_ref-pmid30240635_92-0" class="reference"><a href="#cite_note-pmid30240635-92"><span class="cite-bracket">[</span>92<span class="cite-bracket">]</span></a></sup> suggesting the potential of RELA as a cancer biomarker.<sup id="cite_ref-pmid29063976_93-0" class="reference"><a href="#cite_note-pmid29063976-93"><span class="cite-bracket">[</span>93<span class="cite-bracket">]</span></a></sup> Specific modification patterns of RELA have also been observed in many cancer types.<sup id="cite_ref-pmid30723172_94-0" class="reference"><a href="#cite_note-pmid30723172-94"><span class="cite-bracket">[</span>94<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid28681591_95-0" class="reference"><a href="#cite_note-pmid28681591-95"><span class="cite-bracket">[</span>95<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Prostate">Prostate</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=9" title="Edit section: Prostate"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>RELA may have a potential role as biomarker for prostate cancer progression and metastases, as suggested by the association found between RELA nuclear localization and prostate cancer aggressiveness and biochemical recurrence.<sup id="cite_ref-pmid23541563_96-0" class="reference"><a href="#cite_note-pmid23541563-96"><span class="cite-bracket">[</span>96<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Thyroid">Thyroid</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=10" title="Edit section: Thyroid"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Strong correlation between nuclear localization of RELA and clinicopathological parameters for papillary thyroid carcinoma (PTC), suggesting the role of NF-κB activation in tumor growth and aggressiveness in PTC.<sup id="cite_ref-pmid23528368_97-0" class="reference"><a href="#cite_note-pmid23528368-97"><span class="cite-bracket">[</span>97<span class="cite-bracket">]</span></a></sup> Other than usage as an biomarker, serine 536 phosphorylation in RELA is also correlated with nuclear translocation and the expression of some transactivating genes such as <a href="/wiki/Prostaglandin-endoperoxide_synthase_2" class="mw-redirect" title="Prostaglandin-endoperoxide synthase 2">COX-2</a>, IL-8 and GST-pi in follicular thyroid carcinomas via morphoproteomic analysis.<sup id="cite_ref-pmid22558476_98-0" class="reference"><a href="#cite_note-pmid22558476-98"><span class="cite-bracket">[</span>98<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Leukemia">Leukemia</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=11" title="Edit section: Leukemia"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Mutations in the transactivation domain of RELA can lead to decrease in transactivating ability and this mutation can be found in lymphoid neoplasia.<sup id="cite_ref-pmid9047386_99-0" class="reference"><a href="#cite_note-pmid9047386-99"><span class="cite-bracket">[</span>99<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Head_and_neck">Head and neck</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=12" title="Edit section: Head and neck"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Nuclear localization of NF-κB/RELA is positively correlated with tumor <a href="/wiki/Micrometastasis" title="Micrometastasis">micrometastases</a> into lymph and blood and negatively correlated with patient survival outcome in patients with head and neck squamous cell carcinoma (HNSCC).<sup id="cite_ref-pmid23664323_100-0" class="reference"><a href="#cite_note-pmid23664323-100"><span class="cite-bracket">[</span>100<span class="cite-bracket">]</span></a></sup> This suggests a role of NF-κB/RELA as a possible target for targeted-therapy. </p> <div class="mw-heading mw-heading3"><h3 id="Breast">Breast</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=13" title="Edit section: Breast"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>There is both a physical and a functional association between RELA and aryl hydrocarbon receptor (AhR), and the subsequent activation of c-myc gene transcription in breast cancer cells.<sup id="cite_ref-pmid11114727_23-1" class="reference"><a href="#cite_note-pmid11114727-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> Another paper reported interactions between estrogen receptor (ER) and NF-κB members, including p50 and RELA. It is shown that ERα interacts with both p50 and RELA in vitro and in vivo, and RELA antibody can reduce ERα:ERE complex formation. The paper claims a mutual repression between ER and NF-κB.<sup id="cite_ref-pmid19350539_101-0" class="reference"><a href="#cite_note-pmid19350539-101"><span class="cite-bracket">[</span>101<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Monogenic_Behçet’s_Disease-like_conditions"><span id="Monogenic_Beh.C3.A7et.E2.80.99s_Disease-like_conditions"></span>Monogenic Behçet’s Disease-like conditions</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=14" title="Edit section: Monogenic Behçet’s Disease-like conditions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Beh%C3%A7et%27s_disease" title="Behçet's disease">Behçet's disease</a>-like conditions are increasingly recognized and to date predominantly involve loss-of-function variants in <i><a href="/wiki/TNFAIP3" title="TNFAIP3">TNFAIP3</a></i>. However, a RELA mutation that results in truncated protein variant has been reported to cause severe <a href="/wiki/Autoinflammatory_disease" class="mw-redirect" title="Autoinflammatory disease">autoinflammatory disease</a> due to impaired <a href="/wiki/NF-%CE%BAB" title="NF-κB">NF-κB</a> signaling and increased apoptosis.<sup id="cite_ref-102" class="reference"><a href="#cite_note-102"><span class="cite-bracket">[</span>102<span class="cite-bracket">]</span></a></sup> The phenotypes associated with this disease include <a href="/wiki/Mouth_ulcer" title="Mouth ulcer">mucocutaneous ulcerative</a> syndrome and <a href="/wiki/Neuromyelitis_optica" class="mw-redirect" title="Neuromyelitis optica">neuromyelitis optica</a> (NMO). </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=RELA&action=edit&section=15" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output 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0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Antiestrogen+resistance+in+breast+cancer+and+the+role+of+estrogen+receptor+signaling&rft.volume=22&rft.issue=47&rft.pages=7316-7339&rft.date=2003-10&rft_id=info%3Adoi%2F10.1038%2Fsj.onc.1206937&rft_id=info%3Apmid%2F14576841&rft.aulast=Clarke&rft.aufirst=R&rft.au=Liu%2C+MC&rft.au=Bouker%2C+KB&rft.au=Gu%2C+Z&rft.au=Lee%2C+RY&rft.au=Zhu%2C+Y&rft.au=Skaar%2C+TC&rft.au=Gomez%2C+B&rft.au=O%27Brien%2C+K&rft.au=Wang%2C+Y&rft.au=Hilakivi-Clarke%2C+LA&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252Fsj.onc.1206937&rfr_id=info%3Asid%2Fen.wikipedia.org%3ARELA" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBhattGhosh2014" class="citation journal cs1">Bhatt D, Ghosh S (Feb 2014). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933792">"Regulation of the NF-κB-Mediated Transcription of Inflammatory Genes"</a>. <i>Frontiers in Immunology</i>. <b>5</b> (71): 71. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.3389%2Ffimmu.2014.00071">10.3389/fimmu.2014.00071</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933792">3933792</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24611065">24611065</a>.</cite><span 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2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1bft</b>: STRUCTURE OF NF-KB P50 HOMODIMER BOUND TO A KB SITE</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1ikn_EBI.jpg" class="mw-file-description" title="1ikn: IKAPPABALPHA/NF-KAPPAB COMPLEX"><img alt="1ikn: IKAPPABALPHA/NF-KAPPAB COMPLEX" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f0/PDB_1ikn_EBI.jpg/180px-PDB_1ikn_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f0/PDB_1ikn_EBI.jpg/270px-PDB_1ikn_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f0/PDB_1ikn_EBI.jpg/360px-PDB_1ikn_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1ikn</b>: IKAPPABALPHA/NF-KAPPAB COMPLEX</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1k3z_EBI.jpg" class="mw-file-description" title="1k3z: X-ray crystal structure of the IkBb/NF-kB p65 homodimer complex"><img alt="1k3z: X-ray crystal structure of the IkBb/NF-kB p65 homodimer complex" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/PDB_1k3z_EBI.jpg/180px-PDB_1k3z_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/PDB_1k3z_EBI.jpg/270px-PDB_1k3z_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/61/PDB_1k3z_EBI.jpg/360px-PDB_1k3z_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1k3z</b>: X-ray crystal structure of the IkBb/NF-kB p65 homodimer complex</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1le5_EBI.jpg" class="mw-file-description" title="1le5: Crystal structure of a NF-kB heterodimer bound to an IFNb-kB"><img alt="1le5: Crystal structure of a NF-kB heterodimer bound to an IFNb-kB" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a3/PDB_1le5_EBI.jpg/180px-PDB_1le5_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a3/PDB_1le5_EBI.jpg/270px-PDB_1le5_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a3/PDB_1le5_EBI.jpg/360px-PDB_1le5_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1le5</b>: Crystal structure of a NF-kB heterodimer bound to an IFNb-kB</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1le9_EBI.jpg" class="mw-file-description" title="1le9: Crystal structure of a NF-kB heterodimer bound to the Ig/HIV-kB siti"><img alt="1le9: Crystal structure of a NF-kB heterodimer bound to the Ig/HIV-kB siti" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7d/PDB_1le9_EBI.jpg/180px-PDB_1le9_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7d/PDB_1le9_EBI.jpg/270px-PDB_1le9_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7d/PDB_1le9_EBI.jpg/360px-PDB_1le9_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1le9</b>: Crystal structure of a NF-kB heterodimer bound to the Ig/HIV-kB siti</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1lei_EBI.jpg" class="mw-file-description" title="1lei: The kB DNA sequence from the HLV-LTR functions as an allosteric regulator of HIV transcription"><img alt="1lei: The kB DNA sequence from the HLV-LTR functions as an allosteric regulator of HIV transcription" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/ed/PDB_1lei_EBI.jpg/180px-PDB_1lei_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/ed/PDB_1lei_EBI.jpg/270px-PDB_1lei_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/ed/PDB_1lei_EBI.jpg/360px-PDB_1lei_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1lei</b>: The kB DNA sequence from the HLV-LTR functions as an allosteric regulator of HIV transcription</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1my5_EBI.jpg" class="mw-file-description" title="1my5: NF-kappaB p65 subunit dimerization domain homodimer"><img alt="1my5: NF-kappaB p65 subunit dimerization domain homodimer" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/44/PDB_1my5_EBI.jpg/180px-PDB_1my5_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/44/PDB_1my5_EBI.jpg/270px-PDB_1my5_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/44/PDB_1my5_EBI.jpg/360px-PDB_1my5_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1my5</b>: NF-kappaB p65 subunit dimerization domain homodimer</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1my7_EBI.jpg" class="mw-file-description" title="1my7: NF-kappaB p65 subunit dimerization domain homodimer N202R mutation"><img alt="1my7: NF-kappaB p65 subunit dimerization domain homodimer N202R mutation" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/cc/PDB_1my7_EBI.jpg/180px-PDB_1my7_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/cc/PDB_1my7_EBI.jpg/270px-PDB_1my7_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/cc/PDB_1my7_EBI.jpg/360px-PDB_1my7_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1my7</b>: NF-kappaB p65 subunit dimerization domain homodimer N202R mutation</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1nfi_EBI.jpg" class="mw-file-description" title="1nfi: I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX"><img alt="1nfi: I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4d/PDB_1nfi_EBI.jpg/180px-PDB_1nfi_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4d/PDB_1nfi_EBI.jpg/270px-PDB_1nfi_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4d/PDB_1nfi_EBI.jpg/360px-PDB_1nfi_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1nfi</b>: I-KAPPA-B-ALPHA/NF-KAPPA-B COMPLEX</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1oy3_EBI.jpg" class="mw-file-description" title="1oy3: CRYSTAL STRUCTURE OF AN IKBBETA/NF-KB P65 HOMODIMER COMPLEX"><img alt="1oy3: CRYSTAL STRUCTURE OF AN IKBBETA/NF-KB P65 HOMODIMER COMPLEX" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/45/PDB_1oy3_EBI.jpg/180px-PDB_1oy3_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/45/PDB_1oy3_EBI.jpg/270px-PDB_1oy3_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/45/PDB_1oy3_EBI.jpg/360px-PDB_1oy3_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1oy3</b>: CRYSTAL STRUCTURE OF AN IKBBETA/NF-KB P65 HOMODIMER COMPLEX</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1ram_EBI.jpg" class="mw-file-description" title="1ram: A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER"><img alt="1ram: A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/62/PDB_1ram_EBI.jpg/180px-PDB_1ram_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/62/PDB_1ram_EBI.jpg/270px-PDB_1ram_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/62/PDB_1ram_EBI.jpg/360px-PDB_1ram_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1ram</b>: A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1vkx_EBI.jpg" class="mw-file-description" title="1vkx: CRYSTAL STRUCTURE OF THE NFKB P50/P65 HETERODIMER COMPLEXED TO THE IMMUNOGLOBULIN KB DNA"><img alt="1vkx: CRYSTAL STRUCTURE OF THE NFKB P50/P65 HETERODIMER COMPLEXED TO THE IMMUNOGLOBULIN KB DNA" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a8/PDB_1vkx_EBI.jpg/180px-PDB_1vkx_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a8/PDB_1vkx_EBI.jpg/270px-PDB_1vkx_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a8/PDB_1vkx_EBI.jpg/360px-PDB_1vkx_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1vkx</b>: CRYSTAL STRUCTURE OF THE NFKB P50/P65 HETERODIMER COMPLEXED TO THE IMMUNOGLOBULIN KB DNA</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2i9t_EBI.jpg" class="mw-file-description" title="2i9t: Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter"><img alt="2i9t: Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/53/PDB_2i9t_EBI.jpg/180px-PDB_2i9t_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/53/PDB_2i9t_EBI.jpg/270px-PDB_2i9t_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/53/PDB_2i9t_EBI.jpg/360px-PDB_2i9t_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2i9t</b>: Structure of NF-kB p65-p50 heterodimer bound to PRDII element of B-interferon promoter</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2ram_EBI.jpg" class="mw-file-description" title="2ram: A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER"><img alt="2ram: A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1e/PDB_2ram_EBI.jpg/180px-PDB_2ram_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1e/PDB_2ram_EBI.jpg/270px-PDB_2ram_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1e/PDB_2ram_EBI.jpg/360px-PDB_2ram_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2ram</b>: A NOVEL DNA RECOGNITION MODE BY NF-KB P65 HOMODIMER</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Transcription_factors_and_intracellular_receptors" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3;"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Transcription_factors_and_intracellular_receptors" title="Template:Transcription factors and intracellular receptors"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Transcription_factors_and_intracellular_receptors" title="Template talk:Transcription factors and intracellular receptors"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Transcription_factors_and_intracellular_receptors" title="Special:EditPage/Template:Transcription factors and intracellular receptors"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Transcription_factors_and_intracellular_receptors" style="font-size:114%;margin:0 4em"><a href="/wiki/Transcription_factor" title="Transcription factor">Transcription factors</a> and <a href="/wiki/Intracellular_receptor" title="Intracellular receptor">intracellular receptors</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(1)_Basic_domains" style="font-size:114%;margin:0 4em"><i>(1) Basic domains</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.1) Basic</i> <a href="/wiki/Leucine_zipper" title="Leucine zipper">leucine zipper</a> (<a href="/wiki/BZIP_domain" title="BZIP domain">bZIP</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activating_transcription_factor" title="Activating transcription factor">Activating transcription factor</a> <ul><li><a href="/wiki/Apoptosis-antagonizing_transcription_factor" class="mw-redirect" title="Apoptosis-antagonizing transcription factor">AATF</a></li> <li><a href="/wiki/ATF1" title="ATF1">1</a></li> <li><a href="/wiki/Activating_transcription_factor_2" title="Activating transcription factor 2">2</a></li> <li><a href="/wiki/ATF3" title="ATF3">3</a></li> <li><a href="/wiki/ATF4" title="ATF4">4</a></li> <li><a href="/wiki/ATF5" title="ATF5">5</a></li> <li><a href="/wiki/ATF6" title="ATF6">6</a></li> <li><a href="/wiki/ATF7" title="ATF7">7</a></li></ul></li> <li><a href="/wiki/AP-1_transcription_factor" title="AP-1 transcription factor">AP-1</a> <ul><li><a href="/wiki/C-Fos" class="mw-redirect" title="C-Fos">c-Fos</a></li> <li><a href="/wiki/FOSB" title="FOSB">FOSB</a></li> <li><a href="/wiki/FOSL1" title="FOSL1">FOSL1</a></li> <li><a href="/wiki/FOSL2" title="FOSL2">FOSL2</a></li> <li><a href="/wiki/Jun_dimerization_protein" title="Jun dimerization protein">JDP2</a></li> <li><a href="/wiki/C-jun" class="mw-redirect" title="C-jun">c-Jun</a></li> <li><a href="/wiki/JUNB" title="JUNB">JUNB</a></li> <li><a href="/wiki/JunD" title="JunD">JunD</a></li></ul></li> <li><i>BACH</i> <ul><li><a href="/wiki/BACH1" title="BACH1">1</a></li> <li><a href="/wiki/BACH2" title="BACH2">2</a></li></ul></li> <li><a href="/wiki/BATF_(gene)" title="BATF (gene)">BATF</a></li> <li><a href="/wiki/BLZF1" title="BLZF1">BLZF1</a></li> <li><a href="/wiki/Ccaat-enhancer-binding_proteins" class="mw-redirect" title="Ccaat-enhancer-binding proteins">C/EBP</a> <ul><li><a href="/wiki/CEBPA" title="CEBPA">α</a></li> <li><a href="/wiki/CEBPB" title="CEBPB">β</a></li> <li><a href="/wiki/CEBPG" title="CEBPG">γ</a></li> <li><a href="/wiki/CEBPD" title="CEBPD">δ</a></li> <li><a href="/wiki/CEBPE" title="CEBPE">ε</a></li> <li><a href="/wiki/CCAAT/enhancer_binding_protein_zeta" title="CCAAT/enhancer binding protein zeta">ζ</a></li></ul></li> <li><a href="/wiki/CREB" title="CREB">CREB</a> <ul><li><a href="/wiki/CREB1" title="CREB1">1</a></li> <li><a href="/wiki/CREB3" title="CREB3">3</a></li> <li><a href="/wiki/CREBL1" title="CREBL1">L1</a></li></ul></li> <li><a href="/wiki/CAMP_responsive_element_modulator" title="CAMP responsive element modulator">CREM</a></li> <li><a href="/wiki/DBP_(gene)" title="DBP (gene)">DBP</a></li> <li><a href="/wiki/DNA_damage-inducible_transcript_3" title="DNA damage-inducible transcript 3">DDIT3</a></li> <li><a href="/wiki/GABPA" title="GABPA">GABPA</a></li> <li><a href="/wiki/Gcn4" title="Gcn4">GCN4</a></li> <li><a href="/wiki/HLF_(gene)" title="HLF (gene)">HLF</a></li> <li><a href="/wiki/MAF_(gene)" title="MAF (gene)">MAF</a> <ul><li><a href="/wiki/MAFB_(gene)" title="MAFB (gene)">B</a></li> <li><a href="/wiki/MAFF_(gene)" title="MAFF (gene)">F</a></li> <li><a href="/wiki/MAFG" title="MAFG">G</a></li> <li><a href="/wiki/MAFK" title="MAFK">K</a></li></ul></li> <li><i>NFE</i> <ul><li><a href="/wiki/NFE2" title="NFE2">2</a></li> <li><a href="/wiki/NFE2L1" title="NFE2L1">L1</a></li> <li><a href="/wiki/NFE2L2" title="NFE2L2">L2</a></li> <li><a href="/wiki/NFE2L3" title="NFE2L3">L3</a></li></ul></li> <li><a href="/wiki/NFIL3" title="NFIL3">NFIL3</a></li> <li><a href="/wiki/NRL_(gene)" title="NRL (gene)">NRL</a></li> <li><i>NRF</i> <ul><li><a href="/wiki/NRF1" title="NRF1">1</a></li> <li><a href="/wiki/NFE2L2" title="NFE2L2">2</a></li> <li><a href="/wiki/NFE2L3" title="NFE2L3">3</a></li></ul></li> <li><a href="/wiki/XBP1" title="XBP1">XBP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.2) Basic helix-loop-helix</i> (<a href="/wiki/Basic_helix-loop-helix" class="mw-redirect" title="Basic helix-loop-helix">bHLH</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group A</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Achaete-scute_complex" title="Achaete-scute complex">AS-C</a> <ul><li><a href="/wiki/ASCL1" title="ASCL1">ASCL1</a></li> <li><a href="/wiki/ASCL2" title="ASCL2">ASCL2</a></li></ul></li> <li><a href="/wiki/ATOH1" title="ATOH1">ATOH1</a></li> <li><i>HAND</i> <ul><li><a href="/wiki/HAND1" title="HAND1">1</a></li> <li><a href="/wiki/HAND2" title="HAND2">2</a></li></ul></li> <li><a href="/wiki/MESP2" title="MESP2">MESP2</a></li> <li><a href="/wiki/Myogenic_regulatory_factors" title="Myogenic regulatory factors">Myogenic regulatory factors</a> <ul><li><a href="/wiki/MyoD" title="MyoD">MyoD</a></li> <li><a href="/wiki/Myogenin" title="Myogenin">Myogenin</a></li> <li><a href="/wiki/MYF5" title="MYF5">MYF5</a></li> <li><a href="/wiki/MYF6" title="MYF6">MYF6</a></li></ul></li> <li><a href="/wiki/NeuroD" title="NeuroD">NeuroD</a> <ul><li><a href="/wiki/NEUROD1" title="NEUROD1">1</a></li> <li><a href="/wiki/NEUROD2" title="NEUROD2">2</a></li></ul></li> <li><a href="/wiki/Neurogenins" title="Neurogenins">Neurogenins</a> <ul><li><a href="/wiki/NEUROG1" class="mw-redirect" title="NEUROG1">1</a></li> <li><a href="/wiki/NEUROG2" class="mw-redirect" title="NEUROG2">2</a></li> <li><a href="/wiki/NEUROG3" class="mw-redirect" title="NEUROG3">3</a></li></ul></li> <li><i>OLIG</i> <ul><li><a href="/wiki/OLIG1" title="OLIG1">1</a></li> <li><a href="/wiki/OLIG2" title="OLIG2">2</a></li></ul></li> <li><i>Paraxis</i> <ul><li><a href="/wiki/TCF15" title="TCF15">TCF15</a></li> <li><a href="/wiki/Scleraxis" title="Scleraxis">Scleraxis</a></li></ul></li> <li><i>SLC</i> <ul><li><a href="/wiki/LYL1" title="LYL1">LYL1</a></li> <li><i>TAL</i> <ul><li><a href="/wiki/TAL1" title="TAL1">1</a></li> <li><a href="/wiki/TAL2" title="TAL2">2</a></li></ul></li></ul></li> <li><a href="/wiki/Twist_transcription_factor" class="mw-redirect" title="Twist transcription factor">Twist</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group B</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FIGLA" title="FIGLA">FIGLA</a></li> <li><a href="/wiki/Myc" title="Myc">Myc</a> <ul><li><a href="/wiki/MYC" title="MYC">c-Myc</a></li> <li><a href="/wiki/MYCL" title="MYCL">l-Myc</a></li> <li><a href="/wiki/N-Myc" title="N-Myc">n-Myc</a></li></ul></li> <li><a href="/wiki/MXD4" title="MXD4">MXD4</a></li> <li><a href="/wiki/TCF4" title="TCF4">TCF4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group C<br />bHLH-<a href="/wiki/PAS_domain" title="PAS domain">PAS</a></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aryl_hydrocarbon_receptor" title="Aryl hydrocarbon receptor">AhR</a></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor_repressor" title="Aryl hydrocarbon receptor repressor">AHRR</a></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor_nuclear_translocator" title="Aryl hydrocarbon receptor nuclear translocator">ARNT</a> <ul><li><a href="/wiki/ARNTL" class="mw-redirect" title="ARNTL">ARNTL</a></li> <li><a href="/wiki/ARNTL2" title="ARNTL2">ARNTL2</a></li></ul></li> <li><a href="/wiki/CLOCK" title="CLOCK">CLOCK</a></li> <li><a href="/wiki/Hypoxia-inducible_factor" title="Hypoxia-inducible factor">HIF</a> <ul><li><a href="/wiki/HIF1A" title="HIF1A">1A</a></li> <li><a href="/wiki/EPAS1" title="EPAS1">EPAS1</a></li> <li><a href="/wiki/HIF3A" title="HIF3A">3A</a></li></ul></li> <li>NPAS <ul><li><a href="/wiki/NPAS1" title="NPAS1">1</a></li> <li><a href="/wiki/NPAS2" title="NPAS2">2</a></li> <li><a href="/wiki/NPAS3" title="NPAS3">3</a></li></ul></li> <li><i>PER</i> <ul><li><a href="/wiki/PER1" class="mw-redirect" title="PER1">1</a></li> <li><a href="/wiki/PER2" title="PER2">2</a></li> <li><a href="/wiki/PER3" title="PER3">3</a></li> <li><a href="/wiki/Period_(gene)" title="Period (gene)">Period</a></li></ul></li> <li><i>SIM</i> <ul><li><a href="/wiki/SIM1" title="SIM1">1</a></li> <li><a href="/wiki/SIM2" title="SIM2">2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group D</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>BHLH</i> <ul><li><a href="/wiki/BHLHB2" title="BHLHB2">2</a></li> <li><a href="/wiki/BHLHB3" class="mw-redirect" title="BHLHB3">3</a></li> <li><a href="/wiki/BHLHA9" title="BHLHA9">9</a></li></ul></li> <li><a href="/wiki/Pho4" title="Pho4">Pho4</a></li> <li><i>ID</i> <ul><li><a href="/wiki/ID1" title="ID1">1</a></li> <li><a href="/wiki/ID2" title="ID2">2</a></li> <li><a href="/wiki/ID3_(gene)" title="ID3 (gene)">3</a></li> <li><a href="/wiki/ID4" title="ID4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group E</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>HES</i> <ul><li><a href="/wiki/HES1" title="HES1">1</a></li> <li><a href="/wiki/Hes_family_bhlh_transcription_factor_2" title="Hes family bhlh transcription factor 2">2</a></li> <li><a href="/wiki/HES3" title="HES3">3</a></li> <li><a href="/wiki/HES4" title="HES4">4</a></li> <li><a href="/wiki/HES5" title="HES5">5</a></li> <li><a href="/wiki/HES6" title="HES6">6</a></li> <li><a href="/wiki/HES7_gene" title="HES7 gene">7</a></li></ul></li> <li><i>HEY</i> <ul><li><a href="/wiki/HEY1" title="HEY1">1</a></li> <li><a href="/wiki/HEY2" title="HEY2">2</a></li> <li><a href="/wiki/HEYL" title="HEYL">L</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group F<br />bHLH-COE</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/EBF1" title="EBF1">EBF1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.3)</i> <a href="/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors" title="Basic helix-loop-helix leucine zipper transcription factors">bHLH-ZIP</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TFAP4" title="TFAP4">AP-4</a></li> <li><a href="/wiki/MAX_(gene)" title="MAX (gene)">MAX</a> <ul><li><a href="/wiki/MXD1" title="MXD1">MXD1</a></li> <li><a href="/wiki/MXD3" title="MXD3">MXD3</a></li></ul></li> <li><a href="/wiki/Microphthalmia-associated_transcription_factor" title="Microphthalmia-associated transcription factor">MITF</a></li> <li><a href="/wiki/MNT_(gene)" title="MNT (gene)">MNT</a></li> <li><a href="/wiki/MLX_(gene)" title="MLX (gene)">MLX</a></li> <li><a href="/wiki/Carbohydrate-responsive_element-binding_protein" title="Carbohydrate-responsive element-binding protein">MLXIPL</a></li> <li><a href="/wiki/MXI1" title="MXI1">MXI1</a></li> <li><a href="/wiki/Myc" title="Myc">Myc</a></li> <li><a href="/wiki/Sterol_regulatory_element-binding_protein" title="Sterol regulatory element-binding protein">SREBP</a> <ul><li><a href="/wiki/SREBF1" class="mw-redirect" title="SREBF1">1</a></li> <li><a href="/wiki/SREBF2" class="mw-redirect" title="SREBF2">2</a></li></ul></li> <li><a href="/wiki/USF1" title="USF1">USF1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.4) NF-1</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nuclear_factor_I" title="Nuclear factor I">NFI</a> <ul><li><a href="/wiki/NFIA" title="NFIA">A</a></li> <li><a href="/wiki/NFIB_(gene)" title="NFIB (gene)">B</a></li> <li><a href="/wiki/NFIC_(gene)" title="NFIC (gene)">C</a></li> <li><a href="/wiki/NFIX" title="NFIX">X</a></li></ul></li> <li><a href="/wiki/SMAD_(protein)" title="SMAD (protein)">SMAD</a> <ul><li><a href="/wiki/R-SMAD" title="R-SMAD">R-SMAD</a> <ul><li><a href="/wiki/Mothers_against_decapentaplegic_homolog_1" title="Mothers against decapentaplegic homolog 1">1</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_2" title="Mothers against decapentaplegic homolog 2">2</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_3" title="Mothers against decapentaplegic homolog 3">3</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_5" title="Mothers against decapentaplegic homolog 5">5</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_9" title="Mothers against decapentaplegic homolog 9">9</a></li></ul></li> <li><a href="/wiki/I-SMAD" title="I-SMAD">I-SMAD</a> <ul><li><a href="/wiki/Mothers_against_decapentaplegic_homolog_6" title="Mothers against decapentaplegic homolog 6">6</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_7" title="Mothers against decapentaplegic homolog 7">7</a></li></ul></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_4" title="Mothers against decapentaplegic homolog 4">4</a>)</li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.5) RF-X</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>RFX</i> <ul><li><a href="/wiki/RFX1" title="RFX1">1</a></li> <li><a href="/wiki/RFX2" title="RFX2">2</a></li> <li><a href="/wiki/RFX3" title="RFX3">3</a></li> <li><a href="/wiki/RFX4" title="RFX4">4</a></li> <li><a href="/wiki/RFX5" title="RFX5">5</a></li> <li><a href="/wiki/RFX6" title="RFX6">6</a></li> <li><a href="/wiki/RFXANK" title="RFXANK">ANK</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.6) Basic helix-span-helix (bHSH)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activating_protein_2" title="Activating protein 2">AP-2</a> <ul><li><a href="/wiki/TFAP2A" title="TFAP2A">α</a></li> <li><a href="/wiki/TFAP2B" title="TFAP2B">β</a></li> <li><a href="/wiki/TFAP2C" title="TFAP2C">γ</a></li> <li><a href="/wiki/TFAP2D" title="TFAP2D">δ</a></li> <li><a href="/wiki/TFAP2E" title="TFAP2E">ε</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(2)_Zinc_finger_DNA-binding_domains" style="font-size:114%;margin:0 4em"><i>(2)</i> <a href="/wiki/Zinc_finger" title="Zinc finger">Zinc finger</a> DNA-binding domains</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.1)</i> <a href="/wiki/Nuclear_receptor" title="Nuclear receptor">Nuclear receptor</a> <i>(Cys<sub>4</sub>)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 1</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Thyroid_hormone_receptor" title="Thyroid hormone receptor">Thyroid hormone</a> <ul><li><a href="/wiki/Thyroid_hormone_receptor_alpha" title="Thyroid hormone receptor alpha">α</a></li> <li><a href="/wiki/Thyroid_hormone_receptor_beta" title="Thyroid hormone receptor beta">β</a></li></ul></li> <li><a href="/wiki/Constitutive_androstane_receptor" title="Constitutive androstane receptor">CAR</a></li> <li><a href="/wiki/Farnesoid_X_receptor" title="Farnesoid X receptor">FXR</a></li> <li><a href="/wiki/Liver_X_receptor" title="Liver X receptor">LXR</a> <ul><li><a href="/wiki/Liver_X_receptor_alpha" title="Liver X receptor alpha">α</a></li> <li><a href="/wiki/Liver_X_receptor_beta" title="Liver X receptor beta">β</a></li></ul></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor" title="Peroxisome proliferator-activated receptor">PPAR</a> <ul><li><a href="/wiki/Peroxisome_proliferator-activated_receptor_alpha" title="Peroxisome proliferator-activated receptor alpha">α</a></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor_delta" title="Peroxisome proliferator-activated receptor delta">β/δ</a></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor_gamma" title="Peroxisome proliferator-activated receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Pregnane_X_receptor" title="Pregnane X receptor">PXR</a></li> <li><a href="/wiki/Retinoic_acid_receptor" title="Retinoic acid receptor">RAR</a> <ul><li><a href="/wiki/Retinoic_acid_receptor_alpha" title="Retinoic acid receptor alpha">α</a></li> <li><a href="/wiki/Retinoic_acid_receptor_beta" title="Retinoic acid receptor beta">β</a></li> <li><a href="/wiki/Retinoic_acid_receptor_gamma" title="Retinoic acid receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/RAR-related_orphan_receptor" title="RAR-related orphan receptor">ROR</a> <ul><li><a href="/wiki/RAR-related_orphan_receptor_alpha" title="RAR-related orphan receptor alpha">α</a></li> <li><a href="/wiki/RAR-related_orphan_receptor_beta" title="RAR-related orphan receptor beta">β</a></li> <li><a href="/wiki/RAR-related_orphan_receptor_gamma" title="RAR-related orphan receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Rev-ErbA" class="mw-redirect" title="Rev-ErbA">Rev-ErbA</a> <ul><li><a href="/wiki/Rev-ErbA_alpha" title="Rev-ErbA alpha">α</a></li> <li><a href="/wiki/Rev-ErbA_beta" title="Rev-ErbA beta">β</a></li></ul></li> <li><a href="/wiki/Calcitriol_receptor" class="mw-redirect" title="Calcitriol receptor">VDR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 2</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chicken_ovalbumin_upstream_promoter-transcription_factor" title="Chicken ovalbumin upstream promoter-transcription factor">COUP-TF</a> <ul><li>(<a href="/wiki/COUP-TFI" title="COUP-TFI">I</a></li> <li><a href="/wiki/COUP-TFII" title="COUP-TFII">II</a></li></ul></li> <li><a href="/wiki/V-erbA-related_gene" title="V-erbA-related gene">Ear-2</a></li> <li><a href="/wiki/Hepatocyte_nuclear_factor_4" title="Hepatocyte nuclear factor 4">HNF4</a> <ul><li><a href="/wiki/Hepatocyte_nuclear_factor_4_alpha" title="Hepatocyte nuclear factor 4 alpha">α</a></li> <li><a href="/wiki/Hepatocyte_nuclear_factor_4_gamma" title="Hepatocyte nuclear factor 4 gamma">γ</a></li></ul></li> <li><a href="/wiki/Photoreceptor_cell-specific_nuclear_receptor" title="Photoreceptor cell-specific nuclear receptor">PNR</a></li> <li><a href="/wiki/Retinoid_X_receptor" title="Retinoid X receptor">RXR</a> <ul><li><a href="/wiki/Retinoid_X_receptor_alpha" title="Retinoid X receptor alpha">α</a></li> <li><a href="/wiki/Retinoid_X_receptor_beta" title="Retinoid X receptor beta">β</a></li> <li><a href="/wiki/Retinoid_X_receptor_gamma" title="Retinoid X receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Testicular_receptor" title="Testicular receptor">Testicular receptor</a> <ul><li><a href="/wiki/Testicular_receptor_2" title="Testicular receptor 2">2</a></li> <li><a href="/wiki/Testicular_receptor_4" title="Testicular receptor 4">4</a></li></ul></li> <li><a href="/wiki/TLX" title="TLX">TLX</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 3</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Steroid_hormone_receptor" title="Steroid hormone receptor">Steroid hormone</a> <ul><li><a href="/wiki/Androgen_receptor" title="Androgen receptor">Androgen</a></li> <li><a href="/wiki/Estrogen_receptor" title="Estrogen receptor">Estrogen</a> <ul><li><a href="/wiki/Estrogen_receptor_alpha" title="Estrogen receptor alpha">α</a></li> <li><a href="/wiki/Estrogen_receptor_beta" title="Estrogen receptor beta">β</a></li></ul></li> <li><a href="/wiki/Glucocorticoid_receptor" title="Glucocorticoid receptor">Glucocorticoid</a></li> <li><a href="/wiki/Mineralocorticoid_receptor" title="Mineralocorticoid receptor">Mineralocorticoid</a></li> <li><a href="/wiki/Progesterone_receptor" title="Progesterone receptor">Progesterone</a></li></ul></li> <li><a href="/wiki/Estrogen-related_receptor" title="Estrogen-related receptor">Estrogen related</a> <ul><li><a href="/wiki/Estrogen-related_receptor_alpha" title="Estrogen-related receptor alpha">α</a></li> <li><a href="/wiki/Estrogen-related_receptor_beta" title="Estrogen-related receptor beta">β</a></li> <li><a href="/wiki/Estrogen-related_receptor_gamma" title="Estrogen-related receptor gamma">γ</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 4</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nur_(biology)" class="mw-redirect" title="Nur (biology)">NUR</a> <ul><li><a href="/wiki/Nuclear_receptor_4A1" title="Nuclear receptor 4A1">NGFIB</a></li> <li><a href="/wiki/Nuclear_receptor_4A3" title="Nuclear receptor 4A3">NOR1</a></li> <li><a href="/wiki/Nuclear_receptor_4A2" title="Nuclear receptor 4A2">NURR1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 5</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Liver_receptor_homolog-1" title="Liver receptor homolog-1">LRH-1</a></li> <li><a href="/wiki/Steroidogenic_factor_1" title="Steroidogenic factor 1">SF1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 6</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Germ_cell_nuclear_factor" title="Germ cell nuclear factor">GCNF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 0</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/DAX1" title="DAX1">DAX1</a></li> <li><a href="/wiki/Small_heterodimer_partner" title="Small heterodimer partner">SHP</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.2) Other Cys<sub>4</sub></i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GATA_transcription_factor" title="GATA transcription factor">GATA</a> <ul><li><a href="/wiki/GATA1" title="GATA1">1</a></li> <li><a href="/wiki/GATA2" title="GATA2">2</a></li> <li><a href="/wiki/GATA3" title="GATA3">3</a></li> <li><a href="/wiki/GATA4" title="GATA4">4</a></li> <li><a href="/wiki/GATA5" title="GATA5">5</a></li> <li><a href="/wiki/GATA6" title="GATA6">6</a></li></ul></li> <li><i>MTA</i> <ul><li><a href="/wiki/MTA1" title="MTA1">1</a></li> <li><a href="/wiki/MTA2" title="MTA2">2</a></li> <li><a href="/wiki/MTA3" title="MTA3">3</a></li></ul></li> <li><a href="/wiki/Tricho-rhino-phalangeal_syndrome_Type_1" title="Tricho-rhino-phalangeal syndrome Type 1">TRPS1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.3) Cys<sub>2</sub>His<sub>2</sub></i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/General_transcription_factor" title="General transcription factor">General transcription factors</a> <ul><li><a href="/wiki/Transcription_factor_II_A" title="Transcription factor II A">TFIIA</a></li> <li><a href="/wiki/Transcription_factor_II_B" title="Transcription factor II B">TFIIB</a></li> <li><a href="/wiki/Transcription_factor_II_D" title="Transcription factor II D">TFIID</a></li> <li><a href="/wiki/Transcription_factor_II_E" title="Transcription factor II E">TFIIE</a> <ul><li><a href="/wiki/GTF2E1" title="GTF2E1">1</a></li> <li><a href="/wiki/GTF2E2" title="GTF2E2">2</a></li></ul></li> <li><a href="/wiki/Transcription_factor_II_F" title="Transcription factor II F">TFIIF</a></li> <li><a href="/wiki/GTF2F1" title="GTF2F1">1</a></li> <li><a href="/wiki/GTF2F2" title="GTF2F2">2</a> <ul><li><a href="/wiki/Transcription_factor_II_H" title="Transcription factor II H">TFIIH</a></li> <li><a href="/wiki/GTF2H1" title="GTF2H1">1</a></li> <li><a href="/wiki/GTF2H2" title="GTF2H2">2</a></li> <li><a href="/wiki/GTF2H4" title="GTF2H4">4</a></li> <li><a href="/wiki/GTF2I" title="GTF2I">2I</a></li> <li><a href="/wiki/GTF3A" title="GTF3A">3A</a></li> <li><a href="/wiki/GTF3C1" title="GTF3C1">3C1</a></li> <li><a href="/wiki/GTF3C2" title="GTF3C2">3C2</a></li></ul></li></ul></li></ul> <ul><li><a href="/wiki/ATBF1" title="ATBF1">ATBF1</a></li> <li><i><a href="/wiki/B-cell_CLL/lymphoma" title="B-cell CLL/lymphoma">BCL</a></i> <ul><li><a href="/wiki/BCL6" title="BCL6">6</a></li> <li><a href="/wiki/BCL11A" title="BCL11A">11A</a></li> <li><a href="/wiki/BCL11B" title="BCL11B">11B</a></li></ul></li> <li><a href="/wiki/CTCF" title="CTCF">CTCF</a></li> <li><a href="/wiki/E4F1" title="E4F1">E4F1</a></li> <li><a href="/wiki/Early_growth_response_proteins" title="Early growth response proteins">EGR</a> <ul><li><a href="/wiki/EGR1" title="EGR1">1</a></li> <li><a href="/wiki/EGR2" title="EGR2">2</a></li> <li><a href="/wiki/EGR3" title="EGR3">3</a></li> <li><a href="/wiki/EGR4" title="EGR4">4</a></li></ul></li> <li><a href="/wiki/ERV3" title="ERV3">ERV3</a></li> <li><a href="/wiki/GFI1" title="GFI1">GFI1</a></li> <li><i>GLI family</i> <ul><li><a href="/wiki/GLI1" title="GLI1">1</a></li> <li><a href="/wiki/GLI2" title="GLI2">2</a></li> <li><a href="/wiki/GLI3" title="GLI3">3</a></li> <li><a href="/wiki/RE1-silencing_transcription_factor" title="RE1-silencing transcription factor">REST</a></li> <li><a href="/wiki/GLIS1" title="GLIS1">S1</a></li> <li><a href="/wiki/GLIS2" title="GLIS2">S2</a></li> <li><a href="/wiki/YY1" title="YY1">YY1</a></li></ul></li> <li><i>HIC</i> <ul><li><a href="/wiki/HIC1" title="HIC1">1</a></li> <li><a href="/wiki/HIC2" title="HIC2">2</a></li></ul></li> <li><i>HIVEP</i> <ul><li><a href="/wiki/HIVEP1" title="HIVEP1">1</a></li> <li><a href="/wiki/HIVEP2" title="HIVEP2">2</a></li> <li><a href="/wiki/HIVEP3" title="HIVEP3">3</a></li></ul></li> <li><i>IKZF</i> <ul><li><a href="/wiki/IKZF1" title="IKZF1">1</a></li> <li><a href="/wiki/IKZF2" title="IKZF2">2</a></li> <li><a href="/wiki/IKZF3" title="IKZF3">3</a></li></ul></li> <li><i>ILF</i> <ul><li><a href="/wiki/ILF2" title="ILF2">2</a></li> <li><a href="/wiki/ILF3" title="ILF3">3</a></li></ul></li> <li><a href="/wiki/Kruppel-like_factors" title="Kruppel-like factors">Sp/KLF family</a> <ul><li><i>KLF</i> <ul><li><a href="/wiki/KLF1" title="KLF1">1</a></li> <li><a href="/wiki/KLF2" title="KLF2">2</a></li> <li><a href="/wiki/KLF3" title="KLF3">3</a></li> <li><a href="/wiki/KLF4" title="KLF4">4</a></li> <li><a href="/wiki/KLF5" title="KLF5">5</a></li> <li><a href="/wiki/KLF6" title="KLF6">6</a></li> <li><a href="/wiki/KLF7" title="KLF7">7</a></li> <li><a href="/wiki/KLF8" title="KLF8">8</a></li> <li><a href="/wiki/KLF9" title="KLF9">9</a></li> <li><a href="/wiki/KLF10" title="KLF10">10</a></li> <li><a href="/wiki/KLF11" title="KLF11">11</a></li> <li><a href="/wiki/KLF12" title="KLF12">12</a></li> <li><a href="/wiki/KLF13" title="KLF13">13</a></li> <li><a href="/wiki/KLF14" title="KLF14">14</a></li> <li><a href="/wiki/KLF15" title="KLF15">15</a></li> <li><a href="/wiki/KLF17" title="KLF17">17</a></li></ul></li> <li><i>SP</i> <ul><li><a href="/wiki/Sp1_transcription_factor" class="mw-redirect" title="Sp1 transcription factor">1</a></li> <li><a href="/wiki/SP2_(gene)" class="mw-redirect" title="SP2 (gene)">2</a></li> <li><a href="/wiki/SP4_(gene)" class="mw-redirect" title="SP4 (gene)">4</a></li> <li><a href="/wiki/Sp7_transcription_factor" title="Sp7 transcription factor">7</a></li> <li><a href="/wiki/Sp8_transcription_factor" title="Sp8 transcription factor">8</a></li></ul></li></ul></li> <li><a href="/wiki/MTF1" title="MTF1">MTF1</a></li> <li><a href="/wiki/MYT1" title="MYT1">MYT1</a></li> <li><a href="/wiki/OSR1" title="OSR1">OSR1</a></li> <li><a href="/wiki/PRDM9" title="PRDM9">PRDM9</a></li> <li><i>SALL</i> <ul><li><a href="/wiki/SALL1" title="SALL1">1</a></li> <li><a href="/wiki/SALL2" title="SALL2">2</a></li> <li><a href="/wiki/SALL3" title="SALL3">3</a></li> <li><a href="/wiki/SALL4" title="SALL4">4</a></li></ul></li> <li><a href="/wiki/TSHZ3" title="TSHZ3">TSHZ3</a></li> <li><a href="/wiki/WT1" class="mw-redirect" title="WT1">WT1</a></li> <li><a href="/wiki/Zbtb7" title="Zbtb7">Zbtb7</a> <ul><li><a href="/wiki/ZBTB7A" title="ZBTB7A">7A</a></li> <li><a href="/wiki/ZBTB7B" title="ZBTB7B">7B</a></li></ul></li> <li><i>ZBTB</i> <ul><li><a href="/wiki/ZBTB11" title="ZBTB11">11</a></li> <li><a href="/wiki/Zinc_finger_and_BTB_domain-containing_protein_16" title="Zinc finger and BTB domain-containing protein 16">16</a></li> <li><a href="/wiki/ZBTB17" title="ZBTB17">17</a></li> <li><a href="/wiki/ZBTB20" title="ZBTB20">20</a></li> <li><a href="/wiki/ZBTB21" title="ZBTB21">21</a></li> <li><a href="/wiki/ZBTB32" title="ZBTB32">32</a></li> <li><a href="/wiki/ZBTB33" title="ZBTB33">33</a></li> <li><a href="/wiki/ZBTB40" title="ZBTB40">40</a></li></ul></li> <li><i>zinc finger</i> <ul><li><a href="/wiki/ZNF3" title="ZNF3">3</a></li> <li><a href="/wiki/ZNF7" title="ZNF7">7</a></li> <li><a href="/wiki/CNBP" title="CNBP">9</a></li> <li><a href="/wiki/ZNF10" title="ZNF10">10</a></li> <li><a href="/wiki/ZNF19" title="ZNF19">19</a></li> <li><a href="/wiki/ZNF22" title="ZNF22">22</a></li> <li><a href="/wiki/ZNF24" title="ZNF24">24</a></li> <li><a href="/wiki/ZNF33B" title="ZNF33B">33B</a></li> <li><a href="/wiki/ZNF34" title="ZNF34">34</a></li> <li><a href="/wiki/ZNF35" title="ZNF35">35</a></li> <li><a href="/wiki/ZNF41" title="ZNF41">41</a></li> <li><a href="/wiki/ZNF43" title="ZNF43">43</a></li> <li><a href="/wiki/ZNF44" title="ZNF44">44</a></li> <li><a href="/wiki/BCL6" title="BCL6">51</a></li> <li><a href="/wiki/ZNF74" title="ZNF74">74</a></li> <li><a href="/wiki/ZNF143" title="ZNF143">143</a></li> <li><a href="/wiki/ZNF146" title="ZNF146">146</a></li> <li><a href="/wiki/ZNF148" title="ZNF148">148</a></li> <li><a href="/wiki/Zinc_finger_protein_165" title="Zinc finger protein 165">165</a></li> <li><a href="/wiki/ZNF202" title="ZNF202">202</a></li> <li><a href="/wiki/ZNF217" title="ZNF217">217</a></li> <li><a href="/wiki/ZNF219" title="ZNF219">219</a></li> <li><a href="/wiki/ZNF238" title="ZNF238">238</a></li> <li><a href="/wiki/ZNF239" title="ZNF239">239</a></li> <li><a href="/wiki/ZNF259" title="ZNF259">259</a></li> <li><a href="/wiki/ZNF267" title="ZNF267">267</a></li> <li><a href="/wiki/EGR1" title="EGR1">268</a></li> <li><a href="/wiki/ZNF281" title="ZNF281">281</a></li> <li><a href="/wiki/ZNF300" title="ZNF300">300</a></li> <li><a href="/wiki/ZNF318" title="ZNF318">318</a></li> <li><a href="/wiki/ZNF330" title="ZNF330">330</a></li> <li><a href="/wiki/ZNF346" title="ZNF346">346</a></li> <li><a href="/wiki/ZNF350" title="ZNF350">350</a></li> <li><a href="/wiki/ZNF365" title="ZNF365">365</a></li> <li><a href="/wiki/ZNF366" title="ZNF366">366</a></li> <li><a href="/wiki/ZNF384" title="ZNF384">384</a></li> <li><a href="/wiki/ZNF423" title="ZNF423">423</a></li> <li><a href="/wiki/ZNF451" title="ZNF451">451</a></li> <li><a href="/wiki/ZNF452" title="ZNF452">452</a></li> <li><a href="/wiki/ZNF471" title="ZNF471">471</a></li> <li><a href="/wiki/ZNF593" title="ZNF593">593</a></li> <li><a href="/wiki/ZNF638" title="ZNF638">638</a></li> <li><a href="/wiki/ZNF644" title="ZNF644">644</a></li> <li><a href="/wiki/ZNF649" title="ZNF649">649</a></li> <li><a href="/wiki/ZNF655" title="ZNF655">655</a></li> <li><a href="/wiki/ZNF804A" class="mw-redirect" title="ZNF804A">804A</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.4) Cys<sub>6</sub></i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIVEP1" title="HIVEP1">HIVEP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.5) Alternating composition</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Autoimmune_regulator" title="Autoimmune regulator">AIRE</a></li> <li><a href="/wiki/DIDO1" title="DIDO1">DIDO1</a></li> <li><a href="/wiki/GRLF1" title="GRLF1">GRLF1</a></li> <li><i>ING</i> <ul><li><a href="/wiki/ING1" title="ING1">1</a></li> <li><a href="/wiki/ING2" title="ING2">2</a></li> <li><a href="/wiki/ING4" title="ING4">4</a></li></ul></li> <li><i>JARID</i> <ul><li><a href="/wiki/KDM5A" title="KDM5A">1A</a></li> <li><a href="/wiki/KDM5B" class="mw-redirect" title="KDM5B">1B</a></li> <li><a href="/wiki/KDM5C" title="KDM5C">1C</a></li> <li><a href="/wiki/KDM5D" title="KDM5D">1D</a></li> <li><a href="/wiki/JARID2" title="JARID2">2</a></li></ul></li> <li><a href="/wiki/KDM3B" title="KDM3B">JMJD1B</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.6) WRKY</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/WRKY_protein_domain" title="WRKY protein domain">WRKY</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(3)_Helix-turn-helix_domains" style="font-size:114%;margin:0 4em"><i>(3)</i> <a href="/wiki/Helix-turn-helix" title="Helix-turn-helix">Helix-turn-helix</a> <i>domains</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.1)</i> <a href="/wiki/Homeodomain_fold" class="mw-redirect" title="Homeodomain fold">Homeodomain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i><a href="/wiki/Antennapedia" title="Antennapedia">Antennapedia</a></i></span><br /><span class="nobold"><i>ANTP class</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>protoHOX</i></span><br /><span class="nobold"><i>Hox-like</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ParaHox" title="ParaHox">ParaHox</a> <ul><li><a href="/wiki/Gsx_(gene_family)" title="Gsx (gene family)">Gsx</a> <ul><li><a href="/wiki/GSX1" title="GSX1">1</a></li> <li><a href="/wiki/GSX2" title="GSX2">2</a></li></ul></li> <li><a href="/wiki/Xlox" class="mw-redirect" title="Xlox">Xlox</a> <ul><li><a href="/wiki/PDX1" title="PDX1">PDX1</a></li></ul></li> <li><a href="/wiki/Cdx" title="Cdx">Cdx</a> <ul><li><a href="/wiki/CDX1" class="mw-redirect" title="CDX1">1</a></li> <li><a href="/wiki/CDX2" class="mw-redirect" title="CDX2">2</a></li> <li><a href="/wiki/CDX4_(gene)" class="mw-redirect" title="CDX4 (gene)">4</a></li></ul></li></ul></li> <li>extended Hox: <a href="/wiki/Evx1" title="Evx1">Evx1</a></li> <li><a href="/w/index.php?title=Evx2&action=edit&redlink=1" class="new" title="Evx2 (page does not exist)">Evx2</a></li> <li><a href="/wiki/MEOX1" title="MEOX1">MEOX1</a></li> <li><a href="/wiki/MEOX2" title="MEOX2">MEOX2</a></li> <li><a href="/wiki/Homeobox" title="Homeobox">Homeobox</a> <ul><li><a href="/wiki/Homeobox_A1" title="Homeobox A1">A1</a></li> <li><a href="/wiki/HOXA2" title="HOXA2">A2</a></li> <li><a href="/wiki/HOXA3" title="HOXA3">A3</a></li> <li><a href="/wiki/HOXA4" title="HOXA4">A4</a></li> <li><a href="/wiki/HOXA5" title="HOXA5">A5</a></li> <li><a href="/wiki/HOXA7" title="HOXA7">A7</a></li> <li><a href="/wiki/HOXA9" title="HOXA9">A9</a></li> <li><a href="/wiki/Homeobox_A10" title="Homeobox A10">A10</a></li> <li><a href="/wiki/HOXA11" title="HOXA11">A11</a></li> <li><a href="/wiki/HOXA13" title="HOXA13">A13</a></li> <li><a href="/wiki/HOXB1" title="HOXB1">B1</a></li> <li><a href="/wiki/HOXB2" title="HOXB2">B2</a></li> <li><a href="/wiki/HOXB3" title="HOXB3">B3</a></li> <li><a href="/wiki/HOXB4" title="HOXB4">B4</a></li> <li><a href="/wiki/HOXB5" title="HOXB5">B5</a></li> <li><a href="/wiki/HOXB6" title="HOXB6">B6</a></li> <li><a href="/wiki/HOXB7" title="HOXB7">B7</a></li> <li><a href="/wiki/HOXB8" title="HOXB8">B8</a></li> <li><a href="/wiki/HOXB9" title="HOXB9">B9</a></li> <li><a href="/wiki/HOXB13" title="HOXB13">B13</a></li> <li><a href="/wiki/HOXC4" title="HOXC4">C4</a></li> <li><a href="/wiki/HOXC5" title="HOXC5">C5</a></li> <li><a href="/wiki/HOXC6" title="HOXC6">C6</a></li> <li><a href="/wiki/HOXC8" title="HOXC8">C8</a></li> <li><a href="/wiki/HOXC9" title="HOXC9">C9</a></li> <li><a href="/wiki/HOXC10" title="HOXC10">C10</a></li> <li><a href="/wiki/HOXC11" title="HOXC11">C11</a></li> <li><a href="/wiki/HOXC12" title="HOXC12">C12</a></li> <li><a href="/wiki/HOXC13" title="HOXC13">C13</a></li> <li><a href="/wiki/HOXD1" title="HOXD1">D1</a></li> <li><a href="/wiki/HOXD3" title="HOXD3">D3</a></li> <li><a href="/wiki/HOXD4" title="HOXD4">D4</a></li> <li><a href="/wiki/HOXD8" title="HOXD8">D8</a></li> <li><a href="/wiki/HOXD9" title="HOXD9">D9</a></li> <li><a href="/wiki/HOXD10" title="HOXD10">D10</a></li> <li><a href="/wiki/HOXD11" title="HOXD11">D11</a></li> <li><a href="/wiki/HOXD12" title="HOXD12">D12</a></li> <li><a href="/wiki/HOXD13" title="HOXD13">D13</a></li></ul></li> <li><a href="/w/index.php?title=GBX1&action=edit&redlink=1" class="new" title="GBX1 (page does not exist)">GBX1</a></li> <li><a href="/wiki/GBX2" title="GBX2">GBX2</a></li> <li><a href="/wiki/MNX1" title="MNX1">MNX1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>metaHOX</i></span><br /><span class="nobold"><i>NK-like</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=BARHL1&action=edit&redlink=1" class="new" title="BARHL1 (page does not exist)">BARHL1</a></li> <li><a href="/wiki/BARHL2" title="BARHL2">BARHL2</a></li> <li><a href="/w/index.php?title=BARX1&action=edit&redlink=1" class="new" title="BARX1 (page does not exist)">BARX1</a></li> <li><a href="/w/index.php?title=BARX2&action=edit&redlink=1" class="new" title="BARX2 (page does not exist)">BARX2</a></li> <li><a href="/wiki/Brain-specific_homeobox" title="Brain-specific homeobox">BSX</a></li> <li><i>DBX</i> <ul><li><a href="/wiki/DBX1" title="DBX1">1</a></li> <li><a href="/wiki/DBX2" title="DBX2">2</a></li></ul></li> <li><a href="/wiki/DLX_gene_family" title="DLX gene family">DLX</a> <ul><li><a href="/wiki/DLX1" title="DLX1">1</a></li> <li><a href="/wiki/DLX2" title="DLX2">2</a></li> <li><a href="/wiki/DLX3_(gene)" class="mw-redirect" title="DLX3 (gene)">3</a></li> <li><a href="/wiki/DLX4" title="DLX4">4</a></li> <li><a href="/wiki/DLX5" title="DLX5">5</a></li> <li><a href="/wiki/DLX6" title="DLX6">6</a></li></ul></li> <li><i><a href="/wiki/EMX_homeogene" title="EMX homeogene">EMX</a></i> <ul><li><a href="/wiki/EMX1" title="EMX1">1</a></li> <li><a href="/wiki/EMX2" title="EMX2">2</a></li></ul></li> <li><i>EN</i> <ul><li><a href="/wiki/EN1_(gene)" title="EN1 (gene)">1</a></li> <li><a href="/wiki/EN2_(gene)" title="EN2 (gene)">2</a></li></ul></li> <li><a href="/wiki/HHEX" title="HHEX">HHEX</a></li> <li><a href="/wiki/HLX_(gene)" title="HLX (gene)">HLX</a></li> <li><a href="/wiki/LBX1" title="LBX1">LBX1</a></li> <li><a href="/wiki/LBX2" title="LBX2">LBX2</a></li> <li><i>MSX</i> <ul><li><a href="/wiki/MSX1" class="mw-redirect" title="MSX1">1</a></li> <li><a href="/wiki/Msh_homeobox_2" title="Msh homeobox 2">2</a></li></ul></li> <li><a href="/wiki/Homeobox_protein_NANOG" title="Homeobox protein NANOG">NANOG</a></li> <li><a href="/wiki/NKX-homeodomain_factor" title="NKX-homeodomain factor">NKX</a> <ul><li><a href="/wiki/NK2_homeobox_1" title="NK2 homeobox 1">2-1</a></li> <li><a href="/wiki/NKX2-2" title="NKX2-2">2-2</a></li> <li><a href="/wiki/NKX2-3" title="NKX2-3">2-3</a></li> <li><a href="/wiki/Homeobox_protein_Nkx-2.5" title="Homeobox protein Nkx-2.5">2-5</a></li> <li><a href="/wiki/NKX3-1" title="NKX3-1">3-1</a></li> <li><a href="/wiki/NKX3-2" title="NKX3-2">3-2</a></li> <li><a href="/w/index.php?title=HMX1&action=edit&redlink=1" class="new" title="HMX1 (page does not exist)">HMX1</a></li> <li><a href="/w/index.php?title=HMX2&action=edit&redlink=1" class="new" title="HMX2 (page does not exist)">HMX2</a></li> <li><a href="/w/index.php?title=HMX3&action=edit&redlink=1" class="new" title="HMX3 (page does not exist)">HMX3</a></li> <li><a href="/wiki/NKX6-1" title="NKX6-1">6-1</a></li> <li><a href="/wiki/NKX6-2" title="NKX6-2">6-2</a></li></ul></li> <li><a href="/wiki/NATO" title="NATO">NATO</a></li> <li><a href="/wiki/TLX1" title="TLX1">TLX1</a></li> <li><a href="/wiki/TLX2" title="TLX2">TLX2</a></li> <li><a href="/wiki/TLX3" title="TLX3">TLX3</a></li> <li><a href="/wiki/VAX1" title="VAX1">VAX1</a></li> <li><a href="/w/index.php?title=VAX2&action=edit&redlink=1" class="new" title="VAX2 (page does not exist)">VAX2</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">other</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aristaless_related_homeobox" title="Aristaless related homeobox">ARX</a></li> <li><a href="/wiki/CRX_(gene)" title="CRX (gene)">CRX</a></li> <li><a href="/wiki/CUTL1" title="CUTL1">CUTL1</a></li> <li><i>FHL</i> <ul><li><a href="/wiki/FHL1" title="FHL1">1</a></li> <li><a href="/wiki/FHL2" title="FHL2">2</a></li> <li><a href="/wiki/FHL3" title="FHL3">3</a></li></ul></li> <li><a href="/wiki/HESX1" title="HESX1">HESX1</a></li> <li><a href="/wiki/HOPX" title="HOPX">HOPX</a></li> <li><i>LMX</i> <ul><li><a href="/wiki/LMX1A" title="LMX1A">1A</a></li> <li><a href="/wiki/LMX1B" title="LMX1B">1B</a></li></ul></li> <li><a href="/wiki/NOBOX" title="NOBOX">NOBOX</a></li> <li>TALE <ul><li><a href="/wiki/Iroquois_homeobox_factor" title="Iroquois homeobox factor">IRX</a> <ul><li><a href="/wiki/IRX1" title="IRX1">1</a></li> <li><a href="/wiki/IRX2" title="IRX2">2</a></li> <li><a href="/wiki/IRX3" title="IRX3">3</a></li> <li><a href="/wiki/IRX4" title="IRX4">4</a></li> <li><a href="/wiki/IRX5" title="IRX5">5</a></li> <li><a href="/wiki/IRX6" title="IRX6">6</a></li> <li><a href="/wiki/MKX" title="MKX">MKX</a></li></ul></li> <li><i>MEIS</i> <ul><li><a href="/wiki/MEIS1" title="MEIS1">1</a></li> <li><a href="/wiki/MEIS2" title="MEIS2">2</a></li></ul></li> <li><i>PBX</i> <ul><li><a href="/wiki/PBX1" title="PBX1">1</a></li> <li><a href="/wiki/PBX2" title="PBX2">2</a></li> <li><a href="/wiki/PBX3" title="PBX3">3</a></li></ul></li> <li><i>PKNOX</i> <ul><li><a href="/wiki/PKNOX1" title="PKNOX1">1</a></li> <li><a href="/wiki/PKNOX2" title="PKNOX2">2</a></li></ul></li> <li><i>SIX</i> <ul><li><a href="/wiki/SIX1" class="mw-redirect" title="SIX1">1</a></li> <li><a href="/wiki/SIX2" title="SIX2">2</a></li> <li><a href="/wiki/SIX3" title="SIX3">3</a></li> <li><a href="/wiki/SIX4" title="SIX4">4</a></li> <li><a href="/wiki/SIX5" title="SIX5">5</a></li></ul></li></ul></li> <li><i>PHF</i> <ul><li><a href="/wiki/PHF1" title="PHF1">1</a></li> <li><a href="/wiki/PHF3" title="PHF3">3</a></li> <li><a href="/wiki/PHF6" title="PHF6">6</a></li> <li><a href="/wiki/PHF8" title="PHF8">8</a></li> <li><a href="/wiki/PHF10" title="PHF10">10</a></li> <li><a href="/wiki/PHF16" title="PHF16">16</a></li> <li><a href="/wiki/PHF17" class="mw-redirect" title="PHF17">17</a></li> <li><a href="/wiki/PHF20" title="PHF20">20</a></li> <li><a href="/wiki/PHF21A" title="PHF21A">21A</a></li></ul></li> <li><a href="/wiki/POU_domain" title="POU domain">POU domain</a> <ul><li><a href="/wiki/Pituitary-specific_positive_transcription_factor_1" title="Pituitary-specific positive transcription factor 1">PIT-1</a></li> <li><a href="/wiki/BRN-3" title="BRN-3">BRN-3</a>: <a href="/wiki/POU4F1" title="POU4F1">A</a></li> <li><a href="/wiki/POU4F2" title="POU4F2">B</a></li> <li><a href="/wiki/POU4F3" title="POU4F3">C</a></li> <li><a href="/wiki/Octamer_transcription_factor" title="Octamer transcription factor">Octamer transcription factor</a>: <a href="/wiki/POU2F1" title="POU2F1">1</a></li> <li><a href="/wiki/Oct-2" title="Oct-2">2</a></li> <li><a href="/wiki/Oct-4" title="Oct-4">3/4</a></li> <li><a href="/wiki/POU3F1" title="POU3F1">6</a></li> <li><a href="/wiki/POU3F2" title="POU3F2">7</a></li> <li><a href="/wiki/POU3F4" title="POU3F4">11</a></li></ul></li> <li><a href="/wiki/SATB2" title="SATB2">SATB2</a></li> <li><i>ZEB</i> <ul><li><a href="/wiki/ZEB1" title="ZEB1">1</a></li> <li><a href="/wiki/ZEB2" title="ZEB2">2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.2) Paired box</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pax_genes" title="Pax genes">PAX</a> <ul><li><a href="/wiki/PAX1" title="PAX1">1</a></li> <li><a href="/wiki/PAX2" title="PAX2">2</a></li> <li><a href="/wiki/PAX3" title="PAX3">3</a></li> <li><a href="/wiki/PAX4" title="PAX4">4</a></li> <li><a href="/wiki/PAX5" title="PAX5">5</a></li> <li><a href="/wiki/PAX6" title="PAX6">6</a></li> <li><a href="/wiki/PAX7" title="PAX7">7</a></li> <li><a href="/wiki/PAX8" title="PAX8">8</a></li> <li><a href="/wiki/PAX9" title="PAX9">9</a></li></ul></li> <li>PRRX <ul><li><a href="/wiki/PRRX1" title="PRRX1">1</a></li> <li><a href="/wiki/PRRX2" title="PRRX2">2</a></li></ul></li> <li><a href="/wiki/PROP1" title="PROP1">PROP1</a></li> <li><i>PHOX</i> <ul><li><a href="/wiki/PHOX2A" title="PHOX2A">2A</a></li> <li><a href="/wiki/PHOX2B" title="PHOX2B">2B</a></li></ul></li> <li><a href="/wiki/Retinal_homeobox_protein_Rx" title="Retinal homeobox protein Rx">RAX</a></li> <li><a href="/wiki/Short-stature_homeobox_gene" title="Short-stature homeobox gene">SHOX</a></li> <li><a href="/wiki/SHOX2" title="SHOX2">SHOX2</a></li> <li><a href="/wiki/VSX1" title="VSX1">VSX1</a></li> <li><a href="/wiki/VSX2" title="VSX2">VSX2</a></li> <li><a href="/wiki/Bicoid_(gene)" class="mw-redirect" title="Bicoid (gene)">Bicoid</a> <ul><li><a href="/wiki/Goosecoid_protein" class="mw-redirect" title="Goosecoid protein">GSC</a></li> <li><a href="/wiki/BICD2" title="BICD2">BICD2</a></li> <li><i>OTX</i> <ul><li><a href="/wiki/OTX1" title="OTX1">1</a></li> <li><a href="/wiki/Orthodenticle_homeobox_2" title="Orthodenticle homeobox 2">2</a></li></ul></li> <li><i>PITX</i> <ul><li><a href="/wiki/PITX1" title="PITX1">1</a></li> <li><a href="/wiki/PITX2" title="PITX2">2</a></li> <li><a href="/wiki/PITX3" title="PITX3">3</a></li></ul></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.3)</i> <a href="/wiki/FOX_proteins" title="FOX proteins">Fork head</a> / <a href="/wiki/Winged-helix_transcription_factors" title="Winged-helix transcription factors">winged helix</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/E2F" title="E2F">E2F</a> <ul><li><a href="/wiki/E2F1" title="E2F1">1</a></li> <li><a href="/wiki/E2F2" title="E2F2">2</a></li> <li><a href="/wiki/E2F3" title="E2F3">3</a></li> <li><a href="/wiki/E2F4" title="E2F4">4</a></li> <li><a href="/wiki/E2F5" title="E2F5">5</a></li></ul></li> <li><a href="/wiki/FOX_proteins" title="FOX proteins">FOX proteins</a> <ul><li><a href="/wiki/FOXA1" title="FOXA1">A1</a></li> <li><a href="/wiki/FOXA2" title="FOXA2">A2</a></li> <li><a href="/wiki/FOXA3" title="FOXA3">A3</a></li> <li><a href="/wiki/FOXB1" class="mw-redirect" title="FOXB1">B1</a></li> <li><a href="/w/index.php?title=FOXB2&action=edit&redlink=1" class="new" title="FOXB2 (page does not exist)">B2</a></li> <li><a href="/wiki/Forkhead_box_C1" title="Forkhead box C1">C1</a></li> <li><a href="/wiki/FOXC2" title="FOXC2">C2</a></li> <li><a href="/wiki/FOXD1" class="mw-redirect" title="FOXD1">D1</a></li> <li><a href="/w/index.php?title=FOXD2&action=edit&redlink=1" class="new" title="FOXD2 (page does not exist)">D2</a></li> <li><a href="/wiki/FOXD3" title="FOXD3">D3</a></li> <li><a href="/wiki/FOXD4" title="FOXD4">D4</a></li> <li><a href="/w/index.php?title=FOXD4L1&action=edit&redlink=1" class="new" title="FOXD4L1 (page does not exist)">D4L1</a></li> <li><a href="/w/index.php?title=FOXD4L3&action=edit&redlink=1" class="new" title="FOXD4L3 (page does not exist)">D4L3</a></li> <li><a href="/w/index.php?title=FOXD4L4&action=edit&redlink=1" class="new" title="FOXD4L4 (page does not exist)">D4L4</a></li> <li><a href="/w/index.php?title=FOXD4L5&action=edit&redlink=1" class="new" title="FOXD4L5 (page does not exist)">D4L5</a></li> <li><a href="/w/index.php?title=FOXD4L6&action=edit&redlink=1" class="new" title="FOXD4L6 (page does not exist)">D4L6</a></li> <li><a href="/wiki/FOXE1" title="FOXE1">E1</a></li> <li><a href="/wiki/FOXE3" title="FOXE3">E3</a></li> <li><a href="/wiki/FOXF1" title="FOXF1">F1</a></li> <li><a href="/wiki/FOXF2" title="FOXF2">F2</a></li> <li><a href="/wiki/FOXG1" title="FOXG1">G1</a></li> <li><a href="/wiki/FOXH1" title="FOXH1">H1</a></li> <li><a href="/wiki/FOXI1" title="FOXI1">I1</a></li> <li><a href="/w/index.php?title=FOXI2&action=edit&redlink=1" class="new" title="FOXI2 (page does not exist)">I2</a></li> <li><a href="/wiki/FOXI3" title="FOXI3">I3</a></li> <li><a href="/wiki/FOXJ1" title="FOXJ1">J1</a></li> <li><a href="/wiki/FOXJ2" title="FOXJ2">J2</a></li> <li><a href="/w/index.php?title=FOXJ3&action=edit&redlink=1" class="new" title="FOXJ3 (page does not exist)">J3</a></li> <li><a href="/wiki/FOXK1" title="FOXK1">K1</a></li> <li><a href="/wiki/FOXK2" title="FOXK2">K2</a></li> <li><a href="/w/index.php?title=FOXL1&action=edit&redlink=1" class="new" title="FOXL1 (page does not exist)">L1</a></li> <li><a href="/wiki/Forkhead_box_L2" class="mw-redirect" title="Forkhead box L2">L2</a></li> <li><a href="/wiki/FOXM1" title="FOXM1">M1</a></li> <li><a href="/wiki/FOXN1" title="FOXN1">N1</a></li> <li><a href="/w/index.php?title=FOXN2&action=edit&redlink=1" class="new" title="FOXN2 (page does not exist)">N2</a></li> <li><a href="/wiki/FOXN3" title="FOXN3">N3</a></li> <li><a href="/w/index.php?title=FOXN4&action=edit&redlink=1" class="new" title="FOXN4 (page does not exist)">N4</a></li> <li><a href="/wiki/FOXO1" class="mw-redirect" title="FOXO1">O1</a></li> <li><a href="/wiki/FOXO3" title="FOXO3">O3</a></li> <li><a href="/wiki/FOXO4" title="FOXO4">O4</a></li> <li><a href="/wiki/FOXO6" title="FOXO6">O6</a></li> <li><a href="/wiki/FOXP1" title="FOXP1">P1</a></li> <li><a href="/wiki/FOXP2" title="FOXP2">P2</a></li> <li><a href="/wiki/FOXP3" title="FOXP3">P3</a></li> <li><a href="/wiki/FOXP4" title="FOXP4">P4</a></li> <li><a href="/wiki/FOXQ1" title="FOXQ1">Q1</a></li> <li><a href="/w/index.php?title=FOXR1&action=edit&redlink=1" class="new" title="FOXR1 (page does not exist)">R1</a></li> <li><a href="/w/index.php?title=FOXR2&action=edit&redlink=1" class="new" title="FOXR2 (page does not exist)">R2</a></li> <li><a href="/wiki/FOXS1" title="FOXS1">S1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.4)</i> <a href="/wiki/Heat_shock_factor" title="Heat shock factor">Heat shock factors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Heat_shock_factor" title="Heat shock factor">HSF</a></i> <ul><li><a href="/wiki/HSF1" class="mw-redirect" title="HSF1">1</a></li> <li><a href="/wiki/HSF2" title="HSF2">2</a></li> <li><a href="/wiki/HSF4" title="HSF4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.5) Tryptophan clusters</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>ELF</i> <ul><li><a href="/wiki/ELF2" title="ELF2">2</a></li> <li><a href="/wiki/ELF4" title="ELF4">4</a></li> <li><a href="/wiki/ELF5" title="ELF5">5</a></li></ul></li> <li><a href="/wiki/EHF_(gene)" title="EHF (gene)">EGF</a></li> <li><i>ELK</i> <ul><li><a href="/wiki/ELK1" title="ELK1">1</a></li> <li><a href="/wiki/ELK3" title="ELK3">3</a></li> <li><a href="/wiki/ELK4" title="ELK4">4</a></li></ul></li> <li><a href="/wiki/ERF_(gene)" title="ERF (gene)">ERF</a></li> <li><a href="/wiki/ETS_transcription_factor_family" title="ETS transcription factor family">ETS</a> <ul><li><a href="/wiki/ETS1" title="ETS1">1</a></li> <li><a href="/wiki/ETS2" title="ETS2">2</a></li> <li><a href="/wiki/ERG_(gene)" title="ERG (gene)">ERG</a></li> <li><a href="/wiki/SPIB" title="SPIB">SPIB</a></li></ul></li> <li><i>ETV</i> <ul><li><a href="/wiki/ETV1" title="ETV1">1</a></li> <li><a href="/wiki/ETV4" title="ETV4">4</a></li> <li><a href="/wiki/ERM_transcription_factor" class="mw-redirect" title="ERM transcription factor">5</a></li> <li><a href="/wiki/ETV6" title="ETV6">6</a></li></ul></li> <li><a href="/wiki/FLI1" title="FLI1">FLI1</a></li> <li><a href="/wiki/Interferon_regulatory_factors" title="Interferon regulatory factors">Interferon regulatory factors</a> <ul><li><a href="/wiki/IRF1" title="IRF1">1</a></li> <li><a href="/wiki/IRF2" title="IRF2">2</a></li> <li><a href="/wiki/IRF3" title="IRF3">3</a></li> <li><a href="/wiki/IRF4" title="IRF4">4</a></li> <li><a href="/wiki/IRF5" title="IRF5">5</a></li> <li><a href="/wiki/IRF6" title="IRF6">6</a></li> <li><a href="/wiki/IRF7" title="IRF7">7</a></li> <li><a href="/wiki/IRF8" title="IRF8">8</a></li></ul></li> <li><a href="/wiki/MYB_(gene)" title="MYB (gene)">MYB</a></li> <li><a href="/wiki/MYBL2" title="MYBL2">MYBL2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.6) TEA domain</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>transcriptional enhancer factor</i> <ul><li><a href="/wiki/TEAD1" title="TEAD1">1</a></li> <li><a href="/wiki/TEAD2" title="TEAD2">2</a></li> <li><a href="/wiki/TEAD3" title="TEAD3">3</a></li> <li><a href="/wiki/TEAD4" title="TEAD4">4</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible uncollapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(4)_β-Scaffold_factors_with_minor_groove_contacts" style="font-size:114%;margin:0 4em">(4) <i>β-Scaffold factors with minor groove contacts</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.1)</i> <a href="/wiki/Rel_homology_domain" title="Rel homology domain">Rel homology region</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/NF-%CE%BAB" title="NF-κB">NF-κB</a> <ul><li><a href="/wiki/NFKB1" title="NFKB1">NFKB1</a></li> <li><a href="/wiki/NFKB2" title="NFKB2">NFKB2</a></li> <li><a href="/wiki/REL" title="REL">REL</a></li> <li><a class="mw-selflink selflink">RELA</a></li> <li><a href="/wiki/RELB" title="RELB">RELB</a></li></ul></li> <li><a href="/wiki/NFAT" title="NFAT">NFAT</a> <ul><li><a href="/wiki/NFATC1" title="NFATC1">C1</a></li> <li><a href="/wiki/NFATC2" title="NFATC2">C2</a></li> <li><a href="/wiki/NFATC3" title="NFATC3">C3</a></li> <li><a href="/wiki/NFATC4" title="NFATC4">C4</a></li> <li><a href="/wiki/NFAT5" title="NFAT5">5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.2)</i> <a href="/wiki/STAT_protein" title="STAT protein">STAT</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/STAT_protein" title="STAT protein">STAT</a> <ul><li><a href="/wiki/STAT1" title="STAT1">1</a></li> <li><a href="/wiki/STAT2" title="STAT2">2</a></li> <li><a href="/wiki/STAT3" title="STAT3">3</a></li> <li><a href="/wiki/STAT4" title="STAT4">4</a></li> <li><a href="/wiki/STAT5" title="STAT5">5</a></li> <li><a href="/wiki/STAT6" title="STAT6">6</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.3) p53-like</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/P53_p63_p73_family" title="P53 p63 p73 family">p53 p63 p73 family</a> <ul><li><a href="/wiki/P53" title="P53">p53</a></li> <li><a href="/wiki/TP63" title="TP63">TP63</a></li> <li><a href="/wiki/P73" title="P73">p73</a></li></ul></li> <li><a href="/wiki/T-box" title="T-box">TBX</a> <ul><li><a href="/wiki/TBX1" title="TBX1">1</a></li> <li><a href="/wiki/TBX2" title="TBX2">2</a></li> <li><a href="/wiki/TBX3" title="TBX3">3</a></li> <li><a href="/wiki/TBX5_(gene)" title="TBX5 (gene)">5</a></li> <li><a href="/wiki/TBX19" title="TBX19">19</a></li> <li><a href="/wiki/TBX21" title="TBX21">21</a></li> <li><a href="/wiki/TBX22" title="TBX22">22</a></li> <li><a href="/wiki/TBR1" title="TBR1">TBR1</a></li> <li><a href="/wiki/Eomesodermin" title="Eomesodermin">TBR2</a></li> <li><a href="/wiki/Brachyury" class="mw-redirect" title="Brachyury">TFT</a></li></ul></li> <li><a href="/wiki/Myelin_regulatory_factor" title="Myelin regulatory factor">MYRF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.4)</i> <a href="/wiki/MADS-box" title="MADS-box">MADS box</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mef2" title="Mef2">Mef2</a> <ul><li><a href="/wiki/Myocyte-specific_enhancer_factor_2A" title="Myocyte-specific enhancer factor 2A">A</a></li> <li><a href="/wiki/MEF2B" title="MEF2B">B</a></li> <li><a href="/wiki/MEF2C" title="MEF2C">C</a></li> <li><a href="/wiki/MEF2D" title="MEF2D">D</a></li></ul></li> <li><a href="/wiki/Serum_response_factor" title="Serum response factor">SRF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.6)</i> <a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TATA-binding proteins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TBP</a></li> <li><a href="/wiki/TBPL1" title="TBPL1">TBPL1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.7)</i> <a href="/wiki/High-mobility_group" title="High-mobility group">High-mobility group</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BBX_(gene)" title="BBX (gene)">BBX</a></li> <li><a href="/wiki/HMG-box" title="HMG-box">HMGB</a> <ul><li><a href="/wiki/HMGB1" title="HMGB1">1</a></li> <li><a href="/wiki/HMGB2" title="HMGB2">2</a></li> <li><a href="/wiki/HMGB3" title="HMGB3">3</a></li> <li><a href="/wiki/HMGB4" title="HMGB4">4</a></li></ul></li> <li><a href="/wiki/HMGN" title="HMGN">HMGN</a> <ul><li><a href="/wiki/HMGN1" title="HMGN1">1</a></li> <li><a href="/wiki/HMGN2" title="HMGN2">2</a></li> <li><a href="/wiki/HMGN3" title="HMGN3">3</a></li> <li><a href="/wiki/HMGN4" title="HMGN4">4</a></li></ul></li> <li><i>HNF</i> <ul><li><a href="/wiki/HNF1A" title="HNF1A">1A</a></li> <li><a href="/wiki/HNF1B" title="HNF1B">1B</a></li></ul></li> <li><a href="/wiki/SOX_gene_family" title="SOX gene family">SOX</a> <ul><li><a href="/wiki/SOX1" title="SOX1">1</a></li> <li><a href="/wiki/SOX2" title="SOX2">2</a></li> <li><a href="/wiki/SOX3" title="SOX3">3</a></li> <li><a href="/wiki/SOX4" title="SOX4">4</a></li> <li><a href="/wiki/SOX5" title="SOX5">5</a></li> <li><a href="/wiki/SOX6" title="SOX6">6</a></li> <li><a href="/wiki/SOX8" title="SOX8">8</a></li> <li><a href="/wiki/SOX9" title="SOX9">9</a></li> <li><a href="/wiki/SOX10" title="SOX10">10</a></li> <li><a href="/wiki/SOX11" title="SOX11">11</a></li> <li><a href="/wiki/SOX12" title="SOX12">12</a></li> <li><a href="/wiki/SOX13" title="SOX13">13</a></li> <li><a href="/wiki/SOX14" title="SOX14">14</a></li> <li><a href="/wiki/SOX15" title="SOX15">15</a></li> <li><a href="/wiki/SOX18" title="SOX18">18</a></li> <li><a href="/wiki/SOX21" title="SOX21">21</a></li></ul></li> <li><a href="/wiki/Testis_determining_factor" class="mw-redirect" title="Testis determining factor">SRY</a></li> <li><a href="/wiki/Structure_specific_recognition_protein_1" title="Structure specific recognition protein 1">SSRP1</a></li> <li><a href="/wiki/TCF/LEF_family" title="TCF/LEF family">TCF/LEF</a> <ul><li><i>TCF</i> <ul><li><a href="/wiki/TCF7" title="TCF7">1</a></li> <li><a href="/wiki/TCF3" title="TCF3">3</a></li> <li><a href="/wiki/TCF7L2" title="TCF7L2">4</a></li></ul></li> <li><a href="/wiki/Lymphoid_enhancer-binding_factor_1" title="Lymphoid enhancer-binding factor 1">LEF1</a></li></ul></li> <li><i>TOX</i> <ul><li><a href="/wiki/TOX" title="TOX">1</a></li> <li><a href="/wiki/TOX2" title="TOX2">2</a></li> <li><a href="/wiki/TOX3" title="TOX3">3</a></li> <li><a href="/wiki/TOX4" title="TOX4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.9) Grainyhead</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TFCP2" title="TFCP2">TFCP2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.10) Cold-shock domain</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CSDA_(gene)" title="CSDA (gene)">CSDA</a></li> <li><a href="/wiki/Y_box_binding_protein_1" title="Y box binding protein 1">YBX1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.11) Runt</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Core_binding_factor" title="Core binding factor">CBF</a> <ul><li><a href="/wiki/CBFA2T2" title="CBFA2T2">CBFA2T2</a></li> <li><a href="/wiki/CBFA2T3" title="CBFA2T3">CBFA2T3</a></li> <li><a href="/wiki/RUNX1" title="RUNX1">RUNX1</a></li> <li><a href="/wiki/RUNX2" title="RUNX2">RUNX2</a></li> <li><a href="/wiki/RUNX3" title="RUNX3">RUNX3</a></li> <li><a href="/wiki/RUNX1T1" title="RUNX1T1">RUNX1T1</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(0)_Other_transcription_factors" style="font-size:114%;margin:0 4em"><i> (0) Other transcription factors</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;background:transparent;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.2) HMGI(Y)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HMGA" title="HMGA">HMGA</a> <ul><li><a href="/wiki/HMGA1" title="HMGA1">1</a></li> <li><a href="/wiki/HMGA2" title="HMGA2">2</a></li></ul></li> <li><a href="/wiki/HBP1" title="HBP1">HBP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.3)</i> <a href="/wiki/Pocket_protein_family" title="Pocket protein family">Pocket domain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Retinoblastoma_protein" title="Retinoblastoma protein">Rb</a></li> <li><a href="/wiki/Retinoblastoma-like_protein_1" title="Retinoblastoma-like protein 1">RBL1</a></li> <li><a href="/wiki/Retinoblastoma-like_protein_2" title="Retinoblastoma-like protein 2">RBL2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.5)</i> <a href="/wiki/Apetala_2" title="Apetala 2">AP-2</a><i>/</i><a href="/wiki/Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a><i>-related factors</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Apetala_2" title="Apetala 2">Apetala 2</a></li> <li><a href="/wiki/Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a></li> <li><a href="/wiki/B3_domain" title="B3 domain">B3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.6) Miscellaneous</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>ARID</i> <ul><li><a href="/wiki/ARID1A" title="ARID1A">1A</a></li> <li><a href="/wiki/ARID1B" title="ARID1B">1B</a></li> <li><a href="/wiki/ARID2" title="ARID2">2</a></li> <li><a href="/wiki/ARID3A" title="ARID3A">3A</a></li> <li><a href="/wiki/ARID3B" title="ARID3B">3B</a></li> <li><a href="/wiki/ARID4A" title="ARID4A">4A</a></li></ul></li> <li><a href="/wiki/Catabolite_activator_protein" title="Catabolite activator protein">CAP</a></li> <li><i>IFI</i> <ul><li><a href="/wiki/IFI16" title="IFI16">16</a></li> <li><a href="/wiki/IFI35" title="IFI35">35</a></li></ul></li> <li><a href="/wiki/MLL_(gene)" class="mw-redirect" title="MLL (gene)">MLL</a> <ul><li><a href="/wiki/MLL2" class="mw-redirect" title="MLL2">2</a></li> <li><a href="/wiki/MLL3" class="mw-redirect" title="MLL3">3</a></li> <li><a href="/wiki/MLLT1" title="MLLT1">T1</a></li></ul></li> <li><a href="/wiki/MNDA" title="MNDA">MNDA</a></li> <li><i>NFY</i> <ul><li><a href="/wiki/NFYA" title="NFYA">A</a></li> <li><a href="/wiki/NFYB" title="NFYB">B</a></li> <li><a href="/wiki/NFYC" title="NFYC">C</a></li></ul></li> <li><a href="/wiki/Rho_factor" title="Rho factor">Rho</a>/<a href="/wiki/Sigma_factor" title="Sigma factor">Sigma</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div><i>see also <a href="/wiki/Template:Transcription_factor_and_coregulator_deficiencies" title="Template:Transcription factor and coregulator deficiencies">transcription factor/coregulator deficiencies</a></i></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=RELA&oldid=1235434179">https://en.wikipedia.org/w/index.php?title=RELA&oldid=1235434179</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" 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