Search results for: Junie B. Billones

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Billones</title> <meta name="description" content="Search results for: Junie B. Billones"> <meta name="keywords" content="Junie B. Billones"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="Junie B. 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Billones"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 3</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Junie B. Billones</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Structure-Based Virtual Screening and in Silico Toxicity Test of Compounds against Mycobacterium tuberculosis 7,8-Diaminopelargonic Acid Aminotransferase (MtbBioA)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Junie%20B.%20Billones">Junie B. Billones</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Constancia%20O.%20Carrillo"> Maria Constancia O. Carrillo</a>, <a href="https://publications.waset.org/abstracts/search?q=Voltaire%20G.%20Organo"> Voltaire G. Organo</a>, <a href="https://publications.waset.org/abstracts/search?q=Stephani%20Joy%20Y.%20Macalino"> Stephani Joy Y. Macalino</a>, <a href="https://publications.waset.org/abstracts/search?q=Inno%20A.%20Emnacen"> Inno A. Emnacen</a>, <a href="https://publications.waset.org/abstracts/search?q=Jamie%20Bernadette%20A.%20Sy"> Jamie Bernadette A. Sy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> One of the major interferences in the Philippines’ tuberculosis control program is the widespread prevalence of Mtb strains that are resistant to known drugs, such as the MDR-TB (Multi Drug Resistant Tuberculosis) and XDR-TB (Extensively Drug Resistant Tuberculosis). Therefore, there is a pressing need to search for novel Mtb drug targets in order to be able to combat these drug resistant strains. The enzyme 7,8-diaminopelargonic acid aminotransferase enzyme, or more commonly known as BioA, is one such ideal target, as it is known that humans do not possess this enzyme. BioA primarily plays a key role in Mtb’s lipid biosynthesis pathway; more specifically in the synthesis of the enzyme cofactor biotin. In this study, structure-based pharmacophore screening, docking, and ADMET evaluation of compounds obtained from the DrugBank chemical database were performed against the MtbBioA enzyme. Results of the screening, docking, ADMET, and TOPKAT calculations revealed that out of the 6,516 compounds in the library, only 7 compounds indicated more favorable binding energies as compared to the enzyme’s known inhibitor, amiclenomycin (ACM), as well as good solubility and toxicity properties. Moreover, out of these 7 compounds, Molecule 6 exhibited the best solubility and toxicity properties. In the future, these lead compounds may then be subjected to bioactivity assays in vitro or in vivo for further evaluation of its therapeutic efficacy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=7" title="7">7</a>, <a href="https://publications.waset.org/abstracts/search?q=8-diaminopelargonic%20acid%20aminotransferase" title="8-diaminopelargonic acid aminotransferase">8-diaminopelargonic acid aminotransferase</a>, <a href="https://publications.waset.org/abstracts/search?q=BioA" title=" BioA"> BioA</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmacophore" title=" pharmacophore"> pharmacophore</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20docking" title=" molecular docking"> molecular docking</a>, <a href="https://publications.waset.org/abstracts/search?q=ADMET" title=" ADMET"> ADMET</a>, <a href="https://publications.waset.org/abstracts/search?q=TOPKAT" title=" TOPKAT"> TOPKAT</a> </p> <a href="https://publications.waset.org/abstracts/9299/structure-based-virtual-screening-and-in-silico-toxicity-test-of-compounds-against-mycobacterium-tuberculosis-78-diaminopelargonic-acid-aminotransferase-mtbbioa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9299.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">458</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Virtual Screening and in Silico Toxicity Property Prediction of Compounds against Mycobacterium tuberculosis Lipoate Protein Ligase B (LipB)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Junie%20B.%20Billones">Junie B. Billones</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Constancia%20O.%20Carrillo"> Maria Constancia O. Carrillo</a>, <a href="https://publications.waset.org/abstracts/search?q=Voltaire%20G.%20Organo"> Voltaire G. Organo</a>, <a href="https://publications.waset.org/abstracts/search?q=Stephani%20Joy%20Y.%20Macalino"> Stephani Joy Y. Macalino</a>, <a href="https://publications.waset.org/abstracts/search?q=Inno%20A.%20Emnacen"> Inno A. Emnacen</a>, <a href="https://publications.waset.org/abstracts/search?q=Jamie%20Bernadette%20A.%20Sy"> Jamie Bernadette A. Sy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The drug discovery and development process is generally known to be a very lengthy and labor-intensive process. Therefore, in order to be able to deliver prompt and effective responses to cure certain diseases, there is an urgent need to reduce the time and resources needed to design, develop, and optimize potential drugs. Computer-aided drug design (CADD) is able to alleviate this issue by applying computational power in order to streamline the whole drug discovery process, starting from target identification to lead optimization. This drug design approach can be predominantly applied to diseases that cause major public health concerns, such as tuberculosis. Hitherto, there has been no concrete cure for this disease, especially with the continuing emergence of drug resistant strains. In this study, CADD is employed for tuberculosis by first identifying a key enzyme in the mycobacterium’s metabolic pathway that would make a good drug target. One such potential target is the lipoate protein ligase B enzyme (LipB), which is a key enzyme in the M. tuberculosis metabolic pathway involved in the biosynthesis of the lipoic acid cofactor. Its expression is considerably up-regulated in patients with multi-drug resistant tuberculosis (MDR-TB) and it has no known back-up mechanism that can take over its function when inhibited, making it an extremely attractive target. Using cutting-edge computational methods, compounds from AnalytiCon Discovery Natural Derivatives database were screened and docked against the LipB enzyme in order to rank them based on their binding affinities. Compounds which have better binding affinities than LipB’s known inhibitor, decanoic acid, were subjected to in silico toxicity evaluation using the ADMET and TOPKAT protocols. Out of the 31,692 compounds in the database, 112 of these showed better binding energies than decanoic acid. Furthermore, 12 out of the 112 compounds showed highly promising ADMET and TOPKAT properties. Future studies involving in vitro or in vivo bioassays may be done to further confirm the therapeutic efficacy of these 12 compounds, which eventually may then lead to a novel class of anti-tuberculosis drugs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pharmacophore" title="pharmacophore">pharmacophore</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20docking" title=" molecular docking"> molecular docking</a>, <a href="https://publications.waset.org/abstracts/search?q=lipoate%20protein%20ligase%20B%20%28LipB%29" title=" lipoate protein ligase B (LipB)"> lipoate protein ligase B (LipB)</a>, <a href="https://publications.waset.org/abstracts/search?q=ADMET" title=" ADMET"> ADMET</a>, <a href="https://publications.waset.org/abstracts/search?q=TOPKAT" title=" TOPKAT"> TOPKAT</a> </p> <a href="https://publications.waset.org/abstracts/9951/virtual-screening-and-in-silico-toxicity-property-prediction-of-compounds-against-mycobacterium-tuberculosis-lipoate-protein-ligase-b-lipb" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9951.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">423</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Comparative Evaluation of the Effectiveness of Different Mindfulness-Based Interventions on Medically Unexplained Symptoms: A Systematic Review</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20R.%20Billones">R. R. Billones</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Lukkahatai"> N. Lukkahatai</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20N.%20Saligan"> L. N. Saligan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Mindfulness based interventions (MBIs) have been used in medically unexplained symptoms (MUS). This systematic review describes the literature investigating the general effect of MBIs on MUS and identifies the effects of specific MBIs on specific MUS conditions. The preferred reporting items for systematic reviews and meta-analysis guidelines (PRISMA) and the modified Oxford quality scoring system (JADAD) were applied to the review, yielding an initial 1,556 articles. The search engines included PubMed, ScienceDirect, Web of Science, Scopus, EMBASE, and PsychINFO using the search terms: mindfulness, or mediations, or mindful or MBCT or MBSR and medically unexplained symptoms or MUS or fibromyalgia or FMS. A total of 24 articles were included in the final systematic review. MBIs showed large effects on socialization skills for chronic fatigue syndrome (d=0.65), anger in fibromyalgia (d=0.61), improvement of somatic symptoms (d=1.6) and sleep (d=1.12) for painful conditions, physical health for chronic back pain (d=0.51), and disease intensity for irritable bowel disease/syndrome (d=1.13). A manualized MBI that applies the four fundamental elements present in all types of interventions were critical to efficacy. These elements were psycho-education sessions specific to better understand the medical symptoms, the practice of awareness, the non-judgmental observance of the experience at the moment, and the compassion to ones’ self. The effectiveness of different mindfulness interventions necessitates giving attention to improve the gaps that were identified related to home-based practice monitoring, competency training of mindfulness teachers, and sound psychometric properties to measure the mindfulness practice. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mindfulness-based%20interventions" title="mindfulness-based interventions">mindfulness-based interventions</a>, <a href="https://publications.waset.org/abstracts/search?q=medically%20unexplained%20symptoms" title=" medically unexplained symptoms"> medically unexplained symptoms</a>, <a href="https://publications.waset.org/abstracts/search?q=mindfulness-based%20cognitive%20therapy" title=" mindfulness-based cognitive therapy"> mindfulness-based cognitive therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=mindfulness-based%20stress%20reduction" title=" mindfulness-based stress reduction"> mindfulness-based stress reduction</a>, <a href="https://publications.waset.org/abstracts/search?q=fibromyalgia" title=" fibromyalgia"> fibromyalgia</a>, <a href="https://publications.waset.org/abstracts/search?q=irritable%20bowel%20syndrome" title=" irritable bowel syndrome"> irritable bowel syndrome</a> </p> <a href="https://publications.waset.org/abstracts/104060/comparative-evaluation-of-the-effectiveness-of-different-mindfulness-based-interventions-on-medically-unexplained-symptoms-a-systematic-review" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/104060.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">142</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div 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Search results for: Junie B. Billones