{"title":"Protein Secondary Structure Prediction","authors":"Manpreet Singh, Parvinder Singh Sandhu, Reet Kamal Kaur","volume":18,"journal":"International Journal of Bioengineering and Life Sciences","pagesStart":108,"pagesEnd":112,"ISSN":"1307-6892","URL":"https:\/\/publications.waset.org\/pdf\/14119","abstract":"Protein structure determination and prediction has\r\nbeen a focal research subject in the field of bioinformatics due to the\r\nimportance of protein structure in understanding the biological and\r\nchemical activities of organisms. The experimental methods used by\r\nbiotechnologists to determine the structures of proteins demand\r\nsophisticated equipment and time. A host of computational methods\r\nare developed to predict the location of secondary structure elements\r\nin proteins for complementing or creating insights into experimental\r\nresults. However, prediction accuracies of these methods rarely\r\nexceed 70%.","references":"[1] Cuff, J. A. and Barton, G.J. \"Evaluation and improvement of multiple\r\nsequence methods for protein secondary structure prediction. Proteins,\r\n34, 1999, pp. 508-519.\r\n[2] Cuff, J.A. and Barton G.J. \"Application of multiple sequence alignment\r\nprofiles to improve protein secondary structure prediction\" Proteins, 40,\r\n2000, pp. 502-511.\r\n[3] Jones, D.T. \"Protein secondary structure prediction based on positionspecific\r\nscoring matrices\" Journal of Molecular Biology, 292, 1999, pp.\r\n195 -202.\r\n[4] Kabsch, W. and Sander, C. \"Dictionary of protein secondary structure:\r\nPattern recognition of hydrogen-bonded and geometrical features\"\r\nBiopolymers, 22, 1983, pp. 2577-2637.\r\n[5] Kloczkowski, A., Ting, K.L., Jernigan, R.L. and Garnier, J. \"Combining\r\nthe GORV algorithm with evolutionary information for protein\r\nsecondary structure prediction from amino acid sequence\" Proteins, 49,\r\n2002, pp. 154-166.\r\n[6] Krane, D. and Raymer, M. (2003), \"Fundamental Concepts of\r\nBioinformatics\", Pearson Education, New Delhi, pp.1-314.\r\n[7] Moult, J., Hubbard, T., Bryant, S.H., Fidelis, K. and Pedersen, J.T.\r\n\"Critical assesment of methods of protein structure prediction (CASP):\r\nround II\". Proteins, S1, 1992, pp. 2-6.\r\n[8] Rost, B. and Sander, C. (1993) \"Prediction of protein secondary\r\nstructure at better than 70% accuracy\" Journal of Molecular Biology,\r\n232, pp. 584-599.\r\n[9] Sander, C. and Schneider, R. \"Database of homology-derived structures\r\nand the structural meaning of sequence alignment\" Proteins, 9, 1991, 56-\r\n68.","publisher":"World Academy of Science, Engineering and Technology","index":"Open Science Index 18, 2008"}