PDB-101: Learn: Flyers, Posters, & Calendars: Posters: How Do Drugs Work?

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Viruses</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/learn/exploring-the-structural-biology-of-health-and-nutrition";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Exploring the Structural Biology of Health and Nutrition</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/learn/exploring-the-structural-biology-of-evolution";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Exploring the Structural Biology of Evolution</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/learn/exploring-structural-biology-with-computed-structure-models-csms";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Exploring Structural Biology with Computed Structure Models (CSMs)</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/learn/resources-to-fight-the-covid-19-pandemic";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">COVID-19 Pandemic Resources</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> <div onclick="location.href="/learn/other-resources";" class="pdb101-left-menu-item"> <div class="pdb101-left-menu-item-text">Other Resources</div> <div class="pdb101-left-menu-item-chevron"><span class="fa fa-chevron-right fade"></span></div> </div> </div> </div> <div data-elastic-include class="col-sm-12 col-md-9 pdb101-page-content"> <div><h1>How do Drugs Work?</h1> <p>Proteins are tiny molecular machines that perform most of the tasks needed to keep cells alive. These machines are far too small to see, so you might imagine that it is impossible to affect their action. However, drugs can be used to turn proteins on or off.</p> <p>Drugs are small molecules that bind to one specific protein and modify its action. Some very powerful drugs, such as antibiotics or anticancer drugs, are used to completely disable a critical molecular machine. These drugs can kill a bacterial or cancer cell. Other molecules, such as aspirin, gently block less-critical proteins for a few hours. With the use of these drugs, we can make changes inside our own cells, such as the blocking of pain signals. Many structures of drugs that bind to proteins have been determined by scientists. These atomic structures allow us to see how drugs work, and perhaps how to modify them to improve their action. A few examples are shown here. Some of these drugs, like penicillin, were discovered in nature. Other drugs, such as HIV protease inhibitors, were created by using the target protein structure to design new drug molecules. These structures of proteins and drugs, along with many others, can be explored at RCSB PDB. </p> <div> <br/> <div class='row'> <div class='col-md-6 col-sm-12'> <a href="https://cdn.rcsb.org/pdb101/learn/resources/posters/how-do-drugs-work-poster.png" data-toggle="lightbox"> <img src="https://cdn.rcsb.org/pdb101/learn/resources/posters/how-do-drugs-work-poster.png" class="img-responsive border"> </a> <br /> </div> </div> </div> <div> <p>Download poster (26 x 38”) in high (<a href="https://cdn.rcsb.org/pdb101/learn/resources/posters/how-do-drugs-work-poster-high-res.pdf" target="_blank">PDF</a>, 11MB) or low resolution (<a href="https://cdn.rcsb.org/pdb101/learn/resources/posters/how-do-drugs-work-poster-low-res.pdf" target="_blank">PDF</a>, 1MB)</p> </div> <br/> <h4>Related Resources</h4> <div class="row"> <div class="col-xs-4 text-center"> <a href="/learn/flyers-posters-and-other-resources/flyer/how-do-drugs-work"><img class="center-block border " src="https://cdn.rcsb.org/pdb101/learn/images/tn/how-do-drugs-work-poster.png"></a> <br /> <a href="/learn/flyers-posters-and-other-resources/flyer/how-do-drugs-work"> Flyer (PDF)</a> </div> </div></div> </div> </div> </div> <div id="footer_main" class="hidden-print"> <div class="container"> <div class="row"> <div class="col-sm-12 col-md-6"> <p><strong>About PDB-101</strong></p> <p>Researchers around the globe make 3D structures freely available from the Protein Data Bank (PDB) archive. 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Education Materials provide lessons and activities for teaching and learning.</p> <p>PDB-101 is developed by the <a href="https://rcsb.org" target="_blank">RCSB PDB</a>.</p> </div> <div class="col-sm-12 col-md-6 text-center"> <p>RCSB PDB (<a href="http://nar.oxfordjournals.org/content/28/1/235.abstract" target="blank">citation</a>) is hosted by</p> <p><img src="https://cdn.rcsb.org/rcsb-pdb//v2/common/images/rad-sm.png" alt="Rutgers RAD logo.png" usemap="#rutgers-map" height="34" style="padding:0px 10px; border-right: 1px solid #666;"><img src="//cdn.rcsb.org/pdb101/common/images/Logo_UCSD-SDSC.png" alt="Logo_UCSD.png" usemap="#UCSD-SDSC-map" height="26" style="padding: 0px 10px; border-right: 1px solid #666;"><img src="//cdn.rcsb.org/pdb101/common/images/Logo_UCSF.png" alt="Logo_UCSF.png" usemap="#UCSF-map" height="26" style="padding-left: 10px;"><map name="rutgers-map"> <area shape="rect" coords="0,0,115,26" href="https://radcollaboratory.rutgers.edu/" alt="Rutgers-RAD" target="_blank"></map><map name="UCSD-SDSC-map"> <area shape="rect" coords="0,0,150,26" href="http://ucsd.edu/" alt="UCSD" target="_blank"> <area shape="rect" coords="151,0,255,26" href="http://www.sdsc.edu/" alt="SDSC" target="_blank"></map><map name="UCSF-map"> <area shape="rect" coords="0,0,64,26" href="http://www.ucsf.edu/" alt="UCSF" target="_blank"></map></p><br> <p>RCSB PDB is a member of </p> <p><span id='pdbmembers_footer'><a href='http://www.wwpdb.org/' target='_blank'><img src='//cdn.rcsb.org/pdb101/common/images/Logo_wwpdb.png' width='70'></a><span class='pipe'></span><a href='http://www.emdatabank.org/' target='_blank'><img src='https://cdn.rcsb.org/pdb101/common/images/EMDataResourcelogo.png' width='100'></a></p> </div> </div> </div> </div> <div id="footer_grant" class="hidden-print"> <div class="container"> <div class="row"> <p>RCSB PDB Core Operations are funded by the <a href="http://www.nsf.gov/" target="_blank">U.S. National Science Foundation</a> (DBI-2321666), the <a href="http://science.energy.gov/" target="_blank">US Department of Energy</a> (DE-SC0019749), and the <a href="http://www.cancer.gov/" target="_blank">National Cancer Institute</a>, <a href="http://www.niaid.nih.gov/" target="_blank">National Institute of Allergy and Infectious Diseases</a>, and <a href="http://www.nigms.nih.gov/" target="_blank">National Institute of General Medical Sciences</a> of the <a href="http://www.nih.gov/" target="_blank">National Institutes of Health</a> under grant R01GM157729.</p> </div> </div> </div> <div id="jira-fdbck"></div><script> //Google Analytics tracking code {/* (function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){ (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o), m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m) })(window,document,'script','//www.google-analytics.com/analytics.js','ga'); ga('create', 'UA-71059016-1', 'auto'); ga('send', 'pageview'); */} </script> </div> </body> </html>

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PDB-101: Learn: Flyers, Posters, & Calendars: Posters: How Do Drugs Work?