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class="elementor-heading-title elementor-size-default">Our research is supported by dedicated science & technology platforms:</h3> </div> </div> <div class="elementor-element elementor-element-4940f57 elementor-widget__width-initial elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="4940f57" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-88dee2e elementor-icon-list--layout-inline elementor-align-center elementor-list-item-link-inline elementor-mobile-align-left elementor-widget-mobile__width-auto elementor-widget elementor-widget-icon-list" data-id="88dee2e" data-element_type="widget" data-widget_type="icon-list.default"> <div class="elementor-widget-container"> <ul class="elementor-icon-list-items elementor-inline-items"> <li class="elementor-icon-list-item elementor-inline-item"> <a href="#small-molecules"> <span class="elementor-icon-list-icon"> <svg aria-hidden="true" class="e-font-icon-svg e-fas-circle" viewBox="0 0 512 512" xmlns="http://www.w3.org/2000/svg"><path d="M256 8C119 8 8 119 8 256s111 248 248 248 248-111 248-248S393 8 256 8z"></path></svg> </span> <span class="elementor-icon-list-text">Small Molecules </span> </a> </li> <li class="elementor-icon-list-item elementor-inline-item"> <a href="#adc-platform"> <span class="elementor-icon-list-icon"> <svg aria-hidden="true" class="e-font-icon-svg e-fas-circle" viewBox="0 0 512 512" xmlns="http://www.w3.org/2000/svg"><path d="M256 8C119 8 8 119 8 256s111 248 248 248 248-111 248-248S393 8 256 8z"></path></svg> </span> <span class="elementor-icon-list-text">ADC Platform </span> </a> </li> </ul> </div> </div> <div class="elementor-element elementor-element-b8150ef elementor-widget elementor-widget-heading" data-id="b8150ef" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Research Overview </h3> </div> </div> <div class="elementor-element elementor-element-b4731a4 elementor-widget elementor-widget-text-editor" data-id="b4731a4" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><span data-contrast="none">Research is the driving force of Nerviano Medical Sciences. With a long-standing expertise in R&D, we have a proven ability to conduct innovative research and advance molecules from discovery through clinical development to registration. Our work focuses on key biological targets and mechanisms that drive the onset and progression of cancer. By exploring novel pathways, identifying innovative drug targets, and developing both first- and best-in-class therapies, we aim to combat treatment resistance and improve patient outcomes.</span><span data-ccp-props="{"335557856":16777215}"> </span></p> </div> </div> <div class="elementor-element elementor-element-cd4cfe3 elementor-widget elementor-widget-heading" data-id="cd4cfe3" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Cell Cycle & DNA Repair</h3> </div> </div> <div class="elementor-element elementor-element-0f7f804 elementor-widget elementor-widget-text-editor" data-id="0f7f804" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Uncontrolled cell proliferation and defective DNA repair are hallmarks of cancer. By targeting key cell cycle proteins like CDKs, <a href="https://www.nervianoms.com/pipeline/"><span class="fabric-text-color-mark" data-renderer-mark="true" data-text-custom-color="#ff5630">PLK1</span></a>, and <a href="https://www.nervianoms.com/pipeline/"><span class="fabric-text-color-mark" data-renderer-mark="true" data-text-custom-color="#ff5630">MPS1</span></a>, and exploiting synthetic lethality in DNA repair pathways such as BRCA1/2 and <a href="https://www.nervianoms.com/pipeline/"><span class="fabric-text-color-mark" data-renderer-mark="true" data-text-custom-color="#ff5630">PARP</span></a>, we aim to inhibit cancer growth while preserving healthy cells.</p> </div> </div> <div class="elementor-element elementor-element-920dbf3 heading-anchor elementor-widget elementor-widget-heading" data-id="920dbf3" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Our second-generation non-trapping, brain penetrant <a href="/pipeline/#nms-293">PARP1 inhibitor </a>holds the potential to be first and best-in-class</h3> </div> </div> <div class="elementor-element elementor-element-ea64f42 elementor-widget__width-initial elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="ea64f42" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-3b54011 elementor-widget elementor-widget-heading" data-id="3b54011" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default"><br>Tumor Metabolism & Protein Homeostasis </h3> </div> </div> <div class="elementor-element elementor-element-b3b41f5 elementor-widget elementor-widget-text-editor" data-id="b3b41f5" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Cancer cells often rely on altered metabolism and protein regulation to sustain their growth and survive under stress. Our research focuses on identifying and targeting these vulnerabilities, such as the Unfolded Protein Response (UPR) and its key regulator <a href="https://www.nervianoms.com/pipeline/#nms-812">PERK</a> and <a href="https://www.nervianoms.com/pipeline/#nms-812">GCN2</a>, to induce cancer cell death through proteotoxicity, particularly in diseases like Multiple Myeloma and Acute Myeloid Leukemia.</p> </div> </div> <div class="elementor-element elementor-element-046f33d elementor-widget elementor-widget-heading" data-id="046f33d" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Immuno-Oncology </h3> </div> </div> <div class="elementor-element elementor-element-63f27e1 elementor-widget elementor-widget-text-editor" data-id="63f27e1" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><span data-contrast="none">While immunotherapy has revolutionized cancer treatment, we are exploring new ways to enhance immune responses against cancer. Our research focuses on discovering small molecules that either stimulate immune cells to attack tumors or make cancer cells more recognizable to the immune system. Small molecules offer unique advantages, including oral administration and the potential for combination with existing therapies to improve efficacy.</span><span data-ccp-props="{"335557856":16777215}"> </span></p> </div> </div> </div> </div> <div class="elementor-element elementor-element-d209def e-flex e-con-boxed e-con e-parent" data-id="d209def" data-element_type="container" id="small-molecules" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-b59baa8 elementor-widget elementor-widget-heading" data-id="b59baa8" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default"> Small Molecule Platform: </h2> </div> </div> <div class="elementor-element elementor-element-5397307 elementor-widget elementor-widget-text-editor" data-id="5397307" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Kinases are a crucial class of pharmaceutical targets, valued for their broad biological relevance and druggability by small molecules. <strong>As pioneers in recognizing the importance of Kinases for personalized anticancer therapies, Nerviano Medical Sciences has built a dedicated Kinase Platform.</strong> This specialized infrastructure integrates advanced chemistry and biology approaches to target various Kinase families.</p> </div> </div> <div class="elementor-element elementor-element-21bf337 e-con-full e-flex e-con e-child" data-id="21bf337" data-element_type="container"> <div class="elementor-element elementor-element-66eb735 elementor-widget elementor-widget-image" data-id="66eb735" data-element_type="widget" data-settings="{"motion_fx_motion_fx_scrolling":"yes","motion_fx_translateY_effect":"yes","motion_fx_translateY_speed":{"unit":"px","size":3,"sizes":[]},"motion_fx_translateY_affectedRange":{"unit":"%","size":"","sizes":{"start":0,"end":50}},"motion_fx_devices":["widescreen","desktop","laptop","tablet","mobile"]}" data-widget_type="image.default"> <div class="elementor-widget-container"> <picture fetchpriority="high" decoding="async" class="attachment-full size-full wp-image-4653"> <source type="image/webp" srcset="https://www.nervianoms.com/wp-content/uploads/2024/11/shutterstock_1665589090.png.webp 1920w, https://www.nervianoms.com/wp-content/uploads/2024/11/shutterstock_1665589090-300x200.png.webp 300w, https://www.nervianoms.com/wp-content/uploads/2024/11/shutterstock_1665589090-1024x682.png.webp 1024w, https://www.nervianoms.com/wp-content/uploads/2024/11/shutterstock_1665589090-768x512.png.webp 768w, https://www.nervianoms.com/wp-content/uploads/2024/11/shutterstock_1665589090-1536x1023.png.webp 1536w" sizes="(max-width: 1920px) 100vw, 1920px"/> <img fetchpriority="high" decoding="async" width="1920" height="1279" src="https://www.nervianoms.com/wp-content/uploads/2024/11/shutterstock_1665589090.png" alt="" srcset="https://www.nervianoms.com/wp-content/uploads/2024/11/shutterstock_1665589090.png 1920w, https://www.nervianoms.com/wp-content/uploads/2024/11/shutterstock_1665589090-300x200.png 300w, https://www.nervianoms.com/wp-content/uploads/2024/11/shutterstock_1665589090-1024x682.png 1024w, https://www.nervianoms.com/wp-content/uploads/2024/11/shutterstock_1665589090-768x512.png 768w, https://www.nervianoms.com/wp-content/uploads/2024/11/shutterstock_1665589090-1536x1023.png 1536w" sizes="(max-width: 1920px) 100vw, 1920px"/> </picture> </div> </div> </div> <div class="elementor-element elementor-element-1d44903 e-con-full e-flex e-con e-child" data-id="1d44903" data-element_type="container"> <div class="elementor-element elementor-element-10ef9d1 elementor-widget__width-inherit elementor-widget elementor-widget-text-editor" data-id="10ef9d1" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Our Kinase Platform has successfully delivered potent and selective inhibitors, several of which are either approved or in clinical development, reinforcing our commitment to advancing targeted cancer therapies.</p><p>We remain dedicated to leveraging our deep expertise in Kinases to advance and continuously expand our broad portfolio of preclinical and clinical Kinase inhibitor programs. Focused on the key areas of Oncology and Immuno-oncology, we are committed to driving innovation and developing next-generation therapies that address unmet medical needs.<a id="readMoreCobat1" href="#"></a></p> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-9c936ee hideContentCobat11 e-flex e-con-boxed e-con e-parent" data-id="9c936ee" data-element_type="container" data-settings="{"background_background":"classic","background_motion_fx_motion_fx_mouse":"yes"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-c5716cd elementor-widget elementor-widget-heading" data-id="c5716cd" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Kinase as drug targets </h3> </div> </div> <div class="elementor-element elementor-element-0a621dc elementor-widget elementor-widget-text-editor" data-id="0a621dc" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>Clinical Validation </strong><br />Kinases regulate key intracellular pathways that become dysregulated in cancer, often referred to as the “hallmarks of cancer.” Currently, there are over 40 kinase-targeted drugs approved for a wide variety of solid and hematological tumors, with an impressive number of additional molecules in clinical development.</p><p><strong>Unexplored Potential </strong><br />Despite significant progress in the development of Kinase inhibitors over the past two decades, the full therapeutic potential of Kinase inhibition has yet to be fully realized. As our understanding of the physiological and pathological roles of the 500+ Kinase enzymes expand, new opportunities unlock innovative therapeutic avenues.</p><p><strong>Medical Need and Emerging Role in Combination Therapies </strong><br />Kinase inhibitors exemplify the success of targeted therapies, offering prolonged and often remarkable responses in patients selected for specific targets. However, drug resistance remains a clinical challenge, driving the urgency for next-generation inhibitors designed to overcome resistance mechanisms. Furthermore, cutting-edge research into combination therapies, to unlock the potential to amplify and extend the efficacy of Kinase inhibitors, offers new hope for more durable and comprehensive treatment strategies.</p> </div> </div> <div class="elementor-element elementor-element-a04cf00 e-con-full e-flex e-con e-child" data-id="a04cf00" data-element_type="container"> <div class="elementor-element elementor-element-675abc4 elementor-widget elementor-widget-text-editor" data-id="675abc4" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>NMS Kinase Platform </strong><br />A robust infrastructure of expertise, intellectual property, and advanced tools dedicated to Kinases. With over 20 years of integrated chemistry and biology approaches, our platform drives the rapid development of potent, selective Kinase inhibitors. It leverages an economy of scale to ensure the continuous delivery of first-in-class or best-in-class molecules, driving innovation across different tumor settings while evolving with the latest scientific and technological advancements.</p> </div> </div> </div> <div class="elementor-element elementor-element-2476c53 e-con-full e-flex e-con e-child" data-id="2476c53" data-element_type="container"> <div class="elementor-element elementor-element-d5638e0 elementor-widget__width-inherit elementor-widget elementor-widget-image" data-id="d5638e0" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <a href="https://nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7.png" data-elementor-open-lightbox="yes" data-e-action-hash="#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MzAwNCwidXJsIjoiaHR0cHM6XC9cL3d3dy5uZXJ2aWFub21zLmNvbVwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMTBcL0tpbmFzZVBsYXRmb3JtR3JhcGhpY192Ny5wbmcifQ%3D%3D"> <picture decoding="async" class="attachment-full size-full wp-image-3004"> <source type="image/webp" srcset="https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7.png.webp 2083w, https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7-300x300.png.webp 300w, https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7-1024x1024.png.webp 1024w, https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7-150x150.png.webp 150w, https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7-768x768.png.webp 768w, https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7-1536x1536.png.webp 1536w, https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7-2048x2048.png.webp 2048w" sizes="(max-width: 2083px) 100vw, 2083px"/> <img decoding="async" width="2083" height="2083" src="https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7.png" alt="" srcset="https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7.png 2083w, https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7-300x300.png 300w, https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7-1024x1024.png 1024w, https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7-150x150.png 150w, https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7-768x768.png 768w, https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7-1536x1536.png 1536w, https://www.nervianoms.com/wp-content/uploads/2024/10/KinasePlatformGraphic_v7-2048x2048.png 2048w" sizes="(max-width: 2083px) 100vw, 2083px"/> </picture> </a> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-49c12b1 e-flex e-con-boxed e-con e-parent" data-id="49c12b1" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-6763d4c elementor-widget elementor-widget-html" data-id="6763d4c" data-element_type="widget" data-widget_type="html.default"> <div class="elementor-widget-container"> <br><a id="readMoreCobat11" class="show-more">+ Show More </a> </div> </div> </div> </div> <div class="elementor-element elementor-element-5a8c942 cells-right e-flex e-con-boxed e-con e-parent" data-id="5a8c942" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-524176d elementor-widget elementor-widget-heading" data-id="524176d" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Target identification and validation </h3> </div> </div> <div class="elementor-element elementor-element-a35f224 elementor-widget elementor-widget-text-editor" data-id="a35f224" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>Target Identification and Validation </strong><br />We apply integrated genomics and proteomics profiling of cancer cell lines and tumor samples to uncover dysregulated networks and identify potential new therapeutic targets. <strong>Using advanced bioinformatics, including proprietary in-house tools, we mine both internal and external databases to pinpoint new genomic alterations involving Kinases in specific tumor contexts.</strong> Our large-scale gene silencing and phenotypic screenings across molecularly characterized cancer cell panels help identify synthetic lethality contexts and novel targets in select genetic backgrounds. These approaches have led to the discovery of several new targets at NMS, with promising first-in-class programs underway.</p> </div> </div> <div class="elementor-element elementor-element-bba45f1 elementor-widget elementor-widget-heading" data-id="bba45f1" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Kinase Targeted Libraries (KTL)</h3> </div> </div> <div class="elementor-element elementor-element-f7c2f77 elementor-widget elementor-widget-text-editor" data-id="f7c2f77" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> Our Kinase Targeted Library (KTL) is a proprietary collection of approximately 100,000 molecules, specifically designed to interact with Kinases. Synthesized entirely in-house, the library spans over 100 diverse chemical classes, offering broad coverage of the Kinase inhibitor chemical space. It serves as an ideal starting point for hit identification and structure-activity relationship (SAR) studies. The KTL is continuously expanded through crystallography and modeling approaches, which also enhance hit affinity and selectivity for specific targets. The KTL, along with an extended library for other purine-binding enzymes (PTL), provides a robust resource for hit discovery, with extensive patent protection and strong intellectual property positions. </div> </div> <div class="elementor-element elementor-element-0d55117 elementor-widget elementor-widget-text-editor" data-id="0d55117" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>KINASE Selectivity Screening (KSS) </strong><br />Our Kinase Selectivity Screening (KSS) platform consists of a panel of over 100 automated biochemical Kinase assays, developed in-house at NMS. These assays evaluate the selectivity profiles of compounds and expand our knowledge of chemical interactions across different Kinases. KSS is instrumental in supporting Structure-Based Drug Design (SBDD) for Kinase inhibitors.</p><p>The enzyme proteins used in these screenings are entirely produced and characterized in-house, allowing for robust potency assessments (IC50) that are directly comparable across various targets. The panel is constantly updated with new, unexplored Kinase targets, providing opportunities for the discovery of new hits and leads across our diverse Kinase projects.</p><p>Our Kinase Selectivity Screening (KSS) platform consists of a panel of over 100 automated biochemical Kinase assays, developed in-house at NMS. These assays evaluate the selectivity profiles of compounds and expand our knowledge of chemical interactions across different Kinases. Over time, KSS has supported the discovery of more than 14,000 hits, providing critical insights that drive Structure-Based Drug Design (SBDD) for Kinase inhibitors.</p><p>The enzyme proteins used in these screenings are entirely produced and characterized in-house, allowing for robust potency assessments (IC50) that are directly comparable across various targets. The panel is constantly updated with new, unexplored Kinase targets, providing opportunities for the discovery of new hits and leads across our diverse Kinase projects.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-096d4b0 e-flex e-con-boxed e-con e-parent" data-id="096d4b0" data-element_type="container" id="adc-platform" data-settings="{"background_background":"gradient"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-e156e8b elementor-widget__width-inherit elementor-widget elementor-widget-heading" data-id="e156e8b" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">ADC Platform </h2> </div> </div> <div class="elementor-element elementor-element-4bad779 elementor-widget__width-inherit elementor-widget elementor-widget-heading" data-id="4bad779" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">NMS ADC integrated platform of payload linkers </h3> </div> </div> <div class="elementor-element elementor-element-ad2238a elementor-widget elementor-widget-text-editor" data-id="ad2238a" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Antibody-Drug Conjugates (ADCs) are groundbreaking in the realm of targeted cancer therapy, marrying the specificity of monoclonal antibodies (mAbs) with the potent killing power of cytotoxic drugs. Their design leverages the precision of antibody targeting to deliver cytotoxic agents directly to cancer cells, thereby sparing normal, healthy cells from the toxic effects of chemotherapy. This approach enhances the efficacy of the drug and minimizes side effects, offering a promising treatment option for various types of cancer.</p> </div> </div> <div class="elementor-element elementor-element-9389ce8 e-con-full e-flex e-con e-child" data-id="9389ce8" data-element_type="container"> <div class="elementor-element elementor-element-b6e57ec elementor-widget elementor-widget-text-editor" data-id="b6e57ec" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>ADCs are a highly sophisticated pharmaceutical, made of three main components:</p><ul><li><strong>Monoclonal antibody (mAb)</strong> – targets specific tumor antigens.</li><li><strong>Linker</strong> – connects the mAb to the cytotoxic drug.</li><li><strong>Payload</strong> – cytotoxic drug delivered specifically to cancer cells.</li></ul><p> </p> </div> </div> </div> <div class="elementor-element elementor-element-8b20c30 e-con-full e-flex e-con e-child" data-id="8b20c30" data-element_type="container"> <div class="elementor-element elementor-element-4642fc7 elementor-widget__width-inherit elementor-widget elementor-widget-image" data-id="4642fc7" data-element_type="widget" data-settings="{"_animation":"none"}" data-widget_type="image.default"> <div class="elementor-widget-container"> <a href="https://www.nervianoms.com/wp-content/uploads/2024/11/ADCgraphic.jpg" data-elementor-open-lightbox="yes" data-e-action-hash="#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDY0MCwidXJsIjoiaHR0cHM6XC9cL3d3dy5uZXJ2aWFub21zLmNvbVwvd3AtY29udGVudFwvdXBsb2Fkc1wvMjAyNFwvMTFcL0FEQ2dyYXBoaWMuanBnIn0%3D"> <picture decoding="async" class="attachment-full size-full wp-image-4640"> <source type="image/webp" srcset="https://www.nervianoms.com/wp-content/uploads/2024/11/ADCgraphic.jpg.webp 1920w, https://www.nervianoms.com/wp-content/uploads/2024/11/ADCgraphic-300x169.jpg.webp 300w, https://www.nervianoms.com/wp-content/uploads/2024/11/ADCgraphic-1024x576.jpg.webp 1024w, https://www.nervianoms.com/wp-content/uploads/2024/11/ADCgraphic-768x432.jpg.webp 768w, https://www.nervianoms.com/wp-content/uploads/2024/11/ADCgraphic-1536x864.jpg.webp 1536w" sizes="(max-width: 1920px) 100vw, 1920px"/> <img decoding="async" width="1920" height="1080" src="https://www.nervianoms.com/wp-content/uploads/2024/11/ADCgraphic.jpg" alt="" srcset="https://www.nervianoms.com/wp-content/uploads/2024/11/ADCgraphic.jpg 1920w, https://www.nervianoms.com/wp-content/uploads/2024/11/ADCgraphic-300x169.jpg 300w, https://www.nervianoms.com/wp-content/uploads/2024/11/ADCgraphic-1024x576.jpg 1024w, https://www.nervianoms.com/wp-content/uploads/2024/11/ADCgraphic-768x432.jpg 768w, https://www.nervianoms.com/wp-content/uploads/2024/11/ADCgraphic-1536x864.jpg 1536w" sizes="(max-width: 1920px) 100vw, 1920px"/> </picture> </a> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-c08345a hideContentCobat12 e-flex e-con-boxed e-con e-parent" data-id="c08345a" data-element_type="container" data-settings="{"background_background":"classic"}"> <div class="e-con-inner"> <div class="elementor-element elementor-element-603635d elementor-widget elementor-widget-text-editor" data-id="603635d" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Combining the specificity of antibodies with the lethal potency of cytotoxic drugs paves the way for more effective and less toxic cancer therapies. The innovative design of ADCs represents a significant advancement in oncology, offering hope for more effective treatments with fewer side effects.</p><p>NMS is at the forefront of developing these cutting-edge therapies, contributing to the future of cancer treatment.</p> </div> </div> <div class="elementor-element elementor-element-6a1d006 elementor-widget elementor-widget-heading" data-id="6a1d006" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">Nerviano Medical Sciences’ edge in ADC technology: integrating key research expertise to create next-generation ADCs</h3> </div> </div> <div class="elementor-element elementor-element-c23b089 elementor-widget elementor-widget-text-editor" data-id="c23b089" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Developing fully functional ADCs is a sophisticated process that necessitates a multidisciplinary approach, integrating insights and techniques from molecular biology, chemistry, pharmacology, and bioengineering. NMS, with decades of expertise, innovates and integrates the various components and processes involved in ADC development to address emerging limitations in the field, including chemoresistance and limited therapeutic window.</p><p>NMS portfolio includes optimized duocarmycin (NMS-P945), anthracycline, and targeted payloads tailored to effectively treat diverse tumors with enhanced specificity. Utilizing a rigorous screening process, and a multifunctional approach to target selection, NMS delivers unparalleled ADC development opportunities with enhanced efficacy and safety. <a href="https://nervianoms.com/pipeline/">See our pipeline</a>.</p> </div> </div> <div class="elementor-element elementor-element-5582c30 elementor-position-left elementor-widget__width-inherit animated-slow elementor-view-default elementor-mobile-position-top elementor-vertical-align-top elementor-invisible elementor-widget elementor-widget-icon-box" data-id="5582c30" data-element_type="widget" data-settings="{"_animation":"fadeInUp"}" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div class="elementor-icon-box-icon"> <span class="elementor-icon elementor-animation-"> <svg xmlns="http://www.w3.org/2000/svg" width="425" height="635" viewBox="0 0 425 635"><g id="hands-holding-heart-svgrepo-com" transform="translate(350.553 448)"><rect 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Proprietary chemical collection </span> </h3> <p class="elementor-icon-box-description"> <br><ul><li>1000+ granted patents/applications</li> <li>310+ published papers since 2004</li> <li>100k +compounds cytotoxic and targeted agents</li> <li>20k+ compounds profiled in cells</li> <li>Available safety and efficacy studies</li> </ul> </p> </div> </div> </div> </div> <div class="elementor-element elementor-element-96ba931 elementor-position-left animated-slow elementor-view-default elementor-mobile-position-top elementor-vertical-align-top elementor-invisible elementor-widget elementor-widget-icon-box" data-id="96ba931" data-element_type="widget" data-settings="{"_animation":"fadeInUp"}" data-widget_type="icon-box.default"> <div class="elementor-widget-container"> <div class="elementor-icon-box-wrapper"> <div class="elementor-icon-box-icon"> <span class="elementor-icon elementor-animation-"> <svg xmlns="http://www.w3.org/2000/svg" width="529" height="529" viewBox="0 0 529 529"><g 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release.<\/p>","hotspot_offset_x":{"unit":"%","size":57.3,"sizes":[]},"_id":"9475fab","hotspot_label":"","hotspot_link":{"url":"","is_external":"","nofollow":"","custom_attributes":""},"hotspot_icon":{"value":"","library":""},"hotspot_horizontal":"left","hotspot_vertical":"top","hotspot_tooltip_position":"no","hotspot_position":null,"hotspot_position_widescreen":null,"hotspot_position_laptop":null,"hotspot_position_tablet":null,"hotspot_position_mobile":null,"hotspot_icon_position":null,"hotspot_icon_spacing":null,"hotspot_offset_x_widescreen":{"unit":"px","size":"","sizes":[]},"hotspot_offset_x_laptop":{"unit":"px","size":"","sizes":[]},"hotspot_offset_x_tablet":{"unit":"px","size":"","sizes":[]},"hotspot_offset_x_mobile":{"unit":"px","size":"","sizes":[]},"hotspot_offset_y":{"unit":"%","size":50,"sizes":[]},"hotspot_offset_y_widescreen":{"unit":"px","size":"","sizes":[]},"hotspot_offset_y_laptop":{"unit":"px","size":"","sizes":[]},"hotspot_offset_y_tablet":{"unit":"px","size":"","sizes":[]},"hotspot_offset_y_mobile":{"unit":"px","size":"","sizes":[]},"hotspot_tooltip_width":null,"hotspot_tooltip_width_widescreen":null,"hotspot_tooltip_width_laptop":null,"hotspot_tooltip_width_tablet":null,"hotspot_tooltip_width_mobile":null,"hotspot_tooltip_text_wrap":null},{"hotspot_custom_size":"","hotspot_width":null,"hotspot_height":null,"hotspot_tooltip_content":"<p><strong>ADC Generation<\/strong><br \/>Developing and prioritizing ADCs involves a rigorous evaluation of multiple critical parameters including Drug Antibody Ratio (DAR), aggregation, binding, antiproliferative activity in target (+) and target (-) cells, bystander effect, immunogenic cell death and plasma stability.<\/p>","hotspot_offset_x":{"unit":"%","size":6.3,"sizes":[]},"hotspot_offset_x_widescreen":{"unit":"px","size":6.6,"sizes":[]},"hotspot_offset_y":{"unit":"%","size":68.2,"sizes":[]},"hotspot_offset_y_widescreen":{"unit":"px","size":68.1,"sizes":[]},"_id":"13d17c9","hotspot_label":"","hotspot_link":{"url":"","is_external":"","nofollow":"","custom_attributes":""},"hotspot_icon":{"value":"","library":""},"hotspot_horizontal":"left","hotspot_vertical":"top","hotspot_tooltip_position":"no","hotspot_position":null,"hotspot_position_widescreen":null,"hotspot_position_laptop":null,"hotspot_position_tablet":null,"hotspot_position_mobile":null,"hotspot_icon_position":null,"hotspot_icon_spacing":null,"hotspot_offset_x_laptop":{"unit":"px","size":"","sizes":[]},"hotspot_offset_x_tablet":{"unit":"px","size":"","sizes":[]},"hotspot_offset_x_mobile":{"unit":"px","size":"","sizes":[]},"hotspot_offset_y_laptop":{"unit":"px","size":"","sizes":[]},"hotspot_offset_y_tablet":{"unit":"px","size":"","sizes":[]},"hotspot_offset_y_mobile":{"unit":"px","size":"","sizes":[]},"hotspot_tooltip_width":null,"hotspot_tooltip_width_widescreen":null,"hotspot_tooltip_width_laptop":null,"hotspot_tooltip_width_tablet":null,"hotspot_tooltip_width_mobile":null,"hotspot_tooltip_text_wrap":null},{"hotspot_custom_size":"","hotspot_width":null,"hotspot_height":null,"hotspot_tooltip_content":"<p><strong>ADC Preclinical Validation<\/strong><br \/>The process involves extensive testing in both in vitro and in vivo models to assess key aspects of preclinical validation such as efficacy in CDX and PDX models, and pharmacokinetic properties.<\/p>","hotspot_offset_x":{"unit":"%","size":35.6,"sizes":[]},"hotspot_offset_x_widescreen":{"unit":"px","size":35.7,"sizes":[]},"hotspot_offset_y":{"unit":"%","size":79.5,"sizes":[]},"hotspot_offset_y_widescreen":{"unit":"px","size":79.2,"sizes":[]},"_id":"9ddd81c","hotspot_label":"","hotspot_link":{"url":"","is_external":"","nofollow":"","custom_attributes":""},"hotspot_icon":{"value":"","library":""},"hotspot_horizontal":"left","hotspot_vertical":"top","hotspot_tooltip_position":"no","hotspot_position":null,"hotspot_position_widescreen":null,"hotspot_position_laptop":null,"hotspot_position_tablet":null,"hotspot_position_mobile":null,"hotspot_icon_position":null,"hotspot_icon_spacing":null,"hotspot_offset_x_laptop":{"unit":"px","size":"","sizes":[]},"hotspot_offset_x_tablet":{"unit":"px","size":"","sizes":[]},"hotspot_offset_x_mobile":{"unit":"px","size":"","sizes":[]},"hotspot_offset_y_laptop":{"unit":"px","size":"","sizes":[]},"hotspot_offset_y_tablet":{"unit":"px","size":"","sizes":[]},"hotspot_offset_y_mobile":{"unit":"px","size":"","sizes":[]},"hotspot_tooltip_width":null,"hotspot_tooltip_width_widescreen":null,"hotspot_tooltip_width_laptop":null,"hotspot_tooltip_width_tablet":null,"hotspot_tooltip_width_mobile":null,"hotspot_tooltip_text_wrap":null}],"hotspot_sequenced_animation":"yes","hotspot_sequenced_animation_duration":{"unit":"px","size":500,"sizes":[]},"tooltip_position":"bottom","tooltip_trigger":"mouseenter","tooltip_animation":"e-hotspot--fade-in-out"}" data-widget_type="hotspot.default"> <div class="elementor-widget-container"> <picture loading="lazy" decoding="async" class="attachment-full size-full wp-image-3973"> <source type="image/webp" srcset="https://www.nervianoms.com/wp-content/uploads/2024/11/PathGraphic_NM36_v1-1.jpg.webp 2000w, https://www.nervianoms.com/wp-content/uploads/2024/11/PathGraphic_NM36_v1-1-300x194.jpg.webp 300w, https://www.nervianoms.com/wp-content/uploads/2024/11/PathGraphic_NM36_v1-1-1024x661.jpg.webp 1024w, https://www.nervianoms.com/wp-content/uploads/2024/11/PathGraphic_NM36_v1-1-768x496.jpg.webp 768w, https://www.nervianoms.com/wp-content/uploads/2024/11/PathGraphic_NM36_v1-1-1536x991.jpg.webp 1536w" sizes="(max-width: 2000px) 100vw, 2000px"/> <img loading="lazy" decoding="async" width="2000" height="1291" src="https://www.nervianoms.com/wp-content/uploads/2024/11/PathGraphic_NM36_v1-1.jpg" alt="" srcset="https://www.nervianoms.com/wp-content/uploads/2024/11/PathGraphic_NM36_v1-1.jpg 2000w, https://www.nervianoms.com/wp-content/uploads/2024/11/PathGraphic_NM36_v1-1-300x194.jpg 300w, https://www.nervianoms.com/wp-content/uploads/2024/11/PathGraphic_NM36_v1-1-1024x661.jpg 1024w, https://www.nervianoms.com/wp-content/uploads/2024/11/PathGraphic_NM36_v1-1-768x496.jpg 768w, https://www.nervianoms.com/wp-content/uploads/2024/11/PathGraphic_NM36_v1-1-1536x991.jpg 1536w" sizes="(max-width: 2000px) 100vw, 2000px"/> </picture> <div class="e-hotspot elementor-repeater-item-6cb8ab2 e-hotspot--sequenced e-hotspot--position-left e-hotspot--position-top e-hotspot--circle"> <div class="e-hotspot__button e-hotspot--expand"> <div class="e-hotspot__outer-circle"></div> <div class="e-hotspot__inner-circle"></div> </div> <div class="e-hotspot__tooltip e-hotspot--tooltip-position e-hotspot--fade-in-out " > <p><strong>Target Identification<br /></strong>Starting from payload(s) features, a multidimensional approach including tumor sensitivity, medical need and competition drives the selection of the best suited target(s) for each payload-linker.</p> </div> </div> <div class="e-hotspot elementor-repeater-item-55b47a7 e-hotspot--sequenced e-hotspot--position-left e-hotspot--position-top e-hotspot--circle"> <div class="e-hotspot__button e-hotspot--expand"> <div class="e-hotspot__outer-circle"></div> <div class="e-hotspot__inner-circle"></div> </div> <div class="e-hotspot__tooltip e-hotspot--tooltip-position e-hotspot--fade-in-out " > <p><strong>Payload Identification<br /></strong>Starting from proprietary historical data and chemical collections, payloads are prioritized based on proliferation, safety and efficacy data, together with chemical feasibility and diversity.</p> </div> </div> <div class="e-hotspot elementor-repeater-item-9475fab e-hotspot--sequenced e-hotspot--position-left e-hotspot--position-top e-hotspot--circle"> <div class="e-hotspot__button e-hotspot--expand"> <div class="e-hotspot__outer-circle"></div> <div class="e-hotspot__inner-circle"></div> </div> <div class="e-hotspot__tooltip e-hotspot--tooltip-position e-hotspot--fade-in-out " > <p><strong>Payload Linker Generation</strong><br />Payloads prepared with different linkers are prioritized based on chemical stability and payload release.</p> </div> </div> <div class="e-hotspot elementor-repeater-item-13d17c9 e-hotspot--sequenced e-hotspot--position-left e-hotspot--position-top e-hotspot--circle"> <div class="e-hotspot__button e-hotspot--expand"> <div class="e-hotspot__outer-circle"></div> <div class="e-hotspot__inner-circle"></div> </div> <div class="e-hotspot__tooltip e-hotspot--tooltip-position e-hotspot--fade-in-out " > <p><strong>ADC Generation</strong><br />Developing and prioritizing ADCs involves a rigorous evaluation of multiple critical parameters including Drug Antibody Ratio (DAR), aggregation, binding, antiproliferative activity in target (+) and target (-) cells, bystander effect, immunogenic cell death and plasma stability.</p> </div> </div> <div class="e-hotspot elementor-repeater-item-9ddd81c e-hotspot--sequenced e-hotspot--position-left e-hotspot--position-top e-hotspot--circle"> <div class="e-hotspot__button e-hotspot--expand"> <div class="e-hotspot__outer-circle"></div> <div class="e-hotspot__inner-circle"></div> </div> <div class="e-hotspot__tooltip e-hotspot--tooltip-position e-hotspot--fade-in-out " > <p><strong>ADC Preclinical Validation</strong><br />The process involves extensive testing in both in vitro and in vivo models to assess key aspects of preclinical validation such as efficacy in CDX and PDX models, and pharmacokinetic properties.</p> </div> </div> </div> </div> <div class="elementor-element elementor-element-773b94c elementor-widget elementor-widget-text-editor" data-id="773b94c" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>Target Identification<br /></strong>Starting from payload(s) features, a multidimensional approach including tumor sensitivity, medical need and competition drives the selection of the best suited target(s) for each payload-linker.</p><p><strong>Payload Identification</strong><br />Starting from proprietary historical data and chemical collections, payloads are prioritized based on proliferation, safety and efficacy data, together with chemical feasibility and diversity.</p><p><strong>Payload Linker Generation</strong><br />Payloads prepared with different linkers are prioritized based on chemical stability and payload release.</p><p><strong>ADC Generation</strong><br />Developing and prioritizing ADCs involves a rigorous evaluation of multiple critical parameters including Drug Antibody Ratio (DAR), aggregation, binding, antiproliferative activity in target (+) and target (-) cells, bystander effect, immunogenic cell death and plasma stability.</p><p><strong>ADC Preclinical Validation</strong><br />The process involves extensive testing in both in vitro and in vivo models to assess key aspects of preclinical validation such as efficacy in CDX and PDX models, and pharmacokinetic properties.</p> </div> </div> </div> <div class="elementor-element elementor-element-565f216 elementor-widget elementor-widget-heading" data-id="565f216" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h3 class="elementor-heading-title elementor-size-default">NMS’s portfolio of payload linkers: expanding the ADC landscape enhancing the effectiveness and precision of cancer treatment </h3> </div> </div> <div class="elementor-element elementor-element-b3062f7 e-con-full e-flex e-con e-child" data-id="b3062f7" data-element_type="container"> <div class="elementor-element elementor-element-1d5abb2 elementor-widget__width-inherit animated-slow elementor-invisible elementor-widget elementor-widget-image" data-id="1d5abb2" data-element_type="widget" data-settings="{"_animation":"zoomIn"}" data-widget_type="image.default"> <div class="elementor-widget-container"> <picture loading="lazy" decoding="async" class="attachment-full size-full wp-image-2340"> <source type="image/webp" srcset="https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4.png.webp 2500w, https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4-300x300.png.webp 300w, https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4-1024x1024.png.webp 1024w, https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4-150x150.png.webp 150w, https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4-768x768.png.webp 768w, https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4-1536x1536.png.webp 1536w, https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4-2048x2048.png.webp 2048w" sizes="(max-width: 2500px) 100vw, 2500px"/> <img loading="lazy" decoding="async" width="2500" height="2500" src="https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4.png" alt="" srcset="https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4.png 2500w, https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4-300x300.png 300w, https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4-1024x1024.png 1024w, https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4-150x150.png 150w, https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4-768x768.png 768w, https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4-1536x1536.png 1536w, https://www.nervianoms.com/wp-content/uploads/2024/10/NMSPortfolioGraphic_v4-2048x2048.png 2048w" sizes="(max-width: 2500px) 100vw, 2500px"/> </picture> </div> </div> </div> <div class="elementor-element elementor-element-93e00a0 e-con-full e-flex e-con e-child" data-id="93e00a0" data-element_type="container"> <div class="elementor-element elementor-element-22215ef elementor-widget elementor-widget-text-editor" data-id="22215ef" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>NMS established a unique platform of cytotoxic and targeted payload linkers with peculiar features to develop the best ADC for any given target or tumor type:</p><p><strong>NMS-P945</strong> is a duocarmycin-based payload linker, acting as a DNA damaging agent and demonstrating strong bystander effect, high in vivo efficacy with cured mice and good safety profile suitable for chemo resistant highly heterogeneous solid tumors (<a href="https://aacrjournals.org/mct/article-abstract/22/12/1465/730263/Novel-Thienoduocarmycin-Trastuzumab-ADC?redirectedFrom=fulltext" target="_blank" rel="noopener">Mol Cancer Ther (2023) 22 (12): 1465–1478</a>).</p><p><strong>Next generation anthracyclines</strong> are topoisomerase II inhibitors showing outstanding immunogenic cell death properties, superior efficacy and safety profile to PNU payload suitable to revert cold into hot tumors (<a href="https://form.jotform.com/241192707868365" target="_blank" rel="noopener">AACR2024</a> , <a href="https://form.jotform.com/242104372260343" target="_blank" rel="noopener">NMCS_ACS2024</a> posters).</p> </div> </div> </div> <div class="elementor-element elementor-element-192e13c e-con-full e-flex e-con e-child" data-id="192e13c" data-element_type="container"> <div class="elementor-element elementor-element-8448c59 elementor-widget elementor-widget-text-editor" data-id="8448c59" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p data-ccp-border-top="0px none " data-ccp-padding-top="0px"><b><span data-contrast="auto">Novel targeted payloads</span></b><span data-contrast="auto"> with diversified mechanisms of action and to be developed with selected targeted antibodies to reach a unique selectivity and increased safety profile compared with current ADCs </span><i><span data-contrast="auto">(<a href="https://form.jotform.com/242104189352351" target="_blank" rel="noopener">WADC-EU 2024 </a></span></i><i><span data-contrast="auto">poster)</span></i><span data-ccp-props="{"335559739":560,"335572079":0,"335572080":12,"335572081":4278190080,"469789806":"none"}">.</span></p><p><b><span data-contrast="auto">Target-Payload matching</span></b><span data-contrast="auto"> via a multidimensional approach based on individual payload(s) features, tumor settings and market perspectives. Potential for increased selectivity and greater therapeutic window in patients.</span><span data-ccp-props="{"335559739":560}"> </span></p><p data-ccp-border-bottom="0px none #000000" data-ccp-padding-bottom="14.666666666666668px"><b><span data-contrast="none">See the poster presented at:</span></b><span data-ccp-props="{"335557856":16777215,"335572079":0,"335572080":11,"335572081":4278190080,"469789806":"none"}"> </span></p><p data-ccp-border-top="0px none " data-ccp-padding-top="0px" data-ccp-border-bottom="0px none #000000" data-ccp-padding-bottom="14.666666666666668px"><span data-contrast="auto">– </span><a href="https://form.jotform.com/241192707868365" target="_blank" rel="noopener">AACR 2024</a><a href="https://form.jotform.com/241192707868365"> </a> “<span data-contrast="auto">A novel platform of diversified cytotoxins and targeted payloads to drive ADC innovation”</span><span data-ccp-props="{"335557856":16777215,"335572079":0,"335572080":11,"335572081":4278190080,"469789806":"none"}"> </span></p><p data-ccp-border-top="0px none " data-ccp-padding-top="0px" data-ccp-border-bottom="0px none #000000" data-ccp-padding-bottom="14.666666666666668px"><span data-contrast="auto">– </span><a href="https://form.jotform.com/242104372260343" target="_blank" rel="noopener">ACS 2024 </a><span data-contrast="auto">“Development of 14-amino-anthracyclines as novel payloads for ADC production showing potent anti-tumor activity and improved safety profile”</span><span data-ccp-props="{"335557856":16777215,"335572079":0,"335572080":11,"335572081":4278190080,"469789806":"none"}"> </span></p><p data-ccp-border-top="0px none " data-ccp-padding-top="0px"><span data-contrast="auto">– </span><a href="https://form.jotform.com/242104189352351" target="_blank" rel="noopener">WADC Europe 2024</a><span data-contrast="auto"> “A payload-linker generating machine to quickly move from small molecules to characterized tool ADCs and PDCs”</span><span data-ccp-props="{"335557856":16777215,"335572079":0,"335572080":11,"335572081":4278190080,"469789806":"none"}"> </span></p><p>– WADC San Diego 2024</p><ul><li><a href="https://form.jotform.com/243182775979374" target="_blank" rel="noopener">Poster</a> “NMS ADCs platform: innovation by design”</li><li><a href="https://form.jotform.com/243224198060351" target="_blank" rel="noopener">Presentation by Barbara Valsasina</a> “Showcasing NMS’s Portfolio of Cytotoxins & Targeted Payloads to Drive ADC Innovation”</li></ul> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-05a9c0f e-flex e-con-boxed e-con e-parent" data-id="05a9c0f" data-element_type="container"> <div class="e-con-inner"> <div class="elementor-element elementor-element-0050373 elementor-widget elementor-widget-html" data-id="0050373" data-element_type="widget" data-widget_type="html.default"> <div class="elementor-widget-container"> <a 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