Screening of Some Saudi Plants for Their Alleviating Effect on the Exaggerated Vasoconstriction in Metabolic Syndrome

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for Their Alleviating Effect on the Exaggerated Vasoconstriction in Metabolic Syndrome</title> <meta name="description" content="Screening of Some Saudi Plants for Their Alleviating Effect on the Exaggerated Vasoconstriction in Metabolic Syndrome"> <meta name="keywords" content="vascular dysfunction, exaggerated vasoconstriction, metabolic syndrome, Saudi plants"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a 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87481</div> </div> </div> </div> <div class="card publication-listing mt-3 mb-3"> <h5 class="card-header" style="font-size:.9rem">Screening of Some Saudi Plants for Their Alleviating Effect on the Exaggerated Vasoconstriction in Metabolic Syndrome</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Hossam%20M.%20Abdallah">Hossam M. Abdallah</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20M.%20El-Halawany"> Ali M. El-Halawany</a>, <a href="https://publications.waset.org/abstracts/search?q=Gamal%20A.%20Mohamed"> Gamal A. Mohamed</a>, <a href="https://publications.waset.org/abstracts/search?q=Khalid%20Z.%20Alshali"> Khalid Z. Alshali</a>, <a href="https://publications.waset.org/abstracts/search?q=Zainy%20M.%20Banjar"> Zainy M. Banjar</a>, <a href="https://publications.waset.org/abstracts/search?q=Hany%20A.%20El-Bassossy"> Hany A. El-Bassossy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hypertension and vascular dysfunction are major components and complications of many diseases like metabolic syndrome. In addition, vascular dysfunction is considered the initial step in diabetic atherosclerosis, the main etiology for mortality and a great percent of morbidity in diabetic patients. In spite of the significant developments in antidiabetic therapy, diabetic complications, particularly seen in long-term diabetes, continue to be seriously deleterious. Herbal drugs are prescribed widely in treatment of different aliment because of their effectiveness, fewer side effects and relatively low cost. Nine plants belong to five different families grown in Kingdom of Saudi Arabia were evaluated for their effect on exaggerated vasoconstriction and impaired relaxation in aortae isolated from metabolic syndrome rats. The aerial parts of Onopordum ambiguum Fresen. (OA), Astragalus abyssinicus Steud. (AA), Pulicaria Arabica Cass. (PA), Echinops sheilae Kit Tan (ES), Aizoon canariense L. (AC), Cleome viscosa L. (CV), Chrozophora oblongifolia (Delile) A.Juss. ex Spreng (CO), Centaurea pseudosinaica Mouterde (CP) and Tephrosia nubica Baker (TN) were dried and extracted with methanol. The effect of thirty minute incubation with the total extracts (10-330 碌g/ml) or their fractions on the exaggerated vasoconstriction response to phenylephrine (10nM to 10microM) and impaired vasodilation to acetylcholine (10-330 碌g /ml) of aortae isolated from metabolic syndrome animals was studied. Incubating aortae isolated from metabolic syndrome animals with total methanol extract of OA, AA, PA, AC, CV, and TN at concentrations (10-330 microgram/ml) in the organ bath led to concentration dependent alleviation of exaggerated vasoconstriction response to phenylephrine without having beneficial effect on impaired vasodilation to acetylcholine. In conclusion, addition of OA, AA, PA, AC, CV and TN to the standard therapies may provide superior means to alleviate the associated vascular complications. <iframe src="https://publications.waset.org/abstracts/50059.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=vascular%20dysfunction" title="vascular dysfunction">vascular dysfunction</a>, <a href="https://publications.waset.org/abstracts/search?q=exaggerated%20vasoconstriction" title=" exaggerated vasoconstriction"> exaggerated vasoconstriction</a>, <a href="https://publications.waset.org/abstracts/search?q=metabolic%20syndrome" title=" metabolic syndrome"> metabolic syndrome</a>, <a href="https://publications.waset.org/abstracts/search?q=Saudi%20plants" title=" Saudi plants"> Saudi plants</a> </p> <a href="https://publications.waset.org/abstracts/50059/screening-of-some-saudi-plants-for-their-alleviating-effect-on-the-exaggerated-vasoconstriction-in-metabolic-syndrome" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50059.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">279</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational 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Screening of Some Saudi Plants for Their Alleviating Effect on the Exaggerated Vasoconstriction in Metabolic Syndrome