CINXE.COM

<!doctype html> <html lang="ru"> <head> <title>新型双核 Se-N-杂环卡宾加合物及其唑盐的对接 | 103314</title> <meta name="keywords" content="穆罕默德·阿提夫、曼苏雷·纳扎里五世、穆罕默德·B·哈迪尔·艾哈迈德、阿曼·沙阿·阿卜杜勒·马吉德、玛丽亚姆·阿斯拉姆、穆罕默德·阿德南·伊克巴尔 , "/> <meta name="description" content="使用分子对接方法设计了两种双核硒加合物（5 和 6），同时发现它们与四种血管生成因子蛋白（包括 COX-1（环氧合酶-..103314"/> <meta name="citation_publisher" content="Лонгдом издательская СЛ" /> <meta name="citation_journal_title" content="Ферментная инженерия"> <meta name="citation_title" content="新型双核 Se-N-杂环卡宾加合物及其唑盐的对接设计绿色合成及体外抗癌研究 "> <meta name="citation_author" content="穆罕默德·阿提夫、曼苏雷·纳扎里五世、穆罕默德·B·哈迪尔·艾哈迈德、阿曼·沙阿·阿卜杜勒·马吉德、玛丽亚姆·阿斯拉姆、穆罕默德·阿德南·伊克巴尔" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="12"> <meta name="citation_issue" content="4"> <meta name="citation_abstract" content="使用分子对接方法设计了两种双核硒加合物（5 和 6），同时发现它们与四种血管生成因子蛋白（包括 COX-1（环氧合酶-1）、VEGF-A（血管内皮生长因子 A）、HIF（缺氧诱导因子）和 EGF（人表皮生长因子））有良好的相互作用。随后，使用原位配位方法合成了它们。配位采用绿色合成方法，因为它是在水中而不是有机溶剂中进行的。合成的加合物及其各自的双苯并咪唑盐（2 和 4）通过1 H 和13 C-NMR 以及 FT-IR 光谱进行了确认。随后，使用 MTT 法对这两种化合物进行体外抗癌活性测试，测试其对乳腺癌细胞株 (MCF-7)、宫颈癌细胞株 (Hela)、小鼠黑色素瘤细胞株 (B16F10) 和视网膜神经节细胞株 (RGC-5) 的活性，同时将其活性与市售标准药物 5-氟尿嘧啶进行比较。然而，这两种加合物和双苯并咪唑盐的卓越活性均得到了探索。 "> <meta name="citation_abstract_html_url" content="https://russian.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html"> <meta name="format-detection" content="telephone=no"> <meta http-equiv="Content-Language" content="ru"> <meta name="google-site-verification" content="NomPTP94YozsgvD3NEFpNqUfY88e0TU0L64zNzZTpd0" /> <meta itemprop="name" content="longdom" /> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="ROBOTS" content="INDEX,FOLLOW"> <meta name="googlebot" content="INDEX,FOLLOW"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <link rel="canonical" href="https://russian.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html"> <link rel="alternate" href="https://russian.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" hreflang="ru-RU" />  <link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/css/bootstrap.min.css"> <link href="/assets/css/longdom.css" rel="stylesheet"> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/animate.css/3.7.0/animate.min.css">  <link rel="stylesheet" href="https://use.fontawesome.com/releases/v5.7.1/css/all.css"> <link rel="stylesheet" href="https://maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css">  <link href="https://fonts.googleapis.com/css?family=Montserrat:100,100i,200,200i,300,300i,400,400i,500,500i,600,600i,700,700i,800,800i,900,900i|Open+Sans:300,300i,400,400i,600,600i,700,700i,800,800i|Raleway:100,100i,200,200i,300,300i,400,400i,500,500i,600,600i,700,700i,800,800i,900,900i" rel="stylesheet"> <link href="/assets/css/ionicons.min.css" rel="stylesheet">  <link rel="stylesheet" href="/assets/css/jquery.mCustomScrollbar.min.css"> <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/bootstrap-select/1.13.2/css/bootstrap-select.min.css">  <link rel="stylesheet" href="/assets/css/global.css">  <link rel="stylesheet" href="/assets/css/styles.css"> <link rel="stylesheet" type="text/css" href="/assets/css/author.css"> <link rel="icon" href="/assets/img/favicon.png" type="image/gif"> <link rel="stylesheet" href="/assets/css/coolautosuggest.css">  <script async src="https://www.googletagmanager.com/gtag/js?id=G-GH5GSYYKJG"></script> <script async src="https://pagead2.googlesyndication.com/pagead/js/adsbygoogle.js?client=ca-pub-8046643215361735" crossorigin="anonymous"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-FVE6MN047M'); </script> </head> <body> <header>  <nav class="navbar navbar-expand-lg navbar-light bg-white shadow-sm deva541"> <div class="container"> <a class="navbar-brand" href="https://russian.longdom.org/" title="Нажмите здесь"> <img src="/assets/img/longdom-logo.svg" alt="Logo" height="25"> </a> <button class="navbar-toggler" type="button" data-toggle="collapse" data-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="collapse navbar-collapse justify-content-end" id="navbar"> <div class="navbar-nav"> <a class="nav-item nav-link" href="https://russian.longdom.org/" title="Нажмите здесь">Главная</a> <a class="nav-item nav-link" href="https://russian.longdom.org/open-access-journals-list.html" title="Нажмите здесь">Журналы</a> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle" href="#" id="Guidelines" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Руководства и политики</a> <div class="dropdown-menu" aria-labelledby="Нажмите здесь"> <a class="dropdown-item" href="https://russian.longdom.org/editorial-policies.html" title="Нажмите здесь">Редакционные политики</a> <a class="dropdown-item" href="https://russian.longdom.org/instructions-to-authors.html" title="Нажмите здесь">Инструкции для авторов</a> <a class="dropdown-item" href="https://russian.longdom.org/policies.html" title="Нажмите здесь">Политики</a> <a class="dropdown-item" href="https://russian.longdom.org/publication-ethics.html" title="Нажмите здесь">Этика публикаций</a> <a class="dropdown-item" href="https://russian.longdom.org/reviewers.html" title="Нажмите здесь">Рецензенты</a> <a class="dropdown-item" href="https://russian.longdom.org/terms-conditions.html" title="Нажмите здесь">Условия использования</a> </div> </div> <a class="nav-item nav-link" href="https://russian.longdom.org/advertising.html" title="Нажмите здесь">Реклама</a> <a class="nav-item nav-link" href="https://russian.longdom.org/conferences.html" title="Нажмите здесь">Конференции</a> <a class="nav-item nav-link" href="https://russian.longdom.org/contact-us.html" title="Нажмите здесь">Свяжитесь с нами</a>  <div class="nav-item dropdown multi_lang j_multi_lang"> <a class="nav-link dropdown-toggle" href="#" id="multi_lang" role="button" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">Language</a> <div class="dropdown-menu" aria-labelledby=""> <a class="dropdown-item" href="https://www.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" title="English"> <img src="https://www.longdom.org/admin/flags/usa.png">English </a> <a class="dropdown-item" href="https://spanish.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" title="Spanish"> <img src="https://www.longdom.org/admin/flags/spain.png">Spanish </a> <a class="dropdown-item" href="https://chinese.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" title="Chinese"> <img src="https://www.longdom.org/admin/flags/china.png">Chinese </a> <a class="dropdown-item" href="https://german.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" title="German"> <img src="https://www.longdom.org/admin/flags/germany.png">German </a> <a class="dropdown-item" href="https://french.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" title="French"> <img src="https://www.longdom.org/admin/flags/france.png">French </a> <a class="dropdown-item" href="https://japanese.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" title="Japanese"> <img src="https://www.longdom.org/admin/flags/japan.png">Japanese </a> <a class="dropdown-item" href="https://portuguese.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" title="Portuguese"> <img src="https://www.longdom.org/admin/flags/portugal.png">Portuguese </a> <a class="dropdown-item" href="https://hindi.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" title="Hindi"> <img src="https://www.longdom.org/admin/flags/india.png">Hindi </a> <a class="dropdown-item" href="https://telugu.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" title="Telugu"> <img src="https://www.longdom.org/admin/flags/india.png">Telugu </a> <a class="dropdown-item" href="https://tamil.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" title="Tamil"> <img src="https://www.longdom.org/admin/flags/india.png">Tamil </a> </div> </div>  </div>  </div> </div> </nav> </header>  <section class="bg-info py-1"> <div class="container"> <div class="row align-items-center justify-content-between">  <div class="col-12 col-sm-auto"> <img src="https://www.longdom.org/admin/headers/enzyme-engineering-logo.svg" alt="Ферментная инженерия" width="105" height="105" class="img-fluid mx-auto"> </div> <div class="col-12 col-sm-8"> <h1 class="text-left text-white border-light-blue-200-before font-size-7">Ферментная инженерия<br><small class="float-right font-size-5">Открытый доступ</small></h1> </div>  <div class="col-12 col-sm-2 d-none d-sm-block"> <p class="lead">ISSN: 2329-6674</p>  </div> </div> </div> </section>  <nav id="sticky-navbar" class="navbar navbar-expand-lg navbar-dark bg-primary py-0"> <div class="container"> <button class="navbar-toggler" type="button" data-toggle="collapse" data-target="#jrnlNavbar" aria-controls="jrnlNavbar" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="collapse navbar-collapse justify-content-center" id="jrnlNavbar"> <div class="navbar-nav"> <a class="nav-item nav-link " href="https://russian.longdom.org/enzyme-engineering.html" title="Нажмите здесь">Журнал Главная</a> <a class="nav-link " href="https://russian.longdom.org/enzyme-engineering/aim-and-scope.html" title="Нажмите здесь">Цель и объем</a> <div class="nav-item dropdown"> <a class="nav-link dropdown-toggle " title="Нажмите здесь" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false" href="#">Инструкции для авторов <i class="fas fa-caret-down"></i></a> <div class="dropdown-menu" aria-labelledby="EditorialPanel"> <a class="dropdown-item" href="https://russian.longdom.org/enzyme-engineering/instructionsforauthors.html" title="Нажмите здесь">Инструкции для авторов</a> <a class="dropdown-item" href="https://russian.longdom.org/enzyme-engineering/ethical-malpractices.html" title="Нажмите здесь">Публикационная этика и злоупотребление служебным положением</a> </div> </div> <a class="nav-link " href="https://russian.longdom.org/enzyme-engineering/submit-manuscript.html" title="Нажмите здесь">Отправить рукопись</a> <a class="nav-link " href="https://russian.longdom.org/enzyme-engineering/archive.html" title="Нажмите здесь">Архив</a> <a class="nav-link " href="https://russian.longdom.org/enzyme-engineering/guidelines.html" title="Нажмите здесь">Методические рекомендации</a> <a class="nav-item nav-link " href="https://russian.longdom.org/enzyme-engineering/contact.html" title="Нажмите здесь">Контакт</a> </div> </div> </div> </nav> <section class="py-4 content"> <div class="container"> <div class="row"> <aside class="col-12 col-sm-3 order-last order-sm-first">  <div class="card shadow-sm sidebar mb-3" style="margin-top:10px"> <h6 class="card-header">Поделитесь этой статьей</h6> <div class="card-body"> <nav class="nav social-icons social-icons-sm"> <a class="nav-link bg-facebook white" href="https://www.facebook.com/sharer.php?u=https://russian.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" target="_blank" title="Share with Facebook" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link bg-twitter white" href="https://twitter.com/share?url=https://russian.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" rel="noopener" target="_blank" title="Share with Twitter"><i class="fab fa-twitter"></i></a> <a class="nav-link bg-linkedin white" href="https://www.linkedin.com/shareArticle?mini=true&url=https://russian.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" rel="noopener" target="_blank" title="Share with Linkdin"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link bg-googleplus white" href="https://plus.google.com/share?url=https://russian.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" target="_blank" rel="noopener" title="Share with Google+"><i class="fab fa-google-plus-g"></i></a> <a class="nav-link bg-pinterest white" href="https://pinterest.com/pin/create/button/?url=https://russian.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" rel="noopener" target="_blank" title="Share with Pintrest"><i class="fab fa-pinterest-p"></i></a> <a class="nav-link bg-blogger white" href="https://www.blogger.com/blog-this.g?u=https://russian.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" rel="noopener" target="_blank" title="Share with Blogger"><i class="fab fa-blogger-b"></i></a> </nav> </div> </div> <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header pr-0">Индексировано в</h6> <div class="list-group list-group-flush overflow-view"> <div class="list-group-item p-0 pt-2 pl-2"> <img src="https://www.longdom.org//admin/indexing-logos/academic-keys-16.jpg" alt="Logo" width="50%"> </div> <div class="list-group-item p-0 pt-2 pl-2"> <img src="https://www.longdom.org//admin/indexing-logos/researchbible-18.jpg" alt="Logo" width="50%"> </div> <div class="list-group-item p-0 pt-2 pl-2"> <img src="https://www.longdom.org//admin/indexing-logos/citefactor-33.jpg" alt="Logo" width="50%"> </div> <div class="list-group-item p-0 pt-2 pl-2"> <img src="https://www.longdom.org//admin/indexing-logos/access-to-global-online-research-in-agriculture-agora-46.jpg" alt="Logo" width="50%"> </div> <div class="list-group-item p-0 pt-2 pl-2"> <img src="https://www.longdom.org//admin/indexing-logos/refseek-49.jpg" alt="Logo" width="50%"> </div> <div class="list-group-item p-0 pt-2 pl-2"> <img src="https://www.longdom.org//admin/indexing-logos/directory-of-research-journal-indexing-drji-51.jpg" alt="Logo" width="50%"> </div> <div class="list-group-item p-0 pt-2 pl-2"> <img src="https://www.longdom.org//admin/indexing-logos/hamdard-university-57.jpg" alt="Logo" width="50%"> </div> <div class="list-group-item p-0 pt-2 pl-2"> <img src="https://www.longdom.org//admin/indexing-logos/ebsco-az-58.jpg" alt="Logo" width="50%"> </div> <div class="list-group-item p-0 pt-2 pl-2"> <img src="https://www.longdom.org//admin/indexing-logos/oclc-worldcat-75.jpg" alt="Logo" width="50%"> </div> <div class="list-group-item p-0 pt-2 pl-2"> <img src="https://www.longdom.org//admin/indexing-logos/scholarsteer-77.jpg" alt="Logo" width="50%"> </div> <div class="list-group-item p-0 pt-2 pl-2"> <img src="https://www.longdom.org//admin/indexing-logos/publons-84.png" alt="Logo" width="50%"> </div> <div class="list-group-item p-0 pt-2 pl-2"> <img src="https://www.longdom.org//admin/indexing-logos/euro-pub-123.png" alt="Logo" width="50%"> </div> <div class="list-group-item p-0 pt-2 pl-2"> <img src="https://www.longdom.org//admin/indexing-logos/google-scholar-124.jpg" alt="Logo" width="50%"> </div> </div> <p class="m-0 clearfix"><a href="https://russian.longdom.org/enzyme-engineering/indexing.html" title="Нажмите здесь"><span class="btn btn-warning btn-xs float-right">Посмотреть больше »</span></a></p> </div>   <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header">Полезные ссылки</h6> <div class="card-body p-0"> <nav class="nav flex-column font-size-3 icon-list icon-list-angle-right a-py-1"> <a class="nav-item nav-link" href="https://russian.longdom.org/enzyme-engineering/aim-and-scope.html" title="Нажмите здесь">Цель и объем</a> <a class="nav-item nav-link" href="https://russian.longdom.org/enzyme-engineering/peer-review-process.html" title="Нажмите здесь">Процесс экспертной оценки</a> <a class="nav-item nav-link" href="https://russian.longdom.org/enzyme-engineering/indexing.html" title="Нажмите здесь">Индексирование и архивирование</a> <a class="nav-item nav-link" href="https://russian.longdom.org/enzyme-engineering/archive.html" title="Нажмите здесь">Индексирование и архивирование</a> <a class="nav-item nav-link" href="https://www.longdom.org/submissions/enzyme-engineering.html" title="Нажмите здесь">Отправить рукопись</a> </nav> </div> </div>     <div class="card shadow-sm sidebar mb-3"> <h6 class="card-header">Журналы открытого доступа</h6> <div class="card-body p-0 scroll_mang"> <nav class="nav flex-column font-size-3 icon-list icon-list-angle-right a-py-1"> <a class="nav-item nav-link" href="https://russian.longdom.org/bioinformatics-and-systems-biology-journals.html" title="Нажмите здесь">Биоинформатика и системная биология</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/biochemistry-journals.html" title="Нажмите здесь">Биохимия</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/genetics-and-molecular-biology-journals.html" title="Нажмите здесь">Генетика и молекулярная биология</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/food-and-nutrition-journals.html" title="Нажмите здесь">Еда и питание</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/immunology-and-microbiology-journals.html" title="Нажмите здесь">Иммунология и микробиология</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/engineering-journals.html" title="Нажмите здесь">Инжиниринг</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/clinical-sciences-journals.html" title="Нажмите здесь">Клинические науки</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/medical-sciences-journals.html" title="Нажмите здесь">медицинские науки</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/neuroscience-and-psychology-journals.html" title="Нажмите здесь">Неврология и психология</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/general-science-journals.html" title="Нажмите здесь">Общая наука</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/agri-and-aquaculture-journals.html" title="Нажмите здесь">Сельское хозяйство и аквакультура</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/nursing-and-health-care-journals.html" title="Нажмите здесь">Сестринское дело и здравоохранение</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/business-and-management-journals.html" title="Нажмите здесь">Управление бизнесом</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/pharmaceutical-sciences-journals.html" title="Нажмите здесь">Фармацевтические науки</a><br> <a class="nav-item nav-link" href="https://russian.longdom.org/chemistry-journals.html" title="Нажмите здесь">Химия</a><br> </nav> </div> </div>  </aside> <div class="col-12 col-sm-9"> <h2 class="heading-1">Абстрактный</h2> <h3 class="">新型双核 Se-N-杂环卡宾加合物及其唑盐的对接设计绿色合成及体外抗癌研究 </h3> <p> <i class="fas fa-user"></i> 穆罕默德·阿提夫、曼苏雷·纳扎里五世、穆罕默德·B·哈迪尔·艾哈迈德、阿曼·沙阿·阿卜杜勒·马吉德、玛丽亚姆·阿斯拉姆、穆罕默德·阿德南·伊克巴尔 </p> <p>使用分子对接方法设计了两种双核硒加合物（5 和 6），同时发现它们与四种血管生成因子蛋白（包括 COX-1（环氧合酶-1）、VEGF-A（血管内皮生长因子 A）、HIF（缺氧诱导因子）和 EGF（人表皮生长因子））有良好的相互作用。随后，使用原位配位方法合成了它们。配位采用绿色合成方法，因为它是在水中而不是有机溶剂中进行的。合成的加合物及其各自的双苯并咪唑盐（2 和 4）通过<sup>1</sup> H 和<sup>13</sup> C-NMR 以及 FT-IR 光谱进行了确认。随后，使用 MTT 法对这两种化合物进行体外抗癌活性测试，测试其对乳腺癌细胞株 (MCF-7)、宫颈癌细胞株 (Hela)、小鼠黑色素瘤细胞株 (B16F10) 和视网膜神经节细胞株 (RGC-5) 的活性，同时将其活性与市售标准药物 5-氟尿嘧啶进行比较。然而，这两种加合物和双苯并咪唑盐的卓越活性均得到了探索。</p> <div class="alert alert-info text-left"><b>Отказ от ответственности:</b> Этот тезис был переведен с использованием инструментов искусственного интеллекта и еще не прошел рецензирование или проверку.</div> <div class="nav social-icons"> <a class="nav-link w-auto">Поделитесь этой статьей</a> <a title="Нажмите здесь" target="_blank" href="https://www.facebook.com/sharer.php?u=https://russian.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="Нажмите здесь" target="_blank" href="https://twitter.com/share?url=https://russian.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="Нажмите здесь" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://russian.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="Нажмите здесь" target="_blank" href="https://plus.google.com/share?url=https://russian.longdom.org/abstract/dockingdesigned-green-synthesis-and-eminvitroem-anticancer-studies-of-new-binuclear-senheterocyclic-carbene-adducts-and--103314.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Ссылки на контент</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://russian.longdom.org/privacy-policy.html" title="Нажмите здесь">Политика конфиденциальности</a></li> <li><a class="" href="https://russian.longdom.org/terms-conditions.html" title="Нажмите здесь">Условия использования</a></li> <li><a class="" href="https://russian.longdom.org/authors-reviewers-editors.html" title="Нажмите здесь">Авторы, рецензенты и редакторы</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Связаться с Лонгдом</h4> <p><strong>Longdom Group SA</strong><br /> Авеню Роджера Вандендрише,<br /> 18, 1150 Брюссель, Бельгия<br /> Телефон: +442038085340<br /> <strong>Электронная почта:</strong> <a class="white" href="mailto:info@longdom.org" title="Нажмите здесь">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Соединять</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="Нажмите здесь" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i></a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="Нажмите здесь" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i></a> <a href="https://twitter.com/LongdomP" title="Нажмите здесь" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i></a> <a href="https://www.instagram.com/longdom_publisher/" title="Нажмите здесь" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i></a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>Авторские права © 2024 <a href="https://russian.longdom.org/" title="Нажмите здесь" class="white">Издательство Longdom SL</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? { 'position': 'fixed', 'top': '440px' } : { 'position': 'absolute', 'top': '440px' } ); return fix_element; }()); }); </script>   <script src="https://unpkg.com/feather-icons"></script> <script> feather.replace() </script>  <script src="/assets/js/scroll-to-top.js"></script>  <script type="text/javascript" src="/assets/js/coolautosuggest.js"></script> <script language="javascript" type="text/javascript"> $("#keyword").coolautosuggest({ url: "https://russian.longdom.org/author-names.php?chars=", minChars: 3, }); </script> <script src="/assets/js/jquery.mCustomScrollbar.concat.min.js"></script> <script> // Scrollbar var Scrollbar = function() { "use strict"; // Handle Scrollbar Linear var handleScrollbarLinear = function() { $(".scrollbar").mCustomScrollbar({ theme: "minimal-dark" }); } return { init: function() { handleScrollbarLinear(); // initial setup for scrollbar linear } } }(); $(document).ready(function() { Scrollbar.init(); }); /*========================== Stikcy Navbar ============================*/ window.onscroll = function() { myFunction() }; var navbar = document.getElementById("sticky-navbar"); var sticky = navbar.offsetTop; function myFunction() { if (window.pageYOffset >= sticky) { navbar.classList.add("sticky") } else { navbar.classList.remove("sticky"); } } /*========================== Bootstrap Popover ============================*/ $(function () { $('[data-toggle="popover"]').popover() }) </script>  <script src="/assets/js/jquery.malihu.PageScroll2id.min.js"></script> <script> (function($){ $(window).on("load",function(){ $("a[rel='m_PageScroll2id']").mPageScroll2id(); }); })(jQuery); </script>  <script type="text/javascript" src="/assets/js/jquery.matchHeight-min.js"></script> <script> $(function() { $('.match-height').matchHeight({ byRow: true, property: 'height', target: null, }); }); </script> <script type="text/javascript" src="/assets/js/grids.min.js"></script> <script type="text/javascript"> // Equal Height var EqualHeight = function() { "use strict"; // Handle Equal Height var handleEqualHeight = function() { $(function($) { $('.equal-height').responsiveEqualHeightGrid(); }); } return { init: function() { handleEqualHeight(); // initial setup for equal height } } }(); $(document).ready(function() { EqualHeight.init(); }); </script>  <script src="https://cdnjs.cloudflare.com/ajax/libs/bootstrap-select/1.13.2/js/bootstrap-select.min.js"></script> <script> $('.selectpicker').selectpicker(); </script> <script> $(document).ready(function(){ var filecount = 1; $('.filerowclass').each(function(){ var countattr = $(this).attr('countattr'); if(filecount == countattr){ var countlink = $('#rowfile'+countattr+ ' .filelinkclass').length; if(countlink == 0){ $('#rowfile'+countattr).remove(); } } filecount++; }); }); </script> <link href="https://cdn.jsdelivr.net/npm/select2@4.1.0-rc.0/dist/css/select2.min.css" rel="stylesheet" /> <script src="https://cdn.jsdelivr.net/npm/select2@4.1.0-rc.0/dist/js/select2.min.js"></script> </body> </html>