Why using COAs and DHTs together is the future of clinical research

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Though both COAs and DHTs are tools used to evaluate a treatment’s impact, they often exist in separate spheres, rarely integrated. We argue that combining these two approaches in the same study can help researchers gather better data and improve the likelihood of regulatory approval.</p></div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="ff049863-8e3b-4500-a40c-dc0573b8ed30"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h3> COAs and DHTs: Advantages and limitations </h3> <div><p>COAs are typically questionnaires completed by a patient or their clinician, allowing researchers to capture how a treatment impacts a patient's quality-of-life and health. However, COAs are subjective. They rely on the patients’ ability to recall their symptoms accurately. How a patient experiences their condition, and how they reflect these experiences in the questionnaire may vary depending on how they feel when completing it. </p><p>DHTs collect health data through wearable devices, digital sensors, and mobile apps which provide objective health data that can offer unique insights. The data is robust and unbiased. However, DHTs cannot capture the impact of the changes in these datapoints on the patients’ quality of life. </p></div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="3dbd5afa-43c0-447d-a9d5-6e37f0ddfb9f"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h3> The case for using both COAs and DHTs in the same study </h3> <div><p>Despite their individual strengths, the synergy between these approaches remains largely unexplored. There are many benefits to gain from using both tools within the same clinical trial. They provide complementary insights, filling any gaps in data that may result from using either one alone.</p><p>When used together in the same study COAs and DHTs have the potential to be better than the sum of their parts. To illustrate the possibilities of combining this powerful duo imagine researchers designing a clinical trial for a major new type 2 diabetes drug. The team wants to validate the drug and give regulators sufficient data for approval. They also want to use a diverse set of the diabetic patient population.</p><p>Some clinical trial teams in this position would recruit patients and give them a weekly questionnaire. This would ask them about their diabetes symptoms and the impact of diabetes on their daily activities. The trial team gets great patient quality of life data, but ultimately that data is limited. Patients’ recall of the previous week may not be accurate, or they may bias their answers based on how they feel when answering the questionnaire. The nature of this subjective data also makes it difficult to gauge how patients’ blood glucose levels impact these symptoms. They measure how the patients subjectively feel, but how are those subjective feelings influenced in real time by their glucose levels? These limitations leave the clinical team with an incomplete picture of the drug's effects and may decrease the likelihood of regulatory approval.</p><p>Other clinical trial teams might choose to give patients a continuous glucose monitor device that tracks their glucose levels throughout the day. This gives the team precise, real-time data on how patients’ glucose levels change. But it doesn't capture the broader impact of how those changes impact the patients' quality of life. Glucose readings may improve, but what is the impact on the patients’ quality of life? </p><p>In this hypothetical case, the team decides to measure both the medication's impact on patients’ glucose levels and its impact on patients' feelings of fatigue throughout the day. They select a patient-reported outcome that asks patients about their energy levels and physical limitations. In tandem, the study team selects a continuous glucose monitor device that tracks patients’ glucose levels throughout the day. As the trial progresses, the team has objective data on patients’ glucose levels as well as the weekly questionnaire data that provides data on how patients feel. The team could choose to deliver the COAs through a mobile app, allowing patients to participate remotely. This opens up the study to a more diverse set of participants. </p><p>As data is analysed, the continuous glucose monitor DHT shows that patients in the trial have significant improvements in their glucose levels. In addition, the COA questionnaire data reveals that patients also experience higher energy levels and fewer side effects than other treatment options. This comprehensive data helps the clinical trial move confidently towards regulatory approval and real-world use. </p></div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="c70e31be-3815-455a-b286-887e8e01ca27"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h3> The future of patient outcomes measurement </h3> <div><p>Although this study is hypothetical today, it may not be so for long. In the future this practice may become the norm. Advances in digital health technologies and more robust tools like those offered in <a href="https://www.iconplc.com/solutions/outcome-measures">ICON's Outcome Measures</a> service are enabling more clinical trials to use COAs and DHTs side by side. This integration of COAs and DHTs in clinical trials represents a significant breakthrough in our ability to capture a holistic view of treatments’ impacts. By combining patient-reported outcomes with real-time, objective health data, researchers can paint a more complete picture of a drug's efficacy. </p><p>Using both COA and DHT data addresses the limitations of using either method alone. COAs provide crucial insights into patients' quality of life but may be subject to recall bias, while DHTs offer precise, continuous data but lack context regarding patient experiences. The synergy between these tools only enhances the quality and depth of data collected. It also enables more diverse patient population participation through remote access tools. Ultimately, this comprehensive approach strengthens the case for regulatory approval and paves the way for more effective, patient-centric treatments.</p></div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="05751269-7f07-4752-86a2-aea3b882a037"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper") }}> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h3> Conclusion </h3> <div><p>As we look to the future of clinical research, the combined use of COAs and DHTs stands out as a game-changing strategy. This approach yields richer, more nuanced data and aligns closely with <a href="https://www.iconplc.com/insights/blog/2024/09/02/outcome-measures-driving-forward-patient-centered-clinical-trials">the growing emphasis on patient-centered outcomes in healthcare</a>. By bridging the gap between objective measurements and subjective experiences, researchers can develop a deeper understanding of treatment effects, leading to more targeted and effective therapies. As technology continues to advance and services like ICON's Outcome Measures evolve, we anticipate a new era of drug development characterised by faster approvals and more personalised treatments. Ultimately this will lead to better outcomes for patients worldwide.</p><h6>By: Don Tomes, Product Manager (formerly HumanFirst)</h6></div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="container-fluid container-fluid--xl"> <div id="26fef036-775a-40f2-9025-8e80a55782bf" class="cta text-left mb-5"> <h2>Partner with ICON</h2> <div><p>Access greater intelligence to select and use the measures that matter in your clinical research. </p></div> <a href="/contact" class="btn btn-primary btn-md" target="_self">Contact us</a> </div> </div> </div> </second> </div> <div class="col-md-3 order-1"> <div id="a446fff2-a136-4b5a-b044-076880c467a8"> <div class="container-fluid container-fluid--xl sidebar-menu-wrapper"> <div class="sidebar"> <div class="sidebar sidebar--sticky sidebar--collapsible"> <a class="sidebar--collapsible__toggle collapsed" role="button" data-toggle="collapse" href="#sidebar-content" aria-expanded="false" aria-controls="sidebar-content"> <span>In this section</span> </a> <div class="sidebar--collapsible__content collapse" id="sidebar-content"> <div class="sidebar--menu"> <h6 class="d-none d-md-block">In this section</h6> <ul class="sidebar--collapsible__list"> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#digital-disruption-10590"></span> <a href="/insights/digital-disruption" data-drupal-link-system-path="node/33613">Digital Disruption</a> <div class="collapse " id="digital-disruption-10590" > <ul class="menu menu-level-1"> <li> <a href="/insights/digital-disruption/clinical-strategies-optimise-samd-treating-mental-health" data-drupal-link-system-path="node/41446">Clinical strategies to optimise SaMD for treating mental health</a> <div class="collapse " id="digital-disruption-clinical-strategies-to-optimise-samd-for-treating-mental-health-11581" > </div> </li> <li> <a href="/insights/digital-disruption/digital-disruption-whitepaper" data-drupal-link-system-path="node/41496">Digital Disruption whitepaper</a> <div class="collapse " id="digital-disruption--digital-disruption-whitepaper-11606" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#digital-disruption---ai-and-clinical-trials-10591"></span> <a href="/insights/digital-disruption/ai-insights" data-drupal-link-system-path="node/33606">AI and clinical trials</a> <div class="collapse " id="digital-disruption---ai-and-clinical-trials-10591" > <ul class="menu menu-level-2"> <li> <a href="/insights/digital-disruption/ai-and-clinical-trials/impact-of-ai-on-outcomes-based-contracting" data-drupal-link-system-path="node/33605">Impact of AI on Outcomes Based Contracting</a> <div class="collapse " id="ai-and-clinical-trials-impact-of-ai-on-outcomes-based-contracting-10592" > </div> </li> <li> <a href="/insights/digital-disruption/ai-and-clinical-trials/using-ai-for-site-id-and-selection" data-drupal-link-system-path="node/33607">Using AI for site ID and selection</a> <div class="collapse " id="ai-and-clinical-trials--using-ai-for-site-id-and-selection-10593" > </div> </li> <li> <a href="/insights/digital-disruption/ai-and-clinical-trials/applying-ai-manage-risks-and-costs-postmarketing" data-drupal-link-system-path="node/40261">Applying AI to manage the risks and costs of postmarketing requirements</a> <div class="collapse " id="ai-and-clinical-trials---applying-ai-to-manage-the-risks-and-costs-of-postmarketing-requirements-11291" > </div> </li> </ul> </div> </li> <li> <a href="/insights/digital-disruption/anonymisation-of-sdtm-for-data-sharing" data-drupal-link-system-path="node/33608">Clinical trial data anonymisation and data sharing</a> <div class="collapse " id="digital-disruption----clinical-trial-data-anonymisation-and-data-sharing-10594" > </div> </li> <li> <a href="/insights/digital-disruption/ai-icon" data-drupal-link-system-path="node/41646">AI at ICON</a> <div class="collapse " id="digital-disruption-----ai-at-icon-11651" > </div> </li> <li> <a href="/insights/digital-disruption/clinical-trial-tokenisation" data-drupal-link-system-path="node/33609">Clinical Trial Tokenisation</a> <div class="collapse " id="digital-disruption------clinical-trial-tokenisation-10595" > </div> </li> <li> <a href="/insights/digital-disruption/closing-the-evidence-gap-the-value-of-digital-health-technologies-in-supporting-drug-reimburement-decisions" data-drupal-link-system-path="node/33610">Closing the evidence gap: The value of digital health technologies in supporting drug reimbursement decisions</a> <div class="collapse " id="digital-disruption-------closing-the-evidence-gap-the-value-of-digital-health-technologies-in-supporting-drug-reimbursement-decisions-10596" > </div> </li> <li> <a href="/insights/digital-disruption/digital-disruption-in-biopharma" data-drupal-link-system-path="node/33611">Digital disruption in biopharma</a> <div class="collapse " id="digital-disruption--------digital-disruption-in-biopharma-10597" > </div> </li> <li> <a href="/insights/digital-disruption/disruptive-innovation" data-drupal-link-system-path="node/33612">Disruptive Innovation</a> <div class="collapse " id="digital-disruption---------disruptive-innovation-10598" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#digital-disruption----------remote-patient-monitoring-10599"></span> <a href="/insights/digital-disruption/mHealth-wearables" data-drupal-link-system-path="node/33618">Remote Patient Monitoring</a> <div class="collapse " id="digital-disruption----------remote-patient-monitoring-10599" > <ul class="menu menu-level-2"> <li> <a href="/insights/digital-disruption/remote-patient-monitoring/bring-your-own-device" data-drupal-link-system-path="node/33614">Bring Your Own Device</a> <div class="collapse " id="remote-patient-monitoring-bring-your-own-device-10600" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#remote-patient-monitoring--cybersecurity-10601"></span> <a href="/insights/digital-disruption/remote-patient-monitoring/cybersecurity" data-drupal-link-system-path="node/33616">Cybersecurity</a> <div class="collapse " id="remote-patient-monitoring--cybersecurity-10601" > <ul class="menu menu-level-3"> <li> <a href="/insights/digital-disruption/mHealth-wearables/cybersecurity/cybersecurity-checklist" data-drupal-link-system-path="node/33615">Addressing cybersecurity for your medical device</a> <div class="collapse " id="cybersecurity-addressing-cybersecurity-for-your-medical-device-10602" > </div> </li> </ul> </div> </li> <li> <a href="/insights/digital-disruption/mHealth-wearables/digital-endpoints" data-drupal-link-system-path="node/33617">Digital Endpoints</a> <div class="collapse " id="remote-patient-monitoring---digital-endpoints-10603" > </div> </li> <li> <a href="/insights/digital-disruption/remote-patient-monitoring/transforming-medical-device-development" data-drupal-link-system-path="node/33619">Transforming Medical Device Development with mHealth</a> <div class="collapse " id="remote-patient-monitoring----transforming-medical-device-development-with-mhealth-10604" > </div> </li> </ul> </div> </li> <li> <a href="/insights/digital-disruption/personalising-digital-health" data-drupal-link-system-path="node/33620">Personalising Digital Health</a> <div class="collapse " id="digital-disruption-----------personalising-digital-health-10605" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#digital-disruption------------real-world-data-10606"></span> <a href="/insights/digital-disruption/real-world-data" data-drupal-link-system-path="node/33621">Real World Data</a> <div class="collapse " id="digital-disruption------------real-world-data-10606" > <ul class="menu menu-level-2"> <li> <a href="/insights/digital-disruption/real-world-data/maximise-rwe-value" data-drupal-link-system-path="node/33622">Harnessing technology to maximise Real World Evidence value</a> <div class="collapse " id="real-world-data-harnessing-technology-to-maximise-real-world-evidence-value-10607" > </div> </li> <li> <a href="/insights/digital-disruption/real-world-data/meeting-evidentiary-needs" data-drupal-link-system-path="node/33623">Meeting Evidentiary Needs with EHRs</a> <div class="collapse " id="real-world-data--meeting-evidentiary-needs-with-ehrs-10608" > </div> </li> <li> <a href="/insights/digital-disruption/real-world-data/post-market-surveillance" data-drupal-link-system-path="node/33624">Post-Market Surveillance for Medical Devices</a> <div class="collapse " id="real-world-data---post-market-surveillance-for-medical-devices-10609" > </div> </li> </ul> </div> </li> <li> <a href="/insights/digital-disruption/triad-trust-navigating-real-world-healthcare-data-integration" data-drupal-link-system-path="node/40066">The triad of trust: Navigating real-world healthcare data integration</a> <div class="collapse " id="digital-disruption-------------the-triad-of-trust-navigating-real-world-healthcare-data-integration-11271" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#patient-centricity-10610"></span> <a href="/insights/patient-centricity" data-drupal-link-system-path="node/33633">Patient Centricity</a> <div class="collapse " id="patient-centricity-10610" > <ul class="menu menu-level-1"> <li> <a href="/insights/patient-centricity/agile-clinical-monitoring" data-drupal-link-system-path="node/33626">Agile Clinical Monitoring</a> <div class="collapse " id="patient-centricity-agile-clinical-monitoring-10611" > </div> </li> <li> <a href="/insights/patient-centricity/capturing-the-voice-of-the-patient-in-clinical-trials" data-drupal-link-system-path="node/33627">Capturing the voice of the patient in clinical trials</a> <div class="collapse " id="patient-centricity--capturing-the-voice-of-the-patient-in-clinical-trials-10612" > </div> </li> <li> <a href="/insights/patient-centricity/charting-the-managed-access-program" data-drupal-link-system-path="node/33628">Charting the Managed Access Program Landscape</a> <div class="collapse " id="patient-centricity---charting-the-managed-access-program-landscape-10613" > </div> </li> <li> <a href="/insights/patient-centricity/developing-nurse-centric-medical-communications" data-drupal-link-system-path="node/33629">Developing Nurse-Centric Medical Communications</a> <div class="collapse " id="patient-centricity----developing-nurse-centric-medical-communications-10614" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#patient-centricity-----diversity-and-inclusion-in-clinical-trials-10615"></span> <a href="/insights/patient-centricity/diversity-and-inclusion-clinical-trials" data-drupal-link-system-path="node/33631">Diversity and inclusion in clinical trials</a> <div class="collapse " id="patient-centricity-----diversity-and-inclusion-in-clinical-trials-10615" > <ul class="menu menu-level-2"> <li> <a href="/insights/patient-centricity/diversity-and-inclusion-in-clinical-trials/diversity-and-inclusion-in-clinical-trials-whitepaper" data-drupal-link-system-path="node/33630">Diversity and inclusion in clinical trials whitepaper</a> <div class="collapse " id="diversity-and-inclusion-in-clinical-trials-diversity-and-inclusion-in-clinical-trials-whitepaper-10616" > </div> </li> </ul> </div> </li> <li> <a href="/insights/patient-centricity/exploring-the-patient-perspective-from-different-angles" data-drupal-link-system-path="node/33632">Exploring the patient perspective from different angles</a> <div class="collapse " id="patient-centricity------exploring-the-patient-perspective-from-different-angles-10617" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#patient-centricity-------patient-safety-and-pharmacovigilance-10618"></span> <a href="/insights/patient-centricity/patient-safety-and-pharmacovigilance" data-drupal-link-system-path="node/33635">Patient safety and pharmacovigilance</a> <div class="collapse " id="patient-centricity-------patient-safety-and-pharmacovigilance-10618" > <ul class="menu menu-level-2"> <li> <a href="/insights/patient-centricity/patient-safety-and-pharmacovigilance/a-guide-to-safety-data-migrations" data-drupal-link-system-path="node/33634">A guide to safety data migrations</a> <div class="collapse " id="patient-safety-and-pharmacovigilance-a-guide-to-safety-data-migrations-10619" > </div> </li> <li> <a href="/insights/patient-centricity/patient-safety-and-pharmacovigilance/taking-safety-reporting-next-level" data-drupal-link-system-path="node/33636">Taking safety reporting to the next level with automation</a> <div class="collapse " id="patient-safety-and-pharmacovigilance--taking-safety-reporting-to-the-next-level-with-automation-10620" > </div> </li> <li> <a href="/insights/patient-centricity/patient-safety-and-pharmacovigilance/outsourced-pharmacovigilance" data-drupal-link-system-path="node/33637">Outsourced Pharmacovigilance Affiliate Solution</a> <div class="collapse " id="patient-safety-and-pharmacovigilance---outsourced-pharmacovigilance-affiliate-solution-10621" > </div> </li> <li> <a href="/insights/patient-centricity/patient-safety-and-pharmacovigilance/evolution-pharmacovigilance-system" data-drupal-link-system-path="node/33638">The evolution of the Pharmacovigilance System Master File: Benefits, challenges, and opportunities</a> <div class="collapse " id="patient-safety-and-pharmacovigilance----the-evolution-of-the-pharmacovigilance-system-master-file-benefits-challenges-and-opportunities-10622" > </div> </li> <li> <a href="/insights/patient-centricity/patient-safety-and-pharmacovigilance/sponsor-and-cro-pharmacovigilance-and-safety-alliances" data-drupal-link-system-path="node/33639">Sponsor and CRO pharmacovigilance and safety alliances</a> <div class="collapse " id="patient-safety-and-pharmacovigilance-----sponsor-and-cro-pharmacovigilance-and-safety-alliances-10623" > </div> </li> <li> <a href="/insights/patient-centricity/patient-safety-and-pharmacovigilance/understanding-the-periodic-benefit-risk-evaluation-report" data-drupal-link-system-path="node/33640">Understanding the Periodic Benefit-Risk Evaluation Report</a> <div class="collapse " id="patient-safety-and-pharmacovigilance------understanding-the-periodic-benefit-risk-evaluation-report-10624" > </div> </li> </ul> </div> </li> <li> <a href="/insights/patient-centricity/patient-voice-survey" data-drupal-link-system-path="node/33642">Patient voice survey</a> <div class="collapse " id="patient-centricity--------patient-voice-survey-10625" > </div> </li> <li> <a href="/insights/patient-centricity/patient-voice-survey-decentralised-and-hybrid-trials" data-drupal-link-system-path="node/33641">Patient Voice Survey - Decentralised and Hybrid Trials</a> <div class="collapse " id="patient-centricity---------patient-voice-survey-decentralised-and-hybrid-trials-10626" > </div> </li> <li> <a href="/insights/patient-centricity/reimagining-patient-centricity-with-the-iomt" data-drupal-link-system-path="node/33643">Reimagining Patient-Centricity with the Internet of Medical Things (IoMT)</a> <div class="collapse " id="patient-centricity----------reimagining-patient-centricity-with-the-internet-of-medical-things-iomt--10627" > </div> </li> <li> <a href="/insights/patient-centricity/using-longitudinal-qualitative-research-to-capture-the-patient-voice" data-drupal-link-system-path="node/33644">Using longitudinal qualitative research to capture the patient voice</a> <div class="collapse " id="patient-centricity-----------using-longitudinal-qualitative-research-to-capture-the-patient-voice-10628" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#regulatory-intelligence-10629"></span> <a href="/insights/regulatory-intelligence" data-drupal-link-system-path="node/33659">Regulatory Intelligence</a> <div class="collapse " id="regulatory-intelligence-10629" > <ul class="menu menu-level-1"> <li> <a href="/insights/regulatory/an-innovative-approach-to-rare-disease-clinical-development" data-drupal-link-system-path="node/33646">An innovative approach to rare disease clinical development</a> <div class="collapse " id="regulatory-intelligence-an-innovative-approach-to-rare-disease-clinical-development-10630" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#regulatory-intelligence--eu-clinical-trials-regulation-10631"></span> <a href="/insights/regulatory-intelligence/eu-clinical-trials-regulation" data-drupal-link-system-path="node/33650">EU Clinical Trials Regulation</a> <div class="collapse " id="regulatory-intelligence--eu-clinical-trials-regulation-10631" > <ul class="menu menu-level-2"> <li> <a href="/insights/regulatory/eu-ctr/ema-guideline-on-computerised-systems-and-electronic-data" data-drupal-link-system-path="node/33648">EMA guideline on computerised systems and electronic data in clinical trials</a> <div class="collapse " id="eu-clinical-trials-regulation-ema-guideline-on-computerised-systems-and-electronic-data-in-clinical-trials-10632" > </div> </li> <li> <a href="/insights/regulatory/eu-ctr/eu-clinical-trials-regulation" data-drupal-link-system-path="node/33649">EU CTR Whitepaper</a> <div class="collapse " id="eu-clinical-trials-regulation--eu-ctr-whitepaper-10633" > </div> </li> </ul> </div> </li> <li> <a href="/insights/regulatory-intelligence/accelerate-regulatory-document-writing" data-drupal-link-system-path="node/33645">Using innovative tools and lean writing processes to accelerate regulatory document writing</a> <div class="collapse " id="regulatory-intelligence---using-innovative-tools-and-lean-writing-processes-to-accelerate-regulatory-document-writing-10634" > </div> </li> <li> <a href="/insights/regulatory-intelligence/current-overview-data-sharing-within-clinical-trial-transparency" data-drupal-link-system-path="node/33647">Current overview of data sharing within clinical trial transparency</a> <div class="collapse " id="regulatory-intelligence----current-overview-of-data-sharing-within-clinical-trial-transparency-10635" > </div> </li> <li> <a href="/insights/regulatory/global-agency-meetings" data-drupal-link-system-path="node/33658">Global Agency Meetings: A collaborative approach to drug development</a> <div class="collapse " id="regulatory-intelligence-----global-agency-meetings-a-collaborative-approach-to-drug-development-10643" > </div> </li> <li> <a href="/insights/regulatory-intelligence/keeping-end-mind-key-considerations-creating-plain-language" data-drupal-link-system-path="node/33660">Keeping the end in mind: key considerations for creating plain language summaries</a> <div class="collapse " id="regulatory-intelligence------keeping-the-end-in-mind-key-considerations-for-creating-plain-language-summaries-10644" > </div> </li> <li> <a href="/insights/regulatory-intelligence/navigating-orphan-drug-development-early-phase-marketing" data-drupal-link-system-path="node/33661">Navigating orphan drug development from early phase to marketing authorisation</a> <div class="collapse " id="regulatory-intelligence-------navigating-orphan-drug-development-from-early-phase-to-marketing-authorisation-10645" > </div> </li> <li> <a href="/insights/regulatory-intelligence/procedural-and-regulatory-know-how-china-biotechs-eu" data-drupal-link-system-path="node/33662">Procedural and regulatory know-how for China biotechs in the EU</a> <div class="collapse " id="regulatory-intelligence--------procedural-and-regulatory-know-how-for-china-biotechs-in-the-eu-10646" > </div> </li> <li> <a href="/insights/regulatory/race-act" data-drupal-link-system-path="node/33663">RACE for Children Act</a> <div class="collapse " id="regulatory-intelligence---------race-for-children-act-10647" > </div> </li> <li> <a href="/insights/regulatory/regulatory-considerations-for-biotech" data-drupal-link-system-path="node/33665">Early engagement and regulatory considerations for biotech</a> <div class="collapse " id="regulatory-intelligence----------early-engagement-and-regulatory-considerations-for-biotech-10649" > </div> </li> <li> <a href="/insights/regulatory-intelligence/regulatory-intelligence-newsletter" data-drupal-link-system-path="node/33666">Regulatory Intelligence Newsletter</a> <div class="collapse " id="regulatory-intelligence-----------regulatory-intelligence-newsletter-10650" > </div> </li> <li> <a href="/insights/regulatory-intelligence/requirements-strategy-considerations-within-clinical-trial" data-drupal-link-system-path="node/33667">Requirements & strategy considerations within clinical trial transparency</a> <div class="collapse " id="regulatory-intelligence------------requirements-strategy-considerations-within-clinical-trial-transparency-10651" > </div> </li> <li> <a href="/insights/regulatory/spotlight-on-regulatory-reforms-in-china" data-drupal-link-system-path="node/33668">Spotlight on regulatory reforms in China</a> <div class="collapse " id="regulatory-intelligence-------------spotlight-on-regulatory-reforms-in-china-10652" > </div> </li> <li> <a href="/insights/regulatory-intelligence/demystifying-eu-ctr-mdr-and-ivdr" data-drupal-link-system-path="node/41206">Demystifying EU CTR, MDR and IVDR</a> <div class="collapse " id="regulatory-intelligence--------------demystifying-eu-ctr-mdr-and-ivdr-11541" > </div> </li> <li> <a href="/insights/regulatory-intelligence/transfer-marketing-authorisation" data-drupal-link-system-path="node/33669">Transfer of marketing authorisation</a> <div class="collapse " id="regulatory-intelligence---------------transfer-of-marketing-authorisation-10653" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights-10654"></span> <a href="/insights/therapeutics" data-drupal-link-system-path="node/33684">Therapeutics insights</a> <div class="collapse " id="therapeutics-insights-10654" > <ul class="menu menu-level-1"> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights-endocrine-and-metabolic-disorders-11081"></span> <a href="/insights/therapeutics/endocrine-and-metabolic-disorders" data-drupal-link-system-path="node/39061">Endocrine and Metabolic Disorders</a> <div class="collapse " id="therapeutics-insights-endocrine-and-metabolic-disorders-11081" > <ul class="menu menu-level-2"> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#endocrine-and-metabolic-disorders-obesity-10573"></span> <a href="/insights/therapeutics/endocrine-and-metabolic-disorders/obesity" data-drupal-link-system-path="node/33696">Obesity</a> <div class="collapse " id="endocrine-and-metabolic-disorders-obesity-10573" > <ul class="menu menu-level-3"> <li> <a href="/insights/therapeutics/endocrine-and-metabolic-disorders/obesity/addressing-obesitys-impact" data-drupal-link-system-path="node/33695">Addressing obesity's impact across the disease spectrum</a> <div class="collapse " id="obesity-addressing-obesity-s-impact-across-the-disease-spectrum-10574" > </div> </li> <li> <a href="/insights/therapeutics/endocrine-and-metabolic-disorders/obesity/trends-and-challenges-in-obesity-research" data-drupal-link-system-path="node/33697">Trends and challenges in obesity research and clinical trials</a> <div class="collapse " id="obesity--trends-and-challenges-in-obesity-research-and-clinical-trials-10575" > </div> </li> </ul> </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights--cardiovascular-10655"></span> <a href="/insights/therapeutics/cardiovascular" data-drupal-link-system-path="node/33670">Cardiovascular</a> <div class="collapse " id="therapeutics-insights--cardiovascular-10655" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/cardiovascular/mitigating-the-impact-of-covid19-on-cardiovascular-trials" data-drupal-link-system-path="node/33671">Mitigating the impact of COVID-19 on cardiovascular trials</a> <div class="collapse " id="cardiovascular-mitigating-the-impact-of-covid-19-on-cardiovascular-trials-10656" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights---cell-and-gene-therapies-10657"></span> <a href="/insights/therapeutics/cell-and-gene-therapies" data-drupal-link-system-path="node/33674">Cell and Gene Therapies</a> <div class="collapse " id="therapeutics-insights---cell-and-gene-therapies-10657" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/cell-and-gene-therapies/approaching-the-car-t-cell-therapy-horizon" data-drupal-link-system-path="node/33672">Approaching the CAR T-cell therapy horizon</a> <div class="collapse " id="cell-and-gene-therapies-approaching-the-car-t-cell-therapy-horizon-10658" > </div> </li> <li> <a href="/insights/therapeutics/cell-and-gene-therapies/cell-and-gene-therapy-clinical-trials" data-drupal-link-system-path="node/33673">Cell and Gene ebook</a> <div class="collapse " id="cell-and-gene-therapies--cell-and-gene-ebook-10659" > </div> </li> <li> <a href="/insights/therapeutics/cell-and-gene-therapies/long-term-follow-up-studies-of-cell-and-gene-therapies" data-drupal-link-system-path="node/33675">Long-term follow-up studies of cell and gene therapies</a> <div class="collapse " id="cell-and-gene-therapies---long-term-follow-up-studies-of-cell-and-gene-therapies-10660" > </div> </li> <li> <a href="/insights/therapeutics/cell-and-gene-therapies/mainstreaming-cell-gene-therapies" data-drupal-link-system-path="node/33676">Mainstreaming Cell & Gene Therapies</a> <div class="collapse " id="cell-and-gene-therapies----mainstreaming-cell-gene-therapies-10661" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights----central-nervous-system-10662"></span> <a href="/insights/therapeutics/central-nervous-system" data-drupal-link-system-path="node/33679">Central Nervous System</a> <div class="collapse " id="therapeutics-insights----central-nervous-system-10662" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/central-nervous-system/a-mind-for-digital-therapeutics" data-drupal-link-system-path="node/33677">A mind for digital therapeutics</a> <div class="collapse " id="central-nervous-system-a-mind-for-digital-therapeutics-10663" > </div> </li> <li> <a href="/insights/therapeutics/central-nervous-system/challenges-and-opportunities-in-traumatic-brain-injury-clinical-trials" data-drupal-link-system-path="node/33678">Challenges and opportunities in traumatic brain injury clinical trials</a> <div class="collapse " id="central-nervous-system--challenges-and-opportunities-in-traumatic-brain-injury-clinical-trials-10664" > </div> </li> <li> <a href="/insights/therapeutics/central-nervous-system/key-considerations-for-parkinsons-disease-trials" data-drupal-link-system-path="node/33680">Challenges and opportunities in Parkinson’s Disease clinical trials</a> <div class="collapse " id="central-nervous-system---challenges-and-opportunities-in-parkinson-s-disease-clinical-trials-10665" > </div> </li> <li> <a href="/insights/therapeutics/central-nervous-system/key-considerations-in-chronic-pain-clinical-trials" data-drupal-link-system-path="node/33681">Key Considerations in Chronic Pain Clinical Trials</a> <div class="collapse " id="central-nervous-system----key-considerations-in-chronic-pain-clinical-trials-10666" > </div> </li> </ul> </div> </li> <li> <a href="/insights/therapeutics/glycomics" data-drupal-link-system-path="node/33683">Glycomics</a> <div class="collapse " id="therapeutics-insights-----glycomics-10668" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights------infectious-diseases-10669"></span> <a href="/insights/therapeutics/infectious-diseases" data-drupal-link-system-path="node/33690">Infectious Diseases</a> <div class="collapse " id="therapeutics-insights------infectious-diseases-10669" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/infectious-diseases/antimicrobial-resistance" data-drupal-link-system-path="node/33685">Antimicrobial Resistance</a> <div class="collapse " id="infectious-diseases-antimicrobial-resistance-10670" > </div> </li> <li> <a href="/therapeutics/therapeutics-insights/infectious-diseases/considerations-strengthening-vaccine" data-drupal-link-system-path="node/33686">Considerations for strengthening vaccine development</a> <div class="collapse " id="infectious-diseases--considerations-for-strengthening-vaccine-development-10671" > </div> </li> <li> <a href="/insights/therapeutics/infectious-diseases/covid-19-vaccine-trials" data-drupal-link-system-path="node/33687">COVID-19 vaccine trials</a> <div class="collapse " id="infectious-diseases---covid-19-vaccine-trials-10672" > </div> </li> <li> <a href="/insights/therapeutics/infectious-diseases/covid-19-vaccines-pass" data-drupal-link-system-path="node/33688">COVID-19 vaccines: Post-authorisation safety surveillance</a> <div class="collapse " id="infectious-diseases----covid-19-vaccines-post-authorisation-safety-surveillance-10673" > </div> </li> <li> <a href="/insights/therapeutics/infectious-diseases/hiv" data-drupal-link-system-path="node/33689">HIV</a> <div class="collapse " id="infectious-diseases-----hiv-10674" > </div> </li> <li> <a href="/insights/therapeutics/infectious-diseases/the-value-of-dynamic-transmission-models" data-drupal-link-system-path="node/33691">The value of dynamic transmission models</a> <div class="collapse " id="infectious-diseases------the-value-of-dynamic-transmission-models-10675" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights-------nash-10677"></span> <a href="/insights/therapeutics/nash" data-drupal-link-system-path="node/33693">NASH</a> <div class="collapse " id="therapeutics-insights-------nash-10677" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/nash/the-voice-of-nash-investigators-in-patient-recruitment" data-drupal-link-system-path="node/33694">The voice of NASH investigators</a> <div class="collapse " id="nash-the-voice-of-nash-investigators-10678" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights--------oncology-10682"></span> <a href="/insights/therapeutics/oncology" data-drupal-link-system-path="node/33698">Oncology</a> <div class="collapse " id="therapeutics-insights--------oncology-10682" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/oncology/icon-survey-report-innovation-oncology" data-drupal-link-system-path="node/40826">ICON survey report: Innovation in Oncology</a> <div class="collapse " id="oncology-icon-survey-report-innovation-in-oncology-11406" > </div> </li> <li> <a href="/insights/therapeutics/oncology/de-risking-clinical-development-precision-medicines" data-drupal-link-system-path="node/40831">De-risking clinical development of precision medicines in oncology</a> <div class="collapse " id="oncology--de-risking-clinical-development-of-precision-medicines-in-oncology-11411" > </div> </li> <li> <a href="/insights/therapeutics/oncology/advances-imaging-biomarkers-estimating-drug-efficacy-tumour" data-drupal-link-system-path="node/41156">Advances in imaging biomarkers: Estimating drug efficacy with tumour growth rate modelling</a> <div class="collapse " id="oncology---advances-in-imaging-biomarkers-estimating-drug-efficacy-with-tumour-growth-rate-modelling-11536" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights---------paediatrics-10683"></span> <a href="/insights/therapeutics/pediatrics" data-drupal-link-system-path="node/33699">Paediatrics</a> <div class="collapse " id="therapeutics-insights---------paediatrics-10683" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/pediatrics/pediatric-risk-assessment-map" data-drupal-link-system-path="node/33700">Paediatric Risk Assessment Map</a> <div class="collapse " id="paediatrics-paediatric-risk-assessment-map-10684" > </div> </li> </ul> </div> </li> <li> <a href="/insights/therapeutics/respiratory" data-drupal-link-system-path="node/40721">Respiratory</a> <div class="collapse " id="therapeutics-insights----------respiratory-11351" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#therapeutics-insights-----------rare-and-orphan-diseases-10685"></span> <a href="/insights/therapeutics/rare-and-orphan-diseases" data-drupal-link-system-path="node/33706">Rare and orphan diseases</a> <div class="collapse " id="therapeutics-insights-----------rare-and-orphan-diseases-10685" > <ul class="menu menu-level-2"> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/advanced-therapies-for-rare-diseases" data-drupal-link-system-path="node/33701">Advanced therapies for rare diseases</a> <div class="collapse " id="rare-and-orphan-diseases-advanced-therapies-for-rare-diseases-10686" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/cross-border-enrollment-of-rare-disease-patients" data-drupal-link-system-path="node/33702">Cross-border enrollment of rare disease patients</a> <div class="collapse " id="rare-and-orphan-diseases--cross-border-enrollment-of-rare-disease-patients-10687" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/crossing-the-finish-line" data-drupal-link-system-path="node/33703">Crossing the finish line: Why effective participation support strategy is critical to trial efficiency and success in rare diseases</a> <div class="collapse " id="rare-and-orphan-diseases---crossing-the-finish-line-why-effective-participation-support-strategy-is-critical-to-trial-efficiency-and-success-in-rare-diseases-10688" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/diversity-equity-and-inclusion-in-rare-disease-trials" data-drupal-link-system-path="node/33704">Diversity, equity and inclusion in rare disease clinical trials</a> <div class="collapse " id="rare-and-orphan-diseases----diversity-equity-and-inclusion-in-rare-disease-clinical-trials-10689" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/identify-and-mitigate-risks-to-rare-disease-clinical-programmes" data-drupal-link-system-path="node/33705">Identify and mitigate risks to rare disease clinical programmes</a> <div class="collapse " id="rare-and-orphan-diseases-----identify-and-mitigate-risks-to-rare-disease-clinical-programmes-10690" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/leveraging-historical-data-for-use-in-rare-disease-trials" data-drupal-link-system-path="node/33707">Leveraging historical data for use in rare disease trials</a> <div class="collapse " id="rare-and-orphan-diseases------leveraging-historical-data-for-use-in-rare-disease-trials-10691" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/natural-history-studies-to-improve-drug-development-in-rare-diseases" data-drupal-link-system-path="node/33708">Natural history studies to improve drug development in rare diseases</a> <div class="collapse " id="rare-and-orphan-diseases-------natural-history-studies-to-improve-drug-development-in-rare-diseases-10692" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/patient-centricity-in-orphan-drug-development" data-drupal-link-system-path="node/33709">Patient Centricity in Orphan Drug Development</a> <div class="collapse " id="rare-and-orphan-diseases--------patient-centricity-in-orphan-drug-development-10693" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/the-key-to-remarkable-rare-disease-registries" data-drupal-link-system-path="node/33710">The key to remarkable rare disease registries</a> <div class="collapse " id="rare-and-orphan-diseases---------the-key-to-remarkable-rare-disease-registries-10694" > </div> </li> <li> <a href="/insights/therapeutics/rare-and-orphan-diseases/therapeutic-spotlight-precision-medicine" data-drupal-link-system-path="node/40986">Therapeutic spotlight: Precision medicine considerations in rare diseases</a> <div class="collapse " id="rare-and-orphan-diseases----------therapeutic-spotlight-precision-medicine-considerations-in-rare-diseases-11466" > </div> </li> </ul> </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#transforming-trials-10695"></span> <a href="/insights/transforming-trials" data-drupal-link-system-path="node/33729">Transforming Trials</a> <div class="collapse " id="transforming-trials-10695" > <ul class="menu menu-level-1"> <li> <a href="/insights/transforming-trials/accelerating-biotech-innovation" data-drupal-link-system-path="node/34264">Accelerating biotech innovation from discovery to commercialisation</a> <div class="collapse " id="transforming-trials-accelerating-biotech-innovation-from-discovery-to-commercialisation-10901" > </div> </li> <li> <a href="/insights/transforming-trials/ensuring-validity-clinical-outcomes-assessment-coa-data-value-rater" data-drupal-link-system-path="node/39731">Ensuring the validity of clinical outcomes assessment (COA) data: The value of rater training</a> <div class="collapse " id="transforming-trials--ensuring-the-validity-of-clinical-outcomes-assessment-coa-data-the-value-of-rater-training-11231" > </div> </li> <li> <a href="/insights/transforming-trials/linguistic-validation-of-clinical-outcomes-assessments" data-drupal-link-system-path="node/34286">Linguistic validation of Clinical Outcomes Assessments</a> <div class="collapse " id="transforming-trials---linguistic-validation-of-clinical-outcomes-assessments-10851" > </div> </li> <li> <a href="/insights/transforming-trials/optimising-biotech-funding" data-drupal-link-system-path="node/39001">Optimising biotech funding</a> <div class="collapse " id="transforming-trials----optimising-biotech-funding-11026" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#transforming-trials-----adaptive-clinical-trials-10696"></span> <a href="/insights/transforming-trials/adaptive-clinical-trials" data-drupal-link-system-path="node/33712">Adaptive clinical trials</a> <div class="collapse " id="transforming-trials-----adaptive-clinical-trials-10696" > <ul class="menu menu-level-2"> <li> <a href="/insights/transforming-trials/adaptive-clinical-trials/faster-path-to-market" data-drupal-link-system-path="node/33711">Adaptive Design: The Faster Path to Market</a> <div class="collapse " id="adaptive-clinical-trials-adaptive-design-the-faster-path-to-market-10697" > </div> </li> </ul> </div> </li> <li> <a href="/insights/transforming-trials/best-practices-to-increase-engagement-with-medical-and-scientific-poster-content" data-drupal-link-system-path="node/33713">Best practices to increase engagement with medical and scientific poster content</a> <div class="collapse " id="transforming-trials------best-practices-to-increase-engagement-with-medical-and-scientific-poster-content-10698" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#transforming-trials-------decentralised-clinical-trials-10701"></span> <a href="/insights/transforming-trials/decentralised-and-hybrid-clinical-trials" data-drupal-link-system-path="node/33718">Decentralised clinical trials</a> <div class="collapse " id="transforming-trials-------decentralised-clinical-trials-10701" > <ul class="menu menu-level-2"> <li> <a href="/insights/transforming-trials/decentralised-and-hybrid-clinical-trials/biopharma-perspective-panel-discussion" data-drupal-link-system-path="node/33716">Biopharma perspective: the promise of decentralised models and diversity in clinical trials</a> <div class="collapse " id="decentralised-clinical-trials-biopharma-perspective-the-promise-of-decentralised-models-and-diversity-in-clinical-trials-10702" > </div> </li> <li> <a href="/insights/transforming-trials/decentralised-and-hybrid-clinical-trials/decentralised-trials-plan" data-drupal-link-system-path="node/33717">Decentralised and Hybrid clinical trials</a> <div class="collapse " id="decentralised-clinical-trials--decentralised-and-hybrid-clinical-trials-10703" > </div> </li> <li> <a href="/insights/transforming-trials/decentralised-and-hybrid-clinical-trials/practical-considerations-in-transitioning-to-dct" data-drupal-link-system-path="node/33719">Practical considerations in transitioning to hybrid or decentralised clinical trials</a> <div class="collapse " id="decentralised-clinical-trials---practical-considerations-in-transitioning-to-hybrid-or-decentralised-clinical-trials-10704" > </div> </li> <li> <a href="/insights/transforming-trials/decentralised-and-hybrid-clinical-trials/regulatory-labyrinth-of-technology" data-drupal-link-system-path="node/33720">Navigating the regulatory labyrinth of technology in decentralised clinical trials</a> <div class="collapse " id="decentralised-clinical-trials----navigating-the-regulatory-labyrinth-of-technology-in-decentralised-clinical-trials-10705" > </div> </li> </ul> </div> </li> <li> <a href="/insights/transforming-trials/ecoa-implementation" data-drupal-link-system-path="node/33721">eCOA implementation</a> <div class="collapse " id="transforming-trials--------ecoa-implementation-10706" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#transforming-trials---------blended-solutions-insights-10707"></span> <a href="/insights/transforming-trials/blended-solutions-insights" data-drupal-link-system-path="node/33723">Blended solutions insights</a> <div class="collapse " id="transforming-trials---------blended-solutions-insights-10707" > <ul class="menu menu-level-2"> <li> <a href="/insights/transforming-trials/functional-model-insights/clinical-trials-in-japan-an-enterprise-growth-and-management-strategy" data-drupal-link-system-path="node/33722">Clinical trials in Japan: An enterprise growth and management strategy</a> <div class="collapse " id="blended-solutions-insights-clinical-trials-in-japan-an-enterprise-growth-and-management-strategy-10708" > </div> </li> <li> <a href="/insights/transforming-trials/functional-model-insights/investments-in-supply-of-cras" data-drupal-link-system-path="node/33724">How investments in supply of CRAs is better than competing with the demand for CRAs</a> <div class="collapse " id="blended-solutions-insights--how-investments-in-supply-of-cras-is-better-than-competing-with-the-demand-for-cras-10709" > </div> </li> <li> <a href="/insights/transforming-trials/functional-model-insights/the-evolution-of-fsp-not-just-for-large-pharma" data-drupal-link-system-path="node/33725">The evolution of FSP: not just for large pharma</a> <div class="collapse " id="blended-solutions-insights---the-evolution-of-fsp-not-just-for-large-pharma-10710" > </div> </li> <li> <a href="/insights/transforming-trials/blended-solutions-insights/embracing-blended-operating-model" data-drupal-link-system-path="node/41091">Embracing a blended operating model</a> <div class="collapse " id="blended-solutions-insights----embracing-a-blended-operating-model-11476" > </div> </li> </ul> </div> </li> <li> <a href="/insights/transforming-trials/implications-of-covid-19-on-statistical-design" data-drupal-link-system-path="node/33726">Implications of COVID-19 on statistical design and analyses of clinical studies</a> <div class="collapse " id="transforming-trials----------implications-of-covid-19-on-statistical-design-and-analyses-of-clinical-studies-10711" > </div> </li> <li> <a href="/insights/transforming-trials/improving-pharma-research-and-development-efficiency" data-drupal-link-system-path="node/33727">Improving pharma R&D efficiency</a> <div class="collapse " id="transforming-trials-----------improving-pharma-r-d-efficiency-10712" > </div> </li> <li> <a href="/insights/transforming-trials/increasing-complexity-and-declining-roi-in-drug-development" data-drupal-link-system-path="node/33728">Increasing Complexity and Declining ROI in Drug Development</a> <div class="collapse " id="transforming-trials------------increasing-complexity-and-declining-roi-in-drug-development-10713" > </div> </li> <li> <a href="/insights/transforming-trials/innovation-in-clinical-trial-methodologies" data-drupal-link-system-path="node/33730">Innovation in Clinical Trial Methodologies</a> <div class="collapse " id="transforming-trials-------------innovation-in-clinical-trial-methodologies-10714" > </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#transforming-trials--------------partnership-insights-10715"></span> <a href="/insights/transforming-trials/partnership-insights" data-drupal-link-system-path="node/33732">Partnership insights</a> <div class="collapse " id="transforming-trials--------------partnership-insights-10715" > <ul class="menu menu-level-2"> <li> <a href="/insights/transforming-trials/partnership-insights/exploring-partnership-culture" data-drupal-link-system-path="node/33731">Exploring partnership culture and its impact on outsourcing and operational strategy</a> <div class="collapse " id="partnership-insights-exploring-partnership-culture-and-its-impact-on-outsourcing-and-operational-strategy-10716" > </div> </li> </ul> </div> </li> <li> <a href="/insights/transforming-trials/risk-based-quality-management" data-drupal-link-system-path="node/33733">Risk Based Quality Management</a> <div class="collapse " id="transforming-trials---------------risk-based-quality-management-10717" > </div> </li> <li> <a href="/insights/transforming-trials/transforming-the-rd-model" data-drupal-link-system-path="node/33735">Transforming the R&D Model to Sustain Growth</a> <div class="collapse " id="transforming-trials----------------transforming-the-r-d-model-to-sustain-growth-10719" > </div> </li> </ul> </div> </li> <li class="sidebar--submenu"> <span aria-controls="sidebar-content" class="collapsed " data-toggle="collapse" role="button" href="#value-based-healthcare-10720"></span> <a href="/insights/value-based-healthcare" data-drupal-link-system-path="node/33746">Value Based Healthcare</a> <div class="collapse " id="value-based-healthcare-10720" > <ul class="menu menu-level-1"> <li> <a href="/insights/value-based-healthcare/strategies-commercialising-oncology-treatments-young-adults" data-drupal-link-system-path="node/40021">Strategies for commercialising oncology treatments for young adults</a> <div class="collapse " id="value-based-healthcare-strategies-for-commercialising-oncology-treatments-for-young-adults-11276" > </div> </li> <li> <a href="/insights/value-based-healthcare/US-payers-and-PROs" data-drupal-link-system-path="node/33758">US payers and PROs</a> <div class="collapse " id="value-based-healthcare--us-payers-and-pros-10721" > </div> </li> <li> <a 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