CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "onlinelibrary.wiley.com",cType: 'managed',cRay: '92709bbc3a5e5e3d',cH: 'HNMVKxGfPR6Xw4POUOI34VYO1mBf4vTq.17tPa9MJvg-1743096549-1.2.1.1-9bz5nVDGWxVG_5gxlU9jdHEtgVBVLM4YePS2ZR1gLdwXHO.SeXRHefKNsMKGXvif',cUPMDTk: "\/doi\/10.1002\/mus.21784?__cf_chl_tk=qSCZJyUZEyt.A3PjVQqEY9V_Lxpw3q4dbtiVFlAohgo-1743096549-1.0.1.1-IPmOSoP31NA.sp9PncmBvxfpgQAXd_Bs3UDaJ.RRkyg",cFPWv: 'b',cITimeS: '1743096549',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1002\/mus.21784?__cf_chl_f_tk=qSCZJyUZEyt.A3PjVQqEY9V_Lxpw3q4dbtiVFlAohgo-1743096549-1.0.1.1-IPmOSoP31NA.sp9PncmBvxfpgQAXd_Bs3UDaJ.RRkyg",md: "a5J1oqKaIGWwBTGDCKSohVWiYA52zEnnJbBHcGT_rL0-1743096549-1.2.1.1-0lcCzd8pGQDqVUcgFhMYazMMEBcfbtawIQMjFlZ5joes0dDPbaWtikyFFA7YuyBLMTShD8OkiRwU7zmJ5_1KhBkQmB89aJiRqF_yyvrDaGniEZTtQzcisLZA1qMS5eOzpxR244ToHeaZF_IMv7ldv6mRu8da_C0IPCqlRk8z_mDxiR1C6vBoDhrFwtNn0u8qhXvx4FfslucKWt1FO_dg67nboTqalrv14p903I20fMzqsKsFSOtWhFzgRgaxRHt6g57UnHwTqf8b7uNOQpYKGx9hlduGaYM5IPRXTo2xFhMXes3KPNsZAS4JmtKUqllI5apF1tWdIjUZVaHQ3ARmEogfQmGM2HSsNNkqH_2lth6G.8EyZuB188ERwrJu3.7Z_Q.TB6nM7Fcx4kWcZP.okw35gHKX.uA83PMoTXGbRduvEsK_VwizHCxNqxBJirs_qBMuf94JQJhsj1.ipco8SY.LYamFtMCvw_0D8Q6cmqYW9E0QQF41Xv93I9Y6S_WEAnmb1vPtyaaKaBU8JU.f8bIOKqManenoEeKA8Z1Ac9iaU8DAY_d.nJwuPd1_.d9SMNiEY_CNQ7mcXQEWFJlNVjd_zTBhr1zDcXCXlf3qwn_PXK1WsqDxbfXfMixwGxEjKGlatp04117kfqenT9YTQpLxK42sNNnnfhRzpQyEsjImghfC4dEBVo9aDWVak1fK9qT4rFWDvOejbjuhQ7Whw7QF6AjEzoUmRgsxRRmSqTD.oV4J6HI3JIga462UQpyQ7HObtyEMzutN2C_dHESk6HxO5N8zlJP1lfT_8F3NTBxM_sew8CC8qCbZnwzvNoOaF78pQ_pr49gvQ8GVt9bvuwk8CrudiBvcI2aeLtgbx6d5dDFZoarsv1KdMId0Z90RzWj9vka3DXWtHngkSGnPsdXdrWJhUizmjOBVP.0WAmEkOytHVOAQMjMzUde_nje50jeJADpjfaOCxpATbb9jqDNUh2y8gvjotI8YLdd3zEXov3ycun4hm8_zOerpEORqzTqy.fEcNYVbjhocBG0_jqHP63wfSxGqrrQZPg4w42KZKW6Q0TPBVIErj0lp44tt6ig4K1xKYLJWQAgQve_5pnYXtnhXVYJGYQTrWQuwyVuRZHBalQhAHcdzipTw.8f0YNVEMkKXOk45Mo4RKDzau87GGSnerGt7QfGEFDA1GXAqpC..W9N3tcomGdvJCdu8AEyhRR63ZJ68SdHGdH0rEmmigg0vFnAciE8Hxf30GBIV7QeuFecshvsBzjdx1VZL4QOuViQ_iPeodAWpUWO1KA",mdrd: "Kv8eUn4KlQIeSxj_09YoS4shjIIUrMGztcLuit8oe5g-1743096549-1.2.1.1-kgI7rjrnL531y7zvlmBd.7QvFN7mTvaHnGifZVE0QXNP3F9K8tqcqrWlv2yX_Ls1vFoDh6NxayTvj8CfLtLnuSja5ayiBSB22OytNN_3XbCNb31xZZ0NnzEyqTH0mdInOIUceo2und4gT21gWmRR5vM_GOWfYtyS9oqXnPxPzx9rrMT1v7QERuE3smVCv4UuNc2eO1CJZUsc0xggj34bHccrhDZ87YwdbNpY0kgOtZLhuk.4qfVCwjJ7bLBzkbzsi7.Z9iEtzQNQi4ug0gEieK9_BEFeIrEORyQihX8cwF43InR2xBCq08nUL1QMU44HIwdc.jIKoN6EMrmN3aXU4aBsI1HdutrQjPqzDKi._0prypCv3w.FhfO6KQkWrvpgfkOu6zSeyLHFcVnwVKkq2wHTy157b5_.ksV36.CR2On1rYzJgyVZ7A8LNdJXypPLnTjPJy7z9kX3H6TUVOMGf81HHQ7aIgHjlGBkGQ_CiXWfqllIB3FrIM52BGkntJZhpISnrH4EiPRs4K7nSvDMfLyjdLfaE7ZctVFjMCHwxPbaKFBlSYZ0LXERkiJkFXTRiSenm4ZbiegRrfwyKeln2SvkoldgYPxYMSZCRS1gnUN7scRqQmr1CHGlrLyitVq.MSS2KjHqOaNhfQDmnDj72kB3wKUfW_ZyIPSY2F8g81d5WiLkbRsYasgK6ivwZq.fhHuB087EFsrHh1m6LdXLqVt43wHI9DUneY6Jvyx7Dn4Fz0IrrT2Tsv9GTEn4VrJbGi_.hOkRge8iVstx7C7gzuBN91q447odd6n2CU6msaiMEkIMk3mXpCd6I957byIHS1rCCTo9PL0obL4JekYzq3e66w9q7SfQ7KIU.LYP99UgOjTmViwkvUa19uOHAKpccbrE.pWpp_mS9uD81ZfJ5fHQJlfGyFeF1kzQjTUZDSw1knyqXM8GiSnNzpR4A6dMwfpM_7opnsVB7jR9ZLiOw.ycb8YZpjeiqELQo1hHQPJnoSOXb7I74BMerszl_yU1OlA9jemRFF7_MCQwd7ja6.SJhQHKMt2ybH9OPR6B6N67QjNq4.u6TbytgbR7lCptq2yuy5aoKrQaAu3.32irecEtJpLVm142o_hqEbm4IyDTRVZD9jFicVrLaUjSlx92zKIKmh8BgHHbdNKP8qANYPptZeZR.V9Tc4Y43KJenAF7G6NJpdOxPHmVw.AEuyjJWIe2lulJAybOeYtsmThet7ah7HLSrNLDROrFhyDqnSqwk9mkgbLXnJaVCwk573_xs8uJu80sfQImB1ZzlkgYFGFd1Mne7E.rEx4aYKs9MNhbfqiy_E_V5QxnWc9hiP8YmIVtO6qmB5m1WNrJ.Z_rqKhxMahEBvtJHmiQorK4yjTKBMJEHDlY78AtR7D0Da1tIG_U7OhwcHjONA8B1vk.KKRIN8PRvWCbDmUB__d9L6MLT5edHCk6.hfZx.QvoZ1MNPZWGF7bXlN79g66SrnWUVHjIENHFRe8BMVV94hWM8dr4wn8enLNSLx9MA75G2gsAgwBGACnN_iIvWCoCA9cfWXwSeP7ngS7fiwCZiUHGyEm2yE2CwrdyDaafDC9D8b2r4BymWGQXuoMSS5hqh0q3JHefliO4XiqJGd0q4tTN8BLT1NCXB9gdoaAylQQvZRb3zMzYg9DdzOS_2lVdQQA4j_XUeNpWf0nXD4sdBvjyAyde7t7r13ZxQfZJYtj1QMBrcE0Fj0X_..ptRQgwjLH5f32C41PtN5TZ5eUGd3dGoxBZ7nbY4dRrxPtqV6rXTX.9F0CjxDf2KWr5I2Qms8DehW5gNOEo6zLsMlH77J27z4alX3jeSapT8Lnds_OOjEmXLfc3hOPURyFI6nV0vpWK.JRL_oaK8zx__7qms3pa5ZtMTVd20nhPWZzSdZhh9zv2WrlkO6LxUJ1VHqZmsIou30U4oGUDTnOYBjiInlCfAUhj77vV2llfCobjva4FZe6.wsRSpeCG1_Nee8yj3o7CNAEaMeQtjdH7Cdx34EYGDGsB4eMcQTTT5A8MdCjuha3R6mkaRZpYWOMPHtlW_ayopsUZKe5ctBv2dQ8nXGpftg"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=92709bbc3a5e5e3d';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1002\/mus.21784?__cf_chl_rt_tk=qSCZJyUZEyt.A3PjVQqEY9V_Lxpw3q4dbtiVFlAohgo-1743096549-1.0.1.1-IPmOSoP31NA.sp9PncmBvxfpgQAXd_Bs3UDaJ.RRkyg" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>